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Vern L. Schramm, Ph.D. - Publications

Affiliations: 
Biochemistry Albert Einstein College of Medicine, New York, New York, United States 
Area:
enzymatic mechanisms and transition state structure
Website:
http://www.einstein.yu.edu/faculty/7856/vern-schramm/
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Year Citation  Score
2025 Ghosh AK, Groom DP, Schramm VL. Transition State Analysis of SAMHD1 from Primary O, P, and Solvent Kinetic Isotope Effects. Journal of the American Chemical Society. 147: 8852-8863. PMID 40014869 DOI: 10.1021/jacs.5c00521  0.409
2025 Wagner AG, Lang TBD, Ledingham ET, Ghosh A, Brooks D, Eskandari R, Suthagar K, Almo SC, Lamiable-Oulaidi F, Tyler PC, Schramm VL. Transition State Analogs of Human DNPH1 Reveal Two Electrophile Migration Mechanisms. Journal of Medicinal Chemistry. PMID 39818772 DOI: 10.1021/acs.jmedchem.4c02778  0.824
2023 Minnow YVT, Schramm VL, Almo SC, Ghosh A. Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity. Biochemistry. 62: 3116-3125. PMID 37812583 DOI: 10.1021/acs.biochem.3c00264  0.442
2023 Brown M, Schramm VL. Decreased Transition-State Analogue Affinity in Isotopically Heavy MTAN with Increased Catalysis. Biochemistry. PMID 37788145 DOI: 10.1021/acs.biochem.3c00434  0.42
2023 Mahmoodi N, Minnow YVT, Harijan RK, Bedard GT, Schramm VL. Cell-Effective Transition-State Analogue of Phenylethanolamine -Methyltransferase. Biochemistry. PMID 37467463 DOI: 10.1021/acs.biochem.3c00103  0.37
2023 Brown M, Tyler PC, Schramm VL. Residence Times for Femtomolar and Picomolar Inhibitors of MTANs. Biochemistry. PMID 37204861 DOI: 10.1021/acs.biochem.3c00145  0.445
2023 Wagner AG, Eskandari R, Schramm VL. An enzyme-coupled microplate assay for activity and inhibition of hmdUMP hydrolysis by DNPH1. Analytical Biochemistry. 672: 115171. PMID 37142196 DOI: 10.1016/j.ab.2023.115171  0.788
2022 V T Minnow Y, Suthagar K, Clinch K, Ducati RG, Ghosh A, Buckler JN, Harijan RK, Cahill SM, Tyler PC, Schramm VL. Inhibition and Mechanism of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase. Acs Chemical Biology. PMID 36413975 DOI: 10.1021/acschembio.2c00546  0.412
2022 Glockzin K, Kostomiris D, Minnow YVT, Suthagar K, Clinch K, Gai S, Buckler JN, Schramm VL, Tyler PC, Meek TD, Katzfuss A. Kinetic Characterization and Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferases. Biochemistry. 61: 2088-2105. PMID 36193631 DOI: 10.1021/acs.biochem.2c00312  0.324
2022 Paparella AS, Cahill SM, Aboulache BL, Schramm VL. TcdB Toxin Glucosylates Rho GTPase by an S Mechanism and Ion Pair Transition State. Acs Chemical Biology. 17: 2507-2518. PMID 36038138 DOI: 10.1021/acschembio.2c00408  0.825
2022 Lamiable-Oulaidi F, Harijan RK, Shaffer KJ, Crump DR, Sun Y, Du Q, Gulab SA, Khan AA, Luxenburger A, Woolhouse AD, Sidoli S, Tyler PC, Schramm VL. Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1. Journal of Medicinal Chemistry. 65: 5462-5494. PMID 35324190 DOI: 10.1021/acs.jmedchem.1c01869  0.329
2021 Paparella AS, Aboulache BL, Harijan RK, Potts KS, Tyler PC, Schramm VL. Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues. Nature Communications. 12: 6285. PMID 34725358 DOI: 10.1038/s41467-021-26580-6  0.836
2021 Ghosh A, Niland CN, Cahill SM, Karadkhelkar NM, Schramm VL. Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 Å Resolution. Journal of the American Chemical Society. PMID 34668717 DOI: 10.1021/jacs.1c09328  0.433
2021 Brown M, Zoi I, Antoniou D, Namanja-Magliano HA, Schwartz SD, Schramm VL. Inverse heavy enzyme isotope effects in methylthioadenosine nucleosidases. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34580228 DOI: 10.1073/pnas.2109118118  0.411
2021 Ghosh AK, Schramm VL. Protein Mass-Modulated Effects in Alkaline Phosphatase. Biochemistry. PMID 33410323 DOI: 10.1021/acs.biochem.0c00917  0.326
2020 Mahmoodi N, Harijan RK, Schramm VL. Transition-State Analogues of Phenylethanolamine N-methyltransferase. Journal of the American Chemical Society. PMID 32702980 DOI: 10.1021/Jacs.0C05446  0.486
2020 Li XP, Harijan RK, Kahn JN, Schramm VL, Tumer NE. Small molecule inhibitors targeting the interaction of ricin toxin A subunit with ribosomes. Acs Infectious Diseases. PMID 32428396 DOI: 10.1021/Acsinfecdis.0C00127  0.348
2020 Zhang D, Burdette B, Wang Z, Karn K, Li HY, Schramm VL, Tyler PC, Evans GB, Wang S. Transition state analogs enhanced by fragment-based structural analysis: Bacterial methylthioadenosine nucleosidases. Biochemistry. PMID 32022543 DOI: 10.1021/Acs.Biochem.9B01092  0.48
2019 Joshi S, Fedoseyenko D, Mahanta N, Ducati RG, Feng M, Schramm VL, Begley TP. Antibacterial Strategy against : Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis. Acs Medicinal Chemistry Letters. 10: 363-366. PMID 30891141 DOI: 10.1021/Acsmedchemlett.8B00649  0.363
2019 Harijan RK, Hoff O, Ducati RG, Firestone RS, Hirsch BM, Evans GB, Schramm VL, Tyler PC. "Selective inhibitors of H. pylori methylthioadenosine nucleosidase and human methylthioadenosine phosphorylase". Journal of Medicinal Chemistry. PMID 30860833 DOI: 10.1021/Acs.Jmedchem.8B01642  0.502
2018 Evans GB, Schramm VL, Tyler PC. The transition to magic bullets - transition state analogue drug design. Medchemcomm. 9: 1983-1993. PMID 30627387 DOI: 10.1039/C8Md00372F  0.409
2018 Ducati RG, Harijan RK, Cameron SA, Tyler PC, Evans GB, Schramm VL. Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. Acs Chemical Biology. PMID 30339406 DOI: 10.1021/Acschembio.8B00781  0.541
2018 Schramm VL. Enzymatic Transition States and Drug Design. Chemical Reviews. PMID 30335982 DOI: 10.1021/Acs.Chemrev.8B00369  0.527
2018 Harijan RK, Zoi I, Antoniou D, Schwartz SD, Schramm VL. Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels. Proceedings of the National Academy of Sciences of the United States of America. PMID 29915028 DOI: 10.1073/Pnas.1805416115  0.418
2018 Schramm VL, Schwartz SD. Promoting vibrations and the function of enzymes. Emerging theoretical and experimental convergence. Biochemistry. PMID 29608286 DOI: 10.1021/Acs.Biochem.8B00201  0.456
2018 Ducati RG, Namanja-Magliano HA, Harijan RK, Fajardo JE, Fiser A, Daily JP, Schramm VL. Genetic resistance to purine nucleoside phosphorylase inhibition in. Proceedings of the National Academy of Sciences of the United States of America. PMID 29440412 DOI: 10.1073/Pnas.1525670115  0.394
2017 Harris LD, Harijan RK, Ducati RG, Evans GB, Hirsch BM, Schramm VL. Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase. Acs Chemical Biology. PMID 29178779 DOI: 10.1021/acschembio.7b00601  0.427
2017 Evans GB, Tyler PC, Schramm VL. Immucillins in Infectious Diseases. Acs Infectious Diseases. PMID 29151351 DOI: 10.1021/acsinfecdis.7b00172  0.353
2017 Ducati RG, Firestone RS, Schramm VL. Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum. Biochemistry. PMID 29131588 DOI: 10.1021/Acs.Biochem.7B01027  0.567
2017 Stratton CF, Poulin MB, Schramm VL. Binding Isotope Effects for Interrogating Enzyme-Substrate Interactions. Methods in Enzymology. 596: 1-21. PMID 28911767 DOI: 10.1016/bs.mie.2017.07.019  0.352
2017 Firestone RS, Schramm VL. "Transition-State Structure for Human MAT2A from Isotope Effects". Journal of the American Chemical Society. PMID 28880543 DOI: 10.1021/jacs.7b05803  0.473
2017 Moggré GJ, Poulin MB, Tyler PC, Schramm VL, Parker EJ. Transition state analysis of adenosine triphosphate phosphoribosyltransferase. Acs Chemical Biology. PMID 28872824 DOI: 10.1021/Acschembio.7B00484  0.428
