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Kam W. Leong, Ph.D. - Publications

Affiliations: 
1987-2006 Biomedical engineering Johns Hopkins University, Baltimore, MD 
 2007-2014 Biomedical engineering Duke University, Durham, NC 
 2014- Biomedical engineering Columbia University, New York, NY 
Area:
Biomaterials, Controlled Drug and Gene Delivery, Tissue Engineering
Website:
https://www.engineering.columbia.edu/faculty/kam-leong
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306 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tavakol DN, Nash TR, Kim Y, Graney PL, Liberman M, Fleischer S, Lock RI, O'Donnell A, Andrews L, Ning D, Yeager K, Harken A, Deoli N, Amundson SA, Garty G, ... Leong KW, et al. Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2401415. PMID 38965824 DOI: 10.1002/advs.202401415  0.376
2024 Xu C, Alameri A, Leong W, Johnson E, Chen Z, Xu B, Leong KW. Multiscale engineering of brain organoids for disease modeling. Advanced Drug Delivery Reviews. 115344. PMID 38810702 DOI: 10.1016/j.addr.2024.115344  0.558
2024 Zhu Y, Cai SS, Ma J, Cheng L, Wei C, Aggarwal A, Toh WH, Shin C, Shen R, Kong J, Mao SA, Lao YH, Leong KW, Mao HQ. Optimization of lipid nanoparticles for gene editing of the liver via intraduodenal delivery. Biomaterials. 308: 122559. PMID 38583366 DOI: 10.1016/j.biomaterials.2024.122559  0.462
2024 He S, Zhu Y, Chauhan S, Tavakol DN, Lee JH, Berris RB, Xu C, Lee JH, Lee C, Cai S, McElroy S, Vunjak-Novakovic G, Tomer R, Azizi E, Xu B, ... ... Leong KW, et al. Human vascular organoids with a mosaic mutation recapitulate Proteus syndrome. Biorxiv : the Preprint Server For Biology. PMID 38328122 DOI: 10.1101/2024.01.26.577324  0.405
2023 Tavakol DN, Nash TR, Kim Y, He S, Fleischer S, Graney PL, Brown JA, Liberman M, Tamargo M, Harken A, Ferrando AA, Amundson S, Garty G, Azizi E, Leong KW, et al. Modeling and countering the effects of cosmic radiation using bioengineered human tissues. Biomaterials. 301: 122267. PMID 37633022 DOI: 10.1016/j.biomaterials.2023.122267  0.389
2022 Cho S, Discher DE, Leong KW, Vunjak-Novakovic G, Wu JC. Challenges and opportunities for the next generation of cardiovascular tissue engineering. Nature Methods. 19: 1064-1071. PMID 36064773 DOI: 10.1038/s41592-022-01591-3  0.409
2022 Yang L, Hung LY, Zhu Y, Ding S, Margolis KG, Leong KW. Material Engineering in Gut Microbiome and Human Health. Research (Washington, D.C.). 2022: 9804014. PMID 35958108 DOI: 10.34133/2022/9804014  0.639
2021 Hu H, Yang C, Li M, Shao D, Mao HQ, Leong KW. Flash Technology-Based Self-Assembly in Nanoformulation: From Fabrication to Biomedical Applications. Materials Today (Kidlington, England). 42: 99-116. PMID 34421329 DOI: 10.1016/j.mattod.2020.08.019  0.423
2021 Mattiassi S, Rizwan M, Grigsby CL, Zaw AM, Leong KW, Yim EKF. Enhanced efficiency of nonviral direct neuronal reprogramming on topographical patterns. Biomaterials Science. PMID 34128504 DOI: 10.1039/d1bm00400j  0.718
2021 Lee JH, Chen Z, He S, Zhou J, Tsai A, Truskey G, Leong KW. Emulating Early Atherosclerosis in a Vascular Microphysiological System Using Branched Tissue-Engineered Blood Vessels. Advanced Biology. 5: e2000428. PMID 33852179 DOI: 10.1002/adbi.202000428  0.56
2021 Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, ... ... Leong KW, et al. The NIH Somatic Cell Genome Editing program. Nature. 592: 195-204. PMID 33828315 DOI: 10.1038/s41586-021-03191-1  0.512
2021 Chen Z, Ma N, Sun X, Li Q, Zeng Y, Chen F, Sun S, Xu J, Zhang J, Ye H, Ge J, Zhang Z, Cui X, Leong K, Chen Y, et al. Automated evaluation of tumor spheroid behavior in 3D culture using deep learning-based recognition. Biomaterials. 272: 120770. PMID 33798957 DOI: 10.1016/j.biomaterials.2021.120770  0.541
2020 Tao Y, Chan HF, Shi B, Li M, Leong KW. Light: A Magical Tool for Controlled Drug Delivery. Advanced Functional Materials. 30. PMID 34483808 DOI: 10.1002/adfm.202005029  0.63
2020 Huang D, Gibeley SB, Xu C, Xiao Y, Celik O, Ginsberg HN, Leong KW. Engineering liver microtissues for disease modeling and regenerative medicine. Advanced Functional Materials. 30. PMID 33390875 DOI: 10.1002/Adfm.201909553  0.303
2020 Deng S, Li X, Liu S, Chen J, Li M, Chew SY, Leong KW, Cheng D. Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects. Science Advances. 6: eabb4005. PMID 32832641 DOI: 10.1126/Sciadv.Abb4005  0.351
2020 Kim HS, Mandakhbayar N, Kim HW, Leong KW, Yoo HS. Protein-reactive nanofibrils decorated with cartilage-derived decellularized extracellular matrix for osteochondral defects. Biomaterials. 120214. PMID 32736808 DOI: 10.1016/J.Biomaterials.2020.120214  0.307
2020 Dawulieti J, Sun M, Zhao Y, Shao D, Yan H, Lao YH, Hu H, Cui L, Lv X, Liu F, Chi CW, Zhang Y, Li M, Zhang M, Tian H, ... ... Leong KW, et al. Treatment of severe sepsis with nanoparticulate cell-free DNA scavengers. Science Advances. 6: eaay7148. PMID 32523983 DOI: 10.1126/Sciadv.Aay7148  0.332
2020 Sun L, Le Z, He S, Liu J, Liu L, Leong KW, Mao HQ, Liu Z, Chen Y. Flash Fabrication of Orally Targeted Nanocomplexes for Improved Transport of Salmon Calcitonin across the Intestine. Molecular Pharmaceutics. PMID 32011888 DOI: 10.1021/Acs.Molpharmaceut.9B00827  0.496
2020 Tao Y, Chan HF, Shi B, Li M, Leong KW. Light: A Magical Tool for Controlled Drug Delivery Advanced Functional Materials. 30: 2005029. DOI: 10.1002/Adfm.202005029  0.66
2019 He Z, Nie T, Hu Y, Zhou Y, Zhu J, Liu Z, Liu L, Leong KW, Chen Y, Mao HQ. A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and reduce cardiovascular complications in a mouse model of type II diabetes. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 31838207 DOI: 10.1016/J.Jconrel.2019.12.014  0.528
2019 Chen R, Li L, Feng L, Luo Y, Xu M, Leong KW, Yao R. Biomaterial-assisted scalable cell production for cell therapy. Biomaterials. 119627. PMID 31767445 DOI: 10.1016/J.Biomaterials.2019.119627  0.307
2019 Yan H, Shao D, Lao YH, Li M, Hu H, Leong KW. Engineering Cell Membrane-Based Nanotherapeutics to Target Inflammation. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 6: 1900605. PMID 31406672 DOI: 10.1002/Advs.201900605  0.314
2019 Nie T, He Z, Zhou Y, Zhu J, Chen K, Liu L, Leong KW, Mao HQ, Chen Y. A Surface Coating Approach to Overcome Mucosal Entrapment of DNA Nanoparticles for Oral Gene Delivery of Glucagon-like Peptide 1. Acs Applied Materials & Interfaces. PMID 31348859 DOI: 10.1021/Acsami.9B10294  0.547
2019 Chin JS, Chooi WH, Wang H, Ong W, Leong KW, Chew SY. Scaffold-mediated non-viral delivery platform for CRISPR/Cas9-based genome editing. Acta Biomaterialia. PMID 30978509 DOI: 10.1016/J.Actbio.2019.04.020  0.354
2019 He Z, Hu Y, Gui Z, Zhou Y, Nie T, Zhu J, Liu Z, Chen K, Liu L, Leong KW, Cao P, Chen Y, Mao HQ. Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse model of type II diabetes. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30894322 DOI: 10.1016/J.Jconrel.2019.03.014  0.456
2019 Suryaprakash S, Lao YH, Cho HY, Li M, Ji HY, Shao D, Hu H, Quek CH, Huang D, Mintz R, Bagó JR, Hingtgen S, Lee KB, Leong KW. Engineered MSC/Nanomedicine Spheroid as an Active Drug Delivery Platform for Combinational Glioblastoma Therapy. Nano Letters. PMID 30773888 DOI: 10.1021/Acs.Nanolett.8B04697  0.519
2019 Peng B, Liang H, Li Y, Dong C, Shen J, Mao HQ, Leong KW, Chen Y, Liu L. Tuned Cationic Dendronized Polymer as a Molecular Scavenger for Rheumatoid Arthritis Treatment. Angewandte Chemie (International Ed. in English). PMID 30724436 DOI: 10.1002/Anie.201813362  0.509
2019 Tong S, Moyo B, Lee CM, Leong K, Bao G. Engineered materials for in vivo delivery of genome-editing machinery Nature Reviews Materials. 4: 726-737. DOI: 10.1038/S41578-019-0145-9  0.316
2018 Ye K, Kaplan DL, Bao G, Bettinger C, Forgacs G, Dong C, Khademhosseini A, Ke Y, Leong K, Sambanis A, Sun W, Yin P. Advanced Cell and Tissue Biomanufacturing. Acs Biomaterials Science & Engineering. 4: 2292-2307. PMID 33435095 DOI: 10.1021/acsbiomaterials.8b00650  0.598
2018 Sun L, Liu Z, Tian H, Le Z, Liu L, Leong KW, Mao HQ, Chen Y. Scalable Manufacturing of Enteric Encapsulation Systems for Site-Specific Oral Insulin Delivery. Biomacromolecules. PMID 30537806 DOI: 10.1021/Acs.Biomac.8B01530  0.496
2018 Le Z, Chen Y, Han H, Tian H, Zhao P, Yang C, He Z, Liu L, Leong KW, Mao HQ, Liu Z, Chen Y. Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy. Acs Applied Materials & Interfaces. PMID 30444601 DOI: 10.1021/Acsami.8B18979  0.507
2018 Zeng Z, Dong C, Zhao P, Liu Z, Liu L, Mao HQ, Leong KW, Gao X, Chen Y. Scalable Production of Therapeutic Protein Nanoparticles Using Flash Nanoprecipitation. Advanced Healthcare Materials. e1801010. PMID 30338666 DOI: 10.1002/Adhm.201801010  0.513
