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Timothy Hla, Ph.D., M.D. (honoris causa) - Publications

Affiliations: 
1988-1996 Molecular Biology American Red Cross Holland Labs 
 1996-2009 Cell Biology University of Connecticut School of Medicine, Farmington, CT, United States 
 2009-2016 Pathology Weill Cornell Medical College, New York, NY, United States 
 2016- Vascular Biology Program/ Surgery Boston Children's Hospital/ Harvard Medical School 
Area:
Vascular system, bioactive lipids, sphingosine 1-phosphate, cyclooxygenase
Website:
https://projects.iq.harvard.edu/hlalab
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256 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lee MJ, Thangada S, Liu CH, Thompson BD, Hla T. Withdrawal: Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. The Journal of Biological Chemistry. 300: 107597. PMID 39096771 DOI: 10.1016/j.jbc.2024.107597  0.797
2024 Burg N, Malpass R, Alex L, Tran M, Englebrecht E, Kuo A, Pannelini T, Minett M, Athukorala K, Worgall T, Faust HJ, Goodman S, Mehta B, Brenner M, Vestweber D, ... ... Hla T, et al. Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis. Jci Insight. 9. PMID 38855867 DOI: 10.1172/jci.insight.171467  0.373
2024 Lin YC, Swendeman S, Moreira IS, Ghosh A, Kuo A, Rosário-Ferreira N, Guo S, Culbertson A, Levesque MV, Cartier A, Seno T, Schmaier A, Galvani S, Inoue A, Parikh SM, ... ... Hla T, et al. Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation. Science Signaling. 17: eadg9256. PMID 38377179 DOI: 10.1126/scisignal.adg9256  0.714
2023 Niaudet C, Jung B, Kuo A, Swendeman S, Bull E, Seno T, Crocker R, Fu Z, Smith LEH, Hla T. Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization. Embo Molecular Medicine. e16645. PMID 36912000 DOI: 10.15252/emmm.202216645  0.632
2022 Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LEH, Proia RL, Hla T. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. Elife. 11. PMID 36197001 DOI: 10.7554/eLife.78861  0.577
2022 Levesque MV, Hla T. Signal Transduction and Gene Regulation in the Endothelium. Cold Spring Harbor Perspectives in Medicine. PMID 35667710 DOI: 10.1101/cshperspect.a041153  0.341
2022 Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, Dannenberg AJ. Retraction: Obesity Is Associated With Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland. Cancer Prevention Research (Philadelphia, Pa.). 15: 413. PMID 35652231 DOI: 10.1158/1940-6207.CAPR-22-0202  0.658
2022 Burg N, Salmon JE, Hla T. Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases. Nature Reviews. Rheumatology. PMID 35508810 DOI: 10.1038/s41584-022-00784-6  0.311
2021 Del Gaudio I, Rubinelli L, Sasset L, Wadsack C, Hla T, Di Lorenzo A. Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate. Journal of the American Heart Association. 10: e021261. PMID 34240614 DOI: 10.1161/JAHA.121.021261  0.358
2021 Del Gaudio I, Rubinelli L, Sasset L, Wadsack C, Hla T, Di Lorenzo A. Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate. Journal of the American Heart Association. 10: e021261. PMID 34240614 DOI: 10.1161/JAHA.121.021261  0.358
2021 Mao Y, Kleinjan ML, Jilishitz I, Swaminathan B, Obinata H, Komarova YA, Bayless KJ, Hla T, Kitajewski JK. CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function. Science Signaling. 14. PMID 33879602 DOI: 10.1126/scisignal.abc0425  0.764
2020 Nitzsche A, Poittevin M, Benarab A, Bonnin P, Faraco G, Uchida H, Favre J, Garcia-Bonilla L, Garcia MC, Leger PP, Therond P, Mathivet T, Autret G, Baudrie V, Couty L, ... ... Hla T, et al. Endothelial S1P Signaling Counteracts Infarct Expansion in Ischemic Stroke. Circulation Research. PMID 33301355 DOI: 10.1161/CIRCRESAHA.120.316711  0.599
2020 Ding BS, Yang D, Swendeman SL, Christoffersen C, Nielsen LB, Friedman SL, Powell CA, Hla T, Cao Z. Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. Developmental Cell. PMID 32544390 DOI: 10.1016/J.Devcel.2020.05.024  0.395
2020 Geng X, Yanagida K, Akwii RG, Choi D, Chen L, Ho Y, Cha B, Mahamud MR, Berman de Ruiz K, Ichise H, Chen H, Wythe J, Mikelis CM, Hla T, Srinivasan RS. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. Jci Insight. PMID 32544090 DOI: 10.1172/Jci.Insight.137652  0.445
2020 Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, ... Hla T, et al. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 9. PMID 32091396 DOI: 10.7554/Elife.52690  0.496
2020 Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, Swendeman S, Liu CH, Levesque MV, Kuo A, Fu Z, Smith LEH, Betsholtz C, Hla T. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Developmental Cell. PMID 32059774 DOI: 10.1016/J.Devcel.2020.01.016  0.735
2020 Cartier A, Leigh T, Liu CH, Hla T. Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 31988136 DOI: 10.1073/Pnas.1906246117  0.615
2020 Pandey S, Banks KM, Kumar R, Kuo A, Wen D, Hla T, Evans T. Sphingosine Kinases Protect Murine ESCs from Sphingosine-induced Cell Cycle Arrest. Stem Cells (Dayton, Ohio). PMID 31916656 DOI: 10.1002/Stem.3145  0.459
2020 Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. Withdrawal: EP and EP receptors regulate aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange. The Journal of Biological Chemistry. 295: 295. PMID 31900377 DOI: 10.1074/jbc.W119.012140  0.491
2019 Poganik JR, Long MJC, Disare MT, Liu X, Chang SH, Hla T, Aye Y. Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901930R. PMID 31665914 DOI: 10.1096/Fj.201901930R  0.535
2019 Cartier A, Hla T. Sphingosine 1-phosphate: Lipid signaling in pathology and therapy. Science (New York, N.Y.). 366. PMID 31624181 DOI: 10.1126/Science.Aar5551  0.449
2019 Singh RK, Haka AS, Asmal A, Barbosa-Lorenzi VC, Grosheva I, Chin HF, Xiong Y, Hla T, Maxfield FR. TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119313200. PMID 31597445 DOI: 10.1161/Atvbaha.119.313200  0.643
2019 Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Sato K, Izumi T, Hla T. Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice. Journal of Lipid Research. PMID 31462513 DOI: 10.1194/Jlr.Ra119000277  0.831
2019 Tsai HC, Nguyen K, Hashemi E, Engleman E, Hla T, Han MH. Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation. Journal of Autoimmunity. PMID 31202617 DOI: 10.1016/J.Jaut.2019.06.001  0.483
2019 Inoue T, Kohno M, Nagahara H, Murakami K, Sagawa T, Kasahara A, Kaneshita S, Kida T, Fujioka K, Wada M, Nakada H, Hla T, Kawahito Y. Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production. Plos One. 14: e0218090. PMID 31173610 DOI: 10.1371/Journal.Pone.0218090  0.612
2019 Hisano Y, Kono M, Cartier A, Engelbrecht E, Kano K, Kawakami K, Xiong Y, Piao W, Galvani S, Yanagida K, Kuo A, Ono Y, Ishida S, Aoki J, Proia RL, ... ... Hla T, et al. Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes. The Journal of Experimental Medicine. PMID 31147448 DOI: 10.1084/Jem.20181895  0.712
2019 Obinata H, Hla T. Sphingosine 1-phosphate and inflammation. International Immunology. PMID 31049553 DOI: 10.1093/Intimm/Dxz037  0.766