2017 Namanja-Magliano HA, Evans GB, Harijan R, Tyler PC, Schramm VL. "Transition state analogue inhibitors of 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase from Mycobacterium tuberculosis". Biochemistry. PMID 28836767 DOI: 10.1021/Acs.Biochem.7B00576  0.539
2017 Gebre ST, Cameron SA, Li L, Babu YS, Schramm VL. Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase. The Journal of Biological Chemistry. PMID 28794158 DOI: 10.1074/Jbc.M117.801779  0.46
2017 Harijan RK, Zoi I, Antoniou D, Schwartz SD, Schramm VL. Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28584087 DOI: 10.1073/Pnas.1704786114  0.395
2016 Firestone RS, Cameron SA, Karp JM, Arcus VL, Schramm VL. Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase. Acs Chemical Biology. PMID 28026167 DOI: 10.1021/Acschembio.6B00885  0.524
2016 Stratton CF, Poulin MB, Du Q, Schramm VL. Kinetic isotope effects and transition state structure for human phenylethanolamine N-methyltransferase. Acs Chemical Biology. PMID 27997103 DOI: 10.1021/Acschembio.6B00922  0.535
2016 Mason JM, Yuan H, Evans GB, Tyler PC, Du Q, Schramm VL. Oligonucleotide transition state analogues of saporin L3. European Journal of Medicinal Chemistry. PMID 27823883 DOI: 10.1016/j.ejmech.2016.10.059  0.331
2016 Firestone RS, Cameron SA, Tyler PC, Ducati RG, Spitz AZ, Schramm VL. "Continuous Fluorescence Assays for Reactions Involving Adenine". Analytical Chemistry. PMID 27779859 DOI: 10.1021/acs.analchem.6b03621  0.37
2016 Wang Z, Chang EP, Schramm VL. "Triple Isotope Effects Support Concerted Hydride and Proton Transfer and Promoting Vibrations in Human Heart Lactate Dehydrogenase". Journal of the American Chemical Society. PMID 27766841 DOI: 10.1021/Jacs.6B09049  0.45
2016 Poulin MB, Schneck JL, Matico RE, Hou W, McDevitt PJ, Holbert M, Schramm VL. "Nucleosome binding alters the substrate bonding environment of Histone H3 Lysine 36 Methyltransferase NSD2". Journal of the American Chemical Society. PMID 27183271 DOI: 10.1021/Jacs.6B01612  0.339
2016 Namanja-Magliano HA, Stratton CF, Schramm VL. "Transition state structure and inhibition of Rv0091, a 5-deoxyadenosine / 5-methylthioadenosine nucleosidase from Mycobacterium tuberculosis." Acs Chemical Biology. PMID 27019223 DOI: 10.1021/Acschembio.6B00144  0.578
2016 Du Q, Wang Z, Schramm VL. Human DNMT1 transition state structure. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929335 DOI: 10.1073/Pnas.1522491113  0.36
2016 Yuan H, Stratton CF, Schramm VL. Transition state structure of RNA depurination by saporin L3. Acs Chemical Biology. PMID 26886255 DOI: 10.1021/acschembio.5b01069  0.404
2016 Poulin MB, Schneck JL, Matico RE, McDevitt PJ, Huddleston MJ, Hou W, Johnson NW, Thrall SH, Meek TD, Schramm VL. Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787850 DOI: 10.1073/pnas.1521036113  0.445
2015 Wang Z, Antoniou D, Schwartz SD, Schramm VL. "Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects and Heavy Enzyme Studies". Biochemistry. PMID 26652185 DOI: 10.1021/Acs.Biochem.5B01241  0.326
2015 Suarez J, Schramm VL. Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase. Proceedings of the National Academy of Sciences of the United States of America. 112: 11247-51. PMID 26305965 DOI: 10.1073/Pnas.1513956112  0.438
2015 Evans GB, Schramm VL, Tyler PC. The Immucillins: Design, Synthesis and Application of Transition State Analogues. Current Medicinal Chemistry. PMID 26295462 DOI: 10.2174/0929867322666150821100851  0.51
2015 Stratton CF, Namanja-Magliano HA, Cameron SA, Schramm VL. Binding Isotope Effects for para-Aminobenzoic Acid with Dihydropteroate Synthase from Staphylococcus aureus and Plasmodium falciparum. Acs Chemical Biology. 10: 2182-6. PMID 26288086 DOI: 10.1021/Acschembio.5B00490  0.352
2015 Evans GB, Cameron SA, Luxenburger A, Guan R, Suarez J, Thomas K, Schramm VL, Tyler PC. Tight binding enantiomers of pre-clinical drug candidates. Bioorganic & Medicinal Chemistry. 23: 5326-33. PMID 26260335 DOI: 10.1016/J.Bmc.2015.07.059  0.423
2015 Poulin MB, Du Q, Schramm VL. Chemoenzymatic Synthesis of (36)S Isotopologues of Methionine and S-Adenosyl-L-methionine. The Journal of Organic Chemistry. 80: 5344-7. PMID 25884979 DOI: 10.1021/Acs.Joc.5B00608  0.359
2015 Schramm VL. Transition States and transition state analogue interactions with enzymes. Accounts of Chemical Research. 48: 1032-9. PMID 25848811 DOI: 10.1021/Acs.Accounts.5B00002  0.563
2015 Thomas K, Cameron SA, Almo SC, Burgos ES, Gulab SA, Schramm VL. Active site and remote contributions to catalysis in methylthioadenosine nucleosidases. Biochemistry. 54: 2520-9. PMID 25806409 DOI: 10.1021/Bi501487W  0.443
2015 Zoi I, Motley MW, Antoniou D, Schramm VL, Schwartz SD. Enzyme homologues have distinct reaction paths through their transition states. The Journal of Physical Chemistry. B. 119: 3662-8. PMID 25650981 DOI: 10.1021/Jp511983H  0.482
2015 Evans GB, Gainsford GJ, Schramm VL, Tyler PC. The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase Tetrahedron Letters. 56: 406-409. DOI: 10.1016/j.tetlet.2014.11.113  0.432
2015 Evans GB, Schramm VL, Tyler PC. The immucillins: Design, synthesis and application of transition-state analogues Current Medicinal Chemistry. 22: 3897-3909.  0.353
2014 Barta ML, Thomas K, Yuan H, Lovell S, Battaile KP, Schramm VL, Hefty PS. Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway. The Journal of Biological Chemistry. 289: 32214-29. PMID 25253688 DOI: 10.1074/Jbc.M114.594325  0.322
2014 Hirsch BM, Burgos ES, Schramm VL. Transition-state analysis of 2-O-acetyl-ADP-ribose hydrolysis by human macrodomain 1. Acs Chemical Biology. 9: 2255-62. PMID 25051211 DOI: 10.1021/Cb500485W  0.458
2014 Wang Z, Singh P, Czekster CM, Kohen A, Schramm VL. Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: beyond promoting vibrations. Journal of the American Chemical Society. 136: 8333-41. PMID 24820793 DOI: 10.1021/Ja501936D  0.639
2014 Donaldson TM, Cassera MB, Ho MC, Zhan C, Merino EF, Evans GB, Tyler PC, Almo SC, Schramm VL, Kim K. Inhibition and structure of Toxoplasma gondii purine nucleoside phosphorylase. Eukaryotic Cell. 13: 572-9. PMID 24585883 DOI: 10.1128/Ec.00308-13  0.556
2014 Wang S, Thomas K, Schramm VL. Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase. Biochemistry. 53: 1527-35. PMID 24502544 DOI: 10.1021/Bi401589N  0.424
2013 Zhang Y, Evans GB, Clinch K, Crump DR, Harris LD, Fröhlich RF, Tyler PC, Hazleton KZ, Cassera MB, Schramm VL. Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. The Journal of Biological Chemistry. 288: 34746-54. PMID 24158442 DOI: 10.1074/Jbc.M113.521955  0.58
2013 Guan R, Tyler PC, Evans GB, Schramm VL. Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase. Biochemistry. 52: 8313-22. PMID 24148083 DOI: 10.1021/Bi401188W  0.507
2013 Vetticatt MJ, Itin B, Evans GB, Schramm VL. Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR. Proceedings of the National Academy of Sciences of the United States of America. 110: 15991-6. PMID 24043827 DOI: 10.1073/Pnas.1313657110  0.814
2013 Motley MW, Schramm VL, Schwartz SD. Conformational freedom in tight binding enzymatic transition-state analogues. The Journal of Physical Chemistry. B. 117: 9591-7. PMID 23895500 DOI: 10.1021/Jp4030443  0.447
2013 Ducati RG, Namanja-Magliano HA, Schramm VL. Transition-state inhibitors of purine salvage and other prospective enzyme targets in malaria. Future Medicinal Chemistry. 5: 1341-60. PMID 23859211 DOI: 10.4155/Fmc.13.51  0.538
