Jeffery L. Wrana - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Cell Biology, Molecular Biology

173 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Labibi B, Bashkurov M, Wrana JL, Attisano L. Modeling the Control of TGF-β/Smad Nuclear Accumulation by the Hippo Pathway Effectors, Taz/Yap. Iscience. 23: 101416. PMID 32798968 DOI: 10.1016/j.isci.2020.101416  0.4
2020 Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, ... ... Wrana J, et al. Functional characterization of a PROTAC directed against BRAF mutant V600E. Nature Chemical Biology. PMID 32778845 DOI: 10.1038/s41589-020-0609-7  0.48
2020 Aubry A, Pearson JD, Huang K, Livne-Bar I, Ahmad M, Jagadeesan M, Khetan V, Ketela T, Brown KR, Yu T, Lu S, Wrana JL, Moffat J, Bremner R. Functional genomics identifies new synergistic therapies for retinoblastoma. Oncogene. PMID 32572160 DOI: 10.1038/s41388-020-1372-7  0.32
2020 Goldsmith JR, Spitofsky N, Zamani A, Hood R, Boggs A, Li X, Li M, Reiner E, Ayyaz A, Etwebi Z, Lu L, Rivera Guzman J, Bou-Dargham MJ, Cathoupolis T, Hakonarson H, ... ... Wrana JL, et al. TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling. Nature Communications. 11: 2591. PMID 32444641 DOI: 10.1038/s41467-020-16379-2  0.36
2020 Sivitilli AA, Gosio JT, Ghoshal B, Evstratova A, Trcka D, Ghiasi P, Hernandez JJ, Beaulieu JM, Wrana JL, Attisano L. Robust production of uniform human cerebral organoids from pluripotent stem cells. Life Science Alliance. 3. PMID 32303588 DOI: 10.26508/lsa.202000707  0.4
2019 Schmidhauser M, Renz PF, Tsikrika P, Freimann R, Wutz A, Wrana JL, Beyer TA. Gaining Insights into the Function of Post-Translational Protein Modification Using Genome Engineering and Molecular Cell Biology. Journal of Molecular Biology. 431: 3920-3932. PMID 31306665 DOI: 10.1016/j.jmb.2019.07.015  0.32
2019 Luo Y, Barrios-Rodiles M, Gupta GD, Zhang YY, Ogunjimi AA, Bashkurov M, Tkach JM, Underhill AQ, Zhang L, Bourmoum M, Wrana JL, Pelletier L. Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility. Nature Communications. 10: 2356. PMID 31142743 DOI: 10.1038/s41467-019-10241-w  0.6
2019 Ayyaz A, Kumar S, Sangiorgi B, Ghoshal B, Gosio J, Ouladan S, Fink M, Barutcu S, Trcka D, Shen J, Chan K, Wrana JL, Gregorieff A. Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature. PMID 31019301 DOI: 10.1038/s41586-019-1154-y  0.48
2019 Shakiba N, Fahmy A, Jayakumaran G, McGibbon S, David L, Trcka D, Elbaz J, Puri MC, Nagy A, van der Kooy D, Goyal S, Wrana JL, Zandstra PW. Cell competition during reprogramming gives rise to dominant clones. Science (New York, N.Y.). PMID 30898844 DOI: 10.1126/science.aan0925  0.44
2018 Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, ... ... Wrana JL, et al. A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. Nature Communications. 9: 3510. PMID 30158528 DOI: 10.1038/s41467-018-05939-2  0.52
2018 Koefoed K, Skat-Rørdam J, Andersen P, Warzecha CB, Pye M, Andersen TA, Ajbro KD, Bendsen E, Narimatsu M, Vilhardt F, Pedersen LB, Wrana JL, Anderson RH, Møllgård K, Christensen ST, et al. The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development. Scientific Reports. 8: 9542. PMID 29934521 DOI: 10.1038/s41598-018-27854-8  0.44
2018 Bin NR, Ma K, Harada H, Tien CW, Bergin F, Sugita K, Luyben TT, Narimatsu M, Jia Z, Wrana JL, Monnier PP, Zhang L, Okamoto K, Sugita S. Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons. Cell Reports. 23: 2955-2966. PMID 29874582 DOI: 10.1016/j.celrep.2018.05.026  0.52
2017 Tassew NG, Charish J, Shabanzadeh AP, Luga V, Harada H, Farhani N, D'Onofrio P, Choi B, Ellabban A, Nickerson PEB, Wallace VA, Koeberle PD, Wrana JL, Monnier PP. Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS. Cell Reports. 20: 99-111. PMID 28683327 DOI: 10.1016/j.celrep.2017.06.009  1
2017 Ayyaz A, Attisano L, Wrana JL. Recent advances in understanding contextual TGFβ signaling. F1000research. 6: 749. PMID 28649369 DOI: 10.12688/f1000research.11295.1  0.4
2017 Barrios-Rodiles M, Ellis JD, Blencowe BJ, Wrana JL. LUMIER: A Discovery Tool for Mammalian Protein Interaction Networks. Methods in Molecular Biology (Clifton, N.J.). 1550: 137-148. PMID 28188528 DOI: 10.1007/978-1-4939-6747-6_11  0.6
2017 Han H, Braunschweig U, Gonatopoulos-Pournatzis T, Weatheritt RJ, Hirsch CL, Ha KC, Radovani E, Nabeel-Shah S, Sterne-Weiler T, Wang J, O'Hanlon D, Pan Q, Ray D, Zheng H, Vizeacoumar F, ... ... Wrana JL, et al. Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors. Molecular Cell. 65: 539-553.e7. PMID 28157508 DOI: 10.1016/j.molcel.2017.01.011  0.36
2016 Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, ... ... Wrana JL, et al. Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. The Journal of Clinical Investigation. PMID 27797343 DOI: 10.1172/JCI87802  0.44
2016 Zhang L, Wrana JL. Regulation of Rho GTPases from the lateral sides of migrating cells. Small Gtpases. 0. PMID 27657886 DOI: 10.1080/21541248.2016.1234430  0.52
2016 Rotin LE, MacLean N, Aman A, Gronda M, Lin FH, Hurren R, Wang X, Wrana JL, Datti A, Al-Awar R, Minden MD, Schimmer AD. Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. Haematologica. PMID 27587383 DOI: 10.3324/haematol.2016.146894  0.44