2019 Shi X, Wang W, Li J, Wang T, Lin Y, Huang S, Kuver A, Chen C, Hla T, Li X, Dai K. Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells. Biochimica Et Biophysica Acta. General Subjects. PMID 30954526 DOI: 10.1016/J.Bbagen.2019.04.001  0.438
2019 Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X. Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology. 10: 404. PMID 30941120 DOI: 10.3389/Fimmu.2019.00404  0.689
2019 Xiong Y, Piao W, Brinkman CC, Li L, Kulinski JM, Olivera A, Cartier A, Hla T, Hippen KL, Blazar BR, Schwab SR, Bromberg JS. CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration. Science Immunology. 4. PMID 30877143 DOI: 10.1126/Sciimmunol.Aav1263  0.428
2019 Blaho V, Chun J, Frantz A, Hla T, Jones D, Jonnalagadda D, Kihara Y, Mizuno H, Moolenaar W, Mpamhanga C, Spiegel S, Tan V, Yung YC. Lysophospholipid (LPA) receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f36/2019.4  0.733
2018 Swendeman SL, Hla T. Lipid Mediators, M2 Macrophages, and Pathological Neovascularization. Trends in Molecular Medicine. PMID 30448396 DOI: 10.1016/J.Molmed.2018.10.003  0.422
2018 Montrose DC, Zhou XK, McNally EM, Sue E, Wang H, Nishiguchi R, Verma A, Elemento O, Simpson KW, Yang P, Hla T, Dannenberg AJ. Colonoscopic-guided pinch biopsies in mice: A useful model for evaluating the roles of host and luminal factors in colonic inflammation. The American Journal of Pathology. PMID 30273600 DOI: 10.1016/J.Ajpath.2018.08.016  0.356
2018 Hisano Y, Hla T. Bioactive lysolipids in cancer and angiogenesis. Pharmacology & Therapeutics. PMID 30048709 DOI: 10.1016/J.Pharmthera.2018.07.006  0.461
2018 Burg N, Swendeman S, Worgall S, Hla T, Salmon JE. Sphingosine -1 Phosphate Receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29781582 DOI: 10.1002/Art.40558  0.477
2018 Ghosh M, Thangada S, Dasgupta O, Khanna KM, Yamase HT, Kashgarian M, Hla T, Shapiro LH, Ferrer FA. Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction. Plos One. 13: e0194053. PMID 29518138 DOI: 10.1371/Journal.Pone.0194053  0.789
2017 Kono M, Conlon EG, Lux SY, Yanagida K, Hla T, Proia RL. Bioluminescence imaging of G protein-coupled receptor activation in living mice. Nature Communications. 8: 1163. PMID 29079828 DOI: 10.1038/S41467-017-01340-7  0.431
2017 Mendelson K, Pandey S, Hisano Y, Carellini F, Das B, Hla T, Evans T. The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine Levels during zebrafish embryogenesis. Elife. 6. PMID 28956531 DOI: 10.7554/Elife.21992  0.387
2017 Singh RK, Haka AS, Brumfield A, Grosheva I, Bhardwaj P, Chin HF, Xiong Y, Hla T, Maxfield FR. Ceramide Activation of RhoA/Rho Kinase Impairs Actin Polymerization during Aggregated LDL Catabolism. Journal of Lipid Research. PMID 28814641 DOI: 10.1194/Jlr.M076398  0.623
2017 Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, ... ... Hla T, et al. An engineered S1P chaperone attenuates hypertension and ischemic injury. Science Signaling. 10. PMID 28811382 DOI: 10.1126/Scisignal.Aal2722  0.83
2017 Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, et al. Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. Elife. 6. PMID 28654421 DOI: 10.7554/eLife.29849  0.556
2017 Cantalupo A, Gargiulo A, Dautaj E, Liu C, Zhang Y, Hla T, Di Lorenzo A. S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. Hypertension (Dallas, Tex. : 1979). PMID 28607130 DOI: 10.1161/Hypertensionaha.117.09088  0.685
2017 Galvani S, Hla T. Quality Versus Quantity: Making HDL Great Again. Arteriosclerosis, Thrombosis, and Vascular Biology. 37: 1018-1019. PMID 28539490 DOI: 10.1161/Atvbaha.117.309441  0.633
2017 Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, Chaluvadi VS, Dustin ML, Hla T, Elemento O, Chipuk JE, Schwab SR. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature. PMID 28538737 DOI: 10.1038/Nature22352  0.37
2017 Yanagida K, Liu CH, Faraco G, Galvani S, Smith HK, Burg N, Anrather J, Sanchez T, Iadecola C, Hla T. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396408 DOI: 10.1073/Pnas.1618659114  0.815
2016 Ding BS, Liu CH, Sun Y, Chen Y, Swendeman SL, Jung B, Chavez D, Cao Z, Christoffersen C, Nielsen LB, Schwab SR, Rafii S, Hla T. HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver. Jci Insight. 1: e87058. PMID 28018969 DOI: 10.1172/Jci.Insight.87058  0.731
2016 Yanagida K, Hla T. Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. Annual Review of Physiology. PMID 27813829 DOI: 10.1146/Annurev-Physiol-021014-071635  0.43
2016 Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, ... ... Hla T, et al. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circulation Research. PMID 27582371 DOI: 10.1161/Circresaha.116.308929  0.673
2016 Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL, Hla T. Sphingosine kinases are not required for inflammatory responses in macrophages. The Journal of Biological Chemistry. 291: 11465. PMID 27226645 DOI: 10.1074/Jbc.A113.483750  0.586
2016 Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C. Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26956418 DOI: 10.1096/Fj.201500064  0.801
2015 Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekra W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, et al. TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase-1. Elife. 4. PMID 26701909 DOI: 10.7554/Elife.10592  0.622
2015 Cantalupo A, Zhang Y, Kothiya M, Galvani S, Obinata H, Bucci M, Giordano FJ, Jiang XC, Hla T, Di Lorenzo A. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nature Medicine. 21: 1028-37. PMID 26301690 DOI: 10.1038/Nm.3934  0.805
2015 Galvani S, Sanson M, Blaho VA, Swendeman SL, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T. HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. Science Signaling. 8: ra79. PMID 26268607 DOI: 10.1126/Scisignal.Aaa2581  0.854
2015 Li MH, Swenson R, Harel M, Jana S, Stolarzewicz E, Hla T, Shapiro LH, Ferrer F. Antitumor activity of a novel S1P2 antagonist, AB1, in neuroblastoma. The Journal of Pharmacology and Experimental Therapeutics. PMID 26105954 DOI: 10.1124/Jpet.115.224519  0.646
2015 Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, Hla T. HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. Nature. 523: 342-6. PMID 26053123 DOI: 10.1038/Nature14462  0.824
2015 Mendelson K, Lan Y, Hla T, Evans T. Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 25997406 DOI: 10.1002/Dvdy.24288  0.475
2015 Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. The Journal of Clinical Investigation. 125: 1379-87. PMID 25831442 DOI: 10.1172/Jci76369  0.474
2015 Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, et al. Author response: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 Elife. DOI: 10.7554/Elife.10592.018  0.597
2015 Galvani S, Sanson M, Blaho VA, Swendeman SL, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T. Erratum: HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P to limit vascular inflammation (Science Signaling) Science Signaling. 8. DOI: 10.1126/Scisignal.Aad6067  0.753
