Sarah M. Fortune - Publications

Affiliations: 
Biology: Medical Sciences, Division of Harvard University, Cambridge, MA, United States 
Area:
Microbiology Biology

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Simonson AW, Zeppa JJ, Bucsan AN, Chao MC, Pokkali S, Hopkins F, Chase MR, Vickers AJ, Sutton MS, Winchell CG, Myers AJ, Ameel CL, Kelly R, Krouse B, Hood LE, ... ... Fortune S, et al. CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques. Biorxiv : the Preprint Server For Biology. PMID 38798646 DOI: 10.1101/2024.05.14.594183  0.516
2024 Stanley S, Spaulding CN, Liu Q, Chase MR, Ha DTM, Thai PVK, Lan NH, Thu DDA, Quang NL, Brown J, Hicks ND, Wang X, Marin M, Howard NC, Vickers AJ, ... ... Fortune SM, et al. Identification of bacterial determinants of tuberculosis infection and treatment outcomes: a phenogenomic analysis of clinical strains. The Lancet. Microbe. PMID 38734030 DOI: 10.1016/S2666-5247(24)00022-3  0.536
2024 Bei C, Zhu J, Culviner PH, Gan M, Rubin EJ, Fortune SM, Gao Q, Liu Q. Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis. Nature Communications. 15: 3088. PMID 38600064 DOI: 10.1038/s41467-024-47410-5  0.438
2024 Ganchua SK, Maiello P, Chao M, Hopkins F, Mugahid D, Lin PL, Fortune SM, Flynn JL. Antibiotic treatment modestly reduces protection against reinfection in macaques. Infection and Immunity. e0053523. PMID 38514467 DOI: 10.1128/iai.00535-23  0.518
2023 Ganchua SK, Maiello P, Chao M, Hopkins F, Mugahid D, Lin PL, Fortune SM, Flynn JL. Antibiotic treatment does not abrogate protection against Mycobacterium tuberculosis reinfection in Macaques. Biorxiv : the Preprint Server For Biology. PMID 38187678 DOI: 10.1101/2023.12.19.570845  0.527
2023 Bromley JD, Ganchua SKC, Nyquist SK, Maiello P, Chao M, Borish HJ, Rodgers M, Tomko J, Kracinovsky K, Mugahid D, Nguyen S, Wang D, Rosenberg JM, Klein EC, Gideon HP, ... ... Fortune SM, et al. CD4 T cells are homeostatic regulators during reinfection. Biorxiv : the Preprint Server For Biology. PMID 38187598 DOI: 10.1101/2023.12.20.572669  0.481
2023 Wang X, Su H, Wallach JB, Wagner JC, Braunecker B, Gardner M, Guinn KM, Klevorn T, Lin K, Liu YJ, Liu Y, Mugahid D, Rodgers M, Sixsmith J, Wakabayashi S, ... ... Fortune SM, et al. Development of an Engineered Strain for a Safe and Effective Tuberculosis Human Challenge Model. Biorxiv : the Preprint Server For Biology. PMID 38014062 DOI: 10.1101/2023.11.19.567569  0.419
2023 Winchell CG, Nyquist SK, Chao MC, Maiello P, Myers AJ, Hopkins F, Chase M, Gideon HP, Patel KV, Bromley JD, Simonson AW, Floyd-O'Sullivan R, Wadsworth M, Rosenberg JM, Uddin R, ... ... Fortune SM, et al. CD8+ lymphocytes are critical for early control of tuberculosis in macaques. The Journal of Experimental Medicine. 220. PMID 37843832 DOI: 10.1084/jem.20230707  0.481
2023 Bei C, Zhu J, Culviner PH, Rubin EJ, Fortune SM, Gao Q, Liu Q. Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis. Research Square. PMID 37790329 DOI: 10.21203/rs.3.rs-3303807/v1  0.412
2023 Bei C, Zhu J, Culviner PH, Rubin EJ, Fortune SM, Gao Q, Liu Q. Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis. Biorxiv : the Preprint Server For Biology. PMID 37645742 DOI: 10.1101/2023.08.20.553992  0.412
