Nancy J. Zeleznik-Le - Publications

Molecular Biology Loyola University Chicago, Chicago, IL, United States 
Molecular Biology

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Mian YA, Zeleznik-Le NJ. The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1. Leukemia Research. 46: 51-60. PMID 27123834 DOI: 10.1016/j.leukres.2016.04.006  0.88
2016 Achille NJ, Othus M, Phelan K, Zhang S, Cooper K, Godwin JE, Appelbaum FR, Radich JP, Erba HP, Nand S, Zeleznik-Le NJ. Association between early promoter-specific DNA methylation changes and outcome in older acute myeloid leukemia patients. Leukemia Research. PMID 26818573 DOI: 10.1016/j.leukres.2016.01.004  0.88
2015 Zeleznik-Le NJ. Introduction to progress and promise of epigenetics for diagnosis and therapy in cancer. Cancer Genetics. 208: 165-6. PMID 25981828 DOI: 10.1016/j.cancergen.2015.04.003  0.88
2015 Kuntimaddi A, Achille NJ, Thorpe J, Lokken AA, Singh R, Hemenway CS, Adli M, Zeleznik-Le NJ, Bushweller JH. Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential. Cell Reports. 11: 808-20. PMID 25921540 DOI: 10.1016/j.celrep.2015.04.004  0.88
2015 You D, Xin J, Volk A, Wei W, Schmidt R, Scurti G, Nand S, Breuer EK, Kuo PC, Breslin P, Kini AR, Nishimura MI, Zeleznik-Le NJ, Zhang J. FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN-null T-ALL cells. Cell Reports. 10: 2055-68. PMID 25801032 DOI: 10.1016/j.celrep.2015.02.056  0.88
2015 Brockway S, Zeleznik-Le NJ. WEE1 is a validated target of the microRNA miR-17-92 cluster in leukemia. Cancer Genetics. 208: 279-87. PMID 25732734 DOI: 10.1016/j.cancergen.2015.01.001  0.88
2015 Shang N, Arteaga M, Zaidi A, Stauffer J, Cotler SJ, Zeleznik-Le NJ, Zhang J, Qiu W. FAK is required for c-Met/β-catenin-driven hepatocarcinogenesis. Hepatology (Baltimore, Md.). 61: 214-26. PMID 25163657 DOI: 10.1002/hep.27402  0.88
2014 Lokken AA, Achille NJ, Chang MJ, Lin JJ, Kuntimaddi A, Leach BI, Malik B, Nesbit JB, Zhang S, Bushweller JH, Zeleznik-Le NJ, Hemenway CS. Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4. Leukemia Research. 38: 1309-15. PMID 25282333 DOI: 10.1016/j.leukres.2014.08.010  0.88
2014 Zeleznik-Le NJ, Testa JR. In memoriam: Janet D. Rowley, MD (April 5, 1925-December 17, 2013). Cancer Genetics. 207: 46-7. PMID 24795993  0.88
2014 Velu CS, Chaubey A, Phelan JD, Horman SR, Wunderlich M, Guzman ML, Jegga AG, Zeleznik-Le NJ, Chen J, Mulloy JC, Cancelas JA, Jordan CT, Aronow BJ, Marcucci G, Bhat B, et al. Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. The Journal of Clinical Investigation. 124: 222-36. PMID 24334453 DOI: 10.1172/JCI66005  0.88
2013 Risner LE, Kuntimaddi A, Lokken AA, Achille NJ, Birch NW, Schoenfelt K, Bushweller JH, Zeleznik-Le NJ. Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia. The Journal of Biological Chemistry. 288: 29901-10. PMID 23990460 DOI: 10.1074/jbc.M113.474858  0.88
2013 Zhang J, Seet CS, Sun C, Li J, You D, Volk A, Breslin P, Li X, Wei W, Qian Z, Zeleznik-Le NJ, Zhang Z, Zhang J. p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia. Molecular Oncology. 7: 1069-82. PMID 23988911 DOI: 10.1016/j.molonc.2013.07.011  0.88
2012 Lokken AA, Zeleznik-Le NJ. Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML. Cancer Cell. 21: 451-3. PMID 22516254 DOI: 10.1016/j.ccr.2012.03.027  0.84
2012 Li Z, Huang H, Chen P, He M, Li Y, Arnovitz S, Jiang X, He C, Hyjek E, Zhang J, Zhang Z, Elkahloun A, Cao D, Shen C, Wunderlich M, ... ... Zeleznik-Le NJ, et al. miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nature Communications. 3: 688. PMID 22353710 DOI: 10.1038/ncomms1681  0.88
2011 Zook EC, Krishack PA, Zhang S, Zeleznik-Le NJ, Firulli AB, Witte PL, Le PT. Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells. Blood. 118: 5723-31. PMID 21908422 DOI: 10.1182/blood-2011-03-342097  0.88
2010 Chang MJ, Wu H, Achille NJ, Reisenauer MR, Chou CW, Zeleznik-Le NJ, Hemenway CS, Zhang W. Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. Cancer Research. 70: 10234-42. PMID 21159644 DOI: 10.1158/0008-5472.CAN-10-3294  0.88
