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Todd J. Suscovich, Ph.D. - Publications

Affiliations: 
2005 Harvard University, Cambridge, MA, United States 
Area:
Microbiology Biology, Molecular Biology, Oncology
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 House RV, Broge TA, Suscovich TJ, Snow DM, Tomic MT, Nonet G, Bajwa K, Zhu G, Martinez Z, Hackett K, Earnhart CG, Dorsey NM, Hopkins SA, Natour DS, Davis HD, et al. Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics. Plos One. 17: e0267796. PMID 35657812 DOI: 10.1371/journal.pone.0267796  0.338
2021 Gunn BM, Lu R, Slein MD, Ilinykh PA, Huang K, Atyeo C, Schendel SL, Kim J, Cain C, Roy V, Suscovich TJ, Takada A, Halfmann PJ, Kawaoka Y, Pauthner MG, et al. A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus. Immunity. 54: 815-828.e5. PMID 33852832 DOI: 10.1016/j.immuni.2021.03.009  0.334
2021 Atyeo C, Slein MD, Fischinger S, Burke J, Schäfer A, Leist SR, Kuzmina NA, Mire C, Honko A, Johnson R, Storm N, Bernett M, Tong P, Zuo T, Lin J, ... ... Suscovich T, et al. Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022. Jci Insight. 6. PMID 33427208 DOI: 10.1172/jci.insight.143129  0.322
2020 Offersen R, Yu WH, Scully EP, Julg B, Euler Z, Sadanand S, Garcia-Dominguez D, Zheng L, Rasmussen TA, Jennewein MF, Linde C, Sassic J, Lofano G, Vigano S, Stephenson KE, ... ... Suscovich TJ, et al. HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound. Cell Reports. 33: 108502. PMID 33326789 DOI: 10.1016/j.celrep.2020.108502  0.327
2020 Das J, Devadhasan A, Linde C, Broge T, Sassic J, Mangano M, O'Keefe S, Suscovich T, Streeck H, Irrinki A, Pohlmeyer C, Min-Oo G, Lin S, Weiner JA, Cihlar T, et al. Mining for humoral correlates of HIV control and latent reservoir size. Plos Pathogens. 16: e1008868. PMID 33048992 DOI: 10.1371/journal.ppat.1008868  0.34
2020 Atyeo C, Fischinger S, Zohar T, Slein MD, Burke J, Loos C, McCulloch DJ, Newman KL, Wolf C, Yu J, Shuey K, Feldman J, Hauser BM, Caradonna T, Schmidt AG, ... Suscovich TJ, et al. Distinct Early Serological Signatures Track with SARS-CoV-2 Survival. Immunity. PMID 32783920 DOI: 10.1016/J.Immuni.2020.07.020  0.447
2020 Gilchuk P, Bombardi RG, Erasmus JH, Tan Q, Nargi R, Soto C, Abbink P, Suscovich TJ, Durnell LA, Khandhar A, Archer J, Liang J, Fouch ME, Davidson E, Doranz BJ, et al. Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics. Nature Biomedical Engineering. PMID 32747832 DOI: 10.1038/S41551-020-0594-X  0.307
2020 Suscovich TJ, Fallon JK, Das J, Demas AR, Crain J, Linde CH, Michell A, Natarajan H, Arevalo C, Broge T, Linnekin T, Kulkarni V, Lu R, Slein MD, Luedemann C, et al. Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination. Science Translational Medicine. 12. PMID 32718991 DOI: 10.1126/Scitranslmed.Abb4757  0.381
2019 Boudreau CM, Yu WH, Suscovich TJ, Talbot HK, Edwards KM, Alter G. Selective induction of antibody effector functional responses using MF59-adjuvanted vaccination. The Journal of Clinical Investigation. PMID 31845904 DOI: 10.1172/Jci129520  0.353
2019 Fischinger S, Fallon JK, Michell AR, Broge T, Suscovich TJ, Streeck H, Alter G. A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation. Journal of Immunological Methods. PMID 31301278 DOI: 10.1016/J.Jim.2019.07.002  0.403
