Kenneth E. Thummel - Publications

University of Washington, Seattle, Seattle, WA 
Pharmacy, Pharmacology, Molecular Biology

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Fohner AE, Dalton R, Skagen K, Jackson K, Claw KG, Hopkins SE, Robinson R, Khan BA, Prasad B, Schuetz EG, Nickerson DA, Thornton TA, Dillard DA, Boyer BB, Thummel KE, et al. Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function. Clinical and Translational Science. PMID 33503331 DOI: 10.1111/cts.12970  0.44
2020 Nguyen JT, Tian DD, Tanna RS, Hadi DL, Bansal S, Calamia JC, Arian CM, Shireman LM, Molnár B, Horváth M, Kellogg JJ, Layton ME, White JR, Cech NB, Boyce RD, ... ... Thummel KE, et al. Assessing Transporter-Mediated Natural Product-Drug Interactions via In vitro-In vivo Extrapolation: Clinical Evaluation with a Probe Cocktail. Clinical Pharmacology and Therapeutics. PMID 33174626 DOI: 10.1002/cpt.2107  0.52
2020 Hsu S, Zelnick LR, Lin YS, Best CM, Kestenbaum B, Thummel KE, Rose LM, Hoofnagle AN, de Boer IH. Differences in 25-Hydroxyvitamin D Clearance by eGFR and Race: A Pharmacokinetic Study. Journal of the American Society of Nephrology : Jasn. PMID 33115916 DOI: 10.1681/ASN.2020050625  0.96
2020 Zhang H, Wolford C, Basit A, Li AP, Fan PW, Takahashi RH, Khojasteh SC, Smith BJ, Murray BP, Thummel K, Prasad B. Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 32350063 DOI: 10.1124/Dmd.120.090738  0.44
2020 Jolliffe DA, Stefanidis C, Wang Z, Kermani NZ, Dimitrov V, White JH, McDonough JE, Janssens W, Pfeffer P, Griffiths CJ, Bush A, Guo Y, Christenson S, Adcock IM, Chung KF, ... Thummel KE, et al. Vitamin D Metabolism is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. PMID 32186892 DOI: 10.1164/Rccm.201909-1867Oc  0.36
2020 Basit A, Prasad B, Estergreen JK, Sabath DE, Alade N, Veenstra D, Rettie AE, Thummel K. A novel LC-MS/MS assay for quantification of des-carboxy prothrombin and characterization of warfarin induced changes. Clinical and Translational Science. PMID 32004415 DOI: 10.1111/Cts.12757  0.44
2020 Liao MZ, Flood Nichols SK, Ahmed M, Clark S, Hankins GD, Caritis S, Venkataramanan R, Haas D, Quinney SK, Haneline LS, Tita AT, Manuck T, Wang J, Thummel KE, Brown LM, et al. Effects of Pregnancy on the Pharmacokinetics of Metformin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31980499 DOI: 10.1124/Dmd.119.088435  0.44
2020 Basit A, Estergreen JK, Sabath DE, Veenstra D, Hopkins S, Boyer B, Rettie A, Thummel K, Prasad B. P195 - A novel LC-MS/MS method for pivkaii quantification: Characterization of warfarin induced altered prothrombin des-carboxylation Drug Metabolism and Pharmacokinetics. 35. DOI: 10.1016/J.Dmpk.2020.04.196  0.44
2019 Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, et al. Pharmacodynamics of glyburide, metformin and glyburide/metformin combination therapy in the treatment of gestational diabetes mellitus. Clinical Pharmacology and Therapeutics. PMID 31869430 DOI: 10.1002/Cpt.1749  0.32
2019 Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, et al. Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus. Journal of Clinical Pharmacology. PMID 31742716 DOI: 10.1002/Jcph.1549  0.32
2019 Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Hong Wong L, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, ... ... Thummel KE, et al. Interrogation of CYP2D6 structural variant alleles improves the correlation between CYP2D6 genotype and CYP2D6-mediated metabolic activity. Clinical and Translational Science. PMID 31536170 DOI: 10.1111/Cts.12695  0.44
2019 Yin J, Wagner DJ, Prasad B, Isoherranen N, Thummel KE, Wang J. Renal Secretion of Hydrochlorothiazide Involves Organic Anion Transporter 1/3, Organic Cation Transporter 2, and Multidrug and Toxin Extrusion Protein 2-K. American Journal of Physiology. Renal Physiology. PMID 31322418 DOI: 10.1152/Ajprenal.00141.2019  0.52
2019 Martineau AR, Thummel KE, Wang Z, Jolliffe DA, Boucher BJ, Griffin SJ, Forouhi NG, Hitman GA. Differential effects of oral boluses of vitamin D2 versus vitamin D3 on vitamin D metabolism: a randomized controlled trial. The Journal of Clinical Endocrinology and Metabolism. PMID 31199458 DOI: 10.1210/Jc.2019-00207  0.36
2018 Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE. Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system. Altex. PMID 29999169 DOI: 10.14573/Altex.1803161  0.32
2018 Ryu RJ, Easterling TR, Caritis SN, Venkataramanan R, Umans JG, Ahmed MS, Clark S, Kantrowitz-Gordon I, Hays K, Bennett B, Honaker MT, Thummel KE, Shen DD, Hebert MF. Prednisone Pharmacokinetics During Pregnancy and Lactation. Journal of Clinical Pharmacology. PMID 29733485 DOI: 10.1002/Jcph.1122  0.32