2023 Stanley S, Spaulding CN, Liu Q, Chase MR, Ha DTM, Thai PVK, Lan NH, Thu DDA, Quang NL, Brown J, Hicks ND, Wang X, Marin M, Howard NC, Vickers AJ, ... ... Fortune SM, et al. High-throughput phenogenotyping clinical strains reveals bacterial determinants of treatment outcomes. Biorxiv : the Preprint Server For Biology. PMID 37090677 DOI: 10.1101/2023.04.09.536166  0.494
2022 Liu Q, Zhu J, Dulberger CL, Stanley S, Wilson S, Chung ES, Wang X, Culviner P, Liu YJ, Hicks ND, Babunovic GH, Giffen SR, Aldridge BB, Garner EC, Rubin EJ, ... ... Fortune SM, et al. Tuberculosis treatment failure associated with evolution of antibiotic resilience. Science (New York, N.Y.). 378: 1111-1118. PMID 36480634 DOI: 10.1126/science.abq2787  0.604
2022 Freeman AH, Tembiwa K, Brenner JR, Chase MR, Fortune SM, Morita YS, Boutte CC. Arginine methylation sites on SepIVA help balance elongation and septation in Mycobacterium smegmatis. Molecular Microbiology. PMID 36416406 DOI: 10.1111/mmi.15006  0.659
2022 Tomasi FG, Hall AMJ, Schweber JTP, Dulberger CL, McGowen K, Liu Q, Fortune SM, Helaine S, Rubin EJ. A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis. Microbiology Spectrum. e0058022. PMID 35638832 DOI: 10.1128/spectrum.00580-22  0.5
2022 Gideon HP, Hughes TK, Tzouanas CN, Wadsworth MH, Tu AA, Gierahn TM, Peters JM, Hopkins FF, Wei JR, Kummerlowe C, Grant NL, Nargan K, Phuah JY, Borish HJ, Maiello P, ... ... Fortune SM, et al. Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control. Immunity. PMID 35483355 DOI: 10.1016/j.immuni.2022.04.004  0.552
2022 Babunovic GH, DeJesus MA, Bosch B, Chase MR, Barbier T, Dickey AK, Bryson BD, Rock JM, Fortune SM. CRISPR Interference Reveals That All--Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A. Mbio. e0368321. PMID 35038923 DOI: 10.1128/mbio.03683-21  0.339
2021 Zhu J, Wolf ID, Dulberger CL, Won HI, Kester JC, Judd JA, Wirth SE, Clark RR, Li Y, Luo Y, Gray TA, Wade JT, Derbyshire KM, Fortune SM, Rubin EJ. Spatiotemporal localization of proteins in mycobacteria. Cell Reports. 37: 110154. PMID 34965429 DOI: 10.1016/j.celrep.2021.110154  0.416
2020 Hicks ND, Giffen SR, Culviner PH, Chao MC, Dulberger CL, Liu Q, Stanley S, Brown J, Sixsmith J, Wolf ID, Fortune SM. Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis. Plos Pathogens. 16: e1009063. PMID 33253310 DOI: 10.1371/journal.ppat.1009063  0.542
2020 Kester JC, Kandror O, Akopian T, Chase MR, Zhu J, Rubin EJ, Goldberg AL, Fortune SM. ClpX is Essential and Activated by Single Strand DNA Binding Protein in Mycobacteria. Journal of Bacteriology. PMID 33229461 DOI: 10.1128/JB.00608-20  0.402
2020 Sutiwisesak R, Hicks ND, Boyce S, Murphy KC, Papavinasasundaram K, Carpenter SM, Boucau J, Joshi N, Le Gall S, Fortune SM, Sassetti CM, Behar SM. A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response. Plos Pathogens. 16: e1009000. PMID 33075106 DOI: 10.1371/journal.ppat.1009000  0.585
2020 Lai Y, Babunovic GH, Cui L, Dedon PC, Doench JG, Fortune SM, Lu TK. Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens. Cell Systems. 11: 239-251.e7. PMID 32970993 DOI: 10.1016/j.cels.2020.08.010  0.31
