| Year |
Citation |
Score |
| 2023 |
Datta D, Theile CS, Wassarman K, Qin J, Racie T, Schmidt K, Jiang Y, Sigel R, Janas MM, Egli M, Manoharan M. Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex. Chemical Communications (Cambridge, England). PMID 37144553 DOI: 10.1039/d3cc01143g |
0.656 |
|
| 2023 |
Anthiya S, Öztürk SC, Yanik H, Tavukcuoglu E, Sahin A, Datta D, Charisse K, Álvarez DM, Loza M, Calvo A, Sulheim E, Loevenich S, Klinkenberg G, Schmid R, Manoharan M, et al. Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 36921725 DOI: 10.1016/j.jconrel.2023.03.016 |
0.554 |
|
| 2023 |
Egli M, Manoharan M. Chemistry, structure and function of approved oligonucleotide therapeutics. Nucleic Acids Research. PMID 36881759 DOI: 10.1093/nar/gkad067 |
0.671 |
|
| 2023 |
Kandasamy P, Mori S, Matsuda S, Erande N, Datta D, Willoughby JLS, Taneja N, O'Shea J, Bisbe A, Manoharan RM, Yucius K, Nguyen T, Indrakanti R, Gupta S, Gilbert JA, ... ... Manoharan M, et al. Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of Medicinal Chemistry. PMID 36757090 DOI: 10.1021/acs.jmedchem.2c01337 |
0.624 |
|
| 2023 |
Ghosh A, Akabane-Nakata M, Kundu J, Harp JM, Madaoui M, Egli M, Manoharan M, Sinha S. Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic Letters. PMID 36734846 DOI: 10.1021/acs.orglett.2c04067 |
0.599 |
|
| 2023 |
Egli M, Schlegel MK, Manoharan M. Acyclic (S)-Glycol Nucleic Acid (S-GNA) Modification of siRNAs Improves the Safety of RNAi Therapeutics While Maintaining Potency. Rna (New York, N.Y.). PMID 36725319 DOI: 10.1261/rna.079526.122 |
0.642 |
|
| 2022 |
Clua A, Grijalvo S, Erande N, Gupta S, Yucius K, Gargallo R, Mazzini S, Manoharan M, Eritja R. Correction: Clua et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. 2022, , 3944. Molecules (Basel, Switzerland). 28. PMID 36615657 DOI: 10.3390/molecules28010098 |
0.496 |
|
| 2022 |
Engelbeen S, Pasteuning-Vuhman S, Boertje-van der Meulen J, Parmar R, Charisse K, Sepp-Lorenzino L, Manoharan M, Aartsma-Rus A, van Putten M. Efficient Downregulation of in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular Dystrophy. Nucleic Acid Therapeutics. PMID 36269327 DOI: 10.1089/nat.2022.0021 |
0.551 |
|
| 2022 |
Madaoui M, Datta D, Wassarman K, Zlatev I, Egli M, Ross BS, Manoharan M. A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups. Organic Letters. PMID 35973215 DOI: 10.1021/acs.orglett.2c01848 |
0.529 |
|
| 2022 |
Guenther DC, Mori S, Matsuda S, Gilbert JA, Willoughby JLS, Hyde S, Bisbe A, Jiang Y, Agarwal S, Madaoui M, Janas MM, Charisse K, Maier MA, Egli M, Manoharan M. Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β--methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects. Journal of the American Chemical Society. PMID 35921401 DOI: 10.1021/jacs.2c01679 |
0.598 |
|
| 2022 |
Clua A, Grijalvo S, Erande N, Gupta S, Yucius K, Gargallo R, Mazzini S, Manoharan M, Eritja R. Properties of Parallel Tetramolecular G-Quadruplex Carrying -Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules (Basel, Switzerland). 27. PMID 35745067 DOI: 10.3390/molecules27123944 |
0.554 |
|
| 2022 |
Schlegel MK, Janas MM, Jiang Y, Barry JD, Davis W, Agarwal S, Berman D, Brown CR, Castoreno A, LeBlanc S, Liebow A, Mayo T, Milstein S, Nguyen T, Shulga-Morskaya S, ... ... Manoharan M, et al. From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic Acids Research. PMID 35736224 DOI: 10.1093/nar/gkac539 |
0.645 |
|
| 2022 |
Datta D, Mori S, Madaoui M, Wassarman K, Zlatev I, Manoharan M. Aminooxy Click Chemistry as a Tool for Bis-homo and Bis-hetero Ligand Conjugation to Nucleic Acids. Organic Letters. 24: 4496-4501. PMID 35715221 DOI: 10.1021/acs.orglett.2c00988 |
0.52 |
|
| 2022 |
Brown KM, Nair JK, Janas MM, Anglero-Rodriguez YI, Dang LTH, Peng H, Theile CS, Castellanos-Rizaldos E, Brown C, Foster D, Kurz J, Allen J, Maganti R, Li J, Matsuda S, ... ... Manoharan M, et al. Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates. Nature Biotechnology. PMID 35654979 DOI: 10.1038/s41587-022-01334-x |
0.63 |
|
| 2022 |
Akabane-Nakata M, Chickering T, Harp JM, Schlegel MK, Matsuda S, Egli M, Manoharan M. RNAs Containing Carbocyclic Ribonucleotides. Organic Letters. 24: 525-530. PMID 34958225 DOI: 10.1021/acs.orglett.1c03936 |
0.646 |
|
| 2022 |
Corey DR, Damha MJ, Manoharan M. Challenges and Opportunities for Nucleic Acid Therapeutics. Nucleic Acid Therapeutics. 32: 8-13. PMID 34931905 DOI: 10.1089/nat.2021.0085 |
0.604 |
|
| 2021 |
Khare P, Dave KM, Kamte YS, Manoharan MA, O'Donnell LA, Manickam DS. Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells. The Aaps Journal. 24: 8. PMID 34873640 DOI: 10.1208/s12248-021-00653-2 |
0.56 |
|
| 2021 |
Schlegel MK, Matsuda S, Brown CR, Harp JM, Barry JD, Berman D, Castoreno A, Schofield S, Szeto J, Manoharan M, Charissé K, Egli M, Maier MA. Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs. Nucleic Acids Research. PMID 34648028 DOI: 10.1093/nar/gkab916 |
0.65 |
|
| 2021 |
Jahns H, Degaonkar R, Podbevsek P, Gupta S, Bisbe A, Aluri K, Szeto J, Kumar P, LeBlanc S, Racie T, Brown CR, Castoreno A, Guenther DC, Jadhav V, Maier MA, ... ... Manoharan M, et al. Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing. Nucleic Acids Research. PMID 34508350 DOI: 10.1093/nar/gkab724 |
0.682 |
|
| 2021 |
