| Year |
Citation |
Score |
| 2024 |
Landegger LD, Reisinger E, Lallemend F, Hage SR, Grimm D, Cederroth CR. The rise of cochlear gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 39520052 DOI: 10.1016/j.ymthe.2024.11.012 |
0.316 |
|
| 2024 |
Tasfaout H, Halbert CL, McMillen TS, Allen JM, Reyes TR, Flint GV, Grimm D, Hauschka SD, Regnier M, Chamberlain JS. Split intein-mediated protein trans-splicing to express large dystrophins. Nature. PMID 39020181 DOI: 10.1038/s41586-024-07710-8 |
0.371 |
|
| 2023 |
Theuerkauf SA, Herrera-Carrillo E, John F, Zinser LJ, Molina MA, Riechert V, Thalheimer FB, Börner K, Grimm D, Chlanda P, Berkhout B, Buchholz CJ. AAV vectors displaying bispecific DARPins enable dual-control targeted gene delivery. Biomaterials. 303: 122399. PMID 37992599 DOI: 10.1016/j.biomaterials.2023.122399 |
0.333 |
|
| 2023 |
Liu J, Koay TW, Maiakovska O, Zayas M, Grimm D. Progress in Bioengineering of Myotropic Adeno-Associated Viral Gene Therapy Vectors. Human Gene Therapy. 34: 350-364. PMID 37082964 DOI: 10.1089/hum.2023.057 |
0.363 |
|
| 2022 |
Rapti K, Maiakovska O, Becker J, Szumska J, Zayas M, Bubeck F, Liu J, Gerstmann E, Krämer C, Wiedtke E, Grimm D. Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants. Journal of Visualized Experiments : Jove. PMID 36342179 DOI: 10.3791/64389 |
0.383 |
|
| 2022 |
Szumska J, Grimm D. Boosters for adeno-associated virus vector (AAV) (r)evolution. Cytotherapy. PMID 35999132 DOI: 10.1016/j.jcyt.2022.07.005 |
0.381 |
|
| 2022 |
Becker J, Fakhiri J, Grimm D. Fantastic AAV Gene Therapy Vectors and How to Find Them-Random Diversification, Rational Design and Machine Learning. Pathogens (Basel, Switzerland). 11. PMID 35890005 DOI: 10.3390/pathogens11070756 |
0.409 |
|
| 2022 |
Mann AM, Schäfer W, Adriouch S, Börner K, Grimm D, Braren I, Koch-Nolte F. Enhanced Transduction of P2X7-Expressing Cells with Recombinant rAAV Vectors. Methods in Molecular Biology (Clifton, N.J.). 2510: 129-144. PMID 35776323 DOI: 10.1007/978-1-0716-2384-8_7 |
0.331 |
|
| 2022 |
Gadenstaetter AJ, Schmutzler L, Grimm D, Landegger LD. Intranasal application of adeno-associated viruses: a systematic review. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 35597541 DOI: 10.1016/j.trsl.2022.05.002 |
0.312 |
|
| 2022 |
Becker J, Stanifer ML, Leist SR, Stolp B, Maiakovska O, West A, Wiedtke E, Börner K, Ghanem A, Ambiel I, Tse LV, Fackler OT, Baric RS, Boulant S, Grimm D. Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV-RNAi expression vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 35038579 DOI: 10.1016/j.ymthe.2022.01.024 |
0.407 |
|
| 2021 |
Michels A, Frank AM, Günther DM, Mataei M, Börner K, Grimm D, Hartmann J, Buchholz CJ. Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8. Molecular Therapy. Methods & Clinical Development. 23: 334-347. PMID 34729380 DOI: 10.1016/j.omtm.2021.09.014 |
0.301 |
|
| 2021 |
Zhang C, Freistaedter A, Schmelas C, Gunkel M, Dao Thi VL, Grimm D. An RNA Interference/Adeno-Associated Virus Vector-Based Combinatorial Gene Therapy Approach Against Hepatitis E Virus. Hepatology Communications. PMID 34719133 DOI: 10.1002/hep4.1842 |
0.443 |
|
| 2021 |
Kremer LPM, Cerrizuela S, Dehler S, Stiehl T, Weinmann J, Abendroth H, Kleber S, Laure A, El Andari J, Anders S, Marciniak-Czochra A, Grimm D, Martin-Villalba A. High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zone. Molecular Therapy. Methods & Clinical Development. 23: 33-50. PMID 34553001 DOI: 10.1016/j.omtm.2021.07.001 |
0.301 |
|
| 2021 |
Fakhiri J, Grimm D. Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33831556 DOI: 10.1016/j.ymthe.2021.04.005 |
0.388 |
|
| 2021 |
Medert R, Jungmann A, Hildebrand S, Busch M, Grimm D, Flockerzi V, Müller OJ, Most P, Schumacher D, Freichel M. Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart. Pflugers Archiv : European Journal of Physiology. PMID 33580817 DOI: 10.1007/s00424-021-02521-6 |
0.312 |
|
| 2020 |
Fakhiri J, Landegger LD, Grimm D. Breaking the sound barrier: Towards next-generation AAV vectors for gene therapy of hearing disorders. Hearing Research. 108092. PMID 33268240 DOI: 10.1016/j.heares.2020.108092 |
0.332 |
|
| 2020 |
Weinmann J, Weis S, Sippel J, Tulalamba W, Remes A, El Andari J, Herrmann AK, Pham QH, Borowski C, Hille S, Schönberger T, Frey N, Lenter M, VandenDriessche T, Müller OJ, ... ... Grimm D, et al. Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants. Nature Communications. 11: 5432. PMID 33116134 DOI: 10.1038/s41467-020-19230-w |
0.386 |
|
| 2020 |
