Neil Segil - Publications

Affiliations: 
Genetic, Molecular, and Cell Biology University of Southern California, Los Angeles, CA, United States 
Area:
Cell Biology, Molecular Biology, Neuroscience Biology

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tao L, Yu HV, Llamas J, Trecek T, Wang X, Stojanova Z, Groves AK, Segil N. Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration. Developmental Cell. PMID 34331868 DOI: 10.1016/j.devcel.2021.07.003  1
2021 Yu HV, Tao L, Llamas J, Wang X, Nguyen JD, Trecek T, Segil N. POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34266958 DOI: 10.1073/pnas.2105137118  1
2021 Kastan N, Gnedeva K, Alisch T, Petelski AA, Huggins DJ, Chiaravalli J, Aharanov A, Shakked A, Tzahor E, Nagiel A, Segil N, Hudspeth AJ. Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues. Nature Communications. 12: 3100. PMID 34035288 DOI: 10.1038/s41467-021-23395-3  0.01
2021 Xu P, Yu HV, Tseng KC, Flath M, Fabian P, Segil N, Crump JG. Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation. Elife. 10. PMID 33501917 DOI: 10.7554/eLife.63595  1
2020 Menendez L, Trecek T, Gopalakrishnan S, Tao L, Markowitz AL, Yu HV, Wang X, Llamas J, Huang C, Lee J, Kalluri R, Ichida J, Segil N. Generation of inner ear hair cells by direct lineage conversion of primary somatic cells. Elife. 9. PMID 32602462 DOI: 10.7554/Elife.55249  1
2020 Gnedeva K, Wang X, McGovern MM, Barton M, Tao L, Trecek T, Monroe TO, Llamas J, Makmura W, Martin JF, Groves AK, Warchol M, Segil N. Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal. Proceedings of the National Academy of Sciences of the United States of America. PMID 32482884 DOI: 10.1073/Pnas.2000175117  1
2020 Menendez L, Trecek T, Gopalakrishnan S, Tao L, Markowitz AL, Yu HV, Wang X, Llamas J, Huang C, Lee J, Kalluri R, Ichida J, Segil N. Author response: Generation of inner ear hair cells by direct lineage conversion of primary somatic cells Elife. DOI: 10.7554/Elife.55249.Sa2  1
2019 Jen HI, Hill MC, Tao L, Sheng K, Cao W, Zhang H, Yu HV, Llamas J, Zong C, Martin JF, Segil N, Groves AK. Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1. Elife. 8. PMID 31033441 DOI: 10.7554/Elife.44328  1
2019 Jen H, Hill MC, Tao L, Sheng K, Cao W, Zhang H, Yu HV, Llamas J, Zong C, Martin JF, Segil N, Groves AK. Author response: Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1 Elife. DOI: 10.7554/Elife.44328.032  1
2018 Gnedeva K, Hudspeth AJ, Segil N. Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs. Journal of Visualized Experiments : Jove. PMID 29912206 DOI: 10.3791/57527  0.01
2017 Maletic-Savatic M, Semerci F, Choi WT, Bajic A, Thakkar A, Encinas JM, Depreux F, Segil N, Groves AK. Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance. Elife. 6. PMID 28699891 DOI: 10.7554/Elife.24660  1
2017 Teng CS, Yen HY, Barske L, Smith B, Llamas J, Segil N, Go J, Sanchez-Lara PA, Maxson RE, Crump JG. Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. Scientific Reports. 7: 2497. PMID 28566723 DOI: 10.1038/S41598-017-02574-7  1
2017 Semerci F, Choi WT, Bajic A, Thakkar A, Encinas JM, Depreux F, Segil N, Groves AK, Maletic-Savatic M. Author response: Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance Elife. DOI: 10.7554/Elife.24660.016  1
2016 Basch ML, Brown RM, Jen HI, Semerci F, Depreux F, Edlund R, Zhang H, Norton CR, Gridley T, Cole SE, Doetzlhofer A, Maletic-Savatic M, Segil N, Groves AK. Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates. Elife. 5. PMID 27966429 DOI: 10.7554/Elife.19921  1
2016 Stojanova ZP, Kwan T, Segil N. Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development (Cambridge, England). 143: 1632. PMID 27143757 DOI: 10.1242/dev.137976  1
2016 Rainey RN, Ng SY, Llamas J, van der Horst GT, Segil N. Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 4758-70. PMID 27122034 DOI: 10.1523/Jneurosci.3890-15.2016  1
2016 Abdolazimi Y, Stojanova Z, Segil N. Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development (Cambridge, England). 143: 841-50. PMID 26932672 DOI: 10.1242/Dev.129320  1