2019 Gunn BM, Roy V, Karim MM, Hartnett JN, Suscovich TJ, Goba A, Momoh M, Sandi JD, Kanneh L, Andersen KG, Shaffer JG, Schieffelin JS, Garry RF, Grant DS, Alter G. Survivors of Ebola virus disease develop polyfunctional antibody responses. The Journal of Infectious Diseases. PMID 31301137 DOI: 10.1093/Infdis/Jiz364  0.363
2019 Jennewein MF, Goldfarb I, Dolatshahi S, Cosgrove C, Noelette FJ, Krykbaeva M, Das J, Sarkar A, Gorman MJ, Fischinger S, Boudreau CM, Brown J, Cooperrider JH, Aneja J, Suscovich TJ, et al. Fc Glycan-Mediated Regulation of Placental Antibody Transfer. Cell. PMID 31204102 DOI: 10.1016/J.Cell.2019.05.044  0.316
2019 Karsten CB, Mehta N, Shin SA, Diefenbach TJ, Slein MD, Karpinski W, Irvine EB, Broge T, Suscovich TJ, Alter G. A versatile high throughput assay to characterize antibody-mediated neutrophil phagocytosis. Journal of Immunological Methods. PMID 31132351 DOI: 10.1016/J.Jim.2019.05.006  0.338
2018 Ackerman ME, Das J, Pittala S, Broge T, Linde C, Suscovich TJ, Brown EP, Bradley T, Natarajan H, Lin S, Sassic JK, O'Keefe S, Mehta N, Goodman D, Sips M, et al. Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV. Nature Medicine. PMID 30177821 DOI: 10.1038/S41591-018-0161-0  0.436
2018 Lofano G, Gorman MJ, Yousif AS, Yu WH, Fox JM, Dugast AS, Ackerman ME, Suscovich TJ, Weiner J, Barouch D, Streeck H, Little S, Smith D, Richman D, Lauffenburger D, et al. Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement. Science Immunology. 3. PMID 30120121 DOI: 10.1126/Sciimmunol.Aat7796  0.392
2018 Gunn BM, Yu WH, Karim MM, Brannan JM, Herbert AS, Wec AZ, Halfmann PJ, Fusco ML, Schendel SL, Gangavarapu K, Krause T, Qiu X, He S, Das J, Suscovich TJ, et al. A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus. Cell Host & Microbe. 24: 221-233.e5. PMID 30092199 DOI: 10.1016/J.Chom.2018.07.009  0.393
2018 Yu WH, Zhao P, Draghi M, Arevalo C, Karsten CB, Suscovich TJ, Gunn B, Streeck H, Brass AL, Tiemeyer M, Seaman M, Mascola JR, Wells L, Lauffenburger DA, Alter G. Exploiting glycan topography for computational design of Env glycoprotein antigenicity. Plos Computational Biology. 14: e1006093. PMID 29677181 DOI: 10.1371/Journal.Pcbi.1006093  0.367
2018 Alter G, Dowell KG, Brown EP, Suscovich TJ, Mikhailova A, Mahan AE, Walker BD, Nimmerjahn F, Bailey-Kellogg C, Ackerman ME. High-resolution definition of humoral immune response correlates of effective immunity against HIV. Molecular Systems Biology. 14: e7881. PMID 29581149 DOI: 10.15252/Msb.20177881  0.414
2017 Sadanand S, Das J, Chung AW, Schoen MK, Lane S, Suscovich TJ, Streeck H, Smith D, Little S, Lauffenburger DA, Richman D, Alter G. Temporal variation in HIV-specific IgG subclass Abs during acute infection differentiates spontaneous controllers from chronic progressors. Aids (London, England). PMID 29239894 DOI: 10.1097/Qad.0000000000001716  0.309
2017 Lu LL, Suscovich TJ, Fortune SM, Alter G. Beyond binding: antibody effector functions in infectious diseases. Nature Reviews. Immunology. PMID 29063907 DOI: 10.1038/Nri.2017.106  0.359
2017 Bradley T, Pollara J, Santra S, Vandergrift N, Pittala S, Bailey-Kellogg C, Shen X, Parks R, Goodman D, Eaton A, Balachandran H, Mach LV, Saunders KO, Weiner JA, Scearce R, ... ... Suscovich TJ, et al. Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge. Nature Communications. 8: 15711. PMID 28593989 DOI: 10.1038/Ncomms15711  0.38
