| Year |
Citation |
Score |
| 2024 |
Alade AN, Claw KG, McDonald MG, Prasad B, Rettie AE, Thummel KE. Cytochrome P450 Family and Haplotype Mapping and Association with Hepatic Gene Expression and Vitamin K Hydroxylation Activity. Acs Pharmacology & Translational Science. 7: 716-732. PMID 38481683 DOI: 10.1021/acsptsci.3c00287 |
0.308 |
|
| 2023 |
Bergagnini-Kolev MC, Hsu S, Aitken ML, Goss CH, Hoofnagle AN, Zelnick LR, Lum D, Best CM, Thummel KE, Kestenbaum BR, de Boer IH, Lin YS. Metabolism and pharmacokinetics of vitamin D in patients with cystic fibrosis. The Journal of Steroid Biochemistry and Molecular Biology. 232: 106332. PMID 37217104 DOI: 10.1016/j.jsbmb.2023.106332 |
0.6 |
|
| 2022 |
Best CM, Thummel KE, Hsu S, Lin Y, Zelnick LR, Kestenbaum B, Kushnir MM, de Boer IH, Hoofnagle AN. The plasma free fraction of 25-hydroxyvitamin D is not strongly associated with 25-hydroxyvitamin D clearance in kidney disease patients and controls. The Journal of Steroid Biochemistry and Molecular Biology. 226: 106206. PMID 36404469 DOI: 10.1016/j.jsbmb.2022.106206 |
0.611 |
|
| 2021 |
Hsu S, Zelnick LR, Lin YS, Best CM, Kestenbaum BR, Thummel KE, Hoofnagle AN, de Boer IH. Validation of the 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D ratio as a biomarker of 25-hydroxyvitamin D clearance. The Journal of Steroid Biochemistry and Molecular Biology. 106047. PMID 34954017 DOI: 10.1016/j.jsbmb.2021.106047 |
0.61 |
|
| 2021 |
Lin YS, Thummel KE, Thompson BD, Totah RA, Cho CW. Sources of Interindividual Variability. Methods in Molecular Biology (Clifton, N.J.). 2342: 481-550. PMID 34272705 DOI: 10.1007/978-1-0716-1554-6_17 |
0.637 |
|
| 2021 |
Henderson LM, Hopkins SE, Boyer BB, Thornton TA, Rettie AE, Thummel KE. Functional Effects of , a Novel and Common Variant in the Yup'ik Alaska Native Population. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 33632714 DOI: 10.1124/dmd.120.000301 |
0.309 |
|
| 2021 |
Fohner AE, Dalton R, Skagen K, Jackson K, Claw KG, Hopkins SE, Robinson R, Khan BA, Prasad B, Schuetz EG, Nickerson DA, Thornton TA, Dillard DA, Boyer BB, Thummel KE, et al. Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function. Clinical and Translational Science. PMID 33503331 DOI: 10.1111/cts.12970 |
0.322 |
|
| 2020 |
Hsu S, Zelnick LR, Lin YS, Best CM, Kestenbaum B, Thummel KE, Rose LM, Hoofnagle AN, de Boer IH. Differences in 25-Hydroxyvitamin D Clearance by eGFR and Race: A Pharmacokinetic Study. Journal of the American Society of Nephrology : Jasn. PMID 33115916 DOI: 10.1681/ASN.2020050625 |
0.608 |
|
| 2020 |
Tanna RS, Tian DD, Cech NB, Oberlies NH, Rettie AE, Thummel KE, Paine MF. Refined prediction of pharmacokinetic kratom-drug interactions: time-dependent inhibition considerations. The Journal of Pharmacology and Experimental Therapeutics. PMID 33093187 DOI: 10.1124/jpet.120.000270 |
0.319 |
|
| 2020 |
McDonald MG, Tian DD, Thummel KE, Paine MF, Rettie AE. Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 32591416 DOI: 10.1124/Dmd.120.091041 |
0.362 |
|
| 2020 |
Zhang H, Wolford C, Basit A, Li AP, Fan PW, Takahashi RH, Khojasteh SC, Smith BJ, Murray BP, Thummel K, Prasad B. Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 32350063 DOI: 10.1124/Dmd.120.090738 |
0.372 |
|
| 2020 |
Jolliffe DA, Stefanidis C, Wang Z, Kermani NZ, Dimitrov V, White JH, McDonough JE, Janssens W, Pfeffer P, Griffiths CJ, Bush A, Guo Y, Christenson S, Adcock IM, Chung KF, ... Thummel KE, et al. Vitamin D Metabolism is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. PMID 32186892 DOI: 10.1164/Rccm.201909-1867Oc |
0.306 |
|
| 2020 |
Basit A, Prasad B, Estergreen JK, Sabath DE, Alade N, Veenstra D, Rettie AE, Thummel K. A novel LC-MS/MS assay for quantification of des-carboxy prothrombin and characterization of warfarin induced changes. Clinical and Translational Science. PMID 32004415 DOI: 10.1111/Cts.12757 |
0.303 |
|
| 2019 |
Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Hong Wong L, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, ... ... Thummel KE, et al. Interrogation of CYP2D6 structural variant alleles improves the correlation between CYP2D6 genotype and CYP2D6-mediated metabolic activity. Clinical and Translational Science. PMID 31536170 DOI: 10.1111/Cts.12695 |
0.346 |
|
| 2019 |
Claw KG, Beans JA, Lee SB, Avey JP, Stapleton PA, Scherer SE, El-Boraie A, Tyndale RF, Nickerson DA, Dillard DA, Thummel KE, Robinson RF. Pharmacogenomics of nicotine metabolism: novel CYP2A6 and CYP2B6 genetic variation patterns in Alaska Native and American Indian populations. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31241144 DOI: 10.1093/Ntr/Ntz105 |
0.32 |
|
| 2019 |
Martineau AR, Thummel KE, Wang Z, Jolliffe DA, Boucher BJ, Griffin SJ, Forouhi NG, Hitman GA. Differential effects of oral boluses of vitamin D2 versus vitamin D3 on vitamin D metabolism: a randomized controlled trial. The Journal of Clinical Endocrinology and Metabolism. PMID 31199458 DOI: 10.1210/Jc.2019-00207 |
0.323 |
|
| 2019 |
