| Year |
Citation |
Score |
| 2021 |
Spies J, Polasek-Sedlackova H, Lukas J, Somyajit K. Homologous Recombination as a Fundamental Genome Surveillance Mechanism during DNA Replication. Genes. 12. PMID 34946909 DOI: 10.3390/genes12121960 |
0.783 |
|
| 2021 |
Somyajit K, Spies J, Coscia F, Kirik U, Rask MB, Lee JH, Neelsen KJ, Mund A, Jensen LJ, Paull TT, Mann M, Lukas J. Homology-directed repair protects the replicating genome from metabolic assaults. Developmental Cell. 56: 461-477.e7. PMID 33621493 DOI: 10.1016/j.devcel.2021.01.011 |
0.79 |
|
| 2020 |
Sedlackova H, Rask MB, Gupta R, Choudhary C, Somyajit K, Lukas J. Equilibrium between nascent and parental MCM proteins protects replicating genomes. Nature. PMID 33087936 DOI: 10.1038/s41586-020-2842-3 |
0.781 |
|
| 2020 |
Ercilla A, Benada J, Amitash S, Zonderland G, Baldi G, Somyajit K, Ochs F, Costanzo V, Lukas J, Toledo L. Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication. Cell Reports. PMID 32075739 DOI: 10.1016/J.Celrep.2020.01.067 |
0.789 |
|
| 2019 |
Ochs F, Karemore G, Miron E, Brown J, Sedlackova H, Rask MB, Lampe M, Buckle V, Schermelleh L, Lukas J, Lukas C. Stabilization of chromatin topology safeguards genome integrity. Nature. 574: 571-574. PMID 31645724 DOI: 10.1038/S41586-019-1659-4 |
0.556 |
|
| 2019 |
Spies J, Lukas C, Somyajit K, Rask MB, Lukas J, Neelsen KJ. 53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage. Nature Cell Biology. 21: 487-497. PMID 30804506 DOI: 10.1038/S41556-019-0293-6 |
0.797 |
|
| 2018 |
Bennetzen MV, Kosar M, Bunkenborg J, Payne MR, Bartkova J, Lindström MS, Lukas J, Andersen JS, Bartek J, Larsen DH. DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy. Cell Cycle (Georgetown, Tex.). PMID 30196736 DOI: 10.1080/15384101.2018.1515552 |
0.484 |
|
| 2018 |
Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, Typas D, Lammers M, Mailand N, Nussenzweig A, Lukas J, Choudhary C. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Cell. PMID 29656893 DOI: 10.1016/J.Cell.2018.03.050 |
0.785 |
|
| 2018 |
Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, et al. Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biology. 19: 37. PMID 29548335 DOI: 10.1186/S13059-018-1401-9 |
0.349 |
|
| 2017 |
Somyajit K, Gupta R, Sedlackova H, Neelsen KJ, Ochs F, Rask MB, Choudhary C, Lukas J. Redox-sensitive alteration of replisome architecture safeguards genome integrity. Science (New York, N.Y.). 358: 797-802. PMID 29123070 DOI: 10.1126/Science.Aao3172 |
0.75 |
|
| 2017 |
Toledo L, Neelsen KJ, Lukas J. Replication Catastrophe: When a Checkpoint Fails because of Exhaustion. Molecular Cell. 66: 735-749. PMID 28622519 DOI: 10.1016/J.Molcel.2017.05.001 |
0.567 |
|
| 2016 |
Sotiriou SK, Kamileri I, Lugli N, Evangelou K, Da-Ré C, Huber F, Padayachy L, Tardy S, Nicati NL, Barriot S, Ochs F, Lukas C, Lukas J, Gorgoulis VG, Scapozza L, et al. Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks. Molecular Cell. 64: 1127-1134. PMID 27984746 DOI: 10.1016/J.Molcel.2016.10.038 |
0.588 |
|
| 2016 |
S Pedersen R, Karemore G, Gudjonsson T, Rask MB, Neumann B, Hériché JK, Pepperkok R, Ellenberg J, Gerlich DW, Lukas J, Lukas C. Profiling DNA damage response following mitotic perturbations. Nature Communications. 7: 13887. PMID 27976684 DOI: 10.1038/Ncomms13887 |
0.587 |
|
| 2016 |
Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C. 53BP1 fosters fidelity of homology-directed DNA repair. Nature Structural & Molecular Biology. 23: 714-21. PMID 27348077 DOI: 10.1038/Nsmb.3251 |
0.791 |
|
| 2016 |
Moudry P, Watanabe K, Wolanin KM, Bartkova J, Wassing IE, Watanabe S, Strauss R, Troelsgaard Pedersen R, Oestergaard VH, Lisby M, Andújar-Sánchez M, Maya-Mendoza A, Esashi F, Lukas J, Bartek J. TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. The Journal of Cell Biology. PMID 26811421 DOI: 10.1083/Jcb.201507042 |
0.554 |
|
| 2015 |
Lukas J, Altmeyer M. A lncRNA to repair DNA. Embo Reports. 16: 1413-4. PMID 26420434 DOI: 10.15252/Embr.201541309 |
0.49 |
|
| 2015 |
Altmeyer M, Neelsen KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grøfte M, Rask MB, Streicher W, Jungmichel S, Nielsen ML, Lukas J. Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose). Nature Communications. 6: 8088. PMID 26286827 DOI: 10.1038/Ncomms9088 |
0.382 |
|
| 2015 |
Zong D, Callén E, Pegoraro G, Lukas C, Lukas J, Nussenzweig A. Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining. Nucleic Acids Research. 43: 4950-61. PMID 25916843 DOI: 10.1093/Nar/Gkv336 |
0.542 |
|
| 2014 |
Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, et al. The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage Nature Cell Biology. 16: 792-803. PMID 25064736 DOI: 10.1038/Ncb3007 |
0.486 |
|
| 2013 |
Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J. XATR prohibits replication catastrophe by preventing global exhaustion of RPA Cell. 155: X1088-1103. PMID 24267891 DOI: 10.1016/J.Cell.2013.10.043 |
0.561 |
|
| 2013 |
Watanabe S, Watanabe K, Akimov V, Bartkova J, Blagoev B, Lukas J, Bartek J. JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks. Nature Structural & Molecular Biology. 20: 1425-33. PMID 24240613 DOI: 10.1038/Nsmb.2702 |
0.567 |
|
| 2013 |
Yamada M, Watanabe K, Mistrik M, Vesela E, Protivankova I, Mailand N, Lee M, Masai H, Lukas J, Bartek J. ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress. Genes & Development. 27: 2459-72. PMID 24240236 DOI: 10.1101/Gad.224568.113 |
0.585 |
|
| 2013 |
Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML. Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. Molecular Cell. 52: 272-85. PMID 24055347 DOI: 10.1016/J.Molcel.2013.08.026 |
0.313 |
|
| 2013 |
Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J. The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling Molecular Cell. 52: 206-220. PMID 24055346 DOI: 10.1016/J.Molcel.2013.08.025 |
0.534 |
|
| 2013 |
Altmeyer M, Lukas J. XGuarding against collateral damage during chromatin transactions Cell. 153. PMID 23791174 DOI: 10.1016/J.Cell.2013.05.044 |
0.31 |
|
| 2013 |
Bennetzen MV, Larsen DH, Dinant C, Watanabe S, Bartek J, Lukas J, Andersen JS. Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response. Cell Cycle (Georgetown, Tex.). 12: 1688-95. PMID 23656789 DOI: 10.4161/Cc.24758 |
0.488 |
|
| 2013 |
Lukas J, Lukas C. Shielding broken DNA for a quick fix Science. 339: 652-653. PMID 23393250 DOI: 10.1126/Science.1234602 |
0.546 |
|
| 2013 |
Altmeyer M, Lukas J. To spread or not to spread-chromatin modifications in response to DNA damage Current Opinion in Genetics and Development. 23: 156-165. PMID 23312207 DOI: 10.1016/J.Gde.2012.11.001 |
0.564 |
|
| 2012 |
Mosbech A, Gibbs-Seymour I, Kagias K, Thorslund T, Beli P, Povlsen L, Nielsen SV, Smedegaard S, Sedgwick G, Lukas C, Hartmann-Petersen R, Lukas J, Choudhary C, Pocock R, Bekker-Jensen S, et al. DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. Nature Structural & Molecular Biology. 19: 1084-92. PMID 23042605 DOI: 10.1038/Nsmb.2395 |
0.567 |
|
| 2012 |
Oplustilova L, Wolanin K, Mistrik M, Korinkova G, Simkova D, Bouchal J, Lenobel R, Bartkova J, Lau A, O'Connor MJ, Lukas J, Bartek J. Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment Cell Cycle. 11: 3837-3850. PMID 22983061 DOI: 10.4161/Cc.22026 |
0.437 |
|
| 2012 |
Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, ... ... Lukas J, et al. TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell. 150: 697-709. PMID 22884692 DOI: 10.1016/J.Cell.2012.06.039 |
0.536 |
|
| 2012 |
Daugaard M, Baude A, Fugger K, Povlsen LK, Beck H, Sørensen CS, Petersen NH, Sorensen PH, Lukas C, Bartek J, Lukas J, Rohde M, Jäättelä M. LEDGF (p75) promotes DNA-end resection and homologous recombination. Nature Structural & Molecular Biology. 19: 803-10. PMID 22773103 DOI: 10.1038/Nsmb.2314 |
0.497 |
|
| 2012 |
Falck J, Forment JV, Coates J, Mistrik M, Lukas J, Bartek J, Jackson SP. CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination. Embo Reports. 13: 561-8. PMID 22565321 DOI: 10.1038/Embor.2012.58 |
0.575 |
|
| 2012 |
Poulsen M, Lukas C, Lukas J, Bekker-Jensen S, Mailand N. Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks. The Journal of Cell Biology. 197: 189-99. PMID 22492721 DOI: 10.1083/Jcb.201109100 |
0.536 |
|
| 2012 |
Moudry P, Lukas C, Macurek L, Hanzlikova H, Hodny Z, Lukas J, Bartek J. Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage. Cell Cycle (Georgetown, Tex.). 11: 1573-82. PMID 22456334 DOI: 10.4161/Cc.19978 |
0.563 |
|
| 2012 |
Jungmichel S, Clapperton JA, Lloyd J, Hari FJ, Spycher C, Pavic L, Li J, Haire LF, Bonalli M, Larsen DH, Lukas C, Lukas J, MacMillan D, Nielsen ML, Stucki M, et al. The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator. Nucleic Acids Research. 40: 3913-28. PMID 22234878 DOI: 10.1093/Nar/Gkr1300 |
0.41 |
|
| 2011 |
Lukas J, Lukas C, Bartek J. More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance Nature Cell Biology. 13: 1161-1169. PMID 21968989 DOI: 10.1038/Ncb2344 |
0.55 |
|
| 2011 |
Lukas J, Bartek J. Tethered genes get checked during replication. Cell. 146: 189-91. PMID 21784241 DOI: 10.1016/J.Cell.2011.06.046 |
0.396 |
|
| 2011 |
Bartek J, Lukas J. DNA repair: Cyclin D1 multitasks Nature. 474: 171-172. PMID 21654798 DOI: 10.1038/474171a |
0.389 |
|
| 2011 |
Devgan SS, Sanal O, Doil C, Nakamura K, Nahas SA, Pettijohn K, Bartek J, Lukas C, Lukas J, Gatti RA. Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia. Cell Death and Differentiation. 18: 1500-6. PMID 21394101 DOI: 10.1038/Cdd.2011.18 |
0.498 |
|
| 2011 |
