| Year |
Citation |
Score |
| 2024 |
Jacobson KA, IJzerman AP, Linden J. 1,3-Dialkylxanthine Derivatives Having High Potency as Antagonists at Human A Adenosine Receptors. Drug Development Research. 47: 45-53. PMID 38239816 DOI: 10.1002/(sici)1098-2299(199905)47:1<45::aid-ddr6>3.0.co;2-u |
0.31 |
|
| 2022 |
Kim YC, Karton Y, Ji XD, Melman N, Linden J, Jacobson KA. Acyl-Hydrazide Derivatives of a Xanthine Carboxylic Congener (XCC) as Selective Antagonists at Human A Adenosine Receptors. Drug Development Research. 47: 178-188. PMID 35790094 DOI: 10.1002/(sici)1098-2299(199908)47:4<178::aid-ddr4>3.0.co;2-l |
0.303 |
|
| 2020 |
Chen S, Akdemir I, Fan J, Linden J, Zhang B, Cekic C. The Expression of Adenosine A2B Receptor on Antigen Presenting Cells Suppresses CD8+ T cell Responses and Promotes Tumor Growth. Cancer Immunology Research. PMID 32381524 DOI: 10.1158/2326-6066.Cir-19-0833 |
0.345 |
|
| 2018 |
Yu JC, Lin G, Field JJ, Linden J. Induction of antiinflammatory purinergic signaling in activated human iNKT cells. Jci Insight. 3. PMID 30185656 DOI: 10.1172/Jci.Insight.91954 |
0.383 |
|
| 2017 |
Young A, Ngiow SF, Gao Y, Patch AM, Barkauskas DS, Messaoudene M, Lin G, Coudert JD, Stannard KA, Zitvogel L, Degli-Esposti MA, Vivier E, Waddell N, Linden J, Huntington ND, et al. A2AR adenosine signaling suppresses natural killer cell maturation in the tumor microenvironment. Cancer Research. PMID 29229601 DOI: 10.1158/0008-5472.Can-17-2826 |
0.346 |
|
| 2016 |
Pei H, Linden J. Adenosine Influences Myeloid Cells to Inhibit Aeroallergen Sensitization. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00330.2015. PMID 27016586 DOI: 10.1152/Ajplung.00330.2015 |
0.409 |
|
| 2016 |
Cekic C, Linden J. Purinergic regulation of the immune system. Nature Reviews. Immunology. 16: 177-92. PMID 26922909 DOI: 10.1038/Nri.2016.4 |
0.349 |
|
| 2015 |
Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA. Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. Purinergic Signalling. PMID 26385692 DOI: 10.1007/S11302-015-9470-7 |
0.336 |
|
| 2015 |
Tian Y, Marshall M, French BA, Linden J, Yang Z. The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A 2A receptors. Basic Research in Cardiology. 110: 16. PMID 25711314 DOI: 10.1007/S00395-015-0473-X |
0.42 |
|
| 2015 |
Beech J, Saleh L, Frentzel J, Figler H, Corrêa IR, Baker B, Ramspacher C, Marshall M, Dasa S, Linden J, Noren CJ, Kelly KA. Multivalent site-specific phage modification enhances the binding affinity of receptor ligands. Bioconjugate Chemistry. 26: 529-36. PMID 25692462 DOI: 10.1021/Acs.Bioconjchem.5B00011 |
0.328 |
|
| 2014 |
Tian Y, Linden J, French BA, Yang Z. Atorvastatin at reperfusion reduces myocardial infarct size in mice by activating eNOS in bone marrow-derived cells. Plos One. 9: e114375. PMID 25470018 DOI: 10.1371/Journal.Pone.0114375 |
0.311 |
|
| 2014 |
Cekic C, Day YJ, Sag D, Linden J. Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment. Cancer Research. 74: 7250-9. PMID 25377469 DOI: 10.1158/0008-5472.Can-13-3583 |
0.378 |
|
| 2014 |
Cekic C, Linden J. Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment. Cancer Research. 74: 7239-49. PMID 25341542 DOI: 10.1158/0008-5472.Can-13-3581 |
0.399 |
|
| 2014 |
Kurtz CC, Drygiannakis I, Naganuma M, Feldman S, Bekiaris V, Linden J, Ware CF, Ernst PB. Extracellular adenosine regulates colitis through effects on lymphoid and nonlymphoid cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G338-46. PMID 24875104 DOI: 10.1152/Ajpgi.00404.2013 |
0.478 |
|
| 2014 |
Field JJ, Nathan DG, Linden J. The role of adenosine signaling in sickle cell therapeutics. Hematology/Oncology Clinics of North America. 28: 287-99. PMID 24589267 DOI: 10.1016/J.Hoc.2013.11.003 |
0.418 |
|
| 2014 |
Kennedy DP, McRobb FM, Leonhardt SA, Purdy M, Figler H, Marshall MA, Chordia M, Figler R, Linden J, Abagyan R, Yeager M. The second extracellular loop of the adenosine A1 receptor mediates activity of allosteric enhancers. Molecular Pharmacology. 85: 301-9. PMID 24217444 DOI: 10.1124/Mol.113.088682 |
0.338 |
|
| 2014 |
Yu JC, Lin GW, Kim J, Linden J. Activated Human iNKT Cells in Pediatric Sickle Cell Disease Patients and in Culture Upregulate Ectonucleotidase CD39 and Adenosine a2A Receptor Blood. 124: 2734-2734. DOI: 10.1182/Blood.V124.21.2734.2734 |
0.404 |
|
| 2014 |
Pei H, Schaub R, Scheuplein F, Mashal R, Linden J. Antibody Mediated Depletion of iNKT Cells Protects Against Hypoxia-Induced Pulmonary Injury in a Murine Model of Sickle Cell Disease Blood. 124: 2697-2697. DOI: 10.1182/Blood.V124.21.2697.2697 |
0.406 |
|
| 2014 |
Ralainirina N, Chodaczek G, Linden J. Intravital Imaging of Pulmonary Neutrophils in Sickle Cell Anemia Blood. 124: 1398-1398. DOI: 10.1182/Blood.V124.21.1398.1398 |
0.362 |
|
| 2013 |
Cekic C, Sag D, Day YJ, Linden J. Extracellular adenosine regulates naive T cell development and peripheral maintenance. The Journal of Experimental Medicine. 210: 2693-706. PMID 24145516 DOI: 10.1084/Jem.20130249 |
0.333 |
|
| 2013 |
Lin G, Field JJ, Yu JC, Ken R, Neuberg D, Nathan DG, Linden J. NF-κB is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors. Plos One. 8: e74664. PMID 24124453 DOI: 10.1371/Journal.Pone.0074664 |
0.409 |
|
| 2013 |
Field JJ, Lin G, Okam MM, Majerus E, Keefer J, Onyekwere O, Ross A, Campigotto F, Neuberg D, Linden J, Nathan DG. Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson. Blood. 121: 3329-34. PMID 23377438 DOI: 10.1182/Blood-2012-11-465963 |
0.37 |
|
| 2013 |
Ralainirina N, Sonderegger FL, Pei H, Chodaczek G, Linden J. The Use Of Two Photon Microscopy To Image Vaso-Occulsion In Pulmonary Microvessels Of Living Mice With Sickle Cell Disease Blood. 122: 976-976. DOI: 10.1182/Blood.V122.21.976.976 |
0.353 |
|
| 2013 |
Yu JC, Lin G, Ken R, Field JJ, Linden J. The Role Of NF-κB In The Activation Of Human iNKT Cells In Sickle Cell Disease Patients and In Vitro Blood. 122: 2291-2291. DOI: 10.1182/Blood.V122.21.2291.2291 |
0.35 |
|
| 2013 |
Lin G, Yu JC, Field JJ, Nathan DG, Linden J. Human Sickle Cell Disease Increases Numbers and Activation Of Peripheral Blood Myeloid Dendritic Cells, Monocytes, and Neutrophils Blood. 122: 1033-1033. DOI: 10.1182/Blood.V122.21.1033.1033 |
0.351 |
|
| 2012 |
Li Y, Figler RA, Kolling G, Bracken TC, Rieger J, Stevenson RW, Linden J, Guerrant RL, Warren CA. Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment. Bmc Infectious Diseases. 12: 342. PMID 23217055 DOI: 10.1186/1471-2334-12-342 |
0.381 |
|
| 2012 |
Li L, Huang L, Ye H, Song SP, Bajwa A, Lee SJ, Moser EK, Jaworska K, Kinsey GR, Day YJ, Linden J, Lobo PI, Rosin DL, Okusa MD. Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury. The Journal of Clinical Investigation. 122: 3931-42. PMID 23093781 DOI: 10.1172/Jci63170 |
0.418 |
|
| 2012 |
Warren CA, Li Y, Calabrese GM, Freire RS, Zaja-Milatovic S, van Opstal E, Figler RA, Linden J, Guerrant RL. Contribution of adenosine A(2B) receptors in Clostridium difficile intoxication and infection. Infection and Immunity. 80: 4463-73. PMID 23045479 DOI: 10.1128/Iai.00782-12 |
0.414 |
|
| 2012 |
Barletta KE, Cagnina RE, Burdick MD, Linden J, Mehrad B. Adenosine A(2B) receptor deficiency promotes host defenses against gram-negative bacterial pneumonia. American Journal of Respiratory and Critical Care Medicine. 186: 1044-50. PMID 22997203 DOI: 10.1164/Rccm.201204-0622Oc |
0.763 |
|
| 2012 |
Chhabra P, Linden J, Lobo P, Okusa MD, Brayman KL. The immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation. Current Diabetes Reviews. 8: 419-33. PMID 22934547 DOI: 10.2174/157339912803529878 |
0.433 |
|
| 2012 |
Linden J, Cekic C. Regulation of lymphocyte function by adenosine. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2097-103. PMID 22772752 DOI: 10.1161/Atvbaha.111.226837 |
0.46 |
|
| 2012 |
Linden J. Statins counter the effects of hyperlipidemia on iNKT cells: Editorial to: "Statin-induced immunomodulation alters peripheral invariant natural killer T-cell prevalence in hyperlipidemic patients" by E. Nakou et al. Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. 26: 277-9. PMID 22543669 DOI: 10.1007/S10557-012-6391-3 |
0.34 |
|
| 2012 |
Linden J. Role of adenosine in response to vascular inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 843-4. PMID 22423034 DOI: 10.1161/Atvbaha.112.247874 |
0.43 |
|
| 2012 |
Warren CA, Calabrese GM, Li Y, Pawlowski SW, Figler RA, Rieger J, Ernst PB, Linden J, Guerrant RL. Effects of adenosine Aâ‚‚A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice. Bmc Infectious Diseases. 12: 13. PMID 22264229 DOI: 10.1186/1471-2334-12-13 |