2016 Basch ML, Brown RM, Jen H, Semerci F, Depreux F, Edlund RK, Zhang H, Norton CR, Gridley T, Cole SE, Doetzlhofer A, Maletic-Savatic M, Segil N, Groves AK. Author response: Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates Elife. DOI: 10.7554/Elife.19921.015  1
2015 Stojanova ZP, Kwan T, Segil N. Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development (Cambridge, England). 142: 3529-36. PMID 26487780 DOI: 10.1242/Dev.126763  1
2015 Tao L, Segil N. Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner ear. Frontiers in Cellular Neuroscience. 9: 190. PMID 26052268 DOI: 10.3389/Fncel.2015.00190  1
2015 Nagtegaal AP, Rainey RN, van der Pluijm I, Brandt RM, van der Horst GT, Borst JG, Segil N. Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4280-6. PMID 25762674 DOI: 10.1523/Jneurosci.5063-14.2015  1
2013 Worman HJ, Segil N. Nucleocytoplasmic connections and deafness. The Journal of Clinical Investigation. 123: 553-5. PMID 23348730 DOI: 10.1172/Jci67454  1
2012 White PM, Stone JS, Groves AK, Segil N. EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals. Developmental Biology. 363: 191-200. PMID 22230616 DOI: 10.1016/J.Ydbio.2011.12.035  1
2011 Basch ML, Ohyama T, Segil N, Groves AK. Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 8046-58. PMID 21632926 DOI: 10.1523/Jneurosci.6671-10.2011  1
2010 Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK. BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15044-51. PMID 21068310 DOI: 10.1523/Jneurosci.3547-10.2010  1
2009 Kwan T, White PM, Segil N. Development and regeneration of the inner ear. Annals of the New York Academy of Sciences. 1170: 28-33. PMID 19686102 DOI: 10.1111/J.1749-6632.2009.04484.X  1
2009 Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N. Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Developmental Cell. 16: 58-69. PMID 19154718 DOI: 10.1016/J.Devcel.2008.11.008  1
2008 Jayasena CS, Ohyama T, Segil N, Groves AK. Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development (Cambridge, England). 135: 2251-61. PMID 18495817 DOI: 10.1242/Dev.017905  1
2007 Raft S, Koundakjian EJ, Quinones H, Jayasena CS, Goodrich LV, Johnson JE, Segil N, Groves AK. Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development. Development (Cambridge, England). 134: 4405-15. PMID 18039969 DOI: 10.1242/Dev.009118  1
2007 Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel MF, Segil N, Pirvola U. p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1434-44. PMID 17287518 DOI: 10.1523/Jneurosci.4956-06.2007  1
2006 White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N. Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature. 441: 984-7. PMID 16791196 DOI: 10.1038/Nature04849  1
2006 Lee YS, Liu F, Segil N. A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development. Development (Cambridge, England). 133: 2817-26. PMID 16790479 DOI: 10.1242/Dev.02453  1
2006 Doetzlhofer A, White P, Lee YS, Groves A, Segil N. Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea. Brain Research. 1091: 282-8. PMID 16616734 DOI: 10.1016/J.Brainres.2006.02.071  1
2006 Wang J, Hamblet NS, Mark S, Dickinson ME, Brinkman BC, Segil N, Fraser SE, Chen P, Wallingford JB, Wynshaw-Boris A. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (Cambridge, England). 133: 1767-78. PMID 16571627 DOI: 10.1242/Dev.02347  1
2004 Radde-Gallwitz K, Pan L, Gan L, Lin X, Segil N, Chen P. Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. The Journal of Comparative Neurology. 477: 412-21. PMID 15329890 DOI: 10.1002/Cne.20257  1
2004 Doetzlhofer A, White PM, Johnson JE, Segil N, Groves AK. In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme. Developmental Biology. 272: 432-47. PMID 15282159 DOI: 10.1016/J.Ydbio.2004.05.013  1
2003 Lumpkin EA, Collisson T, Parab P, Omer-Abdalla A, Haeberle H, Chen P, Doetzlhofer A, White P, Groves A, Segil N, Johnson JE. Math1-driven GFP expression in the developing nervous system of transgenic mice. Gene Expression Patterns : Gep. 3: 389-95. PMID 12915300 DOI: 10.1016/S1567-133X(03)00089-9  1