Jahns H, Taneja N, Willoughby JLS, Akabane-Nakata M, Brown CR, Nguyen T, Bisbe A, Matsuda S, Hettinger M, Manoharan RM, Rajeev KG, Maier MA, Zlatev I, Charisse K, Egli M, ... Manoharan M, et al. Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo. Nucleic Acids Research. PMID 34268578 DOI: 10.1093/nar/gkab544 |
0.649 |
|
| 2021 |
Chong S, Agarwal S, Agarwal S, Aluri KC, Arciprete M, Brown C, Charisse K, Cichocki J, Fitzgerald K, Goel V, Gu Y, Guenther D, Habtemariam B, Jadhav V, Janas M, ... ... Manoharan M, et al. The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 34154993 DOI: 10.1124/dmd.121.000428 |
0.569 |
|
| 2021 |
Klein D, Goldberg S, Theile CS, Dambra R, Haskell K, Kuhar E, Lin T, Parmar R, Manoharan M, Richter M, Wu M, Zarazowski JM, Jadhav V, Maier MA, Sepp-Lorenzino L, et al. Centyrin Ligands for Extrahepatic Delivery of siRNA. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33601052 DOI: 10.1016/j.ymthe.2021.02.015 |
0.601 |
|
| 2021 |
Akabane-Nakata M, Erande ND, Kumar P, Degaonkar R, Gilbert JA, Qin J, Mendez M, Woods LB, Jiang Y, Janas MM, O'Flaherty DK, Zlatev I, Schlegel MK, Matsuda S, Egli M, ... Manoharan M, et al. siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs. Nucleic Acids Research. PMID 33577685 DOI: 10.1093/nar/gkab050 |
0.56 |
|
| 2020 |
Pallan PS, Lybrand TP, Schlegel MK, Harp JM, Jahns H, Manoharan M, Egli M. Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost. Biochemistry. PMID 33275419 DOI: 10.1021/acs.biochem.0c00685 |
0.626 |
|
| 2020 |
Mikami A, Erande N, Matsuda S, Kel'in A, Woods LB, Chickering T, Pallan PS, Schlegel MK, Zlatev I, Egli M, Manoharan M. Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine. Nucleic Acids Research. PMID 32990754 DOI: 10.1093/nar/gkaa750 |
0.574 |
|
| 2020 |
Brown CR, Gupta S, Qin J, Racie T, He G, Lentini S, Malone R, Yu M, Matsuda S, Shulga-Morskaya S, Nair AV, Theile CS, Schmidt K, Shahraz A, Goel V, ... ... Manoharan M, et al. Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates. Nucleic Acids Research. PMID 32808038 DOI: 10.1093/Nar/Gkaa670 |
0.579 |
|
| 2020 |
Ganesh KN, Bhingardeve P, Madhanagopal BR, Jain P, Naick H, Manoharan M. Receptor-Specific Delivery of Peptide Nucleic Acids Conjugated to Three Sequentially Linked N-Acetyl Galactosamine Moieties into Hepatocytes. The Journal of Organic Chemistry. PMID 32529829 DOI: 10.1021/Acs.Joc.0C00601 |
0.635 |
|
| 2020 |
Kumar P, Degaonkar R, Guenther DC, Abramov M, Schepers G, Capobianco M, Jiang Y, Harp J, Kaittanis C, Janas MM, Castoreno A, Zlatev I, Schlegel MK, Herdewijn P, Egli M, ... Manoharan M, et al. Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease. Nucleic Acids Research. PMID 32170309 DOI: 10.1093/Nar/Gkaa125 |
0.657 |
|
| 2020 |
Akabane-Nakata M, Kumar P, Erande ND, Matsuda S, Manoharan M. Synthesis of 2'-Fluorinated Northern Methanocarbacyclic (2'-F-NMC) Nucleosides and Their Incorporation Into Oligonucleotides. Current Protocols in Nucleic Acid Chemistry. 80: e103. PMID 31985895 DOI: 10.1002/cpnc.103 |
0.518 |
|
| 2019 |
Akinc A, Maier MA, Manoharan M, Fitzgerald K, Jayaraman M, Barros S, Ansell S, Du X, Hope MJ, Madden TD, Mui BL, Semple SC, Tam YK, Ciufolini M, Witzigmann D, et al. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs. Nature Nanotechnology. 14: 1084-1087. PMID 31802031 DOI: 10.1038/S41565-019-0591-Y |
0.573 |
|
| 2019 |
Kumar P, Parmar RG, Brown CR, Willoughby JLS, Foster DJ, Babu IR, Schofield S, Jadhav V, Charisse K, Nair JK, Rajeev KG, Maier MA, Egli M, Manoharan M. 5'-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger. Chemical Communications (Cambridge, England). PMID 30977478 DOI: 10.1039/C9Cc00977A |
0.629 |
|
| 2019 |
Egli M, Manoharan M. Re-Engineering RNA Molecules into Therapeutic Agents. Accounts of Chemical Research. PMID 30912917 DOI: 10.1021/Acs.Accounts.8B00650 |
0.677 |
|
| 2019 |
Akabane-Nakata M, Kumar P, Das RS, Erande ND, Matsuda S, Egli M, Manoharan M. Synthesis and Biophysical Characterization of RNAs Containing 2'-Fluorinated Northern Methanocarbacyclic Nucleotides. Organic Letters. PMID 30892051 DOI: 10.1021/Acs.Orglett.8B04153 |
0.613 |
|
| 2019 |
Janas MM, Zlatev I, Liu J, Jiang Y, Barros SA, Sutherland JE, Davis WP, Liu J, Brown CR, Liu X, Schlegel MK, Blair L, Zhang X, Das B, Tran C, ... ... Manoharan M, et al. Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates. Nucleic Acids Research. PMID 30820542 DOI: 10.1093/Nar/Gkz140 |
0.589 |
|
| 2018 |
Harp JM, Guenther DC, Bisbe A, Perkins L, Matsuda S, Bommineni GR, Zlatev I, Foster DJ, Taneja N, Charisse K, Maier MA, Rajeev KG, Manoharan M, Egli M. Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. Nucleic Acids Research. PMID 30107495 DOI: 10.1093/nar/gky703 |
0.557 |
|
| 2018 |
Zlatev I, Castoreno A, Brown CR, Qin J, Waldron S, Schlegel MK, Degaonkar R, Shulga-Morskaya S, Xu H, Gupta S, Matsuda S, Akinc A, Rajeev KG, Manoharan M, Maier MA, et al. Reversal of siRNA-mediated gene silencing in vivo. Nature Biotechnology. PMID 29786096 DOI: 10.1038/Nbt.4136 |
0.678 |
|
| 2018 |
Janas MM, Schlegel MK, Harbison CE, Yilmaz VO, Jiang Y, Parmar R, Zlatev I, Castoreno A, Xu H, Shulga-Morskaya S, Rajeev KG, Manoharan M, Keirstead ND, Maier MA, Jadhav V. Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity. Nature Communications. 9: 723. PMID 29459660 DOI: 10.1038/S41467-018-02989-4 |
0.622 |
|
| 2018 |
Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S. Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29456020 DOI: 10.1016/J.Ymthe.2017.12.021 |
