| Year |
Citation |
Score |
| 2024 |
Bhosale S, Kandalkar S, Gilormini PA, Akintola O, Rowland R, Adabala PJP, King D, Deen MC, Chen X, Davies GJ, Vocadlo DJ, Bennet AJ. Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates. Acs Catalysis. 14: 14769-14779. PMID 39386917 DOI: 10.1021/acscatal.4c04549 |
0.316 |
|
| 2024 |
Rivero-Barbarroja G, Carmen Padilla-Pérez M, Maisonneuve S, Isabel García-Moreno M, Tiet B, Vocadlo DJ, Xie J, García Fernández JM, Ortiz Mellet C. sp-Iminosugar azobenzene O-glycosides: Light-sensitive glycosidase inhibitors with unprecedented tunability and switching factors. Bioorganic Chemistry. 150: 107555. PMID 38885548 DOI: 10.1016/j.bioorg.2024.107555 |
0.304 |
|
| 2023 |
Calvelo M, Males A, Alteen MG, Willems LI, Vocadlo DJ, Davies GJ, Rovira C. Human -GlcNAcase Uses a Preactivated Boat-skew Substrate Conformation for Catalysis. Evidence from X-ray Crystallography and QM/MM Metadynamics. Acs Catalysis. 13: 13672-13678. PMID 37969138 DOI: 10.1021/acscatal.3c02378 |
0.375 |
|
| 2023 |
Pratt MR, Vocadlo DJ. Understanding and exploiting the roles of O-GlcNAc in neurodegenerative diseases. The Journal of Biological Chemistry. 299: 105411. PMID 37918804 DOI: 10.1016/j.jbc.2023.105411 |
0.418 |
|
| 2023 |
Escobar EE, Seeley EH, Serrano-Negrón JE, Vocadlo DJ, Brodbelt JS. In Situ Imaging of O-Linked β-N-Acetylglucosamine Using On-Tissue Hydrolysis and MALDI Mass Spectrometry. Cancers. 15. PMID 36831567 DOI: 10.3390/cancers15041224 |
0.354 |
|
| 2022 |
Doherty GG, Ler GJM, Wimmer N, Bernhardt PV, Ashmus RA, Vocadlo DJ, Armstrong ZWB, Davies GJ, Maccarana M, Li JP, Kayal Y, Ferro V. Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of α-Iduronidase, β-Glucuronidase and Heparanase. Chembiochem : a European Journal of Chemical Biology. PMID 36453606 DOI: 10.1002/cbic.202200619 |
0.588 |
|
| 2022 |
Meek RW, Brockerman J, Fordwour OB, Zandberg WF, Davies GJ, Vocadlo DJ. The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity. Plos Biology. 20: e3001764. PMID 36129849 DOI: 10.1371/journal.pbio.3001764 |
0.672 |
|
| 2022 |
Santana A, Robinson K, Vickers C, Deen M, Chen HM, Zhou S, Dai B, Fuller M, Boraston A, Vocadlo D, Clarke L, Withers S. Pharmacological Chaperones for GCase That Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models. Angewandte Chemie (International Ed. in English). PMID 35864061 DOI: 10.1002/anie.202207974 |
0.438 |
|
| 2022 |
King DT, Serrano-Negrón JE, Zhu Y, Moore CL, Shoulders MD, Foster LJ, Vocadlo DJ. Thermal Proteome Profiling Reveals the O-GlcNAc-Dependent Meltome. Journal of the American Chemical Society. PMID 35230102 DOI: 10.1021/jacs.1c10621 |
0.327 |
|
| 2022 |
Cecioni S, Ashmus RA, Gilormini PA, Zhu S, Chen X, Shan X, Gros C, Deen MC, Wang Y, Britton R, Vocadlo DJ. Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates. Nature Chemical Biology. PMID 35210619 DOI: 10.1038/s41589-021-00960-x |
0.733 |
|
| 2022 |
Ahmed O, Affar M, Masclef L, Echbicheb M, Gushul-Leclaire M, Estavoyer B, Vocadlo DJ, Affar EB. Immunoprecipitation and Western blot-based detection of protein O-GlcNAcylation in cells. Star Protocols. 3: 101108. PMID 35106498 DOI: 10.1016/j.xpro.2021.101108 |
0.342 |
|
| 2022 |
González-Cuesta M, Sidhu P, Ashmus RA, Males A, Proceviat C, Madden Z, Rogalski JC, Busmann JA, Foster LJ, García Fernández JM, Davies GJ, Ortiz Mellet C, Vocadlo DJ. Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications. Journal of the American Chemical Society. 144: 832-844. PMID 34985906 DOI: 10.1021/jacs.1c10504 |
0.818 |
|
| 2021 |
Meek RW, Blaza JN, Busmann JA, Alteen MG, Vocadlo DJ, Davies GJ. Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT. Nature Communications. 12: 6508. PMID 34764280 DOI: 10.1038/s41467-021-26796-6 |
0.321 |
|
| 2021 |
Alteen MG, Tan HY, Vocadlo DJ. Monitoring and modulating O-GlcNAcylation: assays and inhibitors of O-GlcNAc processing enzymes. Current Opinion in Structural Biology. 68: 157-165. PMID 33535148 DOI: 10.1016/j.sbi.2020.12.008 |
0.465 |
|
| 2020 |
Zhu Y, Willems LI, Salas D, Cecioni S, Wu WB, Foster LJ, Vocadlo DJ. Tandem Bioorthogonal Labeling Uncovers Endogenous Cotranslationally -GlcNAc Modified Nascent Proteins. Journal of the American Chemical Society. PMID 32870666 DOI: 10.1021/Jacs.0C04121 |
0.718 |
|
| 2020 |
Escobar E, King D, Serrano Negron J, Alteen MG, Vocadlo DJ, Brodbelt JS. Precision Mapping of O-Linked N-Acetylglucosamine Sites in Proteins using Ultraviolet Photodissociation Mass Spectrometry. Journal of the American Chemical Society. PMID 32510947 DOI: 10.1021/Jacs.0C04710 |
0.436 |
|
| 2020 |
Wang X, Li W, Marcus J, Pearson M, Song L, Smith K, Terracina G, Lee J, Hong KK, Lu SX, Hyde L, Chen SC, Kinsley D, Melchor JP, Rubins DJ, ... ... Vocadlo DJ, et al. MK-8719, a novel and selective O-GlcNAcase inhibitor that reduces the formation of pathological tau and ameliorates neurodegeneration in a mouse model of tauopathy. The Journal of Pharmacology and Experimental Therapeutics. PMID 32493725 DOI: 10.1124/Jpet.120.266122 |
0.364 |
|
| 2020 |
Tavassoly O, Yue J, Vocadlo DJ. Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils. The Febs Journal. PMID 32365408 DOI: 10.1111/Febs.15349 |
