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Nicholas S. Heaton, Ph.D. - Publications

Affiliations: 
2012 Microbiology University of Chicago, Chicago, IL 
Area:
Microbiology Biology, Virology Biology
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chaves LCS, Orr-Burks N, Vanover D, Mosur VV, Hosking SR, Kumar E K P, Jeong H, Jung Y, Assumpção JAF, Peck HE, Nelson SL, Burke KN, Garrison MA, Arthur RA, Claussen H, ... Heaton NS, et al. mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA. Plos Pathogens. 20: e1012345. PMID 38968329 DOI: 10.1371/journal.ppat.1012345  0.395
2024 Munir M, Embry A, Doench JG, Heaton NS, Wilen CB, Orchard RC. Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB dependent IFITM3 expression. The Journal of Biological Chemistry. 107153. PMID 38462163 DOI: 10.1016/j.jbc.2024.107153  0.462
2023 Munir M, Embry A, Doench JG, Heaton NS, Wilen CB, Orchard RC. Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB. Biorxiv : the Preprint Server For Biology. PMID 37808733 DOI: 10.1101/2023.09.29.560128  0.469
2023 Hamele CE, Spurrier MA, Leonard RA, Heaton NS. Segmented, Negative-Sense RNA Viruses of Humans: Genetic Systems and Experimental Uses of Reporter Strains. Annual Review of Virology. 10: 261-282. PMID 37774125 DOI: 10.1146/annurev-virology-111821-120445  0.342
2023 Bacsik DJ, Dadonaite B, Butler A, Greaney AJ, Heaton NS, Bloom JD. Influenza virus transcription and progeny production are poorly correlated in single cells. Elife. 12. PMID 37675839 DOI: 10.7554/eLife.86852  0.44
2023 Leonard RA, Rao VN, Bartlett A, Froggatt HM, Luftig MA, Heaton BE, Heaton NS. A low-background, fluorescent assay to evaluate inhibitors of diverse viral proteases. Journal of Virology. 97: e0059723. PMID 37578235 DOI: 10.1128/jvi.00597-23  0.309
2022 Schott BH, Wang L, Zhu X, Harding AT, Ko ER, Bourgeois JS, Washington EJ, Burke TW, Anderson J, Bergstrom E, Gardener Z, Paterson S, Brennan RG, Chiu C, McClain MT, ... ... Heaton NS, et al. Single-cell genome-wide association reveals that a nonsynonymous variant in confers increased susceptibility to influenza virus. Cell Genomics. 2. PMID 36465279 DOI: 10.1016/j.xgen.2022.100207  0.342
2022 Trimarco JD, Nelson SL, Chaparian RR, Wells AI, Murray NB, Azadi P, Coyne CB, Heaton NS. Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection. Nature Communications. 13: 6456. PMID 36309510 DOI: 10.1038/s41467-022-34111-0  0.531
2022 Yaron TM, Heaton BE, Levy TM, Johnson JL, Jordan TX, Cohen BM, Kerelsky A, Lin TY, Liberatore KM, Bulaon DK, Van Nest SJ, Koundouros N, Kastenhuber ER, Mercadante MN, Shobana-Ganesh K, ... ... Heaton NS, et al. Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. Science Signaling. 15: eabm0808. PMID 36282911 DOI: 10.1126/scisignal.abm0808  0.317
2022 Zhu X, Trimarco JD, Williams CA, Barrera A, Reddy TE, Heaton NS. ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection. Cell Reports. 111540. PMID 36243002 DOI: 10.1016/j.celrep.2022.111540  0.366
2022 Hamele CE, Russell AB, Heaton NS. Profiling of Individual Multiciliated Cells during Acute Influenza A Virus Infection. Journal of Virology. 96: e0050522. PMID 35867557 DOI: 10.1128/jvi.00505-22  0.446
2022 Froggatt HM, Heaton NS. Nonrespiratory sites of influenza-associated disease: mechanisms and experimental systems for continued study. The Febs Journal. PMID 35060315 DOI: 10.1111/febs.16363  0.451
2022 Trimarco JD, Heaton NS. From high-throughput to therapeutic: host-directed interventions against influenza viruses. Current Opinion in Virology. 53: 101198. PMID 35030353 DOI: 10.1016/j.coviro.2021.12.014  0.426
2021 Froggatt HM, Burke KN, Chaparian RR, Miranda HA, Zhu X, Chambers BS, Heaton NS. Influenza A virus segments five and six can harbor artificial introns allowing expanded coding capacity. Plos Pathogens. 17: e1009951. PMID 34570829 DOI: 10.1371/journal.ppat.1009951  0.416
2021 Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, ... ... Heaton NS, et al. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science (New York, N.Y.). PMID 34285133 DOI: 10.1126/science.abg5827  0.641
2021 Trimarco JD, Heaton BE, Chaparian RR, Burke KN, Binder RA, Gray GC, Smith CM, Menachery VD, Heaton NS. TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2. Plos Pathogens. 17: e1009599. PMID 34043740 DOI: 10.1371/journal.ppat.1009599  0.438