Henderson LM, Robinson RF, Ray L, Li T, Dillard DA, Schilling BD, Mosley M, Janssen PL, Fohner AE, Rettie AE, Thummel KE, Thornton TA, Veenstra DL. VKORC1 and Novel CYP2C9 Variation Predict Warfarin Response in Alaska Native and American Indian People. Clinical and Translational Science. PMID 30821933 DOI: 10.1111/Cts.12611 |
0.316 |
|
| 2018 |
Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE. Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system. Altex. PMID 29999169 DOI: 10.14573/Altex.1803161 |
0.363 |
|
| 2018 |
Lee SB, Wheeler MM, Patterson K, McGee S, Dalton R, Woodahl EL, Gaedigk A, Thummel KE, Nickerson DA. Stargazer: a software tool for calling star alleles from next-generation sequencing data using CYP2D6 as a model. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 29875422 DOI: 10.1038/S41436-018-0054-0 |
0.352 |
|
| 2018 |
Gao C, Liao MZ, Han LW, Thummel KE, Mao Q. Hepatic transport of 25-hydroxyvitamin Dconjugates: a mechanism of 25-hydroxyvitamin Ddelivery to the intestinal tract. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29467214 DOI: 10.1124/Dmd.117.078881 |
0.417 |
|
| 2018 |
Roizen JD, Li D, O'Lear L, Javaid MK, Shaw NJ, Ebeling PR, Nguyen HH, Rodda CP, Thummel KE, Thacher TD, Hakonarson H, Levine MA. CYP3A4 mutation causes vitamin D-dependent rickets type 3. The Journal of Clinical Investigation. PMID 29461981 DOI: 10.1172/Jci98680 |
0.355 |
|
| 2018 |
Khan BA, Robinson R, Fohner AE, Muzquiz LI, Schilling BD, Beans JA, Olnes MJ, Trawicki L, Frydenlund H, Laukes C, Beatty P, Phillips B, Nickerson D, Howlett K, Dillard DA, ... ... Thummel KE, et al. Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People. Clinical and Translational Science. PMID 29436156 DOI: 10.1111/Cts.12542 |
0.401 |
|
| 2018 |
Wong T, Wang Z, Chapron BD, Suzuki M, Claw KG, Gao C, Foti RS, Prasad B, Chapron A, Calamia J, Chaudhry A, Schuetz EG, Horst RL, Mao Q, de Boer IH, ... ... Thummel KE, et al. Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-sulfate, A Major Circulating Vitamin D Metabolite in Humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29343609 DOI: 10.1124/Dmd.117.078428 |
0.427 |
|
| 2018 |
Tanner JA, Zhu AZ, Claw KG, Prasad B, Korchina V, Hu J, Doddapaneni H, Muzny DM, Schuetz EG, Lerman C, Thummel KE, Scherer SE, Tyndale RF. Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenetics and Genomics. 28: 7-16. PMID 29232328 DOI: 10.1097/Fpc.0000000000000317 |
0.378 |
|
| 2017 |
Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson D, Schuetz E, Rettie AE, Leeder S, Thummel KE, Prasad B. Genetic and Non-genetic Factors Associated with Protein Abundance of Flavin-containing Monooxygenase 3 in Human Liver. The Journal of Pharmacology and Experimental Therapeutics. PMID 28819071 DOI: 10.1124/Jpet.117.243113 |
0.358 |
|
| 2017 |
Gao C, Bergagnini-Kolev MC, Liao MZ, Wang Z, Wong T, Calamia JC, Lin YS, Mao Q, Thummel KE. Simultaneous quantification of 25-hydroxyvitamin D3-3-sulfate and 25-hydroxyvitamin D3-3-glucuronide in human serum and plasma using liquid chromatography-tandem mass spectrometry coupled with DAPTAD-derivatization. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1060: 158-165. PMID 28622619 DOI: 10.1016/J.Jchromb.2017.06.017 |
0.645 |
|
| 2017 |
Hawkes CP, Li D, Hakonarson H, Meyers KE, Thummel K, Levine MA. CYP3A4 induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients with CYP24A1 Mutations. The Journal of Clinical Endocrinology and Metabolism. PMID 28324001 DOI: 10.1210/Jc.2016-4048 |
0.398 |
|
| 2016 |
Tanner JA, Prasad B, Claw KG, Stapleton P, Chaudhry A, Schuetz EG, Thummel KE, Tyndale RF. Predictors of variation in CYP2A6 mRNA, protein, and enzyme activity in a human liver bank: influence of genetic and non-genetic factors. The Journal of Pharmacology and Experimental Therapeutics. PMID 27815364 DOI: 10.1124/Jpet.116.237594 |
0.408 |
|
| 2016 |
Aslibekyan S, Vaughan LK, Wiener HW, Hidalgo BA, Lemas DJ, O'Brien DM, Hopkins SE, Stanhope KL, Havel PJ, Thummel KE, Boyer BB, Tiwari HK. Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup'ik people. Genes & Nutrition. 11: 23. PMID 27579147 DOI: 10.1186/S12263-016-0538-Y |
0.326 |
|
| 2016 |
Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney International. 90: 627-37. PMID 27521113 DOI: 10.1016/J.Kint.2016.06.011 |
0.341 |
|
| 2015 |
Yamaura Y, Chapron BD, Wang Z, Himmelfarb J, Thummel KE. Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26700954 DOI: 10.1124/Dmd.115.068429 |
0.34 |
|
| 2015 |
Tracy TS, Chaudhry AS, Prasad B, Thummel KE, Schuetz EG, Zhong XB, Tien YC, Jeong H, Pan X, Shireman LM, Tay-Sontheimer J, Lin YS. Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26681736 DOI: 10.1124/Dmd.115.067900 |
0.665 |
|
| 2015 |
Fohner AE, Wang Z, Yracheta J, O'Brien DM, Hopkins SE, Black J, Philip J, Wiener HW, Tiwari HK, Stapleton PL, Tsai JM, Thornton TA, Boyer BB, Thummel KE. Genetics, Diet, and Season Are Associated with Serum 25-Hydroxycholecalciferol Concentration in a Yup'ik Study Population from Southwestern Alaska. The Journal of Nutrition. PMID 26661839 DOI: 10.3945/Jn.115.223388 |
0.314 |
|
| 2015 |
Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE. Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content. The Pharmacogenomics Journal. PMID 26323597 DOI: 10.1038/Tpj.2015.58 |
0.402 |
|
| 2015 |
Chaudhry AS, Prasad B, Shirasaka Y, Fohner A, Finkelstein D, Fan Y, Wang S, Wu G, Aklillu E, Sim SC, Thummel KE, Schuetz EG. The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1226-35. PMID 26021325 DOI: 10.1124/Dmd.115.064428 |
0.321 |
|
| 2015 |
Vyhlidal CA, Pearce RE, Gaedigk R, Calamia JC, Shuster DL, Thummel KE, Leeder JS. Variability in Expression of CYP3A5 in Human Fetal Liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 25979262 DOI: 10.1124/Dmd.115.064998 |
0.474 |
|
| 2015 |
Fohner AE, Robinson R, Yracheta J, Dillard DA, Schilling B, Khan B, Hopkins S, Boyer BB, Black J, Wiener H, Tiwari HK, Gordon A, Nickerson D, Tsai JM, Farin FM, ... ... Thummel KE, et al. Variation in genes controlling warfarin disposition and response in American Indian and Alaska Native people: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX. Pharmacogenetics and Genomics. 25: 343-53. PMID 25946405 DOI: 10.1097/Fpc.0000000000000143 |
0.344 |
|
| 2015 |
Chapron B, Risler L, Phillips B, Collins C, Thummel K, Shen D. Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, SociéTé Canadienne Des Sciences Pharmaceutiques. 18: 101-11. PMID 25877445 DOI: 10.18433/J3288C |
0.433 |
|
| 2015 |
Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, Wang D, Vinks AA, He Y, Swen JJ, Leeder JS, van Schaik R, Thummel KE, Klein TE, Caudle KE, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Clinical Pharmacology and Therapeutics. 98: 19-24. PMID 25801146 DOI: 10.1002/Cpt.113 |
0.388 |
|
| 2015 |
Burke W, Thummel K. A call for accurate pharmacogenetic labeling: telling it like it is. Jama Internal Medicine. 174: 1945-6. PMID 25317574 DOI: 10.1001/Jamainternmed.2014.3276 |
0.332 |
|
| 2014 |
Tay-Sontheimer J, Shireman LM, Beyer RP, Senn T, Witten D, Pearce RE, Gaedigk A, Gana Fomban CL, Lutz JD, Isoherranen N, Thummel KE, Fiehn O, Leeder JS, Lin YS. Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics. Pharmacogenomics. 15: 1947-62. PMID 25521354 DOI: 10.2217/Pgs.14.155 |
0.617 |
|
| 2014 |
Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochemical Pharmacology. 92: 690-700. PMID 25450675 DOI: 10.1016/J.Bcp.2014.09.025 |
0.436 |
|
| 2014 |
Canestaro WJ, Austin MA, Thummel KE. Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 16: 810-9. PMID 24810685 DOI: 10.1038/Gim.2014.41 |
0.322 |
|
| 2014 |
de Boer IH, Sachs MC, Chonchol M, Himmelfarb J, Hoofnagle AN, Ix JH, Kremsdorf RA, Lin YS, Mehrotra R, Robinson-Cohen C, Siscovick DS, Steffes MW, Thummel KE, Tracy RP, Wang Z, et al. Estimated GFR and circulating 24,25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 64: 187-97. PMID 24703961 DOI: 10.1053/J.Ajkd.2014.02.015 |
0.629 |
|
| 2014 |
Wang Z, Wong T, Hashizume T, Dickmann LZ, Scian M, Koszewski NJ, Goff JP, Horst RL, Chaudhry AS, Schuetz EG, Thummel KE. Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability. Endocrinology. 155: 2052-63. PMID 24641623 DOI: 10.1210/En.2013-2013 |
0.426 |
|
| 2014 |
Thummel KE, Lin YS. Sources of interindividual variability. Methods in Molecular Biology (Clifton, N.J.). 1113: 363-415. PMID 24523121 DOI: 10.1007/978-1-62703-758-7_17 |
0.675 |
|
| 2014 |
Barr JT, Choughule KV, Nepal S, Wong T, Chaudhry AS, Joswig-Jones CA, Zientek M, Strom SC, Schuetz EG, Thummel KE, Jones JP. Why do most human liver cytosol preparations lack xanthine oxidase activity? Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 695-9. PMID 24430612 DOI: 10.1124/Dmd.113.056374 |
0.378 |
|
| 2014 |
Yeung CK, Shen DD, Thummel KE, Himmelfarb J. Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. Kidney International. 85: 522-8. PMID 24132209 DOI: 10.1038/Ki.2013.399 |
0.397 |
|
| 2013 |
Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, et al. Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. Stem Cell Research & Therapy. 4: S17. PMID 24564863 DOI: 10.1186/Scrt378 |
0.345 |
|
| 2013 |
Fohner A, Muzquiz LI, Austin MA, Gaedigk A, Gordon A, Thornton T, Rieder MJ, Pershouse MA, Putnam EA, Howlett K, Beatty P, Thummel KE, Woodahl EL. Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes. Pharmacogenetics and Genomics. 23: 403-14. PMID 23778323 DOI: 10.1097/Fpc.0B013E3283629Ce9 |
0.37 |
|
| 2013 |
Shirasaka Y, Chang SY, Grubb MF, Peng CC, Thummel KE, Isoherranen N, Rodrigues AD. Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1566-74. PMID 23723360 DOI: 10.1124/Dmd.112.049940 |
0.421 |
|
| 2013 |
Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD, Thummel KE. CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition. Transplantation. 95: 821-7. PMID 23354298 DOI: 10.1097/Tp.0B013E31827E6Ad9 |
0.656 |
|
| 2013 |
Isoherranen N, Thummel KE. Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes? Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 256-62. PMID 23328895 DOI: 10.1124/Dmd.112.050245 |
0.376 |
|
| 2013 |