0.4 |
|
| 2020 |
Deen MC, Proceviat C, Shan X, Wu L, Shen DL, Davies GJ, Vocadlo DJ. Selective fluorogenic β-glucocerebrosidase substrates for convenient analysis of enzyme activity in cell and tissue homogenates. Acs Chemical Biology. PMID 32109051 DOI: 10.1021/Acschembio.9B01044 |
0.382 |
|
| 2020 |
Vocadlo DJ, Alteen MG, Gros C, Meek R, Cardoso DA, Busmann J, Sangouard G, Deen MC, Tan HY, Shen DL, Russell CC, Davies GJ, Robinson PJ, McCluskey A. A direct fluorescent activity assay for glycosyltransferases enables convenient high-throughput screening: Application to O-GlcNAc Transferase. Angewandte Chemie (International Ed. in English). PMID 32092778 DOI: 10.1002/Anie.202000621 |
0.414 |
|
| 2020 |
Wong KKL, Liu TW, Parker JM, Sinclair DAR, Chen YY, Khoo KH, Vocadlo DJ, Verheyen EM. The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in . Proceedings of the National Academy of Sciences of the United States of America. PMID 31932432 DOI: 10.1073/Pnas.1912894117 |
0.318 |
|
| 2020 |
Vocadlo D, Overkleeft H. A round up on some of the latest in the chemistry and biology of carbohydrates and carbohydrate-processing enzymes. Current Opinion in Chemical Biology. 53: A1-A3. PMID 31864526 DOI: 10.1016/J.Cbpa.2019.11.010 |
0.374 |
|
| 2019 |
King DT, Males A, Davies GJ, Vocadlo DJ. Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)-processing enzymes. Current Opinion in Chemical Biology. 53: 131-144. PMID 31654859 DOI: 10.1016/J.Cbpa.2019.09.001 |
0.531 |
|
| 2019 |
Selnick H, Hess JF, Tang C, Liu K, Schachter J, Ballard JE, Marcus JN, Klein DJ, Wang X, Pearson M, Savage MJ, Kaul R, Li T, Vocadlo DJ, Zhou Y, et al. Discovery of MK-8719, A Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. Journal of Medicinal Chemistry. PMID 31487175 DOI: 10.1021/Acs.Jmedchem.9B01090 |
0.358 |
|
| 2019 |
Makwana V, Ryan P, Patel B, Alteen M, Dukie SA, Vocadlo DJ, Rudrawar S. Essential role of O-GlcNAcylation in stabilization of oncogenic factors. Biochimica Et Biophysica Acta. General Subjects. PMID 31034911 DOI: 10.1016/J.Bbagen.2019.04.002 |
0.402 |
|
| 2019 |
Mangat CS, Vadlamani G, Holicek V, Chu M, Larmour V, Vocadlo DJ, Mulvey MR, Mark BL. Molecular basis for the potent inhibition of the emerging carbapenemase VCC-1 by avibactam. Antimicrobial Agents and Chemotherapy. PMID 30782990 DOI: 10.1128/Aac.02112-18 |
0.341 |
|
| 2019 |
Lichtenstein ML, Fallah N, Feldman HH, Mackenzie IR, Vocadlo D. P2-168: IMMUNOHISTOCHEMISTRY OF O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE (OGT) AND AUTOPHAGY MARKER LC3B IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P640-P641. DOI: 10.1016/J.Jalz.2019.06.2575 |
0.325 |
|
| 2018 |
Tan HY, Eskandari R, Shen D, Zhu Y, Liu TW, Willems LI, Alteen MG, Madden Z, Vocadlo DJ. Direct one-step fluorescent labeling of O-GlcNAc modified proteins in live cells using metabolic intermediates. Journal of the American Chemical Society. PMID 30296064 DOI: 10.1021/Jacs.8B08260 |
0.499 |
|
| 2018 |
Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA. A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa. Chemical Communications (Cambridge, England). PMID 30178799 DOI: 10.2210/Pdb6Dte/Pdb |
0.322 |
|
| 2018 |
Tavassoly O, Sade D, Bera S, Shaham-Niv S, Vocadlo DJ, Gazit E. Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation. Journal of Molecular Biology. PMID 30098337 DOI: 10.1016/J.Jmb.2018.08.002 |
0.301 |
|
| 2018 |
Liu TW, Zandberg WF, Gloster TM, Deng L, Murray KD, Shan X, Vocadlo DJ. Metabolic inhibitors of O-GlcNAc transferase (OGT) that act in vivo implicate decreased O-GlcNAc levels in leptin-mediated nutrient sensing. Angewandte Chemie (International Ed. in English). PMID 29756380 DOI: 10.1002/Anie.201803254 |
0.76 |
|
| 2018 |
Zhu Y, Shan X, Safarpour F, Erro Go N, Li N, Shan A, Huang M, Deen M, Holicek V, Ashmus R, Madden Z, Gorski S, Silverman M, Vocadlo DJ. Pharmacological inhibition of O-GlcNAcase (OGA) enhances autophagy in brain through an mTOR-independent pathway. Acs Chemical Neuroscience. PMID 29460617 DOI: 10.1021/Acschemneuro.8B00015 |
0.454 |
|
| 2018 |
Ashmus RA, Shen DL, Vocadlo DJ. Fluorescence-Quenched Substrates for Quantitative Live Cell Imaging of Glucocerebrosidase Activity. Methods in Enzymology. 598: 199-215. PMID 29306435 DOI: 10.1016/Bs.Mie.2017.06.014 |
0.35 |
|
| 2018 |
Abbott W, Alber O, Bayer E, Berrin J, Boraston A, Brumer H, Brzezinski R, Clarke A, Cobucci-Ponzano B, Cockburn D, Coutinho P, Czjzek M, Dassa B, Davies GJ, Eijsink V, ... ... Vocadlo D, et al. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes Glycobiology. 28: 3-8. PMID 29040563 DOI: 10.1093/Glycob/Cwx089 |
0.758 |
|
| 2018 |
Seo IK, Woo EH, Cecioni S, Vocadlo DJ. A divergent synthesis to generate targeted libraries of inhibitors for endo-N-acetylglucosaminidases Canadian Journal of Chemistry. 96: 248-254. DOI: 10.1139/Cjc-2017-0461 |
0.746 |
|
| 2017 |
Cecioni S, Vocadlo DJ. Carbohydrate Bis-acetal-Based Substrates as Tunable Fluorescence-Quenched Probes for Monitoring exo-Glycosidase Activity. Journal of the American Chemical Society. PMID 28631482 DOI: 10.1021/Jacs.7B01948 |
0.746 |
|
| 2017 |