2018 Liang H, Peng B, Dong C, Liu L, Mao J, Wei S, Wang X, Xu H, Shen J, Mao HQ, Gao X, Leong KW, Chen Y. Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation. Nature Communications. 9: 4291. PMID 30327464 DOI: 10.1038/S41467-018-06603-5  0.507
2018 He Z, Hu Y, Nie T, Tang H, Zhu J, Chen K, Liu L, Leong KW, Chen Y, Mao HQ. Size-Controlled Lipid Nanoparticle Production Using Turbulent Mixing to Enhance Oral DNA Delivery. Acta Biomaterialia. PMID 30267888 DOI: 10.1016/J.Actbio.2018.09.047  0.539
2018 Lin PY, Chiu YL, Huang JH, Chuang EY, Mi FL, Lin KJ, Juang JH, Sung HW, Leong KW. Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 5: 1701079. PMID 30128227 DOI: 10.1002/Advs.201701079  0.313
2018 Lao YH, Li M, Gao MA, Shao D, Chi CW, Huang D, Chakraborty S, Ho TC, Jiang W, Wang HX, Wang S, Leong KW. HPV Oncogene Manipulation Using Nonvirally Delivered CRISPR/Cas9 or Argonaute. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 5: 1700540. PMID 30027026 DOI: 10.1002/Advs.201700540  0.514
2018 Tian H, He Z, Sun C, Yang C, Zhao P, Liu L, Leong KW, Mao HQ, Liu Z, Chen Y. Uniform Core-Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin. Advanced Healthcare Materials. e1800285. PMID 29984479 DOI: 10.1002/Adhm.201800285  0.514
2018 Chan HF, Zhao R, Parada GA, Meng H, Leong KW, Griffith LG, Zhao X. Folding artificial mucosa with cell-laden hydrogels guided by mechanics models. Proceedings of the National Academy of Sciences of the United States of America. PMID 29967135 DOI: 10.1073/Pnas.1802361115  0.759
2018 Chen Z, Tang M, Huang D, Jiang W, Li M, Ji H, Park J, Xu B, Atchison LJ, Truskey GA, Leong KW. Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel. Lab On a Chip. PMID 29927449 DOI: 10.1039/C8Lc00202A  0.615
2018 Pinese C, Lin J, Milbreta U, Li M, Wang Y, Leong KW, Chew SY. Sustained delivery of siRNA/mesoporous silica nanoparticle (siRNA/MSN) complexes from nanofiber scaffolds for long-term gene silencing. Acta Biomaterialia. PMID 29890267 DOI: 10.1016/J.Actbio.2018.05.054  0.366
2018 Shao D, Li M, Wang Z, Zheng X, Lao YH, Chang Z, Zhang F, Lu M, Yue J, Hu H, Yan H, Chen L, Dong WF, Leong KW. Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery. Advanced Materials (Deerfield Beach, Fla.). e1801198. PMID 29808576 DOI: 10.1002/Adma.201801198  0.37
2018 Qiao D, Liu L, Chen Y, Xue C, Gao Q, Mao HQ, Leong KW, Chen Y. Potency of A Scalable Nanoparticulate Subunit Vaccine. Nano Letters. PMID 29694053 DOI: 10.1021/Acs.Nanolett.8B00478  0.496
2018 Wang HX, Song Z, Lao YH, Xu X, Gong J, Cheng D, Chakraborty S, Park JS, Li M, Huang D, Yin L, Cheng J, Leong KW. Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide. Proceedings of the National Academy of Sciences of the United States of America. PMID 29686087 DOI: 10.1073/Pnas.1712963115  0.54
2018 He Z, Liu Z, Tian H, Hu Y, Liu L, Leong KW, Mao HQ, Chen Y. Scalable production of core-shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral delivery of insulin. Nanoscale. PMID 29384554 DOI: 10.1039/C7Nr08047F  0.523
2018 Ye K, Kaplan DL, Bao G, Bettinger C, Forgacs G, Dong C, Khademhosseini A, Ke Y, Leong K, Sambanis A, Sun W, Yin P. Advanced Cell and Tissue Biomanufacturing Acs Biomaterials Science & Engineering. 4: 2292-2307. DOI: 10.1021/Acsbiomaterials.8B00650  0.635
2018 Gong J, Tang D, Leong K. CRISPR/dCas9-mediated cell differentiation Current Opinion in Biomedical Engineering. 7: 9-15. DOI: 10.1016/J.Cobme.2018.08.005  0.332
2017 He L, Huang Y, Chang Y, You Y, Hu H, Leong KW, Chen T. A highly selective dual-therapeutic nanosystem for simultaneous anticancer and antiangiogenesis therapy. Journal of Materials Chemistry. B. 5: 8228-8237. PMID 32264466 DOI: 10.1039/C7Tb02163A  0.324
2017 Kim H, Son YJ, Mao W, Leong KW, Yoo HS. Atom transfer radical polymerization of multi-shelled cationic corona for the systemic delivery of siRNA. Nano Letters. PMID 29232130 DOI: 10.1021/Acs.Nanolett.7B04183  0.335
2017 Charoensook SN, Williams DJ, Chakraborty S, Leong KW, Vunjak-Novakovic G. Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 29168874 DOI: 10.1039/C7Ib00144D  0.565
2017 Charoensook SN, Williams DJ, Chakraborty S, Leong KW, Vunjak-Novakovic G. Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 29168874 DOI: 10.1039/C7Ib00144D  0.565
2017 Zhang J, Zheng Y, Xie X, Wang L, Su Z, Wang Y, Leong KW, Chen M. Cleavable Multifunctional Targeting Mixed Micelles with Sequential pH-Triggered TAT Peptide Activation for Improved Antihepatocellular Carcinoma Efficacy. Molecular Pharmaceutics. PMID 28994600 DOI: 10.1021/Acs.Molpharmaceut.7B00404  0.301
2017 Wang HX, Li M, Lee CM, Chakraborty S, Kim HW, Bao G, Leong KW. CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery. Chemical Reviews. PMID 28640612 DOI: 10.1021/Acs.Chemrev.6B00799  0.533
2017 Zhang J, Li J, Shi Z, Yang Y, Xie X, Lee SM, Wang Y, Leong KW, Chen M. pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities. Acta Biomaterialia. PMID 28455219 DOI: 10.1016/J.Actbio.2017.04.029  0.327
2017 He Z, Santos JL, Tian H, Huang H, Hu Y, Liu L, Leong KW, Chen Y, Mao HQ. Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin. Biomaterials. 130: 28-41. PMID 28359018 DOI: 10.1016/J.Biomaterials.2017.03.028  0.513
2017 Pelaz B, Alexiou C, Alvarez-Puebla RA, Alves F, Andrews AM, Ashraf S, Balogh LP, Ballerini L, Bestetti A, Brendel C, Bosi S, Carril M, Chan WC, Chen C, Chen X, ... ... Leong KW, et al. Diverse Applications of Nanomedicine. Acs Nano. PMID 28290206 DOI: 10.1021/Acsnano.6B06040  0.556
2017 Singh RK, Patel KD, Leong KW, Kim HW. Progress in Nanotheranostics Based on Mesoporous Silica Nanomaterial Platforms. Acs Applied Materials & Interfaces. PMID 28274115 DOI: 10.1021/Acsami.6B16505  0.327
2017 Li M, Jiang W, Chen Z, Suryaprakash S, Lv S, Tang Z, Chen X, Leong KW. A versatile platform for surface modification of microfluidic droplets. Lab On a Chip. PMID 28154857 DOI: 10.1039/C7Lc00079K  0.595
2017 Christoforou N, Chakraborty S, Kirkton RD, Adler AF, Addis RC, Leong KW. Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage. Scientific Reports. 7: 40285. PMID 28071742 DOI: 10.1038/Srep40285  0.521
2017 Seo S, Chen M, Wang H, Kang MS, Leong KW, Kim H. Extra- and intra-cellular fate of nanocarriers under dynamic interactions with biology Nano Today. 14: 84-99. DOI: 10.1016/J.Nantod.2017.04.011  0.313
2017 Suryaprakash S, Li M, Lao Y, Wang H, Leong KW. Graphene oxide cellular patches for mesenchymal stem cell-based cancer therapy Carbon. 129: 863-868. DOI: 10.1016/J.Carbon.2017.12.031  0.301
2016 Lu M, Ozcelik A, Grigsby CL, Zhao Y, Guo F, Leong KW, Huang TJ. Microfluidic Hydrodynamic Focusing for Synthesis of Nanomaterials. Nano Today. 11: 778-792. PMID 30337950 DOI: 10.1016/J.Nantod.2016.10.006  0.734
2016 Wang K, Leong KW, Yang Y. Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior. Journal of Visualized Experiments : Jove. PMID 28060299 DOI: 10.3791/54840  0.303
2016 Lee J, Jackman JG, Kwun J, Manook M, Moreno A, Elster EA, Kirk AD, Leong KW, Sullenger BA. Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis. Biomaterials. 120: 94-102. PMID 28049065 DOI: 10.1016/J.Biomaterials.2016.12.024  0.305
2016 Jiang W, Li M, Chen Z, Leong KW. Cell-laden microfluidic microgels for tissue regeneration. Lab On a Chip. PMID 27797383 DOI: 10.1039/C6Lc01193D  0.647
2016 Jackman JG, Juwarker H, Poveromo LP, Levinson H, Leong KW, Sullenger BA. Polycationic Nanofibers for Nucleic Acid Scavenging. Biomacromolecules. PMID 27741396 DOI: 10.1021/Acs.Biomac.6B01236  0.788
2016 Black JB, Adler AF, Wang HG, D'Ippolito AM, Hutchinson HA, Reddy TE, Pitt GS, Leong KW, Gersbach CA. Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. Cell Stem Cell. PMID 27524438 DOI: 10.1016/J.Stem.2016.07.001  0.304
2016 Zhao X, Yang K, Zhao R, Ji T, Wang X, Yang X, Zhang Y, Cheng K, Liu S, Hao J, Ren H, Leong KW, Nie G. Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy. Biomaterials. 102: 187-197. PMID 27343466 DOI: 10.1016/J.Biomaterials.2016.06.032  0.319
2016 Wang S, Xu Y, Chan HF, Kim HW, Wang Y, Leong KW, Chen M. phicaNanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 27091696 DOI: 10.1016/J.Jconrel.2016.04.018  0.634
2016 Chan HF, Ma S, Leong KW. Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies? Regenerative Biomaterials. 3: 87-98. PMID 27047674 DOI: 10.1093/Rb/Rbw009  0.667
2016 Peters EB, Christoforou N, Leong KW, Truskey GA, West JL. Poly(ethylene glycol) Hydrogel Scaffolds Containing Cell-Adhesive and Protease-Sensitive Peptides Support Microvessel Formation by Endothelial Progenitor Cells. Cellular and Molecular Bioengineering. 9: 38-54. PMID 27042236 DOI: 10.1007/S12195-015-0423-6  0.355
2016 Chan HF, Zhang Y, Leong KW. Efficient One-Step Production of Microencapsulated Hepatocyte Spheroids with Enhanced Functions. Small (Weinheim An Der Bergstrasse, Germany). PMID 27038291 DOI: 10.1002/Smll.201502932  0.665