2018 Gao C, Liao MZ, Han LW, Thummel KE, Mao Q. Hepatic transport of 25-hydroxyvitamin Dconjugates: a mechanism of 25-hydroxyvitamin Ddelivery to the intestinal tract. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29467214 DOI: 10.1124/Dmd.117.078881  0.36
2018 Wong T, Wang Z, Chapron BD, Suzuki M, Claw KG, Gao C, Foti RS, Prasad B, Chapron A, Calamia J, Chaudhry A, Schuetz EG, Horst RL, Mao Q, de Boer IH, ... ... Thummel KE, et al. Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-sulfate, A Major Circulating Vitamin D Metabolite in Humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29343609 DOI: 10.1124/Dmd.117.078428  0.44
2018 Tanner JA, Zhu AZ, Claw KG, Prasad B, Korchina V, Hu J, Doddapaneni H, Muzny DM, Schuetz EG, Lerman C, Thummel KE, Scherer SE, Tyndale RF. Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenetics and Genomics. 28: 7-16. PMID 29232328 DOI: 10.1097/Fpc.0000000000000317  0.44
2017 Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson D, Schuetz E, Rettie AE, Leeder S, Thummel KE, Prasad B. Genetic and Non-genetic Factors Associated with Protein Abundance of Flavin-containing Monooxygenase 3 in Human Liver. The Journal of Pharmacology and Experimental Therapeutics. PMID 28819071 DOI: 10.1124/Jpet.117.243113  0.44
2017 Gao C, Bergagnini-Kolev MC, Liao MZ, Wang Z, Wong T, Calamia JC, Lin YS, Mao Q, Thummel KE. Simultaneous quantification of 25-hydroxyvitamin D3-3-sulfate and 25-hydroxyvitamin D3-3-glucuronide in human serum and plasma using liquid chromatography-tandem mass spectrometry coupled with DAPTAD-derivatization. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1060: 158-165. PMID 28622619 DOI: 10.1016/J.Jchromb.2017.06.017  0.96
2016 Tanner JA, Prasad B, Claw KG, Stapleton P, Chaudhry A, Schuetz EG, Thummel KE, Tyndale RF. Predictors of variation in CYP2A6 mRNA, protein, and enzyme activity in a human liver bank: influence of genetic and non-genetic factors. The Journal of Pharmacology and Experimental Therapeutics. PMID 27815364 DOI: 10.1124/Jpet.116.237594  0.44
2016 Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney International. 90: 627-37. PMID 27521113 DOI: 10.1016/J.Kint.2016.06.011  0.36
2016 O'Brien DM, Thummel KE, Bulkow LR, Wang Z, Corbin B, Klejka J, Hopkins SE, Boyer BB, Hennessy TW, Singleton R. Declines in traditional marine food intake and vitamin D levels from the 1960s to present in young Alaska Native women. Public Health Nutrition. 1-8. PMID 27465921 DOI: 10.1017/S1368980016001853  0.36
2016 Dorfman EH, Cheng EY, Hebert MF, Thummel KE, Burke W. Prenatal pharmacogenomics: a promising area for research. The Pharmacogenomics Journal. PMID 27168097 DOI: 10.1038/Tpj.2016.33  0.52
2015 Yamaura Y, Chapron BD, Wang Z, Himmelfarb J, Thummel KE. Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26700954 DOI: 10.1124/Dmd.115.068429  0.36
2015 Tracy TS, Chaudhry AS, Prasad B, Thummel KE, Schuetz EG, Zhong XB, Tien YC, Jeong H, Pan X, Shireman LM, Tay-Sontheimer J, Lin YS. Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26681736 DOI: 10.1124/Dmd.115.067900  0.96
2015 Ryman TK, Boyer BB, Hopkins S, Philip J, Beresford SA, Thompson B, Heagerty PJ, Pomeroy JJ, Thummel KE, Austin MA. Associations between diet and cardiometabolic risk among Yup'ik Alaska Native people using food frequency questionnaire dietary patterns. Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd. PMID 26607703 DOI: 10.1016/J.Numecd.2015.08.003  0.52
2015 Ryu RJ, Eyal S, Easterling TR, Caritis SN, Venkataraman R, Hankins G, Rytting E, Thummel K, Kelly EJ, Risler L, Phillips B, Honaker MT, Shen DD, Hebert MF. Pharmacokinetics of metoprolol during pregnancy and lactation. Journal of Clinical Pharmacology. PMID 26461463 DOI: 10.1002/Jcph.631  0.52
2015 Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE. Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content. The Pharmacogenomics Journal. PMID 26323597 DOI: 10.1038/Tpj.2015.58  0.52
2015 Chaudhry AS, Prasad B, Shirasaka Y, Fohner A, Finkelstein D, Fan Y, Wang S, Wu G, Aklillu E, Sim SC, Thummel KE, Schuetz EG. The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1226-35. PMID 26021325 DOI: 10.1124/Dmd.115.064428  0.52
2015 Vyhlidal CA, Pearce RE, Gaedigk R, Calamia JC, Shuster DL, Thummel KE, Leeder JS. Variability in Expression of CYP3A5 in Human Fetal Liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 25979262 DOI: 10.1124/Dmd.115.064998  0.52