2017 Dugast AS, Arnold K, Lofano G, Moore S, Hoffner M, Simek M, Poignard P, Seaman M, Suscovich T, Pereyra F, Walker BD, Lauffenburger D, Kwon D, Keele BF, Alter G. Virus-driven inflammation is associated with the development of bNAbs in spontaneous controllers of HIV. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 28158448 DOI: 10.1093/Cid/Cix057  0.426
2016 Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, ... ... Suscovich TJ, et al. A Functional Role for Antibodies in Tuberculosis. Cell. PMID 27667685 DOI: 10.1016/J.Cell.2016.08.072  0.423
2016 Sips M, Liu Q, Draghi M, Ghebremichael M, Berger CT, Suscovich TJ, Sun Y, Walker BD, Carrington M, Altfeld M, Brouckaert P, De Jager PL, Alter G. HLA-C levels impact natural killer cell subset distribution and function. Human Immunology. PMID 27521484 DOI: 10.1016/J.Humimm.2016.08.004  0.34
2016 Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, et al. Correction: Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination. Plos Pathogens. 12: e1005694. PMID 27253391 DOI: 10.1371/Journal.Ppat.1005694  0.353
2016 Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, et al. Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination. Plos Pathogens. 12: e1005456. PMID 26982805 DOI: 10.1371/Journal.Ppat.1005456  0.356
2016 Gunn BM, Schneider JR, Shansab M, Bastian AR, Fahrbach KM, Smith AD, Mahan AE, Karim MM, Licht AF, Zvonar I, Tedesco J, Anderson MR, Chapel A, Suscovich TJ, Malaspina DC, et al. Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16. Mucosal Immunology. PMID 26960182 DOI: 10.1038/Mi.2016.8  0.378
2016 Ackerman ME, Mikhailova A, Brown EP, Dowell KG, Walker BD, Bailey-Kellogg C, Suscovich TJ, Alter G. Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control. Plos Pathogens. 12: e1005315. PMID 26745376 DOI: 10.1371/Journal.Ppat.1005315  0.376
2016 Sadanand S, Suscovich TJ, Alter G. Broadly Neutralizing Antibodies Against HIV: New Insights to Inform Vaccine Design. Annual Review of Medicine. 67: 185-200. PMID 26565674 DOI: 10.1146/Annurev-Med-091014-090749  0.467
2015 Choi I, Chung AW, Suscovich TJ, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, O'Connell RJ, Francis D, Robb ML, Michael NL, Kim JH, Alter G, Ackerman ME, Bailey-Kellogg C. Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees. Plos Computational Biology. 11: e1004185. PMID 25874406 DOI: 10.1371/Journal.Pcbi.1004185  0.469
2014 Dugast AS, Stamatatos L, Tonelli A, Suscovich TJ, Licht AF, Mikell I, Ackerman ME, Streeck H, Klasse PJ, Moore JP, Alter G. Independent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection. European Journal of Immunology. 44: 2925-37. PMID 25043633 DOI: 10.1002/Eji.201344305  0.41
2014 Dugast AS, Chan Y, Hoffner M, Licht A, Nkolola J, Li H, Streeck H, Suscovich TJ, Ghebremichael M, Ackerman ME, Barouch DH, Alter G. Lack of protection following passive transfer of polyclonal highly functional low-dose non-neutralizing antibodies. Plos One. 9: e97229. PMID 24820481 DOI: 10.1371/Journal.Pone.0097229  0.324
