Mehdi Mollapour - Publications

Affiliations: 
University College London, London, United Kingdom 

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sager RA, Woodford MR, Backe SJ, Makedon AM, Baker-Williams AJ, DiGregorio BT, Loiselle DR, Haystead TA, Zachara NE, Prodromou C, Bourboulia D, Schmidt LS, Linehan WM, Bratslavsky G, Mollapour M. Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90. Cell Reports. 26: 1344-1356.e5. PMID 30699359 DOI: 10.1016/j.celrep.2019.01.018  0.64
2017 Dushukyan N, Dunn DM, Sager RA, Woodford MR, Loiselle DR, Daneshvar M, Baker-Williams AJ, Chisholm JD, Truman AW, Vaughan CK, Haystead TA, Bratslavsky G, Bourboulia D, Mollapour M. Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer. Cell Reports. 21: 1883-1895. PMID 29141220 DOI: 10.1016/j.celrep.2017.10.074  0.64
2017 Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, ... Mollapour M, et al. Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. The Embo Journal. PMID 29127155 DOI: 10.15252/embj.201796700  0.64
2016 Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, ... ... Mollapour M, et al. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nature Communications. 7: 12037. PMID 27353360 DOI: 10.1038/ncomms12037  0.64
2016 Woodford MR, Truman AW, Dunn DM, Jensen SM, Cotran R, Bullard R, Abouelleil M, Beebe K, Wolfgeher D, Wierzbicki S, Post DE, Caza T, Tsutsumi S, Panaretou B, Kron SJ, ... ... Mollapour M, et al. Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors. Cell Reports. 14: 872-84. PMID 26804907 DOI: 10.1016/j.celrep.2015.12.084  0.64
2015 Wolfgeher D, Dunn DM, Woodford MR, Bourboulia D, Bratslavsky G, Mollapour M, Kron SJ, Truman AW. The dynamic interactome of human Aha1 upon Y223 phosphorylation. Data in Brief. 5: 752-5. PMID 26693507 DOI: 10.1016/j.dib.2015.10.028  0.64
2015 Daugherty M, Blakely S, Shapiro O, Vourganti S, Mollapour M, Bratslavsky G. Chromophobe RCC is the most common non-clear RCC in young women: results from the SEER database. The Journal of Urology. PMID 26555952 DOI: 10.1016/j.juro.2015.10.177  0.64
2015 Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, ... ... Mollapour M, et al. c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells. Cell Reports. 12: 1006-18. PMID 26235616 DOI: 10.1016/j.celrep.2015.07.004  0.64
2014 Mollapour M, Bourboulia D, Beebe K, Woodford MR, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee MJ, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, et al. Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors. Molecular Cell. 53: 317-29. PMID 24462205 DOI: 10.1016/j.molcel.2013.12.007  0.64
2013 Beebe K, Mollapour M, Scroggins B, Prodromou C, Xu W, Tokita M, Taldone T, Pullen L, Zierer BK, Lee MJ, Trepel J, Buchner J, Bolon D, Chiosis G, Neckers L. Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors. Oncotarget. 4: 1065-74. PMID 23867252  0.64
2012 Iwai A, Bourboulia D, Mollapour M, Jensen-Taubman S, Lee S, Donnelly AC, Yoshida S, Miyajima N, Tsutsumi S, Smith AK, Sun D, Wu X, Blagg BS, Trepel JB, Stetler-Stevenson WG, et al. Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells. Cell Cycle (Georgetown, Tex.). 11: 3649-55. PMID 22935698 DOI: 10.4161/cc.21926  0.64
2012 Xu W, Mollapour M, Prodromou C, Wang S, Scroggins BT, Palchick Z, Beebe K, Siderius M, Lee MJ, Couvillon A, Trepel JB, Miyata Y, Matts R, Neckers L. Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine. Molecular Cell. 47: 434-43. PMID 22727666 DOI: 10.1016/j.molcel.2012.05.015  0.64