Hastings NB, Wang X, Song L, Butts BD, Grotz D, Hargreaves R, Fred Hess J, Hong KK, Huang CR, Hyde L, Laverty M, Lee J, Levitan D, Lu SX, Maguire M, ... ... Vocadlo DJ, et al. Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice. Molecular Neurodegeneration. 12: 39. PMID 28521765 DOI: 10.1186/S13024-017-0181-0 |
0.464 |
|
| 2017 |
Bouquet J, King DT, Vadlamani G, Benzie GR, Iorga B, Ide D, Adachi I, Kato A, Vocadlo DJ, Mark BL, Blériot Y, Désiré J. Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics. Organic & Biomolecular Chemistry. PMID 28513749 DOI: 10.1039/C7Ob00838D |
0.381 |
|
| 2017 |
Vadlamani G, Stubbs KA, Désiré J, Blériot Y, Vocadlo DJ, Mark BL. Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance. Protein Science : a Publication of the Protein Society. PMID 28370529 DOI: 10.1002/Pro.3166 |
0.429 |
|
| 2017 |
Roth C, Chan S, Offen WA, Hemsworth GR, Willems LI, King DT, Varghese V, Britton R, Vocadlo DJ, Davies GJ. Structural and functional insight into human O-GlcNAcase. Nature Chemical Biology. PMID 28346405 DOI: 10.1038/nchembio.2358 |
0.504 |
|
| 2017 |
Yuzwa SA, Vocadlo DJ. Production of O-GlcNAc Modified Recombinant Tau in E. coli and Detection of Ser400 O-GlcNAc Tau In Vivo. Methods in Molecular Biology (Clifton, N.J.). 1523: 237-248. PMID 27975253 DOI: 10.1007/978-1-4939-6598-4_13 |
0.44 |
|
| 2016 |
Cekic N, Heinonen JE, Stubbs KA, Roth C, He Y, Bennet AJ, McEachern EJ, Davies GJ, Vocadlo DJ. Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human -GlcNAcase. Chemical Science. 7: 3742-3750. PMID 29997861 DOI: 10.1039/C6Sc00370B |
0.396 |
|
| 2016 |
Shen DL, Liu TW, Zandberg W, Clark T, Eskandari R, Alteen MG, Tan HY, Zhu Y, Cecioni S, Vocadlo D. Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose. Acs Chemical Biology. PMID 27935279 DOI: 10.1021/Acschembio.6B00876 |
0.817 |
|
| 2016 |
Liu TW, Myschyshyn M, Sinclair DA, Cecioni S, Beja K, Honda BM, Morin RD, Vocadlo DJ. Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster. Nature Chemical Biology. PMID 27918560 DOI: 10.1038/Nchembio.2247 |
0.755 |
|
| 2016 |
Alteen MG, Oehler V, Nemčovičová I, Wilson IB, Vocadlo DJ, Gloster TM. Mechanism of Human Nucleocytoplasmic Hexosaminidase D. Biochemistry. PMID 27149221 DOI: 10.1021/Acs.Biochem.5B01285 |
0.442 |
|
| 2016 |
Noach I, Pluvinage B, Laurie C, Abe KT, Alteen MG, Vocadlo DJ, Boraston AB. The details of glycolipid glycan hydrolysis by the structural analysis of a family 123 glycoside hydrolase from Clostridium perfringens. Journal of Molecular Biology. PMID 27038508 DOI: 10.1016/J.Jmb.2016.03.020 |
0.414 |
|
| 2016 |
Hattie M, Cekic N, Debowski AW, Vocadlo DJ, Stubbs KA. Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases. Organic & Biomolecular Chemistry. PMID 26924385 DOI: 10.1039/C6Ob00297H |
0.334 |
|
| 2016 |
Smith SM, Struyk A, Jonathan D, Declercq R, Marcus J, Toolan D, Wang X, Schachter JB, Cosden M, Pearson M, Hess F, Selnick H, Salinas C, Li W, Duffy J, ... ... Vocadlo D, et al. O2-13-04: Early Clinical Results and Preclinical Validation of the O-Glcnacase (OGA) Inhibitor Mk-8719 as a Novel Therapeutic for the Treatment of Tauopathies Alzheimer's & Dementia. 12: P261-P261. DOI: 10.1016/J.Jalz.2016.06.469 |
0.439 |
|
| 2016 |
Sandhu P, Lee J, Ballard J, Walker B, Ellis J, Marcus J, Toolan D, Dreyer D, McAvoy T, Duffy J, Michener M, Valiathan C, Trainor N, Savage M, McEachern E, ... Vocadlo D, et al. P4-036: Pharmacokinetics and Pharmacodynamics to Support Clinical Studies of MK-8719: an O-Glcnacase Inhibitor for Progressive Supranuclear Palsy Alzheimer's & Dementia. 12: P1028-P1028. DOI: 10.1016/J.Jalz.2016.06.2125 |
0.396 |
|
| 2015 |
Bergeron-Brlek M, Goodwin-Tindall J, Cekic N, Roth C, Zandberg WF, Shan X, Varghese V, Chan S, Davies GJ, Vocadlo DJ, Britton R. A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors. Angewandte Chemie (International Ed. in English). PMID 26545827 DOI: 10.1002/Anie.201507985 |
0.755 |
|
| 2015 |
Gregg KJ, Suits MD, Deng L, Vocadlo DJ, Boraston AB. Structural analysis of a family 101 glycoside hydrolase in complex with carbohydrates reveals insights into its mechanism. The Journal of Biological Chemistry. PMID 26304114 DOI: 10.1074/Jbc.M115.680470 |
0.45 |
|
| 2015 |
Zhu Y, Liu TW, Madden Z, Yuzwa SA, Murray K, Cecioni S, Zachara N, Vocadlo DJ. Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter. Journal of Molecular Cell Biology. PMID 26031751 DOI: 10.1093/Jmcb/Mjv033 |
0.762 |
|
| 2015 |
Zhu Y, Liu TW, Cecioni S, Eskandari R, Zandberg WF, Vocadlo DJ. O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains. Nature Chemical Biology. 11: 319-25. PMID 25774941 DOI: 10.1038/Nchembio.1774 |
0.811 |
|
| 2015 |
Kolappan S, Shen DL, Mosi R, Sun J, McEachern EJ, Vocadlo DJ, Craig L. Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallographica. Section D, Biological Crystallography. 71: 185-95. PMID 25664730 DOI: 10.1107/S1399004714024791 |
0.379 |
|
| 2015 |
Sodi VL, Khaku S, Krutilina R, Schwab LP, Vocadlo DJ, Seagroves TN, Reginato MJ. mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer. Molecular Cancer Research : McR. 13: 923-33. PMID 25636967 DOI: 10.1158/1541-7786.Mcr-14-0536 |
0.469 |
|
| 2015 |
