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Jeffery M. Klco, Ph.D. - Publications

Affiliations: 
2007 Washington University, Saint Louis, St. Louis, MO 
Area:
Molecular Biology
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Michmerhuizen NL, Klco JM, Mullighan CG. Mechanistic insights and potential therapeutic targets for NUP98-rearranged hematologic malignancies. Blood. PMID 32766874 DOI: 10.1182/Blood.2020007093  0.322
2020 Nishii R, Baskin-Doerfler R, Yang W, Oak N, Zhao X, Yang W, Hoshitsuki K, Bloom M, Verbist KC, Burns MA, Li Z, Lin TN, Qian M, Moriyama T, Gastier-Foster JM, ... ... Klco JM, et al. Molecular Basis of ETV6-Mediated Predisposition to Childhood Acute Lymphoblastic Leukemia. Blood. PMID 32693409 DOI: 10.1182/Blood.2020006164  0.379
2020 Schwartz JR, Connelly JP, Pruett-Miller SM, Klco JM. Abstract B49: Modeling a pathogenic SAMD9 mutation in human induced pluripotent stem cells Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-B49  0.359
2020 Hiltenbrand R, Miller J, Klco J. Abstract B34: Cord blood CD34+ HSPCs: An in vitro model system for characterizing NUP98 fusions Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-B34  0.339
2020 Lamprecht T, Schwartz JR, Ma J, Walsh MP, Klco JM. Abstract B16: MECOM dysregulation is associated with poor outcome in pediatric therapy-related myeloid neoplasms Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-B16  0.332
2019 Elsayed AH, Rafiee R, Cao X, Raimondi S, Downing JR, Ribeiro R, Fan Y, Gruber TA, Baker S, Klco J, Rubnitz JE, Pounds S, Lamba JK. A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia. Leukemia. PMID 31645648 DOI: 10.1038/S41375-019-0604-8  0.313
2019 Miller J, Hiltenbrand R, Lamprecht T, Seth A, Abdelhamed S, Iacobucci I, Mullighan CG, Klco JM. NUP98-KDM5A Fusion Induces Hematopoietic Cell Proliferation and Alters Myelo-Erythropoietic Differentiation Blood. 134: 3775-3775. DOI: 10.1182/Blood-2019-130768  0.357
2019 Schwartz JR, Ma J, Walsh MP, Chen X, Lamprecht T, Kamens J, Newman S, Zhang J, Gruber TA, Ma X, Klco JM. Comprehensive Genomic Profiling of Pediatric Therapy-Related Myeloid Neoplasms Identifies Mecom Dysregulation to be Associated with Poor Outcome Blood. 134: 1394-1394. DOI: 10.1182/Blood-2019-128665  0.372
2019 Gruber TA, Ma J, Noort S, Liu Y, Walsh MP, Nance S, Liu Y, Wang Y, Song G, Lamprecht T, Easton J, Pigazzi M, Jarosova M, Charikleia K, Rubnitz J, ... ... Klco JM, et al. Integrative Analysis of Pediatric Acute Leukemia Identifies Immature Subtypes That Span a T Lineage and Myeloid Continuum with Distinct Prognoses Blood. 134: 918-918. DOI: 10.1182/Blood-2019-127411  0.405
2019 Schwartz JR, Wlodarski MW, Klco JM. Role of Genetic Evolution and Germline Mutations in SAMD9 and SAMD9L Genes Blood. 134: SCI-33-SCI-33. DOI: 10.1182/Blood-2019-121042  0.374
2018 Galera P, Hsu AP, Wang W, Droll S, Chen R, Schwartz JR, Klco JM, Arai S, Maese L, Zerbe C, Parta MJ, Young NS, Holland SM, Hickstein DD, Calvo KR. Donor-derived MDS/AML in families with germline GATA2 mutation. Blood. PMID 30232126 DOI: 10.1182/Blood-2018-07-861070  0.345
2018 Wong JC, Bryant V, Lamprecht T, Ma J, Walsh M, Schwartz J, Del Pilar Alzamora M, Mullighan CG, Loh ML, Ribeiro R, Downing JR, Carroll WL, Davis J, Gold S, Rogers PC, ... ... Klco JM, et al. Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes. Jci Insight. 3. PMID 30046003 DOI: 10.1172/Jci.Insight.121086  0.361
2018 Malireddi RKS, Gurung P, Mavuluri J, Dasari TK, Klco JM, Chi H, Kanneganti TD. TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. The Journal of Experimental Medicine. PMID 29500178 DOI: 10.1084/Jem.20171922  0.302