2020 Diedrich CR, Rutledge T, Maiello P, Baranowski TM, White AG, Borish HJ, Karell P, Hopkins F, Brown J, Fortune SM, Flynn JL, Ambrose Z, Lin PL. SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis. Plos Pathogens. 16: e1008413. PMID 32730321 DOI: 10.1371/Journal.Ppat.1008413  0.367
2020 Liu Q, Wei J, Li Y, Wang M, Su J, Lu Y, López MG, Qian X, Zhu Z, Wang H, Gan M, Jiang Q, Fu YX, Takiff HE, Comas I, ... ... Fortune SM, et al. clinical isolates carry mutational signatures of host immune environments. Science Advances. 6: eaba4901. PMID 32524000 DOI: 10.1126/Sciadv.Aba4901  0.363
2020 Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, ... ... Fortune SM, et al. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. PMID 32413319 DOI: 10.1016/J.Cell.2020.04.035  0.346
2020 Bekeredjian-Ding I, Van Molle W, Baay M, Neels P, Conrad C, van Diepen A, Fortune S, Goetz K, Gorringe A, Hoft D, Johnson RA, Kremsner P, Krut O, Levy Y, et al. Human challenge trial workshop: Focus on quality requirements for challenge agents, Langen, Germany, October 22, 2019. Biologicals : Journal of the International Association of Biological Standardization. PMID 32389512 DOI: 10.1016/J.Biologicals.2020.04.005  0.317
2020 Lu LL, Das J, Grace PS, Fortune SM, Restrepo BI, Alter G. Antibody Fc Glycosylation Discriminates Between Latent and Active Tuberculosis. The Journal of Infectious Diseases. PMID 32060529 DOI: 10.1093/Infdis/Jiz643  0.36
2019 Tang S, Hicks ND, Cheng YS, Silva A, Fortune SM, Sacchettini JC. Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Research. PMID 31504787 DOI: 10.1093/Nar/Gkz724  0.317
2019 Bryson BD, Rosebrock TR, Tafesse FG, Itoh CY, Nibasumba A, Babunovic GH, Corleis B, Martin C, Keegan C, Andrade P, Realegeno S, Kwon D, Modlin RL, Fortune SM. Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis. Nature Communications. 10: 2329. PMID 31133636 DOI: 10.1038/S41467-019-10065-8  0.374
2019 Lu LL, Smith MT, Yu KKQ, Luedemann C, Suscovich TJ, Grace PS, Cain A, Yu WH, McKitrick TR, Lauffenburger D, Cummings RD, Mayanja-Kizza H, Hawn TR, Boom WH, Stein CM, ... Fortune SM, et al. IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure. Nature Medicine. PMID 31110348 DOI: 10.1038/S41591-019-0441-3  0.393
2019 Hicks ND, Carey AF, Yang J, Zhao Y, Fortune SM. Bacterial Genome-Wide Association Identifies Novel Factors That Contribute to Ethionamide and Prothionamide Susceptibility in Mycobacterium tuberculosis. Mbio. 10. PMID 31015328 DOI: 10.1128/Mbio.00616-19  0.372
2019 Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, et al. Definitions and guidelines for research on antibiotic persistence. Nature Reviews. Microbiology. PMID 30980069 DOI: 10.1038/S41579-019-0196-3  0.33
2019 Montoya DJ, Andrade P, Silva BJA, Teles RMB, Ma F, Bryson B, Sadanand S, Noel T, Lu J, Sarno E, Arnvig KB, Young D, Lahiri R, Williams DL, Fortune S, et al. Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response. Cell Reports. 26: 3574-3585.e3. PMID 30917313 DOI: 10.1016/J.Celrep.2019.02.109  0.366
2019 Farhat MR, Sixsmith J, Calderon R, Hicks ND, Fortune SM, Murray M. Rifampicin and rifabutin resistance in 1003 Mycobacterium tuberculosis clinical isolates. The Journal of Antimicrobial Chemotherapy. PMID 30793747 DOI: 10.1093/Jac/Dkz048  0.337