2015 Hla T, Galvani S, VanHook AM. Science signaling podcast: 11 August 2015 Science Signaling. 8. DOI: 10.1126/Scisignal.Aad1081  0.726
2015 Galvani S, Sanson M, Blaho VA, Swendeman SL, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T. HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation Science Signaling. 8. DOI: 10.1126/scisignal.aaa2581  0.84
2015 Cantalupo A, Zhang Y, Kothiya M, Galvani S, Obinata H, Bucci M, Giordano FJ, Jiang XC, Hla T, Di Lorenzo A. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure Nature Medicine. DOI: 10.1038/nm.3934  0.767
2014 Lu YC, Chang SH, Hafner M, Li X, Tuschl T, Elemento O, Hla T. ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. Cell Reports. 9: 2330-43. PMID 25533351 DOI: 10.1016/J.Celrep.2014.11.030  0.497
2014 Camm J, Hla T, Bakshi R, Brinkmann V. Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. American Heart Journal. 168: 632-44. PMID 25440790 DOI: 10.1016/J.Ahj.2014.06.028  0.333
2014 Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 111: 18309-14. PMID 25422430 DOI: 10.1073/Pnas.1412172111  0.567
2014 Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T. Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions. Journal of Lipid Research. 55: 2665-75. PMID 25293589 DOI: 10.1194/Jlr.P054163  0.728
2014 Xiong Y, Yang P, Proia RL, Hla T. Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. The Journal of Clinical Investigation. 124: 4823-8. PMID 25250575 DOI: 10.1172/Jci77685  0.698
2014 Murakami K, Kohno M, Kadoya M, Nagahara H, Fujii W, Seno T, Yamamoto A, Oda R, Fujiwara H, Kubo T, Morita S, Nakada H, Hla T, Kawahito Y. Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. Plos One. 9: e106792. PMID 25198418 DOI: 10.1371/Journal.Pone.0106792  0.611
2014 Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A. The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. Cell Reports. 8: 1497-508. PMID 25176650 DOI: 10.1016/J.Celrep.2014.07.059  0.361
2014 Li MH, Harel M, Hla T, Ferrer F. Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. Journal of Pediatric Surgery. 49: 1286-91. PMID 25092091 DOI: 10.1016/J.Jpedsurg.2014.04.001  0.607
2014 Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Research. 74: 5322-35. PMID 25085247 DOI: 10.1158/0008-5472.Can-14-0726  0.547
2014 Xiong Y, Hla T. S1P control of endothelial integrity. Current Topics in Microbiology and Immunology. 378: 85-105. PMID 24728594 DOI: 10.1007/978-3-319-05879-5_4  0.692
2014 Chang SH, Hla T. Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis. Current Opinion in Hematology. 21: 235-40. PMID 24714527 DOI: 10.1097/Moh.0000000000000040  0.544
2014 Thangada S, Shapiro LH, Silva C, Yamase H, Hla T, Ferrer FA. Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. The Journal of Urology. 191: 1508-16. PMID 24679864 DOI: 10.1016/J.Juro.2013.10.072  0.767
2014 Garris CS, Blaho VA, Hla T, Han MH. Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond. Immunology. 142: 347-53. PMID 24597601 DOI: 10.1111/Imm.12272  0.752
2014 Blaho VA, Hla T. An update on the biology of sphingosine 1-phosphate receptors. Journal of Lipid Research. 55: 1596-1608. PMID 24459205 DOI: 10.1194/Jlr.R046300  0.778
2014 Li X, Lu YC, Dai K, Torregroza I, Hla T, Evans T. Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. Blood. 123: 1384-92. PMID 24425803 DOI: 10.1182/Blood-2013-09-526962  0.331
2014 Mendelson K, Evans T, Hla T. Sphingosine 1-phosphate signalling. Development (Cambridge, England). 141: 5-9. PMID 24346695 DOI: 10.1242/Dev.094805  0.511
2014 Blanc V, Klos CL, Giammanco A, Montenegro G, Xie Y, Kennedy S, Luo J, Chang S, Nalbantoglu I, Hla T, Dharmarajan S, Davidson N. 294 Conditional Intestine-Specific HuR Deletion (HuR-IKO) Modulates Distinct Wnt-Dependent and Independent Pathways of Proliferation and Apoptosis With No Effect on Ileal ASBT Expression or Bile Acid Metabolism Gastroenterology. 146: S-70. DOI: 10.1016/S0016-5085(14)60253-5  0.517
2013 Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL, Hla T. Sphingosine kinases are not required for inflammatory responses in macrophages. The Journal of Biological Chemistry. 288: 32563-73. PMID 24081141 DOI: 10.1074/Jbc.M113.483750  0.65
2013 Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, ... Hla T, et al. Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nature Immunology. 14: 1166-72. PMID 24076635 DOI: 10.1038/Ni.2730  0.762
2013 Li MH, Hla T, Ferrer F. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatric Blood & Cancer. 60: 1418-23. PMID 23704073 DOI: 10.1002/Pbc.24564  0.603
2013 Howe LR, Subbaramaiah K, Kent CV, Zhou XK, Chang SH, Hla T, Jakobsson PJ, Hudis CA, Dannenberg AJ. Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis. Prostaglandins & Other Lipid Mediators. 106: 99-105. PMID 23624019 DOI: 10.1016/J.Prostaglandins.2013.04.002  0.532
2013 Montrose DC, Scherl EJ, Bosworth BP, Zhou XK, Jung B, Dannenberg AJ, Hla T. S1P₁ localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity. Journal of Lipid Research. 54: 843-51. PMID 23296878 DOI: 10.1194/Jlr.M034108  0.658
2013 Mendelson K, Zygmunt T, Torres-Vázquez J, Evans T, Hla T. Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning. The Journal of Biological Chemistry. 288: 2143-56. PMID 23229546 DOI: 10.1074/Jbc.M112.427344  0.528
2013 Chang SH, Lu YC, Li X, Hsieh WY, Xiong Y, Ghosh M, Evans T, Elemento O, Hla T. Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis. The Journal of Biological Chemistry. 288: 4908-21. PMID 23223443 DOI: 10.1074/Jbc.M112.423871  0.758
2013 Montenegro G, Giammanco A, Blanc V, Kennedy S, Luo J, Chang S, Nalbantoglu I, Hla T, Davidson NO. Tu1732 Conditional Intestinal-Epithelial Specific HuR Deletion Modifies Murine Intestinal Tumorigenesis Gastroenterology. 144: S-833. DOI: 10.1016/S0016-5085(13)63096-6  0.547
2013 Giammanco A, Blanc V, Montenegro G, Kennedy S, Luo J, Chang S, Nalbantoglu I, Hla T, Davidson NO. 230 Conditional Intestine-Specific HuR Deletion (HuR-Iko) Modifies Epithelial Growth, Response to Injury and Tumorigenesis Gastroenterology. 144: S-50. DOI: 10.1016/S0016-5085(13)60176-6  0.47
2013 Jung B, Hla T. Sphingosine 1-Phosphate (S1P) Receptors Lysophospholipid Receptors: Signaling and Biochemistry. 41-60. DOI: 10.1002/9781118531426.ch2  0.329
2012 Hla T, Galvani S, Rafii S, Nachman R. S1P and the birth of platelets. The Journal of Experimental Medicine. 209: 2137-40. PMID 23166370 DOI: 10.1084/Jem.20122284  0.727
2012 Torregroza I, Holtzinger A, Mendelson K, Liu TC, Hla T, Evans T. Regulation of a vascular plexus by gata4 is mediated in zebrafish through the chemokine sdf1a. Plos One. 7: e46844. PMID 23056483 DOI: 10.1371/Journal.Pone.0046844  0.386
2012 Obinata H, Hla T. Fine-tuning S1P therapeutics. Chemistry & Biology. 19: 1080-2. PMID 22999874 DOI: 10.1016/J.Chembiol.2012.09.002  0.72
2012 Hla T, Dannenberg AJ. Sphingolipid signaling in metabolic disorders. Cell Metabolism. 16: 420-34. PMID 22982021 DOI: 10.1016/J.Cmet.2012.06.017  0.311