2016 Campbell CI, Samavarchi-Tehrani P, Barrios-Rodiles M, Datti A, Gingras AC, Wrana JL. The RNF146/Tankyrase pathway maintains the junctional Crumbs complex through regulation of Angiomotin. Journal of Cell Science. PMID 27521426 DOI: 10.1242/jcs.188417  0.76
2016 Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nature Communications. 7: 12309. PMID 27480037 DOI: 10.1038/ncomms12309  0.76
2016 Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C, Ameroso D, Abiko K, Hwang Y, Gregorieff A, Wrana JL, Asmani M, Zhao R, Sim FJ, Wrabetz L, et al. YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells. Nature Neuroscience. PMID 27273766 DOI: 10.1038/nn.4316  0.76
2016 Zhang L, Luga V, Armitage SK, Musiol M, Won A, Yip CM, Plotnikov SV, Wrana JL. A lateral signalling pathway coordinates shape volatility during cell migration. Nature Communications. 7: 11714. PMID 27226243 DOI: 10.1038/ncomms11714  0.76
2016 Lun X, Wells JC, Grinshtein N, King JC, Hao X, Dang NH, Wang X, Aman A, Uehling D, Datti A, Wrana JL, Easaw JC, Luchman A, Weiss S, Cairncross JG, et al. Disulfiram when combined with copper enhances the therapeutic effects of temozolomide for the treatment of Glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27006494 DOI: 10.1158/1078-0432.CCR-15-1798  0.44
2016 Szeto SG, Narimatsu M, Lu M, He X, Sidiqi AM, Tolosa MF, Chan L, De Freitas K, Bialik JF, Majumder S, Boo S, Hinz B, Dan Q, Advani A, John R, ... Wrana JL, et al. YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis. Journal of the American Society of Nephrology : Jasn. PMID 26961347 DOI: 10.1681/ASN.2015050499  0.44
2016 Narimatsu M, Labibi B, Wrana JL, Attisano L. Analysis of Hippo and TGFβ signaling in polarizing epithelial cells and mouse embryos. Differentiation; Research in Biological Diversity. 91: 109-18. PMID 26803209 DOI: 10.1016/j.diff.2016.01.003  0.44
2016 Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, Wrana JL, Taylor MD, Angers S, Kenney AM. YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells. Oncogene. PMID 26725322 DOI: 10.1038/onc.2015.491  0.76
2015 Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. The Journal of Cell Biology. 211: 1177-92. PMID 26668327 DOI: 10.1083/jcb.201501089  0.76
2015 Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ. TCF1 links GIPR signaling to the control of beta cell function and survival. Nature Medicine. PMID 26642437 DOI: 10.1038/nm.3997  0.76
2015 Rotin LE, Gronda M, MacLean N, Hurren R, Wang X, Lin FH, Wrana J, Datti A, Barber DL, Minden MD, Slassi M, Schimmer AD. Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism. Oncotarget. PMID 26624983 DOI: 10.18632/oncotarget.6409  0.44
2015 Gregorieff A, Liu Y, Inanlou MR, Khomchuk Y, Wrana JL. Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. Nature. 526: 715-8. PMID 26503053 DOI: 10.1038/nature15382  0.76
2015 Shnitsar I, Bashkurov M, Masson GR, Ogunjimi AA, Mosessian S, Cabeza EA, Hirsch CL, Trcka D, Gish G, Jiao J, Wu H, Winklbauer R, Williams RL, Pelletier L, Wrana JL, et al. PTEN regulates cilia through Dishevelled. Nature Communications. 6: 8388. PMID 26399523 DOI: 10.1038/ncomms9388  0.76
2015 Cassar PA, Carpenedo RL, Samavarchi-Tehrani P, Olsen JB, Park CJ, Chang WY, Chen Z, Choey C, Delaney S, Guo H, Guo H, Tanner RM, Perkins TJ, Tenenbaum SA, Emili A, ... Wrana JL, et al. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Embo Reports. 16: 1334-57. PMID 26265008 DOI: 10.15252/embr.201540974  0.76
2015 Hirsch CL, Akdemir ZC, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, ... ... Wrana JL, et al. Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes & Development. 29: 1341. PMID 26109054 DOI: 10.1101/gad.266601.115  0.36
2015 Lee EA, Angka L, Rota SG, Hanlon T, Mitchell A, Hurren R, Wang XM, Gronda M, Boyaci E, Bojko B, Minden M, Sriskanthadevan S, Datti A, Wrana JL, Edginton A, et al. Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death. Cancer Research. 75: 2478-88. PMID 26077472 DOI: 10.1158/0008-5472.CAN-14-2676  0.76
2015 Shathasivam P, Kollara A, Ringuette MJ, Virtanen C, Wrana JL, Brown TJ. Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America. 112: E3000-9. PMID 26039994 DOI: 10.1073/pnas.1504671112  0.76
2015 Abou El Hassan M, Huang K, Eswara MB, Zhao M, Song L, Yu T, Liu Y, Liu JC, McCurdy S, Ma A, Wither J, Jin J, Zacksenhaus E, Wrana JL, Bremner R. Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways. Plos One. 10: e0126466. PMID 26030458 DOI: 10.1371/journal.pone.0126466  0.76
2015 Hirsch CL, Coban Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, ... ... Wrana JL, et al. Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes & Development. 29: 803-16. PMID 25877919 DOI: 10.1101/gad.255109.114  0.76
2015 So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, ... Wrana JL, et al. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Science Signaling. 8: rs3. PMID 25852190 DOI: 10.1126/scisignal.2005700  0.76