0.445 |
|
| 2012 |
Cekic C, Sag D, Li Y, Theodorescu D, Strieter RM, Linden J. Adenosine A2B receptor blockade slows growth of bladder and breast tumors. Journal of Immunology (Baltimore, Md. : 1950). 188: 198-205. PMID 22116822 DOI: 10.4049/Jimmunol.1101845 |
0.386 |
|
| 2012 |
Barletta KE, Cagnina RE, Wallace KL, Ramos SI, Mehrad B, Linden J. Leukocyte compartments in the mouse lung: distinguishing between marginated, interstitial, and alveolar cells in response to injury. Journal of Immunological Methods. 375: 100-10. PMID 21996427 DOI: 10.1016/J.Jim.2011.09.013 |
0.746 |
|
| 2011 |
Emaminia A, Lapar DJ, Zhao Y, Steidle JF, Harris DA, Laubach VE, Linden J, Kron IL, Lau CL. Adenosine Aâ‚‚A agonist improves lung function during ex vivo lung perfusion. The Annals of Thoracic Surgery. 92: 1840-6. PMID 22051279 DOI: 10.1016/J.Athoracsur.2011.06.062 |
0.401 |
|
| 2011 |
Wilson JM, Kurtz CC, Black SG, Ross WG, Alam MS, Linden J, Ernst PB. The A2B adenosine receptor promotes Th17 differentiation via stimulation of dendritic cell IL-6. Journal of Immunology (Baltimore, Md. : 1950). 186: 6746-52. PMID 21593380 DOI: 10.4049/Jimmunol.1100117 |
0.412 |
|
| 2011 |
Linden J. Regulation of leukocyte function by adenosine receptors. Advances in Pharmacology (San Diego, Calif.). 61: 95-114. PMID 21586357 DOI: 10.1016/B978-0-12-385526-8.00004-7 |
0.516 |
|
| 2011 |
Jacobson KA, Linden J. Pharmacology of purine and pyrimidine receptors. Preface. Advances in Pharmacology (San Diego, Calif.). 61: xv-xvi. PMID 21586353 DOI: 10.1016/B978-0-12-385526-8.00020-5 |
0.402 |
|
| 2011 |
Field JJ, Nathan DG, Linden J. Targeting iNKT cells for the treatment of sickle cell disease. Clinical Immunology (Orlando, Fla.). 140: 177-83. PMID 21429807 DOI: 10.1016/J.Clim.2011.03.002 |
0.501 |
|
| 2011 |
Fredholm BB, IJzerman AP, Jacobson KA, Linden J, Müller CE. International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update. Pharmacological Reviews. 63: 1-34. PMID 21303899 DOI: 10.1124/Pr.110.003285 |
0.413 |
|
| 2011 |
Figler RA, Wang G, Srinivasan S, Jung DY, Zhang Z, Pankow JS, Ravid K, Fredholm B, Hedrick CC, Rich SS, Kim JK, LaNoue KF, Linden J. Links between Insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans Diabetes. 60: 669-679. PMID 21270276 DOI: 10.2337/Db10-1070 |
0.347 |
|
| 2011 |
Field J, Lin G, Okam M, Majerus E, Onyekwere O, Ross A, Neuberg D, Campigotto F, Nathan DG, Linden J. Regadenoson, An Adenosine 2A Receptor Agonist, Is Safe and Inhibits Invariant NKT Cells in Sickle Cell Disease Blood. 118: 849-849. DOI: 10.1182/Blood.V118.21.849.849 |
0.404 |
|
| 2010 |
Polanowska-Grabowska R, Wallace K, Field JJ, Chen L, Marshall MA, Figler R, Gear AR, Linden J. P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2392-9. PMID 21071696 DOI: 10.1161/Atvbaha.110.211615 |
0.726 |
|
| 2010 |
Zhao Y, LaPar DJ, Steidle J, Emaminia A, Kron IL, Ailawadi G, Linden J, Lau CL. Adenosine signaling via the adenosine 2B receptor is involved in bronchiolitis obliterans development. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 29: 1405-14. PMID 20920842 DOI: 10.1016/J.Healun.2010.07.005 |
0.46 |
|
| 2010 |
Wallace KL, Linden J. Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease. Blood. 116: 5010-20. PMID 20798237 DOI: 10.1182/Blood-2010-06-290643 |
0.785 |
|
| 2010 |
Schwindinger WF, Mihalcik LJ, Giger KE, Betz KS, Stauffer AM, Linden J, Herve D, Robishaw JD. Adenosine A2A receptor signaling and golf assembly show a specific requirement for the gamma7 subtype in the striatum. The Journal of Biological Chemistry. 285: 29787-96. PMID 20639202 DOI: 10.1074/Jbc.M110.142620 |
0.345 |
|
| 2010 |
Gazoni LM, Walters DM, Unger EB, Linden J, Kron IL, Laubach VE. Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. The Journal of Thoracic and Cardiovascular Surgery. 140: 440-6. PMID 20398911 DOI: 10.1016/J.Jtcvs.2010.03.002 |
0.492 |
|
| 2010 |
Devine SM, Gregg A, Figler H, McIntosh K, Urmaliya V, Linden J, Pouton CW, White PJ, Bottle SE, Scammells PJ. Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists. Bioorganic & Medicinal Chemistry. 18: 3078-87. PMID 20385496 DOI: 10.1016/J.Bmc.2010.03.047 |
0.432 |
|
| 2010 |
Chhabra P, Wang K, Zeng Q, Jecmenica M, Langman L, Linden J, Ketchum RJ, Brayman KL. Adenosine A(2A) agonist administration improves islet transplant outcome: Evidence for the role of innate immunity in islet graft rejection. Cell Transplantation. 19: 597-612. PMID 20350347 DOI: 10.3727/096368910X491806 |
0.431 |
|
| 2010 |
Wang H, Zhang W, Tang R, Zhu C, Bucher C, Blazar BR, Geng JG, Zhang C, Linden J, Wu C, Huo Y. Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 915-22. PMID 20167656 DOI: 10.1161/Atvbaha.109.202572 |
0.429 |
|
| 2010 |
Sun WC, Berghaus LJ, Moore JN, Hurley DJ, Vandenplas ML, Thompson R, Linden J. Lipopolysaccharide and TNF-alpha modify adenosine A(2A) receptor expression and function in equine monocytes. Veterinary Immunology and Immunopathology. 135: 289-95. PMID 20056284 DOI: 10.1016/J.Vetimm.2009.12.001 |
0.461 |
|
| 2010 |
Sharma AK, Laubach VE, Ramos SI, Zhao Y, Stukenborg G, Linden J, Kron IL, Yang Z. Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. The Journal of Thoracic and Cardiovascular Surgery. 139: 474-82. PMID 19909990 DOI: 10.1016/J.Jtcvs.2009.08.033 |
0.497 |
|
| 2010 |
Lappas CM, Liu PC, Linden J, Kang EM, Malech HL. Adenosine A2A receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantation. Journal of Leukocyte Biology. 87: 345-54. PMID 19889728 DOI: 10.1189/Jlb.0609388 |
0.772 |
|
| 2010 |
Sun WC, Moore JN, Hurley DJ, Vandenplas ML, Fortes B, Thompson R, Linden J. Differential modulation of lipopolysaccharide-induced expression of inflammatory genes in equine monocytes through activation of adenosine A2A receptors. Veterinary Immunology and Immunopathology. 134: 169-77. PMID 19766323 DOI: 10.1016/J.Vetimm.2009.08.018 |
0.425 |
|
| 2009 |
Lau CL, Zhao Y, Kron IL, Stoler MH, Laubach VE, Ailawadi G, Linden J. The role of adenosine A2A receptor signaling in bronchiolitis obliterans. The Annals of Thoracic Surgery. 88: 1071-8. PMID 19766783 DOI: 10.1016/J.Athoracsur.2009.06.032 |
0.496 |
|
| 2009 |
Aurelio L, Valant C, Figler H, Flynn BL, Linden J, Sexton PM, Christopoulos A, Scammells PJ. 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists. Bioorganic & Medicinal Chemistry. 17: 7353-61. PMID 19751980 DOI: 10.1016/J.Bmc.2009.08.024 |
0.393 |
|
| 2009 |
Cagnina RE, Ramos SI, Marshall MA, Wang G, Frazier CR, Linden J. Adenosine A2B receptors are highly expressed on murine type II alveolar epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 297: L467-74. PMID 19574419 DOI: 10.1152/Ajplung.90553.2008 |
0.803 |
|
| 2009 |
Sharma AK, Linden J, Kron IL, Laubach VE. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respiratory Research. 10: 58. PMID 19558673 DOI: 10.1186/1465-9921-10-58 |
0.379 |
|
| 2009 |
Patel RA, Glover DK, Broisat A, Kabul HK, Ruiz M, Goodman NC, Kramer CM, Meerdink DJ, Linden J, Beller GA. Reduction in myocardial infarct size at 48 hours after brief intravenous infusion of ATL-146e, a highly selective adenosine A2A receptor agonist. American Journal of Physiology. Heart and Circulatory Physiology. 297: H637-42. PMID 19502555 DOI: 10.1152/Ajpheart.00705.2008 |
0.385 |
|
| 2009 |
Wallace KL, Marshall MA, Ramos SI, Lannigan JA, Field JJ, Strieter RM, Linden J. NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines. Blood. 114: 667-76. PMID 19433855 DOI: 10.1182/Blood-2009-02-205492 |
0.757 |
|
| 2009 |
Wang H, Zhang W, Zhu C, Bucher C, Blazar BR, Zhang C, Chen JF, Linden J, Wu C, Huo Y. Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1046-52. PMID 19407243 DOI: 10.1161/Atvbaha.109.188839 |
0.457 |
|
| 2009 |
Lau CL, Zhao Y, Kim J, Kron IL, Sharma A, Yang Z, Laubach VE, Linden J, Ailawadi G, Pinsky DJ. Enhanced fibrinolysis protects against lung ischemia-reperfusion injury. The Journal of Thoracic and Cardiovascular Surgery. 137: 1241-8. PMID 19379998 DOI: 10.1016/J.Jtcvs.2008.12.029 |
0.314 |
|
| 2009 |
Wilson JM, Ross WG, Agbai ON, Frazier R, Figler RA, Rieger J, Linden J, Ernst PB. The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 4616-23. PMID 19342636 DOI: 10.4049/Jimmunol.0801279 |
0.466 |
|
| 2009 |
Koizumi S, Odashima M, Otaka M, Jin M, Linden J, Watanabe S, Ohnishi H. Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. Journal of Gastroenterology. 44: 419-25. PMID 19333545 DOI: 10.1007/S00535-009-0028-8 |