2013 Clinch K, Crump DR, Evans GB, Hazleton KZ, Mason JM, Schramm VL, Tyler PC. Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic & Medicinal Chemistry. 21: 5629-46. PMID 23810424 DOI: 10.1016/J.Bmc.2013.02.016  0.37
2013 Haapalainen AM, Thomas K, Tyler PC, Evans GB, Almo SC, Schramm VL. Salmonella enterica MTAN at 1.36 Ã… resolution: a structure-based design of tailored transition state analogs. Structure (London, England : 1993). 21: 963-74. PMID 23685211 DOI: 10.1016/J.Str.2013.04.009  0.512
2013 Suarez J, Haapalainen AM, Cahill SM, Ho MC, Yan F, Almo SC, Schramm VL. Catalytic site conformations in human PNP by 19F-NMR and crystallography. Chemistry & Biology. 20: 212-22. PMID 23438750 DOI: 10.1016/J.Chembiol.2013.01.009  0.434
2013 Burgos ES, Vetticatt MJ, Schramm VL. Recycling nicotinamide. The transition-state structure of human nicotinamide phosphoribosyltransferase. Journal of the American Chemical Society. 135: 3485-93. PMID 23373462 DOI: 10.1021/Ja310180C  0.769
2013 Schramm VL. Transition States, analogues, and drug development. Acs Chemical Biology. 8: 71-81. PMID 23259601 DOI: 10.1021/Cb300631K  0.562
2012 Antoniou D, Ge X, Schramm VL, Schwartz SD. Mass Modulation of Protein Dynamics Associated with Barrier Crossing in Purine Nucleoside Phosphorylase. The Journal of Physical Chemistry Letters. 3: 3538-3544. PMID 24496053 DOI: 10.1021/Jz301670S  0.477
2012 Guan R, Ho MC, Fröhlich RF, Tyler PC, Almo SC, Schramm VL. Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa. Biochemistry. 51: 9094-103. PMID 23050701 DOI: 10.1021/Bi301062Y  0.469
2012 Thomas K, Haapalainen AM, Burgos ES, Evans GB, Tyler PC, Gulab S, Guan R, Schramm VL. Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy. Biochemistry. 51: 7541-50. PMID 22931458 DOI: 10.1021/Bi3009938  0.407
2012 Wang S, Haapalainen AM, Yan F, Du Q, Tyler PC, Evans GB, Rinaldo-Matthis A, Brown RL, Norris GE, Almo SC, Schramm VL. A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori. Biochemistry. 51: 6892-4. PMID 22891633 DOI: 10.1021/Bi3009664  0.464
2012 Silva RG, Kipp DR, Schramm VL. Constrained bonding environment in the Michaelis complex of Trypanosoma cruzi uridine phosphorylase. Biochemistry. 51: 6715-7. PMID 22870934 DOI: 10.1021/Bi300914Q  0.479
2012 Clinch K, Evans GB, Fröhlich RF, Gulab SA, Gutierrez JA, Mason JM, Schramm VL, Tyler PC, Woolhouse AD. Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics. Bioorganic & Medicinal Chemistry. 20: 5181-7. PMID 22854195 DOI: 10.1016/j.bmc.2012.07.006  0.325
2012 Kipp DR, Hirschi JS, Wakata A, Goldstein H, Schramm VL. Transition states of native and drug-resistant HIV-1 protease are the same. Proceedings of the National Academy of Sciences of the United States of America. 109: 6543-8. PMID 22493227 DOI: 10.1073/Pnas.1202808109  0.45
2012 Burgos ES, Gulab SA, Cassera MB, Schramm VL. Luciferase-based assay for adenosine: application to S-adenosyl-L-homocysteine hydrolase. Analytical Chemistry. 84: 3593-8. PMID 22416759 DOI: 10.1021/Ac203297Z  0.353
2012 Wang S, Lim J, Thomas K, Yan F, Angeletti RH, Schramm VL. A complex of methylthioadenosine/S-adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry. Journal of the American Chemical Society. 134: 1468-70. PMID 22239413 DOI: 10.1021/Ja211176Q  0.462
2011 Cassera MB, Hazleton KZ, Merino EF, Obaldia N, Ho MC, Murkin AS, DePinto R, Gutierrez JA, Almo SC, Evans GB, Babu YS, Schramm VL. Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. Plos One. 6: e26916. PMID 22096507 DOI: 10.1371/journal.pone.0026916  0.706
2011 Silva RG, Murkin AS, Schramm VL. Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme. Proceedings of the National Academy of Sciences of the United States of America. 108: 18661-5. PMID 22065757 DOI: 10.1073/Pnas.1114900108  0.754
2011 Kipp DR, Silva RG, Schramm VL. Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease. Journal of the American Chemical Society. 133: 19358-61. PMID 22059645 DOI: 10.1021/ja209391n  0.315
2011 Guan R, Ho MC, Brenowitz M, Tyler PC, Evans GB, Almo SC, Schramm VL. Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase. Biochemistry. 50: 10408-17. PMID 21985704 DOI: 10.1021/Bi201321X  0.442
2011 Silva RG, Schramm VL. Uridine phosphorylase from Trypanosoma cruzi: kinetic and chemical mechanisms. Biochemistry. 50: 9158-66. PMID 21932786 DOI: 10.1021/Bi2013382  0.497
2011 Schramm VL. Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes. Annual Review of Biochemistry. 80: 703-32. PMID 21675920 DOI: 10.1146/Annurev-Biochem-061809-100742  0.564
2011 Cassera MB, Zhang Y, Hazleton KZ, Schramm VL. Purine and pyrimidine pathways as targets in Plasmodium falciparum. Current Topics in Medicinal Chemistry. 11: 2103-15. PMID 21619511 DOI: 10.2174/156802611796575948  0.394
2011 Silva RG, Vetticatt MJ, Merino EF, Cassera MB, Schramm VL. Transition-state analysis of Trypanosoma cruzi uridine phosphorylase-catalyzed arsenolysis of uridine. Journal of the American Chemical Society. 133: 9923-31. PMID 21599004 DOI: 10.1021/Ja2031294  0.802
2011 Hemeon I, Gutierrez JA, Ho MC, Schramm VL. Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay. Analytical Chemistry. 83: 4996-5004. PMID 21545095 DOI: 10.1021/Ac200816M  0.341
2011 Zhang Y, Schramm VL. Ground-state destabilization in orotate phosphoribosyltransferases by binding isotope effects. Biochemistry. 50: 4813-8. PMID 21526795 DOI: 10.1021/Bi200638X  0.511
2011 Silva RG, Hirschi JS, Ghanem M, Murkin AS, Schramm VL. Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase. Biochemistry. 50: 2701-9. PMID 21348499 DOI: 10.1021/Bi200279S  0.786
2011 Schwartz PA, Vetticatt MJ, Schramm VL. Transition state analysis of the arsenolytic depyrimidination of thymidine by human thymidine phosphorylase. Biochemistry. 50: 1412-20. PMID 21222488 DOI: 10.1021/Bi101900B  0.845
2011 Guan R, Ho MC, Almo SC, Schramm VL. Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing. Biochemistry. 50: 1247-54. PMID 21197954 DOI: 10.1021/Bi101642D  0.496
2011 Basu I, Locker J, Cassera MB, Belbin TJ, Merino EF, Dong X, Hemeon I, Evans GB, Guha C, Schramm VL. Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase. The Journal of Biological Chemistry. 286: 4902-11. PMID 21135097 DOI: 10.1074/Jbc.M110.198374  0.301
2010 Zhang Y, Deng H, Schramm VL. Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase. Journal of the American Chemical Society. 132: 17023-31. PMID 21067187 DOI: 10.1021/Ja107806J  0.487
2010 Hirschi JS, Arora K, Brooks CL, Schramm VL. Conformational dynamics in human purine nucleoside phosphorylase with reactants and transition-state analogues. The Journal of Physical Chemistry. B. 114: 16263-72. PMID 20936808 DOI: 10.1021/Jp108056S  0.356
2010 Schwartz PA, Vetticatt MJ, Schramm VL. Transition state analysis of thymidine hydrolysis by human thymidine phosphorylase. Journal of the American Chemical Society. 132: 13425-33. PMID 20804144 DOI: 10.1021/Ja105041J  0.823
2010 Longshaw AI, Adanitsch F, Gutierrez JA, Evans GB, Tyler PC, Schramm VL. Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase. Journal of Medicinal Chemistry. 53: 6730-46. PMID 20718423 DOI: 10.1021/Jm100898V  0.449
2010 Zhang Y, Schramm VL. Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases. Journal of the American Chemical Society. 132: 8787-94. PMID 20527751 DOI: 10.1021/Ja102849W  0.613