2015 Bernard D, Gebbia M, Prabha S, Gronda M, MacLean N, Wang X, Hurren R, Sukhai MA, Cho EE, Manolson MF, Datti A, Wrana J, Minden MD, Al-Awar R, Aman A, et al. Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells. Apoptosis : An International Journal On Programmed Cell Death. 20: 948-59. PMID 25832785 DOI: 10.1007/s10495-015-1123-3  0.76
2015 Narimatsu M, Samavarchi-Tehrani P, Varelas X, Wrana JL. Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling. Developmental Cell. 32: 652-6. PMID 25758863 DOI: 10.1016/j.devcel.2015.02.019  0.44
2014 Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallières M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, et al. A highly conserved program of neuronal microexons is misregulated in autistic brains. Cell. 159: 1511-23. PMID 25525873 DOI: 10.1016/j.cell.2014.11.035  0.76
2014 Liu Y, Noon AP, Aguiar Cabeza E, Shen J, Kuk C, Ilczynski C, Ni R, Sukhu B, Chan K, Barbosa-Morais NL, Hermanns T, Blencowe BJ, Azad A, van der Kwast TH, Catto JW, ... ... Wrana JL, et al. Next-generation RNA sequencing of archival formalin-fixed paraffin-embedded urothelial bladder cancer. European Urology. 66: 982-6. PMID 25199720 DOI: 10.1016/j.eururo.2014.07.045  0.76
2014 Jeon J, Nim S, Teyra J, Datti A, Wrana JL, Sidhu SS, Moffat J, Kim PM. A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening. Genome Medicine. 6: 57. PMID 25165489 DOI: 10.1186/s13073-014-0057-7  0.32
2014 Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, ... Wrana JL, et al. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nature Cell Biology. 16: 889-901. PMID 25150980 DOI: 10.1038/ncb3021  0.76
2014 Kittanakom S, Barrios-Rodiles M, Petschnigg J, Arnoldo A, Wong V, Kotlyar M, Heisler LE, Jurisica I, Wrana JL, Nislow C, Stagljar I. CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor. Biochemical and Biophysical Research Communications. 445: 746-56. PMID 24561123 DOI: 10.1016/j.bbrc.2014.02.033  0.76
2014 Xu G, Barrios-Rodiles M, Jerkic M, Turinsky AL, Nadon R, Vera S, Voulgaraki D, Wrana JL, Toporsian M, Letarte M. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Molecular & Cellular Proteomics : McP. 13: 489-502. PMID 24319055 DOI: 10.1074/mcp.M113.033464  0.76
2013 Beyer TA, Weiss A, Khomchuk Y, Huang K, Ogunjimi AA, Varelas X, Wrana JL. Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells. Cell Reports. 5: 1611-24. PMID 24332857 DOI: 10.1016/j.celrep.2013.11.021  0.76
2013 Luga V, Wrana JL. Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis. Cancer Research. 73: 6843-7. PMID 24265274 DOI: 10.1158/0008-5472.CAN-13-1791  1
2013 Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H, Gingras AC. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Science Signaling. 6: rs15. PMID 24255178 DOI: 10.1126/scisignal.2004712  0.76
2013 Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, ... ... Wrana J, et al. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Molecular Systems Biology. 9: 696. PMID 24104479 DOI: 10.1038/msb.2013.54  0.76
2013 Attisano L, Wrana JL. Signal integration in TGF-β, WNT, and Hippo pathways. F1000prime Reports. 5: 17. PMID 23755364 DOI: 10.12703/P5-17  0.4
2013 Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, David L, Golipour A, Gabut M, Michael IP, Nachman EN, Wang E, Trcka D, Thompson T, O'Hanlon D, Slobodeniuc V, ... ... Wrana JL, et al. MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature. 498: 241-5. PMID 23739326 DOI: 10.1038/nature12270  0.76
2013 Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H. Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. Plos Genetics. 9: e1003380. PMID 23555292 DOI: 10.1371/journal.pgen.1003380  0.76
2013 Spagnuolo PA, Hurren R, Gronda M, Maclean N, Datti A, Basheer A, Lin FH, Wang X, Wrana J, Schimmer AD. Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity Leukemia. 27: 1236-1244. PMID 23318959 DOI: 10.1038/leu.2013.9  0.76
2013 Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, MacLean N, Cho EE, ... ... Wrana J, et al. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors Journal of Clinical Investigation. 123: 315-328. PMID 23202731 DOI: 10.1172/JCI64180  0.76
2013 Beyer TA, Narimatsu M, Weiss A, David L, Wrana JL. The TGFβ superfamily in stem cell biology and early mammalian embryonic development. Biochimica Et Biophysica Acta. 1830: 2268-79. PMID 22967760 DOI: 10.1016/j.bbagen.2012.08.025  0.76
2012 Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL. Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell. 151: 1542-56. PMID 23260141 DOI: 10.1016/j.cell.2012.11.024  1
2012 Golipour A, David L, Liu Y, Jayakumaran G, Hirsch CL, Trcka D, Wrana JL. A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network. Cell Stem Cell. 11: 769-82. PMID 23217423 DOI: 10.1016/j.stem.2012.11.008  0.76
2012 Attisano L, Wrana JL. The return of Dr Jekyll in cancer metastasis. The Embo Journal. 31: 4486-7. PMID 23188084 DOI: 10.1038/emboj.2012.316  0.4
2012 Ellis JD, Barrios-Rodiles M, Colak R, Irimia M, Kim T, Calarco JA, Wang X, Pan Q, O'Hanlon D, Kim PM, Wrana JL, Blencowe BJ. Tissue-specific alternative splicing remodels protein-protein interaction networks. Molecular Cell. 46: 884-92. PMID 22749401 DOI: 10.1016/j.molcel.2012.05.037  0.76