0.433 |
|
| 2009 |
Alam MS, Kurtz CC, Wilson JM, Burnette BR, Wiznerowicz EB, Ross WG, Rieger JM, Figler RA, Linden J, Crowe SE, Ernst PB. A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence. Mucosal Immunology. 2: 232-42. PMID 19262506 DOI: 10.1038/Mi.2009.4 |
0.477 |
|
| 2009 |
Yang Z, Sharma AK, Linden J, Kron IL, Laubach VE. CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury. The Journal of Thoracic and Cardiovascular Surgery. 137: 695-702; discussion . PMID 19258091 DOI: 10.1016/J.Jtcvs.2008.10.044 |
0.355 |
|
| 2009 |
Awad AS, Rouse M, Huang L, Vergis AL, Reutershan J, Cathro HP, Linden J, Okusa MD. Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury. Kidney International. 75: 689-98. PMID 19129795 DOI: 10.1038/Ki.2008.648 |
0.333 |
|
| 2009 |
Sullivan GW, Linden J. Role of neutrophil purinergic receptors in organ dysfunction Journal of Organ Dysfunction. 5: 147-160. DOI: 10.1080/17471060701682310 |
0.493 |
|
| 2009 |
Koizumi S, Odashima M, Linden J, Kinoshita N, Onochi K, Ohba R, Kataoka J, Hatakeyama N, Hama K, Matsuhashi T, Inaba Y, Mashima H, Jin M, Ohnishi H. T1960 Attenuation of Gastric Mucosal Inflammation Induced By Indomethacin Through Activation of the A2A Adenosine Receptor in Rats Gastroenterology. 136. DOI: 10.1016/S0016-5085(09)62807-9 |
0.361 |
|
| 2008 |
Moore CC, Martin EN, Lee GH, Obrig T, Linden J, Scheld WM. An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis models. Bmc Infectious Diseases. 8: 141. PMID 18937852 DOI: 10.1186/1471-2334-8-141 |
0.455 |
|
| 2008 |
Yang Z, Linden J, Berr SS, Kron IL, Beller GA, French BA. Timing of adenosine 2A receptor stimulation relative to reperfusion has differential effects on infarct size and cardiac function as assessed in mice by MRI. American Journal of Physiology. Heart and Circulatory Physiology. 295: H2328-35. PMID 18849340 DOI: 10.1152/Ajpheart.00091.2008 |
0.369 |
|
| 2008 |
Ferguson GN, Valant C, Horne J, Figler H, Flynn BL, Linden J, Chalmers DK, Sexton PM, Christopoulos A, Scammells PJ. 2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists. Journal of Medicinal Chemistry. 51: 6165-72. PMID 18771255 DOI: 10.1021/Jm800557D |
0.457 |
|
| 2008 |
Haskó G, Linden J, Cronstein B, Pacher P. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nature Reviews. Drug Discovery. 7: 759-70. PMID 18758473 DOI: 10.1038/Nrd2638 |
0.461 |
|
| 2008 |
Rork TH, Wallace KL, Kennedy DP, Marshall MA, Lankford AR, Linden J. Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1825-33. PMID 18757481 DOI: 10.1152/Ajpheart.495.2008 |
0.741 |
|
| 2008 |
Kolachala VL, Vijay-Kumar M, Dalmasso G, Yang D, Linden J, Wang L, Gewirtz A, Ravid K, Merlin D, Sitaraman SV. A2B adenosine receptor gene deletion attenuates murine colitis. Gastroenterology. 135: 861-70. PMID 18601927 DOI: 10.1053/J.Gastro.2008.05.049 |
0.422 |
|
| 2008 |
Kolachala VL, Ruble BK, Vijay-Kumar M, Wang L, Mwangi S, Figler HE, Figler RA, Srinivasan S, Gewirtz AT, Linden J, Merlin D, Sitaraman SV. Blockade of adenosine A 2B receptors ameliorates murine colitis British Journal of Pharmacology. 155: 127-137. PMID 18536750 DOI: 10.1038/Bjp.2008.227 |
0.453 |
|
| 2008 |
Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF. A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2970-5. PMID 18354001 DOI: 10.1523/Jneurosci.5255-07.2008 |
0.415 |
|
| 2008 |
Reece TB, Tribble CG, Okonkwo DO, Davis JD, Maxey TS, Gazoni LM, Linden J, Kron IL, Kern JA. Early adenosine receptor activation ameliorates spinal cord reperfusion injury. Journal of Cardiovascular Medicine (Hagerstown, Md.). 9: 363-7. PMID 18334890 DOI: 10.2459/Jcm.0B013E3282Eee836 |
0.353 |
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| 2008 |
Yu L, Shen HY, Coelho JE, Araújo IM, Huang QY, Day YJ, Rebola N, Canas PM, Rapp EK, Ferrara J, Taylor D, Müller CE, Linden J, Cunha RA, Chen JF. Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms. Annals of Neurology. 63: 338-46. PMID 18300283 DOI: 10.1002/Ana.21313 |
0.43 |
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| 2008 |
Gazoni LM, Laubach VE, Mulloy DP, Bellizzi A, Unger EB, Linden J, Ellman PI, Lisle TC, Kron IL. Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusion. The Journal of Thoracic and Cardiovascular Surgery. 135: 156-65. PMID 18179933 DOI: 10.1016/J.Jtcvs.2007.08.041 |
0.432 |
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| 2008 |
Awad AS, Rouse M, Liu L, Vergis AL, Rosin DL, Linden J, Sedor JR, Okusa MD. Activation of adenosine 2A receptors preserves structure and function of podocytes. Journal of the American Society of Nephrology : Jasn. 19: 59-68. PMID 18045850 DOI: 10.1681/Asn.2007030276 |
0.439 |
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| 2008 |
Aurelio L, Figler H, Flynn BL, Linden J, Scammells PJ. 5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers. Bioorganic & Medicinal Chemistry. 16: 1319-27. PMID 17980606 DOI: 10.1016/J.Bmc.2007.10.065 |
0.454 |
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| 2008 |
Ellman PI, Reece TB, Law MG, Gazoni LM, Singh R, Laubach VE, Linden J, Tribble CG, Kron IL. Adenosine A2A activation attenuates nontransplantation lung reperfusion injury. The Journal of Surgical Research. 149: 3-8. PMID 17937935 DOI: 10.1016/J.Jss.2007.08.008 |
0.384 |
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| 2008 |
Sun WC, Moore JN, Hurley DJ, Vandenplas ML, Linden J, Cao Z, Murray TF. Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes. Veterinary Immunology and Immunopathology. 121: 91-100. PMID 17913243 DOI: 10.1016/J.Vetimm.2007.08.011 |
0.474 |
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| 2008 |
Zarek PE, Huang CT, Lutz ER, Kowalski J, Horton MR, Linden J, Drake CG, Powell JD. A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood. 111: 251-9. PMID 17909080 DOI: 10.1182/Blood-2007-03-081646 |
0.438 |
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| 2008 |
Rork TH, Wallace KL, Kennedy DP, Marshall MA, Lankford AR, Linden J. Resident cardiac mast cells contribute to ischemia-reperfusion injury in the isolated, perfused mouse heart The Faseb Journal. 22: 47-47. DOI: 10.1096/Fasebj.22.2_Supplement.47 |
0.718 |
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| 2008 |
Kolachala VL, Vijay-Kumar M, Wang L, Yang D, Marshall M, Wang G, Linden J, Gewirtz AT, Merlin D, Ravid K, Sitaraman SV. S1296 A2b Adenosine Receptor Gene Deletion or Antagonism Attenuates Murine Colitis Gastroenterology. 134: A-220. DOI: 10.1016/S0016-5085(08)61018-5 |
0.382 |
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| 2007 |
Clark AN, Youkey R, Liu X, Jia L, Blatt R, Day YJ, Sullivan GW, Linden J, Tucker AL. A1 adenosine receptor activation promotes angiogenesis and release of VEGF from monocytes. Circulation Research. 101: 1130-8. PMID 17901362 DOI: 10.1161/Circresaha.107.150110 |
0.479 |
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| 2007 |
Sun WC, Moore JN, Hurley DJ, Vandenplas ML, Linden JM, Murray TF. Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils. American Journal of Veterinary Research. 68: 981-7. PMID 17764413 DOI: 10.2460/ajvr.68.9.981 |
0.354 |
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| 2007 |
Gregg A, Bottle SE, Devine SM, Figler H, Linden J, White P, Pouton CW, Urmaliya V, Scammells PJ. Dual acting antioxidant A1 adenosine receptor agonists. Bioorganic & Medicinal Chemistry Letters. 17: 5437-41. PMID 17689079 DOI: 10.1016/J.Bmcl.2007.07.035 |
0.475 |
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| 2007 |
Reutershan J, Cagnina RE, Chang D, Linden J, Ley K. Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury. Journal of Immunology (Baltimore, Md. : 1950). 179: 1254-63. PMID 17617618 DOI: 10.4049/Jimmunol.179.2.1254 |
0.805 |
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| 2007 |
Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. The Journal of Experimental Medicine. 204: 1257-65. PMID 17502665 DOI: 10.1084/Jem.20062512 |
0.32 |
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| 2007 |
Sevigny CP, Li L, Awad AS, Huang L, McDuffie M, Linden J, Lobo PI, Okusa MD. Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition. Journal of Immunology (Baltimore, Md. : 1950). 178: 4240-9. PMID 17371980 DOI: 10.4049/Jimmunol.178.7.4240 |
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| 2007 |