Wang Z, Lin YS, Dickmann LJ, Poulton EJ, Eaton DL, Lampe JW, Shen DD, Davis CL, Shuhart MC, Thummel KE. Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: implications for drug-induced osteomalacia. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 1101-16. PMID 23212742 DOI: 10.1002/Jbmr.1839 |
0.702 |
|
| 2013 |
Shuster DL, Bammler TK, Beyer RP, Macdonald JW, Tsai JM, Farin FM, Hebert MF, Thummel KE, Mao Q. Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 332-42. PMID 23175668 DOI: 10.1124/Dmd.112.049718 |
0.403 |
|
| 2013 |
Poulton EJ, Levy L, Lampe JW, Shen DD, Tracy J, Shuhart MC, Thummel KE, Eaton DL. Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo. Toxicology and Applied Pharmacology. 266: 122-31. PMID 23153560 DOI: 10.1016/J.Taap.2012.10.029 |
0.352 |
|
| 2013 |
Baker PE, Cole TB, Cartwright M, Suzuki SM, Thummel KE, Lin YS, Co AL, Rettie AE, Kim JH, Furlong CE. Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants. Chemico-Biological Interactions. 203: 257-64. PMID 23085349 DOI: 10.1016/J.Cbi.2012.10.005 |
0.65 |
|
| 2013 |
Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. The Journal of Steroid Biochemistry and Molecular Biology. 136: 54-8. PMID 22985909 DOI: 10.1016/J.Jsbmb.2012.09.012 |
0.402 |
|
| 2013 |
Witt K, Jolliffe D, Wang Z, Thummel K, Timms P, Griffiths C, Martineau A. P90 Vitamin D status improves following recovery from tuberculosis Thorax. 68. DOI: 10.1136/Thoraxjnl-2013-204457.240 |
0.331 |
|
| 2012 |
Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD, Thummel KE. Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition. Clinical Pharmacology and Therapeutics. 92: 737-45. PMID 23073208 DOI: 10.1038/Clpt.2012.175 |
0.694 |
|
| 2012 |
Laha TJ, Strathmann FG, Wang Z, de Boer IH, Thummel KE, Hoofnagle AN. Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry. Clinical Chemistry. 58: 1711-6. PMID 22968104 DOI: 10.1373/Clinchem.2012.185827 |
0.32 |
|
| 2012 |
Zheng XE, Wang Z, Liao MZ, Lin YS, Shuhart MC, Schuetz EG, Thummel KE. Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells. Biochemical Pharmacology. 84: 391-401. PMID 22562045 DOI: 10.1016/J.Bcp.2012.04.019 |
0.669 |
|
| 2012 |
Thirumaran RK, Lamba JK, Kim RB, Urquhart BL, Gregor JC, Chande N, Fan Y, Qi A, Cheng C, Thummel KE, Hall SD, Schuetz EG. Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation. Biochemical Pharmacology. 84: 104-12. PMID 22484315 DOI: 10.1016/J.Bcp.2012.03.017 |
0.429 |
|
| 2012 |
Wang Z, Lin YS, Zheng XE, Senn T, Hashizume T, Scian M, Dickmann LJ, Nelson SD, Baillie TA, Hebert MF, Blough D, Davis CL, Thummel KE. An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway. Molecular Pharmacology. 81: 498-509. PMID 22205755 DOI: 10.1124/Mol.111.076356 |
0.689 |
|
| 2012 |
Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 610-6. PMID 22190694 DOI: 10.1124/Dmd.111.042705 |
0.361 |
|
| 2012 |
Thirumaran RK, Lamba JK, Kim RB, Urquhart BL, Gregor JC, Chande N, Fan Y, Thummel KE, Hall SD, Schuetz EG. Intestinal CYP3A4 and midazolam disposition in vivo show seasonal variation and associate with VDR polymorphisms F1000research. 3. DOI: 10.7490/F1000Research.1089481.1 |
0.443 |
|
| 2011 |
Yang J, Atkins WM, Isoherranen N, Paine MF, Thummel KE. Evidence of CYP3A allosterism in vivo: analysis of interaction between fluconazole and midazolam. Clinical Pharmacology and Therapeutics. 91: 442-9. PMID 22048224 DOI: 10.1038/Clpt.2011.178 |
0.409 |
|
| 2011 |
Kirby BJ, Collier AC, Kharasch ED, Dixit V, Desai P, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2329-37. PMID 21930825 DOI: 10.1124/Dmd.111.038646 |
0.433 |
|
| 2011 |
Wang Z, Senn T, Kalhorn T, Zheng XE, Zheng S, Davis CL, Hebert MF, Lin YS, Thummel KE. Simultaneous measurement of plasma vitamin D(3) metabolites, including 4β,25-dihydroxyvitamin D(3), using liquid chromatography-tandem mass spectrometry. Analytical Biochemistry. 418: 126-33. PMID 21784054 DOI: 10.1016/J.Ab.2011.06.043 |
0.636 |
|
| 2011 |
Innocenti F, Cooper GM, Stanaway IB, Gamazon ER, Smith JD, Mirkov S, Ramirez J, Liu W, Lin YS, Moloney C, Aldred SF, Trinklein ND, Schuetz E, Nickerson DA, Thummel KE, et al. Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. Plos Genetics. 7: e1002078. PMID 21637794 DOI: 10.1371/Journal.Pgen.1002078 |
0.624 |
|
| 2011 |
Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1070-8. PMID 21406602 DOI: 10.1124/Dmd.110.037523 |
0.432 |
|
| 2010 |
Templeton I, Peng CC, Thummel KE, Davis C, Kunze KL, Isoherranen N. Accurate prediction of dose-dependent CYP3A4 inhibition by itraconazole and its metabolites from in vitro inhibition data. Clinical Pharmacology and Therapeutics. 88: 499-505. PMID 20739919 DOI: 10.1038/Clpt.2010.119 |
0.405 |
|
| 2010 |
Suresh BN, Lin YS, Rieder MJ, Marciante KD, Psaty BM, Thummel KE, Totah RA. Human liver expression of CYP2C8: Gender, age, and genotype effects Drug Metabolism and Disposition. 38: 889-893. PMID 20190184 DOI: 10.1124/Dmd.109.031542 |
0.696 |
|
| 2009 |
Zhao P, Ragueneau-Majlessi I, Zhang L, Strong JM, Reynolds KS, Levy RH, Thummel KE, Huang SM. Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole: a simulation study. Journal of Clinical Pharmacology. 49: 351-9. PMID 19246732 DOI: 10.1177/0091270008331196 |