2010 Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, ... ... Schramm VL, et al. Climate change and the integrity of science. Science (New York, N.Y.). 328: 689-90. PMID 20448167 DOI: 10.1126/Science.328.5979.689  0.397
2010 Ho MC, Shi W, Rinaldo-Matthis A, Tyler PC, Evans GB, Clinch K, Almo SC, Schramm VL. Four generations of transition-state analogues for human purine nucleoside phosphorylase. Proceedings of the National Academy of Sciences of the United States of America. 107: 4805-12. PMID 20212140 DOI: 10.1073/Pnas.0913439107  0.494
2010 Deng H, Callender R, Schramm VL, Grubmeyer C. Pyrophosphate activation in hypoxanthine--guanine phosphoribosyltransferase with transition state analogue. Biochemistry. 49: 2705-14. PMID 20170081 DOI: 10.1021/Bi100012U  0.418
2010 Edwards AA, Tipton JD, Brenowitz MD, Emmett MR, Marshall AG, Evans GB, Tyler PC, Schramm VL. Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues. Biochemistry. 49: 2058-67. PMID 20108972 DOI: 10.1021/Bi902041J  0.793
2010 Evans GB, Furneaux RH, Gainsford GJ, Schramm VL, Tyler PC. ChemInform Abstract: Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200031222  0.419
2010 BAGDASSARIAN CK, SCHRAMM VL, SCHWARTZ SD. ChemInform Abstract: Molecular Electrostatic Potential Analysis for Enzymatic Substrates, Competitive Inhibitors, and Transition-State Inhibitors Cheminform. 28: no-no. DOI: 10.1002/CHIN.199703286  0.397
2010 HORENSTEIN BA, ZABINSKI RF, SCHRAMM VL. ChemInform Abstract: A New Class of C-Nucleoside Analogues. 1-(S)-Aryl-1,4-dideoxy-1,4- imino-D-ribitols, Transition State Analogue Inhibitors of Nucleoside Hydrolase. Cheminform. 25: no-no. DOI: 10.1002/CHIN.199418230  0.357
2009 Ho MC, Sturm MB, Almo SC, Schramm VL. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proceedings of the National Academy of Sciences of the United States of America. 106: 20276-81. PMID 19920175 DOI: 10.1073/Pnas.0911606106  0.552
2009 Ghanem M, Murkin AS, Schramm VL. Ribocation transition state capture and rebound in human purine nucleoside phosphorylase. Chemistry & Biology. 16: 971-9. PMID 19778725 DOI: 10.1016/J.Chembiol.2009.07.012  0.781
2009 Sturm MB, Tyler PC, Evans GB, Schramm VL. Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein. Biochemistry. 48: 9941-8. PMID 19764816 DOI: 10.1021/bi901425h  0.373
2009 Schramm VL. Transition States. The Journal of Biological Chemistry. 284: 32201-8. PMID 19758992 DOI: 10.1074/jbc.X109.060111  0.42
2009 Ho MC, Cassera MB, Madrid DC, Ting LM, Tyler PC, Kim K, Almo SC, Schramm VL. Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. Biochemistry. 48: 9618-26. PMID 19728741 DOI: 10.1021/Bi9012484  0.319
2009 Burgos ES, Ho MC, Almo SC, Schramm VL. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proceedings of the National Academy of Sciences of the United States of America. 106: 13748-53. PMID 19666527 DOI: 10.1073/Pnas.0903898106  0.386
2009 Schwartz SD, Schramm VL. Enzymatic transition states and dynamic motion in barrier crossing. Nature Chemical Biology. 5: 551-8. PMID 19620996 DOI: 10.1038/Nchembio.202  0.474
2009 Edwards AA, Mason JM, Clinch K, Tyler PC, Evans GB, Schramm VL. Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase. Biochemistry. 48: 5226-38. PMID 19425594 DOI: 10.1021/Bi9005896  0.466
2009 Zhang Y, Luo M, Schramm VL. Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases. Journal of the American Chemical Society. 131: 4685-94. PMID 19292447 DOI: 10.1021/Ja808346Y  0.604
2009 Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL. Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. Nature Chemical Biology. 5: 251-7. PMID 19270684 DOI: 10.1038/Nchembio.153  0.431
2009 Ghanem M, Zhadin N, Callender R, Schramm VL. Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics. Biochemistry. 48: 3658-68. PMID 19191546 DOI: 10.1021/Bi802339C  0.391
2009 Clinch K, Evans GB, Fröhlich RF, Furneaux RH, Kelly PM, Legentil L, Murkin AS, Li L, Schramm VL, Tyler PC, Woolhouse AD. Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. Journal of Medicinal Chemistry. 52: 1126-43. PMID 19170524 DOI: 10.1021/Jm801421Q  0.717
2008 Saen-Oon S, Schramm VL, Schwartz SD. Transition Path Sampling Study of the Reaction Catalyzed by Purine Nucleoside Phosphorylase. Zeitschrift Fur Physikalische Chemie (Frankfurt Am Main, Germany). 222: 1359-1374. PMID 20664707 DOI: 10.1524/Zpch.2008.5395  0.456
2008 Madrid DC, Ting LM, Waller KL, Schramm VL, Kim K. Plasmodium falciparum purine nucleoside phosphorylase is critical for viability of malaria parasites. The Journal of Biological Chemistry. 283: 35899-907. PMID 18957439 DOI: 10.1074/Jbc.M807218200  0.365
2008 Saen-Oon S, Quaytman-Machleder S, Schramm VL, Schwartz SD. Atomic detail of chemical transformation at the transition state of an enzymatic reaction. Proceedings of the National Academy of Sciences of the United States of America. 105: 16543-8. PMID 18946041 DOI: 10.1073/Pnas.0808413105  0.421
2008 Burgos ES, Schramm VL. Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase. Biochemistry. 47: 11086-96. PMID 18823127 DOI: 10.1021/Bi801198M  0.366
2008 Mason JM, Murkin AS, Li L, Schramm VL, Gainsford GJ, Skelton BW. A beta-fluoroamine inhibitor of purine nucleoside phosphorylase. Journal of Medicinal Chemistry. 51: 5880-4. PMID 18800772 DOI: 10.1021/Jm800792B  0.691
2008 Murkin AS, Clinch K, Mason JM, Tyler PC, Schramm VL. Immucillins in custom catalytic-site cavities. Bioorganic & Medicinal Chemistry Letters. 18: 5900-3. PMID 18778937 DOI: 10.1016/J.Bmcl.2008.08.047  0.747
2008 Schramm VL, Gutierrez JA, Cordovano G, Basu I, Guha C, Belbin TJ, Evans GB, Tyler PC, Furneaux RH. Transition state analogues in quorum sensing and SAM recycling. Nucleic Acids Symposium Series (2004). 75-6. PMID 18776260 DOI: 10.1093/nass/nrn038  0.47
2008 Luo M, Schramm VL. Ribosyl geometry in the transition state of Streptococcus pneumoniae methylthioadenosine nucleosidase from the 3'-(2)H kinetic isotope effect. Journal of the American Chemical Society. 130: 11617-9. PMID 18693725 DOI: 10.1021/Ja804578M  0.518
2008 Li L, Luo M, Ghanem M, Taylor EA, Schramm VL. Second-sphere amino acids contribute to transition-state structure in bovine purine nucleoside phosphorylase. Biochemistry. 47: 2577-83. PMID 18281958 DOI: 10.1021/Bi7021365  0.804
2008 Luo M, Li L, Schramm VL. Remote mutations alter transition-state structure of human purine nucleoside phosphorylase. Biochemistry. 47: 2565-76. PMID 18281957 DOI: 10.1021/Bi702133X  0.516
2008 Ghanem M, Li L, Wing C, Schramm VL. Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase. Biochemistry. 47: 2559-64. PMID 18281956 DOI: 10.1021/Bi702132E  0.414
2008 Ghanem M, Saen-oon S, Zhadin N, Wing C, Cahill SM, Schwartz SD, Callender R, Schramm VL. Tryptophan-free human PNP reveals catalytic site interactions. Biochemistry. 47: 3202-15. PMID 18269249 DOI: 10.1021/Bi702491D  0.317
2008 Evans GB, Furneaux RH, Greatrex B, Murkin AS, Schramm VL, Tyler PC. Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. Journal of Medicinal Chemistry. 51: 948-56. PMID 18251493 DOI: 10.1021/Jm701265N  0.763
2008 Luo M, Schramm VL. Transition state structure of E. coli tRNA-specific adenosine deaminase. Journal of the American Chemical Society. 130: 2649-55. PMID 18251477 DOI: 10.1021/Ja078008X  0.546
2008 Saen-Oon S, Ghanem M, Schramm VL, Schwartz SD. Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase. Biophysical Journal. 94: 4078-88. PMID 18234834 DOI: 10.1529/Biophysj.107.121913  0.42