0.64 |
|
| 2018 |
Spasic A, Kennedy SD, Needham L, Manoharan M, Kierzek R, Turner DH, Mathews D. Molecular Dynamics Correctly Models the Unusual Major Conformation of the GAGU RNA Internal Loop and with NMR Reveals an Unusual Minor Conformation. Rna (New York, N.Y.). PMID 29434035 DOI: 10.1261/Rna.064527.117 |
0.546 |
|
| 2018 |
Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG. Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates. Journal of Medicinal Chemistry. PMID 29376650 DOI: 10.1021/Acs.Jmedchem.7B01147 |
0.616 |
|
| 2017 |
Willoughby JLS, Chan A, Sehgal A, Butler JS, Nair JK, Racie T, Shulga-Morskaya S, Nguyen T, Qian K, Yucius K, Charisse K, van Berkel TJC, Manoharan M, Rajeev KG, Maier MA, et al. Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28988716 DOI: 10.1016/J.Ymthe.2017.08.019 |
0.583 |
|
| 2017 |
Nair JK, Attarwala H, Sehgal A, Wang Q, Aluri K, Zhang X, Gao M, Liu J, Indrakanti R, Schofield S, Kretschmer P, Brown CR, Gupta S, Willoughby JLS, Boshar JA, ... ... Manoharan M, et al. Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates. Nucleic Acids Research. PMID 28981809 DOI: 10.1093/Nar/Gkx818 |
0.628 |
|
| 2017 |
Malek-Adamian E, Guenther D, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury JJ, Perkins L, Moitessier N, Manoharan R, Taneja N, Bisbe A, Charisse K, ... ... Manoharan M, et al. 4'-C-Methoxy-2'-Deoxy-2'-Fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing. Journal of the American Chemical Society. PMID 28937776 DOI: 10.1021/Jacs.7B07582 |
0.558 |
|
| 2017 |
Hao W, Wojdyla JA, Zhao R, Han R, Das R, Zlatev I, Manoharan M, Wang M, Cui S. Crystal structure of Middle East respiratory syndrome coronavirus helicase. Plos Pathogens. 13: e1006474. PMID 28651017 DOI: 10.1371/Journal.Ppat.1006474 |
0.488 |
|
| 2017 |
Schlegel MK, Foster DJ, Kel'in AV, Zlatev I, Bisbe A, Jayaraman M, Lackey JG, Rajeev KG, Charisse K, Harp J, Pallan PS, Maier MA, Egli M, Manoharan M. Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. Journal of the American Chemical Society. PMID 28570818 DOI: 10.1021/Jacs.7B02694 |
0.603 |
|
| 2016 |
Lee JB, Zhang K, Tam YY, Quick J, Tam YK, Lin PJ, Chen S, Liu Y, Nair JK, Zlatev I, Rajeev KG, Manoharan M, Rennie PS, Cullis PR. A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo. Molecular Therapy. Nucleic Acids. 5: e348. PMID 28131285 DOI: 10.1038/Mtna.2016.43 |
0.566 |
|
| 2016 |
Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L. siRNA carrying an (E)-vinylphosphonate moiety at the 5' end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2. Nucleic Acids Research. PMID 27986853 DOI: 10.1093/nar/gkw1298 |
0.564 |
|
| 2016 |
Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L. siRNA carrying an (E)-vinylphosphonate moiety at the 5' end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2. Nucleic Acids Research. PMID 27903888 DOI: 10.1093/Nar/Gkw1171 |
0.614 |
|
| 2016 |
Mobin MB, Gerstberger S, Teupser D, Campana B, Charisse K, Heim MH, Manoharan M, Tuschl T, Stoffel M. The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation. Nature Communications. 7: 12848. PMID 27665711 DOI: 10.1038/Ncomms12848 |
0.575 |
|
| 2016 |
Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, ... Manoharan M, et al. 5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates. Chembiochem : a European Journal of Chemical Biology. PMID 27121751 DOI: 10.1002/Cbic.201600130 |
0.614 |
|
| 2016 |
Butler JS, Chan A, Costelha S, Fishman S, Willoughby JL, Borland TD, Milstein S, Foster DJ, Gonçalves P, Chen Q, Qin J, Bettencourt BR, Sah DW, Alvarez R, Rajeev KG, ... Manoharan M, et al. Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-10. PMID 27033334 DOI: 10.3109/13506129.2016.1160882 |
0.579 |
|
| 2016 |
Kel In AV, Zlatev I, Harp J, Jayaraman M, Bisbe A, O Shea J, Taneja N, Manoharan RM, Khan S, Charisse K, Maier MA, Egli M, Rajeev KG, Manoharan M. Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. The Journal of Organic Chemistry. PMID 26940174 DOI: 10.1021/Acs.Joc.5B02375 |
0.534 |
|
| 2015 |
Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M. 5'-C-Malonyl RNA: small interfering RNAs modified with 5'-monophosphate bioisostere demonstrate gene silencing activity. Acs Chemical Biology. PMID 26675211 DOI: 10.1021/Acschembio.5B00654 |
0.649 |
|
| 2015 |
Chan A, Liebow A, Yasuda M, Gan L, Racie T, Maier M, Kuchimanchi S, Foster D, Milstein S, Charisse K, Sehgal A, Manoharan M, Meyers R, Fitzgerald K, Simon A, et al. Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification. Molecular Therapy. Nucleic Acids. 4: e263. PMID 26528940 DOI: 10.1038/Mtna.2015.36 |
0.581 |
|
| 2015 |
Gilleron J, Paramasivam P, Zeigerer A, Querbes W, Marsico G, Andree C, Seifert S, Amaya P, Stöter M, Koteliansky V, Waldmann H, Fitzgerald K, Kalaidzidis Y, Akinc A, Maier MA, ... Manoharan M, et al. Identification of siRNA delivery enhancers by a chemical library screen. Nucleic Acids Research. PMID 26220182 DOI: 10.1093/Nar/Gkv762 |
0.597 |
|
| 2015 |
Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nature Biotechnology. PMID 26192320 DOI: 10.1038/Nbt.3298 |
0.595 |
|
| 2015 |
Sehgal A, Barros S, Ivanciu L, Cooley B, Qin J, Racie T, Hettinger J, Carioto M, Jiang Y, Brodsky J, Prabhala H, Zhang X, Attarwala H, Hutabarat R, Foster D, ... ... Manoharan M, et al. An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. Nature Medicine. 21: 492-7. PMID 25849132 DOI: 10.1038/Nm.3847 |