Yadav AK, Shen DL, Shan X, He X, Kermode AR, Vocadlo DJ. Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity. Journal of the American Chemical Society. 137: 1181-9. PMID 25562638 DOI: 10.1021/Ja5106738 |
0.366 |
|
| 2015 |
Vadlamani G, Thomas MD, Patel TR, Donald LJ, Reeve TM, Stetefeld J, Standing KG, Vocadlo DJ, Mark BL. The β-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide. The Journal of Biological Chemistry. 290: 2630-43. PMID 25480792 DOI: 10.2210/Pdb4Wkm/Pdb |
0.337 |
|
| 2014 |
Chakladar S, Wang Y, Clark T, Cheng L, Ko S, Vocadlo DJ, Bennet AJ. A mechanism-based inactivator of glycoside hydrolases involving formation of a transient non-classical carbocation. Nature Communications. 5: 5590. PMID 25475952 DOI: 10.1038/Ncomms6590 |
0.407 |
|
| 2014 |
Yuzwa SA, Shan X, Jones BA, Zhao G, Woodward ML, Li X, Zhu Y, McEachern EJ, Silverman MA, Watson NV, Gong CX, Vocadlo DJ. Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice. Molecular Neurodegeneration. 9: 42. PMID 25344697 DOI: 10.1186/1750-1326-9-42 |
0.416 |
|
| 2014 |
Zhu Y, Shan X, Yuzwa SA, Vocadlo DJ. The emerging link between O-GlcNAc and Alzheimer disease. The Journal of Biological Chemistry. 289: 34472-81. PMID 25336656 DOI: 10.1074/Jbc.R114.601351 |
0.409 |
|
| 2014 |
Lira-Navarrete E, Iglesias-Fernández J, Zandberg WF, Compañón I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo DJ, Rovira C, Hurtado-Guerrero R. Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2. Angewandte Chemie (International Ed. in English). 53: 8206-10. PMID 24954443 DOI: 10.1002/Anie.201402781 |
0.721 |
|
| 2014 |
Ferrer CM, Lynch TP, Sodi VL, Falcone JN, Schwab LP, Peacock DL, Vocadlo DJ, Seagroves TN, Reginato MJ. O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway. Molecular Cell. 54: 820-31. PMID 24857547 DOI: 10.1016/J.Molcel.2014.04.026 |
0.439 |
|
| 2014 |
Yuzwa SA, Vocadlo DJ. O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond. Chemical Society Reviews. 43: 6839-58. PMID 24759912 DOI: 10.1039/C4Cs00038B |
0.438 |
|
| 2014 |
Yuzwa SA, Cheung AH, Okon M, McIntosh LP, Vocadlo DJ. O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers. Journal of Molecular Biology. 426: 1736-52. PMID 24444746 DOI: 10.1016/J.Jmb.2014.01.004 |
0.43 |
|
| 2014 |
Bacik JP, Tavassoli M, Patel TR, McKenna SA, Vocadlo DJ, Khajehpour M, Mark BL. Conformational itinerary of Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase during its catalytic cycle. The Journal of Biological Chemistry. 289: 4504-14. PMID 24362022 DOI: 10.1074/Jbc.M113.521633 |
0.376 |
|
| 2014 |
Wang S, Shen DL, Lafont D, Vercoutter-Edouart AS, Mortuaire M, Shi Y, Maniti O, Girard-Egrot A, Lefebvre T, Pinto BM, Vocadlo D, Vidal S. Design of glycosyltransferase inhibitors targeting human O-GlcNAc transferase (OGT) Medchemcomm. 5: 1172-1178. DOI: 10.1039/C4Md00063C |
0.676 |
|
| 2013 |
Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science (New York, N.Y.). 342: 1235-9. PMID 24311690 DOI: 10.1126/Science.1243990 |
0.755 |
|
| 2013 |
Mondon M, Hur S, Vadlamani G, Rodrigues P, Tsybina P, Oliver A, Mark BL, Vocadlo DJ, Blériot Y. Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams. Chemical Communications (Cambridge, England). 49: 10983-5. PMID 24136176 DOI: 10.1039/C3Cc46646A |
0.306 |
|
| 2013 |
Pluvinage B, Stubbs KA, Hattie M, Vocadlo DJ, Boraston AB. Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase, StrH. Organic & Biomolecular Chemistry. 11: 7907-15. PMID 24132305 DOI: 10.1039/C3Ob41579A |
0.431 |
|
| 2013 |
Stubbs KA, Bacik JP, Perley-Robertson GE, Whitworth GE, Gloster TM, Vocadlo DJ, Mark BL. The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams. Chembiochem : a European Journal of Chemical Biology. 14: 1973-81. PMID 24009110 DOI: 10.1002/Cbic.201300395 |
0.385 |
|
| 2013 |
Cecioni S, Vocadlo DJ. Tools for probing and perturbing O-GlcNAc in cells and in vivo. Current Opinion in Chemical Biology. 17: 719-28. PMID 23906602 DOI: 10.1016/J.Cbpa.2013.06.030 |
0.773 |
|
| 2013 |
He X, Pierce O, Haselhorst T, von Itzstein M, Kolarich D, Packer NH, Gloster TM, Vocadlo DJ, Qian Y, Brooks D, Kermode AR. Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds. Plant Biotechnology Journal. 11: 1034-43. PMID 23898885 DOI: 10.1111/Pbi.12096 |
0.425 |
|
| 2013 |
Deng L, Tsybina P, Gregg KJ, Mosi R, Zandberg WF, Boraston AB, Vocadlo DJ. Synthesis of 4-methylumbelliferyl α-d-mannopyranosyl-(1→6)-β-d-mannopyranoside and development of a coupled fluorescent assay for GH125 exo-α-1,6-mannosidases. Bioorganic & Medicinal Chemistry. 21: 4839-45. PMID 23816041 DOI: 10.1016/J.Bmc.2013.05.062 |
0.71 |
|
| 2013 |
Ma Z, Vocadlo DJ, Vosseller K. Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells. The Journal of Biological Chemistry. 288: 15121-30. PMID 23592772 DOI: 10.1074/Jbc.M113.470047 |
0.472 |
|
| 2012 |
Bacik JP, Whitworth GE, Stubbs KA, Vocadlo DJ, Mark BL. Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion. Chemistry & Biology. 19: 1471-82. PMID 23177201 DOI: 10.1016/J.Chembiol.2012.09.016 |
0.428 |
|
| 2012 |
Vocadlo DJ, Withers SG. How to make a difference: mechanisms of protein and nucleic acid modifying enzymes. Current Opinion in Chemical Biology. 16: 461-4. PMID 23168221 DOI: 10.1016/J.Cbpa.2012.10.033 |