0.342 |
|
| 2009 |
McConn DJ, Lin YS, Mathisen TL, Blough DK, Xu Y, Hashizume T, Taylor SL, Thummel KE, Shuhart MC. Reduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis. Clinical Pharmacology and Therapeutics. 85: 387-93. PMID 19212316 DOI: 10.1038/Clpt.2008.292 |
0.796 |
|
| 2008 |
Smith HE, Jones JP, Kalhorn TF, Farin FM, Stapleton PL, Davis CL, Perkins JD, Blough DK, Hebert MF, Thummel KE, Totah RA. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. Pharmacogenetics and Genomics. 18: 943-53. PMID 18769365 DOI: 10.1097/Fpc.0B013E32830E1E16 |
0.391 |
|
| 2008 |
Huang SM, Strong JM, Zhang L, Reynolds KS, Nallani S, Temple R, Abraham S, Habet SA, Baweja RK, Burckart GJ, Chung S, Colangelo P, Frucht D, Green MD, Hepp P, ... ... Thummel K, et al. New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process. Journal of Clinical Pharmacology. 48: 662-70. PMID 18378963 DOI: 10.1177/0091270007312153 |
0.305 |
|
| 2008 |
Gupta A, Mugundu GM, Desai PB, Thummel KE, Unadkat JD. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1172-80. PMID 18332086 DOI: 10.1124/Dmd.107.018689 |
0.386 |
|
| 2008 |
Totah RA, Sheffels P, Roberts T, Whittington D, Thummel K, Kharasch ED. Role of CYP2B6 in stereoselective human methadone metabolism. Anesthesiology. 108: 363-74. PMID 18292673 DOI: 10.1097/Aln.0B013E3181642938 |
0.428 |
|
| 2008 |
Hebert MF, Easterling TR, Kirby B, Carr DB, Buchanan ML, Rutherford T, Thummel KE, Fishbein DP, Unadkat JD. Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study. Clinical Pharmacology and Therapeutics. 84: 248-53. PMID 18288078 DOI: 10.1038/Clpt.2008.1 |
0.328 |
|
| 2008 |
Poonkuzhali B, Lamba J, Strom S, Sparreboom A, Thummel K, Watkins P, Schuetz E. Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 780-95. PMID 18180275 DOI: 10.1124/Dmd.107.018366 |
0.362 |
|
| 2008 |
Hashizume T, Xu Y, Mohutsky MA, Alberts J, Hadden C, Kalhorn TF, Isoherranen N, Shuhart MC, Thummel KE. Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation. Biochemical Pharmacology. 75: 1240-50. PMID 18177842 DOI: 10.1016/J.Bcp.2007.11.008 |
0.42 |
|
| 2008 |
Isoherranen N, Ludington SR, Givens RC, Lamba JK, Pusek SN, Dees EC, Blough DK, Iwanaga K, Hawke RL, Schuetz EG, Watkins PB, Thummel KE, Paine MF. The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 146-54. PMID 17954524 DOI: 10.1124/Dmd.107.018382 |
0.435 |
|
| 2008 |
Templeton IE, Thummel KE, Kharasch ED, Kunze KL, Hoffer C, Nelson WL, Isoherranen N. Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. Clinical Pharmacology and Therapeutics. 83: 77-85. PMID 17495874 DOI: 10.1038/Sj.Clpt.6100230 |
0.454 |
|
| 2007 |
Thummel KE. Gut instincts: CYP3A4 and intestinal drug metabolism. The Journal of Clinical Investigation. 117: 3173-6. PMID 17975661 DOI: 10.1172/Jci34007 |
0.428 |
|
| 2007 |
Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD. Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1853-9. PMID 17639026 DOI: 10.1124/Dmd.107.016089 |
0.406 |
|
| 2007 |
Huang W, Kalhorn TF, Baillie M, Shen DD, Thummel KE. Determination of free and total cortisol in plasma and urine by liquid chromatography-tandem mass spectrometry. Therapeutic Drug Monitoring. 29: 215-24. PMID 17417077 DOI: 10.1097/Ftd.0B013E31803D14C0 |
0.659 |
|
| 2007 |
Zhou C, Poulton EJ, Grün F, Bammler TK, Blumberg B, Thummel KE, Eaton DL. The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Molecular Pharmacology. 71: 220-9. PMID 17028159 DOI: 10.1124/Mol.106.029264 |
0.439 |
|
| 2006 |
Zhou C, Tabb MM, Nelson EL, Grün F, Verma S, Sadatrafiei A, Lin M, Mallick S, Forman BM, Thummel KE, Blumberg B. Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. The Journal of Clinical Investigation. 116: 2280-2289. PMID 16841097 DOI: 10.1172/Jci26283 |
0.334 |
|
| 2006 |
Xu Y, Iwanaga K, Zhou C, Cheesman MJ, Farin F, Thummel KE. Selective induction of intestinal CYP3A23 by 1alpha,25-dihydroxyvitamin D3 in rats. Biochemical Pharmacology. 72: 385-92. PMID 16769037 DOI: 10.1016/J.Bcp.2006.04.033 |
0.437 |
|
| 2006 |
Zhou C, Assem M, Tay JC, Watkins PB, Blumberg B, Schuetz EG, Thummel KE. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. The Journal of Clinical Investigation. 116: 1703-12. PMID 16691293 DOI: 10.1172/Jci27793 |
0.416 |
|
| 2006 |
Lamba J, Strom S, Venkataramanan R, Thummel KE, Lin YS, Liu W, Cheng C, Lamba V, Watkins PB, Schuetz E. MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype. Clinical Pharmacology and Therapeutics. 79: 325-38. PMID 16580901 DOI: 10.1016/J.Clpt.2005.11.013 |
0.657 |
|
| 2006 |
Dai Y, Hebert MF, Isoherranen N, Davis CL, Marsh C, Shen DD, Thummel KE. Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 836-47. PMID 16501005 DOI: 10.1124/Dmd.105.008680 |
0.477 |
|
| 2006 |
Kunze KL, Nelson WL, Kharasch ED, Thummel KE, Isoherranen N. Stereochemical aspects of itraconazole metabolism in vitro and in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 583-90. PMID 16415110 DOI: 10.1124/Dmd.105.008508 |
0.342 |
|
| 2006 |