2018 Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL. Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques. Plos Pathogens. 14: e1007305. PMID 30312351 DOI: 10.1371/Journal.Ppat.1007305  0.383
2018 Hicks ND, Yang J, Zhang X, Zhao B, Grad YH, Liu L, Ou X, Chang Z, Xia H, Zhou Y, Wang S, Dong J, Sun L, Zhu Y, Zhao Y, ... ... Fortune SM, et al. Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance. Nature Microbiology. PMID 30082724 DOI: 10.1038/S41564-018-0218-3  0.373
2018 Simmons JD, Stein CM, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis RS, Churchyard G, Mayanja-Kizza H, Boom WH, Hawn TR. Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nature Reviews. Immunology. PMID 29895826 DOI: 10.1038/S41577-018-0025-3  0.413
2018 Gerrick ER, Barbier T, Chase MR, Xu R, François J, Lin VH, Szucs MJ, Rock JM, Ahmad R, Tjaden B, Livny J, Fortune SM. Small RNA profiling in identifies MrsI as necessary for an anticipatory iron sparing response. Proceedings of the National Academy of Sciences of the United States of America. PMID 29871950 DOI: 10.1073/Pnas.1718003115  0.311
2018 Yang JD, Mott D, Sutiwisesak R, Lu YJ, Raso F, Stowell B, Babunovic GH, Lee J, Carpenter SM, Way SS, Fortune SM, Behar SM. Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages. Plos Pathogens. 14: e1007060. PMID 29782535 DOI: 10.1371/Journal.Ppat.1007060  0.363
2018 Sakatos A, Babunovic GH, Chase MR, Dills A, Leszyk J, Rosebrock T, Bryson B, Fortune SM. Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria. Science Advances. 4: eaao1478. PMID 29732401 DOI: 10.1126/Sciadv.Aao1478  0.364
2018 Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM. TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities. Plos Pathogens. 14: e1006939. PMID 29505613 DOI: 10.1371/Journal.Ppat.1006939  0.344
2018 Rubin EJ, Fortune SM. Misunderstanding the goals of animal research. Bmj (Clinical Research Ed.). 360: k759. PMID 29467126 DOI: 10.1136/Bmj.K759  0.39
2017 Franchina FA, Mellors TR, Aliyeva M, Wagner J, Daphtary N, Lundblad L, Fortune SM, Rubin EJ, Hill JE. Towards the use of breath for detecting mycobacterial infection: a case study in a Murine model. Journal of Breath Research. PMID 29219122 DOI: 10.1088/1752-7163/Aaa016  0.471
2017 Warner DF, Rock JM, Fortune SM, Mizrahi V. DNA Replication Fidelity in the Mycobacterium tuberculosis Complex. Advances in Experimental Medicine and Biology. 1019: 247-262. PMID 29116639 DOI: 10.1007/978-3-319-64371-7_13  0.411
2017 Lu LL, Suscovich TJ, Fortune SM, Alter G. Beyond binding: antibody effector functions in infectious diseases. Nature Reviews. Immunology. PMID 29063907 DOI: 10.1038/Nri.2017.106  0.317
2017 Kurthkoti K, Amin H, Marakalala MJ, Ghanny S, Subbian S, Sakatos A, Livny J, Fortune SM, Berney M, Rodriguez GM. The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas. Mbio. 8. PMID 28811344 DOI: 10.1128/Mbio.01092-17  0.371
2017 Cadena AM, Fortune SM, Flynn JL. Heterogeneity in tuberculosis. Nature Reviews. Immunology. PMID 28736436 DOI: 10.1038/Nri.2017.69  0.409
2017 Martin CJ, Cadena AM, Leung VW, Lin PL, Maiello P, Hicks N, Chase MR, Flynn JL, Fortune SM. Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis. Mbio. 8. PMID 28487426 DOI: 10.1128/Mbio.00312-17  0.402