2018 Ortolano R, Parekh DS, Rosen BJ, Bryant V, Chen D, Klco JM, Raskind WH, Lieuw K. Novel V1551L Mutation in SAMD9L Inhibits Cell Cycle Progression and Results in Pancytopenia That Progresses to MDS with Monosomy 7 Blood. 132: 3863-3863. DOI: 10.1182/Blood-2018-99-120250  0.38
2018 Schwartz JR, Walsh MP, Ma J, Lamprecht T, Ribeiro RC, Klco JM. The Mutational Profile of Pediatric Therapy-Related Myeloid Neoplasms Blood. 132: 2775-2775. DOI: 10.1182/Blood-2018-99-118995  0.371
2018 Bryant V, Wong J, Schwartz J, Lamprecht T, Ma J, Mullighan C, Loh M, Shannon K, Klco J. Abstract 2063: SAMD9/SAMD9L mutations in familial monosomy 7 Cancer Research. 78: 2063-2063. DOI: 10.1158/1538-7445.Am2018-2063  0.347
2017 Schwartz JR, Ma J, Lamprecht T, Walsh M, Wang S, Bryant V, Song G, Wu G, Easton J, Kesserwan C, Nichols KE, Mullighan CG, Ribeiro RC, Klco JM. The genomic landscape of pediatric myelodysplastic syndromes. Nature Communications. 8: 1557. PMID 29146900 DOI: 10.1038/S41467-017-01590-5  0.345
2017 Cole CB, Russler-Germain DA, Ketkar S, Verdoni AM, Smith AM, Bangert CV, Helton NM, Guo M, Klco JM, O'Laughlin S, Fronick C, Fulton R, Chang GS, Petti AA, Miller CA, et al. Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies. The Journal of Clinical Investigation. PMID 28872462 DOI: 10.1172/Jci93041  0.367
2016 Faber ZJ, Chen X, Gedman AL, Boggs K, Cheng J, Ma J, Radtke I, Chao JR, Walsh MP, Song G, Andersson AK, Dang J, Dong L, Liu Y, Huether R, ... ... Klco JM, et al. The genomic landscape of core-binding factor acute myeloid leukemias. Nature Genetics. PMID 27798625 DOI: 10.1038/Ng.3709  0.375
2016 Drenberg CD, Buelow DR, Pounds SB, Wang YD, Finkelstein D, Rahija RJ, Shurtleff SA, Rubnitz JE, Inaba H, Gruber TA, Klco JM, Baker SD. Transcriptome profiling of patient derived xenograft models established from pediatric acute myeloid leukemia patients confirm maintenance of FLT3-ITD mutation. Leukemia & Lymphoma. 1-4. PMID 27248844 DOI: 10.1080/10428194.2016.1187272  0.34
2016 Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, et al. Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B lymphoblastic leukemia. Experimental Hematology. PMID 27181063 DOI: 10.1016/J.Exphem.2016.04.011  0.35
2015 Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, et al. Rapid expansion of pre-existing non-leukemic hematopoietic clones frequently follows induction therapy for de novo AML. Blood. PMID 26631115 DOI: 10.1182/Blood-2015-10-677021  0.361
2015 Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, et al. Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia. Jama. 314: 811-22. PMID 26305651 DOI: 10.1001/Jama.2015.9643  0.31
2015 Li C, Klco JM, Helton NM, George DR, Mudd JL, Miller CA, Lu C, Fulton R, O'Laughlin M, Fronick C, Wilson RK, Ley TJ. Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse. Plos One. 10: e0120585. PMID 25799070 DOI: 10.1371/Journal.Pone.0120585  0.304
2015 Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ. Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells. Leukemia. 29: 1279-89. PMID 25600023 DOI: 10.1038/Leu.2015.6  0.323
2015 Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 518: 552-5. PMID 25487151 DOI: 10.1038/Nature13968  0.344
2015 Celik H, Mallaney C, Kothari A, Ostrander EL, Eultgen E, Martens A, Miller CA, Hundal J, Klco JM, Challen GA. Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation. Blood. 125: 619-28. PMID 25416276 DOI: 10.1182/Blood-2014-08-594564  0.351