2015 Fohner AE, Robinson R, Yracheta J, Dillard DA, Schilling B, Khan B, Hopkins S, Boyer BB, Black J, Wiener H, Tiwari HK, Gordon A, Nickerson D, Tsai JM, Farin FM, ... ... Thummel KE, et al. Variation in genes controlling warfarin disposition and response in American Indian and Alaska Native people: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX. Pharmacogenetics and Genomics. 25: 343-53. PMID 25946405 DOI: 10.1097/Fpc.0000000000000143  0.52
2015 Chapron B, Risler L, Phillips B, Collins C, Thummel K, Shen D. Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, SociéTé Canadienne Des Sciences Pharmaceutiques. 18: 101-11. PMID 25877445 DOI: 10.18433/J3288C  0.52
2015 Roth JA, Bradley K, Thummel KE, Veenstra DL, Boudreau D. Alcohol misuse, genetics, and major bleeding among warfarin therapy patients in a community setting. Pharmacoepidemiology and Drug Safety. 24: 619-27. PMID 25858232 DOI: 10.1002/Pds.3769  0.52
2015 Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, Wang D, Vinks AA, He Y, Swen JJ, Leeder JS, van Schaik R, Thummel KE, Klein TE, Caudle KE, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Clinical Pharmacology and Therapeutics. 98: 19-24. PMID 25801146 DOI: 10.1002/Cpt.113  0.52
2015 Ryman TK, Boyer BB, Hopkins S, Philip J, O'Brien D, Thummel K, Austin MA. Characterising the reproducibility and reliability of dietary patterns among Yup'ik Alaska Native people. The British Journal of Nutrition. 113: 634-43. PMID 25656871 DOI: 10.1017/S0007114514003596  0.52
2015 Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE. Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content Pharmacogenomics Journal. DOI: 10.1038/tpj.2015.58  0.52
2014 Tay-Sontheimer J, Shireman LM, Beyer RP, Senn T, Witten D, Pearce RE, Gaedigk A, Gana Fomban CL, Lutz JD, Isoherranen N, Thummel KE, Fiehn O, Leeder JS, Lin YS. Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics. Pharmacogenomics. 15: 1947-62. PMID 25521354 DOI: 10.2217/Pgs.14.155  0.52
2014 Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochemical Pharmacology. 92: 690-700. PMID 25450675 DOI: 10.1016/J.Bcp.2014.09.025  0.52
2014 Woodahl EL, Lesko LJ, Hopkins S, Robinson RF, Thummel KE, Burke W. Pharmacogenetic research in partnership with American Indian and Alaska Native communities. Pharmacogenomics. 15: 1235-41. PMID 25141898 DOI: 10.2217/Pgs.14.91  0.52
2014 Shuster DL, Risler LJ, Liang CK, Rice KM, Shen DD, Hebert MF, Thummel KE, Mao Q. Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age. The Journal of Pharmacology and Experimental Therapeutics. 350: 425-34. PMID 24898265 DOI: 10.1124/Jpet.114.213470  0.52
2014 de Boer IH, Sachs MC, Chonchol M, Himmelfarb J, Hoofnagle AN, Ix JH, Kremsdorf RA, Lin YS, Mehrotra R, Robinson-Cohen C, Siscovick DS, Steffes MW, Thummel KE, Tracy RP, Wang Z, et al. Estimated GFR and circulating 24,25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 64: 187-97. PMID 24703961 DOI: 10.1053/J.Ajkd.2014.02.015  0.52
2014 Wang Z, Wong T, Hashizume T, Dickmann LZ, Scian M, Koszewski NJ, Goff JP, Horst RL, Chaudhry AS, Schuetz EG, Thummel KE. Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability. Endocrinology. 155: 2052-63. PMID 24641623 DOI: 10.1210/En.2013-2013  0.44
2014 Thummel KE, Lin YS. Sources of interindividual variability. Methods in Molecular Biology (Clifton, N.J.). 1113: 363-415. PMID 24523121 DOI: 10.1007/978-1-62703-758-7_17  0.96
2014 Roth JA, Boudreau D, Fujii MM, Farin FM, Rettie AE, Thummel KE, Veenstra DL. Genetic risk factors for major bleeding in patients treated with warfarin in a community setting. Clinical Pharmacology and Therapeutics. 95: 636-43. PMID 24503627 DOI: 10.1038/Clpt.2014.26  0.52
2014 Barr JT, Choughule KV, Nepal S, Wong T, Chaudhry AS, Joswig-Jones CA, Zientek M, Strom SC, Schuetz EG, Thummel KE, Jones JP. Why do most human liver cytosol preparations lack xanthine oxidase activity? Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 695-9. PMID 24430612 DOI: 10.1124/Dmd.113.056374  0.52
2014 Yeung CK, Shen DD, Thummel KE, Himmelfarb J. Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. Kidney International. 85: 522-8. PMID 24132209 DOI: 10.1038/Ki.2013.399  0.52
2014 Ryman TK, Austin MA, Hopkins S, Philip J, O'Brien D, Thummel K, Boyer BB. Using exploratory factor analysis of FFQ data to identify dietary patterns among Yup'ik people. Public Health Nutrition. 17: 510-8. PMID 23290469 DOI: 10.1017/S1368980012005411  0.52
2013 Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, et al. Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. Stem Cell Research & Therapy. 4: S17. PMID 24564863 DOI: 10.1186/Scrt378  0.52