2016 Ji H, Atchison L, Chen Z, Chakraborty S, Jung Y, Truskey GA, Christoforou N, Leong KW. Transdifferentiation of human endothelial progenitors into smooth muscle cells. Biomaterials. 85: 180-194. PMID 26874281 DOI: 10.1016/J.Biomaterials.2016.01.066  0.69
2016 Suryaprakash S, Chan HF, Rodriguez J, Hingtgen S, Leong KW. 242. Genetically Engineered Mesenchymal Stem Cell Spheroids for Brain Tumor Therapy Molecular Therapy. 24: S95. DOI: 10.1016/S1525-0016(16)33051-9  0.661
2016 Perez RA, Choi SJ, Han CM, Kim JJ, Shim H, Leong KW, Kim HW. Biomaterials control of pluripotent stem cell fate for regenerative therapy Progress in Materials Science. 82: 234-293. DOI: 10.1016/J.Pmatsci.2016.05.003  0.33
2016 Wang HX, Zuo ZQ, Du JZ, Wang YC, Sun R, Cao ZT, Ye XD, Wang JL, Leong KW, Wang J. Surface charge critically affects tumor penetration and therapeutic efficacy of cancer nanomedicines Nano Today. DOI: 10.1016/J.Nantod.2016.04.008  0.309
2015 Phua KK, Staats HF, Nair SK, Leong KW. Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity. Journal of Controlled Release : Official Journal of the Controlled Release Society. 213: e66-7. PMID 27005208 DOI: 10.1016/J.Jconrel.2015.05.110  0.658
2015 Zhang Y, Phua K, Chan HF, Sullenger B, Leong KW. Immobilization of nucleic acid binding polymers as anti-inflammatory agent in autoimmunity. Journal of Controlled Release : Official Journal of the Controlled Release Society. 213: e136. PMID 27005091 DOI: 10.1016/J.Jconrel.2015.05.230  0.761
2015 Gallego-Perez D, Otero JJ, Czeisler C, Ma J, Ortiz C, Gygli P, Catacutan FP, Gokozan HN, Cowgill A, Sherwood T, Ghatak S, Malkoc V, Zhao X, Liao WC, Gnyawali S, ... ... Leong K, et al. Deterministic Transfection Drives Efficient Nonviral Reprogramming and Uncovers Reprogramming Barriers. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 26711960 DOI: 10.1016/J.Nano.2015.11.015  0.317
2015 Lorden ER, Miller KJ, Ibrahim MM, Bashirov L, Hammett E, Chakraborty S, Quiles-Torres C, Selim MA, Leong KW, Levinson H. Biostable electrospun microfibrous scaffolds mitigate hypertrophic scar contraction in an immune-competent murine model. Acta Biomaterialia. PMID 26708709 DOI: 10.1016/J.Actbio.2015.12.025  0.493
2015 Jung Y, Ji H, Chen Z, Fai Chan H, Atchison L, Klitzman B, Truskey G, Leong KW. Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. Scientific Reports. 5: 15116. PMID 26456074 DOI: 10.1038/Srep15116  0.633
2015 Baek S, Singh RK, Khanal D, Patel KD, Lee EJ, Leong KW, Chrzanowski W, Kim HW. Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles. Nanoscale. 7: 14191-216. PMID 26260245 DOI: 10.1039/C5Nr02730F  0.359
2015 Hong S, Sycks D, Chan HF, Lin S, Lopez GP, Guilak F, Leong KW, Zhao X. 3D Printing: 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. Advanced Materials (Deerfield Beach, Fla.). 27: 4034. PMID 26172844 DOI: 10.1002/Adma.201570182  0.695
2015 Hong S, Sycks D, Chan HF, Lin S, Lopez GP, Guilak F, Leong KW, Zhao X. 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. Advanced Materials (Deerfield Beach, Fla.). 27: 4035-40. PMID 26033288 DOI: 10.1002/Adma.201501099  0.707
2015 Juul S, Obliosca JM, Liu C, Liu YL, Chen YA, Imphean DM, Knudsen BR, Ho YP, Leong KW, Yeh HC. NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection. Nanoscale. 7: 8332-7. PMID 25901841 DOI: 10.1039/C5Nr01705J  0.614
2015 Lorden ER, Levinson HM, Leong KW. Integration of drug, protein, and gene delivery systems with regenerative medicine. Drug Delivery and Translational Research. 5: 168-86. PMID 25787742 DOI: 10.1007/S13346-013-0165-8  0.361
2015 Park JS, Suryaprakash S, Lao YH, Leong KW. Engineering mesenchymal stem cells for regenerative medicine and drug delivery. Methods (San Diego, Calif.). PMID 25770356 DOI: 10.1016/J.Ymeth.2015.03.002  0.344
2015 Lao YH, Phua KK, Leong KW. Aptamer nanomedicine for cancer therapeutics: barriers and potential for translation. Acs Nano. 9: 2235-54. PMID 25731717 DOI: 10.1021/Nn507494P  0.682
2015 Diekman BO, Thakore PI, O'Connor SK, Willard VP, Brunger JM, Christoforou N, Leong KW, Gersbach CA, Guilak F. Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. Tissue Engineering. Part A. 21: 1261-74. PMID 25517798 DOI: 10.1089/Ten.Tea.2014.0240  0.33
2015 Jackman JG, Juwarker H, Bashirov L, Leong K, Levinson H, Sullenger B. 272. Nucleic Acid Scavenging Nanofibers as Anti-Inflammatory Meshes Molecular Therapy. 23: S108-S109. DOI: 10.1016/S1525-0016(16)33881-3  0.792
2015 Black J, Adler A, Hutchinson H, Wang H, Pitt G, Leong K, Gersbach C. 59. Multiplex Gene Activation by CRISPR/Cas9-Based Transcription Factors for the Direct Conversion of Fibroblasts to a Neuronal Phenotype Molecular Therapy. 23: S26. DOI: 10.1016/S1525-0016(16)33664-4  0.329
2014 Chen Z, Atchison L, Ji H, Leong KW. Nanograting structure promotes lamellipodia-based cell collective migration and wound healing. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2014: 2916-9. PMID 25570601 DOI: 10.1109/EMBC.2014.6944233  0.582
2014 Chakraborty S, Ji H, Chen J, Gersbach CA, Leong KW. Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis. Scientific Reports. 4: 7403. PMID 25492703 DOI: 10.1038/Srep07403  0.509
2014 Xing Q, Vogt C, Leong KW, Zhao F. Highly Aligned Nanofibrous Scaffold Derived from Decellularized Human Fibroblasts. Advanced Functional Materials. 24: 3027-3035. PMID 25484849 DOI: 10.1002/Adfm.201303460  0.342
2014 Chakraborty S, Ji H, Kabadi AM, Gersbach CA, Christoforou N, Leong KW. A CRISPR/Cas9-based system for reprogramming cell lineage specification. Stem Cell Reports. 3: 940-7. PMID 25448066 DOI: 10.1016/J.Stemcr.2014.09.013  0.515
2014 Lu M, Yang S, Ho YP, Grigsby CL, Leong KW, Huang TJ. Shape-controlled synthesis of hybrid nanomaterials via three-dimensional hydrodynamic focusing. Acs Nano. 8: 10026-34. PMID 25268035 DOI: 10.1021/Nn502549V  0.774
2014 Willard VP, Diekman BO, Sanchez-Adams J, Christoforou N, Leong KW, Guilak F. Use of cartilage derived from murine induced pluripotent stem cells for osteoarthritis drug screening. Arthritis & Rheumatology (Hoboken, N.J.). 66: 3062-72. PMID 25047145 DOI: 10.1002/Art.38780  0.301
2014 Williford JM, Wu J, Ren Y, Archang MM, Leong KW, Mao HQ. Recent advances in nanoparticle-mediated siRNA delivery. Annual Review of Biomedical Engineering. 16: 347-70. PMID 24905873 DOI: 10.1146/Annurev-Bioeng-071813-105119  0.554
2014 Phua KK, Nair SK, Leong KW. Messenger RNA (mRNA) nanoparticle tumour vaccination. Nanoscale. 6: 7715-29. PMID 24904987 DOI: 10.1039/C4Nr01346H  0.673
2014 Phua KK, Staats HF, Leong KW, Nair SK. Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity. Scientific Reports. 4: 5128. PMID 24894817 DOI: 10.1038/Srep05128  0.675
2014 Chiu YL, Chan HF, Phua KK, Zhang Y, Juul S, Knudsen BR, Ho YP, Leong KW. Synthesis of fluorosurfactants for emulsion-based biological applications. Acs Nano. 8: 3913-20. PMID 24646088 DOI: 10.1021/Nn500810N  0.793
2014 Lu M, Ho YP, Grigsby CL, Nawaz AA, Leong KW, Huang TJ. Three-dimensional hydrodynamic focusing method for polyplex synthesis. Acs Nano. 8: 332-9. PMID 24341632 DOI: 10.1021/Nn404193E  0.793
2014 Phua KK, Boczkowski D, Dannull J, Pruitt S, Leong KW, Nair SK. Whole blood cells loaded with messenger RNA as an anti-tumor vaccine. Advanced Healthcare Materials. 3: 837-42. PMID 24339387 DOI: 10.1002/Adhm.201300512  0.665
2014 Cao C, Chan HF, Zang J, Leong KW, Zhao X. Harnessing localized ridges for high-aspect-ratio hierarchical patterns with dynamic tunability and multifunctionality. Advanced Materials (Deerfield Beach, Fla.). 26: 1763-70. PMID 24339233 DOI: 10.1002/Adma.201304589  0.698
2014 Hong S, Jung Y, Yen R, Chan HF, Leong KW, Truskey GA, Zhao X. Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems. Lab On a Chip. 14: 514-21. PMID 24310854 DOI: 10.1039/C3Lc51076J  0.682
2014 Boukany PE, Wu Y, Zhao X, Kwak KJ, Glazer PJ, Leong K, Lee LJ. Nonendocytic delivery of lipoplex nanoparticles into living cells using nanochannel electroporation Advanced Healthcare Materials. 3: 682-689. PMID 23996973 DOI: 10.1002/Adhm.201300213  0.393
2014 Cao C, Chan HF, Zang J, Leong KW, Zhao X. Hierarchical Patterns: Harnessing Localized Ridges for High-Aspect-Ratio Hierarchical Patterns with Dynamic Tunability and Multifunctionality (Adv. Mater. 11/2014) Advanced Materials. 26: 1633-1633. DOI: 10.1002/Adma.201470068  0.669
2014 Boukany PE, Wu Y, Zhao X, Kwak KJ, Glazer PJ, Leong K, Lee LJ. Gene Delivery: Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation (Adv. Healthcare Mater. 5/2014) Advanced Healthcare Materials. 3: 622-622. DOI: 10.1002/Adhm.201470023  0.343
2013 Godsey ME, Suryaprakash S, Leong KW. Materials innovation for co-delivery of diverse therapeutic cargos. Rsc Advances. 3: 24794-24811. PMID 24818000 DOI: 10.1039/C3Ra43094D  0.347
