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Michael J. Emanuele, Ph.D. - Publications

Affiliations: 
2007 University of Virginia, Charlottesville, VA 
 2013- Pharmacology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
cell cycle, mitosis, protein stability, ubiquitin, cancer, genetics, cell biology
Website:
https://www.med.unc.edu/pharm/people/primaryfaculty/michael-j.-emanuele
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bolhuis DL, Fleifel D, Bonacci T, Wang X, Mouery BL, Cook JG, Brown NG, Emanuele MJ. USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination. Biorxiv : the Preprint Server For Biology. PMID 39282338 DOI: 10.1101/2024.09.03.610997  0.306
2024 Mouery RD, Lukasik K, Hsu C, Bonacci T, Bolhuis DL, Wang X, Mills CA, Toomer ED, Canterbury OG, Robertson KC, Branigan TB, Brown NG, Herring LE, Gupton SL, Emanuele MJ. Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton. Cell Reports. 43: 114510. PMID 39018246 DOI: 10.1016/j.celrep.2024.114510  0.349
2023 Mouery RD, Hsu C, Bonacci T, Bolhuis DL, Wang X, Mills CA, Toomer ED, Canterbury OG, Robertson KC, Branigan TB, Brown NG, Herring LE, Emanuele MJ. Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control. Biorxiv : the Preprint Server For Biology. PMID 37873169 DOI: 10.1101/2023.10.11.561963  0.353
2021 Enrico TP, Stallaert W, Wick ET, Ngoi P, Wang X, Rubin SM, Brown NG, Purvis J, Emanuele MJ. Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. Elife. 10. PMID 34851822 DOI: 10.7554/eLife.70691  0.321
2021 Wasserman D, Nachum S, Noach-Hirsh M, Auerbach N, Sheinberger-Chorni E, Enrico TP, Lahmi R, Emanuele MJ, Tzur A. Elucidating Human Mitosis Using an Anaphase-Like Cell-Free System. Methods in Molecular Biology (Clifton, N.J.). 2329: 143-164. PMID 34085221 DOI: 10.1007/978-1-0716-1538-6_11  0.35
2020 Franks JL, Martinez-Chacin RC, Wang X, Tiedemann RL, Bonacci T, Choudhury R, Bolhuis DL, Enrico TP, Mouery RD, Damrauer JS, Yan F, Harrison JS, Major MB, Hoadley KA, Suzuki A, ... ... Emanuele MJ, et al. In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators. Plos Biology. 18: e3000975. PMID 33306668 DOI: 10.1371/journal.pbio.3000975  0.334
2020 Emanuele MJ, Enrico TP, Mouery RD, Wasserman D, Nachum S, Tzur A. Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin. Trends in Cell Biology. PMID 32513610 DOI: 10.1016/J.Tcb.2020.05.002  0.404
2020 Martinez-Chacin RC, Bodrug T, Bolhuis DL, Kedziora KM, Bonacci T, Ordureau A, Gibbs ME, Weissmann F, Qiao R, Grant GD, Cook JG, Peters JM, Wade Harper J, Emanuele MJ, Brown NG. Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming. Nature Structural & Molecular Biology. PMID 32393902 DOI: 10.1038/S41594-020-0424-6  0.32
2020 Bonacci T, Emanuele MJ. Dissenting degradation: Deubiquitinases in cell cycle and cancer. Seminars in Cancer Biology. PMID 32201366 DOI: 10.1016/J.Semcancer.2020.03.008  0.413
2020 Wasserman D, Nachum S, Cohen M, Enrico TP, Noach-Hirsh M, Parasol J, Zomer-Polak S, Auerbach N, Sheinberger-Chorni E, Nevenzal H, Levi-Dadon N, Wang X, Lahmi R, Michaely E, Gerber D, ... Emanuele MJ, et al. Cell cycle oscillators underlying orderly proteolysis of E2F8. Molecular Biology of the Cell. mbcE19120725. PMID 31995441 DOI: 10.1091/Mbc.E19-12-0725  0.405