0.554 |
|
| 2015 |
Rajeev KG, Nair JK, Jayaraman M, Charisse K, Taneja N, O'Shea J, Willoughby JL, Yucius K, Nguyen T, Shulga-Morskaya S, Milstein S, Liebow A, Querbes W, Borodovsky A, Fitzgerald K, ... ... Manoharan M, et al. Hepatocyte-specific delivery of siRNAs conjugated to novel non-nucleosidic trivalent N-acetylgalactosamine elicits robust gene silencing in vivo. Chembiochem : a European Journal of Chemical Biology. 16: 903-8. PMID 25786782 DOI: 10.1002/Cbic.201500023 |
0.609 |
|
| 2015 |
Matsuda S, Keiser K, Nair JK, Charisse K, Manoharan RM, Kretschmer P, Peng CG, V Kel'in A, Kandasamy P, Willoughby JL, Liebow A, Querbes W, Yucius K, Nguyen T, Milstein S, ... ... Manoharan M, et al. siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytes. Acs Chemical Biology. 10: 1181-7. PMID 25730476 DOI: 10.1021/Cb501028C |
0.637 |
|
| 2014 |
Nair JK, Willoughby JL, Chan A, Charisse K, Alam MR, Wang Q, Hoekstra M, Kandasamy P, Kel'in AV, Milstein S, Taneja N, O'Shea J, Shaikh S, Zhang L, van der Sluis RJ, ... ... Manoharan M, et al. Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing. Journal of the American Chemical Society. 136: 16958-61. PMID 25434769 DOI: 10.1021/Ja505986A |
0.612 |
|
| 2014 |
Hu J, Liu J, Narayanannair KJ, Lackey JG, Kuchimanchi S, Rajeev KG, Manoharan M, Swayze EE, Lima WF, Prakash TP, Xiang Q, Martinez C, Corey DR. Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs. Biochemistry. 53: 4510-8. PMID 24981774 DOI: 10.1021/Bi500610R |
0.622 |
|
| 2013 |
Mui BL, Tam YK, Jayaraman M, Ansell SM, Du X, Tam YY, Lin PJ, Chen S, Narayanannair JK, Rajeev KG, Manoharan M, Akinc A, Maier MA, Cullis P, Madden TD, et al. Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles. Molecular Therapy. Nucleic Acids. 2: e139. PMID 24345865 DOI: 10.1038/Mtna.2013.66 |
0.593 |
|
| 2013 |
Rungta RL, Choi HB, Lin PJ, Ko RW, Ashby D, Nair J, Manoharan M, Cullis PR, Macvicar BA. Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain. Molecular Therapy. Nucleic Acids. 2: e136. PMID 24301867 DOI: 10.1038/Mtna.2013.65 |
0.581 |
|
| 2013 |
Matsui M, Chu Y, Zhang H, Gagnon KT, Shaikh S, Kuchimanchi S, Manoharan M, Corey DR, Janowski BA. Promoter RNA links transcriptional regulation of inflammatory pathway genes. Nucleic Acids Research. 41: 10086-109. PMID 23999091 DOI: 10.1093/Nar/Gkt777 |
0.638 |
|
| 2013 |
Liu J, Pendergraff H, Narayanannair KJ, Lackey JG, Kuchimanchi S, Rajeev KG, Manoharan M, Hu J, Corey DR. RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression. Nucleic Acids Research. 41: 8788-801. PMID 23887934 DOI: 10.1093/Nar/Gkt594 |
0.648 |
|
| 2013 |
Maier MA, Jayaraman M, Matsuda S, Liu J, Barros S, Querbes W, Tam YK, Ansell SM, Kumar V, Qin J, Zhang X, Wang Q, Panesar S, Hutabarat R, Carioto M, ... ... Manoharan M, et al. Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1570-8. PMID 23799535 DOI: 10.1038/Mt.2013.124 |
0.556 |
|
| 2013 |
Prakash TP, Lima WF, Murray HM, Elbashir S, Cantley W, Foster D, Jayaraman M, Chappell AE, Manoharan M, Swayze EE, Crooke ST. Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals. Acs Chemical Biology. 8: 1402-6. PMID 23614580 DOI: 10.1021/cb4001316 |
0.627 |
|
| 2013 |
Zlatev I, Lackey JG, Zhang L, Dell A, McRae K, Shaikh S, Duncan RG, Rajeev KG, Manoharan M. Automated parallel synthesis of 5'-triphosphate oligonucleotides and preparation of chemically modified 5'-triphosphate small interfering RNA. Bioorganic & Medicinal Chemistry. 21: 722-32. PMID 23260577 DOI: 10.1016/j.bmc.2012.11.043 |
0.653 |
|
| 2013 |
Eltepu L, Jayaraman M, Rajeev KG, Manoharan M. An immobilized and reusable Cu(I) catalyst for metal ion-free conjugation of ligands to fully deprotected oligonucleotides through click reaction. Chemical Communications (Cambridge, England). 49: 184-6. PMID 23172132 DOI: 10.1039/c2cc36811k |
0.512 |
|
| 2012 |
Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, ... ... Manoharan M, et al. Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Molecular Therapy. Nucleic Acids. 1: e4. PMID 23344621 DOI: 10.1038/Mtna.2011.3 |
0.62 |
|
| 2012 |
Place RF, Wang J, Noonan EJ, Meyers R, Manoharan M, Charisse K, Duncan R, Huang V, Wang X, Li LC. Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression. Molecular Therapy. Nucleic Acids. 1: e15. PMID 23343884 DOI: 10.1038/Mtna.2012.5 |
0.629 |
|
| 2012 |
Patra A, Paolillo M, Charisse K, Manoharan M, Rozners E, Egli M. 2'-Fluoro RNA shows increased Watson-Crick H-bonding strength and stacking relative to RNA: evidence from NMR and thermodynamic data. Angewandte Chemie (International Ed. in English). 51: 11863-6. PMID 23055396 DOI: 10.1002/Anie.201204946 |
0.644 |
|
| 2012 |
Perez JT, Zlatev I, Aggarwal S, Subramanian S, Sachidanandam R, Kim B, Manoharan M, tenOever BR. A small-RNA enhancer of viral polymerase activity. Journal of Virology. 86: 13475-85. PMID 23035211 DOI: 10.1128/Jvi.02295-12 |
0.612 |
|
| 2012 |
Zlatev I, Manoharan M, Vasseur JJ, Morvan F. Solid-phase chemical synthesis of 5'-triphosphate DNA, RNA, and chemically modified oligonucleotides Current Protocols in Nucleic Acid Chemistry. PMID 22956453 DOI: 10.1002/0471142700.nc0128s50 |
0.615 |
|
| 2012 |
