Kevin M. Haigis, Ph.D.

2002 University of Wisconsin, Madison, Madison, WI 
Genetics, Oncology
"Kevin Haigis"


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William F. Dove grad student 1996-2002 UW Madison
 (Somatic transmission genetics and intestinal tumorigenesis in Apc(Min)/+MICE.)
Tyler Jacks post-doc 2002-2007 MIT
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Poulin EJ, Bera AK, Lu J, et al. (2019) Tissue-specific oncogenic activity of K-RasA146T. Cancer Discovery
Lyons J, Ghazi PC, Starchenko A, et al. (2018) The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. Plos Biology. 16: e2002417
Gierut JJ, Wood LB, Lau KS, et al. (2015) Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Science Signaling. 8: ra129
Wood LB, Winslow AR, Proctor EA, et al. (2015) Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Scientific Reports. 5: 16622
Gierut JJ, Lyons J, Shah MS, et al. (2015) Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Research. 15: 165-71
Depeille P, Henricks LM, van de Ven RA, et al. (2015) RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nature Cell Biology. 17: 804-15
Bender RH, Haigis KM, Gutmann DH. (2015) Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner. Stem Cells (Dayton, Ohio). 33: 1998-2010
Tsai FD, Lopes MS, Zhou M, et al. (2015) K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proceedings of the National Academy of Sciences of the United States of America. 112: 779-84
Burgess MR, Hwang E, Firestone AJ, et al. (2014) Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 124: 3947-55
Jun HJ, Roy J, Smith TB, et al. (2014) ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology. 155: 3661-73
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