Lukas C, Savic V, Bekker-Jensen S, Doil C, Neumann B, Pedersen RS, Grøfte M, Chan KL, Hickson ID, Bartek J, Lukas J. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nature Cell Biology. 13: 243-53. PMID 21317883 DOI: 10.1038/Ncb2201 |
0.523 |
|
| 2011 |
Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle (Georgetown, Tex.). 10: 457-68. PMID 21248468 DOI: 10.4161/Cc.10.3.14707 |
0.465 |
|
| 2011 |
Bartkova J, Moudry P, Hodny Z, Lukas J, Meyts ER, Bartek J. Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours. International Journal of Andrology. 34. PMID 20695923 DOI: 10.1111/J.1365-2605.2010.01096.X |
0.422 |
|
| 2010 |
Lukas J. The interface between the ubiquitin family and the DNA damage response Embo Reports. 11: 907-909. PMID 21072060 DOI: 10.1038/Embor.2010.180 |
0.516 |
|
| 2010 |
Larsen DH, Poinsignon C, Gudjonsson T, Dinant C, Payne MR, Hari FJ, Rendtlew Danielsen JM, Menard P, Sand JC, Stucki M, Lukas C, Bartek J, Andersen JS, Lukas J. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. The Journal of Cell Biology. 190: 731-40. PMID 20805324 DOI: 10.1083/Jcb.200912135 |
0.614 |
|
| 2010 |
Bennetzen MV, Larsen DH, Bunkenborg J, Bartek J, Lukas J, Andersen JS. Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Molecular & Cellular Proteomics : McP. 9: 1314-23. PMID 20164059 DOI: 10.1074/Mcp.M900616-Mcp200 |
0.49 |
|
| 2010 |
Bekker-Jensen S, Rendtlew Danielsen J, Fugger K, Gromova I, Nerstedt A, Lukas C, Bartek J, Lukas J, Mailand N. HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nature Cell Biology. 12: 80-6; sup pp 1-12. PMID 20023648 DOI: 10.1038/Ncb2008 |
0.561 |
|
| 2009 |
Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response. The Journal of Cell Biology. 186: 835-47. PMID 19797077 DOI: 10.1083/Jcb.200902150 |
0.575 |
|
| 2009 |
Fugger K, Mistrik M, Danielsen JR, Dinant C, Falck J, Bartek J, Lukas J, Mailand N. Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities. The Journal of Cell Biology. 186: 655-63. PMID 19736316 DOI: 10.1083/Jcb.200812138 |
0.582 |
|
| 2009 |
Mistrik M, Oplustilova L, Lukas J, Bartek J. Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis. Cell Cycle (Georgetown, Tex.). 8: 2592-9. PMID 19625777 DOI: 10.4161/Cc.8.16.9331 |
0.536 |
|
| 2009 |
Lukas J, Bartek J. DNA repair: New tales of an old tail Nature. 458: 581-583. PMID 19340068 DOI: 10.1038/458581A |
0.553 |
|
| 2009 |
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell. 136: 435-46. PMID 19203579 DOI: 10.1016/J.Cell.2008.12.041 |
0.513 |
|
| 2009 |
Carson CT, Orazio NI, Lee DV, Suh J, Bekker-Jensen S, Araujo FD, Lakdawala SS, Lilley CE, Bartek J, Lukas J, Weitzman MD. Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. The Embo Journal. 28: 652-62. PMID 19197236 DOI: 10.1038/Emboj.2009.15 |
0.363 |
|
| 2009 |
Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N. USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin. The Journal of Cell Biology. 184: 13-9. PMID 19124652 DOI: 10.1083/Jcb.200807137 |
0.486 |
|
| 2009 |
Rendtlew Danielsen JM, Larsen DH, Schou KB, Freire R, Falck J, Bartek J, Lukas J. HCLK2 is required for activity of the DNA damage response kinase ATR. The Journal of Biological Chemistry. 284: 4140-7. PMID 19097996 DOI: 10.1074/Jbc.M808174200 |
0.543 |
|
| 2008 |
Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, Mistrik M, Aittomäki K, Blomqvist C, Heikkilä P, Lukas J, Nevanlinna H, Bartek J. Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Molecular Oncology. 2: 296-316. PMID 19383352 DOI: 10.1016/J.Molonc.2008.09.007 |
0.419 |
|
| 2008 |
Bartek J, Hodny Z, Lukas J. Cytokine loops driving senescence. Nature Cell Biology. 10: 887-9. PMID 18670449 DOI: 10.1038/Ncb0808-887 |
0.335 |
|
| 2008 |
Lukas J, Bartek J. DNA damage: A histone-code mediator leaves the stage Nature Structural and Molecular Biology. 15: 430-432. PMID 18461044 DOI: 10.1038/Nsmb0508-430 |
0.504 |
|
| 2008 |
Melander F, Bekker-Jensen S, Falck J, Bartek J, Mailand N, Lukas J. Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. The Journal of Cell Biology. 181: 213-26. PMID 18411307 DOI: 10.1083/Jcb.200708210 |
0.479 |
|
| 2008 |
Tommiska J, Bartkova J, Heinonen M, Hautala L, Kilpivaara O, Eerola H, Aittomäki K, Hofstetter B, Lukas J, von Smitten K, Blomqvist C, Ristimäki A, Heikkilä P, Bartek J, Nevanlinna H. The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer. Oncogene. 27: 2501-6. PMID 17982490 DOI: 10.1038/Sj.Onc.1210885 |
0.43 |
|
| 2008 |
Keldsbo A, Rohde M, Larsen D, Lukas J, Jäättelä M. 9 Apaf-1 is required for proper ATR function in the DNA damage response Apmis. 116: 421-421. DOI: 10.1111/J.1600-0463.2008.00Abs1165_21.X |
0.499 |
|
| 2008 |
Bekker-Jensen S, Bartek J, Lukas J, Mailand N. 1 Ubiquitylation of histones at sites of DNA damage Apmis. 116: 418-419. DOI: 10.1111/J.1600-0463.2008.00Abs1165_15.X |
0.471 |
|
| 2008 |