Shenoi RA, Narayanannair JK, Hamilton JL, Lai BF, Horte S, Kainthan RK, Varghese JP, Rajeev KG, Manoharan M, Kizhakkedathu JN. Branched multifunctional polyether polyketals: variation of ketal group structure enables unprecedented control over polymer degradation in solution and within cells. Journal of the American Chemical Society. 134: 14945-57. PMID 22906064 DOI: 10.1021/ja305080f |
0.507 |
|
| 2012 |
Kang MR, Yang G, Charisse K, Epstein-Barash H, Manoharan M, Li LC. An orthotopic bladder tumor model and the evaluation of intravesical saRNA treatment. Journal of Visualized Experiments : Jove. PMID 22872227 DOI: 10.3791/4207 |
0.526 |
|
| 2012 |
Kang MR, Yang G, Place RF, Charisse K, Epstein-Barash H, Manoharan M, Li LC. Intravesical delivery of small activating RNA formulated into lipid nanoparticles inhibits orthotopic bladder tumor growth. Cancer Research. 72: 5069-79. PMID 22869584 DOI: 10.1158/0008-5472.Can-12-1871 |
0.634 |
|
| 2012 |
Nakayama T, Butler JS, Sehgal A, Severgnini M, Racie T, Sharman J, Ding F, Morskaya SS, Brodsky J, Tchangov L, Kosovrasti V, Meys M, Nechev L, Wang G, Peng CG, ... ... Manoharan M, et al. Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1582-9. PMID 22850721 DOI: 10.1038/Mt.2012.33 |
0.604 |
|
| 2012 |
Jayaraman M, Ansell SM, Mui BL, Tam YK, Chen J, Du X, Butler D, Eltepu L, Matsuda S, Narayanannair JK, Rajeev KG, Hafez IM, Akinc A, Maier MA, Tracy MA, ... ... Manoharan M, et al. Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo Angewandte Chemie - International Edition. 51: 8529-8533. PMID 22782619 DOI: 10.1002/Anie.201203263 |
0.543 |
|
| 2012 |
Lee H, Lytton-Jean AK, Chen Y, Love KT, Park AI, Karagiannis ED, Sehgal A, Querbes W, Zurenko CS, Jayaraman M, Peng CG, Charisse K, Borodovsky A, Manoharan M, Donahoe JS, et al. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nature Nanotechnology. 7: 389-93. PMID 22659608 DOI: 10.1038/Nnano.2012.73 |
0.571 |
|
| 2012 |
Foster DJ, Barros S, Duncan R, Shaikh S, Cantley W, Dell A, Bulgakova E, O'Shea J, Taneja N, Kuchimanchi S, Sherrill CB, Akinc A, Hinkle G, Seila White AC, Pang B, ... ... Manoharan M, et al. Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo. Rna (New York, N.Y.). 18: 557-68. PMID 22294662 DOI: 10.1261/Rna.031120.111 |
0.642 |
|
| 2012 |
Jin H, Lovell JF, Chen J, Lin Q, Ding L, Ng KK, Pandey RK, Manoharan M, Zhang Z, Zheng G. Mechanistic insights into LDL nanoparticle-mediated siRNA delivery. Bioconjugate Chemistry. 23: 33-41. PMID 22142191 DOI: 10.1021/Bc200233N |
0.587 |
|
| 2012 |
Stiles DK, Zhang Z, Ge P, Nelson B, Grondin R, Ai Y, Hardy P, Nelson PT, Guzaev AP, Butt MT, Charisse K, Kosovrasti V, Tchangov L, Meys M, Maier M, ... ... Manoharan M, et al. Widespread suppression of huntingtin with convection-enhanced delivery of siRNA. Experimental Neurology. 233: 463-71. PMID 22119622 DOI: 10.1016/J.Expneurol.2011.11.020 |
0.588 |
|
| 2012 |
Krützfeldt J, Rösch N, Hausser J, Manoharan M, Zavolan M, Stoffel M. MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6. Hepatology (Baltimore, Md.). 55: 98-107. PMID 21887698 DOI: 10.1002/Hep.24658 |
0.523 |
|
| 2011 |
Alam MR, Ming X, Fisher M, Lackey JG, Rajeev KG, Manoharan M, Juliano RL. Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA. Bioconjugate Chemistry. 22: 1673-81. PMID 21755983 DOI: 10.1021/Bc200235Q |
0.615 |
|
| 2011 |
Manoharan M, Akinc A, Pandey RK, Qin J, Hadwiger P, John M, Mills K, Charisse K, Maier MA, Nechev L, Greene EM, Pallan PS, Rozners E, Rajeev KG, Egli M. Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs. Angewandte Chemie (International Ed. in English). 50: 2284-8. PMID 21351337 DOI: 10.1002/Anie.201006519 |
0.603 |
|
| 2011 |
Koller E, Vincent TM, Chappell A, De S, Manoharan M, Bennett CF. Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes. Nucleic Acids Research. 39: 4795-807. PMID 21345934 DOI: 10.1093/nar/gkr089 |
0.627 |
|
| 2011 |
Yamada T, Peng CG, Matsuda S, Addepalli H, Jayaprakash KN, Alam MR, Mills K, Maier MA, Charisse K, Sekine M, Manoharan M, Rajeev KG. Versatile site-specific conjugation of small molecules to siRNA using click chemistry. The Journal of Organic Chemistry. 76: 1198-211. PMID 21299239 DOI: 10.1021/jo101761g |
0.608 |
|
| 2011 |
Pallan PS, Greene EM, Jicman PA, Pandey RK, Manoharan M, Rozners E, Egli M. Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA. Nucleic Acids Research. 39: 3482-95. PMID 21183463 DOI: 10.1093/Nar/Gkq1270 |
0.65 |
|
| 2010 |
Matsui M, Sakurai F, Elbashir S, Foster DJ, Manoharan M, Corey DR. Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter. Chemistry & Biology. 17: 1344-55. PMID 21168770 DOI: 10.1016/J.Chembiol.2010.10.009 |
0.635 |
|
| 2010 |
Jayaprakash KN, Peng CG, Butler D, Varghese JP, Maier MA, Rajeev KG, Manoharan M. Non-nucleoside building blocks for copper-assisted and copper-free click chemistry for the efficient synthesis of RNA conjugates. Organic Letters. 12: 5410-3. PMID 21049912 DOI: 10.1021/ol102205j |
0.597 |
|
| 2010 |
Addepalli H, Meena, Peng CG, Wang G, Fan Y, Charisse K, Jayaprakash KN, Rajeev KG, Pandey RK, Lavine G, Zhang L, Jahn-Hofmann K, Hadwiger P, Manoharan M, Maier MA. Modulation of thermal stability can enhance the potency of siRNA. Nucleic Acids Research. 38: 7320-31. PMID 20610434 DOI: 10.1093/nar/gkq568 |
0.633 |
|
| 2010 |
Kretschmer M, Lavine G, McArdle J, Kuchimanchi S, Murugaiah V, Manoharan M. An automated algorithm for sequence confirmation of chemically modified oligonucleotides by tandem mass spectrometry. Analytical Biochemistry. 405: 213-23. PMID 20599656 DOI: 10.1016/j.ab.2010.06.023 |