2008 Murkin AS, Tyler PC, Schramm VL. Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects. Journal of the American Chemical Society. 130: 2166-7. PMID 18229929 DOI: 10.1021/Ja7104398  0.801
2008 Rinaldo-Matthis A, Murkin AS, Ramagopal UA, Clinch K, Mee SP, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL. L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase. Journal of the American Chemical Society. 130: 842-4. PMID 18154341 DOI: 10.1021/Ja710733G  0.781
2008 Schramm VL, Tyler PC. Transition State Analogue Inhibitors of N-Ribosyltransferases Iminosugars: From Synthesis to Therapeutic Applications. 177-208. DOI: 10.1002/9780470517437.ch8  0.421
2007 Gutierrez JA, Luo M, Singh V, Li L, Brown RL, Norris GE, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Schramm VL. Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. Acs Chemical Biology. 2: 725-34. PMID 18030989 DOI: 10.1021/Cb700166Z  0.562
2007 Evans GB, Furneaux RH, Kelly PM, Schramm VL, Tyler PC. Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes. Nucleic Acids Symposium Series (2004). 63-4. PMID 18029587 DOI: 10.1093/nass/nrm032  0.36
2007 Singh V, Luo M, Brown RL, Norris GE, Schramm VL. Transition-state structure of neisseria meningitides 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Journal of the American Chemical Society. 129: 13831-3. PMID 17956098 DOI: 10.1021/Ja0754204  0.541
2007 Taylor EA, Rinaldo-Matthis A, Li L, Ghanem M, Hazleton KZ, Cassera MB, Almo SC, Schramm VL. Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition. Biochemistry. 46: 12405-15. PMID 17918964 DOI: 10.1021/Bi7010256  0.796
2007 Schramm VL. Binding isotope effects: boon and bane. Current Opinion in Chemical Biology. 11: 529-36. PMID 17869163 DOI: 10.1016/j.cbpa.2007.07.013  0.343
2007 Schramm VL. Enzymatic transition state theory and transition state analogue design Journal of Biological Chemistry. 282: 28297-28300. PMID 17690091 DOI: 10.1074/jbc.R700018200  0.398
2007 Luo M, Singh V, Taylor EA, Schramm VL. Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases. Journal of the American Chemical Society. 129: 8008-17. PMID 17536804 DOI: 10.1021/Ja072122Y  0.789
2007 Taylor EA, Clinch K, Kelly PM, Li L, Evans GB, Tyler PC, Schramm VL. Acyclic ribooxacarbenium ion mimics as transition state analogues of human and malarial purine nucleoside phosphorylases. Journal of the American Chemical Society. 129: 6984-5. PMID 17497780 DOI: 10.1021/Ja071087S  0.782
2007 Tyler PC, Taylor EA, Fröhlich RF, Schramm VL. Synthesis of 5'-methylthio coformycins: specific inhibitors for malarial adenosine deaminase. Journal of the American Chemical Society. 129: 6872-9. PMID 17488013 DOI: 10.1021/Ja0708363  0.8
2007 Roday S, Saen-oon S, Schramm VL. Vinyldeoxyadenosine in a sarcin-ricin RNA loop and its binding to ricin toxin A-chain Biochemistry. 46: 6169-6182. PMID 17477546 DOI: 10.1021/Bi0621821  0.334
2007 Murkin AS, Birck MR, Rinaldo-Matthis A, Shi W, Taylor EA, Almo SC, Schramm VL. Neighboring group participation in the transition state of human purine nucleoside phosphorylase. Biochemistry. 46: 5038-49. PMID 17407325 DOI: 10.1021/Bi700147B  0.84
2007 Singh V, Schramm VL. Transition-state analysis of S. pneumoniae 5′-methylthioadenosine nucleosidase Journal of the American Chemical Society. 129: 2783-2795. PMID 17298059 DOI: 10.1021/Ja065082R  0.464
2007 Rinaldo-Matthis A, Wing C, Ghanem M, Deng H, Wu P, Gupta A, Tyler PC, Evans GB, Furneaux RH, Almo SC, Wang CC, Schramm VL. Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues. Biochemistry. 46: 659-68. PMID 17223688 DOI: 10.1021/Bi061515R  0.475
2006 Singh V, Schramm VL. Transition-state structure of human 5′-methylthioadenosine phosphorylase Journal of the American Chemical Society. 128: 14691-14696. PMID 17090056 DOI: 10.1021/ja065419p  0.393
2006 Singh V, Shi W, Almo SC, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Mee S, Zheng R, Schramm VL. Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae. Biochemistry. 45: 12929-41. PMID 17059210 DOI: 10.1021/Bi061184I  0.397
2006 Chattopadhyay S, Zhao R, Tsai E, Schramm VL, Goldman ID. The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity Molecular Cancer Therapeutics. 5: 2549-2555. PMID 17041099 DOI: 10.1158/1535-7163.Mct-06-0313  0.407
2006 Deng H, Murkin AS, Schramm VL. Phosphate activation in the ground state of purine nucleoside phosphorylase. Journal of the American Chemical Society. 128: 7765-71. PMID 16771490 DOI: 10.1021/Ja0570281  0.751
2006 Taylor Ringia EA, Tyler PC, Evans GB, Furneaux RH, Murkin AS, Schramm VL. Transition state analogue discrimination by related purine nucleoside phosphorylases. Journal of the American Chemical Society. 128: 7126-7. PMID 16734442 DOI: 10.1021/ja061403n  0.795
2006 Kim J, Malashkevich V, Roday S, Lisbin M, Schramm VL, Almo SC. Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. Biochemistry. 45: 6407-16. PMID 16700551 DOI: 10.1021/Bi0522394  0.422
2006 Lewis BE, Choytun N, Schramm VL, Bennet AJ. Transition states for glucopyranose interconversion Journal of the American Chemical Society. 128: 5049-5058. PMID 16608339 DOI: 10.1021/Ja0573054  0.533
2006 Clinch K, Evans GB, Fleet GW, Furneaux RH, Johnson SW, Lenz DH, Mee SP, Rands PR, Schramm VL, Taylor Ringia EA, Tyler PC. Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases. Organic & Biomolecular Chemistry. 4: 1131-9. PMID 16525558 DOI: 10.1039/B517883E  0.4
2005 Taylor Ringia EA, Schramm VL. Transition states and inhibitors of the purine nucleoside phosphorylase family. Current Topics in Medicinal Chemistry. 5: 1237-58. PMID 16305529 DOI: 10.2174/156802605774463088  0.608
2005 Schramm VL. Enzymatic transition states and transition state analogues Current Opinion in Structural Biology. 15: 604-613. PMID 16274984 DOI: 10.1016/j.sbi.2005.10.017  0.468
2005 Singh V, Lee JE, Núñez S, Howell PL, Schramm VL. Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues. Biochemistry. 44: 11647-59. PMID 16128565 DOI: 10.1021/Bi050863A  0.542
2005 Evans GB, Furneaux RH, Lenz DH, Painter GF, Schramm VL, Singh V, Tyler PC. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. Journal of Medicinal Chemistry. 48: 4679-89. PMID 16000004 DOI: 10.1021/Jm050269Z  0.512
2005 Lewandowicz A, Ringia EA, Ting LM, Kim K, Tyler PC, Evans GB, Zubkova OV, Mee S, Painter GF, Lenz DH, Furneaux RH, Schramm VL. Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases. The Journal of Biological Chemistry. 280: 30320-8. PMID 15961383 DOI: 10.1074/Jbc.M505033200  0.569
2005 Singh V, Evans GB, Lenz DH, Mason JM, Clinch K, Mee S, Painter GF, Tyler PC, Furneaux RH, Lee JE, Howell PL, Schramm VL. Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli. The Journal of Biological Chemistry. 280: 18265-73. PMID 15749708 DOI: 10.1074/Jbc.M414472200  0.537
2005 Lee JE, Singh V, Evans GB, Tyler PC, Furneaux RH, Cornell KA, Riscoe MK, Schramm VL, Howell PL. Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. The Journal of Biological Chemistry. 280: 18274-82. PMID 15746096 DOI: 10.1074/Jbc.M414471200  0.476
2005 Sauve AA, Moir RD, Schramm VL, Willis IM. Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Molecular Cell. 17: 595-601. PMID 15721262 DOI: 10.1016/J.Molcel.2004.12.032  0.313
2005 Schramm VL. Enzymatic transition states: Thermodynamics, dynamics and analogue design Archives of Biochemistry and Biophysics. 433: 13-26. PMID 15581562 DOI: 10.1016/j.abb.2004.08.035  0.489