2021 Luo Z, Girton AW, Heaton BE, Heaton NS. Engineered influenza virions reveal the contributions of non-hemagglutinin structural proteins to vaccine mediated protection. Journal of Virology. PMID 33658342 DOI: 10.1128/JVI.02021-20  0.334
2020 Katsura H, Sontake V, Tata A, Kobayashi Y, Edwards CE, Heaton BE, Konkimalla A, Asakura T, Mikami Y, Fritch EJ, Lee PJ, Heaton NS, Boucher RC, Randell SH, Baric RS, et al. Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. Cell Stem Cell. PMID 33128895 DOI: 10.1016/j.stem.2020.10.005  0.31
2020 Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, ... ... Heaton NS, et al. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 . Biorxiv : the Preprint Server For Biology. PMID 32908976 DOI: 10.1101/2020.08.31.274639  0.646
2020 Dumm RE, Wellford SA, Moseman EA, Heaton NS. Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses. Cell Reports. 32: 108103. PMID 32877682 DOI: 10.1016/J.Celrep.2020.108103  0.559
2020 Froggatt HM, Heaton BE, Heaton NS. Development of a fluorescence based, high-throughput SARS-CoV-2 3CL reporter assay. Journal of Virology. PMID 32843534 DOI: 10.1128/Jvi.01265-20  0.482
2020 Heaton BE, Trimarco JD, Hamele CE, Harding AT, Tata A, Zhu X, Tata PR, Smith CM, Heaton NS. SRSF protein kinases 1 and 2 are essential host factors for human coronaviruses including SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 32817937 DOI: 10.1101/2020.08.14.251207  0.401
2020 Abbott TR, Dhamdhere G, Liu Y, Lin X, Goudy L, Zeng L, Chemparathy A, Chmura S, Heaton NS, Debs R, Pande T, Endy D, La Russa MF, Lewis DB, Qi LS. Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza. Cell. PMID 32353252 DOI: 10.1016/J.Cell.2020.04.020  0.541
2019 Harding AT, Haas GD, Chambers BS, Heaton NS. Influenza viruses that require 10 genomic segments as antiviral therapeutics. Plos Pathogens. 15: e1008098. PMID 31730644 DOI: 10.1371/Journal.Ppat.1008098  0.511
2019 Fiege JK, Stone IA, Dumm RE, Waring BM, Fife BT, Agudo J, Brown BD, Heaton NS, Langlois RA. Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. Plos Pathogens. 15: e1008077. PMID 31557273 DOI: 10.1371/Journal.Ppat.1008077  0.37
2019 Dumm RE, Heaton NS. The Development and Use of Reporter Influenza B Viruses. Viruses. 11. PMID 31404985 DOI: 10.3390/V11080736  0.571
2019 Chambers BS, Heaton BE, Rausch K, Dumm RE, Hamilton JR, Cherry S, Heaton NS. DNA mismatch repair is required for the host innate response and controls cellular fate after influenza virus infection. Nature Microbiology. PMID 31358986 DOI: 10.1038/S41564-019-0509-3  0.754
2019 Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, ... Heaton NS, et al. Control of antiviral innate immune response by protein geranylgeranylation. Science Advances. 5: eaav7999. PMID 31149635 DOI: 10.1126/Sciadv.Aav7999  0.505
2019 Dumm RE, Fiege JK, Waring BM, Kuo CT, Langlois RA, Heaton NS. Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function. Nature Communications. 10: 779. PMID 30770807 DOI: 10.1038/S41467-019-08617-Z  0.537
2018 Fulton BO, Sun W, Heaton NS, Palese P. The influenza B virus hemagglutinin head domain is less tolerant to transposon mutagenesis than that of the influenza A virus. Journal of Virology. PMID 29899093 DOI: 10.1128/Jvi.00754-18  0.806
2018 Harding AT, Heaton NS. Efforts to Improve the Seasonal Influenza Vaccine. Vaccines. 6. PMID 29601497 DOI: 10.3390/Vaccines6020019  0.4
2017 Heaton NS, Cullen BR. Viruses hijack a long non-coding RNA. Nature. 552: 184-185. PMID 32080446 DOI: 10.1038/D41586-017-07692-W  0.442
2017 Courtney DG, Kennedy EM, Dumm RE, Bogerd HP, Tsai K, Heaton NS, Cullen BR. Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication. Cell Host & Microbe. 22: 377-386.e5. PMID 28910636 DOI: 10.1016/J.Chom.2017.08.004  0.412
2017 Heaton BE, Kennedy EM, Dumm RE, Harding AT, Sacco MT, Sachs D, Heaton NS. A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor. Cell Reports. 20: 1503-1512. PMID 28813663 DOI: 10.1016/J.Celrep.2017.07.060  0.546
2017 Heaton NS. Revisiting the concept of a cytopathic viral infection. Plos Pathogens. 13: e1006409. PMID 28727844 DOI: 10.1371/Journal.Ppat.1006409  0.459
2017 Harding AT, Heaton BE, Dumm RE, Heaton NS. Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs. Mbio. 8. PMID 28588131 DOI: 10.1128/Mbio.00669-17  0.437
