Kevin M. Haigis, Ph.D.
Affiliations: | 2002 | University of Wisconsin, Madison, Madison, WI |
Area:
Genetics, OncologyGoogle:
"Kevin Haigis"Parents
Sign in to add mentor| William F. Dove | grad student | 1996-2002 | UW Madison | |
| (Somatic transmission genetics and intestinal tumorigenesis in Apc(Min)/+MICE.) | ||||
| Tyler Jacks | post-doc | 2002-2007 | MIT | |
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Publications
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| Loi P, Schade AE, Rodriguez CL, et al. (2024) Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers. Cancer Discovery |
| Yang MH, Tran TH, Hunt B, et al. (2023) Allosteric regulation of switch-II domain controls KRAS oncogenicity. Cancer Research |
| Huynh MV, Hobbs GA, Schaefer A, et al. (2022) Functional and biological heterogeneity of KRAS mutations. Science Signaling. 15: eabn2694 |
| Johnson C, Burkhart DL, Haigis KM. (2022) Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention. Cancer Discovery. 12: 913-923 |
| Ferguson FM, Nabet B, Raghavan S, et al. (2020) Discovery of a selective inhibitor of doublecortin like kinase 1. Nature Chemical Biology |
| Zambetti NA, Firestone AJ, Remsberg JR, et al. (2020) Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood |
| Haigis K. (2020) Abstract IA29: Global proteomics reveals the context-dependence of K-Ras signaling Molecular Cancer Research. 18 |
| Zambetti NA, Firestone AJ, Wong JC, et al. (2020) Abstract A25: In vivo evidence validating the palmitoylation/depalmitoylation cycle as a therapeutic target in NRAS mutant hematologic cancers Molecular Cancer Research. 18 |
| Lin Y, Dischinger P, Graveel C, et al. (2020) Abstract A18: Characterization of K-RasG13D as a unique activating allele in a mouse model of colorectal cancer Molecular Cancer Research. 18 |
| Yang MH, Hunt B, Johnson C, et al. (2020) Abstract B47: Mutation of K104 abrogates the oncogenic properties of K-RasG12D Cancer Research. 80 |