Larsen DH, Poinsignon C, Rendtlew J, Bartek J, Lukas J. 65Involvement of the chromatin remodeling factors CHD4 in the DNA damage response Apmis. 116: 442-442. DOI: 10.1111/J.1600-0463.2008.001165_66.X |
0.49 |
|
| 2007 |
Groth A, Corpet A, Cook AJ, Roche D, Bartek J, Lukas J, Almouzni G. Regulation of replication fork progression through histone supply and demand. Science (New York, N.Y.). 318: 1928-31. PMID 18096807 DOI: 10.1126/Science.1148992 |
0.392 |
|
| 2007 |
Bartek J, Bartkova J, Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene. 26: 7773-7779. PMID 18066090 DOI: 10.1038/Sj.Onc.1210881 |
0.587 |
|
| 2007 |
Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell. 131: 887-900. PMID 18001824 DOI: 10.1016/J.Cell.2007.09.040 |
0.541 |
|
| 2007 |
Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP. Human CtIP promotes DNA end resection. Nature. 450: 509-14. PMID 17965729 DOI: 10.1038/Nature06337 |
0.557 |
|
| 2007 |
Löffler H, Bochtler T, Fritz B, Tews B, Ho AD, Lukas J, Bartek J, Krämer A. DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function. Cell Cycle (Georgetown, Tex.). 6: 2541-8. PMID 17726372 DOI: 10.4161/Cc.6.20.4810 |
0.586 |
|
| 2007 |
Bartek J, Lukas J, Bartkova J. DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'. Cell Cycle (Georgetown, Tex.). 6: 2344-7. PMID 17700066 DOI: 10.4161/Cc.6.19.4754 |
0.544 |
|
| 2007 |
Bartkova J, Meyts ER, Skakkebæk NE, Lukas J, Bartek J. DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy International Journal of Andrology. 30: 282-291. PMID 17573848 DOI: 10.1111/J.1365-2605.2007.00772.X |
0.557 |
|
| 2007 |
Bartkova J, Horejsí Z, Sehested M, Nesland JM, Meyts ER, Skakkebaek NE, Stucki M, Jackson S, Lukas J, Bartek J. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene. 26: 7414-7422. PMID 17546051 DOI: 10.1038/Sj.Onc.1210553 |
0.447 |
|
| 2007 |
Bekker-Jensen S, Fugger K, Danielsen JR, Gromova I, Sehested M, Celis J, Bartek J, Lukas J, Mailand N. Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. The Journal of Biological Chemistry. 282: 19638-43. PMID 17507382 DOI: 10.1074/Jbc.C700060200 |
0.603 |
|
| 2007 |
Bartek J, Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation Current Opinion in Cell Biology. 19: 238-245. PMID 17303408 DOI: 10.1016/J.Ceb.2007.02.009 |
0.572 |
|
| 2006 |
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, ... ... Lukas J, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 444: 633-7. PMID 17136093 DOI: 10.1038/Nature05268 |
0.567 |
|
| 2006 |
Löffler H, Rebacz B, Ho AD, Lukas J, Bartek J, Krämer A. Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events. Cell Cycle (Georgetown, Tex.). 5: 2543-7. PMID 17106257 DOI: 10.4161/Cc.5.21.3435 |
0.403 |
|
| 2006 |
Tort F, Bartkova J, Sehested M, Orntoft T, Lukas J, Bartek J. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Research. 66: 10258-63. PMID 17079443 DOI: 10.1158/0008-5472.Can-06-2178 |
0.51 |
|
| 2006 |
Syljuåsen RG, Jensen S, Bartek J, Lukas J. Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Research. 66: 10253-7. PMID 17079442 DOI: 10.1158/0008-5472.Can-06-2144 |
0.541 |
|
| 2006 |
Bartek J, Lukas J. Balancing life-or-death decisions Science. 314: 261-262. PMID 17038611 DOI: 10.1126/Science.1133758 |
0.461 |
|
| 2006 |
Mailand N, Bekker-Jensen S, Bartek J, Lukas J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Molecular Cell. 23: 307-18. PMID 16885021 DOI: 10.1016/J.Molcel.2006.06.016 |
0.521 |
|
| 2006 |
Liu S, Bekker-Jensen S, Mailand N, Lukas C, Bartek J, Lukas J. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Molecular and Cellular Biology. 26: 6056-64. PMID 16880517 DOI: 10.1128/Mcb.00492-06 |
0.567 |
|
| 2006 |
Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nature Cell Biology. 8: 870-6. PMID 16862143 DOI: 10.1038/Ncb1446 |
0.555 |
|
| 2006 |
Löffler H, Lukas J, Bartek J, Krämer A. Structure meets function--centrosomes, genome maintenance and the DNA damage response. Experimental Cell Research. 312: 2633-40. PMID 16854412 DOI: 10.1016/J.Yexcr.2006.06.008 |
0.579 |
|
| 2006 |
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. The Journal of Cell Biology. 173: 195-206. PMID 16618811 DOI: 10.1083/Jcb.200510130 |
0.598 |
|
| 2006 |
Lukas J, Bohr VA, Halazonetis TD. Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium. Dna Repair. 5: 591-601. PMID 16504601 DOI: 10.1016/J.Dnarep.2006.01.006 |
0.527 |
|
| 2006 |
Bartek J, Lukas J. The stress of finding NEMO Science. 311: 1110-1111. PMID 16497923 DOI: 10.1126/Science.1124540 |
0.469 |
|
| 2006 |
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nature Cell Biology. 8: 37-45. PMID 16327781 DOI: 10.1038/Ncb1337 |
0.578 |
|
| 2006 |
Löffler H, Rebacz B, Ho AD, Lukas J, Bartek J, Krämer A. P27. Deficient mitotic chromatin condensation in response to Chk1 inhibition is mediated by deregulated Cdc25B Ejc Supplements. 4: 36-37. DOI: 10.1016/J.Ejcsup.2006.04.087 |