2005 Ting LM, Shi W, Lewandowicz A, Singh V, Mwakingwe A, Birck MR, Ringia EA, Bench G, Madrid DC, Tyler PC, Evans GB, Furneaux RH, Schramm VL, Kim K. Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins. The Journal of Biological Chemistry. 280: 9547-54. PMID 15576366 DOI: 10.1074/Jbc.M412693200  0.31
2004 Deng H, Cahill SM, Abad JL, Lewandowicz A, Callender RH, Schramm VL, Jones RA. Active site contacts in the purine nucleoside phosphorylase--hypoxanthine complex by NMR and ab initio calculations. Biochemistry. 43: 15966-74. PMID 15595853 DOI: 10.1021/Bi048167I  0.353
2004 Deng H, Lewandowicz A, Schramm VL, Callender R. Activating the phosphate nucleophile at the catalytic site of purine nucleoside phosphorylase: a vibrational spectroscopic study. Journal of the American Chemical Society. 126: 9516-7. PMID 15291536 DOI: 10.1021/Ja049296P  0.31
2004 Schramm VL, Grubmeyer C. Phosphoribosyltransferase mechanisms and roles in nucleic acid metabolism. Progress in Nucleic Acid Research and Molecular Biology. 78: 261-304. PMID 15210333 DOI: 10.1016/S0079-6603(04)78007-1  0.436
2004 Birck MR, Schramm VL. Binding causes the remote [5'-3H]thymidine kinetic isotope effect in human thymidine phosphorylase. Journal of the American Chemical Society. 126: 6882-3. PMID 15174854 DOI: 10.1021/Ja0492642  0.522
2004 Evans GB, Furneaux RH, Schramm VL, Singh V, Tyler PC. Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase. Journal of Medicinal Chemistry. 47: 3275-81. PMID 15163207 DOI: 10.1021/Jm0306475  0.544
2004 Zhou GC, Parikh SL, Tyler PC, Evans GB, Furneaux RH, Zubkova OV, Benjes PA, Schramm VL. Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states. Journal of the American Chemical Society. 126: 5690-8. PMID 15125661 DOI: 10.1021/Ja038159+  0.584
2004 Roday S, Amukele T, Evans GB, Tyler PC, Furneaux RH, Schramm VL. Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state. Biochemistry. 43: 4923-33. PMID 15109250 DOI: 10.1021/bi0498499  0.395
2004 Sauve AA, Schramm VL. SIR2: The biochemical mehanism of NAD+-dependent protein deacetylation and ADP-ribosyl enzyme intermediates Current Medicinal Chemistry. 11: 807-826. PMID 15078167 DOI: 10.2174/0929867043455675  0.352
2004 Shi W, Ting LM, Kicska GA, Lewandowicz A, Tyler PC, Evans GB, Furneaux RH, Kim K, Almo SC, Schramm VL. Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. The Journal of Biological Chemistry. 279: 18103-6. PMID 14982926 DOI: 10.1074/Jbc.C400068200  0.391
2004 Birck MR, Schramm VL. Nucleophilic participation in the transition state for human thymidine phosphorylase. Journal of the American Chemical Society. 126: 2447-53. PMID 14982453 DOI: 10.1021/Ja039260H  0.56
2004 Deng H, Lewandowicz A, Cahill SM, Furneaux RH, Tyler PC, Girvin ME, Callender RH, Schramm VL. Assignment of downfield proton resonances in purine nucleoside phosphorylase immucillin-H complex by saturation-transferred NOEs. Biochemistry. 43: 1980-7. PMID 14967038 DOI: 10.1021/Bi0358115  0.379
2004 Lewandowicz A, Schramm VL. Transition State Analysis for Human and Plasmodium falciparum Purine Nucleoside Phosphorylases Biochemistry. 43: 1458-1468. PMID 14769022 DOI: 10.1021/Bi0359123  0.511
2004 Parikh SL, Schramm VL. Transition state structure for ADP-ribosylation of eukaryotic elongation factor 2 catalyzed by diphtheria toxin. Biochemistry. 43: 1204-12. PMID 14756556 DOI: 10.1021/Bi035907Z  0.498
2004 Singh V, Shi W, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL. Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry. 43: 9-18. PMID 14705926 DOI: 10.1021/Bi0358420  0.491
2003 Evans GB, Furneaux RH, Lewandowicz A, Schramm VL, Tyler PC. Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase. Journal of Medicinal Chemistry. 46: 5271-6. PMID 14613329 DOI: 10.1021/Jm030305Z  0.568
2003 Schramm VL. Transition state analogues for enzymes of nucleic acid metabolism Nucleic Acids Research. Supplement (2001). 107-108. PMID 14510403  0.495
2003 Evans GB, Furneaux RH, Tyler PC, Schramm VL. Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction. Organic Letters. 5: 3639-40. PMID 14507192 DOI: 10.1021/ol035293q  0.319
2003 Schramm VL. Enzymatic transition state poise and transition state analogues Accounts of Chemical Research. 36: 588-596. PMID 12924955 DOI: 10.1021/ar0200495  0.43
2003 Sauve AA, Schramm VL. Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry Biochemistry. 42: 9249-9256. PMID 12899610 DOI: 10.1021/Bi034959L  0.389
2003 Evans GB, Furneaux RH, Lewandowicz A, Schramm VL, Tyler PC. Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. Journal of Medicinal Chemistry. 46: 3412-23. PMID 12852771 DOI: 10.1021/Jm030145R  0.531
2003 Lewandowicz A, Tyler PC, Evans GB, Furneaux RH, Schramm VL. Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase. The Journal of Biological Chemistry. 278: 31465-8. PMID 12842889 DOI: 10.1074/jbc.C300259200  0.454
2003 Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL. Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase. Biochemistry. 42: 6057-66. PMID 12755607 DOI: 10.1021/Bi0343830  0.696
2003 Sauve AA, Cahill SM, Zech SG, Basso LA, Lewandowicz A, Santos DS, Grubmeyer C, Evans GB, Furneaux RH, Tyler PC, McDermott A, Girvin ME, Schramm VL. Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases. Biochemistry. 42: 5694-705. PMID 12741826 DOI: 10.1021/Bi034003A  0.727
2003 Lewis BE, Schramm VL. Binding equilibrium isotope effects for glucose at the catalytic domain of human brain hexokinase Journal of the American Chemical Society. 125: 4785-4798. PMID 12696897 DOI: 10.1021/Ja0298242  0.321
2003 Lewis BE, Schramm VL. Glucose binding isotope effects in the ternary complex of brain hexokinase demonstrate partial relief of ground-state destabilization Journal of the American Chemical Society. 125: 4672-4673. PMID 12696861 DOI: 10.1021/Ja029852K  0.367
2003 Evans GB, Furneaux RH, Gainsford GJ, Hanson JC, Kicska GA, Sauve AA, Schramm VL, Tyler PC. 8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases. Journal of Medicinal Chemistry. 46: 155-60. PMID 12502369 DOI: 10.1021/jm0203332  0.449
2003 Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL. Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase Biochemistry. 42: 6057-6066. DOI: 10.2210/Pdb1N3I/Pdb  0.656
2002 Kicska GA, Tyler PC, Evans GB, Furneaux RH, Shi W, Fedorov A, Lewandowicz A, Cahill SM, Almo SC, Schramm VL. Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase. Biochemistry. 41: 14489-98. PMID 12463747 DOI: 10.1021/Bi026636F  0.397
2002 Schramm VL. Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1587: 107-117. PMID 12084452 DOI: 10.1016/S0925-4439(02)00073-X  0.31
2002 Sauve AA, Schramm VL. Mechanism-based inhibitors of CD38: A mammalian cyclic ADP-ribose synthetase Biochemistry. 41: 8455-8463. PMID 12081495 DOI: 10.1021/Bi0258795  0.41
2002 Kicska GA, Tyler PC, Evans GB, Furneaux RH, Kim K, Schramm VL. Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum. The Journal of Biological Chemistry. 277: 3219-25. PMID 11707439 DOI: 10.1074/Jbc.M105905200  0.396
2002 Kicska GA, Tyler PC, Evans GB, Furneaux RH, Schramm VL, Kim K. Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase. The Journal of Biological Chemistry. 277: 3226-31. PMID 11706018 DOI: 10.1074/Jbc.M105906200  0.379
2001 Schramm VL, Shi W. Atomic motion in enzymatic reaction coordinates Current Opinion in Structural Biology. 11: 657-665. PMID 11751045 DOI: 10.1016/S0959-440X(01)00269-X  0.369