2012 Jung B, Obinata H, Galvani S, Mendelson K, Ding BS, Skoura A, Kinzel B, Brinkmann V, Rafii S, Evans T, Hla T. Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Developmental Cell. 23: 600-10. PMID 22975328 DOI: 10.1016/J.Devcel.2012.07.015  0.83
2012 Obinata H, Hla T. Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation. Methods in Molecular Biology (Clifton, N.J.). 874: 69-76. PMID 22528440 DOI: 10.1007/978-1-61779-800-9_6  0.769
2012 Takeshita H, Kitano M, Iwasaki T, Kitano S, Tsunemi S, Sato C, Sekiguchi M, Azuma N, Miyazawa K, Hla T, Sano H. Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis. Biochemical and Biophysical Research Communications. 419: 154-9. PMID 22326262 DOI: 10.1016/J.Bbrc.2012.01.103  0.447
2012 Moolenaar WH, Hla T. SnapShot: Bioactive lysophospholipids. Cell. 148: 378-378.e2. PMID 22265422 DOI: 10.1016/J.Cell.2012.01.013  0.468
2012 Obinata H, Hla T. Sphingosine 1-phosphate in coagulation and inflammation. Seminars in Immunopathology. 34: 73-91. PMID 21805322 DOI: 10.1007/S00281-011-0287-3  0.761
2012 Hla T. Sphingosine 1-phosphate Access Science. DOI: 10.1036/1097-8542.900158  0.359
2012 Li M, Hla T, Ferrer F. 837 INDUCTION OF MONOCYTE CHEMOATTRACTANT PROTEIN 1 BY SPHINGOSINE-1-PHOSPHATE IN NEUROBLASTOMA Journal of Urology. 187. DOI: 10.1016/J.Juro.2012.02.928  0.554
2012 Thangada S, Hla T, Grundy P, Ferrer F. 150 CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AND SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR 1 AND 2 LEVELS ARE ALTERED IN WILM'S TUMOR Journal of Urology. 187. DOI: 10.1016/J.Juro.2012.02.200  0.787
2011 Blaho VA, Hla T. Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chemical Reviews. 111: 6299-320. PMID 21939239 DOI: 10.1021/Cr200273U  0.773
2011 Chang SH, Hla T. Gene regulation by RNA binding proteins and microRNAs in angiogenesis. Trends in Molecular Medicine. 17: 650-8. PMID 21802991 DOI: 10.1016/J.Molmed.2011.06.008  0.508
2011 Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proceedings of the National Academy of Sciences of the United States of America. 108: 9613-8. PMID 21606363 DOI: 10.1073/Pnas.1103187108  0.825
2011 Li MH, Hla T, Ferrer F. Sphingolipid modulation of angiogenic factor expression in neuroblastoma. Cancer Prevention Research (Philadelphia, Pa.). 4: 1325-32. PMID 21576349 DOI: 10.1158/1940-6207.Capr-11-0017  0.67
2011 Oo ML, Chang SH, Thangada S, Wu MT, Rezaul K, Blaho V, Hwang SI, Han DK, Hla T. Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice. The Journal of Clinical Investigation. 121: 2290-300. PMID 21555855 DOI: 10.1172/Jci45403  0.837
2011 Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, Dannenberg AJ. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prevention Research (Philadelphia, Pa.). 4: 329-46. PMID 21372033 DOI: 10.1158/1940-6207.Capr-10-0381  0.701
2011 Hla T, Brinkmann V. Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. Neurology. 76: S3-8. PMID 21339489 DOI: 10.1212/Wnl.0B013E31820D5Ec1  0.405
2011 Skoura A, Michaud J, Im DS, Thangada S, Xiong Y, Smith JD, Hla T. Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 81-5. PMID 20947824 DOI: 10.1161/Atvbaha.110.213496  0.818
2010 Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 62: 579-87. PMID 21079037 DOI: 10.1124/Pr.110.003111  0.464
2010 Thangada S, Khanna KM, Blaho VA, Oo ML, Im DS, Guo C, Lefrancois L, Hla T. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. The Journal of Experimental Medicine. 207: 1475-83. PMID 20584883 DOI: 10.1084/Jem.20091343  0.839
2010 Habrukowich C, Han DK, Le A, Rezaul K, Pan W, Ghosh M, Li Z, Dodge-Kafka K, Jiang X, Bittman R, Hla T. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. The Journal of Biological Chemistry. 285: 26825-31. PMID 20558741 DOI: 10.1074/Jbc.M110.147058  0.81
2010 Michaud J, Im DS, Hla T. Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. Journal of Immunology (Baltimore, Md. : 1950). 184: 1475-83. PMID 20042570 DOI: 10.4049/Jimmunol.0901586  0.703
2010 Hla T, Oo ML. Ramping up RANTES in the acute response to arterial injury. The Journal of Clinical Investigation. 120: 90-2. PMID 20038805 DOI: 10.1172/Jci41738  0.313
2009 Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, Hemmes A, Ristimaki A, Guo C, Furneaux H, Hla T. Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. The Journal of Clinical Investigation. 119: 3530-43. PMID 19884656 DOI: 10.1172/Jci38263  0.773
2009 ter Braak M, Danneberg K, Lichte K, Liphardt K, Ktistakis NT, Pitson SM, Hla T, Jakobs KH, Meyer zu Heringdorf D. Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. Biochimica Et Biophysica Acta. 1791: 357-70. PMID 19830907 DOI: 10.1016/J.Bbalip.2009.01.019  0.491
2009 Hla T. Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells. Circulation Research. 105: 614-6. PMID 19797192 DOI: 10.1161/Circresaha.109.207068  0.39
2009 Skoura A, Hla T. Regulation of vascular physiology and pathology by the S1P2 receptor subtype. Cardiovascular Research. 82: 221-8. PMID 19287048 DOI: 10.1093/Cvr/Cvp088  0.8
2009 Li MH, Sanchez T, Milne GL, Morrow JD, Hla T, Ferrer F. S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. The Journal of Urology. 181: 1347-52. PMID 19157443 DOI: 10.1016/J.Juro.2008.10.140  0.736
2009 Li MH, Sanchez T, Yamase H, Hla T, Oo ML, Pappalardo A, Lynch KR, Lin CY, Ferrer F. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Letters. 276: 171-9. PMID 19131156 DOI: 10.1016/J.Canlet.2008.11.025  0.743
2009 Ghosh M, Ai Y, Narko K, Wang Z, Peters JM, Hla T. PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. Prostaglandins & Other Lipid Mediators. 88: 97-100. PMID 19101649 DOI: 10.1016/J.Prostaglandins.2008.11.004  0.578
2009 Skoura A, Hla T. Lysophospholipid receptors in vertebrate development, physiology, and pathology. Journal of Lipid Research. 50: S293-8. PMID 19065000 DOI: 10.1194/Jlr.R800047-Jlr200  0.736
2008 Li MH, Sanchez T, Pappalardo A, Lynch KR, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Molecular Cancer Research : McR. 6: 1649-56. PMID 18922980 DOI: 10.1158/1541-7786.Mcr-07-2048  0.753
2008 Estrada R, Zeng Q, Lu H, Sarojini H, Lee JF, Mathis SP, Sanchez T, Wang E, Kontos CD, Lin CY, Hla T, Haribabu B, Lee MJ. Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. The Journal of Biological Chemistry. 283: 30363-75. PMID 18765664 DOI: 10.1074/Jbc.M804392200  0.764
2008 Hla T, Venkataraman K, Michaud J. The vascular S1P gradient-cellular sources and biological significance. Biochimica Et Biophysica Acta. 1781: 477-82. PMID 18674637 DOI: 10.1016/J.Bbalip.2008.07.003  0.777
2008 Venkataraman K, Lee YM, Michaud J, Thangada S, Ai Y, Bonkovsky HL, Parikh NS, Habrukowich C, Hla T. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circulation Research. 102: 669-76. PMID 18258856 DOI: 10.1161/Circresaha.107.165845  0.812
2008 Sekiguchi M, Iwasaki T, Kitano M, Kuno H, Hashimoto N, Kawahito Y, Azuma M, Hla T, Sano H. Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. Journal of Immunology (Baltimore, Md. : 1950). 180: 1921-8. PMID 18209090 DOI: 10.4049/Jimmunol.180.3.1921  0.466