2013 Fohner A, Muzquiz LI, Austin MA, Gaedigk A, Gordon A, Thornton T, Rieder MJ, Pershouse MA, Putnam EA, Howlett K, Beatty P, Thummel KE, Woodahl EL. Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes. Pharmacogenetics and Genomics. 23: 403-14. PMID 23778323 DOI: 10.1097/Fpc.0B013E3283629Ce9  0.52
2013 Shirasaka Y, Chang SY, Grubb MF, Peng CC, Thummel KE, Isoherranen N, Rodrigues AD. Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1566-74. PMID 23723360 DOI: 10.1124/Dmd.112.049940  0.52
2013 Zheng S, Easterling TR, Hays K, Umans JG, Miodovnik M, Clark S, Calamia JC, Thummel KE, Shen DD, Davis CL, Hebert MF. Tacrolimus placental transfer at delivery and neonatal exposure through breast milk. British Journal of Clinical Pharmacology. 76: 988-96. PMID 23528073 DOI: 10.1111/Bcp.12122  0.52
2013 Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD, Thummel KE. CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition. Transplantation. 95: 821-7. PMID 23354298 DOI: 10.1097/Tp.0B013E31827E6Ad9  0.52
2013 Isoherranen N, Thummel KE. Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes? Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 256-62. PMID 23328895 DOI: 10.1124/Dmd.112.050245  0.52
2013 Hebert MF, Zheng S, Hays K, Shen DD, Davis CL, Umans JG, Miodovnik M, Thummel KE, Easterling TR. Interpreting tacrolimus concentrations during pregnancy and postpartum. Transplantation. 95: 908-15. PMID 23274970 DOI: 10.1097/Tp.0B013E318278D367  0.52
2013 Wang Z, Lin YS, Dickmann LJ, Poulton EJ, Eaton DL, Lampe JW, Shen DD, Davis CL, Shuhart MC, Thummel KE. Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: implications for drug-induced osteomalacia. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 1101-16. PMID 23212742 DOI: 10.1002/Jbmr.1839  0.52
2013 Shuster DL, Bammler TK, Beyer RP, Macdonald JW, Tsai JM, Farin FM, Hebert MF, Thummel KE, Mao Q. Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 332-42. PMID 23175668 DOI: 10.1124/Dmd.112.049718  0.52
2013 Poulton EJ, Levy L, Lampe JW, Shen DD, Tracy J, Shuhart MC, Thummel KE, Eaton DL. Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo. Toxicology and Applied Pharmacology. 266: 122-31. PMID 23153560 DOI: 10.1016/J.Taap.2012.10.029  0.52
2013 Baker PE, Cole TB, Cartwright M, Suzuki SM, Thummel KE, Lin YS, Co AL, Rettie AE, Kim JH, Furlong CE. Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants. Chemico-Biological Interactions. 203: 257-64. PMID 23085349 DOI: 10.1016/J.Cbi.2012.10.005  0.52
2013 Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. The Journal of Steroid Biochemistry and Molecular Biology. 136: 54-8. PMID 22985909 DOI: 10.1016/J.Jsbmb.2012.09.012  0.44
2013 Witt K, Jolliffe D, Wang Z, Thummel K, Timms P, Griffiths C, Martineau A. P90 Vitamin D status improves following recovery from tuberculosis Thorax. 68. DOI: 10.1136/Thoraxjnl-2013-204457.240  0.36
2012 Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD, Thummel KE. Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition. Clinical Pharmacology and Therapeutics. 92: 737-45. PMID 23073208 DOI: 10.1038/Clpt.2012.175  0.52
2012 Zheng S, Easterling TR, Umans JG, Miodovnik M, Calamia JC, Thummel KE, Shen DD, Davis CL, Hebert MF. Pharmacokinetics of tacrolimus during pregnancy. Therapeutic Drug Monitoring. 34: 660-70. PMID 23007747 DOI: 10.1097/Ftd.0B013E3182708Edf  0.52
2012 Laha TJ, Strathmann FG, Wang Z, de Boer IH, Thummel KE, Hoofnagle AN. Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry. Clinical Chemistry. 58: 1711-6. PMID 22968104 DOI: 10.1373/Clinchem.2012.185827  0.52
2012 Zheng XE, Wang Z, Liao MZ, Lin YS, Shuhart MC, Schuetz EG, Thummel KE. Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells. Biochemical Pharmacology. 84: 391-401. PMID 22562045 DOI: 10.1016/J.Bcp.2012.04.019  0.96
2012 Thirumaran RK, Lamba JK, Kim RB, Urquhart BL, Gregor JC, Chande N, Fan Y, Qi A, Cheng C, Thummel KE, Hall SD, Schuetz EG. Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation. Biochemical Pharmacology. 84: 104-12. PMID 22484315 DOI: 10.1016/J.Bcp.2012.03.017  0.52
2012 Wang Z, Lin YS, Zheng XE, Senn T, Hashizume T, Scian M, Dickmann LJ, Nelson SD, Baillie TA, Hebert MF, Blough D, Davis CL, Thummel KE. An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway. Molecular Pharmacology. 81: 498-509. PMID 22205755 DOI: 10.1124/Mol.111.076356  0.52
2012 Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 610-6. PMID 22190694 DOI: 10.1124/Dmd.111.042705  0.52
2012 Thirumaran RK, Lamba JK, Kim RB, Urquhart BL, Gregor JC, Chande N, Fan Y, Thummel KE, Hall SD, Schuetz EG. Intestinal CYP3A4 and midazolam disposition in vivo show seasonal variation and associate with VDR polymorphisms F1000research. 3. DOI: 10.7490/F1000Research.1089481.1  0.44