2016 Hamilton JR, Sachs D, Lim JK, Langlois RA, Palese P, Heaton NS. Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001854 DOI: 10.1073/Pnas.1522376113  0.789
2016 Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs DH, Hamilton J, Leon PE, Chawdury A, Tripathi S, et al. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity. 44: 46-58. PMID 26789921 DOI: 10.1016/J.Immuni.2015.12.017  0.828
2016 Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, et al. Corrections to Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. (Immunity 44, 46-58, January 19, 2016) Immunity. 44: 438. DOI: 10.1016/J.Immuni.2016.01.016  0.821
2015 Fulton BO, Palese P, Heaton NS. Replication-Competent Influenza B Reporter Viruses as Tools for Screening Antivirals and Antibodies. Journal of Virology. 89: 12226-31. PMID 26401044 DOI: 10.1128/Jvi.02164-15  0.808
2015 Fulton BO, Sachs D, Beaty SM, Won ST, Lee B, Palese P, Heaton NS. Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins. Cell Reports. 11: 1331-8. PMID 26004185 DOI: 10.1016/J.Celrep.2015.04.054  0.814
2014 Heaton NS, Langlois RA, Sachs D, Lim JK, Palese P, tenOever BR. Long-term survival of influenza virus infected club cells drives immunopathology. The Journal of Experimental Medicine. 211: 1707-14. PMID 25135297 DOI: 10.1084/Jem.20140488  0.674
2013 Heaton NS, Sachs D, Chen CJ, Hai R, Palese P. Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: 20248-53. PMID 24277853 DOI: 10.1073/Pnas.1320524110  0.748
2013 Dolan PT, Zhang C, Khadka S, Arumugaswami V, Vangeloff AD, Heaton NS, Sahasrabudhe S, Randall G, Sun R, LaCount DJ. Identification and comparative analysis of hepatitis C virus-host cell protein interactions. Molecular Biosystems. 9: 3199-209. PMID 24136289 DOI: 10.1039/C3Mb70343F  0.706
2013 Margine I, Krammer F, Hai R, Heaton NS, Tan GS, Andrews SA, Runstadler JA, Wilson PC, Albrecht RA, García-Sastre A, Palese P. Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses. Journal of Virology. 87: 10435-46. PMID 23903831 DOI: 10.1128/Jvi.01715-13  0.779
2013 Heaton NS, Leyva-Grado VH, Tan GS, Eggink D, Hai R, Palese P. In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies. Journal of Virology. 87: 8272-81. PMID 23698304 DOI: 10.1128/Jvi.00969-13  0.766
2013 Chou YY, Heaton NS, Gao Q, Palese P, Singer RH, Singer R, Lionnet T. Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis. Plos Pathogens. 9: e1003358. PMID 23671419 DOI: 10.1371/Journal.Ppat.1003358  0.738
2012 Chukkapalli V, Heaton NS, Randall G. Lipids at the interface of virus-host interactions. Current Opinion in Microbiology. 15: 512-8. PMID 22682978 DOI: 10.1016/J.Mib.2012.05.013  0.71
2012 Coller KE, Heaton NS, Berger KL, Cooper JD, Saunders JL, Randall G. Molecular determinants and dynamics of hepatitis C virus secretion. Plos Pathogens. 8: e1002466. PMID 22241992 DOI: 10.1371/Journal.Ppat.1002466  0.663
2011 Heaton NS, Randall G. Dengue virus and autophagy. Viruses. 3: 1332-41. PMID 21994782 DOI: 10.3390/V3081332  0.732
2011 Khadka S, Vangeloff AD, Zhang C, Siddavatam P, Heaton NS, Wang L, Sengupta R, Sahasrabudhe S, Randall G, Gribskov M, Kuhn RJ, Perera R, LaCount DJ. A physical interaction network of dengue virus and human proteins. Molecular & Cellular Proteomics : McP. 10: M111.012187. PMID 21911577 DOI: 10.1074/Mcp.M111.012187  0.694
2011 Heaton NS, Randall G. Multifaceted roles for lipids in viral infection. Trends in Microbiology. 19: 368-75. PMID 21530270 DOI: 10.1016/J.Tim.2011.03.007  0.738
2010 Heaton NS, Randall G. Dengue virus-induced autophagy regulates lipid metabolism. Cell Host & Microbe. 8: 422-32. PMID 21075353 DOI: 10.1016/J.Chom.2010.10.006  0.711
2010 Heaton NS, Perera R, Berger KL, Khadka S, Lacount DJ, Kuhn RJ, Randall G. Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 17345-50. PMID 20855599 DOI: 10.1073/Pnas.1010811107  0.7
2009 Coller KE, Berger KL, Heaton NS, Cooper JD, Yoon R, Randall G. RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. Plos Pathogens. 5: e1000702. PMID 20041214 DOI: 10.1371/Journal.Ppat.1000702  0.66
2009 Berger KL, Cooper JD, Heaton NS, Yoon R, Oakland TE, Jordan TX, Mateu G, Grakoui A, Randall G. Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. Proceedings of the National Academy of Sciences of the United States of America. 106: 7577-82. PMID 19376974 DOI: 10.1073/Pnas.0902693106  0.71
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