2012 Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM, Sircoulomb F, Medrano M, Fedyshyn Y, Koh JL, van Dyk D, Fedyshyn B, Luhova M, Brito GC, Vizeacoumar FJ, ... ... Wrana JL, et al. Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discovery. 2: 172-89. PMID 22585861 DOI: 10.1158/2159-8290.CD-11-0224  0.76
2012 Li J, Liu Y, Xin X, Kim TS, Cabeza EA, Ren J, Nielsen R, Wrana JL, Zhang Z. Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution. Plos Genetics. 8: e1002578. PMID 22457636 DOI: 10.1371/journal.pgen.1002578  0.76
2012 Klüppel M, Samavarchi-Tehrani P, Liu K, Wrana JL, Hinek A. C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome. European Journal of Human Genetics : Ejhg. 20: 870-7. PMID 22317973 DOI: 10.1038/ejhg.2012.12  0.44
2012 McDermott SP, Eppert K, Notta F, Isaac M, Datti A, Al-Awar R, Wrana J, Minden MD, Dick JE. A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside. Blood. 119: 1200-7. PMID 22160482 DOI: 10.1182/blood-2011-01-330019  0.76
2012 Daulat AM, Luu O, Sing A, Zhang L, Wrana JL, McNeill H, Winklbauer R, Angers S. Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation. Molecular and Cellular Biology. 32: 173-85. PMID 22037766 DOI: 10.1128/MCB.06320-11  0.76
2012 Ogunjimi AA, Zeqiraj E, Ceccarelli DF, Sicheri F, Wrana JL, David L. Structural basis for specificity of TGFβ family receptor small molecule inhibitors Cellular Signalling. 24: 476-483. PMID 21983015 DOI: 10.1016/j.cellsig.2011.09.027  0.76
2011 David L, Samavarchi-Tehrani P, Golipour A, Wrana JL. Looking into the black box: insights into the mechanisms of somatic cell reprogramming. Genes. 2: 81-106. PMID 24710139 DOI: 10.3390/genes2010081  0.44
2011 Orvedahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, et al. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature. 480: 113-7. PMID 22020285 DOI: 10.1038/nature10546  0.76
2011 Song S, Christova T, Perusini S, Alizadeh S, Bao RY, Miller BW, Hurren R, Jitkova Y, Gronda M, Isaac M, Joseph B, Subramaniam R, Aman A, Chau A, Hogge DE, ... ... Wrana JL, et al. Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers. Cancer Research. 71: 7628-39. PMID 22009536 DOI: 10.1158/0008-5472.CAN-11-2745  0.76
2011 Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, ... ... Wrana JL, et al. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 147: 132-46. PMID 21924763 DOI: 10.1016/j.cell.2011.08.023  0.76
2011 Page BD, Fletcher S, Yue P, Li Z, Zhang X, Sharmeen S, Datti A, Wrana JL, Trudel S, Schimmer AD, Turkson J, Gunning PT. Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorganic & Medicinal Chemistry Letters. 21: 5605-9. PMID 21788134 DOI: 10.1016/j.bmcl.2011.06.056  0.76
2011 Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, ... ... Wrana J, et al. An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell. 145: 1075-87. PMID 21683433 DOI: 10.1016/j.cell.2011.05.039  0.76
2011 Huang T, David L, Mendoza V, Yang Y, Villarreal M, De K, Sun L, Fang X, López-Casillas F, Wrana JL, Hinck AP. TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs. The Embo Journal. 30: 1263-76. PMID 21423151 DOI: 10.1038/emboj.2011.54  0.76
2011 Eberhard Y, Gronda M, Hurren R, Datti A, MacLean N, Ketela T, Moffat J, Wrana JL, Schimmer AD. Inhibition of SREBP1 sensitizes cells to death ligands Oncotarget. 2: 186-196. PMID 21406729  0.76
2011 Grinshtein N, Datti A, Fujitani M, Uehling D, Prakesch M, Isaac M, Irwin MS, Wrana JL, Al-Awar R, Kaplan DR. Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Cancer Research. 71: 1385-95. PMID 21303981 DOI: 10.1158/0008-5472.CAN-10-2484  0.76
2011 Ito E, Yue S, Moriyama EH, Hui AB, Kim I, Shi W, Alajez NM, Bhogal N, Li G, Datti A, Schimmer AD, Wilson BC, Liu PP, Durocher D, Neel BG, ... ... Wrana J, et al. Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Science Translational Medicine. 3: 67ra7. PMID 21270338 DOI: 10.1126/scitranslmed.3001922  0.76
2010 Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, Rossant J, Wrana JL. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Developmental Cell. 19: 831-44. PMID 21145499 DOI: 10.1016/j.devcel.2010.11.012  0.76
2010 Liu G, Zhang J, Larsen B, Stark C, Breitkreutz A, Lin ZY, Breitkreutz BJ, Ding Y, Colwill K, Pasculescu A, Pawson T, Wrana JL, Nesvizhskii AI, Raught B, Tyers M, et al. ProHits: integrated software for mass spectrometry-based interaction proteomics. Nature Biotechnology. 28: 1015-7. PMID 20944583 DOI: 10.1038/nbt1010-1015  0.76
2010 Chong PA, Lin H, Wrana JL, Forman-Kay JD. Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity. Proceedings of the National Academy of Sciences of the United States of America. 107: 18404-9. PMID 20937913 DOI: 10.1073/pnas.1003023107  0.76
2010 Smith KM, Datti A, Fujitani M, Grinshtein N, Zhang L, Morozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, ... Wrana JL, et al. Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. Embo Molecular Medicine. 2: 371-84. PMID 20721990 DOI: 10.1002/emmm.201000093  0.76
2010 Sharmeen S, Skrtic M, Sukhai MA, Hurren R, Gronda M, Wang X, Fonseca SB, Sun H, Wood TE, Ward R, Minden MD, Batey RA, Datti A, Wrana J, Kelley SO, et al. The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells. Blood. 116: 3593-603. PMID 20644115 DOI: 10.1182/blood-2010-01-262675  0.76