0.505 |
|
| 2010 |
Perez JT, Varble A, Sachidanandam R, Zlatev I, Manoharan M, García-Sastre A, tenOever BR. Influenza A virus-generated small RNAs regulate the switch from transcription to replication. Proceedings of the National Academy of Sciences of the United States of America. 107: 11525-30. PMID 20534471 DOI: 10.1073/pnas.1001984107 |
0.592 |
|
| 2010 |
Akinc A, Querbes W, De S, Qin J, Frank-Kamenetsky M, Jayaprakash KN, Jayaraman M, Rajeev KG, Cantley WL, Dorkin JR, Butler JS, Qin L, Racie T, Sprague A, Fava E, ... ... Manoharan M, et al. Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1357-64. PMID 20461061 DOI: 10.1038/Mt.2010.85 |
0.6 |
|
| 2010 |
Zlatev I, Lavergne T, Debart F, Vasseur JJ, Manoharan M, Morvan F. Efficient solid-phase chemical synthesis of 5'-triphosphates of DNA, RNA, and their analogues. Organic Letters. 12: 2190-3. PMID 20420425 DOI: 10.1021/Ol1004214 |
0.603 |
|
| 2010 |
Watts JK, Yu D, Charisse K, Montaillier C, Potier P, Manoharan M, Corey DR. Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters. Nucleic Acids Research. 38: 5242-59. PMID 20403811 DOI: 10.1093/Nar/Gkq258 |
0.659 |
|
| 2010 |
Chen Q, Butler D, Querbes W, Pandey RK, Ge P, Maier MA, Zhang L, Rajeev KG, Nechev L, Kotelianski V, Manoharan M, Sah DW. Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 144: 227-32. PMID 20170694 DOI: 10.1016/j.jconrel.2010.02.011 |
0.636 |
|
| 2010 |
Murugaiah V, Zedalis W, Lavine G, Charisse K, Manoharan M. Reversed-phase high-performance liquid chromatography method for simultaneous analysis of two liposome-formulated short interfering RNA duplexes. Analytical Biochemistry. 401: 61-7. PMID 20156415 DOI: 10.1016/j.ab.2010.02.012 |
0.557 |
|
| 2010 |
Semple SC, Akinc A, Chen J, Sandhu AP, Mui BL, Cho CK, Sah DW, Stebbing D, Crosley EJ, Yaworski E, Hafez IM, Dorkin JR, Qin J, Lam K, Rajeev KG, ... ... Manoharan M, et al. Rational design of cationic lipids for siRNA delivery. Nature Biotechnology. 28: 172-6. PMID 20081866 DOI: 10.1038/Nbt.1602 |
0.575 |
|
| 2009 |
Alvarez R, Elbashir S, Borland T, Toudjarska I, Hadwiger P, John M, Roehl I, Morskaya SS, Martinello R, Kahn J, Van Ranst M, Tripp RA, DeVincenzo JP, Pandey R, Maier M, ... ... Manoharan M, et al. RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy. Antimicrobial Agents and Chemotherapy. 53: 3952-62. PMID 19506055 DOI: 10.1128/AAC.00014-09 |
0.622 |
|
| 2009 |
Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M. A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution. Chemical Communications (Cambridge, England). 2017-9. PMID 19333476 DOI: 10.1039/B822781K |
0.594 |
|
| 2009 |
Akinc A, Goldberg M, Qin J, Dorkin JR, Gamba-Vitalo C, Maier M, Jayaprakash KN, Jayaraman M, Rajeev KG, Manoharan M, Koteliansky V, Röhl I, Leshchiner ES, Langer R, Anderson DG. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 872-9. PMID 19259063 DOI: 10.1038/Mt.2009.36 |
0.619 |
|
| 2009 |
Wu Y, Navarro F, Lal A, Basar E, Pandey RK, Manoharan M, Feng Y, Lee SJ, Lieberman J, Palliser D. Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host & Microbe. 5: 84-94. PMID 19154990 DOI: 10.1016/J.Chom.2008.12.003 |
0.58 |
|
| 2009 |
Querbes W, Ge P, Zhang W, Fan Y, Costigan J, Charisse K, Maier M, Nechev L, Manoharan M, Kotelianski V, Sah DWY. Direct CNS delivery of siRNA mediates robust silencing in oligodendrocytes. Oligonucleotides. 19: 23-29. PMID 19093781 DOI: 10.1089/Oli.2008.0165 |
0.661 |
|
| 2008 |
Frank-Kamenetsky M, Grefhorst A, Anderson NN, Racie TS, Bramlage B, Akinc A, Butler D, Charisse K, Dorkin R, Fan Y, Gamba-Vitalo C, Hadwiger P, Jayaraman M, John M, Jayaprakash KN, ... ... Manoharan M, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America. 105: 11915-20. PMID 18695239 DOI: 10.1073/Pnas.0805434105 |
0.576 |
|
| 2008 |
Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, Bacallado SA, Nguyen DN, Fuller J, Alvarez R, Borodovsky A, Borland T, Constien R, de Fougerolles A, Dorkin JR, ... ... Manoharan M, et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nature Biotechnology. 26: 561-9. PMID 18438401 DOI: 10.1038/Nbt1402 |
0.664 |
|
| 2008 |
Prakash TP, Kawasaki AM, Wancewicz EV, Shen L, Monia BP, Ross BS, Bhat B, Manoharan M. Comparing in vitro and in vivo activity of 2'-O-[2-(methylamino)-2-oxoethyl]- and 2'-O-methoxyethyl-modified antisense oligonucleotides. Journal of Medicinal Chemistry. 51: 2766-76. PMID 18399648 DOI: 10.1021/jm701537z |
0.539 |
|
| 2007 |
Gottwein E, Mukherjee N, Sachse C, Frenzel C, Majoros WH, Chi JT, Braich R, Manoharan M, Soutschek J, Ohler U, Cullen BR. A viral microRNA functions as an orthologue of cellular miR-155. Nature. 450: 1096-9. PMID 18075594 DOI: 10.1038/Nature05992 |
0.516 |
|
| 2007 |
John M, Constien R, Akinc A, Goldberg M, Moon YA, Spranger M, Hadwiger P, Soutschek J, Vornlocher HP, Manoharan M, Stoffel M, Langer R, Anderson DG, Horton JD, Koteliansky V, et al. Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway. Nature. 449: 745-7. PMID 17898712 DOI: 10.1038/Nature06179 |
0.606 |
|
| 2007 |
Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M. Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Research. 35: 6424-38. PMID 17881374 DOI: 10.1093/Nar/Gkm664 |
0.634 |
|
| 2007 |
Wolfrum C, Shi S, Jayaprakash KN, Jayaraman M, Wang G, Pandey RK, Rajeev KG, Nakayama T, Charrise K, Ndungo EM, Zimmermann T, Koteliansky V, Manoharan M, Stoffel M. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nature Biotechnology. 25: 1149-57. PMID 17873866 DOI: 10.1038/Nbt1339 |