0.351 |
|
| 2005 |
Bekker-Jensen S, Lukas C, Melander F, Bartek J, Lukas J. Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. The Journal of Cell Biology. 170: 201-11. PMID 16009723 DOI: 10.1083/Jcb.200503043 |
0.519 |
|
| 2005 |
Lukas C, Bartek J, Lukas J. Imaging of protein movement induced by chromosomal breakage: Tiny 'local' lesions pose great 'global' challenges Chromosoma. 114: 146-154. PMID 15988581 DOI: 10.1007/S00412-005-0011-Y |
0.506 |
|
| 2005 |
Bartkova J, Bakkenist CJ, Rajpert-De Meyts E, Skakkebaek NE, Sehested M, Lukas J, Kastan MB, Bartek J. ATM activation in normal human tissues and testicular cancer. Cell Cycle (Georgetown, Tex.). 4: 838-45. PMID 15846060 DOI: 10.4161/Cc.4.6.1742 |
0.532 |
|
| 2005 |
Syljuåsen RG, Sørensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Molecular and Cellular Biology. 25: 3553-62. PMID 15831461 DOI: 10.1128/Mcb.25.9.3553-3562.2005 |
0.568 |
|
| 2005 |
Bartkova J, Horejsí Z, Koed K, Krämer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Ørntoft T, Lukas J, Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 434: 864-70. PMID 15829956 DOI: 10.1038/Nature03482 |
0.569 |
|
| 2005 |
Groth A, Ray-Gallet D, Quivy JP, Lukas J, Bartek J, Almouzni G. Human Asf1 regulates the flow of S phase histones during replicational stress. Molecular Cell. 17: 301-11. PMID 15664198 DOI: 10.1016/J.Molcel.2004.12.018 |
0.42 |
|
| 2005 |
Agner J, Falck J, Lukas J, Bartek J. Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway. Experimental Cell Research. 302: 162-9. PMID 15561098 DOI: 10.1016/J.Yexcr.2004.08.035 |
0.524 |
|
| 2005 |
Kilpivaara O, Bartkova J, Eerola H, Syrjäkoski K, Vahteristo P, Lukas J, Blomqvist C, Holli K, Heikkilä P, Sauter G, Kallioniemi OP, Bartek J, Nevanlinna H. Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients. International Journal of Cancer. 113: 575-80. PMID 15472904 DOI: 10.1002/Ijc.20638 |
0.301 |
|
| 2004 |
Syljuåsen RG, Sørensen CS, Nylandsted J, Lukas C, Lukas J, Bartek J. Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation. Cancer Research. 64: 9035-40. PMID 15604269 DOI: 10.1158/0008-5472.Can-04-2434 |
0.438 |
|
| 2004 |
Krämer A, Lukas J, Bartek J. Checking out the centrosome. Cell Cycle (Georgetown, Tex.). 3: 1390-3. PMID 15483402 DOI: 10.4161/Cc.3.11.1252 |
0.465 |
|
| 2004 |
Bartek J, Lukas C, Lukas J. Checking on DNA damage in S phase Nature Reviews Molecular Cell Biology. 5: 792-804. PMID 15459660 DOI: 10.1038/Nrm1493 |
0.568 |
|
| 2004 |
Lukas J, Bartek J. Watching the DNA repair ensemble dance Cell. 118: 666-668. PMID 15369665 DOI: 10.1016/J.Cell.2004.09.006 |
0.503 |
|
| 2004 |
Staalesen V, Falck J, Geisler S, Bartkova J, Børresen-Dale AL, Lukas J, Lillehaug JR, Bartek J, Lønning PE. Alternative splicing and mutation status of CHEK2 in stage III breast cancer. Oncogene. 23: 8535-44. PMID 15361853 DOI: 10.1038/Sj.Onc.1207928 |
0.391 |
|
| 2004 |
Bartkova J, Guldberg P, Grønbaek K, Koed K, Primdahl H, Møller K, Lukas J, Ørntoft TF, Bartek J. Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer. Oncogene. 23: 8545-51. PMID 15361851 DOI: 10.1038/Sj.Onc.1207878 |
0.487 |
|
| 2004 |
Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nature Cell Biology. 6: 884-91. PMID 15311285 DOI: 10.1038/Ncb1165 |
0.422 |
|
| 2004 |
Lukas J, Lukas C, Bartek J. Mammalian cell cycle checkpoints: Signalling pathways and their organization in space and time Dna Repair. 3: 997-1007. PMID 15279786 DOI: 10.1016/J.Dnarep.2004.03.006 |
0.485 |
|
| 2004 |
Kilpivaara O, Vahteristo P, Falck J, Syrjäkoski K, Eerola H, Easton D, Bartkova J, Lukas J, Heikkilä P, Aittomäki K, Holli K, Blomqvist C, Kallioniemi OP, Bartek J, Nevanlinna H. CHEK2 variant I157T may be associated with increased breast cancer risk. International Journal of Cancer. 111: 543-7. PMID 15239132 DOI: 10.1002/Ijc.20299 |
0.366 |
|
| 2004 |
Latella L, Lukas J, Simone C, Puri PL, Bartek J. Differentiation-induced radioresistance in muscle cells. Molecular and Cellular Biology. 24: 6350-61. PMID 15226436 DOI: 10.1128/Mcb.24.14.6350-6361.2004 |
0.535 |
|
| 2004 |
Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J. Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention Embo Journal. 23: 2674-2683. PMID 15201865 DOI: 10.1038/Sj.Emboj.7600269 |
0.561 |
|
| 2004 |
Sørensen CS, Syljuåsen RG, Lukas J, Bartek J. ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle (Georgetown, Tex.). 3: 941-5. PMID 15190204 DOI: 10.4161/Cc.3.7.972 |
0.586 |
|
| 2004 |
Melixetian M, Ballabeni A, Masiero L, Gasparini P, Zamponi R, Bartek J, Lukas J, Helin K. Loss of Geminin induces rereplication in the presence of functional p53. The Journal of Cell Biology. 165: 473-82. PMID 15159417 DOI: 10.1083/Jcb.200403106 |
0.562 |
|
| 2004 |