El Andari J, Grimm D. Production, Processing, and Characterization of synthetic AAV Gene Therapy Vectors. Biotechnology Journal. e2000025. PMID 32975881 DOI: 10.1002/biot.202000025 |
0.355 |
|
| 2020 |
Klein S, Müller TG, Khalid D, Sonntag-Buck V, Heuser AM, Glass B, Meurer M, Morales I, Schillak A, Freistaedter A, Ambiel I, Winter SL, Zimmermann L, Naumoska T, Bubeck F, ... ... Grimm D, et al. SARS-CoV-2 RNA Extraction Using Magnetic Beads for Rapid Large-Scale Testing by RT-qPCR and RT-LAMP. Viruses. 12. PMID 32784757 DOI: 10.3390/V12080863 |
0.355 |
|
| 2020 |
Haar J, Krämer C, Grimm D. Lab-Scale Production of Recombinant Adeno-Associated Viruses (AAV) for Expression of Optogenetic Elements. Methods in Molecular Biology (Clifton, N.J.). 2173: 83-100. PMID 32651911 DOI: 10.1007/978-1-0716-0755-8_5 |
0.48 |
|
| 2020 |
Mathony J, Harteveld Z, Schmelas C, Upmeier Zu Belzen J, Aschenbrenner S, Sun W, Hoffmann MD, Stengl C, Scheck A, Georgeon S, Rosset S, Wang Y, Grimm D, Eils R, Correia BE, et al. Computational design of anti-CRISPR proteins with improved inhibition potency. Nature Chemical Biology. PMID 32284602 DOI: 10.1038/S41589-020-0518-9 |
0.322 |
|
| 2020 |
Fakhiri J, Linse KP, Mietzsch M, Xu M, Schneider MA, Meister M, Schildgen O, Schnitzler P, Soderlund-Venermo M, Agbandje-McKenna M, Grimm D. Impact of natural or synthetic singletons in the capsid of human bocavirus 1 on particle infectivity and immunoreactivity. Journal of Virology. PMID 32213611 DOI: 10.1128/Jvi.00170-20 |
0.44 |
|
| 2020 |
Börner K, Kienle E, Huang LY, Weinmann J, Sacher A, Bayer P, Stüllein C, Fakhiri J, Zimmermann L, Westhaus A, Beneke J, Beil N, Wiedtke E, Schmelas C, Miltner D, ... ... Grimm D, et al. Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 32105604 DOI: 10.1016/J.Ymthe.2020.02.009 |
0.364 |
|
| 2020 |
Michler T, Kosinska AD, Festag J, Bunse T, Su J, Ringelhan M, Imhof H, Grimm D, Steiger K, Mogler C, Heikenwalder M, Michel ML, Guzman CA, Milstein S, Sepp-Lorenzino L, et al. Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-titer HBV Carrier Mice. Gastroenterology. PMID 32001321 DOI: 10.1053/J.Gastro.2020.01.032 |
0.381 |
|
| 2019 |
Krooss SA, Dai Z, Schmidt F, Rovai A, Fakhiri J, Dhingra A, Yuan Q, Yang T, Balakrishnan A, Steinbrück L, Srivaratharajan S, Manns MP, Schambach A, Grimm D, Bohne J, et al. Ex Vivo/In vivo Gene Editing in Hepatocytes Using "All-in-One" CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template. Iscience. 23: 100764. PMID 31887661 DOI: 10.1016/J.Isci.2019.100764 |
0.516 |
|
| 2019 |
Eichhoff AM, Börner K, Albrecht B, Schäfer W, Baum N, Haag F, Körbelin J, Trepel M, Braren I, Grimm D, Adriouch S, Koch-Nolte F. Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors. Molecular Therapy. Methods & Clinical Development. 15: 211-220. PMID 31687421 DOI: 10.1016/J.Omtm.2019.09.003 |
0.433 |
|
| 2019 |
Hentzschel F, Mitesser V, Fraschka SA, Krzikalla D, Carrillo EH, Berkhout B, Bártfai R, Mueller AK, Grimm D. Gene knockdown in malaria parasites via non-canonical RNAi. Nucleic Acids Research. PMID 31680162 DOI: 10.1093/Nar/Gkz927 |
0.419 |
|
| 2019 |
Tulalamba W, Weinmann J, Pham QH, El Andari J, VandenDriessche T, Chuah MK, Grimm D. Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors. Gene Therapy. PMID 31624368 DOI: 10.1038/S41434-019-0106-3 |
0.36 |
|
| 2019 |
Domenger C, Grimm D. Next-generation AAV vectors - don't judge a virus (only) by its cover. Human Molecular Genetics. PMID 31261383 DOI: 10.1093/Hmg/Ddz148 |
0.525 |
|
| 2019 |
Hoffmann MD, Aschenbrenner S, Grosse S, Rapti K, Domenger C, Fakhiri J, Mastel M, Börner K, Eils R, Grimm D, Niopek D. Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins. Nucleic Acids Research. PMID 30982889 DOI: 10.1093/Nar/Gkz271 |
0.343 |
|
| 2019 |
Fakhiri J, Nickl M, Grimm D. Rapid and Simple Screening of CRISPR Guide RNAs (gRNAs) in Cultured Cells Using Adeno-Associated Viral (AAV) Vectors. Methods in Molecular Biology (Clifton, N.J.). 1961: 111-126. PMID 30912043 DOI: 10.1007/978-1-4939-9170-9_8 |
0.493 |
|
| 2019 |
Fakhiri J, Schneider MA, Puschhof J, Stanifer M, Schildgen V, Holderbach S, Voss Y, El Andari J, Schildgen O, Boulant S, Meister M, Clevers H, Yan Z, Qiu J, Grimm D. Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses. Molecular Therapy. Methods & Clinical Development. 12: 202-222. PMID 30766894 DOI: 10.1016/J.Omtm.2019.01.003 |
0.493 |
|
| 2019 |
Fanucchi S, Fok ET, Dalla E, Shibayama Y, Börner K, Chang EY, Stoychev S, Imakaev M, Grimm D, Wang KC, Li G, Sung WK, Mhlanga MM. Publisher Correction: Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments. Nature Genetics. PMID 30647470 DOI: 10.1038/S41588-018-0341-3 |