2003 Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel MF, Segil N. Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nature Cell Biology. 5: 422-6. PMID 12717441 DOI: 10.1038/Ncb976  1
2002 Chen P, Johnson JE, Zoghbi HY, Segil N. The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. Development (Cambridge, England). 129: 2495-505. PMID 11973280  1
2001 Morishita H, Makishima T, Kaneko C, Lee YS, Segil N, Takahashi K, Kuraoka A, Nakagawa T, Nabekura J, Nakayama K, Nakayama KI. Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochemical and Biophysical Research Communications. 284: 142-9. PMID 11374883 DOI: 10.1006/Bbrc.2001.4939  1
1999 Chen P, Segil N. p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti Development. 126: 1581-1590. PMID 10079221  1
1997 Inamotc S, Segil N, Pan ZQ, Kimura M, Roeder RG. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of Octamer transcription factors Journal of Biological Chemistry. 272: 29852-29858. PMID 9368058 DOI: 10.1074/Jbc.272.47.29852  1
1996 Segil N, Guermah M, Hoffmann A, Roeder RG, Heintz N. Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization. Genes & Development. 10: 2389-400. PMID 8843192 DOI: 10.1101/Gad.10.19.2389  1
1992 Courvalin JC, Segil N, Blobel G, Worman HJ. The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase. The Journal of Biological Chemistry. 267: 19035-8. PMID 1326541  1
1991 Roberts SB, Segil N, Heintz N. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. Science (New York, N.Y.). 253: 1022-6. PMID 1887216 DOI: 10.1126/Science.1887216  1
1991 Segil N, Roberts SB, Heintz N. Cell-cycle-regulated phosphorylation of the transcription factor Oct-1. Cold Spring Harbor Symposia On Quantitative Biology. 56: 285-92. PMID 1819493 DOI: 10.1101/Sqb.1991.056.01.035  1
1991 Segil N, Roberts SB, Heintz N. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. Science (New York, N.Y.). 254: 1814-6. PMID 1684878 DOI: 10.1126/Science.1684878  1
1989 Kelley D, Sassoon D, Segil N, Scudder M. Development and hormone regulation of androgen receptor levels in the sexually dimorphic larynx of Xenopus laevis. Developmental Biology. 131: 111-8. PMID 2909399 DOI: 10.1016/S0012-1606(89)80042-9  1
1988 Segil N, Shrutkowski A, Dworkin MB, Dworkin-Rastl E. Enolase isoenzymes in adult and developing Xenopus laevis and characterization of a cloned enolase sequence Biochemical Journal. 251: 31-39. PMID 3390159 DOI: 10.1042/Bj2510031  1
1987 Segil N, Silverman L, Kelley DB. Androgen-binding levels in a sexually dimorphic muscle of Xenopus laevis. General and Comparative Endocrinology. 66: 95-101. PMID 3495467 DOI: 10.1016/0016-6480(87)90354-6  1
1987 Dworkin MB, Segil N, Dworkin-Rastl E. Pyruvate kinase isozymes in oocytes and embryos from the frog Xenopus laevis Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 88: 743-749. PMID 3427912 DOI: 10.1016/0305-0491(87)90238-0  1
1987 Grober MS, Bass AH, Burd G, Marchaterre MA, Segil N, Scholz K, Hodgson T. The nervus terminalis ganglion in Anguilla rostrata: an immunocytochemical and HRP histochemical analysis. Brain Research. 436: 148-52. PMID 3319052 DOI: 10.1016/0006-8993(87)91567-8  1
1986 Sassoon D, Segil N, Kelley D. Androgen-induced myogenesis and chondrogenesis in the larynx of Xenopus laevis. Developmental Biology. 113: 135-40. PMID 3943661 DOI: 10.1016/0012-1606(86)90115-6  1
1986 Bass AH, Segil N, Kelley DB. Androgen binding in the brain and electric organ of a mormyrid fish. Journal of Comparative Physiology. a, Sensory, Neural, and Behavioral Physiology. 159: 535-44. PMID 3491207 DOI: 10.1007/Bf00604173  1
1984 Trenkner E, Smith D, Segil N. Is cerebellar granule cell migration regulated by an internal clock? Journal of Neuroscience. 4: 2850-2855. PMID 6502207 DOI: 10.1523/Jneurosci.04-11-02850.1984  1
1976 Powell JA, Segil N. Secondary lens formation caused by implantation of pituitary into the eyes of the newt, Notophthalmus Developmental Biology. 52: 128-140. PMID 964451 DOI: 10.1016/0012-1606(76)90013-0  1
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