2010 Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A, Woltjen K, Nagy A, Wrana JL. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell. 7: 64-77. PMID 20621051 DOI: 10.1016/j.stem.2010.04.015  0.76
2010 Gumienny TL, Macneil L, Zimmerman CM, Wang H, Chin L, Wrana JL, Padgett RW. Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling. Plos Genetics. 6: e1000963. PMID 20502686 DOI: 10.1371/journal.pgen.1000963  0.76
2010 Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L. The Hippo pathway regulates Wnt/beta-catenin signaling. Developmental Cell. 18: 579-91. PMID 20412773 DOI: 10.1016/j.devcel.2010.03.007  0.76
2010 Viloria-Petit AM, Wrana JL. The TGFbeta-Par6 polarity pathway: linking the Par complex to EMT and breast cancer progression. Cell Cycle (Georgetown, Tex.). 9: 623-4. PMID 20107326 DOI: 10.4161/cc.9.4.10779  0.32
2010 Garamszegi N, Garamszegi SP, Samavarchi-Tehrani P, Walford E, Schneiderbauer MM, Wrana JL, Scully SP. Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics. Oncogene. 29: 2368-80. PMID 20101206 DOI: 10.1038/onc.2009.514  0.44
2010 Ogunjimi AA, Wiesner S, Briant DJ, Varelas X, Sicheri F, Forman-Kay J, Wrana JL. The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. The Journal of Biological Chemistry. 285: 6308-15. PMID 20026602 DOI: 10.1074/jbc.M109.044537  0.76
2009 Willis CM, Wrana JL, Klüppel M. Identification and characterization of TGFbeta-dependent and -independent cis-regulatory modules in the C4ST-1/CHST11 locus. Genetics and Molecular Research : Gmr. 8: 1331-43. PMID 19937589 DOI: 10.4238/vol8-4gmr673  0.76
2009 Miller BW, Lau G, Grouios C, Mollica E, Barrios-Rodiles M, Liu Y, Datti A, Morris Q, Wrana JL, Attisano L. Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Molecular Systems Biology. 5: 315. PMID 19888210 DOI: 10.1038/msb.2009.72  0.76
2009 Viloria-Petit AM, David L, Jia JY, Erdemir T, Bane AL, Pinnaduwage D, Roncari L, Narimatsu M, Bose R, Moffat J, Wong JW, Kerbel RS, O'Malley FP, Andrulis IL, Wrana JL. A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 106: 14028-33. PMID 19667198 DOI: 10.1073/pnas.0906796106  0.6
2009 Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, Wood TE, Hurren R, Datti A, Batey RA, Wrana J, Antholine WE, Dick JE, Dick J, Schimmer AD. Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood. 114: 3064-73. PMID 19589922 DOI: 10.1182/blood-2009-03-209965  0.76
2009 Sopko R, Silva E, Clayton L, Gardano L, Barrios-Rodiles M, Wrana J, Varelas X, Arbouzova NI, Shaw S, Saburi S, Matakatsu H, Blair S, McNeill H. Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown. Current Biology : Cb. 19: 1112-7. PMID 19540118 DOI: 10.1016/j.cub.2009.05.049  0.76
2009 Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, Sakuma R, Luga V, Roncari L, Attisano L, Wrana JL. Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 137: 295-307. PMID 19379695 DOI: 10.1016/j.cell.2009.02.025  1
2009 Luga V, McLean S, Le Roy C, O'Connor-McCourt M, Wrana JL, Di Guglielmo GM. The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning. The Biochemical Journal. 421: 119-31. PMID 19356148 DOI: 10.1042/BJ20081131  0.76
2009 Simpson CD, Mawji IA, Anyiwe K, Williams MA, Wang X, Venugopal AL, Gronda M, Hurren R, Cheng S, Serra S, Beheshti Zavareh R, Datti A, Wrana JL, Ezzat S, Schimmer AD. Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation. Cancer Research. 69: 2739-47. PMID 19293189 DOI: 10.1158/0008-5472.CAN-08-2530  0.76
2009 Taylor IW, Linding R, Warde-Farley D, Liu Y, Pesquita C, Faria D, Bull S, Pawson T, Morris Q, Wrana JL. Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nature Biotechnology. 27: 199-204. PMID 19182785 DOI: 10.1038/nbt.1522  0.76
2009 Braun P, Tasan M, Dreze M, Barrios-Rodiles M, Lemmens I, Yu H, Sahalie JM, Murray RR, Roncari L, de Smet AS, Venkatesan K, Rual JF, Vandenhaute J, Cusick ME, Pawson T, ... ... Wrana JL, et al. An experimentally derived confidence score for binary protein-protein interactions. Nature Methods. 6: 91-7. PMID 19060903 DOI: 10.1038/nmeth.1281  0.76
2008 Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, ... ... Wrana J, et al. Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Research. 68: 6688-97. PMID 18701493 DOI: 10.1158/0008-5472.CAN-07-6833  0.76
2008 Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nature Cell Biology. 10: 837-48. PMID 18568018 DOI: 10.1038/ncb1748  0.76
2008 Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Beheshti Zavareh R, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, et al. Cyproheptadine displays preclinical activity in myeloma and leukemia. Blood. 112: 760-9. PMID 18502826 DOI: 10.1182/blood-2008-02-142687  0.76
2008 Townsend TA, Wrana JL, Davis GE, Barnett JV. Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA. The Journal of Biological Chemistry. 283: 13834-41. PMID 18343818 DOI: 10.1074/jbc.M710607200  0.76
2008 Silvestri C, Narimatsu M, von Both I, Liu Y, Tan NB, Izzi L, McCaffery P, Wrana JL, Attisano L. Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Developmental Cell. 14: 411-23. PMID 18331719 DOI: 10.1016/j.devcel.2008.01.004  0.76