2011 Kirby BJ, Collier AC, Kharasch ED, Dixit V, Desai P, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2329-37. PMID 21930825 DOI: 10.1124/Dmd.111.038646  0.52
2011 Wang Z, Senn T, Kalhorn T, Zheng XE, Zheng S, Davis CL, Hebert MF, Lin YS, Thummel KE. Simultaneous measurement of plasma vitamin D(3) metabolites, including 4β,25-dihydroxyvitamin D(3), using liquid chromatography-tandem mass spectrometry. Analytical Biochemistry. 418: 126-33. PMID 21784054 DOI: 10.1016/J.Ab.2011.06.043  0.96
2011 Innocenti F, Cooper GM, Stanaway IB, Gamazon ER, Smith JD, Mirkov S, Ramirez J, Liu W, Lin YS, Moloney C, Aldred SF, Trinklein ND, Schuetz E, Nickerson DA, Thummel KE, et al. Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. Plos Genetics. 7: e1002078. PMID 21637794 DOI: 10.1371/Journal.Pgen.1002078  0.52
2011 Peng CC, Templeton I, Thummel KE, Davis C, Kunze KL, Isoherranen N. Evaluation of 6β-hydroxycortisol, 6β-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo. Clinical Pharmacology and Therapeutics. 89: 888-95. PMID 21490593 DOI: 10.1038/Clpt.2011.53  0.52
2011 Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1070-8. PMID 21406602 DOI: 10.1124/Dmd.110.037523  0.52
2010 Templeton I, Peng CC, Thummel KE, Davis C, Kunze KL, Isoherranen N. Accurate prediction of dose-dependent CYP3A4 inhibition by itraconazole and its metabolites from in vitro inhibition data. Clinical Pharmacology and Therapeutics. 88: 499-505. PMID 20739919 DOI: 10.1038/Clpt.2010.119  0.52
2010 Suresh BN, Lin YS, Rieder MJ, Marciante KD, Psaty BM, Thummel KE, Totah RA. Human liver expression of CYP2C8: Gender, age, and genotype effects Drug Metabolism and Disposition. 38: 889-893. PMID 20190184 DOI: 10.1124/Dmd.109.031542  0.52
2010 Yeung CK, Zhao P, Shen DD, Thummel KE. Drug disposition and drug-drug interactions: Importance of first-pass metabolism in gut and liver Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges. 415-435. DOI: 10.1007/978-1-4419-0840-7_17  0.52
2009 Salinger DH, Shen DD, Thummel K, Wittkowsky AK, Vicini P, Veenstra DL. Pharmacogenomic trial design: use of a PK/PD model to explore warfarin dosing interventions through clinical trial simulation. Pharmacogenetics and Genomics. 19: 965-71. PMID 19881396 DOI: 10.1097/Fpc.0B013E3283333B80  0.52
2009 Reding KW, Li CI, Weiss NS, Chen C, Carlson CS, Duggan D, Thummel KE, Daling JR, Malone KE. Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk American Journal of Epidemiology. 170: 1241-1249. PMID 19846565 DOI: 10.1093/Aje/Kwp298  0.52
2009 Reding KW, Weiss NS, Chen C, Li CI, Carlson CS, Wilkerson HW, Farin FM, Thummel KE, Daling JR, Malone KE. Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 1461-7. PMID 19383894 DOI: 10.1158/1055-9965.Epi-08-0917  0.52
2009 Zhao P, Ragueneau-Majlessi I, Zhang L, Strong JM, Reynolds KS, Levy RH, Thummel KE, Huang SM. Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole: a simulation study. Journal of Clinical Pharmacology. 49: 351-9. PMID 19246732 DOI: 10.1177/0091270008331196  0.52
2009 McConn DJ, Lin YS, Mathisen TL, Blough DK, Xu Y, Hashizume T, Taylor SL, Thummel KE, Shuhart MC. Reduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis. Clinical Pharmacology and Therapeutics. 85: 387-93. PMID 19212316 DOI: 10.1038/Clpt.2008.292  0.96
2009 Zhang Y, Zhang L, Abraham S, Apparaju S, Wu TC, Strong JM, Xiao S, Atkinson AJ, Thummel KE, Leeder JS, Lee C, Burckart GJ, Lesko LJ, Huang SM. Assessment of the impact of renal impairment on systemic exposure of new molecular entities: Evaluation of recent new drug applications Clinical Pharmacology and Therapeutics. 85: 305-311. PMID 19020495 DOI: 10.1038/clpt.2008.208  0.52
2008 Smith HE, Jones JP, Kalhorn TF, Farin FM, Stapleton PL, Davis CL, Perkins JD, Blough DK, Hebert MF, Thummel KE, Totah RA. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. Pharmacogenetics and Genomics. 18: 943-53. PMID 18769365 DOI: 10.1097/Fpc.0B013E32830E1E16  0.52
2008 Huang SM, Strong JM, Zhang L, Reynolds KS, Nallani S, Temple R, Abraham S, Habet SA, Baweja RK, Burckart GJ, Chung S, Colangelo P, Frucht D, Green MD, Hepp P, ... ... Thummel K, et al. New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process. Journal of Clinical Pharmacology. 48: 662-70. PMID 18378963 DOI: 10.1177/0091270007312153  0.52
2008 Totah RA, Sheffels P, Roberts T, Whittington D, Thummel K, Kharasch ED. Role of CYP2B6 in stereoselective human methadone metabolism. Anesthesiology. 108: 363-74. PMID 18292673 DOI: 10.1097/Aln.0B013E3181642938  0.52