0.513 |
|
| 2012 |
Vocadlo DJ. O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation. Current Opinion in Chemical Biology. 16: 488-97. PMID 23146438 DOI: 10.1016/J.Cbpa.2012.10.021 |
0.545 |
|
| 2012 |
Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nature Chemical Biology. 8: 966-8. PMID 23103939 DOI: 10.1038/Nchembio.1109 |
0.767 |
|
| 2012 |
Zandberg WF, Kumarasamy J, Pinto BM, Vocadlo DJ. Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion. The Journal of Biological Chemistry. 287: 40021-30. PMID 23019334 DOI: 10.1074/Jbc.M112.403568 |
0.67 |
|
| 2012 |
He X, Haselhorst T, von Itzstein M, Kolarich D, Packer NH, Gloster TM, Vocadlo DJ, Clarke LA, Qian Y, Kermode AR. Production of α-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease. Nature Communications. 3: 1062. PMID 22990858 DOI: 10.1038/Ncomms2070 |
0.368 |
|
| 2012 |
Gloster TM, Vocadlo DJ. Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology. Nature Chemical Biology. 8: 683-94. PMID 22810773 DOI: 10.1038/Nchembio.1029 |
0.42 |
|
| 2012 |
Bergfeld AK, Pearce OM, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine. The Journal of Biological Chemistry. 287: 28898-916. PMID 22692203 DOI: 10.1074/Jbc.M112.363499 |
0.434 |
|
| 2012 |
Macauley MS, Chan J, Zandberg WF, He Y, Whitworth GE, Stubbs KA, Yuzwa SA, Bennet AJ, Varki A, Davies GJ, Vocadlo DJ. Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase. The Journal of Biological Chemistry. 287: 28882-97. PMID 22692202 DOI: 10.1074/Jbc.M112.363721 |
0.779 |
|
| 2012 |
Yu Y, Zhang L, Li X, Run X, Liang Z, Li Y, Liu Y, Lee MH, Grundke-Iqbal I, Iqbal K, Vocadlo DJ, Liu F, Gong CX. Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. Plos One. 7: e35277. PMID 22536363 DOI: 10.1371/Journal.Pone.0035277 |
0.383 |
|
| 2012 |
Shan X, Vocadlo DJ, Krieger C. Reduced protein O-glycosylation in the nervous system of the mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis. Neuroscience Letters. 516: 296-301. PMID 22521585 DOI: 10.1016/J.Neulet.2012.04.018 |
0.435 |
|
| 2012 |
Hehemann JH, Smyth L, Yadav A, Vocadlo DJ, Boraston AB. Analysis of keystone enzyme in Agar hydrolysis provides insight into the degradation (of a polysaccharide from) red seaweeds. The Journal of Biological Chemistry. 287: 13985-95. PMID 22393053 DOI: 10.1074/Jbc.M112.345645 |
0.404 |
|
| 2012 |
Yuzwa SA, Shan X, Macauley MS, Clark T, Skorobogatko Y, Vosseller K, Vocadlo DJ. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nature Chemical Biology. 8: 393-9. PMID 22366723 DOI: 10.1038/Nchembio.797 |
0.435 |
|
| 2012 |
Shen DL, Gloster TM, Yuzwa SA, Vocadlo DJ. Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates. The Journal of Biological Chemistry. 287: 15395-408. PMID 22311971 DOI: 10.1074/Jbc.M111.310664 |
0.524 |
|
| 2012 |
Macauley, Chan J, Zandberg WF, He Y, Whitworth GE, Stubbs KA, Yuzwa SA, Bennet AJ, Varki A, Davies GJ, Vocadlo DJ. Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: Intracellular Beta-O-Linked N-Glycolylglucosamine (Glcngc), Udp-Glcngc, and the Biochemical and Structural Rationale for the Substrate Tolerance of Beta-O-Linked Beta-N-Acetylglucosaminidase. Journal of Biological Chemistry. 287: 28882. DOI: 10.2210/Pdb4Ais/Pdb |
0.413 |
|
| 2011 |
Mark BL, Vocadlo DJ, Oliver A. Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway. Future Microbiology. 6: 1415-27. PMID 22122439 DOI: 10.2217/Fmb.11.128 |
0.304 |
|
| 2011 |
Pluvinage B, Higgins MA, Abbott DW, Robb C, Dalia AB, Deng L, Weiser JN, Parsons TB, Fairbanks AJ, Vocadlo DJ, Boraston AB. Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis. Structure (London, England : 1993). 19: 1603-14. PMID 22078560 DOI: 10.1016/J.Str.2011.08.011 |
0.366 |
|
| 2011 |
Lee SS, Greig IR, Vocadlo DJ, McCarter JD, Patrick BO, Withers SG. Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides. Journal of the American Chemical Society. 133: 15826-9. PMID 21910446 DOI: 10.1021/Ja204829R |
0.468 |
|
| 2011 |
Lammerts van Bueren A, Ficko-Blean E, Pluvinage B, Hehemann JH, Higgins MA, Deng L, Ogunniyi AD, Stroeher UH, El Warry N, Burke RD, Czjzek M, Paton JC, Vocadlo DJ, Boraston AB. The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure (London, England : 1993). 19: 640-51. PMID 21565699 DOI: 10.1016/J.Str.2011.03.001 |
0.376 |
|
| 2011 |
Gregg KJ, Zandberg WF, Hehemann JH, Whitworth GE, Deng L, Vocadlo DJ, Boraston AB. Analysis of a new family of widely distributed metal-independent alpha-mannosidases provides unique insight into the processing of N-linked glycans. The Journal of Biological Chemistry. 286: 15586-96. PMID 21388958 DOI: 10.1074/Jbc.M111.223172 |
0.704 |
|
| 2011 |
Bacik JP, Whitworth GE, Stubbs KA, Yadav AK, Martin DR, Bailey-Elkin BA, Vocadlo DJ, Mark BL. Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase. The Journal of Biological Chemistry. 286: 12283-91. PMID 21288904 DOI: 10.1074/Jbc.M110.198317 |
0.421 |
|
| 2011 |
Mayer A, Gloster TM, Chou WK, Vocadlo DJ, Tanner ME. 6''-Azido-6''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate. Bioorganic & Medicinal Chemistry Letters. 21: 1199-201. PMID 21273069 DOI: 10.1016/J.Bmcl.2010.12.090 |
0.386 |
|
| 2011 |