Gupta A, Dai Y, Vethanayagam RR, Hebert MF, Thummel KE, Unadkat JD, Ross DD, Mao Q. Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemotherapy and Pharmacology. 58: 374-83. PMID 16404634 DOI: 10.1007/S00280-005-0173-6 |
0.33 |
|
| 2006 |
Xu Y, Hashizume T, Shuhart MC, Davis CL, Nelson WL, Sakaki T, Kalhorn TF, Watkins PB, Schuetz EG, Thummel KE. Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Molecular Pharmacology. 69: 56-65. PMID 16207822 DOI: 10.1124/Mol.105.017392 |
0.483 |
|
| 2005 |
Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM, Ratain MJ, Thummel K. Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests. Clinical Pharmacology and Therapeutics. 78: 559-81. PMID 16338273 DOI: 10.1016/J.Clpt.2005.08.013 |
0.373 |
|
| 2005 |
Kharasch ED, Thummel KE, Watkins PB. CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition. Molecular Interventions. 5: 151-3. PMID 15994453 DOI: 10.1124/Mi.5.3.3 |
0.43 |
|
| 2005 |
Rieder MJ, Reiner AP, Gage BF, Nickerson DA, Eby CS, McLeod HL, Blough DK, Thummel KE, Veenstra DL, Rettie AE. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. The New England Journal of Medicine. 352: 2285-93. PMID 15930419 DOI: 10.1056/Nejmoa044503 |
0.311 |
|
| 2005 |
McCune JS, Risler LJ, Phillips BR, Thummel KE, Blough D, Shen DD. Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1074-81. PMID 15821045 DOI: 10.1124/Dmd.104.002279 |
0.424 |
|
| 2005 |
Klees TM, Sheffels P, Thummel KE, Kharasch ED. Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5. Anesthesiology. 102: 550-6. PMID 15731592 DOI: 10.1097/00000542-200503000-00012 |
0.473 |
|
| 2004 |
Dai Y, Iwanaga K, Lin YS, Hebert MF, Davis CL, Huang W, Kharasch ED, Thummel KE. In vitro metabolism of cyclosporine A by human kidney CYP3A5 Biochemical Pharmacology. 68: 1889-1902. PMID 15450954 DOI: 10.1016/J.Bcp.2004.07.012 |
0.806 |
|
| 2004 |
Huang W, Lin YS, McConn DJ, Calamia JC, Totah RA, Isoherranen N, Glodowski M, Thummel KE. Evidence of significant contribution from CYP3A5 to hepatic drug metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1434-45. PMID 15383492 DOI: 10.1124/Dmd.104.001313 |
0.783 |
|
| 2004 |
McConn DJ, Lin YS, Allen K, Kunze KL, Thummel KE. Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1083-91. PMID 15377640 DOI: 10.1124/Dmd.32.10.1083 |
0.791 |
|
| 2004 |
Isoherranen N, Kunze KL, Allen KE, Nelson WL, Thummel KE. Role of itraconazole metabolites in CYP3A4 inhibition. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1121-31. PMID 15242978 DOI: 10.1124/Dmd.104.000315 |
0.4 |
|
| 2004 |
McConnachie L, Bodor M, Kowdley K, Levy A, Tung B, Thummel K, Phillips B, Bajpai M, Chi V, Esmay JD, Shen DD, Ho RJ. Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate. Clinical Pharmacology and Therapeutics. 75: 282-97. PMID 15060507 DOI: 10.1016/J.Clpt.2003.12.003 |
0.433 |
|
| 2003 |
Hebert MF, Dowling AL, Gierwatowski C, Lin YS, Edwards KL, Davis CL, Marsh CL, Schuetz EG, Thummel KE. Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors. Pharmacogenetics. 13: 661-74. PMID 14583679 DOI: 10.1097/00008571-200311000-00002 |
0.633 |
|
| 2003 |
Thummel KE. Does the CYP3A5*3 polymorphism affect in vivo drug elimination? Pharmacogenetics. 13: 585-7. PMID 14515056 DOI: 10.1097/00008571-200310000-00001 |
0.374 |
|
| 2003 |
Park JM, Lin YS, Calamia JC, Thummel KE, Slattery JT, Kalhorn TF, Carithers RL, Levy AE, Marsh CL, Hebert MF. Transiently altered acetaminophen metabolism after liver transplantation. Clinical Pharmacology and Therapeutics. 73: 545-53. PMID 12811364 DOI: 10.1016/S0009-9236(03)00062-6 |
0.669 |
|
| 2003 |
Spracklin DK, Emery ME, Thummel KE, Kharasch ED. Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. Acta Anaesthesiologica Scandinavica. 47: 765-70. PMID 12803597 DOI: 10.1034/J.1399-6576.2003.00126.X |
0.33 |
|
| 2003 |
Givens RC, Lin YS, Dowling AL, Thummel KE, Lamba JK, Schuetz EG, Stewart PW, Watkins PB. CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 1297-300. PMID 12754175 DOI: 10.1152/Japplphysiol.00322.2003 |
0.661 |
|
| 2003 |
Carcillo JA, Adedoyin A, Burckart GJ, Frye RF, Venkataramanan R, Knoll C, Thummel K, Roskos L, Wilson JW, Sereika S, Romkes M, Bebia Z, Branch RA. Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation. Clinical Pharmacology and Therapeutics. 73: 456-67. PMID 12732845 DOI: 10.1016/S0009-9236(03)00055-9 |
0.425 |
|
| 2003 |
Rettie AE, Tai G, Veenstra DL, Farin FM, Srinouanprachan S, Lin YS, Thummel KE, Hines RN. CYP2C9 exon 4 mutations and warfarin dose phenotype in Asians. Blood. 101: 2896-7. PMID 12642346 DOI: 10.1182/Blood-2002-11-3452 |
0.595 |
|
| 2003 |
Zamber CP, Lamba JK, Yasuda K, Farnum J, Thummel K, Schuetz JD, Schuetz EG. Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. Pharmacogenetics. 13: 19-28. PMID 12544509 DOI: 10.1097/00008571-200301000-00004 |
0.339 |
|
| 2003 |
Nelson SD, Slattery JT, Thummel KE, Watkins PB. Car unlikely to significantly modulate acetaminophen hepatotoxicity in most humans Hepatology. 38: 254-257. DOI: 10.1002/Hep.510380133 |
0.336 |
|
| 2002 |