2008 Groppe J, Hinck CS, Samavarchi-Tehrani P, Zubieta C, Schuermann JP, Taylor AB, Schwarz PM, Wrana JL, Hinck AP. Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Molecular Cell. 29: 157-68. PMID 18243111 DOI: 10.1016/j.molcel.2007.11.039  0.76
2008 Xu GW, Mawji IA, Macrae CJ, Koch CA, Datti A, Wrana JL, Dennis JW, Schimmer AD. A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis : An International Journal On Programmed Cell Death. 13: 413-22. PMID 18181020 DOI: 10.1007/s10495-007-0175-4  0.76
2007 Mao X, Stewart AK, Hurren R, Datti A, Zhu X, Zhu Y, Shi C, Lee K, Tiedemann R, Eberhard Y, Trudel S, Liang S, Corey SJ, Gillis LC, Barber DL, ... Wrana JL, et al. A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin. Blood. 110: 4047-54. PMID 17875808 DOI: 10.1182/blood-2007-05-088666  0.76
2007 Mawji IA, Simpson CD, Gronda M, Williams MA, Hurren R, Henderson CJ, Datti A, Wrana JL, Schimmer AD. A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Research. 67: 8307-15. PMID 17804746 DOI: 10.1158/0008-5472.CAN-07-1687  0.76
2007 Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell. 130: 651-62. PMID 17719543 DOI: 10.1016/j.cell.2007.06.050  0.76
2007 Izzi L, Silvestri C, von Both I, Labbé E, Zakin L, Wrana JL, Attisano L. Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. The Embo Journal. 26: 3132-43. PMID 17568773 DOI: 10.1038/sj.emboj.7601753  0.76
2007 Gumienny TL, MacNeil LT, Wang H, de Bono M, Wrana JL, Padgett RW. Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Current Biology : Cb. 17: 159-64. PMID 17240342 DOI: 10.1016/j.cub.2006.11.065  0.76
2007 Savas S, Taylor IW, Wrana JL, Ozcelik H. Functional nonsynonymous single nucleotide polymorphisms from the TGF-beta protein interaction network. Physiological Genomics. 29: 109-17. PMID 17190851 DOI: 10.1152/physiolgenomics.00226.2006  0.76
2006 Chong PA, Lin H, Wrana JL, Forman-Kay JD. An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. The Journal of Biological Chemistry. 281: 17069-75. PMID 16641086 DOI: 10.1074/jbc.M601493200  0.76
2006 Wang HR, Ogunjimi AA, Zhang Y, Ozdamar B, Bose R, Wrana JL. Degradation of RhoA by Smurf1 ubiquitin ligase. Methods in Enzymology. 406: 437-47. PMID 16472676 DOI: 10.1016/S0076-6879(06)06032-0  0.32
2005 Klüppel M, Wight TN, Chan C, Hinek A, Wrana JL. Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development (Cambridge, England). 132: 3989-4003. PMID 16079159 DOI: 10.1242/dev.01948  0.44
2005 Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain Molecular Cell. 19: 297-308. PMID 16061177 DOI: 10.1016/j.molcel.2005.06.028  0.76
2005 Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, ... ... Wrana JL, et al. High-throughput mapping of a dynamic signaling network in mammalian cells. Science (New York, N.Y.). 307: 1621-5. PMID 15761153 DOI: 10.1126/science.1105776  0.76
2005 Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science (New York, N.Y.). 307: 1603-9. PMID 15761148 DOI: 10.1126/science.1105718  0.76
2005 Klüppel M, Wrana JL. Turning it up a Notch: cross-talk between TGF beta and Notch signaling. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 27: 115-8. PMID 15666349 DOI: 10.1002/bies.20187  0.44
2004 Lee-Hoeflich ST, Causing CG, Podkowa M, Zhao X, Wrana JL, Attisano L. Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. The Embo Journal. 23: 4792-801. PMID 15538389 DOI: 10.1038/sj.emboj.7600418  0.4
2004 Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG. Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature. 432: 107-12. PMID 15525990 DOI: 10.1038/nature03071  0.76
2004 Swallow CJ, Partridge EA, Macmillan JC, Tajirian T, DiGuglielmo GM, Hay K, Szweras M, Jahnen-Dechent W, Wrana JL, Redston M, Gallinger S, Dennis JW. alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression. Cancer Research. 64: 6402-9. PMID 15374947 DOI: 10.1158/0008-5472.CAN-04-1117  0.76
2004 von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL. Foxh1 is essential for development of the anterior heart field. Developmental Cell. 7: 331-45. PMID 15363409 DOI: 10.1016/j.devcel.2004.07.023  0.76
2004 Chong PA, Ozdamar B, Wrana JL, Forman-Kay JD. Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity. The Journal of Biological Chemistry. 279: 40707-14. PMID 15231848 DOI: 10.1074/jbc.M404375200  0.76
2004 Kimura Y, Jones N, Klüppel M, Hirashima M, Tachibana K, Cohn JB, Wrana JL, Pawson T, Bernstein A. Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proceedings of the National Academy of Sciences of the United States of America. 101: 6015-20. PMID 15067126 DOI: 10.1073/pnas.0305363101  0.76
2004 Seliktar D, Zisch AH, Lutolf MP, Wrana JL, Hubbel JA. MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing Journal of Biomedical Materials Research - Part A. 68: 704-716. PMID 14986325 DOI: 10.1002/jbm.a.20091  0.76
2003 Wang HR, Zhang Y, Ozdamar B, Ogunjimi AA, Alexandrova E, Thomsen GH, Wrana JL. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science (New York, N.Y.). 302: 1775-9. PMID 14657501 DOI: 10.1126/science.1090772  0.76