2008 Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange. The Journal of Biological Chemistry. 283: 3433-44. PMID 18083712 DOI: 10.1074/Jbc.M705409200  0.598
2008 Sanchez T, Pappalardo A, Li M, Hla T, Ferrer F. TARGETING SPHINGOSINE-1-PHOSPHATE RECEPTORS AS ANTI-TUMOR AND ANTI-ANGIOGENIC THERAPY IN RENAL CELL CARCINOMA Journal of Urology. 179: 40-40. DOI: 10.1016/S0022-5347(08)60122-6  0.671
2007 Lee YM, Venkataraman K, Hwang SI, Han DK, Hla T. A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). Prostaglandins & Other Lipid Mediators. 84: 154-62. PMID 17991617 DOI: 10.1016/J.Prostaglandins.2007.08.001  0.632
2007 Ghosh M, Wang H, Ai Y, Romeo E, Luyendyk JP, Peters JM, Mackman N, Dey SK, Hla T. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. The Journal of Experimental Medicine. 204: 2053-61. PMID 17724132 DOI: 10.1084/Jem.20070828  0.635
2007 Skoura A, Sanchez T, Claffey K, Mandala SM, Proia RL, Hla T. Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. The Journal of Clinical Investigation. 117: 2506-16. PMID 17710232 DOI: 10.1172/Jci31123  0.836
2007 Soldi R, Mandinova A, Venkataraman K, Hla T, Vadas M, Pitson S, Duarte M, Graziani I, Kolev V, Kacer D, Kirov A, Maciag T, Prudovsky I. Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Experimental Cell Research. 313: 3308-18. PMID 17643421 DOI: 10.1016/J.Yexcr.2007.05.031  0.662
2007 Sanchez T, Skoura A, Wu MT, Casserly B, Harrington EO, Hla T. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1312-8. PMID 17431187 DOI: 10.1161/Atvbaha.107.143735  0.832
2007 Kono M, Belyantseva IA, Skoura A, Frolenkov GI, Starost MF, Dreier JL, Lidington D, Bolz SS, Friedman TB, Hla T, Proia RL. Deafness and stria vascularis defects in S1P2 receptor-null mice. The Journal of Biological Chemistry. 282: 10690-6. PMID 17284444 DOI: 10.1074/Jbc.M700370200  0.782
2007 Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. The Journal of Biological Chemistry. 282: 9082-9. PMID 17237497 DOI: 10.1074/Jbc.M610318200  0.835
2007 Gonzalez-Cabrera PJ, Hla T, Rosen H. Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. The Journal of Biological Chemistry. 282: 7254-64. PMID 17218309 DOI: 10.1074/Jbc.M610581200  0.471
2006 Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL, Hla T. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Molecular and Cellular Biology. 26: 7211-23. PMID 16980623 DOI: 10.1128/Mcb.02341-05  0.814
2006 Lee JF, Zeng Q, Ozaki H, Wang L, Hand AR, Hla T, Wang E, Lee MJ. Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. The Journal of Biological Chemistry. 281: 29190-200. PMID 16891661 DOI: 10.1074/Jbc.M604310200  0.643
2006 Michaud J, Kohno M, Proia RL, Hla T. Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice. Febs Letters. 580: 4607-12. PMID 16876794 DOI: 10.1016/J.Febslet.2006.07.035  0.717
2006 Thompson B, Ancellin N, Fernandez SM, Hla T, Sha'afi RI. Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. Prostaglandins & Other Lipid Mediators. 80: 15-27. PMID 16846783 DOI: 10.1016/J.Prostaglandins.2006.03.002  0.77
2006 Subbaramaiah K, Howe LR, Port ER, Brogi E, Fishman J, Liu CH, Hla T, Hudis C, Dannenberg AJ. HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. Cancer Research. 66: 5504-11. PMID 16707480 DOI: 10.1158/0008-5472.Can-05-4076  0.593
2006 Venkataraman K, Thangada S, Michaud J, Oo ML, Ai Y, Lee YM, Wu M, Parikh NS, Khan F, Proia RL, Hla T. Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. The Biochemical Journal. 397: 461-71. PMID 16623665 DOI: 10.1042/Bj20060251  0.836
2006 Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis and Rheumatism. 54: 742-53. PMID 16508938 DOI: 10.1002/Art.21668  0.44
2006 Lee JF, Ozaki H, Zhan X, Wang E, Hla T, Lee MJ. Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. Histochemistry and Cell Biology. 126: 297-304. PMID 16416022 DOI: 10.1007/S00418-006-0143-Z  0.675
2006 LaMontagne K, Littlewood-Evans A, Schnell C, O'Reilly T, Wyder L, Sanchez T, Probst B, Butler J, Wood A, Liau G, Billy E, Theuer A, Hla T, Wood J. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Research. 66: 221-31. PMID 16397235 DOI: 10.1158/0008-5472.Can-05-2001  0.685
2006 Camp SM, Dudek SM, Chiang ET, Singleton PA, Bittman R, Sanchez T, Hla T, Garcia JG. 55 NOVEL ANALOGS OF FTY720 PROMOTE PULMONARY VASCULAR BARRIER FUNCTION. Journal of Investigative Medicine. 54: S352.4-S352. DOI: 10.2310/6650.2005.X0015.54  0.64
2006 Zani S, Momoi M, Paik J, Hla T, Frederick W. 127 POSTER Down-regulation of Sphingosine 1-Phosphate Receptor-1 in intestinal tumorigenesis European Journal of Cancer Supplements. 4: 42. DOI: 10.1016/S1359-6349(06)70133-1  0.399
2006 Li Z, Paik J, Wang Z, Hla T, Wu D. Corrigendum to “Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells” [Prostag. Oth. Lipid. M. 76 (2005) 95–104] Prostaglandins & Other Lipid Mediators. 79: 195. DOI: 10.1016/J.Prostaglandins.2005.10.003  0.572
2005 Howe LR, Chang SH, Tolle KC, Dillon R, Young LJ, Cardiff RD, Newman RA, Yang P, Thaler HT, Muller WJ, Hudis C, Brown AM, Hla T, Subbaramaiah K, Dannenberg AJ. HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Cancer Research. 65: 10113-9. PMID 16267038 DOI: 10.1158/0008-5472.Can-05-1524  0.55
2005 Hla T. Genomic insights into mediator lipidomics. Prostaglandins & Other Lipid Mediators. 77: 197-209. PMID 16099404 DOI: 10.1016/J.Prostaglandins.2005.06.008  0.378
2005 Chae SS, Hla T. Inhibition of gene expression in vivo using multiplex siRNA. Methods in Molecular Biology (Clifton, N.J.). 309: 197-203. PMID 15990401 DOI: 10.1385/1-59259-935-4:197  0.657
2005 Jo E, Sanna MG, Gonzalez-Cabrera PJ, Thangada S, Tigyi G, Osborne DA, Hla T, Parrill AL, Rosen H. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chemistry & Biology. 12: 703-15. PMID 15975516 DOI: 10.1016/J.Chembiol.2005.04.019  0.776
2005 Li Z, Paik JH, Paik JH, Wang Z, Hla T, Wu D. Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins & Other Lipid Mediators. 76: 95-104. PMID 15967165 DOI: 10.1016/J.Prostaglandins.2005.02.002  0.607
2005 Narko K, Zweifel B, Trifan O, Ristimäki A, Lane TF, Hla T. COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. Prostaglandins & Other Lipid Mediators. 76: 86-94. PMID 15967164 DOI: 10.1016/J.Prostaglandins.2005.01.002  0.765
2005 Chang SH, Liu CH, Wu MT, Hla T. Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor. Prostaglandins & Other Lipid Mediators. 76: 48-58. PMID 15967161 DOI: 10.1016/J.Prostaglandins.2004.12.001  0.756
2005 Chang SH, Ai Y, Breyer RM, Lane TF, Hla T. The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. Cancer Research. 65: 4496-9. PMID 15930264 DOI: 10.1158/0008-5472.Can-05-0129  0.619
2005 Lepley D, Paik JH, Hla T, Ferrer F. The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer Research. 65: 3788-95. PMID 15867375 DOI: 10.1158/0008-5472.Can-04-2311  0.757
2005 Li Z, Dong X, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D. Regulation of PTEN by Rho small GTPases. Nature Cell Biology. 7: 399-404. PMID 15793569 DOI: 10.1038/Ncb1236  0.39