Lamba JK, Lin YS, Schuetz EG, Thummel KE. Genetic contribution to variable human CYP3A-mediated metabolism. Advanced Drug Delivery Reviews. 54: 1271-94. PMID 12406645 DOI: 10.1016/S0169-409X(02)00066-2 |
0.711 |
|
| 2002 |
Lin YS, Dowling AL, Quigley SD, Farin FM, Zhang J, Lamba J, Schuetz EG, Thummel KE. Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism. Molecular Pharmacology. 62: 162-72. PMID 12065767 DOI: 10.1124/Mol.62.1.162 |
0.694 |
|
| 2002 |
Paine MF, Leung LY, Lim HK, Liao K, Oganesian A, Zhang MY, Thummel KE, Watkins PB. Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion. The Journal of Pharmacology and Experimental Therapeutics. 301: 174-86. PMID 11907172 DOI: 10.1124/Jpet.301.1.174 |
0.387 |
|
| 2002 |
Lamba JK, Lin YS, Thummel K, Daly A, Watkins PB, Strom S, Zhang J, Schuetz EG. Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics. 12: 121-32. PMID 11875366 DOI: 10.1097/00008571-200203000-00006 |
0.685 |
|
| 2001 |
Lin YS, Lockwood GF, Graham MA, Brian WR, Loi CM, Dobrinska MR, Shen DD, Watkins PB, Wilkinson GR, Kharasch ED, Thummel KE. In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration. Pharmacogenetics. 11: 781-91. PMID 11740342 DOI: 10.1097/00008571-200112000-00006 |
0.651 |
|
| 2001 |
Thummel KE, Brimer C, Yasuda K, Thottassery J, Senn T, Lin Y, Ishizuka H, Kharasch E, Schuetz J, Schuetz E. Transcriptional control of intestinal cytochrome P-4503A by 1α,25-dihydroxy vitamin D3 Molecular Pharmacology. 60: 1399-1406. PMID 11723248 DOI: 10.1124/Mol.60.6.1399 |
0.662 |
|
| 2001 |
Zhang J, Kuehl P, Green ED, Touchman JW, Watkins PB, Daly A, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Wrighton SA, Hancock M, Kim RB, Strom S, ... Thummel K, et al. The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics. 11: 555-72. PMID 11668216 DOI: 10.1097/00008571-200110000-00003 |
0.382 |
|
| 2001 |
Tateishi T, Watanabe M, Nakura H, Asoh M, Shirai H, Mizorogi Y, Kobayashi S, Thummel KE, Wilkinson GR. CYP3A activity in European American and Japanese men using midazolam as an in vivo probe. Clinical Pharmacology and Therapeutics. 69: 333-9. PMID 11372001 DOI: 10.1067/Mcp.2001.115447 |
0.301 |
|
| 2001 |
Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Venkataramanan R, ... ... Thummel K, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nature Genetics. 27: 383-91. PMID 11279519 DOI: 10.1038/86882 |
0.709 |
|
| 2000 |
Fisher MB, VandenBranden M, Findlay K, Burchell B, Thummel KE, Hall SD, Wrighton SA. Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: Relationship between UGT1A1 promoter genotype and variability in a liver bank Pharmacogenetics. 10: 727-739. PMID 11186135 DOI: 10.1097/00008571-200011000-00007 |
0.307 |
|
| 2000 |
Paine MF, Davis CL, Shen DD, Marsh CL, Raisys VA, Thummel KE. Can oral midazolam predict oral cyclosporine disposition? European Journal of Pharmaceutical Sciences. 12: 51-62. PMID 11121733 DOI: 10.1016/S0928-0987(00)00139-1 |
0.424 |
|
| 2000 |
Gibbs MA, Baillie MT, Shen DD, Kunze KL, Thummel KE. Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells. Pharmaceutical Research. 17: 299-305. PMID 10801218 DOI: 10.1023/A:1007550717526 |
0.367 |
|
| 1999 |
Kinirons MT, O'Shea D, Kim RB, Groopman JD, Thummel KE, Wood AJJ, Wilkinson GR. Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A Clinical Pharmacology and Therapeutics. 66: 224-231. PMID 10511057 DOI: 10.1016/S0009-9236(99)70029-9 |
0.422 |
|
| 1999 |
Hu M, Li Y, Davitt CM, Huang SM, Thummel K, Penman BW, Crespi CL. Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase. Pharmaceutical Research. 16: 1352-1359. PMID 10496649 DOI: 10.1023/A:1018986605929 |
0.339 |
|
| 1999 |
Madani S, Paine MF, Lewis L, Thummel KE, Shen DD. Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines Pharmaceutical Research. 16: 1199-1205. PMID 10468020 DOI: 10.1023/A:1018989211864 |
0.421 |
|
| 1999 |
Kharasch ED, Jubert C, Senn T, Bowdle TA, Thummel KE. Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance. Journal of Clinical Pharmacology. 39: 664-9. PMID 10392320 DOI: 10.1177/00912709922008290 |
0.449 |
|
| 1998 |
Kharasch ED, Hankins DC, Baxter PJ, Thummel KE. Single-dose disulfiram does not inhibit CYP2A6 activity. Clinical Pharmacology and Therapeutics. 64: 39-45. PMID 9695717 DOI: 10.1016/S0009-9236(98)90020-0 |
0.413 |
|
| 1997 |
Tran A, Rey E, Pons G, Rousseau M, d'Athis P, Olive G, Mather GG, Bishop FE, Wurden CJ, Labroo R, Trager WF, Kunze KL, Thummel KE, Vincent JC, Gillardin JM, et al. Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivo inhibition constants. Clinical Pharmacology and Therapeutics. 62: 490-504. PMID 9390105 DOI: 10.1016/S0009-9236(97)90044-8 |
0.356 |
|
| 1997 |
Kharasch ED, Russell M, Mautz D, Thummel KE, Kunze KL, Bowdle A, Cox K. The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions. Anesthesiology. 87: 36-50. PMID 9232132 DOI: 10.1097/00000542-199707000-00006 |
0.418 |
|
| 1997 |
Schmiedlin-Ren P, Thummel KE, Fisher JM, Paine MF, Lown KS, Watkins PB. Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3. Molecular Pharmacology. 51: 741-54. PMID 9145912 DOI: 10.1124/Mol.51.5.741 |
0.443 |