2003 Xiao C, Shim JH, Klüppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes & Development. 17: 2933-49. PMID 14633973 DOI: 10.1101/gad.1145603  0.4
2003 Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Molecular and Cellular Biology. 23: 7230-42. PMID 14517293 DOI: 10.1128/MCB.23.20.7230-7242.2003  0.76
2003 Benchabane H, Wrana JL. GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. Molecular and Cellular Biology. 23: 6646-61. PMID 12944489 DOI: 10.1128/MCB.23.18.6646-6661.2003  0.76
2003 Wrana JL. Structural biology: On the wings of inhibition. Nature. 420: 613-4. PMID 12478270 DOI: 10.1038/420613a  0.32
2002 Mehra A, Wrana JL. TGF-β and the Smad signal transduction pathway Biochemistry and Cell Biology. 80: 605-622. PMID 12440701 DOI: 10.1139/o02-161  0.76
2002 Klüppel M, Vallis KA, Wrana JL. A high-throughput induction gene trap approach defines C4ST as a target of BMP signaling. Mechanisms of Development. 118: 77-89. PMID 12351172 DOI: 10.1016/S0925-4773(02)00198-3  0.44
2002 Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily. Science (New York, N.Y.). 296: 1646-7. PMID 12040180 DOI: 10.1126/science.1071809  0.4
2001 Stroschein SL, Bonni S, Wrana JL, Luo K. Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes & Development. 15: 2822-36. PMID 11691834 DOI: 10.1101/gad.912901  0.76
2001 Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL. TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nature Cell Biology. 3: 587-95. PMID 11389444 DOI: 10.1038/35078562  0.76
2000 Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Molecular Cell. 6: 1365-75. PMID 11163210 DOI: 10.1016/S1097-2765(00)00134-9  0.76
2000 Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai JI, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K. Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Molecular and Cellular Biology. 20: 9346-55. PMID 11094085 DOI: 10.1128/MCB.20.24.9346-9355.2000  0.76
2000 Hua X, Miller ZA, Benchabane H, Wrana JL, Lodish HF. Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 gene. The Journal of Biological Chemistry. 275: 33205-8. PMID 10973944 DOI: 10.1074/jbc.C000568200  0.76
2000 Shi Y. Structural basis of Smad2 recognition by the smad anchor for receptor activation Science. 287: 92-97. PMID 10615055 DOI: 10.1126/science.287.5450.92  0.48
1999 Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 400: 687-93. PMID 10458166 DOI: 10.1038/23293  0.76
1999 Hoodless PA, Tsukazaki T, Nishimatsu S, Attisano L, Wrana JL, Thomsen GH. Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus. Developmental Biology. 207: 364-79. PMID 10068469 DOI: 10.1006/DBIO.1998.9168  0.44
1999 Brummel T, Abdollah S, Haerry TE, Shimell MJ, Merriam J, Raftery L, Wrana JL, O'Connor MB. The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes & Development. 13: 98-111. PMID 9887103 DOI: 10.1101/GAD.13.1.98  0.76
1998 Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. The Journal of Biological Chemistry. 273: 25628-36. PMID 9748228 DOI: 10.1074/jbc.273.40.25628  0.36
1997 Piscione TD, Yager TD, Gupta IR, Grinfeld B, Pei Y, Attisano L, Wrana JL, Rosenblum ND. BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis. American Journal of Physiology. Renal Physiology. 273: F961-F975. PMID 29586124 DOI: 10.1152/ajprenal.1997.273.6.F961  0.4
1997 Li M, Li J, Hoodless PA, Tzukazaki T, Wrana JL, Attisano L, Tsang BK. Mothers Against Decapentaplegic-Related Protein 2 Expression in Avian Granulosa Cells Is Up-Regulated by Transforming Growth Factor β during Ovarian Follicular Development. Endocrinology. 138: 3659-3665. PMID 28200210 DOI: 10.1210/endo.138.9.5376  0.76
1996 Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL. The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell. 86: 607-17. PMID 8752215  0.4
1996 Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell. 86: 543-52. PMID 8752209 DOI: 10.1016/S0092-8674(00)80128-2  0.76
1996 Attisano L, Wrana JL, Montalvo E, Massagué J. Activation of signalling by the activin receptor complex. Molecular and Cellular Biology. 16: 1066-73. PMID 8622651 DOI: 10.1128/MCB.16.3.1066  0.76
1995 Manova K, De Leon V, Angeles M, Kalantry S, Giarré M, Attisano L, Wrana J, Bachvarova RF. mRNAs for activin receptors II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos. Mechanisms of Development. 49: 3-11. PMID 7748787 DOI: 10.1016/0925-4773(94)00295-X  0.76
1995 Vivien D, Attisano L, Wrana JL, Massagué J. Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes. The Journal of Biological Chemistry. 270: 7134-41. PMID 7706250 DOI: 10.1074/jbc.270.13.7134  0.92
1995 Letsou A, Arora K, Wrana JL, Simin K, Twombly V, Jamal J, Staehling-Hampton K, Hoffmann FM, Gelbart WM, Massagué J. Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family. Cell. 80: 899-908. PMID 7697720 DOI: 10.1016/0092-8674(95)90293-7  0.76
1995 Vivien D, Wrana JL. Ligand-induced recruitment and phosphorylation of reduced TGF-beta type I receptor. Experimental Cell Research. 221: 60-5. PMID 7589256 DOI: 10.1006/excr.1995.1352  0.92