2005 Heinonen M, Bono P, Narko K, Chang SH, Lundin J, Joensuu H, Furneaux H, Hla T, Haglund C, Ristimäki A. Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. Cancer Research. 65: 2157-61. PMID 15781626 DOI: 10.1158/0008-5472.Can-04-3765  0.634
2005 Sanchez T, Thangada S, Wu MT, Kontos CD, Wu D, Wu H, Hla T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proceedings of the National Academy of Sciences of the United States of America. 102: 4312-7. PMID 15764699 DOI: 10.1073/Pnas.0409784102  0.832
2004 Chae SS, Paik JH, Furneaux H, Hla T. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. The Journal of Clinical Investigation. 114: 1082-9. PMID 15489955 DOI: 10.1172/Jci22716  0.778
2004 Knostman KA, Cho JY, Ryu KY, Lin X, McCubrey JA, Hla T, Liu CH, Di Carlo E, Keri R, Zhang M, Hwang DY, Kisseberth WC, Capen CC, Jhiang SM. Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. The Journal of Clinical Endocrinology and Metabolism. 89: 5196-203. PMID 15472226 DOI: 10.1210/Jc.2004-0907  0.574
2004 Paik JH, Skoura A, Chae SS, Cowan AE, Han DK, Proia RL, Hla T. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes & Development. 18: 2392-403. PMID 15371328 DOI: 10.1101/Gad.1227804  0.838
2004 Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacological Reviews. 56: 387-437. PMID 15317910 DOI: 10.1124/Pr.56.3.3  0.3
2004 Hla T. Physiological and pathological actions of sphingosine 1-phosphate. Seminars in Cell & Developmental Biology. 15: 513-20. PMID 15271296 DOI: 10.1016/J.Semcdb.2004.05.002  0.51
2004 Sanchez T, Hla T. Structural and functional characteristics of S1P receptors. Journal of Cellular Biochemistry. 92: 913-22. PMID 15258915 DOI: 10.1002/Jcb.20127  0.677
2004 Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 4: 1019-25. PMID 15196057 DOI: 10.1111/J.1600-6143.2004.00476.X  0.485
2004 Chae SS, Proia RL, Hla T. Constitutive expression of the S1P1 receptor in adult tissues. Prostaglandins & Other Lipid Mediators. 73: 141-50. PMID 15165038 DOI: 10.1016/J.Prostaglandins.2004.01.006  0.767
2004 Chae SS, Paik JH, Allende ML, Proia RL, Hla T. Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Developmental Biology. 268: 441-7. PMID 15063179 DOI: 10.1016/J.Ydbio.2004.01.001  0.804
2004 Saba JD, Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circulation Research. 94: 724-34. PMID 15059942 DOI: 10.1161/01.Res.0000122383.60368.24  0.504
2004 Jang BC, Kim DH, Park JW, Kwon TK, Kim SP, Song DK, Park JG, Bae JH, Mun KC, Baek WK, Suh MH, Hla T, Suh SI. Induction of cyclooxygenase-2 in macrophages by catalase: role of NF-kappaB and PI3K signaling pathways. Biochemical and Biophysical Research Communications. 316: 398-406. PMID 15020231 DOI: 10.1016/J.Bbrc.2004.02.060  0.638
2004 Chang SH, Liu CH, Conway R, Han DK, Nithipatikom K, Trifan OC, Lane TF, Hla T. Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 101: 591-6. PMID 14688410 DOI: 10.1073/Pnas.2535911100  0.817
2003 Erkinheimo TL, Lassus H, Sivula A, Sengupta S, Furneaux H, Hla T, Haglund C, Butzow R, Ristimäki A. Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Research. 63: 7591-4. PMID 14633672  0.47
2003 Trifan OC, Hla T. Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. Journal of Cellular and Molecular Medicine. 7: 207-22. PMID 14594546 DOI: 10.1111/J.1582-4934.2003.Tb00222.X  0.756
2003 Ozaki H, Hla T, Lee MJ. Sphingosine-1-phosphate signaling in endothelial activation. Journal of Atherosclerosis and Thrombosis. 10: 125-31. PMID 14564080 DOI: 10.5551/Jat.10.125  0.665
2003 Sanchez T, Estrada-Hernandez T, Paik JH, Wu MT, Venkataraman K, Brinkmann V, Claffey K, Hla T. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. The Journal of Biological Chemistry. 278: 47281-90. PMID 12954648 DOI: 10.1074/Jbc.M306896200  0.799
2003 Sengupta S, Jang BC, Wu MT, Paik JH, Furneaux H, Hla T. The RNA-binding protein HuR regulates the expression of cyclooxygenase-2. The Journal of Biological Chemistry. 278: 25227-33. PMID 12704185 DOI: 10.1074/Jbc.M301813200  0.695
2003 Hla T. Signaling and biological actions of sphingosine 1-phosphate. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 47: 401-7. PMID 12676514 DOI: 10.1016/S1043-6618(03)00046-X  0.511
2003 Donohue PJ, Richards CM, Brown SA, Hanscom HN, Buschman J, Thangada S, Hla T, Williams MS, Winkles JA. TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 594-600. PMID 12615668 DOI: 10.1161/01.Atv.0000062883.93715.37  0.767
2003 Inaba T, Sano H, Kawahito Y, Hla T, Akita K, Toda M, Yamashina I, Inoue M, Nakada H. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 2736-41. PMID 12598658 DOI: 10.1073/Pnas.0435410100  0.372
2003 Kluk MJ, Colmont C, Wu MT, Hla T. Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells. Febs Letters. 533: 25-8. PMID 12505153 DOI: 10.1016/S0014-5793(02)03742-0  0.753
2003 Jang BC, Muñoz-Najar U, Paik JH, Claffey K, Yoshida M, Hla T. Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. The Journal of Biological Chemistry. 278: 2773-6. PMID 12468543 DOI: 10.1074/Jbc.C200620200  0.722
2002 Bishop-Bailey D, Hla T, Warner TD. Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy. Circulation Research. 91: 210-7. PMID 12169646 DOI: 10.1161/01.Res.0000029080.15742.85  0.671
2002 Bishop-Bailey D, Calatayud S, Warner TD, Hla T, Mitchell JA. Prostaglandins and the regulation of tumor growth. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society For Environmental Toxicology and Cancer. 21: 93-101. PMID 12086407 DOI: 10.1615/Jenvironpatholtoxicoloncol.V21.I2.20  0.704
2002 Kluk MJ, Hla T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochimica Et Biophysica Acta. 1582: 72-80. PMID 12069812 DOI: 10.1016/S1388-1981(02)00139-7  0.733
2002 Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W, Pyne S, Tigyi G. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 54: 265-9. PMID 12037142 DOI: 10.1124/Pr.54.2.265  0.483
2002 Ancellin N, Colmont C, Su J, Li Q, Mittereder N, Chae SS, Stefansson S, Liau G, Hla T. Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. The Journal of Biological Chemistry. 277: 6667-75. PMID 11741921 DOI: 10.1074/Jbc.M102841200  0.85
2001 Goetzl EJ, Tigyi GJ, Hla T. First international conference on lysophospholipids and related bioactive lipids in biology and disease sponsored by the Federation of American Societies of Experimental Biology. Thescientificworldjournal. 1: 269-70. PMID 12806083 DOI: 10.1100/Tsw.2001.65  0.487
2001 Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ. Lysophospholipids--receptor revelations. Science (New York, N.Y.). 294: 1875-8. PMID 11729304 DOI: 10.1126/Science.1065323  0.809
2001 Inoue K, Kawahito Y, Tsubouchi Y, Yamada R, Kohno M, Hosokawa Y, Katoh D, Bishop-Bailey D, Hla T, Sano H. Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer. Anticancer Research. 21: 2471-6. PMID 11724309  0.694
2001 Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, Wu M, Morales-Ruiz M, Sessa WC, Alessi DR, Hla T. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Molecular Cell. 8: 693-704. PMID 11583630 DOI: 10.1016/S1097-2765(01)00324-0  0.828