Horejsí Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J, Bartek J. Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene. 23: 3122-7. PMID 15048089 DOI: 10.1038/Sj.Onc.1207447 |
0.518 |
|
| 2003 |
Löffler H, Syljuåsen RG, Bartkova J, Worm J, Lukas J, Bartek J. Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines. Oncogene. 22: 8063-71. PMID 14603247 DOI: 10.1038/Sj.Onc.1206976 |
0.434 |
|
| 2003 |
Celis JE, Gromov P, Gromova I, Moreira JM, Cabezón T, Ambartsumian N, Grigorian M, Lukanidin E, Thor Straten P, Guldberg P, Bartkova J, Bartek J, Lukas J, Lukas C, Lykkesfeldt A, et al. Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research. Molecular & Cellular Proteomics : McP. 2: 369-77. PMID 12832461 DOI: 10.1074/Mcp.R300007-Mcp200 |
0.307 |
|
| 2003 |
Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer Cancer Cell. 3: 421-429. PMID 12781359 DOI: 10.1016/S1535-6108(03)00110-7 |
0.514 |
|
| 2003 |
Bartkova J, Meyts ER, Skakkebæk NE, Lukas J, Bartek J. Deregulation of the G1/S-phase control in human testicular germ cell tumours. Apmis. 111: 252-266. PMID 12760379 DOI: 10.1034/J.1600-0463.2003.1110129.X |
0.445 |
|
| 2003 |
Bartkova J, Lukas C, Sørensen CS, Meyts ER, Skakkebaek NE, Lukas J, Bartek J. Deregulation of the RB pathway in human testicular germ cell tumours. The Journal of Pathology. 200: 149-156. PMID 12754735 DOI: 10.1002/Path.1353 |
0.395 |
|
| 2003 |
Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A Cancer Cell. 3: 247-258. PMID 12676583 DOI: 10.1016/S1535-6108(03)00048-5 |
0.441 |
|
| 2003 |
Groth A, Lukas J, Nigg EA, Silljé HHW, Wernstedt C, Bartek J, Hansen K. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. The Embo Journal. 22: 1676-1687. PMID 12660173 DOI: 10.1093/Emboj/Cdg151 |
0.581 |
|
| 2003 |
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage Nature Cell Biology. 5: 255-260. PMID 12598907 DOI: 10.1038/Ncb945 |
0.568 |
|
| 2003 |
Gatei M, Sloper K, Sörensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Journal of Biological Chemistry. 278: 14806-14811. PMID 12588868 DOI: 10.1074/Jbc.M210862200 |
0.526 |
|
| 2003 |
Bartek J, Lukas J. DNA repair: Damage alert Nature. 421: 486-488. PMID 12556872 DOI: 10.1038/421486A |
0.503 |
|
| 2002 |
Tedesco D, Lukas J, Reed SI. The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). Genes & Development. 16: 2946-57. PMID 12435635 DOI: 10.1101/Gad.1011202 |
0.368 |
|
| 2002 |
Mailand N, Podtelejnikov AV, Groth A, Mann M, Bartek J, Lukas J. Regulation of G2/M events by Cdc25A through phosphorylation‐dependent modulation of its stability The Embo Journal. 21: 5911-5920. PMID 12411508 DOI: 10.1093/Emboj/Cdf567 |
0.502 |
|
| 2002 |
Santoni-Rugiu E, Duro D, Farkas T, Mathiasen IS, Jäättelä M, Bartek J, Lukas J. E2F activity is essential for survival of Myc-overexpressing human cancer cells. Oncogene. 21: 6498-6509. PMID 12226753 DOI: 10.1038/Sj.Onc.1205828 |
0.389 |
|
| 2002 |
Farkas T, Hansen K, Holm K, Lukas J, Bartek J. Distinct Phosphorylation Events Regulate p130- and p107-mediated Repression of E2F-4 Journal of Biological Chemistry. 277: 26741-26752. PMID 12006580 DOI: 10.1074/Jbc.M200381200 |
0.374 |
|
| 2002 |
Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nature Cell Biology. 4: 358-66. PMID 11988738 DOI: 10.1038/Ncb785 |
0.377 |
|
| 2002 |
Mailand N, Lukas C, Kaiser BK, Jackson PK, Bartek J, Lukas J. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nature Cell Biology. 4: 317-22. PMID 11901424 DOI: 10.1038/Ncb777 |
0.412 |
|
| 2002 |
Falck J, Petrini JH, Williams BR, Lukas J, Bartek J. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nature Genetics. 30: 290-4. PMID 11850621 DOI: 10.1038/Ng845 |
0.601 |
|
| 2001 |
Bartek J, Lukas J. Mammalian G1- and S-phase checkpoints in response to DNA damage Current Opinion in Cell Biology. 13: 738-747. PMID 11698191 DOI: 10.1016/S0955-0674(00)00280-5 |
0.424 |
|
| 2001 |
Bartkova J, Falck J, Meyts ER, Skakkebæk NE, Lukas J, Bartek J. Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours. Oncogene. 20: 5897-5902. PMID 11593395 DOI: 10.1038/Sj.Onc.1204746 |
0.442 |
|
| 2001 |
Bartek J, Lukas J. Order from destruction Science. 294: 66-67. PMID 11588240 DOI: 10.1126/Science.1066237 |
0.357 |
|
| 2001 |
Falck J, Lukas C, Protopopova M, Lukas J, Selivanova G, Bartek J. Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. Oncogene. 20: 5503-5510. PMID 11571648 DOI: 10.1038/Sj.Onc.1204811 |
0.323 |
|
| 2001 |
Jensen SS, Madsen MW, Lukas J, Binderup L, Bartek J. Inhibitory Effects of 1α,25-Dihydroxyvitamin D3 on the G1–S Phase-Controlling Machinery Molecular Endocrinology. 15: 1370-1380. PMID 11463860 DOI: 10.1210/Mend.15.8.0673 |
0.32 |
|
| 2001 |
SØrensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J. A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression Molecular and Cellular Biology. 21: 3692-3703. PMID 11340163 DOI: 10.1128/Mcb.21.11.3692-3703.2001 |