2015 Wong TN, Klco JM, Demeter R, Miller CA, Petti A, Havey N, Fulton R, Heath S, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert T, Wilson RK, et al. Non-Malignant Oligoclonal Hematopoiesis Commonly Follows Cytoreductive Chemotherapy in Adult De Novo AML Patients Blood. 126: 686-686. DOI: 10.1182/Blood.V126.23.686.686  0.376
2015 Verdoni AM, Venezia C, Klco J, Ley TJ. DNMT3A R882H Can Cooperate with FLT3-ITD to Cause AML in Mice Blood. 126: 2458-2458. DOI: 10.1182/Blood.V126.23.2458.2458  0.33
2015 Spencer D, George DR, Klco JM, Ley TJ. Reprogramming of Leukemic and Pre-Leukemic Cells from Primary Human De Novo Acute Myeloid Leukemia Samples into Induced Pluripotent Stem (iPS) Cells Blood. 126: 1862-1862. DOI: 10.1182/Blood.V126.23.1862.1862  0.392
2015 Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, et al. Abstract PR11: Genomic approaches for risk assessment in acute myeloid leukemia Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-Pr11  0.373
2015 Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, et al. Abstract PR03: Genomic approaches for risk assessment in acute myeloid leukemia Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr03  0.372
2014 Sarkaria SM, Christopher MJ, Klco JM, Ley TJ. Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro. Leukemia. 28: 2403-6. PMID 25092143 DOI: 10.1038/Leu.2014.235  0.339
2014 Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, et al. Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell. 25: 379-92. PMID 24613412 DOI: 10.1016/J.Ccr.2014.01.031  0.339
2013 Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson G, Hoadley K, Triche TJ, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, ... Klco JM, et al. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia New England Journal of Medicine. 368: 2059-2074. PMID 23634996 DOI: 10.1056/Nejmoa1301689  0.35
2013 Grieselhuber NR, Klco JM, Verdoni AM, Lamprecht T, Sarkaria SM, Wartman LD, Ley TJ. Notch signaling in acute promyelocytic leukemia. Leukemia. 27: 1548-57. PMID 23455394 DOI: 10.1038/Leu.2013.68  0.327
2013 Klco JM, Spencer DH, Lamprecht TL, Sarkaria SM, Wylie T, Magrini V, Hundal J, Walker J, Varghese N, Erdmann-Gilmore P, Lichti CF, Meyer MR, Townsend RR, Wilson RK, Mardis ER, et al. Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood. 121: 1633-43. PMID 23297133 DOI: 10.1182/Blood-2012-09-459313  0.322
2013 Verdoni AM, Cole CB, Klco JM, Ley TJ. DNMT3A R882H Overexpression Leads To Hematopoietic and Skin Alterations In Transgenic Mice Blood. 122: 479-479. DOI: 10.1182/Blood.V122.21.479.479  0.305
2013 Spencer DH, Young MA, Klco JM, Ley TJ. Comprehensive Analysis Of HOX Gene Expression and DNA Methylation From 189 Primary AMLs Demonstrates Canonical Patterns Associated With Hematopoietic Stem/Progenitors and Recurrent AML Mutations Blood. 122: 2496-2496. DOI: 10.1182/Blood.V122.21.2496.2496  0.352
2013 Li C, George DR, Helton NM, Klco JM, Mudd JL, Ley TJ. Functional Early Hematopoietic Progenitor Cells Derived From Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells Blood. 122: 2421-2421. DOI: 10.1182/Blood.V122.21.2421.2421  0.317
2012 Wartman LD, Welch JS, Uy GL, Klco JM, Lamprecht T, Varghese N, Nagarajan R, Ley TJ. Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice. Plos One. 7: e46529. PMID 23056333 DOI: 10.1371/Journal.Pone.0046529  0.32
2012 Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, ... ... Klco JM, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 150: 264-78. PMID 22817890 DOI: 10.1016/J.Cell.2012.06.023  0.37