0.589 |
|
| 2007 |
Krützfeldt J, Kuwajima S, Braich R, Rajeev KG, Pena J, Tuschl T, Manoharan M, Stoffel M. Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Research. 35: 2885-92. PMID 17439965 DOI: 10.1093/Nar/Gkm024 |
0.545 |
|
| 2007 |
Li QJ, Chau J, Ebert PJ, Sylvester G, Min H, Liu G, Braich R, Manoharan M, Soutschek J, Skare P, Klein LO, Davis MM, Chen CZ. miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell. 129: 147-61. PMID 17382377 DOI: 10.1016/J.Cell.2007.03.008 |
0.485 |
|
| 2007 |
Prakash TP, Püschl A, Manoharan M. N,N'-Bis-(2-(cyano)ethoxycarbonyl)-2-methyl-2-thiopseudourea: a guanylating reagent for synthesis of 2'-O-[2-(Guanidinium)ethyl]-modified oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids. 26: 149-59. PMID 17365794 DOI: 10.1080/15257770601112705 |
0.515 |
|
| 2006 |
Xia J, Noronha A, Toudjarska I, Li F, Akinc A, Braich R, Frank-Kamenetsky M, Rajeev KG, Egli M, Manoharan M. Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide. Acs Chemical Biology. 1: 176-83. PMID 17163665 DOI: 10.1021/Cb600063P |
0.655 |
|
| 2006 |
Bumcrot D, Manoharan M, Koteliansky V, Sah DW. RNAi therapeutics: a potential new class of pharmaceutical drugs. Nature Chemical Biology. 2: 711-9. PMID 17108989 DOI: 10.1038/nchembio839 |
0.586 |
|
| 2006 |
Maier MA, Esau CC, Siwkowski AM, Wancewicz EV, Albertshofer K, Kinberger GA, Kadaba NS, Watanabe T, Manoharan M, Bennett CF, Griffey RH, Swayze EE. Evaluation of basic amphipathic peptides for cellular delivery of antisense peptide nucleic acids. Journal of Medicinal Chemistry. 49: 2534-42. PMID 16610796 DOI: 10.1021/jm051275y |
0.533 |
|
| 2006 |
Li F, Sarkhel S, Wilds CJ, Wawrzak Z, Prakash TP, Manoharan M, Egli M. 2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H. Biochemistry. 45: 4141-52. PMID 16566588 DOI: 10.1021/Bi052322R |
0.629 |
|
| 2006 |
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, Judge AD, Lam K, McClintock K, Nechev LV, Palmer LR, ... ... Manoharan M, et al. RNAi-mediated gene silencing in non-human primates. Nature. 441: 111-4. PMID 16565705 DOI: 10.1038/nature04688 |
0.653 |
|
| 2005 |
Krützfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M. Silencing of microRNAs in vivo with 'antagomirs' Nature. 438: 685-689. PMID 16258535 DOI: 10.1038/Nature04303 |
0.527 |
|
| 2005 |
Albertshofer K, Siwkowski AM, Wancewicz EV, Esau CC, Watanabe T, Nishihara KC, Kinberger GA, Malik L, Eldrup AB, Manoharan M, Geary RS, Monia BP, Swayze EE, Griffey RH, Bennett CF, et al. Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid. Journal of Medicinal Chemistry. 48: 6741-9. PMID 16220989 DOI: 10.1021/jm050490b |
0.538 |
|
| 2005 |
Diop-Frimpong B, Prakash TP, Rajeev KG, Manoharan M, Egli M. Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines. Nucleic Acids Research. 33: 5297-307. PMID 16170156 DOI: 10.1093/Nar/Gki823 |
0.639 |
|
| 2005 |
Egli M, Minasov G, Tereshko V, Pallan PS, Teplova M, Inamati GB, Lesnik EA, Owens SR, Ross BS, Prakash TP, Manoharan M. Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications. Biochemistry. 44: 9045-57. PMID 15966728 DOI: 10.1021/Bi050574M |
0.647 |
|
| 2005 |
Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nature Medicine. 11: 263-70. PMID 15723075 DOI: 10.1038/nm1191 |
0.599 |
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| 2005 |
de Fougerolles A, Manoharan M, Meyers R, Vornlocher HP. RNA interference in vivo: toward synthetic small inhibitory RNA-based therapeutics. Methods in Enzymology. 392: 278-96. PMID 15644187 DOI: 10.1016/S0076-6879(04)92016-2 |
0.645 |
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| 2005 |
Manoharan M. RNA interference and chemically modified small interfering RNAs. Current Opinion in Chemical Biology. 8: 570-9. PMID 15556399 DOI: 10.1016/j.cbpa.2004.10.007 |
0.65 |
|
| 2004 |
Rogers FA, Manoharan M, Rabinovitch P, Ward DC, Glazer PM. Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides. Nucleic Acids Research. 32: 6595-604. PMID 15602001 DOI: 10.1093/Nar/Gkh998 |
0.555 |
|
| 2004 |
Pattanayek R, Sethaphong L, Pan C, Prhavc M, Prakash TP, Manoharan M, Egli M. Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues. Journal of the American Chemical Society. 126: 15006-7. PMID 15547979 DOI: 10.1021/Ja044637K |
0.617 |
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| 2004 |
Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, Elbashir S, Geick A, Hadwiger P, Harborth J, John M, Kesavan V, Lavine G, Pandey RK, Racie T, ... ... Manoharan M, et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature. 432: 173-8. PMID 15538359 DOI: 10.1038/nature03121 |
0.558 |
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| 2004 |
Graham IR, Hill VJ, Manoharan M, Inamati GB, Dickson G. Towards a therapeutic inhibition of dystrophin exon 23 splicing in mdx mouse muscle induced by antisense oligoribonucleotides (splicomers): target sequence optimisation using oligonucleotide arrays. The Journal of Gene Medicine. 6: 1149-58. PMID 15386737 DOI: 10.1002/jgm.603 |
0.621 |
|
| 2004 |
Maier MA, Choi Y, Gaus H, Barchi JJ, Marquez VE, Manoharan M. Synthesis and characterization of oligonucleotides containing conformationally constrained bicyclo[3.1.0]hexane pseudosugar analogs Nucleic Acids Research. 32: 3642-3650. PMID 15247346 DOI: 10.1093/Nar/Gkh667 |