2017 Gierahn TM, Wadsworth MH, Hughes TK, Bryson BD, Butler A, Satija R, Fortune S, Love JC, Shalek AK. Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput. Nature Methods. PMID 28192419 DOI: 10.1038/Nmeth.4179  0.308
2017 Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nature Microbiology. 2: 16274. PMID 28165460 DOI: 10.1038/Nmicrobiol.2016.274  0.692
2017 DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mbio. 8. PMID 28096490 DOI: 10.1128/Mbio.02133-16  0.776
2016 Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, ... ... Fortune SM, et al. A Functional Role for Antibodies in Tuberculosis. Cell. PMID 27667685 DOI: 10.1016/J.Cell.2016.08.072  0.407
2016 Kaufmann SH, Fortune S, Pepponi I, Ruhwald M, Schrager L, Ottenhoff TH. TB biomarkers, TB correlates and human challenge models: New tools for improving assessment of new TB vaccines. Tuberculosis (Edinburgh, Scotland). PMID 27402312 DOI: 10.1016/J.Tube.2016.05.010  0.329
2016 Lin PL, Maiello P, Gideon HP, Coleman MT, Cadena AM, Rodgers MA, Gregg R, O'Malley M, Tomko J, Fillmore D, Frye LJ, Rutledge T, DiFazio RM, Janssen C, Klein E, ... ... Fortune SM, et al. PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis. Plos Pathogens. 12: e1005739. PMID 27379816 DOI: 10.1371/Journal.Ppat.1005739  0.326
2016 Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. Elife. 5. PMID 27304077 DOI: 10.7554/Elife.14590  0.794
2016 Lahiri N, Shah RR, Layre E, Young D, Ford C, Murray MB, Fortune SM, Moody DB. Rifampin Resistance Mutations are Associated with Broad Chemical Remodeling of Mycobacterium tuberculosis. The Journal of Biological Chemistry. PMID 27226566 DOI: 10.1074/Jbc.M116.716704  0.692
2016 Cadena AM, Flynn JL, Fortune SM. The Importance of First Impressions: Early Events in Mycobacterium tuberculosis Infection Influence Outcome. Mbio. 7. PMID 27048801 DOI: 10.1128/Mbio.00342-16  0.371
2016 Grad YH, Fortune SM. Biodiversity and hypervirulence of Listeria monocytogenes. Nature Genetics. 48: 229-30. PMID 26906682 DOI: 10.1038/Ng.3515  0.309
2016 Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. Author response: A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis Elife. DOI: 10.7554/Elife.14590.018  0.763
2015 Martin CJ, Carey AF, Fortune SM. A bug's life in the granuloma. Seminars in Immunopathology. PMID 26577238 DOI: 10.1007/S00281-015-0533-1  0.373
2015 Shell SS, Wang J, Lapierre P, Mir M, Chase MR, Pyle MM, Gawande R, Ahmad R, Sarracino DA, Ioerger TR, Fortune SM, Derbyshire KM, Wade JT, Gray TA. Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape. Plos Genetics. 11: e1005641. PMID 26536359 DOI: 10.1371/Journal.Pgen.1005641  0.331
2015 Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. Plos Pathogens. 11: e1005010. PMID 26114871 DOI: 10.1371/Journal.Ppat.1005010  0.749
2015 Datta P, Ravi J, Guerrini V, Chauhan R, Neiditch MB, Shell SS, Fortune SM, Hancioglu B, Igoshin OA, Gennaro ML. The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions. Molecular Microbiology. PMID 25899163 DOI: 10.1111/Mmi.13037  0.367
2015 Rock JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R, Coscolla M, Gagneux S, Fortune SM, Lamers MH. DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader. Nature Genetics. 47: 677-81. PMID 25894501 DOI: 10.1038/Ng.3269  0.69