2012 Mardis ER, Ding L, Westervelt P, Welch JS, Klco JM, DiPersio JF, Wilson RK, Ley TJ. Next-Generation Sequencing: A Discovery Tool for Blood Disorders Blood. 120: SCI-10-SCI-10. DOI: 10.1182/Blood.V120.21.Sci-10.Sci-10  0.366
2012 Klco JM, Spencer DH, Miller C, Lamprecht T, Fulton RS, Welch JS, Ding L, Wilson RK, Ley TJ. Deep Digital Sequencing Identifies an AML Subclone with Enhanced in Vitro and in Vivo Growth Properties Associated with Disease Relapse Blood. 120: 407-407. DOI: 10.1182/Blood.V120.21.407.407  0.372
2012 Li C, George DR, Havey NM, Klco JM, Ley TJ. Functional Hematopoietic Cells Derived From Mouse Embryonic Stem Cells. Blood. 120: 2304-2304. DOI: 10.1182/Blood.V120.21.2304.2304  0.301
2011 Welch JS, Westervelt P, Ding L, Larson DE, Klco JM, Kulkarni S, Wallis J, Chen K, Payton JE, Fulton RS, Veizer J, Schmidt H, Vickery TL, Heath S, Watson MA, et al. Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. Jama. 305: 1577-84. PMID 21505136 DOI: 10.1001/Jama.2011.497  0.312
2011 Wartman LD, Larson DE, Xiang Z, Ding L, Chen K, Lin L, Cahan P, Klco JM, Welch JS, Li C, Payton JE, Uy GL, Varghese N, Ries RE, Hoock M, et al. Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. The Journal of Clinical Investigation. 121: 1445-55. PMID 21436584 DOI: 10.1172/Jci45284  0.398
2011 Welch JS, Klco JM, Varghese N, Nagarajan R, Ley TJ. Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice. Blood. 117: 2460-8. PMID 21190992 DOI: 10.1182/Blood-2010-08-300087  0.336
2011 Grieselhuber NR, Klco JM, Verdoni AM, Ley TJ. Activation of Notch Signaling Is An Early Event in the Development of PML-Rara-Induced Acute Promyelocytic Leukemia (APL) Blood. 118: 2468-2468. DOI: 10.1182/Blood.V118.21.2468.2468  0.341
2010 Welch JS, Ding L, Chen K, Larson DE, Kulkarni S, Payton JE, Wallis J, Veizer J, McLellan MD, Vickery TL, Reed JP, Koboldt DC, Klco J, DiPersio JF, Mardis ER, et al. Resolution of a Clinical Dilemma with Whole Genome Sequencing, and Discovery of a New Mechanism for Generating PML-Rara: Insertional Fusion Blood. 116: 2755-2755. DOI: 10.1182/Blood.V116.21.2755.2755  0.343
2009 Klco JM, Sen S, Hansen JL, Lyngsø C, Nikiforovich GV, Sheikh SP, Baranski TJ. Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence. The Febs Journal. 276: 2786-800. PMID 19459935 DOI: 10.1111/J.1742-4658.2009.07002.X  0.645
2008 Hagemann IS, Miller DL, Klco JM, Nikiforovich GV, Baranski TJ. Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling. The Journal of Biological Chemistry. 283: 7763-75. PMID 18195008 DOI: 10.1074/Jbc.M709467200  0.703
2007 Sen S, Klco JM, Hansen JL, Nikiforovich GV, Sheikh SP, Baranski TJ. Dimerization/oligomerization in G protein‐coupled receptors (GPCRs) involve the participation of all transmembrane domains The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A613-A  0.626
2006 Klco JM, Nikiforovich GV, Baranski TJ. Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop. The Journal of Biological Chemistry. 281: 12010-9. PMID 16505476 DOI: 10.1074/Jbc.M600548200  0.658
2005 Klco JM, Wiegand CB, Narzinski K, Baranski TJ. Essential role for the second extracellular loop in C5a receptor activation. Nature Structural & Molecular Biology. 12: 320-6. PMID 15768031 DOI: 10.1038/Nsmb913  0.664
2003 Klco JM, Lassere TB, Baranski TJ. C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. The Journal of Biological Chemistry. 278: 35345-53. PMID 12835319 DOI: 10.1074/Jbc.M305606200  0.657
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