2020 McDonald IM, Grant GD, East MP, Gilbert TS, Wilkerson EM, Goldfarb D, Beri J, Herring LE, Vaziri C, Cook JG, Emanuele MJ, Graves LM. Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells. The Journal of Biological Chemistry. PMID 31896573 DOI: 10.1074/Jbc.Ra119.011083  0.352
2019 Blake DR, Vaseva AV, Hodge RG, Kline MP, Gilbert TSK, Tyagi V, Huang D, Whiten GC, Larson JE, Wang X, Pearce KH, Herring LE, Graves LM, Frye SV, Emanuele MJ, et al. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Science Signaling. 12. PMID 31311847 DOI: 10.1126/Scisignal.Aav7259  0.357
2019 Bonacci T, Emanuele MJ. Impressionist portraits of mitotic exit: APC/C, K11-linked ubiquitin chains and Cezanne. Cell Cycle (Georgetown, Tex.). PMID 30874463 DOI: 10.1080/15384101.2019.1593646  0.411
2019 Arceci A, Bonacci T, Wang X, Stewart K, Damrauer JS, Hoadley KA, Emanuele MJ. FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer. Cell Reports. 26: 3076-3086.e6. PMID 30865895 DOI: 10.1016/J.Celrep.2019.02.054  0.393
2018 Kernan J, Bonacci T, Emanuele MJ. Who guards the guardian? Mechanisms that restrain APC/C during the cell cycle. Biochimica Et Biophysica Acta. Molecular Cell Research. 1865: 1924-1933. PMID 30290241 DOI: 10.1016/J.Bbamcr.2018.09.011  0.429
2018 Bonacci T, Suzuki A, Grant GD, Stanley N, Cook JG, Brown NG, Emanuele MJ. Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates. The Embo Journal. PMID 29973362 DOI: 10.15252/Embj.201798701  0.414
2017 Dronamraju R, Jha DK, Eser U, Adams AT, Dominguez D, Choudhury R, Chiang YC, Rathmell WK, Emanuele MJ, Churchman LS, Strahl BD. Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity. Nucleic Acids Research. PMID 29294086 DOI: 10.1093/Nar/Gkx1276  0.387
2017 Gray KM, Kaifer KA, Baillat D, Wen Y, Bonacci TR, Ebert AD, Raimer AC, Spring AM, Have ST, Glascock JJ, Gupta K, Van Duyne GD, Emanuele MJ, Lamond AI, Wagner EJ, et al. Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCF(Slmb) degron. Molecular Biology of the Cell. PMID 29167380 DOI: 10.1091/Mbc.E17-11-0627  0.333
2017 Choudhury R, Bonacci T, Wang X, Truong A, Arceci A, Zhang Y, Mills CA, Kernan JL, Liu P, Emanuele MJ. The E3 Ubiquitin Ligase SCF(Cyclin F) Transmits AKT Signaling to the Cell-Cycle Machinery. Cell Reports. 20: 3212-3222. PMID 28954236 DOI: 10.1016/J.Celrep.2017.08.099  0.38
2017 Mills CA, Suzuki A, Arceci A, Mo JY, Duncan A, Salmon ED, Emanuele MJ. Nucleolar and spindle-associated protein 1 (NUSAP1) interacts with a SUMO E3 ligase complex during chromosome segregation. The Journal of Biological Chemistry. PMID 28900032 DOI: 10.1074/Jbc.M117.796045  0.489
2017 Yi JJ, Paranjape SR, Walker MP, Choudhury R, Wolter JM, Fragola G, Emanuele MJ, Major MB, Zylka MJ. The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome. The Journal of Biological Chemistry. PMID 28559284 DOI: 10.1074/Jbc.M117.788448  0.325
2017 Wang X, Arceci A, Bird K, Mills CA, Choudhury R, Kernan JL, Zhou C, Bae-Jump V, Bowers A, Emanuele MJ. VprBP/DCAF1 regulates the degradation and non-proteolytic activation of the cell cycle transcription factor FoxM1. Molecular and Cellular Biology. PMID 28416635 DOI: 10.1128/Mcb.00609-16  0.391
2016 Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills CA, Kernan JL, Branigan TB, DeCaprio JA, Burke DJ, Emanuele MJ. APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry. Cell Reports. 16: 3359-72. PMID 27653696 DOI: 10.1016/J.Celrep.2016.08.058  0.351