Glover DK, Ruiz M, Takehana K, Petruzella FD, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA. Cardioprotection by adenosine A2A agonists in a canine model of myocardial stunning produced by multiple episodes of transient ischemia. American Journal of Physiology. Heart and Circulatory Physiology. 292: H3164-71. PMID 17308004 DOI: 10.1152/Ajpheart.00743.2005 |
0.45 |
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| 2007 |
Ernst P, Worthington M, Linden J, Naganuma M. Oral treatment of mice with adenosine A2A receptor agonist inhibits Tcell mediated colitis Inflammatory Bowel Diseases. 13: 643. DOI: 10.1097/00054725-200705001-00001 |
0.3 |
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| 2007 |
Tang R, Wang H, Chen J, Linden J. Leukocyte adenosine A2A receptor activation inhibits leukocyte‐endothelial interactions in vivo The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A127 |
0.42 |
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| 2007 |
Gazoni LM, Tribble CG, Ellman PI, Laubach VE, Linden J, Kron IL. 49: A1, A2, or A3 adenosine receptor activation ameliorates lung ischemia reperfusion injury Journal of Heart and Lung Transplantation. 26. DOI: 10.1016/J.Healun.2006.11.063 |
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| 2006 |
Linden J. Cell biology. Purinergic chemotaxis. Science (New York, N.Y.). 314: 1689-90. PMID 17170280 DOI: 10.1126/Science.1137190 |
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| 2006 |
Kiesman WF, Zhao J, Conlon PR, Dowling JE, Petter RC, Lutterodt F, Jin X, Smits G, Fure M, Jayaraj A, Kim J, Sullivan G, Linden J. Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. Journal of Medicinal Chemistry. 49: 7119-31. PMID 17125264 DOI: 10.1021/Jm0605381 |
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| 2006 |
Lappas CM, Day YJ, Marshall MA, Engelhard VH, Linden J. Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. The Journal of Experimental Medicine. 203: 2639-48. PMID 17088433 DOI: 10.1084/Jem.20061097 |
0.775 |
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| 2006 |
Huang QY, Wei C, Yu L, Coelho JE, Shen HY, Kalda A, Linden J, Chen JF. Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11371-8. PMID 17079665 DOI: 10.1523/Jneurosci.1907-06.2006 |
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| 2006 |
Yang Z, Day YJ, Toufektsian MC, Xu Y, Ramos SI, Marshall MA, French BA, Linden J. Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes. Circulation. 114: 2056-64. PMID 17060376 DOI: 10.1161/Circulationaha.106.649244 |
0.392 |
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| 2006 |
McIntire WE, MacCleery G, Murphree LJ, Kerchner KR, Linden J, Garrison JC. Influence of differential stability of G protein βγ dimers containing the γ11 subunit on functional activity at the M1 muscarinic receptor, A1 adenosine receptor, and phospholipase C-β. Biochemistry. 45: 11616-31. PMID 16981721 DOI: 10.1021/Bi0604882 |
0.787 |
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| 2006 |
Pickel VM, Chan J, Linden J, Rosin DL. Subcellular distributions of adenosine A1 and A2A receptors in the rat dorsomedial nucleus of the solitary tract at the level of the area postrema. Synapse (New York, N.Y.). 60: 496-509. PMID 16952160 DOI: 10.1002/Syn.20326 |
0.439 |
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| 2006 |
Naganuma M, Wiznerowicz EB, Lappas CM, Linden J, Worthington MT, Ernst PB. Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. Journal of Immunology (Baltimore, Md. : 1950). 177: 2765-9. PMID 16920910 DOI: 10.4049/Jimmunol.177.5.2765 |
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| 2006 |
Reece TB, Kron IL, Okonkwo DO, Laurent JJ, Tache-Leon C, Maxey TS, Ellman PI, Linden J, Tribble CG, Kern JA. Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism. Journal of Vascular Surgery. 44: 392-7. PMID 16890874 DOI: 10.1016/J.Jvs.2006.04.032 |
0.421 |
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| 2006 |
Odashima M, Otaka M, Jin M, Horikawa Y, Matsuhashi T, Ohba R, Linden J, Watanabe S. A selective adenosine A2A receptor agonist, ATL-146e, prevents concanavalin A-induced acute liver injury in mice. Biochemical and Biophysical Research Communications. 347: 949-54. PMID 16859640 DOI: 10.1016/J.Bbrc.2006.06.185 |
0.44 |
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| 2006 |
Brandon CI, Vandenplas M, Dookwah H, Linden J, Murray TF. Cloning and pharmacological characterization of the equine adenosine A2A receptor: a potential therapeutic target for the treatment of equine endotoxemia Journal of Veterinary Pharmacology and Therapeutics. 29: 243-253. PMID 16846461 DOI: 10.1111/J.1365-2885.2006.00746.X |
0.478 |
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| 2006 |
Linden J. New insights into the regulation of inflammation by adenosine. The Journal of Clinical Investigation. 116: 1835-7. PMID 16823484 DOI: 10.1172/Jci29125 |
0.441 |
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| 2006 |
Li Y, Oskouian RJ, Day YJ, Rieger JM, Liu L, Kern JA, Linden J. Mouse spinal cord compression injury is reduced by either activation of the adenosine A2A receptor on bone marrow-derived cells or deletion of the A2A receptor on non-bone marrow-derived cells. Neuroscience. 141: 2029-39. PMID 16777350 DOI: 10.1016/J.Neuroscience.2006.05.014 |
0.427 |
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| 2006 |
Yan X, Koos BJ, Kruger L, Linden J, Murray TF. Characterization of [125I]ZM 241385 binding to adenosine A2A receptors in the pineal of sheep brain. Brain Research. 1096: 30-9. PMID 16764836 DOI: 10.1016/J.Brainres.2006.04.072 |
0.467 |
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| 2006 |
Linden J. Adenosine metabolism and cancer. Focus on "Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatases and reducing ERK1/2 activity via a novel pathway". American Journal of Physiology. Cell Physiology. 291: C405-6. PMID 16707553 DOI: 10.1152/Ajpcell.00242.2006 |
0.322 |
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| 2006 |
Cavalcante IC, Castro MV, Barreto AR, Sullivan GW, Vale M, Almeida PR, Linden J, Rieger JM, Cunha FQ, Guerrant RL, Ribeiro RA, Brito GA. Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis. Infection and Immunity. 74: 2606-12. PMID 16622196 DOI: 10.1128/Iai.74.5.2606-2612.2006 |
0.466 |
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| 2006 |
Day YJ, Huang L, Ye H, Li L, Linden J, Okusa MD. Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gamma. Journal of Immunology (Baltimore, Md. : 1950). 176: 3108-14. PMID 16493070 DOI: 10.4049/Jimmunol.176.5.3108 |
0.436 |
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| 2006 |
Odashima M, Otaka M, Jin M, Komatsu K, Wada I, Horikawa Y, Matsuhashi T, Hatakeyama N, Oyake J, Ohba R, Watanabe S, Linden J. Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats. World Journal of Gastroenterology. 12: 568-73. PMID 16489670 DOI: 10.3748/Wjg.V12.I4.568 |
0.41 |
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| 2006 |
Reece TB, Okonkwo DO, Ellman PI, Maxey TS, Tache-Leon C, Warren PS, Laurent JJ, Linden J, Kron IL, Tribble CG, Kern JA. Comparison of systemic and retrograde delivery of adenosine A2A agonist for attenuation of spinal cord injury after thoracic aortic cross-clamping. The Annals of Thoracic Surgery. 81: 902-9. PMID 16488692 DOI: 10.1016/J.Athoracsur.2005.09.023 |
0.317 |
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| 2006 |
Zhu R, Frazier CR, Linden J, Macdonald TL. N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists. Bioorganic & Medicinal Chemistry Letters. 16: 2416-8. PMID 16487705 DOI: 10.1016/J.Bmcl.2006.01.110 |
0.344 |
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| 2006 |
Kiesman WF, Zhao J, Conlon PR, Petter RC, Jin X, Smits G, Lutterodt F, Sullivan GW, Linden J. Norbornyllactone-substituted xanthines as adenosine A(1) receptor antagonists. Bioorganic & Medicinal Chemistry. 14: 3654-61. PMID 16458010 DOI: 10.1016/J.Bmc.2006.01.021 |
0.443 |
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| 2006 |
Bhattacharya S, Youkey RL, Ghartey K, Leonard M, Linden J, Tucker AL. The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs. The Biochemical Journal. 396: 139-46. PMID 16390330 DOI: 10.1042/Bj20051422 |
0.406 |
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| 2006 |
Awad AS, Huang L, Ye H, Duong ET, Bolton WK, Linden J, Okusa MD. Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy. American Journal of Physiology. Renal Physiology. 290: F828-37. PMID 16332931 DOI: 10.1152/Ajprenal.00310.2005 |