2015 Gideon HP, Phuah J, Myers AJ, Bryson BD, Rodgers MA, Coleman MT, Maiello P, Rutledge T, Marino S, Fortune SM, Kirschner DE, Lin PL, Flynn JL. Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization. Plos Pathogens. 11: e1004603. PMID 25611466 DOI: 10.1371/Journal.Ppat.1004603  0.355
2015 Ramsdell TL, Huppert LA, Sysoeva TA, Fortune SM, Burton BM. Linked domain architectures allow for specialization of function in the FtsK/SpoIIIE ATPases of ESX secretion systems. Journal of Molecular Biology. 427: 1119-32. PMID 24979678 DOI: 10.1016/J.Jmb.2014.06.013  0.757
2015 Rock JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R, Coscolla M, Gagneux S, Fortune SM, Lamers MH. DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader Nature Genetics. 47: 677-681. DOI: 10.1038/ng.3269  0.654
2014 Aldridge BB, Keren I, Fortune SM. The Spectrum of Drug Susceptibility in Mycobacteria. Microbiology Spectrum. 2. PMID 26104360 DOI: 10.1128/Microbiolspec.Mgm2-0031-2013  0.391
2014 Huppert LA, Ramsdell TL, Chase MR, Sarracino DA, Fortune SM, Burton BM. The ESX system in Bacillus subtilis mediates protein secretion. Plos One. 9: e96267. PMID 24798022 DOI: 10.1371/Journal.Pone.0096267  0.764
2014 Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB. Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c. Proceedings of the National Academy of Sciences of the United States of America. 111: 2978-83. PMID 24516143 DOI: 10.1073/Pnas.1315883111  0.557
2014 Lin PL, Ford CB, Coleman MT, Myers AJ, Gawande R, Ioerger T, Sacchettini J, Fortune SM, Flynn JL. Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing. Nature Medicine. 20: 75-9. PMID 24336248 DOI: 10.1038/Nm.3412  0.694
2014 Kester JC, Fortune SM. Persisters and beyond: mechanisms of phenotypic drug resistance and drug tolerance in bacteria. Critical Reviews in Biochemistry and Molecular Biology. 49: 91-101. PMID 24328927 DOI: 10.3109/10409238.2013.869543  0.311
2013 Shell SS, Prestwich EG, Baek SH, Shah RR, Sassetti CM, Dedon PC, Fortune SM. DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. Plos Pathogens. 9: e1003419. PMID 23853579 DOI: 10.1371/Journal.Ppat.1003419  0.634
2013 Ford CB, Shah RR, Maeda MK, Gagneux S, Murray MB, Cohen T, Johnston JC, Gardy J, Lipsitch M, Fortune SM. Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis. Nature Genetics. 45: 784-90. PMID 23749189 DOI: 10.1038/Ng.2656  0.702
2013 Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C, Shah RR, Ahmad R, Fernandez-Suarez M, Fortune SM, Toner M, Lee H, Weissleder R. Magnetic barcode assay for genetic detection of pathogens. Nature Communications. 4: 1752. PMID 23612293 DOI: 10.1038/Ncomms2745  0.682
2013 Ragheb MN, Ford CB, Chase MR, Lin PL, Flynn JL, Fortune SM. The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection. Bmc Genomics. 14: 145. PMID 23496945 DOI: 10.1186/1471-2164-14-145  0.698
2013 Chao MC, Kieser KJ, Minami S, Mavrici D, Aldridge BB, Fortune SM, Alber T, Rubin EJ. Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria. Plos Pathogens. 9: e1003197. PMID 23468634 DOI: 10.1371/Journal.Ppat.1003197  0.784
2012 De Leon J, Jiang G, Ma Y, Rubin E, Fortune S, Sun J. Mycobacterium tuberculosis ESAT-6 exhibits a unique membrane-interacting activity that is not found in its ortholog from non-pathogenic Mycobacterium smegmatis. The Journal of Biological Chemistry. 287: 44184-91. PMID 23150662 DOI: 10.1074/Jbc.M112.420869  0.471