0.308 |
|
| 2018 |
Fanucchi S, Fok ET, Dalla E, Shibayama Y, Börner K, Chang EY, Stoychev S, Imakaev M, Grimm D, Wang KC, Li G, Sung WK, Mhlanga MM. Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments. Nature Genetics. PMID 30531872 DOI: 10.1038/S41588-018-0298-2 |
0.346 |
|
| 2018 |
Herrmann AK, Bender C, Kienle E, Grosse S, El Andari J, Botta J, Schürmann N, Wiedtke E, Niopek D, Grimm D. A robust and all-inclusive pipeline for shuffling of Adeno-associated viruses (AAV). Acs Synthetic Biology. PMID 30513195 DOI: 10.1021/Acssynbio.8B00373 |
0.436 |
|
| 2018 |
Bubeck F, Hoffmann MD, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer MC, Börner K, Fakhiri J, Schmelas C, Dietz L, Grimm D, Correia BE, Eils R, Niopek D. Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9. Nature Methods. 15: 924-927. PMID 30377362 DOI: 10.1038/S41592-018-0178-9 |
0.319 |
|
| 2018 |
Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, Fronza R, Landerer H, Abad M, Niopek D, Schmidt M, Serrano M, Grimm D. AAVvector-mediated in vivo reprogramming into pluripotency. Nature Communications. 9: 2651. PMID 29985406 DOI: 10.1038/S41467-018-05059-X |
0.457 |
|
| 2018 |
Herrmann AK, Grosse S, Börner K, Krämer C, Wiedtke E, Gunkel M, Grimm D. Impact of the assembly-activating protein (AAP) on molecular evolution of synthetic Adeno-associated virus (AAV) capsids. Human Gene Therapy. PMID 29978729 DOI: 10.1089/Hum.2018.085 |
0.496 |
|
| 2018 |
Herrmann AK, Grimm D. High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious. Journal of Molecular Biology. PMID 29782834 DOI: 10.1016/J.Jmb.2018.05.022 |
0.47 |
|
| 2018 |
Schmelas C, Grimm D. Split Cas9, not hairs - advancing the therapeutic index of CRISPR technology. Biotechnology Journal. PMID 29316283 DOI: 10.1002/Biot.201700432 |
0.458 |
|
| 2017 |
Amoasii L, Long C, Li H, Mireault AA, Shelton JM, Sanchez-Ortiz E, McAnally JR, Bhattacharyya S, Schmidt F, Grimm D, Hauschka SD, Bassel-Duby R, Olson EN. Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy. Science Translational Medicine. 9. PMID 29187645 DOI: 10.1126/Scitranslmed.Aan8081 |
0.353 |
|
| 2017 |
Kunze C, Börner K, Kienle E, Orschmann T, Rusha E, Schneider M, Radivojkov-Blagojevic M, Drukker M, Desbordes S, Grimm D, Brack-Werner R. Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes. Glia. PMID 29119608 DOI: 10.1002/Glia.23254 |
0.313 |
|
| 2017 |
Grimm D, Büning H. Small but increasingly mighty - Latest advances in AAV vector research, design and evolution. Human Gene Therapy. PMID 28835125 DOI: 10.1089/hum.2017.172 |
0.371 |
|
| 2017 |
Große S, Penaud-Budloo M, Herrmann AK, Börner K, Fakhiri J, Laketa V, Krämer C, Wiedtke E, Gunkel M, Ménard L, Ayuso E, Grimm D. Relevance of assembly-activating protein for Adeno-associated virus vector production and capsid protein stability in mammalian and insect cells. Journal of Virology. PMID 28768875 DOI: 10.1128/Jvi.01198-17 |
0.431 |
|
| 2017 |
Weinmann J, Grimm D. Next-generation AAV vectors for clinical use: an ever-accelerating race. Virus Genes. PMID 28762205 DOI: 10.1007/S11262-017-1502-7 |
0.425 |
|
| 2017 |
Pervolaraki K, Stanifer ML, Münchau S, Renn LA, Albrecht D, Kurzhals S, Senís E, Grimm D, Schröder-Braunstein J, Rabin RL, Boulant S. Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut. Frontiers in Immunology. 8: 459. PMID 28484457 DOI: 10.3389/Fimmu.2017.00459 |
0.334 |
|
| 2017 |
Lempp FA, Wiedtke E, Qu B, Roques P, Chemin I, Vondran FW, Le Grand R, Grimm D, Urban S. Sodium taurocholate cotransporting polypeptide is the limiting host factor of Hepatitis B Virus infection in macaque and pig hepatocytes. Hepatology (Baltimore, Md.). PMID 28195359 DOI: 10.1002/Hep.29112 |
0.402 |
|
| 2017 |
Sá E Cunha C, Nyboer B, Heiss K, Sanches-Vaz M, Fontinha D, Wiedtke E, Grimm D, Przyborski JM, Mota MM, Prudêncio M, Mueller AK. Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137845 DOI: 10.1073/Pnas.1606419114 |
0.359 |
|
| 2016 |
Senís E, Mockenhaupt S, Rupp D, Bauer T, Paramasivam N, Knapp B, Gronych J, Grosse S, Windisch MP, Schmidt F, Theis FJ, Eils R, Lichter P, Schlesner M, Bartenschlager R, ... Grimm D, et al. TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Research. PMID 27614072 DOI: 10.1093/Nar/Gkw805 |
0.413 |
|
| 2016 |
Michler T, Große S, Mockenhaupt S, Röder N, Stückler F, Knapp B, Ko C, Heikenwalder M, Protzer U, Grimm D. Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA. Embo Molecular Medicine. PMID 27473329 DOI: 10.15252/Emmm.201506172 |