2012 Tsutsumi S, Mollapour M, Prodromou C, Lee CT, Panaretou B, Yoshida S, Mayer MP, Neckers LM. Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity. Proceedings of the National Academy of Sciences of the United States of America. 109: 2937-42. PMID 22315411 DOI: 10.1073/pnas.1114414109  0.64
2012 Mollapour M, Piper PW. Activity of the yeast zinc-finger transcription factor War1 is lost with alanine mutation of two putative phosphorylation sites in the activation domain. Yeast (Chichester, England). 29: 39-44. PMID 22113732 DOI: 10.1002/yea.1915  0.64
2011 Mollapour M, Tsutsumi S, Truman AW, Xu W, Vaughan CK, Beebe K, Konstantinova A, Vourganti S, Panaretou B, Piper PW, Trepel JB, Prodromou C, Pearl LH, Neckers L. Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. Molecular Cell. 41: 672-81. PMID 21419342 DOI: 10.1016/j.molcel.2011.02.011  0.64
2011 Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS. A systematic protocol for the characterization of Hsp90 modulators. Bioorganic & Medicinal Chemistry. 19: 684-92. PMID 21129982 DOI: 10.1016/j.bmc.2010.10.029  0.64
2010 Mollapour M, Tsutsumi S, Donnelly AC, Beebe K, Tokita MJ, Lee MJ, Lee S, Morra G, Bourboulia D, Scroggins BT, Colombo G, Blagg BS, Panaretou B, Stetler-Stevenson WG, Trepel JB, et al. Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Molecular Cell. 37: 333-43. PMID 20159553 DOI: 10.1016/j.molcel.2010.01.005  0.64
2009 Tsutsumi S, Mollapour M, Graf C, Lee CT, Scroggins BT, Xu W, Haslerova L, Hessling M, Konstantinova AA, Trepel JB, Panaretou B, Buchner J, Mayer MP, Prodromou C, Neckers L. Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain. Nature Structural & Molecular Biology. 16: 1141-7. PMID 19838189 DOI: 10.1038/nsmb.1682  0.64
2009 Mollapour M, Shepherd A, Piper PW. Presence of the Fps1p aquaglyceroporin channel is essential for Hog1p activation, but suppresses Slt2(Mpk1)p activation, with acetic acid stress of yeast. Microbiology (Reading, England). 155: 3304-11. PMID 19608606 DOI: 10.1099/mic.0.030502-0  0.64
2009 Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L. Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Molecular and Cellular Biology. 29: 4080-90. PMID 19470762 DOI: 10.1128/MCB.00483-09  0.64
2009 Millson SH, Nuttall JM, Mollapour M, Piper PW. The Hsp90/Cdc37p chaperone system is a determinant of molybdate resistance in Saccharomyces cerevisiae. Yeast (Chichester, England). 26: 339-47. PMID 19399909 DOI: 10.1002/yea.1670  0.64
2008 Vaughan CK, Mollapour M, Smith JR, Truman A, Hu B, Good VM, Panaretou B, Neckers L, Clarke PA, Workman P, Piper PW, Prodromou C, Pearl LH. Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molecular Cell. 31: 886-95. PMID 18922470 DOI: 10.1016/j.molcel.2008.07.021  0.64
2008 Mollapour M, Shepherd A, Piper PW. Novel stress responses facilitate Saccharomyces cerevisiae growth in the presence of the monocarboxylate preservatives. Yeast (Chichester, England). 25: 169-77. PMID 18240334 DOI: 10.1002/yea.1576  0.64
2007 Millson SH, Truman AW, Rácz A, Hu B, Panaretou B, Nuttall J, Mollapour M, Söti C, Piper PW. Expressed as the sole Hsp90 of yeast, the α and β isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90β generates sensitivity to the Hsp90 inhibitor radicicol Febs Journal. 274: 4453-4463. PMID 17681020 DOI: 10.1111/j.1742-4658.2007.05974.x  0.64
2007 Mollapour M, Piper PW. Hog1 mitogen-activated protein kinase phosphorylation targets the yeast Fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic acid. Molecular and Cellular Biology. 27: 6446-56. PMID 17620418 DOI: 10.1128/MCB.02205-06  0.64
2007 Truman AW, Millson SH, Nuttall JM, Mollapour M, Prodromou C, Piper PW. In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity Eukaryotic Cell. 6: 744-752. PMID 17293484 DOI: 10.1128/EC.00009-07  0.64