2013 Truskey GA, Achneck HE, Bursac N, Chan H, Cheng CS, Fernandez C, Hong S, Jung Y, Koves T, Kraus WE, Leong K, Madden L, Reichert WM, Zhao X. Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. Stem Cell Research & Therapy. 4: S10. PMID 24565225 DOI: 10.1186/Scrt371  0.698
2013 Chan HF, Zhang Y, Ho YP, Chiu YL, Jung Y, Leong KW. Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment. Scientific Reports. 3: 3462. PMID 24322507 DOI: 10.1038/Srep03462  0.772
2013 Grigsby CL, Ho YP, Lin C, Engbersen JF, Leong KW. Microfluidic preparation of polymer-nucleic acid nanocomplexes improves nonviral gene transfer. Scientific Reports. 3: 3155. PMID 24193511 DOI: 10.1038/Srep03155  0.806
2013 Juul S, Iacovelli F, Falconi M, Kragh SL, Christensen B, Frøhlich R, Franch O, Kristoffersen EL, Stougaard M, Leong KW, Ho YP, Sørensen ES, Birkedal V, Desideri A, Knudsen BR. Temperature-controlled encapsulation and release of an active enzyme in the cavity of a self-assembled DNA nanocage. Acs Nano. 7: 9724-34. PMID 24168393 DOI: 10.1021/Nn4030543  0.625
2013 Son YJ, Kim H, Leong KW, Yoo HS. Multifunctional nanorods serving as nanobridges to modulate T cell-mediated immunity. Acs Nano. 7: 9771-9. PMID 24088178 DOI: 10.1021/Nn403275P  0.317
2013 Chen J, Lee EJ, Jing L, Christoforou N, Leong KW, Setton LA. Differentiation of mouse induced pluripotent stem cells (iPSCs) into nucleus pulposus-like cells in vitro. Plos One. 8: e75548. PMID 24086564 DOI: 10.1371/Journal.Pone.0075548  0.313
2013 Christoforou N, Liau B, Chakraborty S, Chellapan M, Bursac N, Leong KW. Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. Plos One. 8: e65963. PMID 23785459 DOI: 10.1371/Journal.Pone.0065963  0.521
2013 Chakraborty S, Christoforou N, Fattahi A, Herzog RW, Leong KW. A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells. Plos One. 8: e64342. PMID 23717601 DOI: 10.1371/Journal.Pone.0064342  0.522
2013 Christoforou N, Chellappan M, Adler AF, Kirkton RD, Wu T, Addis RC, Bursac N, Leong KW. Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. Plos One. 8: e63577. PMID 23704920 DOI: 10.1371/Journal.Pone.0063577  0.301
2013 Zhang Y, Ho YP, Chiu YL, Chan HF, Chlebina B, Schuhmann T, You L, Leong KW. A programmable microenvironment for cellular studies via microfluidics-generated double emulsions. Biomaterials. 34: 4564-72. PMID 23522800 DOI: 10.1016/J.Biomaterials.2013.03.002  0.75
2013 Leong KW, Sung HW. Nanoparticle- and biomaterials-mediated oral delivery for drug, gene, and immunotherapy. Advanced Drug Delivery Reviews. 65: 757-8. PMID 23434918 DOI: 10.1016/J.Addr.2013.02.002  0.319
2013 Gamboa JM, Leong KW. In vitro and in vivo models for the study of oral delivery of nanoparticles. Advanced Drug Delivery Reviews. 65: 800-10. PMID 23415952 DOI: 10.1016/J.Addr.2013.01.003  0.335
2013 Phua KK, Leong KW, Nair SK. Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format. Journal of Controlled Release : Official Journal of the Controlled Release Society. 166: 227-33. PMID 23306021 DOI: 10.1016/J.Jconrel.2012.12.029  0.686
2013 Zhang Y, Chan HF, Leong KW. Advanced materials and processing for drug delivery: the past and the future. Advanced Drug Delivery Reviews. 65: 104-20. PMID 23088863 DOI: 10.1016/J.Addr.2012.10.003  0.652
2013 Choy AT, Leong KW, Chan BP. Chemical modification of collagen improves glycosaminoglycan retention of their co-precipitates. Acta Biomaterialia. 9: 4661-72. PMID 23009864 DOI: 10.1016/J.Actbio.2012.09.016  0.303
2012 Adler AF, Grigsby CL, Kulangara K, Wang H, Yasuda R, Leong KW. Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells. Molecular Therapy. Nucleic Acids. 1: e32. PMID 23344148 DOI: 10.1038/Mtna.2012.25  0.734
2012 Juul S, Nielsen CJ, Labouriau R, Roy A, Tesauro C, Jensen PW, Harmsen C, Kristoffersen EL, Chiu YL, Frøhlich R, Fiorani P, Cox-Singh J, Tordrup D, Koch J, Bienvenu AL, ... ... Leong KW, et al. Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement. Acs Nano. 6: 10676-83. PMID 23121492 DOI: 10.1021/Nn3038594  0.605
2012 Diekman BO, Christoforou N, Willard VP, Sun H, Sanchez-Adams J, Leong KW, Guilak F. Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 19172-7. PMID 23115336 DOI: 10.1073/Pnas.1210422109  0.331
2012 Yang Y, Kulangara K, Lam RT, Dharmawan R, Leong KW. Effects of topographical and mechanical property alterations induced by oxygen plasma modification on stem cell behavior. Acs Nano. 6: 8591-8. PMID 22970773 DOI: 10.1021/Nn301713D  0.312
2012 Kolind K, Leong KW, Besenbacher F, Foss M. Guidance of stem cell fate on 2D patterned surfaces. Biomaterials. 33: 6626-33. PMID 22748769 DOI: 10.1016/J.Biomaterials.2012.05.070  0.304
2012 Grigsby CL, Ho YP, Leong KW. Understanding nonviral nucleic acid delivery with quantum dot-FRET nanosensors. Nanomedicine (London, England). 7: 565-77. PMID 22471720 DOI: 10.2217/Nnm.12.28  0.789
2012 Loo Y, Grigsby CL, Yamanaka YJ, Chellappan MK, Jiang X, Mao HQ, Leong KW. Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models. Journal of Controlled Release : Official Journal of the Controlled Release Society. 160: 48-56. PMID 22326811 DOI: 10.1016/J.Jconrel.2012.01.041  0.796
2012 Park S, Son YJ, Leong KW, Yoo HS. Therapeutic nanorods with metallic multi-segments: Thermally inducible encapsulation of doxorubicin for anti-cancer therapy Nano Today. 7: 76-84. DOI: 10.1016/J.Nantod.2012.02.005  0.325
2011 Li H, Labean TH, Leong KW. Nucleic acid-based nanoengineering: novel structures for biomedical applications. Interface Focus. 1: 702-24. PMID 23050076 DOI: 10.1098/Rsfs.2011.0040  0.331
2011 Juul S, Ho YP, Stougaard M, Koch J, Andersen FF, Leong KW, Knudsen BR. Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 3258-61. PMID 22255034 DOI: 10.1109/IEMBS.2011.6090885  0.584
2011 Juul S, Ho YP, Koch J, Andersen FF, Stougaard M, Leong KW, Knudsen BR. Detection of single enzymatic events in rare or single cells using microfluidics. Acs Nano. 5: 8305-10. PMID 21936557 DOI: 10.1021/Nn203012Q  0.625
2011 Liau B, Christoforou N, Leong KW, Bursac N. Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function. Biomaterials. 32: 9180-7. PMID 21906802 DOI: 10.1016/J.Biomaterials.2011.08.050  0.312
2011 Lee J, Sohn JW, Zhang Y, Leong KW, Pisetsky D, Sullenger BA. Nucleic acid-binding polymers as anti-inflammatory agents. Proceedings of the National Academy of Sciences of the United States of America. 108: 14055-60. PMID 21844380 DOI: 10.1073/Pnas.1105777108  0.307
2011 Yuan M, Leong KW, Chan BP. Three-dimensional culture of rabbit nucleus pulposus cells in collagen microspheres. The Spine Journal : Official Journal of the North American Spine Society. 11: 947-60. PMID 21843975 DOI: 10.1016/J.Spinee.2011.07.004  0.32
2011 Wu Y, Ho YP, Mao Y, Wang X, Yu B, Leong KW, Lee LJ. Uptake and intracellular fate of multifunctional nanoparticles: a comparison between lipoplexes and polyplexes via quantum dot mediated Förster resonance energy transfer. Molecular Pharmaceutics. 8: 1662-8. PMID 21740056 DOI: 10.1021/Mp100466M  0.647
2011 Le DM, Kulangara K, Adler AF, Leong KW, Ashby VS. Dynamic topographical control of mesenchymal stem cells by culture on responsive poly(ε-caprolactone) surfaces. Advanced Materials (Deerfield Beach, Fla.). 23: 3278-83. PMID 21626577 DOI: 10.1002/Adma.201100821  0.328
2011 Ho YP, Grigsby CL, Zhao F, Leong KW. Tuning physical properties of nanocomplexes through microfluidics-assisted confinement. Nano Letters. 11: 2178-82. PMID 21506589 DOI: 10.1021/Nl200862N  0.788
2011 Yang Y, Kulangara K, Sia J, Wang L, Leong KW. Engineering of a microfluidic cell culture platform embedded with nanoscale features. Lab On a Chip. 11: 1638-46. PMID 21442110 DOI: 10.1039/C0Lc00736F  0.338
2011 Adler AF, Speidel AT, Christoforou N, Kolind K, Foss M, Leong KW. High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts. Biomaterials. 32: 3611-9. PMID 21334062 DOI: 10.1016/J.Biomaterials.2011.01.040  0.354
2011 Sun TM, Du JZ, Yao YD, Mao CQ, Dou S, Huang SY, Zhang PZ, Leong KW, Song EW, Wang J. Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression. Acs Nano. 5: 1483-94. PMID 21204585 DOI: 10.1021/Nn103349H  0.345
2011 Dai H, Jiang X, Leong KW, Mao HQ. Transient depletion of kupffer cells leads to enhanced transgene expression in rat liver following retrograde intrabiliary infusion of plasmid DNA and DNA nanoparticles. Human Gene Therapy. 22: 873-8. PMID 21091274 DOI: 10.1089/Hum.2010.146  0.519
2011 Liao IC, Leong KW. Efficacy of engineered FVIII-producing skeletal muscle enhanced by growth factor-releasing co-axial electrospun fibers. Biomaterials. 32: 1669-77. PMID 21084118 DOI: 10.1016/J.Biomaterials.2010.10.049  0.58
2010 Adler AF, Leong KW. Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery. Nano Today. 5: 553-569. PMID 21383869 DOI: 10.1016/J.Nantod.2010.10.007  0.342