0.511 |
|
| 2004 |
Prakash TP, Püschl A, Lesnik E, Mohan V, Tereshko V, Egli M, Manoharan M. 2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures. Organic Letters. 6: 1971-4. PMID 15176796 DOI: 10.1021/Ol049470E |
0.577 |
|
| 2004 |
Prakash TP, Johnston JF, Graham MJ, Condon TP, Manoharan M. 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo. Nucleic Acids Research. 32: 828-33. PMID 14762210 DOI: 10.1093/nar/gkh220 |
0.57 |
|
| 2003 |
Manoharan M. RNA interference and chemically modified siRNAs. Nucleic Acids Research. Supplement (2001). 115-6. PMID 14510407 DOI: 10.1093/nass/3.1.115 |
0.65 |
|
| 2003 |
Shen L, Siwkowski A, Wancewicz EV, Lesnik E, Butler M, Witchell D, Vasquez G, Ross B, Acevedo O, Inamati G, Sasmor H, Manoharan M, Monia BP. Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo. Antisense & Nucleic Acid Drug Development. 13: 129-42. PMID 12954113 DOI: 10.1089/108729003768247592 |
0.616 |
|
| 2003 |
Rajeev KG, Prakash TP, Manoharan M. 2'-modified-2-thiothymidine oligonucleotides. Organic Letters. 5: 3005-8. PMID 12916967 DOI: 10.1021/ol0348607 |
0.601 |
|
| 2003 |
Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M. 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects. Organic Letters. 5: 2017-20. PMID 12790517 DOI: 10.1021/Ol0340991 |
0.561 |
|
| 2003 |
Polak M, Manoharan M, Inamati GB, Plavec J. Tuning of conformational preorganization in model 2',5'- and 3',5'-linked oligonucleotides by 3'- and 2'-O-methoxyethyl modification. Nucleic Acids Research. 31: 2066-76. PMID 12682357 DOI: 10.1093/nar/gkg305 |
0.499 |
|
| 2003 |
Guzaev AP, Manoharan M. A conformationally preorganized universal solid support for efficient oligonucleotide synthesis. Journal of the American Chemical Society. 125: 2380-1. PMID 12603111 DOI: 10.1021/ja0284613 |
0.535 |
|
| 2003 |
Prakash TP, Kawasaki AM, Lesnik EA, Owens SR, Manoharan M. 2'-O-[2-(amino)-2-oxoethyl] oligonucleotides. Organic Letters. 5: 403-6. PMID 12583729 DOI: 10.1021/ol027131k |
0.5 |
|
| 2003 |
Maier MA, Yannopoulos CG, Mohamed N, Roland A, Fritz H, Mohan V, Just G, Manoharan M. Synthesis of antisense oligonucleotides conjugated to a multivalent carbohydrate cluster for cellular targeting. Bioconjugate Chemistry. 14: 18-29. PMID 12526688 DOI: 10.1021/Bc020028V |
0.571 |
|
| 2003 |
't Hoen PA, Out R, Commandeur JN, Vermeulen NP, van Batenburg FH, Manoharan M, van Berkel TJ, Biessen EA, Bijsterbosch MK. Selection of antisense oligodeoxynucleotides against glutathione S-transferase Mu. Rna (New York, N.Y.). 8: 1572-83. PMID 12515389 |
0.611 |
|
| 2003 |
Manoharan M, Inamati GB, Lesnik EA, Sioufi NB, Freier SM. Improving antisense oligonucleotide binding to human serum albumin: dramatic effect of ibuprofen conjugation. Chembiochem : a European Journal of Chemical Biology. 3: 1257-60. PMID 12465035 DOI: 10.1002/1439-7633(20021202)3:12<1257::AID-CBIC1257>3.0.CO;2-2 |
0.518 |
|
| 2003 |
Manoharan M. Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action. Antisense & Nucleic Acid Drug Development. 12: 103-28. PMID 12074364 DOI: 10.1089/108729002760070849 |
0.558 |
|
| 2002 |
Wilds CJ, Maier MA, Tereshko V, Manoharan M, Egli M. Direct observation of a cytosine analogue that forms five hydrogen bonds to guanosine: guanidino G-clamp. Angewandte Chemie (International Ed. in English). 41: 115-7. PMID 12491456 DOI: 10.1002/1521-3773(20020104)41:1<115::Aid-Anie115>3.0.Co;2-R |
0.504 |
|
| 2002 |
Rajeev KG, Maier MA, Lesnik EA, Manoharan M. High-affinity peptide nucleic acid oligomers containing tricyclic cytosine analogues. Organic Letters. 4: 4395-8. PMID 12465896 DOI: 10.1021/ol027026a |
0.586 |
|
| 2002 |
Sazani P, Gemignani F, Kang SH, Maier MA, Manoharan M, Persmark M, Bortner D, Kole R. Systemically delivered antisense oligomers upregulate gene expression in mouse tissues. Nature Biotechnology. 20: 1228-33. PMID 12426578 DOI: 10.1038/Nbt759 |
0.574 |
|
| 2002 |
Prakash TP, Manoharan M, Kawasaki AM, Fraser AS, Lesnik EA, Sioufi N, Leeds JM, Teplova M, Egli M. 2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA. Biochemistry. 41: 11642-8. PMID 12269806 DOI: 10.1021/Bi020264T |
0.574 |
|
| 2002 |
Bijsterbosch MK, Manoharan M, Dorland R, Van Veghel R, Biessen EA, Van Berkel TJ. bis-Cholesteryl-conjugated phosphorothioate oligodeoxynucleotides are highly selectively taken up by the liver. The Journal of Pharmacology and Experimental Therapeutics. 302: 619-26. PMID 12130724 DOI: 10.1124/jpet.302.2.619 |
0.528 |
|
| 2002 |
't Hoen PA, Rosema BS, Commandeur JN, Vermeulen NP, Manoharan M, van Berkel TJ, Biessen EA, Bijsterbosch MK. Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression. European Journal of Biochemistry. 269: 2574-83. PMID 12027896 DOI: 10.1046/J.1432-1033.2002.02924.X |
0.539 |
|
| 2002 |
Maier MA, Leeds JM, Balow G, Springer RH, Bharadwaj R, Manoharan M. Nuclease resistance of oligonucleotides containing the tricyclic cytosine analogues phenoxazine and 9-(2-aminoethoxy)-phenoxazine ("G-clamp") and origins of their nuclease resistance properties. Biochemistry. 41: 1323-7. PMID 11802733 DOI: 10.1021/bi011725y |
0.576 |
|
| 2002 |
Prakash TP, Kawasaki AM, Fraser AS, Vasquez G, Manoharan M. Synthesis of 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides. The Journal of Organic Chemistry. 67: 357-69. PMID 11798305 |
0.564 |
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