1994 Shapiro HS, Chen J, Wrana JL, Zhang Q, Blum M, Sodek J. Characterization of porcine bone sialoprotein: primary structure and cellular expression. Matrix (Stuttgart, Germany). 13: 431-40. PMID 8309422 DOI: 10.1016/S0934-8832(11)80109-5  0.36
1994 Wrana JL, Tran H, Attisano L, Arora K, Childs SR, Massagué J, O'Connor MB. Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex Molecular and Cellular Biology. 14: 944-950. PMID 8289834 DOI: 10.1128/MCB.14.2.944  0.76
1994 Cárcamo J, Weis FM, Ventura F, Wieser R, Wrana JL, Attisano L, Massagué J. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Molecular and Cellular Biology. 14: 3810-21. PMID 8196624 DOI: 10.1128/MCB.14.6.3810  0.4
1994 Koenig BB, Cook JS, Wolsing DH, Ting J, Tiesman JP, Correa PE, Olson CA, Pecquet AL, Ventura F, Grant RA. Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Molecular and Cellular Biology. 14: 5961-74. PMID 8065329 DOI: 10.1128/MCB.14.9.5961  0.76
1994 Kim RH, Shapiro HS, Li JJ, Wrana JL, Sodek J. Characterization of the Human Bone SialoProtein (BSP) Gene and its Promoter Sequence Matrix Biology. 14: 31-40. PMID 8061918 DOI: 10.1016/0945-053X(94)90027-2  0.76
1994 Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J. Mechanism of activation of the TGF-beta receptor. Nature. 370: 341-7. PMID 8047140 DOI: 10.1038/370341a0  0.4
1994 Brummel TJ, Twombly V, Marqués G, Wrana JL, Newfeld SJ, Attisano L, Massagué J, O'Connor MB, Gelbart WM. Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell. 78: 251-61. PMID 8044839 DOI: 10.1016/0092-8674(94)90295-X  0.76
1994 Penton A, Chen Y, Staehling-Hampton K, Wrana JL, Attisano L, Szidonya J, Cassill JA, Massagué J, Hoffmann FM. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell. 78: 239-50. PMID 8044838 DOI: 10.1016/0092-8674(94)90294-1  0.76
1993 Childs SR, Wrana JL, Arora K, Attisano L, O'Connor MB, Massagué J. Identification of a Drosophila activin receptor Proceedings of the National Academy of Sciences of the United States of America. 90: 9475-9479. PMID 8415726 DOI: 10.1073/pnas.90.20.9475  0.76
1993 Wieser R, Attisano L, Wrana JL, Massagué J. Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region. Molecular and Cellular Biology. 13: 7239-47. PMID 8246946 DOI: 10.1128/MCB.13.12.7239  0.4
1992 Zhang Q, Wrana JL, Sodek J. Characterization of the promoter region of the porcine opn (osteopontin, secreted phosphoprotein 1) gene. Identification of positive and negative regulatory elements and a 'silent' second promoter. European Journal of Biochemistry. 207: 649-59. PMID 1633816 DOI: 10.1111/j.1432-1033.1992.tb17092.x  0.32
1991 Chen JK, Shapiro HS, Wrana JL, Reimers S, Heersche JN, Sodek J. Localization of bone sialoprotein (BSP) expression to sites of mineralized tissue formation in fetal rat tissues by in situ hybridization. Matrix (Stuttgart, Germany). 11: 133-43. PMID 2072878 DOI: 10.1016/S0934-8832(11)80217-9  0.4
1991 Wrana JL, Kubota T, Zhang Q, Overall CM, Aubin JE, Butler WT, Sodek J. Regulation of transformation-sensitive secreted phosphoprotein (SPPI/osteopontin) expression by transforming growth factor-beta. Comparisons with expression of SPARC (secreted acidic cysteine-rich protein). The Biochemical Journal. 273: 523-31. PMID 1996953  0.76
1991 Kasugai S, Zhang Q, Overall CM, Wrana JL, Butler WT, Sodek J. Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter. Bone and Mineral. 13: 235-50. PMID 1863811 DOI: 10.1016/0169-6009(91)90071-7  0.6
1991 Overall CM, Wrana JL, Sodek J. Induction of formative and resorptive cellular phenotypes in human gingival fibroblasts by TGF-beta 1 and concanavalin A: regulation of matrix metalloproteinases and TIMP. Journal of Periodontal Research. 26: 279-82. PMID 1831853 DOI: 10.1111/j.1600-0765.1991.tb01658.x  0.6
1991 Wrana JL, Overall CM, Sodek J. Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen. European Journal of Biochemistry. 197: 519-28. PMID 1709099 DOI: 10.1111/j.1432-1033.1991.tb15940.x  0.6
1990 Wrana JL, Zhang Q, Sodek J. Full length cDNA sequence of porcine secreted phosphoprotein-I (SPP-I, osteopontin). Nucleic Acids Research. 17: 10119. PMID 2602123 DOI: 10.1093/nar/17.23.10119  0.52
1989 Kubota T, Zhang Q, Wrana JL, Ber R, Aubin JE, Butler WT, Sodek J. Multiple forms of SppI (secreted phosphoprotein, osteopontin) synthesized by normal and transformed rat bone cell populations: regulation by TGF-beta. Biochemical and Biophysical Research Communications. 162: 1453-9. PMID 2764941 DOI: 10.1016/0006-291X(89)90837-1  0.76
1989 Overall CM, Wrana JL, Sodek J. Transforming growth factor-beta regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts. Connective Tissue Research. 20: 289-94. PMID 2558843 DOI: 10.3109/03008208909023899  0.6
1988 Wrana JL, Maeno M, Hawrylyshyn B, Yao KL, Domenicucci C, Sodek J. Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations. The Journal of Cell Biology. 106: 915-24. PMID 3162238 DOI: 10.1083/jcb.106.3.915  0.32
1986 Wrana JL, Sodek J, Ber RL, Bellows CG. The effects of platelet-derived transforming growth factor beta on normal human diploid gingival fibroblasts. European Journal of Biochemistry. 159: 69-76. PMID 3488905 DOI: 10.1111/j.1432-1033.1986.tb09834.x  0.48
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