2001 Schramm VL. Transition state variation in enzymatic reactions Current Opinion in Chemical Biology. 5: 556-563. PMID 11578929 DOI: 10.1016/S1367-5931(00)00246-5  0.555
2001 Lewis BE, Schramm VL. Conformational equilibrium isotope effects in glucose by 13C NMR spectroscopy and computational studies Journal of the American Chemical Society. 123: 1327-1336. PMID 11456704 DOI: 10.1021/Ja003291K  0.33
2001 Shi W, Basso LA, Santos DS, Tyler PC, Furneaux RH, Blanchard JS, Almo SC, Schramm VL. Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry. 40: 8204-15. PMID 11444966 DOI: 10.1021/Bi010585P  0.598
2001 Basso LA, Santos DS, Shi W, Furneaux RH, Tyler PC, Schramm VL, Blanchard JS. Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts. Biochemistry. 40: 8196-203. PMID 11444965 DOI: 10.1021/Bi010584X  0.566
2001 Wang F, Shi W, Nieves E, Angeletti RH, Schramm VL, Grubmeyer C. A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase Biochemistry. 40: 8043-8054. PMID 11434773 DOI: 10.1021/bi010203f  0.369
2001 Tanaka KS, Chen XY, Ichikawa Y, Tyler PC, Furneaux RH, Schramm VL. Ricin A-chain inhibitors resembling the oxacarbenium ion transition state. Biochemistry. 40: 6845-51. PMID 11389598 DOI: 10.1021/Bi010499P  0.377
2001 Fedorov A, Shi W, Kicska G, Fedorov E, Tyler PC, Furneaux RH, Hanson JC, Gainsford GJ, Larese JZ, Schramm VL, Almo SC. Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis. Biochemistry. 40: 853-60. PMID 11170405 DOI: 10.1021/Bi002499F  0.465
2000 Wang F, Miles RW, Kicska G, Nieves E, Schramm VL, Angeletti RH. Immucillin-H binding to purine nucleoside phosphorylase reduces dynamic solvent exchange. Protein Science : a Publication of the Protein Society. 9: 1660-8. PMID 11045613 DOI: 10.1110/Ps.9.9.1660  0.422
2000 Shi W, Munagala NR, Wang CC, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC. Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,). Biochemistry. 39: 6781-90. PMID 10841757 DOI: 10.1021/Bi000128T  0.328
2000 Chen X, Berti PJ, Schramm VL. Transition-State Analysis for Depurination of DNA by Ricin A-Chain Journal of the American Chemical Society. 122: 6527-6534. DOI: 10.1021/Ja992751A  0.365
2000 Chen X, Berti PJ, Schramm VL. Ricin A-Chain:  Kinetic Isotope Effects and Transition State Structure with Stem-Loop RNA† Journal of the American Chemical Society. 122: 1609-1617. DOI: 10.1021/Ja992750I  0.425
2000 Sauve AA, Deng H, Angeletti RH, Schramm VL. A covalent intermediate in CD38 is responsible for ADP-ribosylation and cyclization reactions Journal of the American Chemical Society. 122: 7855-7859. DOI: 10.1021/Ja001139C  0.331
2000 Evans GB, Furneaux RH, Gainsford GJ, Schramm VL, Tyler PC. Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases Tetrahedron. 56: 3053-3062. DOI: 10.1016/S0040-4020(00)00194-0  0.422
2000 Braunheim BB, Bagdassarian CK, Schramm VL, Schwartz SD. Quantum neural networks can predict binding free energies for enzymatic inhibitors International Journal of Quantum Chemistry. 78: 195-204. DOI: 10.1002/(Sici)1097-461X(2000)78:3<195::Aid-Qua7>3.0.Co;2-G  0.336
1999 Furneaux RH, Schramm VL, Tyler PC. Transition state analogue inhibitors of protozoan nucleoside hydrolases. Bioorganic & Medicinal Chemistry. 7: 2599-606. PMID 10632070 DOI: 10.1016/S0968-0896(99)00210-2  0.348
1999 Miles RW, Tyler PC, Evans GB, Furneaux RH, Parkin DW, Schramm VL. Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases. Biochemistry. 38: 13147-54. PMID 10529186 DOI: 10.1021/Bi990829U  0.538
1999 Schramm VL. Enzymatic transition-state analysis and transition-state analogs. Methods in Enzymology. 308: 301-55. PMID 10507010 DOI: 10.1016/S0076-6879(99)08015-5  0.436
1999 Shi W, Li CM, Tyler PC, Furneaux RH, Cahill SM, Girvin ME, Grubmeyer C, Schramm VL, Almo SC. The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. Biochemistry. 38: 9872-80. PMID 10433693 DOI: 10.1021/Bi990664P  0.461
1999 Shi W, Schramm VL, Almo SC. Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-Å crystal structure Journal of Biological Chemistry. 274: 21114-21120. PMID 10409664 DOI: 10.1074/Jbc.274.30.21114  0.457
1999 Shi W, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC. The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor. Nature Structural Biology. 6: 588-93. PMID 10360366 DOI: 10.1038/9376  0.561
1999 Li CM, Tyler PC, Furneaux RH, Kicska G, Xu Y, Grubmeyer C, Girvin ME, Schramm VL. Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases. Nature Structural Biology. 6: 582-7. PMID 10360365 DOI: 10.1038/9367  0.526
1999 Hall MB, Margl P, Náray-Szabó G, Schramm VL, Truhlar DG, Van Santen RA, Warshel A, Whitten JL. Quantum catalysis: The modeling of catalytic transition states Acs Symposium Series. 721: 2-17.  0.315
1998 Schramm VL. Enzymatic transition states and transition state analog design. Annual Review of Biochemistry. 67: 693-720. PMID 9759501 DOI: 10.1146/Annurev.Biochem.67.1.693  0.584
1998 Sauve AA, Munshi C, Lee HC, Schramm VL. The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries Biochemistry. 37: 13239-13249. PMID 9748331 DOI: 10.1021/Bi981248S  0.422
1998 Schramm VL. Enzymatic N-riboside scission in RNA and RNA precursors. Current Opinion in Chemical Biology. 1: 323-31. PMID 9667869 DOI: 10.1016/S1367-5931(97)80069-5  0.362
1998 Miles RW, Tyler PC, Furneaux RH, Bagdassarian CK, Schramm VL. One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase. Biochemistry. 37: 8615-21. PMID 9628722 DOI: 10.1021/bi980658d  0.477
1998 Degano M, Almo SC, Sacchettini JC, Schramm VL. Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor Biochemistry. 37: 6277-6285. PMID 9572842 DOI: 10.1021/Bi973012E  0.449
1998 Scheuring J, Berti PJ, Schramm VL. Transition-State Structure for the ADP-Ribosylation of Recombinant Giα1Subunits by Pertussis Toxin† Biochemistry. 37: 2748-2758. DOI: 10.1021/Bi972594X  0.538
1997 Berti PJ, Blanke SR, Schramm VL. Transition State Structure for the Hydrolysis of NAD Catalyzed by Diphtheria Toxin. Journal of the American Chemical Society. 119: 12079-12088. PMID 19079637 DOI: 10.1021/Ja971317A  0.373
1997 Scheuring J, Schramm VL. Pertussis toxin: transition state analysis for ADP-ribosylation of G-protein peptide alphai3C20. Biochemistry. 36: 8215-23. PMID 9204866 DOI: 10.1021/Bi970379A  0.519
1997 Parkin DW, Limberg G, Tyler PC, Furneaux RH, Chen XY, Schramm VL. Isozyme-specific transition state inhibitors for the trypanosomal nucleoside hydrolases. Biochemistry. 36: 3528-34. PMID 9132003 DOI: 10.1021/Bi962319V  0.569
1997 Scheuring J, Schramm VL. Kinetic isotope effect characterization of the transition state for oxidized nicotinamide adenine dinucleotide hydrolysis by pertussis toxin. Biochemistry. 36: 4526-34. PMID 9109661 DOI: 10.1021/Bi962841H  0.535
1997 Berti PJ, Schramm VL. Transition State Structure of the Solvolytic Hydrolysis of NAD+ † Journal of the American Chemical Society. 119: 12069-12078. DOI: 10.1021/JA971316I  0.427
1997 Rising KA, Schramm VL. Transition State Analysis of NAD+Hydrolysis by the Cholera Toxin Catalytic Subunit Journal of the American Chemical Society. 119: 27-37. DOI: 10.1021/Ja9621915  0.419
1997 Furneaux RH, Limberg G, Tyler PC, Schramm VL. Synthesis of transition state inhibitors for N-riboside hydrolases and transferases Tetrahedron. 53: 2915-2930. DOI: 10.1016/S0040-4020(96)01172-6  0.418
1996 Deng H, Chan AW, Bagdassarian CK, Estupiñán B, Ganem B, Callender RH, Schramm VL. Trypanosomal nucleoside hydrolase. Resonance Raman spectroscopy of a transition-state inhibitor complex. Biochemistry. 35: 6037-47. PMID 8634245 DOI: 10.1021/Bi9526544  0.559