|
| 1997 |
Chien JY, Peter RM, Nolan CM, Wartell C, Slattery JT, Nelson SD, Carithers RL, Thummel KE. Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid. Clinical Pharmacology and Therapeutics. 61: 24-34. PMID 9024171 DOI: 10.1016/S0009-9236(97)90179-X |
0.318 |
|
| 1997 |
Janardan SK, Lown KS, Schmiedlin-Ren P, Thummel KE, Watkins PB. Selective expression of CYP3A5 and not CYP3A4 in human blood. Pharmacogenetics. 6: 379-85. PMID 8946469 DOI: 10.1097/00008571-199610000-00001 |
0.394 |
|
| 1997 |
Thummel KE, Kunze KL, Shen DD. Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction Advanced Drug Delivery Reviews. 27: 99-127. DOI: 10.1016/S0169-409X(97)00039-2 |
0.444 |
|
| 1997 |
Thummel KE. First-pass drug metabolism and its impact on oral drug delivery Advanced Drug Delivery Reviews. 27: 97-98. DOI: 10.1016/S0169-409X(97)00038-0 |
0.35 |
|
| 1996 |
Chen W, Peter RM, McArdle S, Thummel KE, Sigle RO, Nelson SD. Baculovirus expression and purification of human and rat cytochrome P450 2E1. Archives of Biochemistry and Biophysics. 335: 123-30. PMID 8914842 DOI: 10.1006/Abbi.1996.0489 |
0.324 |
|
| 1996 |
Paine MF, Shen DD, Kunze KL, Perkins JD, Marsh CL, McVicar JP, Barr DM, Gillies BS, Thummel KE. First-pass metabolism of midazolam by the human intestine Clinical Pharmacology and Therapeutics. 60: 14-24. PMID 8689807 DOI: 10.1016/S0009-9236(96)90162-9 |
0.404 |
|
| 1996 |
Mitra AK, Thummel KE, Kalhorn TF, Kharasch ED, Unadkat JD, Slattery JT. Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers. Clinical Pharmacology and Therapeutics. 59: 332-40. PMID 8653996 DOI: 10.1016/S0009-9236(96)80011-7 |
0.381 |
|
| 1996 |
Thummel KE, O'Shea D, Paine MF, Shen DD, Kunze KL, Perkins JD, Wilkinson GR. Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism Clinical Pharmacology and Therapeutics. 59: 491-502. PMID 8646820 DOI: 10.1016/S0009-9236(96)90177-0 |
0.411 |
|
| 1996 |
Kharasch ED, Hankins D, Mautz D, Thummel KE. Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. Lancet (London, England). 347: 1367-71. PMID 8637342 DOI: 10.1016/S0140-6736(96)91011-9 |
0.386 |
|
| 1995 |
Kharasch ED, Hankins DC, Thummel KE. Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology. 82: 689-99. PMID 7879937 DOI: 10.1097/00132586-199606000-00018 |
0.393 |
|
| 1995 |
Lown KS, Thummel KE, Benedict PE, Shen DD, Turgeon DK, Berent S, Watkins PB. The erythromycin breath test predicts the clearance of midazolam. Clinical Pharmacology and Therapeutics. 57: 16-24. PMID 7828377 DOI: 10.1016/0009-9236(95)90261-9 |
0.301 |
|
| 1995 |
Yin H, Anders MW, Korzekwa KR, Higgins L, Thummel KE, Kharasch ED, Jones JP. Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes. Proceedings of the National Academy of Sciences of the United States of America. 92: 11076-80. PMID 7479940 DOI: 10.1073/Pnas.92.24.11076 |
0.338 |
|
| 1994 |
Kharasch ED, Thummel KE, Mautz D, Bosse S. Clinical enflurane metabolism by cytochrome P450 2E1. Clinical Pharmacology and Therapeutics. 55: 434-40. PMID 8162670 DOI: 10.1038/Clpt.1994.53 |
0.38 |
|
| 1994 |
Myers TG, Thummel KE, Kalhorn TF, Nelson SD. Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. Journal of Medicinal Chemistry. 37: 860-7. PMID 8145237 DOI: 10.1021/Jm00032A021 |
0.332 |
|
| 1994 |
Kerr BM, Thummel KE, Wurden CJ, Klein SM, Kroetz DL, Gonzalez FJ, Levy RH. Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. Biochemical Pharmacology. 47: 1969-79. PMID 8010982 DOI: 10.1016/0006-2952(94)90071-X |
0.492 |
|
| 1994 |
KHARASCH ED, THUMMEL KE, MAUTZ D, BOSSE S. Clinical Enflurane Metabolism by Cytochrome P-450 2EI Survey of Anesthesiology. 38: 315. DOI: 10.1097/00132586-199412000-00008 |
0.341 |
|
| 1993 |
Kharasch ED, Thummel KE, Mhyre J, Lillibridge JH. Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1. Clinical Pharmacology and Therapeutics. 53: 643-50. PMID 8513656 DOI: 10.1038/Clpt.1993.85 |
0.364 |
|
| 1993 |
Kharasch ED, Thummel KE. Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance? Anesthesia and Analgesia. 76: 1033-9. PMID 8484504 DOI: 10.1213/00000539-199305000-00022 |
0.402 |
|
| 1993 |
Sadeque AJ, Thummel KE, Rettie AE. Purification of macaque liver flavin-containing monooxygenase: a form of the enzyme related immunochemically to an isozyme expressed selectively in adult human liver. Biochimica Et Biophysica Acta. 1162: 127-34. PMID 8448176 DOI: 10.1016/0167-4838(93)90138-H |
0.368 |
|
| 1993 |
Thummel KE, Lee CA, Kunze KL, Nelson SD, Slattery JT. Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4. Biochemical Pharmacology. 45: 1563-9. PMID 8387297 DOI: 10.1016/0006-2952(93)90295-8 |
0.468 |
|
| 1993 |
Zand R, Nelson SD, Slattery JT, Thummel KE, Kalhorn TF, Adams SP, Wright JM. Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans. Clinical Pharmacology and Therapeutics. 54: 142-9. PMID 8354023 DOI: 10.1038/Clpt.1993.125 |
0.329 |
|
| 1993 |
Kharasch ED, Thummel KE. Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology. 79: 795-807. PMID 8214760 DOI: 10.1097/00000542-199310000-00023 |
0.433 |
|
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