0.426 |
|
| 2001 |
Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. 410: 842-847. PMID 11298456 DOI: 10.1038/35071124 |
0.598 |
|
| 2001 |
Bartek J, Lukas J. P27 destruction: Cks1 pulls the trigger Nature Cell Biology. 3. PMID 11283628 DOI: 10.1038/35070160 |
0.486 |
|
| 2001 |
Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M. Repression of p15INK4b expression by Myc through association with Miz-1. Nature Cell Biology. 3: 392-9. PMID 11283613 DOI: 10.1038/35070076 |
0.376 |
|
| 2001 |
Bartek J, Lukas J. Pathways governing G1/S transition and their response to DNA damage Febs Letters. 490: 117-122. PMID 11223026 DOI: 10.1016/S0014-5793(01)02114-7 |
0.51 |
|
| 2001 |
Hansen K, Farkas T, Lukas J, Holm K, Rönnstrand L, Bartek J. Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block The Embo Journal. 20: 422-432. PMID 11157749 DOI: 10.1093/Emboj/20.3.422 |
0.37 |
|
| 2000 |
Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J. Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis Molecular and Cellular Biology. 20: 7613-7623. PMID 11003657 DOI: 10.1128/Mcb.20.20.7613-7623.2000 |
0.572 |
|
| 2000 |
Thullberg M, Bartek J, Lukas J. Ubiquitin/proteasome-mediated degradation of p19(INK4d) determines its periodic expression during the cell cycle Oncogene. 19: 2870-2876. PMID 10851091 DOI: 10.1038/Sj.Onc.1203579 |
0.375 |
|
| 2000 |
Mailand N, Falck J, Lukas C, Syljuåsen RG, Welcker M, Bartek J, Lukas J. Rapid destruction of human Cdc25A in response to DNA damage. Science. 288: 1425-1429. PMID 10827953 DOI: 10.1126/Science.288.5470.1425 |
0.621 |
|
| 2000 |
Santoni-Rugiu E, Falck J, Mailand N, Bartek J, Lukas J. Involvement of Myc Activity in a G1/S-Promoting Mechanism Parallel to the pRb/E2F Pathway Molecular and Cellular Biology. 20: 3497-3509. PMID 10779339 DOI: 10.1128/Mcb.20.10.3497-3509.2000 |
0.516 |
|
| 2000 |
Hlobilkova A, Guldberg P, Thullberg M, Zeuthen J, Lukas J, Bartek J. Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity. Experimental Cell Research. 256: 571-577. PMID 10772829 DOI: 10.1006/Excr.2000.4867 |
0.388 |
|
| 2000 |
Thullberg M, Welcker M, Bartkova J, Kjerulff AA, Lukas J, H J, Bartek J. Monoclonal antibody probes for p21WAF1/CIP1 and the INK4 family of cyclin-dependent kinase inhibitors Hybridoma. 19: 63-72. PMID 10768842 DOI: 10.1089/027245700315806 |
0.335 |
|
| 2000 |
Thullberg M, Bartkova J, Khan S, Hansen K, Rönnstrand L, Lukas J, Strauss M, Bartek J. Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors Febs Letters. 470: 161-166. PMID 10734227 DOI: 10.1016/S0014-5793(00)01307-7 |
0.37 |
|
| 1999 |
Meraldi P, Lukas J, Fry AM, Bartek J, Nigg EA. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nature Cell Biology. 1: 88-93. PMID 10559879 DOI: 10.1038/10054 |
0.481 |
|
| 1999 |
Lukas C, Sørensen CS, Kramer E, Santoni-Rugiu E, Lindeneg C, Peters JM, Bartek J, Lukas J. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature. 401: 815-8. PMID 10548110 DOI: 10.1038/44611 |
0.447 |
|
| 1999 |
Lukas C, Jensen SS, Bartkova J, Lukas J, Bartek J. Immunochemical Analysis of the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6, Using a Series of Monoclonal Antibodies Hybridoma. 18: 225-234. PMID 10475236 DOI: 10.1089/027245799315871 |
0.379 |
|
| 1999 |
Lukas J, Sørensen CS, Lukas C, Santoni-Rugiu E, Bartek J. p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis. Oncogene. 18: 3930-3935. PMID 10435615 DOI: 10.1038/Sj.Onc.1202777 |
0.364 |
|
| 1999 |
Bartek J, Lukas J, Bartkova J. Perspective: defects in cell cycle control and cancer. The Journal of Pathology. 187: 95-99. PMID 10341710 DOI: 10.1002/(Sici)1096-9896(199901)187:1<95::Aid-Path249>3.0.Co;2-# |
0.387 |
|
| 1999 |
Hansen K, Lukas J, Holm K, Kjerulff AA, Bartek J. Dissecting functions of the retinoblastoma tumor suppressor and the related pocket proteins by integrating genetic, cell biology, and electrophoretic techniques. Electrophoresis. 20: 372-381. PMID 10197445 DOI: 10.1002/(Sici)1522-2683(19990201)20:2<372::Aid-Elps372>3.0.Co;2-R |
0.393 |
|
| 1999 |
Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K. Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its subcellular localization The Embo Journal. 18: 396-410. PMID 9889196 DOI: 10.1093/Emboj/18.2.396 |
0.463 |
|
| 1998 |
Bartkova J, Lukas J, Strauss M, Bartek J. Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation Oncogene. 17: 1027-1037. PMID 9747882 DOI: 10.1038/Sj.Onc.1202016 |
0.318 |
|
| 1998 |
Gjoerup O, Lukas J, Bartek J, Willumsen BM. Rac and Cdc42 Are Potent Stimulators of E2F-dependent Transcription Capable of Promoting Retinoblastoma Susceptibility Gene Product Hyperphosphorylation Journal of Biological Chemistry. 273: 18812-18818. PMID 9668055 DOI: 10.1074/Jbc.273.30.18812 |
0.429 |
|
| 1998 |