2001 Kluk MJ, Hla T. Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circulation Research. 89: 496-502. PMID 11557736 DOI: 10.1161/Hh1801.096338  0.733
2001 Tsubouchi Y, Kawahito Y, Kohno M, Inoue K, Hla T, Sano H. Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2. Biochemical and Biophysical Research Communications. 283: 750-5. PMID 11350047 DOI: 10.1006/Bbrc.2001.4847  0.537
2001 Hla T. Sphingosine 1-phosphate receptors. Prostaglandins & Other Lipid Mediators. 64: 135-42. PMID 11324703 DOI: 10.1016/S0090-6980(01)00109-5  0.489
2001 Liu CH, Chang SH, Narko K, Trifan OC, Wu MT, Smith E, Haudenschild C, Lane TF, Hla T. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. The Journal of Biological Chemistry. 276: 18563-9. PMID 11278747 DOI: 10.1074/Jbc.M010787200  0.795
2001 Morales-Ruiz M, Lee MJ, Zöllner S, Gratton JP, Scotland R, Shiojima I, Walsh K, Hla T, Sessa WC. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. The Journal of Biological Chemistry. 276: 19672-7. PMID 11278592 DOI: 10.1074/Jbc.M009993200  0.604
2001 Casibang M, Purdom S, Jakowlew S, Neckers L, Zia F, Ben-Av P, Hla T, You L, Jablons DM, Moody TW. Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells. Lung Cancer (Amsterdam, Netherlands). 31: 203-12. PMID 11165399 DOI: 10.1016/S0169-5002(00)00168-9  0.39
2001 Paik JH, Chae Ss, Lee MJ, Thangada S, Hla T. Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. The Journal of Biological Chemistry. 276: 11830-7. PMID 11150298 DOI: 10.1074/Jbc.M009422200  0.815
2000 Liu Y, Wada R, Yamashita T, Mi Y, Deng CX, Hobson JP, Rosenfeldt HM, Nava VE, Chae SS, Lee MJ, Liu CH, Hla T, Spiegel S, Proia RL. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. The Journal of Clinical Investigation. 106: 951-61. PMID 11032855 DOI: 10.1172/Jci10905  0.827
2000 Bishop-Bailey D, Hla T, Warner TD. Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line. British Journal of Pharmacology. 131: 651-4. PMID 11030710 DOI: 10.1038/Sj.Bjp.0703628  0.699
2000 Jang BC, Sanchez T, Schaefers HJ, Trifan OC, Liu CH, Creminon C, Huang CK, Hla T. Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase. The Journal of Biological Chemistry. 275: 39507-15. PMID 10993880 DOI: 10.1074/Jbc.M003224200  0.802
2000 Kawahito Y, Kondo M, Tsubouchi Y, Hashiramoto A, Bishop-Bailey D, Inoue K, Kohno M, Yamada R, Hla T, Sano H. 15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. The Journal of Clinical Investigation. 106: 189-97. PMID 10903334 DOI: 10.1172/Jci9652  0.737
2000 Ancellin N, Hla T. Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. Annals of the New York Academy of Sciences. 905: 260-2. PMID 10818459 DOI: 10.1111/J.1749-6632.2000.Tb06555.X  0.727
2000 Hla T, Lee MJ, Ancellin N, Thangada S, Liu CH, Kluk M, Chae SS, Wu MT. Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. Annals of the New York Academy of Sciences. 905: 16-24. PMID 10818438 DOI: 10.1111/J.1749-6632.2000.Tb06534.X  0.824
2000 Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. The Journal of Biological Chemistry. 275: 14281-6. PMID 10799507 DOI: 10.1074/Jbc.275.19.14281  0.735
2000 Tsubouchi Y, Sano H, Kawahito Y, Mukai S, Yamada R, Kohno M, Inoue K, Hla T, Kondo M. Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. Biochemical and Biophysical Research Communications. 270: 400-5. PMID 10753637 DOI: 10.1006/Bbrc.2000.2436  0.559
2000 Yamada R, Sano H, Hla T, Hashiramoto A, Kawahito Y, Mukai S, Kohno M, Tsubouchi Y, Inoue M, Komatsu A, Inoue K, Kondo M. Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis. Biochemical and Biophysical Research Communications. 269: 415-21. PMID 10708568 DOI: 10.1006/Bbrc.2000.2303  0.538
2000 Clark RB, Bishop-Bailey D, Estrada-Hernandez T, Hla T, Puddington L, Padula SJ. The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 164: 1364-71. PMID 10640751 DOI: 10.4049/Jimmunol.164.3.1364  0.685
1999 Yamada R, Sano H, Hla T, Hashiramoto A, Fukui W, Miyazaki S, Kohno M, Tsubouchi Y, Kusaka Y, Kondo M. Auranofin inhibits interleukin-1beta-induced transcript of cyclooxygenase-2 on cultured human synoviocytes. European Journal of Pharmacology. 385: 71-9. PMID 10594346 DOI: 10.1016/S0014-2999(99)00707-4  0.531
1999 Trifan OC, Smith RM, Thompson BD, Hla T. Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism. The Journal of Biological Chemistry. 274: 34141-7. PMID 10567385 DOI: 10.1074/Jbc.274.48.34141  0.753
1999 Lee MJ, Thangada S, Claffey KP, Ancellin N, Liu CH, Kluk M, Volpi M, Sha'afi RI, Hla T. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell. 99: 301-12. PMID 10555146 DOI: 10.1016/S0092-8674(00)81661-X  0.83
1999 Windh RT, Lee MJ, Hla T, An S, Barr AJ, Manning DR. Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. The Journal of Biological Chemistry. 274: 27351-8. PMID 10488065 DOI: 10.1074/Jbc.274.39.27351  0.503
1999 Hla T, Lee MJ, Ancellin N, Liu CH, Thangada S, Thompson BD, Kluk M. Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? Biochemical Pharmacology. 58: 201-7. PMID 10423159 DOI: 10.1016/S0006-2952(99)00086-6  0.809
1999 Hla T, Bishop-Bailey D, Liu CH, Schaefers HJ, Trifan OC. Cyclooxygenase-1 and -2 isoenzymes. The International Journal of Biochemistry & Cell Biology. 31: 551-7. PMID 10399316 DOI: 10.1016/S1357-2725(98)00152-6  0.811
1999 Ancellin N, Hla T. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. The Journal of Biological Chemistry. 274: 18997-9002. PMID 10383399 DOI: 10.1074/Jbc.274.27.18997  0.748
1999 Bishop-Bailey D, Hla T. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. The Journal of Biological Chemistry. 274: 17042-8. PMID 10358055 DOI: 10.1074/Jbc.274.24.17042  0.701
1999 Liu CH, Thangada S, Lee MJ, Van Brocklyn JR, Spiegel S, Hla T. Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Molecular Biology of the Cell. 10: 1179-90. PMID 10198065 DOI: 10.1091/Mbc.10.4.1179  0.821
1999 Bishop-Bailey D, Hla T, Mitchell JA. Cyclo-oxygenase-2 in vascular smooth muscle. International Journal of Molecular Medicine. 3: 41-8. PMID 9864384 DOI: 10.3892/Ijmm.3.1.41  0.672
1999 Hla T, Lee M, Anellin N, Liu CH, Thangada S, Kluk M. EDG-1 family of sphingosine-1-phosphate (SPP) receptors Prostaglandins & Other Lipid Mediators. 59: 93. DOI: 10.1016/S0090-6980(99)90328-3  0.787
1998 Lee MJ, Thangada S, Liu CH, Thompson BD, Hla T. Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. The Journal of Biological Chemistry. 273: 22105-12. PMID 9705355 DOI: 10.1074/Jbc.273.34.22105  0.827
1998 Van Brocklyn JR, Lee MJ, Menzeleev R, Olivera A, Edsall L, Cuvillier O, Thomas DM, Coopman PJ, Thangada S, Liu CH, Hla T, Spiegel S. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. The Journal of Cell Biology. 142: 229-40. PMID 9660876 DOI: 10.1083/Jcb.142.1.229  0.819
1998 Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzeleev R, Spiegel S, Hla T. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science (New York, N.Y.). 279: 1552-5. PMID 9488656 DOI: 10.1126/Science.279.5356.1552  0.823