2012 Fortune SM. The surprising diversity of Mycobacterium tuberculosis: change you can believe in. The Journal of Infectious Diseases. 206: 1642-4. PMID 22984117 DOI: 10.1093/Infdis/Jis603  0.366
2012 Martin CJ, Booty MG, Rosebrock TR, Nunes-Alves C, Desjardins DM, Keren I, Fortune SM, Remold HG, Behar SM. Efferocytosis is an innate antibacterial mechanism. Cell Host & Microbe. 12: 289-300. PMID 22980326 DOI: 10.1016/J.Chom.2012.06.010  0.414
2012 Lee HJ, Lang PT, Fortune SM, Sassetti CM, Alber T. Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis. Nature Structural & Molecular Biology. 19: 811-8. PMID 22773105 DOI: 10.1038/Nsmb.2318  0.633
2012 Wirth SE, Krywy JA, Aldridge BB, Fortune SM, Fernandez-Suarez M, Gray TA, Derbyshire KM. Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria. Molecular Microbiology. 83: 654-64. PMID 22233444 DOI: 10.1111/J.1365-2958.2011.07958.X  0.374
2012 Ford C, Yusim K, Ioerger T, Feng S, Chase M, Greene M, Korber B, Fortune S. Mycobacterium tuberculosis - Heterogeneity revealed through whole genome sequencing Tuberculosis. 92: 194-201. PMID 22218163 DOI: 10.1016/J.Tube.2011.11.003  0.677
2012 Aldridge BB, Fernandez-Suarez M, Heller D, Ambravaneswaran V, Irimia D, Toner M, Fortune SM. Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science (New York, N.Y.). 335: 100-4. PMID 22174129 DOI: 10.1126/Science.1216166  0.333
2011 Sillé FC, Martin C, Jayaraman P, Rothchild A, Fortune S, Besra GS, Behar SM, Boes M. Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation. Infection and Immunity. 79: 3053-63. PMID 21576321 DOI: 10.1128/Iai.01108-10  0.419
2011 Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, Flynn JL, Fortune SM. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nature Genetics. 43: 482-6. PMID 21516081 DOI: 10.1038/Ng.811  0.692
2011 Millington KA, Fortune SM, Low J, Garces A, Hingley-Wilson SM, Wickremasinghe M, Kon OM, Lalvani A. Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection. Proceedings of the National Academy of Sciences of the United States of America. 108: 5730-5. PMID 21427227 DOI: 10.1073/Pnas.1015153108  0.429
2011 Woodworth JS, Shin D, Volman M, Nunes-Alves C, Fortune SM, Behar SM. Mycobacterium tuberculosis directs immunofocusing of CD8+ T cell responses despite vaccination. Journal of Immunology (Baltimore, Md. : 1950). 186: 1627-37. PMID 21178003 DOI: 10.4049/Jimmunol.1002911  0.363
2010 Fortune SM, Rubin EJ. Host transcription in active and latent tuberculosis. Genome Biology. 11: 135. PMID 20920149 DOI: 10.1186/Gb-2010-11-9-135  0.525
2010 Garces A, Atmakuri K, Chase MR, Woodworth JS, Krastins B, Rothchild AC, Ramsdell TL, Lopez MF, Behar SM, Sarracino DA, Fortune SM. EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity. Plos Pathogens. 6: e1000957. PMID 20585630 DOI: 10.1371/Journal.Ppat.1000957  0.78
2010 Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. Journal of Bacteriology. 192: 3645-53. PMID 20472797 DOI: 10.1128/Jb.00166-10  0.659