2016 Emanuele MJ, Choudhury R, Kernan J, Mills CA, Lahiri D, Burke DJ. Abstract A03: SCFCyclin F connects AKT signaling to the core cell cycle oscillator Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Cellcycle16-A03  0.421
2014 Ly T, Ahmad Y, Shlien A, Soroka D, Mills A, Emanuele MJ, Stratton MR, Lamond AI. A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells. Elife. 3: e01630. PMID 24596151 DOI: 10.7554/Elife.01630  0.351
2014 Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN. Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth. Cell Host & Microbe. 15: 113-24. PMID 24439903 DOI: 10.1016/J.Chom.2013.12.009  0.505
2014 Ly T, Ahmad Y, Shlien A, Soroka D, Mills A, Emanuele MJ, Stratton MR, Lamond AI. Author response: A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells Elife. DOI: 10.7554/Elife.01630.028  0.318
2012 Weng MT, Lee JH, Wei SC, Li Q, Shahamatdar S, Hsu D, Schetter AJ, Swatkoski S, Mannan P, Garfield S, Gucek M, Kim MK, Annunziata CM, Creighton CJ, Emanuele MJ, et al. Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 109: E3659-67. PMID 23236152 DOI: 10.1073/Pnas.1207673110  0.365
2012 Emanuele MJ, Elia AEH, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PWC, Yen HCS, Elledge SJ. Erratum: Global identification of modular cullin-ring ligase substrates (Cell (2011) 147 (459-475)) Cell. 148: 620-622. DOI: 10.1016/J.Cell.2012.01.028  0.694
2011 Emanuele MJ, Elia AEH, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PWC, Yen HCS, Elledge SJ. Global identification of modular cullin-RING ligase substrates Cell. 147: 459-474. PMID 21963094 DOI: 10.1016/J.Cell.2011.09.019  0.719
2011 Emanuele MJ, Ciccia A, Elia AEH, Elledge SJ. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate Proceedings of the National Academy of Sciences of the United States of America. 108: 9845-9850. PMID 21628590 DOI: 10.1073/Pnas.1106136108  0.586
2009 Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene Cell. 137: 835-848. PMID 19490893 DOI: 10.1016/J.Cell.2009.05.006  0.646
2009 Emanuele MJ, Stukenberg PT. Probing kinetochore structure and function using Xenopus laevis frog egg extracts. Methods in Molecular Biology (Clifton, N.J.). 545: 221-32. PMID 19475391 DOI: 10.1007/978-1-60327-993-2_13  0.649
2008 Emanuele MJ, Lan W, Jwa M, Miller SA, Chan CS, Stukenberg PT. Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. The Journal of Cell Biology. 181: 241-54. PMID 18426974 DOI: 10.1083/Jcb.200710019  0.706
2008 Vorozhko VV, Emanuele MJ, Kallio MJ, Stukenberg PT, Gorbsky GJ. Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin. Chromosoma. 117: 169-79. PMID 18057949 DOI: 10.1007/S00412-007-0135-3  0.647
2007 Emanuele MJ, Stukenberg PT. Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment. Cell. 130: 893-905. PMID 17803911 DOI: 10.1016/J.Cell.2007.07.023  0.664
2007 Emanuele M, Burke DJ, Stukenberg PT. A Hec of a microtubule attachment. Nature Structural & Molecular Biology. 14: 11-3. PMID 17203069 DOI: 10.1038/nsmb0107-11  0.58
2007 Gorbsky GJ, Kallio MJ, Emanuele MJ, Stukenberg PT, Vorozhko VV. Regulators of chromosome movement and the mitotic spindle checkpoint The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A209-E  0.614
2005 Emanuele MJ, McCleland ML, Satinover DL, Stukenberg PT. Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore. Molecular Biology of the Cell. 16: 4882-92. PMID 16079178 DOI: 10.1091/Mbc.E05-03-0239  0.711
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