0.383 |
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| 2006 |
Nikolakopoulos G, Figler H, Linden J, Scammells PJ. 2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers. Bioorganic & Medicinal Chemistry. 14: 2358-2365. PMID 16314104 DOI: 10.1016/J.Bmc.2005.11.018 |
0.374 |
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| 2006 |
Linden J. Ups and downs of adenosine Blood. 108: 1430-1430. DOI: 10.1182/Blood-2006-06-028480 |
0.371 |
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| 2005 |
Toufektsian MC, Yang Z, Prasad KM, Overbergh L, Ramos SI, Mathieu C, Linden J, French BA. Stimulation of A2A-adenosine receptors after myocardial infarction suppresses inflammatory activation and attenuates contractile dysfunction in the remote left ventricle. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1410-8. PMID 16284233 DOI: 10.1152/Ajpheart.00860.2005 |
0.413 |
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| 2005 |
Chordia MD, Zigler M, Murphree LJ, Figler H, Macdonald TL, Olsson RA, Linden J. 6-Aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency Journal of Medicinal Chemistry. 48: 5131-5139. PMID 16078833 DOI: 10.1021/Jm049132J |
0.818 |
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| 2005 |
Murphree LJ, Sullivan GW, Marshall MA, Linden J. Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction. The Biochemical Journal. 391: 575-80. PMID 16022683 DOI: 10.1042/Bj20050888 |
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| 2005 |
Lappas CM, Sullivan GW, Linden J. Adenosine A2A agonists in development for the treatment of inflammation. Expert Opinion On Investigational Drugs. 14: 797-806. PMID 16022569 DOI: 10.1517/13543784.14.7.797 |
0.784 |
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| 2005 |
Odashima M, Bamias G, Rivera-Nieves J, Linden J, Nast CC, Moskaluk CA, Marini M, Sugawara K, Kozaiwa K, Otaka M, Watanabe S, Cominelli F. Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease. Gastroenterology. 129: 26-33. PMID 16012931 DOI: 10.1053/J.Gastro.2005.05.032 |
0.46 |
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| 2005 |
Odashima M, Otaka M, Jin M, Komatsu K, Wada I, Matsuhashi T, Horikawa Y, Hatakeyama N, Oyake J, Ohba R, Linden J, Watanabe S. Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice. Journal of Gastroenterology. 40: 526-9. PMID 15942719 DOI: 10.1007/S00535-005-1609-9 |
0.34 |
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| 2005 |
Reece TB, Ellman PI, Maxey TS, Crosby IK, Warren PS, Chong TW, LeGallo RD, Linden J, Kern JA, Tribble CG, Kron IL. Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation. The Journal of Thoracic and Cardiovascular Surgery. 129: 1137-43. PMID 15867791 DOI: 10.1016/J.Jtcvs.2004.11.042 |
0.341 |
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| 2005 |
Yang Z, Day YJ, Toufektsian MC, Ramos SI, Marshall M, Wang XQ, French BA, Linden J. Infarct-sparing effect of A2A-adenosine receptor activation is due primarily to its action on lymphocytes. Circulation. 111: 2190-7. PMID 15851591 DOI: 10.1161/01.Cir.0000163586.62253.A5 |
0.402 |
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| 2005 |
Lange-Sperandio B, Forbes MS, Thornhill B, Okusa MD, Linden J, Chevalier RL. A2A adenosine receptor agonist and PDE4 inhibition delays inflammation but fails to reduce injury in experimental obstructive nephropathy. Nephron. Experimental Nephrology. 100: e113-23. PMID 15824514 DOI: 10.1159/000085057 |
0.417 |
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| 2005 |
Day YJ, Li Y, Rieger JM, Ramos SI, Okusa MD, Linden J. A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injury. Journal of Immunology (Baltimore, Md. : 1950). 174: 5040-6. PMID 15814735 DOI: 10.4049/Jimmunol.174.8.5040 |
0.438 |
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| 2005 |
Reece TB, Laubach VE, Tribble CG, Maxey TS, Ellman PI, Warren PS, Schulman AM, Linden J, Kern JA, Kron IL. Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury. The Annals of Thoracic Surgery. 79: 1189-95. PMID 15797048 DOI: 10.1016/J.Athoracsur.2004.09.038 |
0.361 |
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| 2005 |
Linden J. Adenosine in tissue protection and tissue regeneration. Molecular Pharmacology. 67: 1385-7. PMID 15703375 DOI: 10.1124/Mol.105.011783 |
0.403 |
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| 2005 |
Odashima M, Otaka M, Jin M, Komatsu K, Wada I, Matsuhashi T, Horikawa Y, Hatakeyama N, Oyake J, Ohba R, Linden J, Watanabe S. Selective adenosine A receptor agonist, ATL-146e, attenuates stress-induced gastric lesions in rats. Journal of Gastroenterology and Hepatology. 20: 275-80. PMID 15683432 DOI: 10.1111/J.1440-1746.2004.03555.X |
0.391 |
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| 2005 |
Lappas CM, Rieger JM, Linden J. A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 174: 1073-80. PMID 15634932 DOI: 10.4049/Jimmunol.174.2.1073 |
0.791 |
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| 2005 |
Bastia E, Xu YH, Scibelli AC, Day YJ, Linden J, Chen JF, Schwarzschild MA. A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 891-900. PMID 15602504 DOI: 10.1038/Sj.Npp.1300630 |
0.422 |
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| 2005 |
Glover DK, Riou LM, Ruiz M, Sullivan GW, Linden J, Rieger JM, Macdonald TL, Watson DD, Beller GA. Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 288: H1851-8. PMID 15591104 DOI: 10.1152/Ajpheart.00362.2004 |
0.428 |
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| 2004 |
Reece TB, Okonkwo DO, Ellman PI, Warren PS, Smith RL, Hawkins AS, Linden J, Kron IL, Tribble CG, Kern JA. The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation. The Journal of Thoracic and Cardiovascular Surgery. 128: 925-32. PMID 15573078 DOI: 10.1016/J.Jtcvs.2004.08.019 |
0.429 |
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| 2004 |
Day YJ, Huang L, Ye H, Linden J, Okusa MD. Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages. American Journal of Physiology. Renal Physiology. 288: F722-31. PMID 15561971 DOI: 10.1152/Ajprenal.00378.2004 |
0.477 |
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| 2004 |
Hutchinson SA, Baker SP, Linden J, Scammells PJ. New potent and selective A1 adenosine receptor agonists. Bioorganic & Medicinal Chemistry. 12: 4877-84. PMID 15336267 DOI: 10.1016/j.bmc.2004.07.004 |
0.364 |
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| 2004 |
Reece TB, Davis JD, Okonkwo DO, Maxey TS, Ellman PI, Li X, Linden J, Tribble CG, Kron IL, Kern JA. Adenosine A2A analogue reduces long-term neurologic injury after blunt spinal trauma. The Journal of Surgical Research. 121: 130-4. PMID 15313386 DOI: 10.1016/J.Jss.2004.04.006 |
0.333 |
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| 2004 |
Sullivan GW, Fang G, Linden J, Scheld WM. A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis. The Journal of Infectious Diseases. 189: 1897-904. PMID 15122527 DOI: 10.1086/386311 |
0.35 |
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| 2004 |
Wu Y, Zheng J, Linden J, Holoshitz J. Genoprotective pathways. Part I. Extracellular signaling through G(s) protein-coupled adenosine receptors prevents oxidative DNA damage. Mutation Research. 546: 93-102. PMID 14757197 DOI: 10.1016/J.Mrfmmm.2003.11.003 |
0.351 |
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| 2004 |
Day YJ, Marshall MA, Huang L, McDuffie MJ, Okusa MD, Linden J. Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: Inhibition of chemokine induction American Journal of Physiology - Gastrointestinal and Liver Physiology. 286: G285-G293. PMID 14715520 DOI: 10.1152/Ajpgi.00348.2003 |
0.376 |
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| 2004 |
Sullivan GW, Lee DD, Ross WG, DiVietro JA, Lappas CM, Lawrence MB, Linden J. Activation of A2A adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophils. Journal of Leukocyte Biology. 75: 127-34. PMID 14525968 DOI: 10.1189/Jlb.0603300 |
0.78 |
|
| 2003 |
Bucheimer RE, Linden J. Purinergic regulation of epithelial transport. The Journal of Physiology. 555: 311-21. PMID 14694149 DOI: 10.1113/Jphysiol.2003.056697 |
0.437 |
|
| 2003 |
Rosin DL, Hettinger BD, Lee A, Linden J. Anatomy of adenosine A2A receptors in brain: Morphological substrates for integration of striatal function Neurology. 61: S12-S18. PMID 14663003 DOI: 10.1212/01.Wnl.0000095205.33940.99 |
0.404 |