0.526 |
|
| 2016 |
Ebrahimi-Fakhari D, Wahlster L, Bartz F, Werenbeck-Ueding J, Praggastis M, Zhang J, Joggerst-Thomalla B, Theiss S, Grimm D, Ory DS, Runz H. Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-Pick type C1 disease cells. Human Molecular Genetics. PMID 27378690 DOI: 10.1093/Hmg/Ddw204 |
0.306 |
|
| 2016 |
Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Schwabe RF, Corvera CU, Grimm D, Willenbring H. In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis. Cell Stem Cell. 18: 809-816. PMID 27257763 DOI: 10.1016/J.Stem.2016.05.005 |
0.405 |
|
| 2016 |
Hentzschel F, Herrmann AK, Mueller AK, Grimm D. Plasmodium meets AAV - the (un)likely marriage of parasitology and virology, and how to make the match. Febs Letters. PMID 27117587 DOI: 10.1002/1873-3468.12187 |
0.324 |
|
| 2016 |
Liesche C, Venkatraman L, Aschenbrenner S, Grosse S, Grimm D, Eils R, Beaudouin J. Death receptor-based enrichment of Cas9-expressing cells. Bmc Biotechnology. 16: 17. PMID 26883910 DOI: 10.1186/S12896-016-0250-4 |
0.394 |
|
| 2016 |
Wilkening S, Afzal S, Senís E, Fronza R, Kalle Cv, Grimm D, Schmidt M. 470. New Insights into rAAV Integration Mechanisms by Targeted Enrichment Sequencing Molecular Therapy. 24. DOI: 10.1016/S1525-0016(16)33279-8 |
0.374 |
|
| 2016 |
Grosse S, Penaud-Budloo M, Ayuso E, Grimm D. 302. Molecular AAV Capsid Evolution Is Not Primarily Restricted by Inadvertent Shuffling of the Assembly-Activating Protein AAP Molecular Therapy. 24. DOI: 10.1016/S1525-0016(16)33111-2 |
0.451 |
|
| 2016 |
Fakhiri J, Schneider M, Kailasan S, Meister M, McKenna MA, Yan Z, Qiu J, Grimm D. 254. New Chimeric Gene Therapy Vectors Based on Four Different Mammalian Bocaviruses Molecular Therapy. 24: S100. DOI: 10.1016/S1525-0016(16)33063-5 |
0.533 |
|
| 2016 |
Michler T, Kosinska A, Jäger C, Röder N, Grimm D, Heikenwälder M, Roggendorf M, Protzer U. RNA Interference Mediated Suppression of HBV Transcripts Restores HBV-Specific Immunity and Enhances the Efficacy of Therapeutic Vaccination Journal of Hepatology. 64: S148-S149. DOI: 10.1016/S0168-8278(16)00039-8 |
0.358 |
|
| 2015 |
Grimm D, Zolotukhin S. E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal-Tailored Acceleration of AAV Evolution. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 1819-1831. PMID 28142019 DOI: 10.1038/mt.2015.173 |
0.317 |
|
| 2015 |
Singer M, Marshall J, Heiss K, Mair GR, Grimm D, Mueller AK, Frischknecht F. Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining. Genome Biology. 16: 249. PMID 26573820 DOI: 10.1186/S13059-015-0811-1 |
0.324 |
|
| 2015 |
Grimm D, Zolotukhin S. E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal-Tailored Acceleration of AAV Evolution. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26388463 DOI: 10.1038/Mt.2015.173 |
0.428 |
|
| 2015 |
Mockenhaupt S, Grosse S, Rupp D, Bartenschlager R, Grimm D. Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys. Proceedings of the National Academy of Sciences of the United States of America. 112: E4007-16. PMID 26170322 DOI: 10.1073/Pnas.1510476112 |
0.513 |
|
| 2015 |
Mueller S, Huard J, Waldow K, Huang X, D'Alessandro LA, Bohl S, Börner K, Grimm D, Klamt S, Klingmüller U, Schilling M. T160‐phosphorylated CDK2 defines threshold for HGF dependent proliferation in primary hepatocytes. Molecular Systems Biology. 11: 795. PMID 26148348 DOI: 10.15252/Msb.20156032 |
0.326 |
|
| 2015 |
Schmidt F, Grimm D. CRISPR genome engineering and viral gene delivery: a case of mutual attraction. Biotechnology Journal. 10: 258-72. PMID 25663455 DOI: 10.1002/Biot.201400529 |
0.477 |
|
| 2015 |
Michler T, Grosse S, Mockenhaupt S, Protzer U, Grimm D. 699. shRNA Sense Strand Neutralization Reduces Off-Targeting, Ameliorates Toxicity and Enhances Efficacy of RNAi-Based HBV Gene Therapy Molecular Therapy. 23: S278. DOI: 10.1016/S1525-0016(16)34308-8 |
0.526 |
|
| 2015 |
Lederle M, Tegeler K, Cerny D, Zessin P, Grimm D. 697. New Insights Into the Mechanisms of Argonaute Protein Competition and Implications for RNAi Gene Therapies Molecular Therapy. 23. DOI: 10.1016/S1525-0016(16)34306-4 |
0.504 |
|
| 2015 |
Boerner K, Fischer E, Schnitzler P, Fortes P, Kräusslich H, Grimm D. 648. Non-Coding RNAs as Clinically Relevant Host Factors and Target Molecules in HIV-1 Infection Molecular Therapy. 23. DOI: 10.1016/S1525-0016(16)34257-5 |
0.319 |
|
| 2015 |