Gloster TM, Zandberg WF, Heinonen JE, Shen DL, Deng L, Vocadlo DJ. Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells. Nature Chemical Biology. 7: 174-81. PMID 21258330 DOI: 10.1038/Nchembio.520 |
0.771 |
|
| 2011 |
Yuzwa SA, Yadav AK, Skorobogatko Y, Clark T, Vosseller K, Vocadlo DJ. Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody. Amino Acids. 40: 857-68. PMID 20706749 DOI: 10.1007/S00726-010-0705-1 |
0.434 |
|
| 2010 |
Macauley MS, Shan X, Yuzwa SA, Gloster TM, Vocadlo DJ. Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. Chemistry & Biology. 17: 949-58. PMID 20851344 DOI: 10.1016/J.Chembiol.2010.07.005 |
0.404 |
|
| 2010 |
Macauley MS, He Y, Gloster TM, Stubbs KA, Davies GJ, Vocadlo DJ. Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chemistry & Biology. 17: 937-48. PMID 20851343 DOI: 10.1016/j.chembiol.2010.07.006 |
0.398 |
|
| 2010 |
Balcewich MD, Reeve TM, Orlikow EA, Donald LJ, Vocadlo DJ, Mark BL. Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase. Journal of Molecular Biology. 400: 998-1010. PMID 20594961 DOI: 10.1016/J.Jmb.2010.05.040 |
0.322 |
|
| 2010 |
Parsons TB, Patel MK, Boraston AB, Vocadlo DJ, Fairbanks AJ. Streptococcus pneumoniae endohexosaminidase D; feasibility of using N-glycan oxazoline donors for synthetic glycosylation of a GlcNAc-asparagine acceptor. Organic & Biomolecular Chemistry. 8: 1861-9. PMID 20449490 DOI: 10.1039/B926078A |
0.39 |
|
| 2010 |
Gloster TM, Vocadlo DJ. Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes. Current Signal Transduction Therapy. 5: 74-91. PMID 20396401 DOI: 10.2174/157436210790226537 |
0.553 |
|
| 2010 |
He Y, Macauley MS, Stubbs KA, Vocadlo DJ, Davies GJ. Visualizing the reaction coordinate of an O-GlcNAc hydrolase. Journal of the American Chemical Society. 132: 1807-9. PMID 20067256 DOI: 10.1021/Ja9086769 |
0.5 |
|
| 2010 |
Whitworth GE, Zandberg WF, Clark T, Vocadlo DJ. Mammalian Notch is modified by D-Xyl-alpha1-3-D-Xyl-alpha1-3-D-Glc-beta1-O-Ser: implementation of a method to study O-glucosylation. Glycobiology. 20: 287-99. PMID 19907056 DOI: 10.1093/Glycob/Cwp173 |
0.716 |
|
| 2010 |
Macauley MS, Vocadlo DJ. Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase. Biochimica Et Biophysica Acta. 1800: 107-21. PMID 19664691 DOI: 10.1016/J.Bbagen.2009.07.028 |
0.488 |
|
| 2010 |
KNAPP S, KIRK BA, VOCADLO D, WITHERS SG. ChemInform Abstract: An Allosamizoline/Glucosamine Hybrid NAGase Inhibitor. Cheminform. 28: no-no. DOI: 10.1002/chin.199742250 |
0.378 |
|
| 2009 |
Yuzwa SA, Vocadlo DJ. O-GlcNAc modification and the tauopathies: insights from chemical biology. Current Alzheimer Research. 6: 451-4. PMID 19874270 DOI: 10.2174/156720509789207967 |
0.379 |
|
| 2009 |
Greig IR, Macauley MS, Williams IH, Vocadlo DJ. Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships. Journal of the American Chemical Society. 131: 13415-22. PMID 19715310 DOI: 10.1021/Ja904506U |
0.528 |
|
| 2009 |
Sinclair DA, Syrzycka M, Macauley MS, Rastgardani T, Komljenovic I, Vocadlo DJ, Brock HW, Honda BM. Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proceedings of the National Academy of Sciences of the United States of America. 106: 13427-32. PMID 19666537 DOI: 10.1073/Pnas.0904638106 |
0.48 |
|
| 2009 |
Higgins MA, Whitworth GE, El Warry N, Randriantsoa M, Samain E, Burke RD, Vocadlo DJ, Boraston AB. Differential recognition and hydrolysis of host carbohydrate antigens by Streptococcus pneumoniae family 98 glycoside hydrolases. The Journal of Biological Chemistry. 284: 26161-73. PMID 19608744 DOI: 10.1074/Jbc.M109.024067 |
0.345 |
|
| 2009 |
Balcewich MD, Stubbs KA, He Y, James TW, Davies GJ, Vocadlo DJ, Mark BL. Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ. Protein Science : a Publication of the Protein Society. 18: 1541-51. PMID 19499593 DOI: 10.1002/Pro.137 |
0.476 |
|
| 2009 |
Macauley MS, Vocadlo DJ. Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase. Carbohydrate Research. 344: 1079-84. PMID 19423084 DOI: 10.1016/J.Carres.2009.04.017 |
0.524 |
|
| 2009 |
Marcelo F, He Y, Yuzwa SA, Nieto L, Jiménez-Barbero J, Sollogoub M, Vocadlo DJ, Davies GD, Blériot Y. Molecular basis for inhibition of GH84 glycoside hydrolases by substituted azepanes: conformational flexibility enables probing of substrate distortion. Journal of the American Chemical Society. 131: 5390-2. PMID 19331390 DOI: 10.1021/Ja809776R |
0.535 |
|
| 2009 |
Abbott DW, Macauley MS, Vocadlo DJ, Boraston AB. Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. The Journal of Biological Chemistry. 284: 11676-89. PMID 19181667 DOI: 10.1074/Jbc.M809663200 |
0.433 |
|
| 2009 |
Stubbs KA, Macauley MS, Vocadlo DJ. A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. Angewandte Chemie (International Ed. in English). 48: 1300-3. PMID 19130519 DOI: 10.1002/Anie.200804583 |
0.41 |
|
| 2009 |
Francisco H, Kollins K, Varghis N, Vocadlo D, Vosseller K, Gallo G. O-GLcNAc post-translational modifications regulate the entry of neurons into an axon branching program. Developmental Neurobiology. 69: 162-73. PMID 19086029 DOI: 10.1002/Dneu.20695 |
0.416 |
|
| 2009 |