2010 Yang Y, Leong KW. Nanoscale surfacing for regenerative medicine. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 2: 478-95. PMID 20803682 DOI: 10.1002/Wnan.74  0.317
2010 Ho YP, Leong KW. Quantum dot-based theranostics. Nanoscale. 2: 60-8. PMID 20648364 DOI: 10.1039/B9Nr00178F  0.619
2010 Wu Y, Liao IC, Kennedy SJ, Du J, Wang J, Leong KW, Clark RL. Electrosprayed core-shell microspheres for protein delivery. Chemical Communications (Cambridge, England). 46: 4743-5. PMID 20485844 DOI: 10.1039/C0Cc00535E  0.58
2010 Jiang X, Zheng Y, Chen HH, Leong KW, Wang TH, Mao HQ. Dual-sensitive micellar nanoparticles regulate DNA unpacking and enhance gene-delivery efficiency. Advanced Materials (Deerfield Beach, Fla.). 22: 2556-60. PMID 20440698 DOI: 10.1002/Adma.200903933  0.552
2010 Phua K, Leong KW. Microscale oral delivery devices incorporating nanoparticles. Nanomedicine (London, England). 5: 161-3. PMID 20148626 DOI: 10.2217/Nnm.09.113  0.707
2010 Chen S, Jones JA, Xu Y, Low HY, Anderson JM, Leong KW. Characterization of topographical effects on macrophage behavior in a foreign body response model. Biomaterials. 31: 3479-91. PMID 20138663 DOI: 10.1016/J.Biomaterials.2010.01.074  0.33
2010 Kadiyala I, Loo Y, Roy K, Rice J, Leong KW. Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 39: 103-9. PMID 19913612 DOI: 10.1016/J.Ejps.2009.11.002  0.571
2010 Grigsby CL, Leong KW. Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery. Journal of the Royal Society, Interface / the Royal Society. 7: S67-82. PMID 19734186 DOI: 10.1098/Rsif.2009.0260  0.76
2010 Ho Y, Duan Y, Zhao F, Leong KW. Controlled Synthesis of DNA Nanocomplexes in a Microfluidic Device Biophysical Journal. 98: 193a. DOI: 10.1016/J.Bpj.2009.12.1024  0.366
2009 Chen HH, Ho YP, Jiang X, Mao HQ, Wang TH, Leong KW. Simultaneous Non-invasive Analysis of DNA Condensation and Stability by Two-step QD-FRET. Nano Today. 4: 125-134. PMID 20161048 DOI: 10.1016/J.Nantod.2009.02.008  0.705
2009 Oney S, Lam RT, Bompiani KM, Blake CM, Quick G, Heidel JD, Liu JY, Mack BC, Davis ME, Leong KW, Sullenger BA. Development of universal antidotes to control aptamer activity. Nature Medicine. 15: 1224-8. PMID 19801990 DOI: 10.1038/Nm.1990  0.311
2009 Ho YP, Chen HH, Leong KW, Wang TH. Combining QD-FRET and microfluidics to monitor DNA nanocomplex self-assembly in real-time. Journal of Visualized Experiments : Jove. PMID 19710626 DOI: 10.3791/1432  0.654
2009 Chakraborty S, Liao IC, Adler A, Leong KW. Electrohydrodynamics: A facile technique to fabricate drug delivery systems. Advanced Drug Delivery Reviews. 61: 1043-54. PMID 19651167 DOI: 10.1016/J.Addr.2009.07.013  0.675
2009 Liao IC, Chen S, Liu JB, Leong KW. Sustained viral gene delivery through core-shell fibers. Journal of Controlled Release : Official Journal of the Controlled Release Society. 139: 48-55. PMID 19539680 DOI: 10.1016/J.Jconrel.2009.06.007  0.614
2009 Ho YP, Chen HH, Leong KW, Wang TH. The convergence of quantum-dot-mediated fluorescence resonance energy transfer and microfluidics for monitoring DNA polyplex self-assembly in real time. Nanotechnology. 20: 095103. PMID 19417478 DOI: 10.1088/0957-4484/20/9/095103  0.622
2009 Yow SZ, Quek CH, Yim EK, Lim CT, Leong KW. Collagen-based fibrous scaffold for spatial organization of encapsulated and seeded human mesenchymal stem cells. Biomaterials. 30: 1133-42. PMID 19041132 DOI: 10.1016/J.Biomaterials.2008.11.003  0.348
2009 Gutsche AT, Parsons-Wingerter P, Chand D, Saltzman WM, Saltzman WM, Leong KW. N-acetylglucosamine and adenosine derivatized surfaces for cell culture: 3T3 fibroblast and chicken hepatocyte response. Biotechnology and Bioengineering. 43: 801-9. PMID 18615804 DOI: 10.1002/Bit.260430815  0.512
2009 Lou YL, Peng YS, Chen BH, Wang LF, Leong KW. Poly(ethylene imine)-g-chitosan using EX-810 as a spacer for nonviral gene delivery vectors. Journal of Biomedical Materials Research. Part A. 88: 1058-68. PMID 18404706 DOI: 10.1002/Jbm.A.31961  0.371
2009 Kulangara K, Leong KW. Substrate topography shapes cell function Soft Matter. 5: 4072-4076. DOI: 10.1039/B910132M  0.341
2009 Chen HH, Ho Y, Jiang X, Mao H, Wang T, Leong KW. Erratum to “Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET” [Nano Today 4 (2009) 125–134] Nano Today. 4: 280. DOI: 10.1016/J.Nantod.2009.04.003  0.456
2009 Ho Y, Chen HH, Leong KW, Wang T. Spatially-resolved Analysis Of DNA Nanocomplex Self-assembly Enabled By Integrating Nanophotonics And Microfluidics Biophysical Journal. 96: 313a. DOI: 10.1016/J.Bpj.2008.12.1566  0.356
2008 Liao IC, Liu JB, Bursac N, Leong KW. Effect of Electromechanical Stimulation on the Maturation of Myotubes on Aligned Electrospun Fibers. Cellular and Molecular Bioengineering. 1: 133-145. PMID 19774099 DOI: 10.1007/S12195-008-0021-Y  0.577
2008 Yamanaka YJ, Leong KW. Engineering strategies to enhance nanoparticle-mediated oral delivery. Journal of Biomaterials Science. Polymer Edition. 19: 1549-70. PMID 19017470 DOI: 10.1163/156856208786440479  0.337
2008 Bowman K, Sarkar R, Raut S, Leong KW. Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 132: 252-9. PMID 18634839 DOI: 10.1016/J.Jconrel.2008.06.019  0.339
2008 Chen HH, Ho YP, Jiang X, Mao HQ, Wang TH, Leong KW. Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum dot-FRET. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 324-32. PMID 18180773 DOI: 10.1038/Sj.Mt.6300392  0.711
2008 Chew SY, Mi R, Hoke A, Leong KW. The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation. Biomaterials. 29: 653-61. PMID 17983651 DOI: 10.1016/J.Biomaterials.2007.10.025  0.302
2008 Haider M, Cappello J, Ghandehari H, Leong KW. In vitro chondrogenesis of mesenchymal stem cells in recombinant silk-elastinlike hydrogels. Pharmaceutical Research. 25: 692-9. PMID 17404809 DOI: 10.1007/S11095-007-9282-8  0.331
2007 Chew SY, Mi R, Hoke A, Leong KW. Aligned Protein-Polymer Composite Fibers Enhance Nerve Regeneration: A Potential Tissue-Engineering Platform. Advanced Functional Materials. 17: 1288-1296. PMID 18618021 DOI: 10.1002/Adfm.200600441  0.304
2007 Dang JM, Leong KW. Myogenic Induction of Aligned Mesenchymal Stem Cell Sheets by Culture on Thermally Responsive Electrospun Nanofibers. Advanced Materials (Deerfield Beach, Fla.). 19: 2775-2779. PMID 18584057 DOI: 10.1002/Adma.200602159  0.346
2007 Bursac N, Loo Y, Leong K, Tung L. Novel anisotropic engineered cardiac tissues: studies of electrical propagation. Biochemical and Biophysical Research Communications. 361: 847-53. PMID 17689494 DOI: 10.1016/J.Bbrc.2007.07.138  0.561
2007 Chua KN, Chai C, Lee PC, Ramakrishna S, Leong KW, Mao HQ. Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor cells. Experimental Hematology. 35: 771-81. PMID 17577926 DOI: 10.1016/J.Exphem.2007.02.002  0.496
2007 Chua KN, Tang YN, Quek CH, Ramakrishna S, Leong KW, Mao HQ. A dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes. Acta Biomaterialia. 3: 643-50. PMID 17532276 DOI: 10.1016/J.Actbio.2007.03.012  0.512
2007 Yim EK, Liao IC, Leong KW. Tissue compatibility of interfacial polyelectrolyte complexation fibrous scaffold: evaluation of blood compatibility and biocompatibility. Tissue Engineering. 13: 423-33. PMID 17518574 DOI: 10.1089/Ten.2006.0113  0.609
2007 Park DJ, Choi JH, Leong KW, Kwon JW, Eun HS. Tissue-engineered bone formation with gene transfer and mesenchymal stem cells in a minimally invasive technique. Laryngoscope. 117: 1267-1271. PMID 17507830 DOI: 10.1097/Mlg.0B013E31805F680E  0.345
2007 Sharma B, Williams CG, Kim TK, Sun D, Malik A, Khan M, Leong K, Elisseeff JH. Designing zonal organization into tissue-engineered cartilage Tissue Engineering. 13: 405-414. PMID 17504064 DOI: 10.1089/Ten.2006.0068  0.33
2007 Chai C, Leong KW. Biomaterials approach to expand and direct differentiation of stem cells Molecular Therapy. 15: 467-480. PMID 17264853 DOI: 10.1038/Sj.Mt.6300084  0.319
2007 Chen B, Dang J, Tan TL, Fang N, Chen WN, Leong KW, Chan V. Dynamics of smooth muscle cell deadhesion from thermosensitive hydroxybutyl chitosan. Biomaterials. 28: 1503-14. PMID 17157377 DOI: 10.1016/J.Biomaterials.2006.11.027  0.333
2007 Zhang Y, Chai C, Jiang XS, Teoh SH, Leong KW. Fibronectin immobilized by covalent conjugation or physical adsorption shows different bioactivity on aminated-PET Materials Science and Engineering: C. 27: 213-219. DOI: 10.1016/J.Msec.2006.03.013  0.303
2006 Chew SY, Hufnagel TC, Lim CT, Leong KW. Mechanical properties of single electrospun drug-encapsulated nanofibres. Nanotechnology. 17: 3880-3891. PMID 19079553 DOI: 10.1088/0957-4484/17/15/045  0.338
2006 Bowman K, Leong KW. Chitosan nanoparticles for oral drug and gene delivery. International Journal of Nanomedicine. 1: 117-128. PMID 17722528 DOI: 10.2147/Nano.2006.1.2.117  0.352
2006 Liao IC, Chew SY, Leong KW. Aligned core-shell nanofibers delivering bioactive proteins. Nanomedicine (London, England). 1: 465-71. PMID 17716148 DOI: 10.2217/17435889.1.4.465  0.567