2014 van Teijlingen NH, Hölzemer A, Körner C, García-Beltrán WF, Schafer JL, Fadda L, Suscovich TJ, Brander C, Carrington M, Evans DT, van Baarle D, Altfeld M. Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03:04 and modulate primary natural killer cell function. Aids (London, England). 28: 1399-408. PMID 24785948 DOI: 10.1097/Qad.0000000000000284  0.396
2014 Chung AW, Ghebremichael M, Robinson H, Brown E, Choi I, Lane S, Dugast AS, Schoen MK, Rolland M, Suscovich TJ, Mahan AE, Liao L, Streeck H, Andrews C, Rerks-Ngarm S, et al. Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines. Science Translational Medicine. 6: 228ra38. PMID 24648341 DOI: 10.1126/Scitranslmed.3007736  0.365
2014 Lai JI, Licht AF, Dugast AS, Suscovich T, Choi I, Bailey-Kellogg C, Alter G, Ackerman ME. Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers. Journal of Virology. 88: 2799-809. PMID 24352471 DOI: 10.1128/Jvi.03130-13  0.423
2014 Dugast A, Chan Y, Hoffner M, Licht A, Nkolola J, Li H, Streeck H, Suscovich TJ, Ghebremichael M, Ackerman ME, Barouch DH, Alter G. Kinetics of gp41-specific antibody titers and contribution of Fc mediated gp41 specific antibody responses following SHIV-SF162P3 challenge. Plos One. DOI: 10.1371/Journal.Pone.0097229.G005  0.352
2013 Sciaranghella G, Tong N, Mahan AE, Suscovich TJ, Alter G. Decoupling activation and exhaustion of B cells in spontaneous controllers of HIV infection. Aids (London, England). 27: 175-80. PMID 23135171 DOI: 10.1097/Qad.0B013E32835Bd1F0  0.436
2011 Kamya P, Boulet S, Tsoukas CM, Routy JP, Thomas R, Côté P, Boulassel MR, Baril JG, Kovacs C, Migueles SA, Connors M, Suscovich TJ, Brander C, Tremblay CL, Bernard N, et al. Receptor-ligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1*h/*y and HLA-B*57. Journal of Virology. 85: 5949-60. PMID 21471235 DOI: 10.1128/Jvi.02652-10  0.301
2008 Yerly D, Heckerman D, Allen T, Suscovich TJ, Jojic N, Kadie C, Pichler WJ, Cerny A, Brander C. Design, expression, and processing of epitomized hepatitis C virus-encoded CTL epitopes. Journal of Immunology (Baltimore, Md. : 1950). 181: 6361-70. PMID 18941227 DOI: 10.4049/Jimmunol.181.9.6361  0.383
2008 Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, et al. Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. Journal of Virology. 82: 5594-605. PMID 18385228 DOI: 10.1128/Jvi.02356-07  0.388
2008 Meier A, Bagchi A, Sidhu HK, Alter G, Suscovich TJ, Kavanagh DG, Streeck H, Brockman MA, LeGall S, Hellman J, Altfeld M. Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands Aids. 22: 655-658. PMID 18317010 DOI: 10.1097/Qad.0B013E3282F4De23  0.327
2007 Alter G, Martin MP, Teigen N, Carr WH, Suscovich TJ, Schneidewind A, Streeck H, Waring M, Meier A, Brander C, Lifson JD, Allen TM, Carrington M, Altfeld M. Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. The Journal of Experimental Medicine. 204: 3027-36. PMID 18025129 DOI: 10.1084/Jem.20070695  0.499
2007 Frahm N, Yusim K, Suscovich TJ, Adams S, Sidney J, Hraber P, Hewitt HS, Linde CH, Kavanagh DG, Woodberry T, Henry LM, Faircloth K, Listgarten J, Kadie C, Jojic N, et al. Extensive HLA class I allele promiscuity among viral CTL epitopes. European Journal of Immunology. 37: 2419-33. PMID 17705138 DOI: 10.1002/Eji.200737365  0.389
2007 Alter G, Suscovich TJ, Teigen N, Meier A, Streeck H, Brander C, Altfeld M. Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 7658-66. PMID 17548602 DOI: 10.4049/Jimmunol.178.12.7658  0.449