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| 2003 |
Figler H, Olsson RA, Linden J. Allosteric enhancers of A1 adenosine receptors increase receptor-G protein coupling and counteract Guanine nucleotide effects on agonist binding. Molecular Pharmacology. 64: 1557-64. PMID 14645687 DOI: 10.1124/Mol.64.6.1557 |
0.426 |
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| 2003 |
Benkwitz C, Garrison JC, Linden J, Durieux ME, Hollmann MW. Lidocaine enhances Galphai protein function. Anesthesiology. 99: 1093-101. PMID 14576545 DOI: 10.1097/00000542-200311000-00015 |
0.366 |
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| 2003 |
Day YJ, Huang L, McDuffie MJ, Rosin DL, Ye H, Chen JF, Schwarzschild MA, Fink JS, Linden J, Okusa MD. Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells. The Journal of Clinical Investigation. 112: 883-91. PMID 12975473 DOI: 10.1172/Jci15483 |
0.378 |
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| 2003 |
Le DE, Pelberg RA, Leong-Poi H, Bin JP, Linden J, Kaul S. A1-receptor blockade: a novel approach for assessing myocardial viability in chronic ischemic cardiomyopathy. Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. 16: 764-9. PMID 12835664 DOI: 10.1016/S0894-7317(03)00214-1 |
0.382 |
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| 2003 |
Lütjens H, Zickgraf A, Figler H, Linden J, Olsson RA, Scammells PJ. 2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications. Journal of Medicinal Chemistry. 46: 1870-7. PMID 12723950 DOI: 10.1021/Jm020295M |
0.459 |
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| 2003 |
Platts SH, Linden J, Duling BR. Rapid modification of the glycocalyx caused by ischemia-reperfusion is inhibited by adenosine A2A receptor activation. American Journal of Physiology. Heart and Circulatory Physiology. 284: H2360-7. PMID 12560210 DOI: 10.1152/Ajpheart.00899.2002 |
0.461 |
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| 2003 |
Webb TR, Lvovskiy D, Kim SA, Ji Xd, Melman N, Linden J, Jacobson KA. Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors. Bioorganic & Medicinal Chemistry. 11: 77-85. PMID 12467710 DOI: 10.1016/S0968-0896(02)00323-1 |
0.416 |
|
| 2002 |
Riou LM, Ruiz M, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA, Glover DK. Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A2A-receptor-mediated coronary vasodilation Journal of the American College of Cardiology. 40: 1687-1694. PMID 12427424 DOI: 10.1016/S0735-1097(02)02372-0 |
0.43 |
|
| 2002 |
Fiser SM, Tribble CG, Kaza AK, Long SM, Kern JA, Cassada DC, Linden J, Rieger J, Laubach VE, Matisoff A, Kron IL. Adenosine A2A receptor activation decreases reperfusion injury associated with high-flow reperfusion. The Journal of Thoracic and Cardiovascular Surgery. 124: 973-8. PMID 12407381 DOI: 10.1067/Mtc.2002.124886 |
0.43 |
|
| 2002 |
Linden J. Autoregulation of cyclic AMP in vascular smooth muscle: a role for adenosine receptors. Molecular Pharmacology. 62: 969-70. PMID 12391257 DOI: 10.1124/Mol.62.5.969 |
0.391 |
|
| 2002 |
Cassada DC, Tribble CG, Long SM, Kaza AK, Linden J, Rieger JM, Rosin D, Kron IL, Kern JA. Adenosine A2A agonist reduces paralysis after spinal cord ischemia: correlation with A2A receptor expression on motor neurons. The Annals of Thoracic Surgery. 74: 846-9; discussion 84. PMID 12238849 DOI: 10.1016/S0003-4975(02)03793-1 |
0.346 |
|
| 2002 |
Riou LM, Ruiz M, Sullivan GW, Linden J, Leong-Poi H, Lindner JR, Harris TD, Beller GA, Glover DK. Assessment of myocardial inflammation produced by experimental coronary occlusion and reperfusion with 99mTc-RP517, a new leukotriene B4 receptor antagonist that preferentially labels neutrophils in vivo. Circulation. 106: 592-8. PMID 12147542 DOI: 10.1161/01.Cir.0000023878.04716.6D |
0.382 |
|
| 2002 |
Chordia MD, Murphree LJ, Macdonald TL, Linden J, Olsson RA. 2-Aminothiazoles: A new class of agonist allosteric enhancers of A1 adenosine receptors Bioorganic and Medicinal Chemistry Letters. 12: 1563-1566. PMID 12039562 DOI: 10.1016/S0960-894X(02)00236-6 |
0.81 |
|
| 2002 |
Kim SA, Marshall MA, Melman N, Kim HS, Müller CE, Linden J, Jacobson KA. Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. Journal of Medicinal Chemistry. 45: 2131-8. PMID 12014951 DOI: 10.1021/Jm0104318 |
0.416 |
|
| 2002 |
Murphree LJ, Marshall MA, Rieger JM, MacDonald TL, Linden J. Human A2A adenosine receptors: High-affinity agonist binding to receptor-g protein complexes containing Gβ4 Molecular Pharmacology. 61: 455-462. PMID 11809871 DOI: 10.1124/Mol.61.2.455 |
0.817 |
|
| 2002 |
Tranberg CE, Zickgraf A, Giunta BN, Luetjens H, Figler H, Murphree LJ, Falke R, Fleischer H, Linden J, Scammells PJ, Olsson RA. 2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A(1) adenosine receptors. Journal of Medicinal Chemistry. 45: 382-9. PMID 11784142 DOI: 10.1021/jm010081p |
0.803 |
|
| 2002 |
Peart J, Flood A, Linden J, Matherne GP, Headrick JP. Adenosine-mediated cardioprotection in ischemic-reperfused mouse heart. Journal of Cardiovascular Pharmacology. 39: 117-29. PMID 11743234 DOI: 10.1097/00005344-200201000-00013 |
0.436 |
|
| 2002 |
Riou LM, Ruiz M, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA, Glover DK. Verapamil attenuates the coronary vasodilatory response to adenosine and A 2A adenosine receptor agonists Journal of the American College of Cardiology. 39: 369. DOI: 10.1016/S0735-1097(02)81660-6 |
0.455 |
|
| 2001 |
Cassada DC, Gangemi JJ, Rieger JM, Linden J, Kaza AK, Long SM, Kron IL, Tribble CG, Kern JA. Systemic adenosine A2A agonist ameliorates ischemic reperfusion injury in the rabbit spinal cord. The Annals of Thoracic Surgery. 72: 1245-50. PMID 11603444 DOI: 10.1016/S0003-4975(01)03057-0 |
0.323 |
|
| 2001 |
Cerniway RJ, Yang Z, Jacobson MA, Linden J, Matherne GP. Targeted deletion of A(3) adenosine receptors improves tolerance to ischemia-reperfusion injury in mouse myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 281: H1751-8. PMID 11557567 DOI: 10.1152/Ajpheart.2001.281.4.H1751 |
0.469 |
|
| 2001 |
Glover DK, Ruiz M, Takehana K, Petruzella FD, Riou LM, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA. Pharmacological stress myocardial perfusion imaging with the potent and selective A2A adenosine receptor agonists ATL193 and ATL146e administered by either intravenous infusion or bolus injection Circulation. 104: 1181-1187. PMID 11535577 DOI: 10.1161/Hc3601.093983 |
0.428 |
|
| 2001 |
Cassada DC, Tribble CG, Laubach VE, Nguyen BN, Rieger JM, Linden J, Kaza AK, Long SM, Kron IL, Kern JA. An adenosine A2A agonist, ATL-146e, reduces paralysis and apoptosis during rabbit spinal cord reperfusion. Journal of Vascular Surgery. 34: 482-8. PMID 11533601 DOI: 10.1067/Mva.2001.117996 |
0.321 |
|
| 2001 |
Cassada DC, Tribble CG, Kaza AK, Fiser SM, Long SM, Linden J, Rieger JM, Kron IL, Kern JA. Adenosine analogue reduces spinal cord reperfusion injury in a time-dependent fashion. Surgery. 130: 230-5. PMID 11490354 DOI: 10.1067/Msy.2001.115838 |
0.34 |
|
| 2001 |
Peirce SM, Skalak TC, Rieger JM, Macdonald TL, Linden J. Selective A2A adenosine receptor activation reduces skin pressure ulcer formation and inflammation American Journal of Physiology - Heart and Circulatory Physiology. 281: H67-H74. PMID 11406470 DOI: 10.1152/Ajpheart.2001.281.1.H67 |
0.37 |
|
| 2001 |
Okusa MD, Linden J, Huang L, Rosin DL, Smith DF, Sullivan G. Enhanced protection from renal ischemia-reperfusion [correction of ischemia:reperfusion] injury with A(2A)-adenosine receptor activation and PDE 4 inhibition. Kidney International. 59: 2114-25. PMID 11380813 DOI: 10.1046/J.1523-1755.2001.00726.X |
0.458 |
|
| 2001 |
McPherson JA, Barringhaus KG, Bishop GG, Sanders JM, Rieger JM, Hesselbacher SE, Gimple LW, Powers ER, Macdonald T, Sullivan G, Linden J, Sarembock IJ. Adenosine A(2A) receptor stimulation reduces inflammation and neointimal growth in a murine carotid ligation model. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 791-6. PMID 11348876 DOI: 10.1161/01.Atv.21.5.791 |
0.49 |
|
| 2001 |
Ji X, Kim YC, Ahern DG, Linden J, Jacobson KA. [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochemical Pharmacology. 61: 657-63. PMID 11266650 DOI: 10.1016/S0006-2952(01)00531-7 |
0.416 |
|
| 2001 |
Linden J. Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Annual Review of Pharmacology and Toxicology. 41: 775-87. PMID 11264476 DOI: 10.1146/Annurev.Pharmtox.41.1.775 |
0.514 |
|
| 2001 |