2006 Dai H, Jiang X, Tan GC, Chen Y, Torbenson M, Leong KW, Mao HQ. Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery. International Journal of Nanomedicine. 1: 507-22. PMID 17369870 DOI: 10.2147/Nano.2006.1.4.507  0.519
2006 Chew SY, Wen Y, Dzenis Y, Leong KW. The role of electrospinning in the emerging field of nanomedicine. Current Pharmaceutical Design. 12: 4751-70. PMID 17168776 DOI: 10.2174/138161206779026326  0.37
2006 Ho YP, Chen HH, Leong KW, Wang TH. Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET. Journal of Controlled Release : Official Journal of the Controlled Release Society. 116: 83-9. PMID 17081642 DOI: 10.1016/J.Jconrel.2006.09.005  0.651
2006 Visage CL, Yang SH, Kadakia L, Sieber AN, Kostuik JP, Leong KW. Small intestinal submucosa as a potential bioscaffold for intervertebral disc regeneration. Spine. 31: 2423-2430. PMID 17023850 DOI: 10.1097/01.Brs.0000238684.04792.Eb  0.325
2006 Yim EK, Wan AC, Le Visage C, Liao IC, Leong KW. Proliferation and differentiation of human mesenchymal stem cell encapsulated in polyelectrolyte complexation fibrous scaffold. Biomaterials. 27: 6111-22. PMID 16919722 DOI: 10.1016/J.Biomaterials.2006.07.037  0.613
2006 Visage CL, Kim SW, Tateno K, Sieber AN, Kostuik JP, Leong KW. Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis. Spine. 31: 2036-2042. PMID 16915085 DOI: 10.1097/01.Brs.0000231442.05245.87  0.334
2006 Chua KN, Chai C, Lee PC, Tang YN, Ramakrishna S, Leong KW, Mao HQ. Surface-aminated electrospun nanofibers enhance adhesion and expansion of human umbilical cord blood hematopoietic stem/progenitor cells. Biomaterials. 27: 6043-51. PMID 16854459 DOI: 10.1016/J.Biomaterials.2006.06.017  0.512
2006 Wu D, Liu Y, Jiang X, He C, Goh SH, Leong KW. Hyperbranched poly(amino ester)s with different terminal amine groups for DNA delivery. Biomacromolecules. 7: 1879-83. PMID 16768410 DOI: 10.1021/Bm0601878  0.32
2006 Dang JM, Leong KW. Natural polymers for gene delivery and tissue engineering Advanced Drug Delivery Reviews. 58: 487-499. PMID 16762443 DOI: 10.1016/J.Addr.2006.03.001  0.351
2006 Feng Q, Chai C, Jiang XS, Leong KW, Mao HQ. Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin. Journal of Biomedical Materials Research. Part A. 78: 781-91. PMID 16739181 DOI: 10.1002/Jbm.A.30829  0.521
2006 Yim EKF, Wen J, Leong KW. Enhanced extracellular matrix production and differentiation of human embryonic germ cell derivatives in biodegradable poly(ε-caprolactone-co-ethyl ethylene phosphate) scaffold Acta Biomaterialia. 2: 365-376. PMID 16709468 DOI: 10.1016/J.Actbio.2006.03.006  0.342
2006 Li J, Li X, Ni X, Wang X, Li H, Leong KW. Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and alpha-cyclodextrin for controlled drug delivery. Biomaterials. 27: 4132-40. PMID 16584769 DOI: 10.1016/J.Biomaterials.2006.03.025  0.322
2006 Lim SH, Liao IC, Leong KW. Nonviral gene delivery from nonwoven fibrous scaffolds fabricated by interfacial complexation of polyelectrolytes. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 1163-72. PMID 16497560 DOI: 10.1016/J.Ymthe.2005.12.016  0.726
2006 Wong K, Sun G, Zhang X, Dai H, Liu Y, He C, Leong KW. PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo. Bioconjugate Chemistry. 17: 152-8. PMID 16417264 DOI: 10.1021/Bc0501597  0.31
2006 Jiang X, Dai H, Leong KW, Goh SH, Mao HQ, Yang YY. Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions. The Journal of Gene Medicine. 8: 477-87. PMID 16389625 DOI: 10.1002/Jgm.868  0.523
2006 Jiang XS, Chai C, Zhang Y, Zhuo RX, Mao HQ, Leong KW. Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbilical cord blood CD34+ cells. Biomaterials. 27: 2723-32. PMID 16376984 DOI: 10.1016/J.Biomaterials.2005.12.001  0.494
2006 Luong-Van E, Grøndahl L, Chua KN, Leong KW, Nurcombe V, Cool SM. Controlled release of heparin from poly(ε-caprolactone) electrospun fibers Biomaterials. 27: 2042-2050. PMID 16305806 DOI: 10.1016/J.Biomaterials.2005.10.028  0.306
2006 Li Q, Wang J, Shahani S, Sun DD, Sharma B, Elisseeff JH, Leong KW. Biodegradable and photocrosslinkable polyphosphoester hydrogel. Biomaterials. 27: 1027-34. PMID 16125222 DOI: 10.1016/J.Biomaterials.2005.07.019  0.33
2006 Dang JM, Sun DD, Shin-Ya Y, Sieber AN, Kostuik JP, Leong KW. Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells. Biomaterials. 27: 406-18. PMID 16115680 DOI: 10.1016/J.Biomaterials.2005.07.033  0.346
2006 Chen HH, Ho Y, Wang T, Leong KW. 402. Intracellular Trafficking of QD-FRET Nanoparticles for Gene Delivery Molecular Therapy. 13: S154. DOI: 10.1016/J.Ymthe.2006.08.464  0.312
2006 Loo Y, Sampathkumar S, Atukorale PU, Yarema KJ, Leong KW. 356. Engineering of Cell Surface Sialic Acids for Polymeric Gene Delivery Molecular Therapy. 13: S135-S136. DOI: 10.1016/J.Ymthe.2006.08.414  0.603
2006 Jiang X, Dai H, Leong KW, Mao H. 171. PEG-b-PPA/DNA Micelles for Liver Targeted-Gene Delivery Molecular Therapy. 13: S66. DOI: 10.1016/J.Ymthe.2006.08.195  0.519
2006 Klausner EA, Leong KW. 167. Polyethyleneimines as Vehicles for Oral Gene Delivery Molecular Therapy. 13: S64-S65. DOI: 10.1016/J.Ymthe.2006.08.191  0.315
2005 Yim EKF, Leong KW. Significance of synthetic nanostructures in dictating cellular response Nanomedicine: Nanotechnology, Biology and Medicine. 1: 10-21. PMID 17292053 DOI: 10.1016/J.Nano.2004.11.008  0.321
2005 Lu HF, Chua KN, Zhang PC, Lim WS, Ramakrishna S, Leong KW, Mao HQ. Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance. Acta Biomaterialia. 1: 399-410. PMID 16701821 DOI: 10.1016/J.Actbio.2005.04.003  0.498
2005 Lu HF, Lim WS, Zhang PC, Chia SM, Yu H, Mao HQ, Leong KW. Galactosylated poly(vinylidene difluoride) hollow fiber bioreactor for hepatocyte culture. Tissue Engineering. 11: 1667-77. PMID 16411812 DOI: 10.1089/Ten.2005.11.1667  0.626
2005 Wu D, Liu Y, Jiang X, Chen L, He C, Goh SH, Leong KW. Evaluation of hyperbranched poly(amino ester)s of amine constitutions similar to polyethylenimine for DNA delivery. Biomacromolecules. 6: 3166-73. PMID 16283742 DOI: 10.1021/Bm0504983  0.303
2005 Yim EKF, Leong KW. Proliferation and differentiation of human embryonic germ cell derivatives in bioactive polymeric fibrous scaffold Journal of Biomaterials Science-Polymer Edition. 16: 1193-1217. PMID 16268248 DOI: 10.1163/156856205774269485  0.331
2005 Mao HQ, Leong KW. Design of Polyphosphoester-DNA Nanoparticles for Non-Viral Gene Delivery. Advances in Genetics. 53: 275-306. PMID 16243068 DOI: 10.1016/S0065-2660(05)53011-6  0.53
2005 Mao HQ, Leong KW. Design of polyphosphoester-DNA nanoparticles for non-viral gene delivery. Advances in Genetics. 53: 275-306. PMID 16240998  0.466
2005 Chia SM, Lin PC, Quek CH, Yin C, Mao HQ, Leong KW, Xu X, Goh CH, Ng ML, Yu H. Engineering microenvironment for expansion of sensitive anchorage-dependent mammalian cells. Journal of Biotechnology. 118: 434-47. PMID 16026880 DOI: 10.1016/J.Jbiotec.2005.05.012  0.667
2005 Chew SY, Wen J, Yim EK, Leong KW. Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules. 6: 2017-24. PMID 16004440 DOI: 10.1021/Bm0501149  0.3
2005 Liu Y, Wu DC, Zhang WD, Jiang X, He CB, Chung TS, Goh SH, Leong KW. Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA. Angewandte Chemie (International Ed. in English). 44: 4782-5. PMID 15995988 DOI: 10.1002/Anie.200500042  0.318
2005 Liao IC, Wan AC, Yim EK, Leong KW. Controlled release from fibers of polyelectrolyte complexes. Journal of Controlled Release : Official Journal of the Controlled Release Society. 104: 347-58. PMID 15907585 DOI: 10.1016/J.Jconrel.2005.02.013  0.582
2005 Fang N, Tan WJ, Leong KW, Mao HQ, Chan V. pH responsive adhesion of phospholipid vesicle on poly(acrylic acid) cushion grafted to poly(ethylene terephthalate) surface. Colloids and Surfaces. B, Biointerfaces. 42: 245-52. PMID 15893225 DOI: 10.1016/J.Colsurfb.2004.11.002  0.493
2005 Yim EK, Reano RM, Pang SW, Yee AF, Chen CS, Leong KW. Nanopattern-induced changes in morphology and motility of smooth muscle cells. Biomaterials. 26: 5405-13. PMID 15814139 DOI: 10.1016/J.Biomaterials.2005.01.058  0.31
2005 Mao HQ, Shipanova-Kadiyala I, Zhao Z, Dang W, Brown A, Leong KW. Biodegradable poly(terephthalate-co-phosphate)s: synthesis, characterization and drug-release properties. Journal of Biomaterials Science. Polymer Edition. 16: 135-61. PMID 15794482 DOI: 10.1163/1568562053115426  0.512
2005 Zhang XQ, Wang XL, Zhang PC, Liu ZL, Zhuo RX, Mao HQ, Leong KW. Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes. Journal of Controlled Release : Official Journal of the Controlled Release Society. 102: 749-63. PMID 15681095 DOI: 10.1016/J.Jconrel.2004.10.024  0.537
2005 Zhang XQ, Wang XL, Huang SW, Zhuo RX, Liu ZL, Mao HQ, Leong KW. In vitro gene delivery using polyamidoamine dendrimers with a trimesyl core. Biomacromolecules. 6: 341-50. PMID 15638538 DOI: 10.1021/Bm040060N  0.554