Boerner K, Kienle E, Sacher A, Huang L, Bechtle M, Wiedtke E, Bayer P, Kräusslich H, Agbandje-McKenna M, Grimm D. 307. Rational Development of 12 Different AAV Serotypes as Scaffolds for Peptide Display Molecular Therapy. 23. DOI: 10.1016/S1525-0016(16)33916-8 |
0.33 |
|
| 2015 |
Senís E, Mosteiro L, Wilkening S, Schmidt M, Serrano M, Grimm D. 300. AAV Vector-Mediated In Vivo Reprogramming of Various Cell Types in Adult Mice Molecular Therapy. 23. DOI: 10.1016/S1525-0016(16)33909-0 |
0.521 |
|
| 2015 |
Schmidt F, Beaudouin J, Börner K, Grimm D. 117. AAV-TRISPR – A Novel Versatile AAV Vector Kit for Combinatorial CRISPR and RNAi Expression Molecular Therapy. 23. DOI: 10.1016/S1525-0016(16)33722-4 |
0.537 |
|
| 2015 |
Boerner K, Nickl M, Schmidt F, Gnirck A, Bayer P, Kräusslich H, Grimm D. 56. AAV Vector-Mediated CRISPR Attacks on Proviral HIV-1 DNA for Purging of Cellular Reservoirs Molecular Therapy. 23: S25. DOI: 10.1016/S1525-0016(16)33661-9 |
0.383 |
|
| 2015 |
Michler T, Grosse S, Mockenhaupt S, Heikenwaelder M, Grimm D, Protzer U. P0563 : RNAi-based gene therapy for chronic hepatitis B: Evaluation in a murine model Journal of Hepatology. 62: S526. DOI: 10.1016/S0168-8278(15)30770-4 |
0.354 |
|
| 2014 |
Uhrig-Schmidt S, Geiger M, Luippold G, Birk G, Mennerich D, Neubauer H, Grimm D, Wolfrum C, Kreuz S. Gene delivery to adipose tissue using transcriptionally targeted rAAV8 vectors. Plos One. 9: e116288. PMID 25551639 DOI: 10.1371/Journal.Pone.0116288 |
0.441 |
|
| 2014 |
Carnero E, Barriocanal M, Segura V, Guruceaga E, Prior C, Börner K, Grimm D, Fortes P. Type I Interferon Regulates the Expression of Long Non-Coding RNAs. Frontiers in Immunology. 5: 548. PMID 25414701 DOI: 10.3389/Fimmu.2014.00548 |
0.416 |
|
| 2014 |
Hentzschel F, Hammerschmidt-Kamper C, Börner K, Heiss K, Knapp B, Sattler JM, Kaderali L, Castoldi M, Bindman JG, Malato Y, Willenbring H, Mueller AK, Grimm D. AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 2130-41. PMID 25189739 DOI: 10.1038/Mt.2014.172 |
0.368 |
|
| 2014 |
Senís E, Fatouros C, Große S, Wiedtke E, Niopek D, Mueller AK, Börner K, Grimm D. CRISPR/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox. Biotechnology Journal. 9: 1402-12. PMID 25186301 DOI: 10.1002/Biot.201400046 |
0.539 |
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| 2014 |
Hörner M, Kaufmann B, Cotugno G, Wiedtke E, Büning H, Grimm D, Weber W. A chemical switch for controlling viral infectivity. Chemical Communications (Cambridge, England). 50: 10319-22. PMID 25058661 DOI: 10.1039/C4Cc03292F |
0.306 |
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| 2013 |
Börner K, Niopek D, Cotugno G, Kaldenbach M, Pankert T, Willemsen J, Zhang X, Schürmann N, Mockenhaupt S, Serva A, Hiet MS, Wiedtke E, Castoldi M, Starkuviene V, Erfle H, ... ... Grimm D, et al. Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines. Nucleic Acids Research. 41: e199. PMID 24049077 DOI: 10.1093/Nar/Gkt836 |
0.494 |
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| 2013 |
Schürmann N, Trabuco LG, Bender C, Russell RB, Grimm D. Molecular dissection of human Argonaute proteins by DNA shuffling. Nature Structural & Molecular Biology. 20: 818-26. PMID 23748378 DOI: 10.1038/Nsmb.2607 |
0.355 |
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| 2012 |
Grimm D, Dalmay T, van Rij RP. Everybody wins! Poland hosts thrilling competitions of viruses, RNAi and football teams. Embo Reports. 13: 874-6. PMID 22986551 DOI: 10.1038/Embor.2012.136 |
0.411 |
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| 2012 |
Grimm D. All for one, one for all: new combinatorial RNAi therapies combat hepatitis C virus evolution. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1661-3. PMID 22945230 DOI: 10.1038/Mt.2012.173 |
0.412 |
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| 2012 |
Kienle E, Senís E, Börner K, Niopek D, Wiedtke E, Grosse S, Grimm D. Engineering and evolution of synthetic adeno-associated virus (AAV) gene therapy vectors via DNA family shuffling. Journal of Visualized Experiments : Jove. PMID 22491297 DOI: 10.3791/3819 |
0.462 |
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| 2012 |
Valdmanis PN, Gu S, Schüermann N, Sethupathy P, Grimm D, Kay MA. Expression determinants of mammalian argonaute proteins in mediating gene silencing. Nucleic Acids Research. 40: 3704-13. PMID 22210886 DOI: 10.1093/Nar/Gkr1274 |
0.497 |
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| 2011 |
Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. The Journal of Clinical Investigation. 121: 4850-60. PMID 22105172 DOI: 10.1172/Jci59261 |
0.544 |
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| 2011 |