1996 Bagdassarian CK, Schramm VL, Schwartz SD. Molecular Electrostatic Potential Analysis for Enzymatic Substrates, Competitive Inhibitors, and Transition-State Inhibitors Journal of the American Chemical Society. 118: 8825-8836. DOI: 10.1021/Ja952781N  0.506
1996 Scheuring J, Schramm V. Kinetic isotope effect studies on the transition state of pertussis toxin Toxicon. 34: 326. DOI: 10.1016/0041-0101(96)80975-5  0.427
1996 Schramm VL, Horenstein BA, Bagdassarian CK, Schwartz SD, Berti PJ, Rising KA, Scheuring J, Kline PC, Parkin DW, Merkler DJ. Enzymatic transition states and inhibitor design from principles of classical and quantum chemistry International Journal of Quantum Chemistry. 60: 1805-1813. DOI: 10.1002/(Sici)1097-461X(1996)60:8<1805::Aid-Qua8>3.0.Co;2-1  0.586
1996 Bagdassarian CK, Braunheim BB, Schramm VL, Schwartz SD. Quantitative measures of molecular similarity: Methods to analyze transition-state analogs for enzymatic reactions International Journal of Quantum Chemistry. 60: 1797-1804. DOI: 10.1002/(Sici)1097-461X(1996)60:8<1797::Aid-Qua7>3.0.Co;2-T  0.473
1995 Kline PC, Schramm VL. Pre-steady-state transition-state analysis of the hydrolytic reaction catalyzed by purine nucleoside phosphorylase. Biochemistry. 34: 1153-62. PMID 7827065 DOI: 10.1021/Bi00004A008  0.556
1995 Parkin DW, Schramm VL. Binding modes for substrate and a proposed transition-state analogue of protozoan nucleoside hydrolase. Biochemistry. 34: 13961-6. PMID 7577992 DOI: 10.1021/Bi00042A030  0.513
1995 Boutellier M, Ganem B, Horenstein BA, Schramm VL. Design and Synthesis of D-Ribofuranoamidrazones as Inhibitors of Nucleoside Processing Enzymes Synlett. 1995: 510-512. DOI: 10.1055/S-1995-5263  0.328
1995 Scheuring J, Schramm VL. Stereochemistry of the ADP-Ribosylation Catalyzed by Pertussis Toxin Journal of the American Chemical Society. 117: 12653-12654. DOI: 10.1021/Ja00155A037  0.311
1994 Kline PC, Schramm VL. Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction. Biochemistry. 32: 13212-9. PMID 8241176 DOI: 10.1021/Bi00211A033  0.485
1994 Boutellier M, Horenstein BA, Semenyaka A, Schramm VL, Ganem B. Amidrazone analogues of D-ribofuranose as transition-state inhibitors of nucleoside hydrolase. Biochemistry. 33: 3994-4000. PMID 8142404 DOI: 10.1021/Bi00179A028  0.411
1994 Ehrlich JI, Schramm VL. Electrostatic potential surface analysis of the transition state for AMP nucleosidase and for formycin 5'-phosphate, a transition-state inhibitor. Biochemistry. 33: 8890-6. PMID 8043576 DOI: 10.1021/Bi00196A005  0.574
1994 Rising KA, Schramm VL. Enzymic Synthesis of NAD+ with the Specific Incorporation of Atomic Labels Journal of the American Chemical Society. 116: 6531-6536. DOI: 10.1021/Ja00094A006  0.316
1993 Merkler DJ, Schramm VL. Catalytic mechanism of yeast adenosine 5′-monophosphate deaminase. Zinc content, substrate specificity, pH studies, and solvent isotope effects Biochemistry. 32: 5792-5799. PMID 8504099 DOI: 10.1021/Bi00073A011  0.455
1993 Horenstein BA, Schramm VL. Correlation of the molecular electrostatic potential surface of an enzymatic transition state with novel transition-state inhibitors Biochemistry. 32: 9917-9925. PMID 8399161 DOI: 10.1021/Bi00089A007  0.569
1993 Horenstein BA, Schramm VL. Electronic nature of the transition state for nucleoside hydrolase. A blueprint for inhibitor design Biochemistry. 32: 7089-7097. PMID 8343502 DOI: 10.1021/Bi00079A004  0.546
1993 Merkler DJ, Kline PC, Weiss P, Schramm VL. Transition-state analysis of AMP deaminase Biochemistry. 32: 12993-13001. PMID 8241153 DOI: 10.1021/Bi00211A007  0.361
1993 Horenstein BA, Schramm VL. Correlation of the molecular electrostatic potential surface of an enzymic transition state with novel transition-state inhibitors Biochemistry. 32: 9917-9925. DOI: 10.1021/BI00089A007  0.44
1993 Horenstein BA, Zabinski RF, Schramm VL. A new class of C-nucleoside analogues. 1-(S)-aryl-1,4-dideoxy-1,4-imino-D-ribitols, transition state analogue inhibitors of nucleoside hydrolase Tetrahedron Letters. 34: 7213-7216. DOI: 10.1016/S0040-4039(00)79290-2  0.434
1992 Kline PC, Schramm VL. Purine nucleoside phosphorylase. Inosine hydrolysis, tight binding of the hypoxanthine intermediate, and third-the-sites reactivity. Biochemistry. 31: 5964-73. PMID 1627539 DOI: 10.1021/Bi00141A003  0.436
1991 Parkin DW, Mentch F, Banks GA, Horenstein BA, Schramm VL. Transition-state analysis of a Vmax mutant of AMP nucleosidase by the application of heavy-atom kinetic isotope effects. Biochemistry. 30: 4586-94. PMID 2021651 DOI: 10.1021/Bi00232A032  0.479
1991 Chen CY, Sato Y, Schramm VL. Isotope trapping and positional isotope exchange with rat and chicken liver phosphoenolpyruvate carboxykinases. Biochemistry. 30: 4143-51. PMID 2021605 DOI: 10.1021/Bi00231A006  0.327
1991 Horenstein BA, Parkin DW, Estupiñán B, Schramm VL. Transition-State Analysis of Nucleoside Hydrorlase from Crithidia fasciculata Biochemistry. 30: 10788-10795. PMID 1931998 DOI: 10.1021/Bi00108A026  0.5
1990 Merkler DJ, Brenowitz M, Schramm VL. The rate constant describing slow-onset inhibition of yeast AMP deaminase by coformycin analogues is independent of inhibitor structure Biochemistry®. 29: 8358-8364. PMID 2252896 DOI: 10.1021/Bi00488A023  0.407
1990 Wente SR, Villalba M, Schramm VL, Rosen OM. Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 87: 2805-9. PMID 2157215 DOI: 10.1073/Pnas.87.7.2805  0.303
1987 Mentch F, Parkin DW, Schramm VL. Transition-state structures for N-glycoside hydrolysis of AMP by acid and by AMP nucleosidase in the presence and absence of allosteric activator. Biochemistry. 26: 921-30. PMID 3552038 DOI: 10.1021/BI00377A037  0.489
1987 Parkin DW, Schramm VL. Catalytic and allosteric mechanism of AMP nucleosidase from primary, beta-secondary, and multiple heavy atom kinetic isotope effects. Biochemistry. 26: 913-20. PMID 3552037 DOI: 10.1021/BI00377A036  0.335
1986 DeWolf WE, Emig FA, Schramm VL. AMP nucleosidase: kinetic mechanism and thermodynamics. Biochemistry. 25: 4132-40. PMID 3741845 DOI: 10.1021/BI00362A022  0.302
1972 Schramm VL, Hochstein LI. Purification, crystallization, and subunit structure of allosteric adenosine 5'-monophosphate nucleosidase. Biochemistry. 11: 2777-83. PMID 5041898  0.615
1971 Schramm VL, Hochstein LI. Stabilization of allosteric adenosine monophosphate nucleosidase by inorganic salts, substrate, and essential activator. Biochemistry. 10: 3411-7. PMID 5118623  0.64
1971 Schramm VL, Morrison JF. Studies on the allosteric modification of nucleoside diphosphatase activity by magnesium nucleoside triphosphates and inosine diphosphate. Biochemistry. 10: 2272-7. PMID 4329873 DOI: 10.1021/Bi00788A014  0.462
1970 Schramm VL, Morrison JF. Studies on an aged preparation of nucleoside diphosphatase. Kinetics and reaction mechanism. Biochemistry. 9: 671-7. PMID 4313473 DOI: 10.1021/Bi00805A029  0.496
1969 Schramm VL, Morrison JF. Kinetic studies of the mechanism and allosteric activation of the reaction catalyzed by nucleoside diphosphatase. Biochemistry. 8: 3821-8. PMID 4309537 DOI: 10.1021/Bi00837A048  0.472
1968 Schramm VL, Morrison JF. Purification, properties, and allosteric activation of nucleoside diphosphatase. Biochemistry. 7: 3642-52. PMID 4300705 DOI: 10.1021/Bi00850A043  0.476
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