1998 Gou Q, Liu CH, Ben-Av P, Hla T. Dissociation of basal turnover and cytokine-induced transcript stabilization of the human cyclooxygenase-2 mRNA by mutagenesis of the 3'-untranslated region. Biochemical and Biophysical Research Communications. 242: 508-12. PMID 9464246 DOI: 10.1006/Bbrc.1997.7994  0.579
1998 Trifan OG, Bishop-Bailey D, Hla T. Inducible cyclooxygenase-2 overexpression using the ecdysone-inducible gene expression system Faseb Journal. 12: A1384.  0.782
1998 Van Brooklyn JR, Lee MJ, Menzeleev R, Qlivera A, Edsall L, Cuvillier O, Thomas PM, Coopman PJP, Thangada S, Liu CH, Hla T, Spiegel S. Dual actions of sphingosine-1-phosphate: Etracellular through the gi-coupled receptor Eg-1 and intracellular to regulate proliferation and survival Faseb Journal. 12: A1460.  0.774
1997 Hla T, Zimrin AB, Evans M, Ballas K, Maciag T. The immediate-early gene product MAD-3/EDG-3/IkappaB alpha is an endogenous modulator of fibroblast growth factor-1 (FGF-1) dependent human endothelial cell growth. Febs Letters. 414: 419-24. PMID 9315732 DOI: 10.1016/S0014-5793(97)01053-3  0.605
1997 Narko K, Ristimäki A, MacPhee M, Smith E, Haudenschild CC, Hla T. Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 overexpression. The Journal of Biological Chemistry. 272: 21455-60. PMID 9261162 DOI: 10.1074/Jbc.272.34.21455  0.599
1997 Liu CH, Hla T. The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 43: 15-24. PMID 9226368 DOI: 10.1006/Geno.1997.4759  0.638
1996 Hla T. Molecular characterization of the 5.2 KB isoform of the human cyclooxygenase-1 transcript. Prostaglandins. 51: 81-5. PMID 8900446 DOI: 10.1016/0090-6980(95)00158-1  0.341
1996 Ristimäki A, Narko K, Hla T. Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation. The Biochemical Journal. 318: 325-31. PMID 8761489 DOI: 10.1042/Bj3180325  0.554
1996 Lee MJ, Evans M, Hla T. The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. The Journal of Biological Chemistry. 271: 11272-9. PMID 8626678 DOI: 10.1074/Jbc.271.19.11272  0.572
1995 Hla T, Jackson AQ, Appleby SB, Maciag T. Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells. Biochimica Et Biophysica Acta. 1260: 227-9. PMID 7841202 DOI: 10.1016/0167-4781(94)00219-S  0.606
1995 Ben-Av P, Crofford LJ, Wilder RL, Hla T. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. Febs Letters. 372: 83-7. PMID 7556649 DOI: 10.1016/0014-5793(95)00956-A  0.461
1994 Ristimäki A, Garfinkel S, Wessendorf J, Maciag T, Hla T. Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation. The Journal of Biological Chemistry. 269: 11769-75. PMID 8163473  0.654
1994 Crofford LJ, Wilder RL, Ristimäki AP, Sano H, Remmers EF, Epps HR, Hla T. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. The Journal of Clinical Investigation. 93: 1095-101. PMID 8132748 DOI: 10.1172/Jci117060  0.526
1994 Appleby SB, Ristimäki A, Neilson K, Narko K, Hla T. Structure of the human cyclo-oxygenase-2 gene. The Biochemical Journal. 302: 723-7. PMID 7945196 DOI: 10.1042/Bj3020723  0.537
1993 Sano H, Engleka K, Mathern P, Hla T, Crofford LJ, Remmers EF, Jelsema CL, Goldmuntz E, Maciag T, Wilder RL. Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis. The Journal of Clinical Investigation. 91: 553-65. PMID 7679410 DOI: 10.1172/Jci116235  0.593
1993 Hla T, Ristimäki A, Appleby S, Barriocanal JG. Cyclooxygenase gene expression in inflammation and angiogenesis. Annals of the New York Academy of Sciences. 696: 197-204. PMID 7509130 DOI: 10.1111/J.1749-6632.1993.Tb17152.X  0.541
1992 Sano H, Hla T, Maier JA, Crofford LJ, Case JP, Maciag T, Wilder RL. In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. The Journal of Clinical Investigation. 89: 97-108. PMID 1729286 DOI: 10.1172/Jci115591  0.584
1992 Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proceedings of the National Academy of Sciences of the United States of America. 89: 7384-8. PMID 1380156 DOI: 10.1073/Pnas.89.16.7384  0.413
1991 Hla T, Maciag T. Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells. The Journal of Biological Chemistry. 266: 24059-63. PMID 1721064  0.614
1991 Siegall CB, Epstein S, Speir E, Hla T, Forough R, Maciag T, Fitzgerald DJ, Pastan I. Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2843-9. PMID 1717336 DOI: 10.1096/Fasebj.5.13.1717336  0.6
1991 Remmers EF, Sano H, Lafyatis R, Case JP, Kumkumian GK, Hla T, Maciag T, Wilder RL. Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1. The Journal of Rheumatology. 18: 7-13. PMID 1708827  0.534
1990 Hla T, Maciag T. Isolation of immediate-early differentiation mRNAs by enzymatic amplification of subtracted cDNA from human endothelial cells. Biochemical and Biophysical Research Communications. 167: 637-43. PMID 2322246 DOI: 10.1016/0006-291X(90)92072-8  0.623
1990 Hla T, Maciag T. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. The Journal of Biological Chemistry. 265: 9308-13. PMID 2160972  0.646
1990 Smith WL, DeWitt DL, Kraemer SA, Andrews MJ, Hla T, Maciag T, Shimokawa T. Structure-function relationships in sheep, mouse, and human prostaglandin endoperoxide G/H synthases. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 20: 14-21. PMID 2144687  0.513
1990 Imamura T, Engleka K, Zhan X, Tokita Y, Forough R, Roeder D, Jackson A, Maier JA, Hla T, Maciag T. Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science (New York, N.Y.). 249: 1567-70. PMID 1699274 DOI: 10.1126/Science.1699274  0.6
1990 Maier JA, Hla T, Maciag T. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. The Journal of Biological Chemistry. 265: 10805-8. PMID 1694171  0.563
1989 Goldgaber D, Harris HW, Hla T, Maciag T, Donnelly RJ, Jacobsen JS, Vitek MP, Gajdusek DC. Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 86: 7606-10. PMID 2508093 DOI: 10.1073/Pnas.86.19.7606  0.625
1989 Hla TT, Bailey JM. Differential recovery of prostacyclin synthesis in cultured vascular endothelial vs. smooth muscle cells after inactivation of cyclooxygenase with aspirin. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 36: 175-84. PMID 2506580 DOI: 10.1016/0952-3278(89)90059-8  0.533
1988 Siegall CB, Hla TT, Kumar A. Reconstituted U1 small nuclear ribonucleoprotein complex restores 5' splice site cleavage activity. Biochemical and Biophysical Research Communications. 154: 1010-7. PMID 2970258 DOI: 10.1016/0006-291X(88)90240-9  0.437
1986 Hla T, Farrell M, Kumar A, Bailey JM. Isolation of the cDNA for human prostaglandin H synthase. Prostaglandins. 32: 829-45. PMID 3104990 DOI: 10.1016/0090-6980(86)90093-6  0.657
1985 Bailey JM, Muza B, Hla T, Salata K. Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor. Journal of Lipid Research. 26: 54-61. PMID 3919134  0.517
1985 Gorodetsky JS, Hla TT, Bailey JM. Recovery of prostacyclin synthesis in human vascular endothelial cells following intermittent or continuous exposure to indomethacin. Pharmacological Research Communications. 17: 447-56. PMID 3898146  0.52
1985 Bailey JM, Muza B, Hla T, Pash J. Role of epidermal growth factor in cyclooxygenase synthesis. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 15: 141-2. PMID 2936078  0.441
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