2005 Zhang PC, Wang J, Leong KW, Mao HQ. Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups improve transfection efficiency. Biomacromolecules. 6: 54-60. PMID 15638504 DOI: 10.1021/Bm040010I  0.519
2005 Kim MS, Hwang NS, Lee J, Kim TK, Leong K, Shamblott MJ, Gearhart J, Elisseeff J. Musculoskeletal differentiation of cells derived from human embryonic germ cells. Stem Cells (Dayton, Ohio). 23: 113-23. PMID 15625128 DOI: 10.1634/Stemcells.2004-0110  0.328
2005 Chua KN, Lim WS, Zhang P, Lu H, Wen J, Ramakrishna S, Leong KW, Mao HQ. Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold. Biomaterials. 26: 2537-47. PMID 15585256 DOI: 10.1016/J.Biomaterials.2004.07.040  0.52
2005 Tan WJ, Teo GP, Liao K, Leong KW, Mao HQ, Chan V. Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface. Biomaterials. 26: 891-8. PMID 15353200 DOI: 10.1016/J.Biomaterials.2004.03.041  0.49
2005 Leong KW. Polymeric Controlled Nucleic Acid Delivery Mrs Bulletin. 30: 640-646. DOI: 10.1557/Mrs2005.190  0.38
2005 Hu W, Yim EKF, Reano RM, Leong KW, Pang SW. Effects of nanoimprinted patterns in tissue-culture polystyrene on cell behavior Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures. 23: 2984-2989. DOI: 10.1116/1.2121729  0.327
2005 Bowman K, Sarkar R, Raut S, Shah N, Wang X, Mao H, Leong KW. 779. Oral Delivery of Non-Viral DNA Nanoparticles for Hemophilia A Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.319  0.526
2005 Bowman K, Du X, LeVisage C, Sarkar R, Yang X, Leong KW. 200. Factor VIII Gene Expression after Catheter-Based DNA Nanoparticle Delivery Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.203  0.345
2005 Dai H, Jiang X, Chen Y, Mao H, Leong KW. 196. Role of Kupffer Cells in Hepatic Transgene Expression Mediated by Intrabiliary Infusion of Nonviral Vectors Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.199  0.523
2004 Kiang T, Bright C, Cheung CY, Stayton PS, Hoffman AS, Leong KW. Formulation of chitosan-DNA nanoparticles with poly(propyl acrylic acid) enhances gene expression. Journal of Biomaterials Science. Polymer Edition. 15: 1405-21. PMID 15648571 DOI: 10.1163/1568562042368112  0.377
2004 Wan AC, Yim EK, Liao IC, Le Visage C, Leong KW. Encapsulation of biologics in self-assembled fibers as biostructural units for tissue engineering. Journal of Biomedical Materials Research. Part A. 71: 586-95. PMID 15499568 DOI: 10.1002/Jbm.A.30158  0.577
2004 Wen J, Mao HQ, Li W, Lin KY, Leong KW. Biodegradable polyphosphoester micelles for gene delivery. Journal of Pharmaceutical Sciences. 93: 2142-57. PMID 15236461 DOI: 10.1002/Jps.20121  0.541
2004 Wang J, Lee IL, Lim WS, Chia SM, Yu H, Leong KW, Mao HQ. Evaluation of collagen and methylated collagen as gene carriers. International Journal of Pharmaceutics. 279: 115-26. PMID 15234800 DOI: 10.1016/J.Ijpharm.2004.04.014  0.642
2004 Wan AC, Mao HQ, Wang S, Phua SH, Lee GP, Pan J, Lu S, Wang J, Leong KW. Poly(phosphoester) ionomers as tissue-engineering scaffolds. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 70: 91-102. PMID 15199588 DOI: 10.1002/Jbm.B.30022  0.505
2004 Faranesh AZ, Nastley MT, Perez de la Cruz C, Haller MF, Laquerriere P, Leong KW, McVeigh ER. In vitro release of vascular endothelial growth factor from gadolinium-doped biodegradable microspheres. Magnetic Resonance in Medicine. 51: 1265-71. PMID 15170848 DOI: 10.1002/Mrm.20092  0.307
2004 Kiang T, Wen J, Lim HW, Leong KW. The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. Biomaterials. 25: 5293-301. PMID 15110480 DOI: 10.1016/J.Biomaterials.2003.12.036  0.357
2004 Chan V, Liu KK, Le Visage C, Ju BF, Leong KW. Bioadhesive characterization of poly(methylidene malonate 2.12) microparticle on model extracellular matrix. Biomaterials. 25: 4327-32. PMID 15046923 DOI: 10.1016/J.Biomaterials.2003.11.021  0.31
2004 Quek CH, Li J, Sun T, Chan ML, Mao HQ, Gan LM, Leong KW, Yu H. Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation. Biomaterials. 25: 3531-40. PMID 15020127 DOI: 10.1016/J.Biomaterials.2003.09.112  0.647
2004 Huang SW, Wang J, Zhang PC, Mao HQ, Zhuo RX, Leong KW. Water-soluble and nonionic polyphosphoester: synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle. Biomacromolecules. 5: 306-11. PMID 15002988 DOI: 10.1021/Bm034241L  0.525
2004 Visage CL, Rioux-Leclercq N, Haller M, Breton P, Malavaud B, Leong K. Efficacy of paclitaxel released from bio-adhesive polymer microspheres on model superficial bladder cancer. The Journal of Urology. 171: 1324-1329. PMID 14767342 DOI: 10.1097/01.Ju.0000103922.12319.59  0.314
2004 Li Y, Wang J, Lee CG, Wang CY, Gao SJ, Tang GP, Ma YX, Yu H, Mao HQ, Leong KW, Wang S. CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes. Gene Therapy. 11: 109-14. PMID 14681704 DOI: 10.1038/Sj.Gt.3302135  0.565
2004 Li Q, Williams CG, Sun DD, Wang J, Leong K, Elisseeff JH. Photocrosslinkable polysaccharides based on chondroitin sulfate. Journal of Biomedical Materials Research. Part A. 68: 28-33. PMID 14661246 DOI: 10.1002/Jbm.A.20007  0.338
2004 Wan ACA, Liao IC, Yim EKF, Leong KW. Mechanism of fiber formation by interfacial polyelectrolyte complexation Macromolecules. 37: 7019-7025. DOI: 10.1021/Ma0498868  0.551
2004 Bowman K, Sarkar R, Wang X, Mao H, Leong KW. 828. Evaluation of Non-Viral Vectors for Gene Therapy of Hemophilia A Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.728  0.535
2004 Dai H, Jiang X, Lim W, Jiang X, Chen Y, Mao H, Leong KW. 357. Selective Depletion of Kupffer Cells Leads to Enhanced Transgene Expression in Rat Liver Following Intraductal Infusion of Naked DNA and DNA Nanoparticles Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.284  0.524
2003 Yin C, Ying L, Zhang PC, Zhuo RX, Kang ET, Leong KW, Mao HQ. High density of immobilized galactose ligand enhances hepatocyte attachment and function. Journal of Biomedical Materials Research. Part A. 67: 1093-104. PMID 14624494 DOI: 10.1002/Jbm.A.10033  0.491
2003 Lu HF, Lim WS, Wang J, Tang ZQ, Zhang PC, Leong KW, Chia SM, Yu H, Mao HQ. Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance. Biomaterials. 24: 4893-903. PMID 14559002 DOI: 10.1016/S0142-9612(03)00404-6  0.62
2003 Wang J, Huang SW, Zhang PC, Mao HQ, Leong KW. Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters. International Journal of Pharmaceutics. 265: 75-84. PMID 14522120 DOI: 10.1016/J.Ijpharm.2003.07.006  0.515
2003 Sun T, Chan ML, Zhou Y, Xu X, Zhang J, Lao X, Wang X, Quek CH, Chen JP, Leong KW, Yu H. Use of ultrathin shell microcapsules of hepatocytes in bioartificial liver-assist device. Tissue Engineering. 9: S65-75. PMID 14511471 DOI: 10.1089/10763270360696987  0.521
2003 Wen J, Kim GJ, Leong KW. Poly(D,L-lactide-co-ethyl ethylene phosphate)s as new drug carriers. Journal of Controlled Release : Official Journal of the Controlled Release Society. 92: 39-48. PMID 14499184 DOI: 10.1016/S0168-3659(03)00294-3  0.349
2003 Salem AK, Searson PC, Leong KW. Multifunctional nanorods for gene delivery. Nature Materials. 2: 668-71. PMID 12970757 DOI: 10.1038/Nmat974  0.363
2003 Du X, Yang Y, Le Visage C, Chen HH, DeJong R, Qiu B, Wang D, Leong KW, Hamper UM, Yang X. In vivo US monitoring of catheter-based vascular delivery of gene microspheres in pigs: feasibility. Radiology. 228: 555-9. PMID 12893906 DOI: 10.1148/Radiol.2282020539  0.321
2003 Chew JL, Wolfowicz CB, Mao HQ, Leong KW, Chua KY. Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. Vaccine. 21: 2720-9. PMID 12798609 DOI: 10.1016/S0264-410X(03)00228-7  0.477
2003 Li J, Ni X, Leong KW. Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide)s and alpha-cyclodextrin. Journal of Biomedical Materials Research. Part A. 65: 196-202. PMID 12734812 DOI: 10.1002/Jbm.A.10444  0.336
2003 Zhao Z, Wang J, Mao HQ, Leong KW. Polyphosphoesters in drug and gene delivery. Advanced Drug Delivery Reviews. 55: 483-99. PMID 12706047 DOI: 10.1016/S0169-409X(03)00040-1  0.546
2003 Xu X, Yee WC, Hwang PY, Yu H, Wan AC, Gao S, Boon KL, Mao HQ, Leong KW, Wang S. Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits. Biomaterials. 24: 2405-12. PMID 12699678 DOI: 10.1016/S0142-9612(03)00109-1  0.614
2003 Yin C, Mien Chia S, Hoon Quek C, Yu H, Zhuo RX, Leong KW, Mao HQ. Microcapsules with improved mechanical stability for hepatocyte culture. Biomaterials. 24: 1771-80. PMID 12593959 DOI: 10.1016/S0142-9612(02)00580-X  0.644
2003 Yin C, Liao K, Mao HQ, Leong KW, Zhuo RX, Chan V. Adhesion contact dynamics of HepG2 cells on galactose-immobilized substrates. Biomaterials. 24: 837-50. PMID 12485802 DOI: 10.1016/S0142-9612(02)00416-7  0.513
2003 Fang N, Wang J, Mao HQ, Leong KW, Chan V. BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer Colloids and Surfaces B: Biointerfaces. 29: 233-245. DOI: 10.1016/S0927-7765(02)00207-2  0.481