2008 Hebert MF, Easterling TR, Kirby B, Carr DB, Buchanan ML, Rutherford T, Thummel KE, Fishbein DP, Unadkat JD. Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study. Clinical Pharmacology and Therapeutics. 84: 248-53. PMID 18288078 DOI: 10.1038/Clpt.2008.1  0.52
2008 Poonkuzhali B, Lamba J, Strom S, Sparreboom A, Thummel K, Watkins P, Schuetz E. Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 780-95. PMID 18180275 DOI: 10.1124/Dmd.107.018366  0.52
2008 Hashizume T, Xu Y, Mohutsky MA, Alberts J, Hadden C, Kalhorn TF, Isoherranen N, Shuhart MC, Thummel KE. Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation. Biochemical Pharmacology. 75: 1240-50. PMID 18177842 DOI: 10.1016/J.Bcp.2007.11.008  0.52
2008 Isoherranen N, Ludington SR, Givens RC, Lamba JK, Pusek SN, Dees EC, Blough DK, Iwanaga K, Hawke RL, Schuetz EG, Watkins PB, Thummel KE, Paine MF. The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 146-54. PMID 17954524 DOI: 10.1124/Dmd.107.018382  0.52
2008 Templeton IE, Thummel KE, Kharasch ED, Kunze KL, Hoffer C, Nelson WL, Isoherranen N. Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. Clinical Pharmacology and Therapeutics. 83: 77-85. PMID 17495874 DOI: 10.1038/Sj.Clpt.6100230  0.52
2007 Huang W, Kalhorn TF, Baillie M, Shen DD, Thummel KE. Determination of free and total cortisol in plasma and urine by liquid chromatography-tandem mass spectrometry. Therapeutic Drug Monitoring. 29: 215-24. PMID 17417077 DOI: 10.1097/Ftd.0B013E31803D14C0  0.52
2007 Zhou C, Poulton EJ, Grün F, Bammler TK, Blumberg B, Thummel KE, Eaton DL. The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Molecular Pharmacology. 71: 220-9. PMID 17028159 DOI: 10.1124/Mol.106.029264  0.32
2006 Zhou C, Tabb MM, Nelson EL, Grün F, Verma S, Sadatrafiei A, Lin M, Mallick S, Forman BM, Thummel KE, Blumberg B. Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. The Journal of Clinical Investigation. 116: 2280-2289. PMID 16841097 DOI: 10.1172/Jci26283  0.52
2006 Xu Y, Iwanaga K, Zhou C, Cheesman MJ, Farin F, Thummel KE. Selective induction of intestinal CYP3A23 by 1alpha,25-dihydroxyvitamin D3 in rats. Biochemical Pharmacology. 72: 385-92. PMID 16769037 DOI: 10.1016/J.Bcp.2006.04.033  0.52
2006 Zhou C, Assem M, Tay JC, Watkins PB, Blumberg B, Schuetz EG, Thummel KE. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. The Journal of Clinical Investigation. 116: 1703-12. PMID 16691293 DOI: 10.1172/Jci27793  0.44
2006 Lamba J, Strom S, Venkataramanan R, Thummel KE, Lin YS, Liu W, Cheng C, Lamba V, Watkins PB, Schuetz E. MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype. Clinical Pharmacology and Therapeutics. 79: 325-38. PMID 16580901 DOI: 10.1016/J.Clpt.2005.11.013  0.52
2006 Dai Y, Hebert MF, Isoherranen N, Davis CL, Marsh C, Shen DD, Thummel KE. Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 836-47. PMID 16501005 DOI: 10.1124/Dmd.105.008680  0.52
2006 Kunze KL, Nelson WL, Kharasch ED, Thummel KE, Isoherranen N. Stereochemical aspects of itraconazole metabolism in vitro and in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 583-90. PMID 16415110 DOI: 10.1124/Dmd.105.008508  0.52
2006 Gupta A, Dai Y, Vethanayagam RR, Hebert MF, Thummel KE, Unadkat JD, Ross DD, Mao Q. Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemotherapy and Pharmacology. 58: 374-83. PMID 16404634 DOI: 10.1007/S00280-005-0173-6  0.36
2006 Xu Y, Hashizume T, Shuhart MC, Davis CL, Nelson WL, Sakaki T, Kalhorn TF, Watkins PB, Schuetz EG, Thummel KE. Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Molecular Pharmacology. 69: 56-65. PMID 16207822 DOI: 10.1124/Mol.105.017392  0.52
2006 Yeung CK, Rettie AE, Thummel KE. Polymorphisms in Cytochrome P450 and Flavin-Containing Monooxygenase Genes Gene-Environment Interactions: Fundamentals of Ecogenetics. 95-126. DOI: 10.1002/0471758043.ch7  0.52
2005 Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM, Ratain MJ, Thummel K. Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests. Clinical Pharmacology and Therapeutics. 78: 559-81. PMID 16338273 DOI: 10.1016/J.Clpt.2005.08.013  0.52
2005 Kharasch ED, Thummel KE, Watkins PB. CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition. Molecular Interventions. 5: 151-3. PMID 15994453 DOI: 10.1124/Mi.5.3.3  0.4
2005 Rieder MJ, Reiner AP, Gage BF, Nickerson DA, Eby CS, McLeod HL, Blough DK, Thummel KE, Veenstra DL, Rettie AE. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. The New England Journal of Medicine. 352: 2285-93. PMID 15930419 DOI: 10.1056/Nejmoa044503  0.52