2006 Mollapour M, Piper PW. Hog1p mitogen-activated protein kinase determines acetic acid resistance in Saccharomyces cerevisiae. Fems Yeast Research. 6: 1274-80. PMID 17156024 DOI: 10.1111/j.1567-1364.2006.00118.x  0.64
2006 Truman AW, Millson SH, Nuttall JM, King V, Mollapour M, Prodromou C, Pearl LH, Piper PW. Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase Eukaryotic Cell. 5: 1914-1924. PMID 16950928 DOI: 10.1128/EC.00263-06  0.64
2006 Mollapour M, Phelan JP, Millson SH, Piper PW, Cooke FT. Weak acid and alkali stress regulate phosphatidylinositol bisphosphate synthesis in Saccharomyces cerevisiae. The Biochemical Journal. 395: 73-80. PMID 16316315 DOI: 10.1042/BJ20051765  0.64
2005 Hu B, Liao C, Millson SH, Mollapour M, Prodromou C, Pearl LH, Piper PW, Panaretou B. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Molecular Microbiology. 55: 1735-50. PMID 15752197 DOI: 10.1111/j.1365-2958.2005.04531.x  0.64
2005 Harris N, Bachler M, Costa V, Mollapour M, Moradas-Ferreira P, Piper PW. Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu(2+)-deficient or an active Cu,Zn-superoxide dismutase. Aging Cell. 4: 41-52. PMID 15659212 DOI: 10.1111/j.1474-9726.2005.00142.x  0.64
2004 Mollapour M, Fong D, Balakrishnan K, Harris N, Thompson S, Schüller C, Kuchler K, Piper PW. Screening the yeast deletant mutant collection for hypersensitivity and hyper-resistance to sorbate, a weak organic acid food preservative. Yeast (Chichester, England). 21: 927-46. PMID 15334557 DOI: 10.1002/yea.1141  0.64
2004 Schüller C, Mamnun YM, Mollapour M, Krapf G, Schuster M, Bauer BE, Piper PW, Kuchler K. Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Molecular Biology of the Cell. 15: 706-20. PMID 14617816 DOI: 10.1091/mbc.E03-05-0322  0.64
2003 Piper PW, Millson SH, Mollapour M, Panaretou B, Siligardi G, Pearl LH, Prodromou C. Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast. European Journal of Biochemistry. 270: 4689-95. PMID 14622256  0.64
2003 Bauer BE, Rossington D, Mollapour M, Mamnun Y, Kuchler K, Piper PW. Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants. European Journal of Biochemistry. 270: 3189-95. PMID 12869194  0.64
2003 Harris N, Costa V, MacLean M, Mollapour M, Moradas-Ferreira P, Piper PW. Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells. Free Radical Biology & Medicine. 34: 1599-606. PMID 12788479  0.64
2003 Hatzixanthis K, Mollapour M, Seymour I, Bauer BE, Krapf G, Schüller C, Kuchler K, Piper PW. Moderately lipophilic carboxylate compounds are the selective inducers of the Saccharomyces cerevisiae Pdr12p ATP-binding cassette transporter. Yeast (Chichester, England). 20: 575-85. PMID 12734796 DOI: 10.1002/yea.981  0.64
2003 Kren A, Mamnun YM, Bauer BE, Schüller C, Wolfger H, Hatzixanthis K, Mollapour M, Gregori C, Piper P, Kuchler K. War1p, a novel transcription factor controlling weak acid stress response in yeast. Molecular and Cellular Biology. 23: 1775-85. PMID 12588995 DOI: 10.1128/mcb.23.5.1775-1785.2003  0.44
2003 Piper PW, Panaretou B, Millson SH, Truman A, Mollapour M, Pearl LH, Prodromou C. Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. Gene. 302: 165-70. PMID 12527207  0.64
2002 Piper PW, Jones GW, Bringloe D, Harris N, MacLean M, Mollapour M. The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Aging Cell. 1: 149-57. PMID 12882345  0.64
2002 Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, et al. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Molecular Cell. 10: 1307-18. PMID 12504007 DOI: 10.1016/S1097-2765(02)00785-2  0.64
Show low-probability matches.