2002 Wang J, Zhang PC, Lu HF, Ma N, Wang S, Mao HQ, Leong KW. New polyphosphoramidate with a spermidine side chain as a gene carrier. Journal of Controlled Release : Official Journal of the Controlled Release Society. 83: 157-68. PMID 12220847 DOI: 10.1016/S0168-3659(02)00180-3  0.534
2002 Xu X, Yu H, Gao S, Ma HQ, Leong KW, Wang S. Polyphosphoester microspheres for sustained release of biologically active nerve growth factor. Biomaterials. 23: 3765-72. PMID 12109702 DOI: 10.1016/S0142-9612(02)00116-3  0.544
2002 Chia SM, Wan AC, Quek CH, Mao HQ, Xu X, Shen L, Ng ML, Leong KW, Yu H. Multi-layered microcapsules for cell encapsulation. Biomaterials. 23: 849-56. PMID 11774851 DOI: 10.1016/S0142-9612(01)00191-0  0.662
2002 Kim S, Visage CL, Tateno K, Sieber A, Kostuik J, Leong K. Interaction of human mescenchymal stem cells with disc cells The Spine Journal. 2: 107-108. DOI: 10.1016/S1529-9430(02)00264-4  0.325
2002 Fang N, Chan V, Wan KT, Mao HQ, Leong KW. Colloidal adhesion of phospholipid vesicles: High-resolution reflection interference contrast microscopy and theory Colloids and Surfaces B: Biointerfaces. 25: 347-362. DOI: 10.1016/S0927-7765(01)00336-8  0.473
2001 Fang N, Chan V, Mao HQ, Leong KW. Interactions of phospholipid bilayer with chitosan: Effect of molecular weight and pH Biomacromolecules. 2: 1161-1168. PMID 11777388 DOI: 10.1021/Bm015548S  0.486
2001 Wang J, Mao HQ, Leong KW. A novel biodegradable gene carrier based on polyphosphoester. Journal of the American Chemical Society. 123: 9480-1. PMID 11562246 DOI: 10.1021/Ja016062M  0.485
2001 Wang S, Ma N, Gao SJ, Yu H, Leong KW. Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 658-64. PMID 11356070 DOI: 10.1006/Mthe.2001.0324  0.547
2001 Wang S, Wan AC, Xu X, Gao S, Mao HQ, Leong KW, Yu H. A new nerve guide conduit material composed of a biodegradable poly(phosphoester). Biomaterials. 22: 1157-69. PMID 11352095 DOI: 10.1016/S0142-9612(00)00356-2  0.636
2001 Wan AC, Mao HQ, Wang S, Leong KW, Ong LK, Yu H. Fabrication of poly(phosphoester) nerve guides by immersion precipitation and the control of porosity. Biomaterials. 22: 1147-56. PMID 11352094 DOI: 10.1016/S0142-9612(00)00355-0  0.621
2001 Mao HQ, Roy K, Troung-Le VL, Janes KA, Lin KY, Wang Y, August JT, Leong KW. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. Journal of Controlled Release : Official Journal of the Controlled Release Society. 70: 399-421. PMID 11182210 DOI: 10.1016/S0168-3659(00)00361-8  0.54
2000 Gutsche AT, Zurlo J, Deyesu E, Leong KW. Rat hepatocyte morphology and function on lactose-derivatized polystyrene surfaces. Biotechnology and Bioengineering. 49: 259-265. PMID 18623576 DOI: 10.1002/(Sici)1097-0290(19960205)49:3<259::Aid-Bit3>3.0.Co;2-J  0.302
2000 Chia SM, Leong KW, Li J, Xu X, Zeng K, Er PN, Gao S, Yu H. Hepatocyte encapsulation for enhanced cellular functions. Tissue Engineering. 6: 481-95. PMID 11074935 DOI: 10.1089/107632700750022134  0.545
2000 Georgantas RW, Leong KW, August JT. Antigen-specific induction of peripheral T cell tolerance in vivo by codelivery of DNA vectors encoding antigen and Fas ligand. Human Gene Therapy. 11: 851-8. PMID 10779162 DOI: 10.1089/10430340050015464  0.316
1999 Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy Nature Medicine. 5: 387-391. PMID 10202926 DOI: 10.1038/7385  0.509
1999 Kalyanasundaram S, Feinstein S, Nicholson JP, Leong KW, Garver RI. Coacervate microspheres as carriers of recombinant adenoviruses Cancer Gene Therapy. 6: 107-112. PMID 10195878 DOI: 10.1038/Sj.Cgt.7700025  0.318
1999 Truong-Le VL, Walsh SM, Schweibert E, Mao HQ, Guggino WB, August JT, Leong KW. Gene transfer by DNA-gelatin nanospheres. Archives of Biochemistry and Biophysics. 361: 47-56. PMID 9882427 DOI: 10.1006/Abbi.1998.0975  0.527
1998 Brown KE, Leong K, Huang CH, Dalal R, Green GD, Haimes HB, Jimenez PA, Bathon J. Gelatin/chondroitin 6-sulfate microspheres for the delivery of therapeutic proteins to the joint. Arthritis and Rheumatism. 41: 2185-95. PMID 9870875 DOI: 10.1002/1529-0131(199812)41:12<2185::Aid-Art13>3.0.Co;2-C  0.32
1998 Leong KW, Mao HQ, Truong-Le VL, Roy K, Walsh SM, August JT. DNA-polycation nanospheres as non-viral gene delivery vehicles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 53: 183-93. PMID 9741926 DOI: 10.1016/S0168-3659(97)00252-6  0.364
1998 Truong-Le VL, August JT, Leong KW. Controlled gene delivery by DNA-gelatin nanospheres. Human Gene Therapy. 9: 1709-17. PMID 9721081 DOI: 10.1089/Hum.1998.9.12-1709  0.35
1996 Lo H, Kadiyala S, Guggino SE, Leong KW. Poly(L-lactic acid) foams with cell seeding and controlled-release capacity Journal of Biomedical Materials Research. 30: 475-484. PMID 8847355 DOI: 10.1002/(Sici)1097-4636(199604)30:4<475::Aid-Jbm5>3.0.Co;2-M  0.375
1996 Lesser GJ, Grossman SA, Leong KW, Lo H, Eller S. In vitro and in vivo studies of subcutaneous hydromorphone implants designed for the treatment of cancer pain. Pain. 65: 265-72. PMID 8826516 DOI: 10.1016/0304-3959(95)00248-0  0.316
1996 Gutsche AT, Lo H, Zurlo J, Yager J, Leong KW. Engineering of a sugar-derivatized porous network for hepatocyte culture Biomaterials. 17: 387-393. PMID 8745336 DOI: 10.1016/0142-9612(96)85577-3  0.318
1995 Truong VL, Williams JR, Hildreth JEK, Leong KW. Targeted delivery of immunomicrospheresin vivo Drug Delivery. 2: 166-174. DOI: 10.3109/10717549509031366  0.335
1995 Brown KE, Bathon J, Huang CH, Dalai R, Leong KW. Cationic Gelatin as a Gene Carrier Mrs Proceedings. 394. DOI: 10.1557/Proc-394-61  0.34
1995 Shao W, Leong KW. Enzymatically Degradable Synthetic Polymers Mrs Proceedings. 394. DOI: 10.1557/Proc-394-199  0.325
1995 Dahiyat BI, Posadas EM, Hirosue S, Hostin E, Leong KW. Degradable biomaterials with elastomeric characteristics and drug-carrier function Reactive Polymers. 25: 101-109. DOI: 10.1016/0923-1137(95)91297-P  0.322
1995 Dahiyat B, Richards M, Leong K. Controlled release from poly(phosphoester) matrices Journal of Controlled Release. 33: 13-21. DOI: 10.1016/0168-3659(94)00039-W  0.322
1993 Dahiyat BI, Hostin E, Posadas EM, Leong KW. Synthesis and characterization of putrescine-based poly(phosphoester-urethanes). Journal of Biomaterials Science. Polymer Edition. 4: 529-43. PMID 8241068 DOI: 10.1163/156856293X00186  0.306
1993 Gutsche AT, Zurlo J, Lo H, Leong KW. Synthesis and Characterization of Polymer Substrates for Rat H Epatocyte Culture Mrs Proceedings. 330. DOI: 10.1557/Proc-330-243  0.322
1991 Saltzman WM, Parsons-Wingerter P, Leong KW, Lin S. Fibroblast and hepatocyte behavior on synthetic polymer surfaces Journal of Biomedical Materials Research. 25: 741-759. PMID 1874758 DOI: 10.1002/Jbm.820250605  0.512
1991 Richards M, Dahiyat BI, Arm DM, Brown PR, Leong KW. Evaluation of polyphosphates and polyphosphonates as degradable biomaterials. Journal of Biomedical Materials Research. 25: 1151-67. PMID 1778999 DOI: 10.1002/Jbm.820250908  0.31
1989 Leong KW, Brott BC, Langer R. Bioerodible polyanhydrides as drug-carrier matrices. I: Characterization, degradation, and release characteristics. Journal of Biomedical Materials Research. 19: 941-55. PMID 3880353 DOI: 10.1002/Jbm.820190806  0.443
1989 Kost J, Leong K, Langer R. Ultrasound-enhanced polymer degradation and release of incorporated substances. Proceedings of the National Academy of Sciences of the United States of America. 86: 7663-6. PMID 2813349 DOI: 10.1073/Pnas.86.20.7663  0.413
1988 Bindschaedler C, Leong K, Mathiowitz E, Langer R. Polyanhydride microsphere formulation by solvent extraction Journal of Pharmaceutical Sciences. 77: 696-698. PMID 3210160 DOI: 10.1002/Jps.2600770811  0.388
1988 Leong K, Langer R. Polymeric controlled drug delivery Advanced Drug Delivery Reviews. 1: 199-233. DOI: 10.1016/0169-409X(88)90019-1  0.419
1988 Kost J, Leong K, Langer R. Ultrasonically controlled polymeric drug delivery Makromolekulare Chemie. Macromolecular Symposia. 19: 275-285. DOI: 10.1002/Masy.19880190122  0.44
1987 Leong KW, Simonte V, Langer R. Synthesis of polyanhydrides: melt-polycondensation, dehydrochlorination, and dehydrative coupling Macromolecules. 20: 705-712. DOI: 10.1021/Ma00170A001  0.335
1986 Leong KW, Kost J, Mathiowitz E, Langer R. Polyanhydrides for controlled release of bioactive agents Biomaterials. 7: 364-371. PMID 3778996 DOI: 10.1016/0142-9612(86)90007-4  0.444
1985 Langer R, Siegel R, Brown L, Leong K, Kost J, Edelman E. Controlled release and magnetically modulated systems for macromolecular drugs. Annals of the New York Academy of Sciences. 446: 1-13. PMID 3893280 DOI: 10.1111/J.1749-6632.1985.Tb18386.X  0.635
1985 Langer R, Lund D, Leong K, Folkman J. Controlled release of macromolecules: Biological studies Journal of Controlled Release. 2: 331-341. DOI: 10.1016/0168-3659(85)90055-0  0.413
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