Grimm D. The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression. Silence. 2: 8. PMID 22029761 DOI: 10.1186/1758-907X-2-8 |
0.385 |
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| 2011 |
Mockenhaupt S, Schürmann N, Grimm D. When cellular networks run out of control: global dysregulation of the RNAi machinery in human pathology and therapy. Progress in Molecular Biology and Translational Science. 102: 165-242. PMID 21846572 DOI: 10.1016/B978-0-12-415795-8.00006-4 |
0.464 |
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| 2011 |
Gu S, Jin L, Zhang F, Huang Y, Grimm D, Rossi JJ, Kay MA. Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. Proceedings of the National Academy of Sciences of the United States of America. 108: 9208-13. PMID 21576459 DOI: 10.1073/Pnas.1018023108 |
0.538 |
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| 2011 |
Mockenhaupt S, Grimm D. Vectorology: Adeno-associated viruses for efficient gene targeting in human cells | Vektorologie: Adeno-assoziierte viren für effizientes gene targeting in humanen zellen Biospektrum. 17: 533-536. DOI: 10.1007/sl2268-011-0085-4 |
0.303 |
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| 2011 |
Mockenhaupt S, Grimm D. Adeno-assoziierte Viren für effizientes Gene Targeting in humanen Zellen Biospektrum. 17: 533-536. DOI: 10.1007/S12268-011-0085-4 |
0.395 |
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| 2010 |
Grimm D, Wang L, Lee JS, Schürmann N, Gu S, Börner K, Storm TA, Kay MA. Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. The Journal of Clinical Investigation. 120: 3106-19. PMID 20697157 DOI: 10.1172/Jci43565 |
0.642 |
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| 2010 |
Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, ... ... Grimm D, et al. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. Plos Pathogens. 6: e1000764. PMID 20169186 DOI: 10.1371/Journal.Ppat.1000764 |
0.564 |
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| 2010 |
Beer S, Bellovin DI, Lee JS, Komatsubara K, Wang LS, Koh H, Börner K, Storm TA, Davis CR, Kay MA, Felsher DW, Grimm D. Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 161-70. PMID 19844192 DOI: 10.1038/Mt.2009.222 |
0.592 |
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| 2010 |
Börner K, Grimm D. Use of small RNAs for therapeutic gene silencing: Risk versus benefit Drug Discovery Today: Technologies. 7: e51-e57. DOI: 10.1016/J.Ddtec.2010.07.003 |
0.434 |
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| 2009 |
Grimm D. Small silencing RNAs: state-of-the-art. Advanced Drug Delivery Reviews. 61: 672-703. PMID 19427885 DOI: 10.1016/J.Addr.2009.05.002 |
0.431 |
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| 2008 |
Giering JC, Grimm D, Storm TA, Kay MA. Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1630-6. PMID 18665161 DOI: 10.1038/Mt.2008.144 |
0.78 |
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| 2008 |
Doege H, Grimm D, Falcon A, Tsang B, Storm TA, Xu H, Ortegon AM, Kazantzis M, Kay MA, Stahl A. Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. The Journal of Biological Chemistry. 283: 22186-92. PMID 18524776 DOI: 10.1074/Jbc.M803510200 |
0.51 |
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| 2008 |
Grimm D, Lee JS, Wang L, Desai T, Akache B, Storm TA, Kay MA. In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. Journal of Virology. 82: 5887-911. PMID 18400866 DOI: 10.1128/Jvi.00254-08 |
0.63 |
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| 2008 |
Streetz KL, Doyonnas R, Grimm D, Jenkins DD, Fuess S, Perryman S, Lin J, Trautwein C, Shizuru J, Blau H, Sylvester KG, Kay MA. Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells. Hepatology (Baltimore, Md.). 47: 706-18. PMID 18220289 DOI: 10.1002/Hep.22012 |
0.494 |
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| 2007 |
Grimm D, Kay MA. Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? The Journal of Clinical Investigation. 117: 3633-41. PMID 18060021 DOI: 10.1172/Jci34129 |
0.544 |
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| 2007 |
Grimm D, Kay MA. RNAi and gene therapy: a mutual attraction. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 473-81. PMID 18024667 DOI: 10.1182/Asheducation-2007.1.473 |
0.648 |
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| 2007 |
Paskowitz DM, Greenberg KP, Yasumura D, Grimm D, Yang H, Duncan JL, Kay MA, Lavail MM, Flannery JG, Vollrath D. Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium. Human Gene Therapy. 18: 871-80. PMID 17892416 DOI: 10.1089/Hum.2007.065 |