2007 Bihl F, Narayan M, Chisholm JV, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C. Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes. Journal of Virology. 81: 4904-8. PMID 17329344 DOI: 10.1128/Jvi.02509-06  0.617
2006 Alter G, Suscovich TJ, Kleyman M, Teigen N, Streeck H, Zaman MT, Meier A, Altfeld M. Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection. Aids (London, England). 20: 1549-51. PMID 16847410 DOI: 10.1097/01.Aids.0000237371.31315.48  0.417
2005 Woodberry T, Suscovich TJ, Henry LM, Davis JK, Frahm N, Walker BD, Scadden DT, Wang F, Brander C. Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection. The Journal of Infectious Diseases. 192: 1513-24. PMID 16206065 DOI: 10.1086/491741  0.594
2005 Woodberry T, Suscovich TJ, Henry LM, August M, Waring MT, Kaur A, Hess C, Kutok JL, Aster JC, Wang F, Scadden DT, Brander C. Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population. Journal of Immunology (Baltimore, Md. : 1950). 175: 4355-62. PMID 16177076 DOI: 10.4049/Jimmunol.175.7.4355  0.563
2005 Woodberry T, Suscovich TJ, Henry LM, Martin JN, Dollard S, O'Connor PG, Davis JK, Osmond D, Lee TH, Kedes DH, Khatri A, Lee J, Walker BD, Scadden DT, Brander C. Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins. The Journal of Infectious Diseases. 192: 622-9. PMID 16028131 DOI: 10.1086/432103  0.609
2005 Alter G, Teigen N, Davis BT, Addo MM, Suscovich TJ, Waring MT, Streeck H, Johnston MN, Staller KD, Zaman MT, Yu XG, Lichterfeld M, Basgoz N, Rosenberg ES, Altfeld M. Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood. 106: 3366-9. PMID 16002429 DOI: 10.1182/Blood-2005-03-1100  0.424
2005 Bihl FK, Loggi E, Chisholm JV, Hewitt HS, Henry LM, Linde C, Suscovich TJ, Wong JT, Frahm N, Andreone P, Brander C. Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti- CD3 mAb T-cell expansion and "RecycleSpot" Journal of Translational Medicine. 3: 20. PMID 15888204 DOI: 10.1186/1479-5876-3-20  0.531
2004 Suscovich TJ, Paulose-Murphy M, Harlow JD, Chen Y, Thomas SY, Mellott TJ, Walker BD, Scadden DT, Zeichner S, Brander C. Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles. Leukemia & Lymphoma. 45: 1223-38. PMID 15360006 DOI: 10.1080/10428190310001643358  0.599
2004 SenGupta D, Norris PJ, Suscovich TJ, Hassan-Zahraee M, Moffett HF, Trocha A, Draenert R, Goulder PJ, Binder RJ, Levey DL, Walker BD, Srivastava PK, Brander C. Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II. Journal of Immunology (Baltimore, Md. : 1950). 173: 1987-93. PMID 15265933 DOI: 10.4049/Jimmunol.173.3.1987  0.46
2001 Brander C, O'Connor P, Suscovich T, Jones NG, Lee Y, Kedes D, Ganem D, Martin J, Osmond D, Southwood S, Sette A, Walker BD, Scadden DT. Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein. The Journal of Infectious Diseases. 184: 119-26. PMID 11424007 DOI: 10.1086/322003  0.602
2000 Brander C, Suscovich T, Lee Y, Nguyen PT, O'Connor P, Seebach J, Jones NG, van Gorder M, Walker BD, Scadden DT. Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus. Journal of Immunology (Baltimore, Md. : 1950). 165: 2077-83. PMID 10925292 DOI: 10.4049/Jimmunol.165.4.2077  0.586
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