Depoortere F, Keymeulen AV, Lukas J, Costagliola S, Bartkova J, Dumont JE, Bartek J, Roger PP, Dremier S. A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes. Journal of Cell Biology. 140: 1427-1439. PMID 9508775 DOI: 10.1083/Jcb.140.6.1427 |
0.39 |
|
| 1997 |
Bartkova J, Lukas J, Bartek J. Aberrations of the G1- and G1/S-regulating genes in human cancer Progress in Cell Cycle Research. 3: 211-220. PMID 9552416 DOI: 10.1007/978-1-4615-5371-7_16 |
0.446 |
|
| 1997 |
Bartek J, Bartkova J, Lukas J. The retinoblastoma protein pathway in cell cycle control and cancer Experimental Cell Research. 237: 1-6. PMID 9417859 DOI: 10.1006/Excr.1997.3776 |
0.373 |
|
| 1997 |
Lukas J, Herzinger T, Hansen K, Moroni MC, Resnitzky D, Helin K, Reed SI, Bartek J. Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes & Development. 11: 1479-92. PMID 9192874 DOI: 10.1101/Gad.11.11.1479 |
0.385 |
|
| 1997 |
Sandig V, Brand K, Herwig S, Lukas J, Bartek J, Strauss M. Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nature Medicine. 3: 313-319. PMID 9055859 DOI: 10.1038/Nm0397-313 |
0.301 |
|
| 1996 |
Lukas J, Bartkova J, Bartek J. Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint Molecular and Cellular Biology. 16: 6917-6925. PMID 8943347 DOI: 10.1128/Mcb.16.12.6917 |
0.381 |
|
| 1996 |
Bartek J, Bartkova J, Lukas J. The retinoblastoma protein pathway and the restriction point Current Opinion in Cell Biology. 8: 805-814. PMID 8939678 DOI: 10.1016/S0955-0674(96)80081-0 |
0.486 |
|
| 1996 |
Lukas J, Petersen BO, Holm K, Bartek J, Helin K. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Molecular and Cellular Biology. 16: 1047-1057. PMID 8622649 DOI: 10.1128/Mcb.16.3.1047 |
0.384 |
|
| 1995 |
Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature. 375: 503-6. PMID 7777060 DOI: 10.1038/375503A0 |
0.41 |
|
| 1995 |
Lukas J, Bartkova J, Rohde M, Strauss M, Bartek J. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Molecular and Cellular Biology. 15: 2600-2611. PMID 7739541 DOI: 10.1128/Mcb.15.5.2600 |
0.392 |
|
| 1995 |
Aagaard L, Lukas J, Bartkova J, Kjerulff A, Strauss M, Bartek J. Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines. International Journal of Cancer. 61: 115-120. PMID 7705923 DOI: 10.1002/Ijc.2910610120 |
0.455 |
|
| 1995 |
Strauss M, Lukas J, Bartek J. Unrestricted cell cycling and cancer Nature Medicine. 1: 1245-1246. PMID 7489399 DOI: 10.1038/Nm1295-1245 |
0.373 |
|
| 1995 |
Steiner P, Philipp A, Lukas J, Godden-Kent D, Pagano M, Mittnacht S, Bartek J, Eilers M. Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. The Embo Journal. 14: 4814-4826. DOI: 10.1002/J.1460-2075.1995.Tb00163.X |
0.395 |
|
| 1994 |
Bartkova J, Lukas J, Strauss M, Bartek J. Cell cycle‐related variation and tissue‐restricted expression of human cyclin D1 protein The Journal of Pathology. 172: 237-245. PMID 8195927 DOI: 10.1002/Path.1711720303 |
0.337 |
|
| 1994 |
Lukas J, Müller H, Bartkova J, Spitkovsky D, Kjerulff AA, Jansen-Dürr P, Strauss M, Bartek J. DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. Journal of Cell Biology. 125: 625-638. PMID 8175885 DOI: 10.1083/Jcb.125.3.625 |
0.398 |
|
| 1994 |
Bartkova J, Lukas J, Müller H, Lützhøt D, Strauss M, Bartek J. Cyclin D1 protein expression and function in human breast cancer. International Journal of Cancer. 57: 353-361. PMID 8168995 DOI: 10.1002/Ijc.2910570311 |
0.378 |
|
| 1994 |
Lukas J, Bartek J, Strauss M. Efficient transfer of antibodies into mammalian cells by electroporation Journal of Immunological Methods. 170: 255-259. PMID 8158003 DOI: 10.1016/0022-1759(94)90400-6 |
0.321 |
|
| 1994 |
Spitkovsky D, Steiner P, Lukas J, Lees E, Pagano M, Schulze A, Joswig S, Picard D, Tommasino M, Eilers M, Jansen-Dürr P. Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation Journal of Virology. 68: 2206-2214. PMID 8139005 DOI: 10.1128/Jvi.68.4.2206-2214.1994 |
0.349 |
|
| 1994 |
Bartkova J, Lukas J, Strauss M, Bartek J. The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas. International Journal of Cancer. 58: 568-573. PMID 8056453 DOI: 10.1002/Ijc.2910580420 |
0.376 |
|
| 1993 |
Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes & Development. 7: 812-821. PMID 8491378 DOI: 10.1101/Gad.7.5.812 |
0.369 |
|
| 1993 |
Bartkova J, Bartek J, Vojtesek B, Lukas J, Rejthar A, Kovarik J, Millis RR, Lane DP, Barnes DM. Immunochemical analysis of the p53 oncoprotein in matched primary and metastatic human tumours. European Journal of Cancer (Oxford, England : 1990). 881-6. PMID 8484983 DOI: 10.1016/S0959-8049(05)80431-9 |
0.305 |
|
| 1993 |
Pagano M, Pepperkok R, Lukas J, Baldin V, Ansorge W, Bartek J, Draetta G. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts Journal of Cell Biology. 121: 101-111. PMID 8458862 DOI: 10.1083/Jcb.121.1.101 |
0.449 |
|
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