Hogan CJ, Fang GD, Scheld WM, Linden J, Diduch DR. Inhibiting the inflammatory response in joint sepsis. Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 17: 311-315. PMID 11239354 DOI: 10.1053/Jars.2001.21492 |
0.317 |
|
| 2001 |
Sullivan GW, Rieger JM, Scheld WM, Macdonald TL, Linden J. Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists. British Journal of Pharmacology. 132: 1017-26. PMID 11226132 DOI: 10.1038/Sj.Bjp.0703893 |
0.462 |
|
| 2001 |
Armstrong JM, Chen JF, Schwarzschild MA, Apasov S, Smith PT, Caldwell C, Chen P, Figler H, Sullivan G, Fink S, Linden J, Sitkovsky M. Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice. The Biochemical Journal. 354: 123-30. PMID 11171087 DOI: 10.1042/0264-6021:3540123 |
0.336 |
|
| 2001 |
Rieger JM, Brown ML, Sullivan GW, Linden J, Macdonald TL. Design, synthesis, and evaluation of novel A2A adenosine receptor agonists Journal of Medicinal Chemistry. 44: 531-539. PMID 11170643 DOI: 10.1021/Jm0003642 |
0.388 |
|
| 2001 |
Gao Z, Li BS, Day YJ, Linden J. A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis. Molecular Pharmacology. 59: 76-82. PMID 11125027 DOI: 10.1124/Mol.59.1.76 |
0.478 |
|
| 2001 |
Odashima M, Linden J, Kozaiwa K, Rivera-Nieves J, Sugawara K, Moskaluk CA, Nast CC, Matsumoto S, Cominelli F. Anti-inflammatory effects of selective A2A adenosine receptor agonism in experimental inflammatory bowel disease (IBD) Gastroenterology. 120: A280. DOI: 10.1016/S0016-5085(08)81387-X |
0.331 |
|
| 2001 |
Broad RM, Linden J. P1 Receptors in the Cardiovascular System Handbook of Experimental Pharmacology. 151: 3-32. DOI: 10.1007/978-3-642-56921-0_1 |
0.468 |
|
| 2000 |
Okusa MD, Linden J, Huang L, Rieger JM, MacDonald TL, Huynh LP. A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion American Journal of Physiology - Renal Physiology. 279: F809-F818. PMID 11053040 DOI: 10.1152/Ajprenal.2000.279.5.F809 |
0.444 |
|
| 2000 |
Gauda EB, Northington FJ, Linden J, Rosin DL. Differential expression of a(2a), A(1)-adenosine and D(2)-dopamine receptor genes in rat peripheral arterial chemoreceptors during postnatal development. Brain Research. 872: 1-10. PMID 10924669 DOI: 10.1016/S0006-8993(00)02314-3 |
0.44 |
|
| 2000 |
Sullivan GW, Sarembock IJ, Linden J. The role of inflammation in vascular diseases. Journal of Leukocyte Biology. 67: 591-602. PMID 10810997 DOI: 10.1002/Jlb.67.5.591 |
0.301 |
|
| 2000 |
Kim YC, Ji X, Melman N, Linden J, Jacobson KA. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. Journal of Medicinal Chemistry. 43: 1165-72. PMID 10737749 DOI: 10.1021/Jm990421V |
0.465 |
|
| 2000 |
TUCKER AL, JIA L, HOLETON D, TAYLOR AJ, LINDEN J. Dominance of Gs in doubly Gs/Gi-coupled chimaeric A1/A2A adenosine receptors in HEK-293 cells Biochemical Journal. 352: 203-210. DOI: 10.1042/Bj3520203 |
0.478 |
|
| 2000 |
Fenster MS, Shepherd RK, Linden J, Duling BR. Activation of Adenosine A2α Receptors Inhibits Mast Cell Degranulation and Mast Cell–Dependent Vasoconstriction Microcirculation. 7: 129-135. DOI: 10.1038/Sj.Mn.7300101 |
0.509 |
|
| 1999 |
Ross SD, Tribble CG, Linden J, Gangemi JJ, Lanpher BC, Wang AY, Kron IL. Selective adenosine-A2A activation reduces lung reperfusion injury following transplantation. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 18: 994-1002. PMID 10561110 DOI: 10.1016/S1053-2498(99)00066-2 |
0.341 |
|
| 1999 |
Sullivan GW, Linden J, Buster BL, Scheld WM. Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram. The Journal of Infectious Diseases. 180: 1550-60. PMID 10515815 DOI: 10.1086/315084 |
0.435 |
|
| 1999 |
Okusa MD, Linden J, Macdonald T, Huang L. Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney. The American Journal of Physiology. 277: F404-12. PMID 10484524 DOI: 10.1152/Ajprenal.1999.277.3.F404 |
0.396 |
|
| 1999 |
Gao Z, Chen T, Weber MJ, Linden J. A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. cross-talk between cyclic AMP and protein kinase c pathways. The Journal of Biological Chemistry. 274: 5972-80. PMID 10026223 DOI: 10.1074/Jbc.274.9.5972 |
0.325 |
|
| 1999 |
GAO Z, NI Y, SZABO G, LINDEN J. Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors Biochemical Journal. 342: 387-395. DOI: 10.1042/Bj3420387 |
0.463 |
|
| 1999 |
GAO Z, ROBEVA AS, LINDEN J. Purification of A1 adenosine receptor–G-protein complexes: effects of receptor down-regulation and phosphorylation on coupling Biochemical Journal. 338: 729-736. DOI: 10.1042/Bj3380729 |
0.393 |
|
| 1999 |
Kim Y, Karton Y, Ji X, Melman N, Linden J, Jacobson KA. Acyl-hydrazide derivatives of a xanthine carboxylic congener (XCC) as selective antagonists at human A2B adenosine receptors Drug Development Research. 47: 178-188. DOI: 10.1002/(Sici)1098-2299(199908)47:4<178::Aid-Ddr4>3.0.Co;2-L |
0.471 |
|
| 1999 |
Jacobson KA, Ijzerman AP, Linden J. 1,3-dialkylxanthine derivatives having high potency as antagonists at human A2B adenosine receptors Drug Development Research. 47: 45-53. DOI: 10.1002/(Sici)1098-2299(199905)47:1<45::Aid-Ddr6>3.0.Co;2-U |
0.417 |
|
| 1998 |
Rosin DL, Robeva A, Woodard RL, Guyenet PG, Linden J. Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system. The Journal of Comparative Neurology. 401: 163-86. PMID 9822147 DOI: 10.1002/(Sici)1096-9861(19981116)401:2<163::Aid-Cne2>3.0.Co;2-D |
0.383 |
|
| 1998 |
Gilchrist A, Mazzoni MR, Dineen B, Dice A, Linden J, Proctor WR, Lupica CR, Dunwiddie TV, Hamm HE. Antagonists of the receptor-G protein interface block Gi-coupled signal transduction. The Journal of Biological Chemistry. 273: 14912-9. PMID 9614095 DOI: 10.1074/Jbc.273.24.14912 |
0.416 |
|
| 1998 |
Linden J, Auchampach JA, Jin X, Figler RA. The structure and function of A1 and A2B adenosine receptors. Life Sciences. 62: 1519-24. PMID 9585129 DOI: 10.1016/S0024-3205(98)00100-3 |
0.459 |
|
| 1998 |
Sullivan GW, Linden J. Role of A2A adenosine receptors in inflammation Drug Development Research. 45: 103-112. DOI: 10.1002/(Sici)1098-2299(199811/12)45:3/4<103::Aid-Ddr4>3.0.Co;2-W |
0.52 |
|
| 1997 |
Figler RA, Lindorfer MA, Graber SG, Garrison JC, Linden J. Reconstitution of bovine A1 adenosine receptors and G proteins in phospholipid vesicles: betagamma-subunit composition influences guanine nucleotide exchange and agonist binding. Biochemistry. 36: 16288-99. PMID 9405064 DOI: 10.1021/Bi972000Q |
0.422 |
|
| 1997 |
Jin X, Shepherd RK, Duling BR, Linden J. Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. The Journal of Clinical Investigation. 100: 2849-57. PMID 9389751 DOI: 10.1172/Jci119833 |
0.49 |
|
| 1997 |
Pfister JR, Belardinelli L, Lee G, Lum RT, Milner P, Stanley WC, Linden J, Baker SP, Schreiner G. Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine. Journal of Medicinal Chemistry. 40: 1773-8. PMID 9191953 DOI: 10.1021/Jm970013W |
0.443 |
|
| 1997 |
Matherne GP, Linden J, Byford AM, Gauthier NS, Headricr JP. Transgenic A1 adenosine receptor overexpression increases myocardial resistance to ischemia Proceedings of the National Academy of Sciences of the United States of America. 94: 6541-6546. PMID 9177254 DOI: 10.1073/Pnas.94.12.6541 |
0.391 |
|
| 1997 |
Martin PL, Barrett RJ, Linden J, Abraham WM. Pharmacology of 2-cyclohexylmethylidenehydrazinoadenosine (WRC-0470), a novel, short-acting adenosine A2A receptor agonist that produces selective coronary vasodilation Drug Development Research. 40: 313-324. DOI: 10.1002/(Sici)1098-2299(199704)40:4<313::Aid-Ddr5>3.0.Co;2-M |
0.429 |
|
| 1996 |
Mizumura T, Auchampach JA, Linden J, Bruns RF, Gross GJ. PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Circulation Research. 79: 415-423. PMID 8781475 DOI: 10.1161/01.Res.79.3.415 |
0.376 |
|
| 1996 |
Shepherd RK, Linden J, Duling BR. Adenosine-induced vasoconstriction in vivo. Role of the mast cell and A3 adenosine receptor. Circulation Research. 78: 627-34. PMID 8635220 DOI: 10.1161/01.Res.78.4.627 |
0.503 |
|
| 1996 |
Robeva AS, Woodard R, Luthin DR, Taylor HE, Linden J. Double tagging recombinant A1- and A2A-adenosine receptors with hexahistidine and the FLAG epitope. Development of an efficient generic protein purification procedure. Biochemical Pharmacology. 51: 545-55. PMID 8619901 DOI: 10.1016/0006-2952(95)02235-X |
0.387 |
|
| 1996 |
Musser B, Morgan ME, Leid M, Murray TF, Linden J, Vestal RE. Corrigendum to ‘Species comparison of adenosine and β-adrenoceptors in mammalian atrial and ventricular myocardium’. [Eur. J. Pharmacol. Mol. Pharmacol. Sect. 246 (1993) 105–111] European Journal of Pharmacology. 308: 357. DOI: 10.1016/0014-2999(96)00414-1 |
0.429 |
|
| 1996 |