0.642 |
|
| 2007 |
Grimm D, Kay MA. Combinatorial RNAi: a winning strategy for the race against evolving targets? Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 878-88. PMID 17311009 DOI: 10.1038/Sj.Mt.6300116 |
0.639 |
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| 2007 |
Akache B, Grimm D, Shen X, Fuess S, Yant SR, Glazer DS, Park J, Kay MA. A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 330-9. PMID 17235311 DOI: 10.1038/Sj.Mt.6300053 |
0.695 |
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| 2006 |
Akache B, Grimm D, Pandey K, Yant SR, Xu H, Kay MA. The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9. Journal of Virology. 80: 9831-6. PMID 16973587 DOI: 10.1128/Jvi.00878-06 |
0.616 |
|
| 2006 |
Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. 441: 537-41. PMID 16724069 DOI: 10.1038/Nature04791 |
0.649 |
|
| 2006 |
Grimm D, Kay MA. Therapeutic short hairpin RNA expression in the liver: viral targets and vectors. Gene Therapy. 13: 563-75. PMID 16453009 DOI: 10.1038/Sj.Gt.3302727 |
0.591 |
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| 2006 |
Müller OJ, Leuchs B, Pleger ST, Grimm D, Franz WM, Katus HA, Kleinschmidt JA. Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors. Cardiovascular Research. 70: 70-8. PMID 16448634 DOI: 10.1016/J.Cardiores.2005.12.017 |
0.68 |
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| 2006 |
Grimm D, Pandey K, Nakai H, Storm TA, Kay MA. Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype. Journal of Virology. 80: 426-39. PMID 16352567 DOI: 10.1128/Jvi.80.1.426-439.2006 |
0.636 |
|
| 2006 |
Giering JC, Grimm D, Storm TA, Xu H, Kay MA. 796. Pol II-Driven shRNA as an Effective Hepatitis B Virus Therapeutic Molecular Therapy. 13: S308-S309. DOI: 10.1016/J.Ymthe.2006.08.885 |
0.772 |
|
| 2006 |
Grimm D, Lee JS, Storm TA, Kay MA. 742. Molecular Evolution of Adeno-Associated Viral (AAV) Vectors Via DNA Family Shuffling of Primate and Non-Primate Serotypes Molecular Therapy. 13: S287. DOI: 10.1016/J.Ymthe.2006.08.824 |
0.642 |
|
| 2006 |
Hebert ML, Grimm D, Storm TA, Kay MA. 489. Treatment for Hemophilia B Using Self- Complimentary AAV8 Vectors Molecular Therapy. 13: S189-S190. DOI: 10.1016/J.Ymthe.2006.08.559 |
0.655 |
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| 2006 |
Akache B, Fuess S, Grimm D, Kay MA. 103. A Screen for Host Cellular Proteins That Interact with Adeno-Associated Virus Capsid Proteins Reveals Proteins Involved in AAV8 Transduction Molecular Therapy. 13: S42-S43. DOI: 10.1016/J.Ymthe.2006.08.123 |
0.608 |
|
| 2006 |
Grimm D, Streetz KL, Storm TA, Jopling CL, Lee JS, Kay MA. 805. Fatality in Mice Due to Oversaturation of Cellular Micro/Short Hairpin RNA Pathways Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.1226 |
0.661 |
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| 2006 |
Grimm D, Lee JS, Streetz KL, Storm TA, Kay MA. 1066. A Novel Class of Miniature Stabilized Double-Stranded AAV (msdsAAV) Vectors for the In Vivo Expression of Short Hairpin RNAs Molecular Therapy. 13: S409. DOI: 10.1016/J.Ymthe.2006.08.1164 |
0.625 |
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| 2005 |
Riu E, Grimm D, Huang Z, Kay MA. Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo. Human Gene Therapy. 16: 558-70. PMID 15916481 DOI: 10.1089/Hum.2005.16.558 |
0.611 |
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| 2005 |
Grimm D, Pandey K, Kay MA. Adeno-associated virus vectors for short hairpin RNA expression. Methods in Enzymology. 392: 381-405. PMID 15644194 DOI: 10.1016/S0076-6879(04)92023-X |
0.669 |
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| 2005 |
Grimm D, Pandey K, Streetz KL, Kay MA. 857. A Versatile and Efficient Viral Vector Platform for Stable In Vivo Expression of Short Hairpin RNA Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.400 |
0.682 |
|
| 2005 |
Grimm D, Streetz KL, Pandey K, Storm TA, Kay MA. 87. Determinants of Toxicity Induced by In Vivo Expression of Short Hairpin RNA from AAV Vectors Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.065 |
0.687 |
|
| 2004 |
Grimm D, Streetz KL, Storm TA, Nakai H, McCaffrey AP, Huang Z, Salazar FH, Marion PL, Kay MA. 371. Complete Inhibition of Hepatitis B Virus Gene Expression In Vivo with Short Hairpin RNA Expressed from a Novel Double-Stranded, Bi-Cistronic Adeno-Associated Virus Pseudotype 8 Vector Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.918 |
0.659 |
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| 2004 |