Tallent MK, Varghis N, Skorobogatko Y, Hernandez-Cuebas L, Whelan K, Vocadlo DJ, Vosseller K. In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. The Journal of Biological Chemistry. 284: 174-81. PMID 19004831 DOI: 10.1074/Jbc.M807431200 |
0.432 |
|
| 2009 |
Stubbs KA, Vocadlo DJ. Affinity-based proteomics probes; Tools for studying carbohydrate- processing enzymes Australian Journal of Chemistry. 62: 521-527. DOI: 10.1071/Ch09140 |
0.402 |
|
| 2009 |
Davies GJ, Withers SG, Vocadlo DJ. The chitopentaose complex of a mutant en egg-white lysozyme displays no distortion of the -1 sugar away from a 4C1 chair conformation Australian Journal of Chemistry. 62: 528-532. DOI: 10.1071/Ch09038 |
0.458 |
|
| 2009 |
Vosseller K, Skorobogatko Y, Bryfogle JA, LaFerla FM, Vocadlo DJ, Tallent M. P4-228: O-GlcNAc regulation of hippocampal synaptic plasticity in wild type and 3xTg-AD mice Alzheimer's & Dementia. 5: P497-P497. DOI: 10.1016/J.Jalz.2009.04.694 |
0.311 |
|
| 2008 |
Macauley MS, Bubb AK, Martinez-Fleites C, Davies GJ, Vocadlo DJ. Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. The Journal of Biological Chemistry. 283: 34687-95. PMID 18842583 DOI: 10.1074/Jbc.M804525200 |
0.461 |
|
| 2008 |
Scaffidi A, Stubbs KA, Vocadlo DJ, Stick RV. The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc. Carbohydrate Research. 343: 2744-53. PMID 18804755 DOI: 10.1016/J.Carres.2008.08.012 |
0.403 |
|
| 2008 |
Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nature Chemical Biology. 4: 483-90. PMID 18587388 DOI: 10.1038/Nchembio.96 |
0.407 |
|
| 2008 |
Vocadlo DJ, Davies GJ. Mechanistic insights into glycosidase chemistry. Current Opinion in Chemical Biology. 12: 539-55. PMID 18558099 DOI: 10.1016/J.Cbpa.2008.05.010 |
0.373 |
|
| 2008 |
Martinez-Fleites C, Macauley MS, He Y, Shen DL, Vocadlo DJ, Davies GJ. Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation. Nature Structural & Molecular Biology. 15: 764-5. PMID 18536723 DOI: 10.1038/Nsmb.1443 |
0.534 |
|
| 2008 |
Ficko-Blean E, Stubbs KA, Nemirovsky O, Vocadlo DJ, Boraston AB. Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB. Proceedings of the National Academy of Sciences of the United States of America. 105: 6560-5. PMID 18443291 DOI: 10.1073/Pnas.0711491105 |
0.423 |
|
| 2008 |
Stubbs KA, Scaffidi A, Debowski AW, Mark BL, Stick RV, Vocadlo DJ. Synthesis and use of mechanism-based protein-profiling probes for retaining beta-D-glucosaminidases facilitate identification of Pseudomonas aeruginosa NagZ. Journal of the American Chemical Society. 130: 327-35. PMID 18067297 DOI: 10.1021/Ja0763605 |
0.383 |
|
| 2008 |
Vocadlo DJ, Withers SG. Glycosidase-catalysed oligosaccharide synthesis Carbohydrates in Chemistry and Biology. 2: 723-844. DOI: 10.1002/9783527618255.Ch29 |
0.453 |
|
| 2007 |
Scaffidi A, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Vocadlo DJ, Stick RV. A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases. Organic & Biomolecular Chemistry. 5: 3013-9. PMID 17728868 DOI: 10.1039/B709681J |
0.374 |
|
| 2007 |
Stubbs KA, Balcewich M, Mark BL, Vocadlo DJ. Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. The Journal of Biological Chemistry. 282: 21382-91. PMID 17439950 DOI: 10.1074/Jbc.M700084200 |
0.348 |
|
| 2007 |
Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ. Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. Journal of the American Chemical Society. 129: 635-44. PMID 17227027 DOI: 10.1021/Ja065697O |
0.449 |
|
| 2006 |
Stubbs KA, Vocadlo DJ. Functional proteomic profiling of glycan-processing enzymes. Methods in Enzymology. 415: 253-68. PMID 17116479 DOI: 10.1016/S0076-6879(06)15016-8 |
0.417 |
|
| 2006 |
Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A. Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor. Chemical Communications (Cambridge, England). 4372-4. PMID 17057847 DOI: 10.1039/B612154C |
0.48 |
|
| 2006 |
Sheldon WL, Macauley MS, Taylor EJ, Robinson CE, Charnock SJ, Davies GJ, Vocadlo DJ, Black GW. Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase. The Biochemical Journal. 399: 241-7. PMID 16822234 DOI: 10.1042/Bj20060307 |
0.441 |
|
| 2006 |
Mayer C, Vocadlo DJ, Mah M, Rupitz K, Stoll D, Warren RA, Withers SG. Characterization of a beta-N-acetylhexosaminidase and a beta-N-acetylglucosaminidase/beta-glucosidase from Cellulomonas fimi. The Febs Journal. 273: 2929-41. PMID 16762038 DOI: 10.1111/J.1742-4658.2006.05308.X |
0.484 |
|
| 2006 |
Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ. Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nature Structural & Molecular Biology. 13: 365-71. PMID 16565725 DOI: 10.1038/Nsmb1079 |
0.549 |
|
| 2006 |
CetinbaÅŸ N, Macauley MS, Stubbs KA, Drapala R, Vocadlo DJ. Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants. Biochemistry. 45: 3835-44. PMID 16533067 DOI: 10.1021/Bi052370B |
0.523 |
|
| 2006 |
Stubbs KA, Zhang N, Vocadlo DJ. A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase. Organic & Biomolecular Chemistry. 4: 839-45. PMID 16493467 DOI: 10.1039/B516273D |
0.515 |
|
| 2006 |
Stubbs KA, Macauley MS, Vocadlo DJ. A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides. Carbohydrate Research. 341: 1764-9. PMID 16472788 DOI: 10.1016/J.Carres.2005.12.009 |
0.402 |
|
| 2006 |