2005 McCune JS, Risler LJ, Phillips BR, Thummel KE, Blough D, Shen DD. Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1074-81. PMID 15821045 DOI: 10.1124/Dmd.104.002279  0.52
2004 Dai Y, Iwanaga K, Lin YS, Hebert MF, Davis CL, Huang W, Kharasch ED, Thummel KE. In vitro metabolism of cyclosporine A by human kidney CYP3A5 Biochemical Pharmacology. 68: 1889-1902. PMID 15450954 DOI: 10.1016/J.Bcp.2004.07.012  0.52
2004 Huang W, Lin YS, McConn DJ, Calamia JC, Totah RA, Isoherranen N, Glodowski M, Thummel KE. Evidence of significant contribution from CYP3A5 to hepatic drug metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1434-45. PMID 15383492 DOI: 10.1124/Dmd.104.001313  0.52
2004 McConn DJ, Lin YS, Allen K, Kunze KL, Thummel KE. Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1083-91. PMID 15377640 DOI: 10.1124/Dmd.32.10.1083  0.96
2004 Isoherranen N, Kunze KL, Allen KE, Nelson WL, Thummel KE. Role of itraconazole metabolites in CYP3A4 inhibition. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1121-31. PMID 15242978 DOI: 10.1124/Dmd.104.000315  0.52
2004 Schuetz EG, Relling MV, Kishi S, Yang W, Das S, Chen P, Cook EH, Rosner GL, Pui CH, Blanco JG, Edick MJ, Hancock ML, Winick NJ, Dervieux T, Amylon MD, ... ... Thummel K, et al. PharmGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5. Pharmacological Reviews. 56: 159. PMID 15169924 DOI: 10.1124/Pr.56.2.1  0.52
2004 McConnachie L, Bodor M, Kowdley K, Levy A, Tung B, Thummel K, Phillips B, Bajpai M, Chi V, Esmay JD, Shen DD, Ho RJ. Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate. Clinical Pharmacology and Therapeutics. 75: 282-97. PMID 15060507 DOI: 10.1016/J.Clpt.2003.12.003  0.52
2003 Hebert MF, Dowling AL, Gierwatowski C, Lin YS, Edwards KL, Davis CL, Marsh CL, Schuetz EG, Thummel KE. Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors. Pharmacogenetics. 13: 661-74. PMID 14583679 DOI: 10.1097/00008571-200311000-00002  0.52
2003 Park JM, Lin YS, Calamia JC, Thummel KE, Slattery JT, Kalhorn TF, Carithers RL, Levy AE, Marsh CL, Hebert MF. Transiently altered acetaminophen metabolism after liver transplantation. Clinical Pharmacology and Therapeutics. 73: 545-53. PMID 12811364 DOI: 10.1016/S0009-9236(03)00062-6  0.52
2003 Givens RC, Lin YS, Dowling AL, Thummel KE, Lamba JK, Schuetz EG, Stewart PW, Watkins PB. CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 1297-300. PMID 12754175 DOI: 10.1152/Japplphysiol.00322.2003  0.52
2003 Carcillo JA, Adedoyin A, Burckart GJ, Frye RF, Venkataramanan R, Knoll C, Thummel K, Roskos L, Wilson JW, Sereika S, Romkes M, Bebia Z, Branch RA. Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation. Clinical Pharmacology and Therapeutics. 73: 456-67. PMID 12732845 DOI: 10.1016/S0009-9236(03)00055-9  0.52
2003 Rettie AE, Tai G, Veenstra DL, Farin FM, Srinouanprachan S, Lin YS, Thummel KE, Hines RN. CYP2C9 exon 4 mutations and warfarin dose phenotype in Asians. Blood. 101: 2896-7. PMID 12642346 DOI: 10.1182/Blood-2002-11-3452  0.52
2003 Zamber CP, Lamba JK, Yasuda K, Farnum J, Thummel K, Schuetz JD, Schuetz EG. Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. Pharmacogenetics. 13: 19-28. PMID 12544509 DOI: 10.1097/00008571-200301000-00004  0.52
2002 Lamba JK, Lin YS, Schuetz EG, Thummel KE. Genetic contribution to variable human CYP3A-mediated metabolism. Advanced Drug Delivery Reviews. 54: 1271-94. PMID 12406645 DOI: 10.1016/S0169-409X(02)00066-2  0.52
2002 Sachdeo RC, Sachdeo SK, Levy RH, Streeter AJ, Bishop FE, Kunze KL, Mather GG, Roskos LK, Shen DD, Thummel KE, Trager WF, Curtin CR, Doose DR, Gisclon LG, Bialer M. Topiramate and phenytoin pharmacokinetics during repetitive monotherapy and combination therapy to epileptic patients. Epilepsia. 43: 691-6. PMID 12102670 DOI: 10.1046/J.1528-1157.2002.41701.X  0.52
2002 Lin YS, Dowling AL, Quigley SD, Farin FM, Zhang J, Lamba J, Schuetz EG, Thummel KE. Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism. Molecular Pharmacology. 62: 162-72. PMID 12065767 DOI: 10.1124/Mol.62.1.162  0.52
2002 Paine MF, Leung LY, Lim HK, Liao K, Oganesian A, Zhang MY, Thummel KE, Watkins PB. Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion. The Journal of Pharmacology and Experimental Therapeutics. 301: 174-86. PMID 11907172 DOI: 10.1124/Jpet.301.1.174  0.4
2002 Lamba JK, Lin YS, Thummel K, Daly A, Watkins PB, Strom S, Zhang J, Schuetz EG. Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics. 12: 121-32. PMID 11875366 DOI: 10.1097/00008571-200203000-00006  0.52