2010 Birch NW, Zeleznik-Le NJ. Glycogen synthase kinase-3 and leukemia: restoring the balance. Cancer Cell. 17: 529-31. PMID 20541696 DOI: 10.1016/j.ccr.2010.05.017  0.88
2010 Mian YA, Zeleznik-Le NJ. MicroRNAs in leukemias: emerging diagnostic tools and therapeutic targets. Current Drug Targets. 11: 801-11. PMID 20370647 DOI: 10.2174/138945010791320872  0.88
2010 Mi S, Li Z, Chen P, He C, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, et al. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proceedings of the National Academy of Sciences of the United States of America. 107: 3710-5. PMID 20133587 DOI: 10.1073/pnas.0914900107  0.88
2010 Cierpicki T, Risner LE, Grembecka J, Lukasik SM, Popovic R, Omonkowska M, Shultis DD, Zeleznik-Le NJ, Bushweller JH. Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. Nature Structural & Molecular Biology. 17: 62-8. PMID 20010842 DOI: 10.1038/nsmb.1714  0.88
2009 Popovic R, Riesbeck LE, Velu CS, Chaubey A, Zhang J, Achille NJ, Erfurth FE, Eaton K, Lu J, Grimes HL, Chen J, Rowley JD, Zeleznik-Le NJ. Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization. Blood. 113: 3314-22. PMID 19188669 DOI: 10.1182/blood-2008-04-154310  0.88
2008 Chen J, Santillan DA, Koonce M, Wei W, Luo R, Thirman MJ, Zeleznik-Le NJ, Diaz MO. Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. Cancer Research. 68: 6199-207. PMID 18676843 DOI: 10.1158/0008-5472.CAN-07-6514  0.88
2008 Erfurth FE, Popovic R, Grembecka J, Cierpicki T, Theisler C, Xia ZB, Stuart T, Diaz MO, Bushweller JH, Zeleznik-Le NJ. MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proceedings of the National Academy of Sciences of the United States of America. 105: 7517-22. PMID 18483194 DOI: 10.1073/pnas.0800090105  0.88
2006 Santillan DA, Theisler CM, Ryan AS, Popovic R, Stuart T, Zhou MM, Alkan S, Zeleznik-Le NJ. Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype. Cancer Research. 66: 10032-9. PMID 17047066 DOI: 10.1158/0008-5472.CAN-06-2597  0.88
2005 Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ. The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. Proceedings of the National Academy of Sciences of the United States of America. 102: 14028-33. PMID 16169901 DOI: 10.1073/pnas.0506464102  0.88
2005 Popovic R, Zeleznik-Le NJ. MLL: how complex does it get? Journal of Cellular Biochemistry. 95: 234-42. PMID 15779005 DOI: 10.1002/jcb.20430  0.88
2005 Zeleznik-Le NJ. Leukemia RNAi: Harnessing the killer within Blood. 106: 3336-3337. DOI: 10.1182/blood-2005-08-3500  0.88
2004 Vazquez I, Lahortiga I, Agirre X, Larrayoz MJ, Vizmanos JL, Ardanaz MT, Zeleznik-Le NJ, Calasanz MJ, Odero MD. Cryptic ins(2;11) with clonal evolution showing amplification of 11q23-q25 either on hsr(11) or on dmin, in a patient with AML-M2 [4] Leukemia. 18: 2041-2044. PMID 15483676 DOI: 10.1038/sj.leu.2403535  0.88
2004 Mujtaba S, He Y, Zeng L, Yan S, Plotnikova O, Sachchidanand, Sanchez R, Zeleznik-Le NJ, Ronai Z, Zhou MM. Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Molecular Cell. 13: 251-63. PMID 14759370 DOI: 10.1016/S1097-2765(03)00528-8  0.88
2003 Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ. MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 100: 8342-7. PMID 12829790 DOI: 10.1073/pnas.1436338100  0.88
2003 Kuefer MU, Chinwalla V, Zeleznik-Le NJ, Behm FG, Naeve CW, Rakestraw KM, Mukatira ST, Raimondi SC, Morris SW. Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14). Oncogene. 22: 1418-24. PMID 12618768 DOI: 10.1038/sj.onc.1206272  0.88
2003 Chinwalla V, Chien A, Odero M, Neilly MB, Zeleznik-Le NJ, Rowley JD. A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15. Oncogene. 22: 1400-10. PMID 12618766 DOI: 10.1038/sj.onc.1206273  0.88
2002 Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, ... ... Zeleznik-Le NJ, et al. Mammalian septins nomenclature. Molecular Biology of the Cell. 13: 4111-3. PMID 12475938 DOI: 10.1091/mbc.E02-07-0438  0.88
2002 Odero MD, Vizmanos JL, Román JP, Lahortiga I, Panizo C, Calasanz MJ, Zeleznik-Le NJ, Rowley JD, Novo FJ. A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome. Genes, Chromosomes & Cancer. 35: 11-9. PMID 12203785 DOI: 10.1002/gcc.10090  0.88