2009 Bitter W, Houben EN, Bottai D, Brodin P, Brown EJ, Cox JS, Derbyshire K, Fortune SM, Gao LY, Liu J, Gey van Pittius NC, Pym AS, Rubin EJ, Sherman DR, Cole ST, et al. Systematic genetic nomenclature for type VII secretion systems. Plos Pathogens. 5: e1000507. PMID 19876390 DOI: 10.1371/Journal.Ppat.1000507  0.403
2009 Siegrist MS, Unnikrishnan M, McConnell MJ, Borowsky M, Cheng TY, Siddiqi N, Fortune SM, Moody DB, Rubin EJ. Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition. Proceedings of the National Academy of Sciences of the United States of America. 106: 18792-7. PMID 19846780 DOI: 10.1073/Pnas.0900589106  0.603
2009 Pandey AK, Yang Y, Jiang Z, Fortune SM, Coulombe F, Behr MA, Fitzgerald KA, Sassetti CM, Kelliher MA. NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. Plos Pathogens. 5: e1000500. PMID 19578435 DOI: 10.1371/Journal.Ppat.1000500  0.659
2009 Divangahi M, Chen M, Gan H, Desjardins D, Hickman TT, Lee DM, Fortune S, Behar SM, Remold HG. Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair. Nature Immunology. 10: 899-906. PMID 19561612 DOI: 10.1038/Ni.1758  0.324
2008 Atmakuri K, Fortune SM. Regulation of protein secretion by ... protein secretion? Cell Host & Microbe. 4: 190-1. PMID 18779042 DOI: 10.1016/J.Chom.2008.08.009  0.388
2008 Woodworth JS, Fortune SM, Behar SM. Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10. Infection and Immunity. 76: 4199-205. PMID 18591224 DOI: 10.1128/Iai.00307-08  0.379
2007 Fortune SM, Rubin EJ. The complex relationship between mycobacteria and macrophages: it's not all bliss. Cell Host & Microbe. 2: 5-6. PMID 18005712 DOI: 10.1016/J.Chom.2007.06.008  0.452
2007 Hett EC, Chao MC, Steyn AJ, Fortune SM, Deng LL, Rubin EJ. A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis. Molecular Microbiology. 66: 658-68. PMID 17919286 DOI: 10.1111/J.1365-2958.2007.05945.X  0.797
2006 Joshi SM, Pandey AK, Capite N, Fortune SM, Rubin EJ, Sassetti CM. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proceedings of the National Academy of Sciences of the United States of America. 103: 11760-5. PMID 16868085 DOI: 10.1073/Pnas.0603179103  0.68
2006 Fortune SM, Chase MR, Rubin EJ. Dividing oceans into pools: strategies for the global analysis of bacterial genes. Microbes and Infection / Institut Pasteur. 8: 1631-6. PMID 16697239 DOI: 10.1016/J.Micinf.2005.11.015  0.471
2005 Fortune SM, Jaeger A, Sarracino DA, Chase MR, Sassetti CM, Sherman DR, Bloom BR, Rubin EJ. Mutually dependent secretion of proteins required for mycobacterial virulence. Proceedings of the National Academy of Sciences of the United States of America. 102: 10676-81. PMID 16030141 DOI: 10.1073/Pnas.0504922102  0.685
2004 Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, Ernst JD. Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms. Journal of Immunology (Baltimore, Md. : 1950). 172: 6272-80. PMID 15128816 DOI: 10.4049/Jimmunol.172.10.6272  0.514
2003 Wain J, Diem Nga LT, Kidgell C, James K, Fortune S, Song Diep T, Ali T, O Gaora P, Parry C, Parkhill J, Farrar J, White NJ, Dougan G. Molecular analysis of incHI1 antimicrobial resistance plasmids from Salmonella serovar Typhi strains associated with typhoid fever. Antimicrobial Agents and Chemotherapy. 47: 2732-9. PMID 12936967 DOI: 10.1128/Aac.47.9.2732-2739.2003  0.301
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