Grimm D, Nakai H, Storm TA, Riu EP, Kay MA. 96. Transgene Expression from Recombinant AAV-8 Vectors in the Liver Occurs Independently of the Serotype Origin of the Viral Inverted Terminal Repeats Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.031 |
0.634 |
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| 2003 |
Grimm D, Kay MA. From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy. Current Gene Therapy. 3: 281-304. PMID 12871018 DOI: 10.2174/1566523034578285 |
0.642 |
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| 2003 |
Grimm D, Zhou S, Nakai H, Thomas CE, Storm TA, Fuess S, Matsushita T, Allen J, Surosky R, Lochrie M, Meuse L, McClelland A, Colosi P, Kay MA. Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy. Blood. 102: 2412-9. PMID 12791653 DOI: 10.1182/Blood-2003-02-0495 |
0.647 |
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| 2003 |
Grimm D, Kay MA, Kleinschmidt JA. Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 839-50. PMID 12788658 DOI: 10.1016/S1525-0016(03)00095-9 |
0.745 |
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| 2002 |
Grimm D. Production methods for gene transfer vectors based on adeno-associated virus serotypes. Methods (San Diego, Calif.). 28: 146-57. PMID 12413413 DOI: 10.1016/S1046-2023(02)00219-0 |
0.515 |
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| 2002 |
Rohr UP, Kronenwett R, Grimm D, Kleinschmidt J, Haas R. Primary human cells differ in their susceptibility to rAAV-2-mediated gene transfer and duration of reporter gene expression. Journal of Virological Methods. 105: 265-75. PMID 12270659 DOI: 10.1016/S0166-0934(02)00117-9 |
0.629 |
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| 2001 |
Jiang S, Altmann A, Grimm D, Kleinschmidt JA, Schilling T, Germann C, Haberkorn U. Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors. Cancer Gene Therapy. 8: 469-72. PMID 11498767 DOI: 10.1038/Sj.Cgt.7700327 |
0.635 |
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| 2001 |
King JA, Dubielzig R, Grimm D, Kleinschmidt JA. DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids. The Embo Journal. 20: 3282-91. PMID 11406604 DOI: 10.1093/Emboj/20.12.3282 |
0.604 |
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| 2000 |
Kunke D, Grimm D, Denger S, Kreuzer J, Delius H, Komitowski D, Kleinschmidt JA. Preclinical study on gene therapy of cervical carcinoma using adeno-associated virus vectors. Cancer Gene Therapy. 7: 766-77. PMID 10830724 DOI: 10.1038/Sj.Cgt.7700178 |
0.638 |
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| 1999 |
Grimm D, Kleinschmidt JA. Progress in adeno-associated virus type 2 vector production: promises and prospects for clinical use. Human Gene Therapy. 10: 2445-50. PMID 10543610 DOI: 10.1089/10430349950016799 |
0.683 |
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| 1999 |
Grimm D, Kern A, Pawlita M, Ferrari F, Samulski R, Kleinschmidt J. Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2. Gene Therapy. 6: 1322-30. PMID 10455443 DOI: 10.1038/Sj.Gt.3300946 |
0.621 |
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| 1999 |
Hörster A, Teichmann B, Hormes R, Grimm D, Kleinschmidt J, Sczakiel G. Recombinant AAV-2 harboring gfp-antisense/ribozyme fusion sequences monitor transduction, gene expression, and show anti-HIV-1 efficacy. Gene Therapy. 6: 1231-8. PMID 10455431 DOI: 10.1038/Sj.Gt.3300955 |
0.664 |
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| 1999 |
Hermens WT, ter Brake O, Dijkhuizen PA, Sonnemans MA, Grimm D, Kleinschmidt JA, Verhaagen J. Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system. Human Gene Therapy. 10: 1885-91. PMID 10446928 DOI: 10.1089/10430349950017563 |
0.673 |
|
| 1998 |
Grimm D, Kern A, Rittner K, Kleinschmidt JA. Novel tools for production and purification of recombinant adenoassociated virus vectors. Human Gene Therapy. 9: 2745-60. PMID 9874273 DOI: 10.1089/Hum.1998.9.18-2745 |
0.685 |
|
| 1997 |
Weger S, Wistuba A, Grimm D, Kleinschmidt JA. Control of adeno-associated virus type 2 cap gene expression: relative influence of helper virus, terminal repeats, and Rep proteins. Journal of Virology. 71: 8437-47. PMID 9343200 DOI: 10.1128/Jvi.71.11.8437-8447.1997 |
0.672 |
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| 1997 |
Wistuba A, Kern A, Weger S, Grimm D, Kleinschmidt JA. Subcellular compartmentalization of adeno-associated virus type 2 assembly. Journal of Virology. 71: 1341-52. PMID 8995658 DOI: 10.1128/Jvi.71.2.1341-1352.1997 |
0.617 |
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