2001 Whitman SP, Strout MP, Marcucci G, Freud AG, Culley LL, Zeleznik-Le NJ, Mrózek K, Theil KS, Kees UR, Bloomfield CD, Caligiuri MA. The partial nontandem duplication of the MLL (ALL1) gene is a novel rearrangement that generates three distinct fusion transcripts in B-cell acute lymphoblastic leukemia. Cancer Research. 61: 59-63. PMID 11196198  0.88
2000 Odero MD, Zeleznik-Le NJ, Chinwalla V, Rowley JD. Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation Genes Chromosomes and Cancer. 29: 333-338. PMID 11066077  0.88
2000 Strissel PL, Strick R, Tomek RJ, Roe BA, Rowley JD, Zeleznik-Le NJ. DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis Human Molecular Genetics. 9: 1671-1679. PMID 10861294  0.88
1999 Osaka M, Rowley JD, Zeleznik-Le NJ. MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25) Proceedings of the National Academy of Sciences of the United States of America. 96: 6428-6433. PMID 10339604 DOI: 10.1073/pnas.96.11.6428  0.88
1998 Atlas M, Head D, Behm F, Schmidt E, Zeleznik-Le NJ, Roe BA, Burian D, Domer PH. Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints Leukemia. 12: 1895-1902. PMID 9844920  0.88
1998 Strissel PL, Strick R, Rowley JD, Zeleznik-Le NJ. An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region Blood. 92: 3793-3803. PMID 9808573  0.88
1997 Super HG, Strissel PL, Sobulo OM, Burian D, Reshmi SC, Roe B, Zeleznik-Le NJ, Diaz MO, Rowley JD. Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia Genes Chromosomes and Cancer. 20: 185-195. PMID 9331569 DOI: 10.1002/(SICI)1098-2264(199710)20:2<185::AID-GCC9>3.0.CO;2-#  0.88
1997 Sobulo OM, Borrow J, Tomek R, Reshmi S, Harden A, Schlegelberger B, Housman D, Doggett NA, Rowley JD, Zeleznik-Le NJ. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3). Proceedings of the National Academy of Sciences of the United States of America. 94: 8732-7. PMID 9238046 DOI: 10.1073/pnas.94.16.8732  0.88
1996 Tanabe S, Bohlander SK, Vignon CV, Espinosa R, Zhao N, Strissel PL, Zeleznik-Le NJ, Rowley JD. AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12) Blood. 88: 3535-3545. PMID 8896421  0.88
1996 Tanabe S, Zeleznik-Le NJ, Kobayashi H, Vignon C, Espinosa R, LeBeau MM, Thirman MJ, Rowley JD. Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line Genes Chromosomes and Cancer. 15: 206-216. PMID 8703846 DOI: 10.1002/(SICI)1098-2264(199604)15:4<206::AID-GCC2>3.0.CO;2-5  0.88
1995 Zeleznik-Le NJ, Nucifora G, Rowley JD. The molecular biology of myeloproliferative disorders as revealed by chromosomal abnormalities Seminars in Hematology. 32: 201-219. PMID 7570064  0.88
1994 Ting JP, Painter A, Zeleznik-Le NJ, MacDonald G, Moore TM, Brown A, Schwartz BD. YB-1 DNA-binding protein represses interferon gamma activation of class II major histocompatibility complex genes. The Journal of Experimental Medicine. 179: 1605-11. PMID 8163940  0.88
1994 Zeleznik-Le NJ, Harden AM, Rowley JD. 11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene. Proceedings of the National Academy of Sciences of the United States of America. 91: 10610-4. PMID 7938000 DOI: 10.1073/pnas.91.22.10610  0.88
1992 Zeleznik-Le NJ, Itoh-Lindstrom Y, Clarke JB, Moore TL, Ting JP. The B cell-specific nuclear factor OTF-2 positively regulates transcription of the human class II transplantation gene, DRA. The Journal of Biological Chemistry. 267: 7677-82. PMID 1560002  0.88
1991 Zeleznik-Le NJ, Azizkhan JC, Ting JP. Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene. Proceedings of the National Academy of Sciences of the United States of America. 88: 1873-7. PMID 1848012  0.88
1990 Liou HC, Boothby MR, Finn PW, Davidon R, Nabavi N, Zeleznik-Le NJ, Ting JP, Glimcher LH. A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter. Science (New York, N.Y.). 247: 1581-4. PMID 2321018  0.88
1989 Zeleznik-Le NJ, Metzgar RS. Expression of CD9 antigen on normal activated human B cells Cellular Immunology. 123: 70-82. PMID 2673548 DOI: 10.1016/0008-8749(89)90269-4  0.88
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