Robeva AS, Woodard RL, Jin X, Gao Z, Bhattacharya S, Taylor HE, Rosin DL, Linden J. Molecular characterization of recombinant human adenosine receptors Drug Development Research. 39: 243-252. DOI: 10.1002/(Sici)1098-2299(199611/12)39:3/4<243::Aid-Ddr3>3.0.Co;2-R |
0.415 |
|
| 1995 |
Cothran DL, Lloyd TR, Taylor H, Linden J, Matherne GP. Ontogeny of rat myocardial A1 adenosine receptors. Biology of the Neonate. 68: 111-8. PMID 8534770 DOI: 10.1159/000244226 |
0.475 |
|
| 1995 |
Bhattacharya S, Linden J. The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins. Biochimica Et Biophysica Acta. 1265: 15-21. PMID 7857979 DOI: 10.1016/0167-4889(94)00204-R |
0.381 |
|
| 1995 |
Luthin DR, Lee KS, Okonkwo D, Zhang P, Linden J. Photoaffinity labeling with 2(-)[2-(4-azido-3(-)[125I]- iodophenyl)ethylamino]adenosine and autoradiography with 2(-)[2-(4-amino-3(-)[125I]iodophenyl)ethylamino]adenosine of A2a adenosine receptors in rat brain. Journal of Neurochemistry. 65: 2072-9. PMID 7595492 DOI: 10.1046/J.1471-4159.1995.65052072.X |
0.401 |
|
| 1994 |
Doyle MP, Linden J, Duling BR. Nucleoside-induced arteriolar constriction: a mast cell-dependent response. The American Journal of Physiology. 266: H2042-50. PMID 8203602 DOI: 10.1152/Ajpheart.1994.266.5.H2042 |
0.355 |
|
| 1994 |
Sawmiller DR, Linden J, Berne RM. Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations. Cardiovascular Research. 28: 604-9. PMID 8025903 DOI: 10.1093/Cvr/28.5.604 |
0.41 |
|
| 1994 |
Linden J. Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions. Trends in Pharmacological Sciences. 15: 298-306. PMID 7940998 DOI: 10.1016/0165-6147(94)90011-6 |
0.496 |
|
| 1993 |
Tucker AL, Linden J. Cloned receptors and cardiovascular responses to adenosine Cardiovascular Research. 27: 62-67. PMID 8458033 DOI: 10.1093/Cvr/27.1.62 |
0.482 |
|
| 1993 |
Shen MR, Linden J, Chen SS, Wu SN. Identification of adenosine receptors in human spermatozoa. Clinical and Experimental Pharmacology & Physiology. 20: 527-34. PMID 8403534 DOI: 10.1111/J.1440-1681.1993.Tb01736.X |
0.409 |
|
| 1993 |
Musser B, Morgan ME, Leid M, Murray TF, Linden J, Vestal RE. Species comparison of adenosine and beta-adrenoceptors in mammalian atrial and ventricular myocardium. European Journal of Pharmacology. 246: 105-11. PMID 8397091 DOI: 10.1016/0922-4106(93)90086-O |
0.431 |
|
| 1993 |
Salvatore CA, Jacobson MA, Taylor HE, Linden J, Johnson RG. Molecular cloning and characterization of the human A3 adenosine receptor. Proceedings of the National Academy of Sciences of the United States of America. 90: 10365-9. PMID 8234299 DOI: 10.1073/Pnas.90.21.10365 |
0.505 |
|
| 1993 |
Shen MR, Linden J, Chiang PH, Chen SS, Wu SN. Adenosine stimulates human sperm motility via A2 receptors. The Journal of Pharmacy and Pharmacology. 45: 650-3. PMID 8105063 DOI: 10.1111/J.2042-7158.1993.Tb05671.X |
0.423 |
|
| 1993 |
Matherne GP, Lloyd TR, Linden J. 2 Ontogeny of myocardial adenosine A1 receptors in the developing rat American Journal of Cardiology. 72: 497. DOI: 10.1016/0002-9149(93)91160-J |
0.44 |
|
| 1993 |
Linden J, Tucker AL, Robeva AS, Graber SG, Munshi R. Properties of recombinant adenosine receptors Drug Development Research. 28: 232-236. DOI: 10.1002/Ddr.430280308 |
0.445 |
|
| 1992 |
Linden J, Taylor HE, Feldman MD, Woodward EB, Ayers CR, Ripley ML, Iflah S, Patel A. The precise radioimmunoassay of adenosine: minimization of sample collection artifacts and immunocrossreactivity. Analytical Biochemistry. 201: 246-54. PMID 1632511 DOI: 10.1016/0003-2697(92)90335-5 |
0.328 |
|
| 1992 |
Tucker AL, Linden J, Robeva AS, D'Angelo DD, Lynch KR. Cloning and expression of a bovine adenosine A1 receptor cDNA. Febs Letters. 297: 107-11. PMID 1551415 DOI: 10.1016/0014-5793(92)80338-H |
0.478 |
|
| 1991 |
Linden J, Tucker AL, Lynch KR. Molecular cloning of adenosine A1 and A2 receptors Trends in Pharmacological Sciences. 12: 326-328. PMID 1949201 DOI: 10.1016/0165-6147(91)90589-K |
0.441 |
|
| 1991 |
Linden J. Structure and function of A1 adenosine receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2668-76. PMID 1916091 DOI: 10.1096/Fasebj.5.12.1916091 |
0.488 |
|
| 1991 |
Linden J, Prater MR, Sullivan GW, Johns RA, Patel A. Contamination of adenosine deaminase by superoxide dismutase. Stabilization of endothelium-derived relaxing factor. Biochemical Pharmacology. 41: 273-9. PMID 1846547 DOI: 10.1016/0006-2952(91)90486-O |
0.384 |
|
| 1991 |
Friedman Z, Delahunty TM, Linden J, Campochiaro PA. Human retinal pigment epithelial cells possess V1 vasopressin receptors. Current Eye Research. 10: 811-816. PMID 1665120 DOI: 10.3109/02713689109013876 |
0.343 |
|
| 1991 |
Chevalier RL, Garmey M, Scarborough RM, Linden J, Gomez RA, Peach MJ, Carey RM. Inhibition of ANP clearance receptors and endopeptidase 24.11 in maturing rats American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 260. PMID 1647702 DOI: 10.1152/Ajpregu.1991.260.6.R1218 |
0.307 |
|
| 1990 |
Linden J, Delahunty TM. Receptors that inhibit phosphoinositide breakdown. Trends in Pharmacological Sciences. 10: 114-20. PMID 2556822 DOI: 10.1016/0165-6147(89)90209-5 |
0.414 |
|
| 1990 |
Greenfield LJ, Hackett JT, Linden J. Xenopus oocyte K+ current. II. Adenylyl cyclase-linked receptors on follicle cells. The American Journal of Physiology. 259: C784-91. PMID 2173413 DOI: 10.1152/Ajpcell.1990.259.5.C784 |
0.365 |
|
| 1990 |
Johns RA, Peach MJ, Linden J, Tichotsky A. NG-monomethyl L-arginine inhibits endothelium-derived relaxing factor-stimulated cyclic GMP accumulation in cocultures of endothelial and vascular smooth muscle cells by an action specific to the endothelial cell. Circulation Research. 67: 979-985. PMID 2170053 DOI: 10.1161/01.Res.67.4.979 |
0.337 |
|
| 1990 |
Greenfield LJ, Hackett JT, Linden J. Xenopus oocyte K+ current. I. FSH and adenosine stimulate follicle cell-dependent currents. The American Journal of Physiology. 259: C775-83. PMID 2122736 DOI: 10.1152/Ajpcell.1990.259.5.C775 |
0.346 |
|
| 1990 |
Feldman M, Ayers C, Gordon V, Lehman M, Sabia P, Kauffman K, Ras D, Skalak T, Linden J. Improved methods for measuring adenosine in human blood: Ischemia induced elevation of coronary sinus adenosine Journal of the American College of Cardiology. 15: A13. DOI: 10.1016/0735-1097(90)91771-L |
0.3 |
|
| 1989 |
Delahunty TM, Cronin MJ, Linden J. Regulation of GH3-cell function via adenosine A1 receptors. Inhibition of prolactin release, cyclic AMP production and inositol phosphate generation. The Biochemical Journal. 255: 69-77. PMID 2848512 DOI: 10.1042/Bj2550069 |
0.423 |
|
| 1989 |
Linden J. Adenosine deaminase for removing adenosine: how much is enough? Trends in Pharmacological Sciences. 10: 260-262. PMID 2672469 DOI: 10.1016/0165-6147(89)90021-7 |
0.38 |
|
| 1989 |
Friedman Z, Hackett SF, Linden J, Campochiaro PA. Human retinal pigment epithelial cells in culture possess A2-adenosine receptors. Brain Research. 492: 29-35. PMID 2546654 DOI: 10.1016/0006-8993(89)90885-8 |
0.471 |
|
| 1988 |
Earl CQ, Patel A, Craig RH, Daluge SM, Linden J. Photoaffinity labeling adenosine A1 receptors with an antagonist 125I-labeled aryl azide derivative of 8-phenylxanthine. Journal of Medicinal Chemistry. 31: 752-756. PMID 3351851 DOI: 10.1021/Jm00399A011 |
0.453 |
|
| 1988 |
Linden J, Patel A, Earl CQ, Craig RH, Daluge SM. 125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors. Journal of Medicinal Chemistry. 31: 745-51. PMID 3351850 DOI: 10.1021/Jm00399A010 |
0.452 |
|
| 1987 |
Earl CQ, Linden J, Weglicki WB. Biochemical mechanisms for the inotropic effect of the cardiotonic drug milrinone. Journal of Cardiovascular Pharmacology. 8: 864-872. PMID 2427830 DOI: 10.1097/00005344-198709010-00031 |
0.351 |
|
| 1982 |
Belardinelli L, Vogel S, Linden J, Berne RM. Antiadrenergic action of adenosine on ventricular myocardium in embryonic chick hearts. Journal of Molecular and Cellular Cardiology. 14: 291-4. PMID 6290675 DOI: 10.1016/0022-2828(82)90207-3 |
0.319 |
|
| 1980 |
Terasaki WL, Linden J, Brooker G. Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist. Proceedings of the National Academy of Sciences of the United States of America. 76: 6401-5. PMID 42915 DOI: 10.1073/Pnas.76.12.6401 |
0.391 |
|
| 1978 |
Linden J, Brooker G. The Positive Inotropic Action of Sulfonylureas: A Mechanism Independent of Cyclic Adenosine 3',5'-Monophosphate Diabetes. 27: 694-698. PMID 207609 DOI: 10.2337/Diab.27.6.694 |
0.304 |
|
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