Mougous JD, Lee DH, Hubbard SC, Schelle MW, Vocadlo DJ, Berger JM, Bertozzi CR. Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Molecular Cell. 21: 109-22. PMID 16387658 DOI: 10.1016/J.Molcel.2005.10.034 |
0.33 |
|
| 2005 |
Macauley MS, Stubbs KA, Vocadlo DJ. O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis. Journal of the American Chemical Society. 127: 17202-3. PMID 16332065 DOI: 10.1021/Ja0567687 |
0.493 |
|
| 2005 |
Vocadlo DJ, Withers SG. Detailed comparative analysis of the catalytic mechanisms of beta-N-acetylglucosaminidases from families 3 and 20 of glycoside hydrolases. Biochemistry. 44: 12809-18. PMID 16171396 DOI: 10.1021/Bi051121K |
0.556 |
|
| 2005 |
Macauley MS, Whitworth GE, Debowski AW, Chin D, Vocadlo DJ. O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors. The Journal of Biological Chemistry. 280: 25313-22. PMID 15795231 DOI: 10.1074/Jbc.M413819200 |
0.538 |
|
| 2005 |
Vocadlo DJ, Withers SG. The chemical synthesis of 2-deoxy-2-fluorodisaccharide probes of the hen egg white lysozyme mechanism. Carbohydrate Research. 340: 379-88. PMID 15680592 DOI: 10.1016/J.Carres.2004.12.015 |
0.507 |
|
| 2004 |
Yang JK, Yoon HJ, Ahn HJ, Lee BI, Pedelacq JD, Liong EC, Berendzen J, Laivenieks M, Vieille C, Zeikus GJ, Vocadlo DJ, Withers SG, Suh SW. Crystal structure of beta-D-xylosidase from Thermoanaerobacterium saccharolyticum, a family 39 glycoside hydrolase. Journal of Molecular Biology. 335: 155-65. PMID 14659747 DOI: 10.1016/J.Jmb.2003.10.026 |
0.501 |
|
| 2003 |
Vocadlo DJ, Hang HC, Kim EJ, Hanover JA, Bertozzi CR. A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 9116-21. PMID 12874386 DOI: 10.1073/Pnas.1632821100 |
0.518 |
|
| 2002 |
Williams SJ, Mark BL, Vocadlo DJ, James MN, Withers SG. Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. The Journal of Biological Chemistry. 277: 40055-65. PMID 12171933 DOI: 10.1074/Jbc.M206481200 |
0.661 |
|
| 2002 |
Vocadlo DJ, Wicki J, Rupitz K, Withers SG. A case for reverse protonation: identification of Glu160 as an acid/base catalyst in Thermoanaerobacterium saccharolyticum beta-xylosidase and detailed kinetic analysis of a site-directed mutant. Biochemistry. 41: 9736-46. PMID 12146939 DOI: 10.1021/Bi020078N |
0.556 |
|
| 2002 |
Vocadlo DJ, Wicki J, Rupitz K, Withers SG. Mechanism of Thermoanaerobacterium saccharolyticum beta-xylosidase: kinetic studies. Biochemistry. 41: 9727-35. PMID 12146938 DOI: 10.1021/Bi020077V |
0.501 |
|
| 2002 |
Mark BL, Vocadlo DJ, Zhao D, Knapp S, Withers SG, James MNG. Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 β-hexosaminidase inhibitor Acta Crystallographica Section a Foundations of Crystallography. 58: c106-c106. DOI: 10.1107/S0108767302089274 |
0.493 |
|
| 2001 |
Mark BL, Vocadlo DJ, Zhao D, Knapp S, Withers SG, James MN. Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor. The Journal of Biological Chemistry. 276: 42131-7. PMID 11522797 DOI: 10.1074/Jbc.M107154200 |
0.553 |
|
| 2001 |
Vocadlo DJ, Davies GJ, Laine R, Withers SG. Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate. Nature. 412: 835-8. PMID 11518970 DOI: 10.1038/35090602 |
0.544 |
|
| 2001 |
Hou Y, Vocadlo DJ, Leung A, Withers SG, Mahuran D. Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase B. Biochemistry. 40: 2201-9. PMID 11329289 DOI: 10.1021/Bi002018S |
0.51 |
|
| 2001 |
Mark BL, Vocadlo DJ, Knapp S, Triggs-Raine BL, Withers SG, James MN. Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase. The Journal of Biological Chemistry. 276: 10330-7. PMID 11124970 DOI: 10.1074/Jbc.M011067200 |
0.524 |
|
| 2001 |
Vocadlo DJ, Withers SG. ChemInform Abstract: Glycosidase-Catalyzed Oligosaccharide Synthesis Cheminform. 32: no-no. DOI: 10.1002/chin.200112257 |
0.389 |
|
| 2000 |
Vocadlo DJ, Withers SG. Identification of active site residues in glycosidases by use of tandem mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 146: 203-22. PMID 10948504 DOI: 10.1385/1-59259-045-4:203 |
0.455 |
|
| 2000 |
Hou Y, Vocadlo D, Withers S, Mahuran D. Role of beta Arg211 in the active site of human beta-hexosaminidase B. Biochemistry. 39: 6219-27. PMID 10821697 DOI: 10.1021/Bi992464J |
0.541 |
|
| 2000 |
Vocadlo DJ, Mayer C, He S, Withers SG. Mechanism of action and identification of Asp242 as the catalytic nucleophile of Vibrio furnisii N-acetyl-beta-D-glucosaminidase using 2-acetamido-2-deoxy-5-fluoro-alpha-L-idopyranosyl fluoride. Biochemistry. 39: 117-26. PMID 10625486 DOI: 10.1021/Bi991958D |
0.537 |
|
| 1998 |
Vocadlo DJ, MacKenzie LF, He S, Zeikus GJ, Withers SG. Identification of glu-277 as the catalytic nucleophile of Thermoanaerobacterium saccharolyticum beta-xylosidase using electrospray MS. The Biochemical Journal. 335: 449-55. PMID 9761746 DOI: 10.1042/Bj3350449 |
0.509 |
|
| 1997 |
Knapp S, Kirk B, Vocadlo D, Withers S. An Allosamizoline/Glucosamine Hybrid NAGase Inhibitor Synlett. 1997: 435-436. DOI: 10.1055/S-1997-6124 |
0.451 |
|
| 1996 |
Knapp S, Vocadlo D, Gao Z, Kirk B, Lou J, Withers SG. NAG-thiazoline, AnN-Acetyl-β-hexosaminidase Inhibitor That Implicates Acetamido Participation Journal of the American Chemical Society. 118: 6804-6805. DOI: 10.1021/Ja960826U |
0.462 |
|
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