2001 Lin YS, Lockwood GF, Graham MA, Brian WR, Loi CM, Dobrinska MR, Shen DD, Watkins PB, Wilkinson GR, Kharasch ED, Thummel KE. In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration. Pharmacogenetics. 11: 781-91. PMID 11740342 DOI: 10.1097/00008571-200112000-00006  0.52
2001 Thummel KE, Brimer C, Yasuda K, Thottassery J, Senn T, Lin Y, Ishizuka H, Kharasch E, Schuetz J, Schuetz E. Transcriptional control of intestinal cytochrome P-4503A by 1α,25-dihydroxy vitamin D3 Molecular Pharmacology. 60: 1399-1406. PMID 11723248 DOI: 10.1124/Mol.60.6.1399  0.52
2001 Zhang J, Kuehl P, Green ED, Touchman JW, Watkins PB, Daly A, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Wrighton SA, Hancock M, Kim RB, Strom S, ... Thummel K, et al. The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics. 11: 555-72. PMID 11668216 DOI: 10.1097/00008571-200110000-00003  0.52
2001 Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Venkataramanan R, ... ... Thummel K, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nature Genetics. 27: 383-91. PMID 11279519 DOI: 10.1038/86882  0.52
2000 Fisher MB, VandenBranden M, Findlay K, Burchell B, Thummel KE, Hall SD, Wrighton SA. Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: Relationship between UGT1A1 promoter genotype and variability in a liver bank Pharmacogenetics. 10: 727-739. PMID 11186135 DOI: 10.1097/00008571-200011000-00007  0.52
2000 Wrighton SA, Schuetz EG, Thummel KE, Shen DD, Korzekwa KR, Watkins PB. The human CYP3A subfamily: Practical considerations Drug Metabolism Reviews. 32: 339-361. PMID 11139133 DOI: 10.1081/Dmr-100102338  0.52
2000 Paine MF, Davis CL, Shen DD, Marsh CL, Raisys VA, Thummel KE. Can oral midazolam predict oral cyclosporine disposition? European Journal of Pharmaceutical Sciences. 12: 51-62. PMID 11121733 DOI: 10.1016/S0928-0987(00)00139-1  0.52
2000 Thummel KE, Slattery JT, Ro H, Chien JY, Nelson SD, Lown KE, Watkins PB. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults Clinical Pharmacology and Therapeutics. 67: 591-599. PMID 10872641 DOI: 10.1067/Mcp.2000.106574  0.52
2000 Gibbs MA, Baillie MT, Shen DD, Kunze KL, Thummel KE. Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells. Pharmaceutical Research. 17: 299-305. PMID 10801218 DOI: 10.1023/A:1007550717526  0.52
1999 Kinirons MT, O'Shea D, Kim RB, Groopman JD, Thummel KE, Wood AJJ, Wilkinson GR. Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A Clinical Pharmacology and Therapeutics. 66: 224-231. PMID 10511057 DOI: 10.1016/S0009-9236(99)70029-9  0.52
1999 Madani S, Paine MF, Lewis L, Thummel KE, Shen DD. Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines Pharmaceutical Research. 16: 1199-1205. PMID 10468020 DOI: 10.1023/A:1018989211864  0.52
1997 Tran A, Rey E, Pons G, Rousseau M, d'Athis P, Olive G, Mather GG, Bishop FE, Wurden CJ, Labroo R, Trager WF, Kunze KL, Thummel KE, Vincent JC, Gillardin JM, et al. Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivo inhibition constants. Clinical Pharmacology and Therapeutics. 62: 490-504. PMID 9390105 DOI: 10.1016/S0009-9236(97)90044-8  0.52
1997 Schmiedlin-Ren P, Thummel KE, Fisher JM, Paine MF, Lown KS, Watkins PB. Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3. Molecular Pharmacology. 51: 741-54. PMID 9145912 DOI: 10.1124/Mol.51.5.741  0.4
1997 Thummel KE, Kunze KL, Shen DD. Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction Advanced Drug Delivery Reviews. 27: 99-127. DOI: 10.1016/S0169-409X(97)00039-2  0.52
1996 Slattery JT, Nelson SD, Thummel KE. The complex interaction between ethanol and acetaminophen Clinical Pharmacology and Therapeutics. 60: 241-246. PMID 8841146 DOI: 10.1016/S0009-9236(96)90050-8  0.52
1996 Paine MF, Shen DD, Kunze KL, Perkins JD, Marsh CL, McVicar JP, Barr DM, Gillies BS, Thummel KE. First-pass metabolism of midazolam by the human intestine Clinical Pharmacology and Therapeutics. 60: 14-24. PMID 8689807 DOI: 10.1016/S0009-9236(96)90162-9  0.52
1996 Thummel KE, O'Shea D, Paine MF, Shen DD, Kunze KL, Perkins JD, Wilkinson GR. Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism Clinical Pharmacology and Therapeutics. 59: 491-502. PMID 8646820 DOI: 10.1016/S0009-9236(96)90177-0  0.52
1995 Lown KS, Thummel KE, Benedict PE, Shen DD, Turgeon DK, Berent S, Watkins PB. The erythromycin breath test predicts the clearance of midazolam. Clinical Pharmacology and Therapeutics. 57: 16-24. PMID 7828377 DOI: 10.1016/0009-9236(95)90261-9  0.52
1994 Kerr BM, Thummel KE, Wurden CJ, Klein SM, Kroetz DL, Gonzalez FJ, Levy RH. Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. Biochemical Pharmacology. 47: 1969-79. PMID 8010982 DOI: 10.1016/0006-2952(94)90071-X  0.52
Show low-probability matches.