Jean Bennett, MD PhD - Publications

Affiliations: 
Ophthalmology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Ocular Gene Therapy
Website:
http://www.med.upenn.edu/apps/faculty/index.php/g327/p11214

227 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Bennett J, Maguire AM. Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl. Cold Spring Harbor Perspectives in Medicine. PMID 36167727 DOI: 10.1101/cshperspect.a041307  0.347
2022 Isgrig K, Ishibashi Y, Lee HJ, Zhu J, Grati M, Bennett J, Griffith AJ, Roux I, Chien WW. AAV8BP2 and AAV8 transduce the mammalian cochlear lateral wall and endolymphatic sac with high efficiency. Molecular Therapy. Methods & Clinical Development. 26: 371-383. PMID 36034771 DOI: 10.1016/j.omtm.2022.07.013  0.32
2022 Aleman TS, Huckfeldt RM, Serrano LW, Pearson DJ, Vergilio GK, McCague S, Marshall KA, Ashtari M, Doan TM, Weigel-DiFranco CA, Biron BS, Wen XH, Chung DC, Liu E, Ferenchak K, ... ... Bennett J, et al. AAV2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial. Ophthalmology. PMID 35714735 DOI: 10.1016/j.ophtha.2022.06.006  0.774
2022 Nikonov S, Aravand P, Lyubarsky A, Nikonov R, Luo AJ, Wei Z, Maguire AM, Phelps NT, Shpylchak I, Willett K, Aleman TS, Huckfeldt RM, Ramachandran PS, Bennett J. Restoration of Vision and Retinal Responses After Adeno-Associated Virus-Mediated Optogenetic Therapy in Blind Dogs. Translational Vision Science & Technology. 11: 24. PMID 35604672 DOI: 10.1167/tvst.11.5.24  0.86
2022 Morgan JIW, Jiang YY, Vergilio GK, Serrano LW, Pearson DJ, Bennett J, Maguire AM, Aleman TS. Short-term Assessment of Subfoveal Injection of Adeno-Associated Virus-Mediated hCHM Gene Augmentation in Choroideremia Using Adaptive Optics Ophthalmoscopy. Jama Ophthalmology. PMID 35266957 DOI: 10.1001/jamaophthalmol.2022.0158  0.46
2021 Argyriou C, Polosa A, Song JY, Omri S, Steele B, Cécyre B, McDougald DS, Di Pietro E, Bouchard JF, Bennett J, Hacia JG, Lachapelle P, Braverman NE. AAV-mediated gene augmentation improves visual function in the PEX1-Gly844Asp mouse model for mild Zellweger spectrum disorder. Molecular Therapy. Methods & Clinical Development. 23: 225-240. PMID 34703844 DOI: 10.1016/j.omtm.2021.09.002  0.861
2021 Maguire AM, Russell S, Chung DC, Yu ZF, Tillman A, Drack AV, Simonelli F, Leroy BP, Reape KZ, High KA, Bennett J. Durability of Voretigene Neparvovec for Biallelic RPE65-Mediated Inherited Retinal Disease: Phase 3 Results at 3 Years and 4 Years. Ophthalmology. PMID 33798654 DOI: 10.1016/j.ophtha.2021.03.031  0.591
2021 Aleman TS, O'Neil EC, O'Connor K, Jiang YY, Aleman IA, Bennett J, Morgan JIW, Toussaint BW. Bardet-Biedl syndrome-7 () shows treatment potential and a cone-rod dystrophy phenotype that recapitulates the non-human primate model. Ophthalmic Genetics. 1-14. PMID 33729075 DOI: 10.1080/13816810.2021.1888132  0.384
2021 Aleman TS, Miller AJ, Maguire KH, Aleman EM, Serrano LW, O'Connor KB, Bedoukian EC, Leroy BP, Maguire AM, Bennett J. A Virtual Reality Orientation and Mobility Test for Inherited Retinal Degenerations: Testing a Proof-of-Concept After Gene Therapy. Clinical Ophthalmology (Auckland, N.Z.). 15: 939-952. PMID 33688162 DOI: 10.2147/OPTH.S292527  0.316
2021 Ross AG, McDougald DS, Khan RS, Duong TT, Dine KE, Aravand P, Bennett J, Chavali VRM, Shindler KS. Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1. Gene Therapy. PMID 33589779 DOI: 10.1038/s41434-021-00219-z  0.834
2020 Maguire AM, Bennett J, Aleman EM, Leroy BP, Aleman TS. Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33278565 DOI: 10.1016/j.ymthe.2020.11.029  0.38
2020 Uyhazi KE, Bennett J. A CRISPR view of the 2020 Nobel Prize in Chemistry. The Journal of Clinical Investigation. PMID 33201862 DOI: 10.1172/JCI145214  0.752
2020 Morales L, Gambhir Y, Bennett J, Stedman HH. Broader Implications of Progressive Liver Dysfunction and Lethal Sepsis in Two Boys following Systemic High-Dose AAV. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 32710826 DOI: 10.1016/J.Ymthe.2020.07.009  0.761
2020 Mowad TG, Willett AE, Mahmoudian M, Lipin M, Heinecke A, Maguire AM, Bennett J, Ashtari M. Compensatory Cross-Modal Plasticity Persists After Sight Restoration. Frontiers in Neuroscience. 14: 291. PMID 32477041 DOI: 10.3389/Fnins.2020.00291  0.326
2020 Uyhazi KE, Aravand P, Bell BA, Wei Z, Leo L, Serrano LW, Pearson DJ, Shpylchak I, Pham J, Vasireddy V, Bennett J, Aleman TS. Treatment Potential for LCA5-Associated Leber Congenital Amaurosis. Investigative Ophthalmology & Visual Science. 61: 30. PMID 32428231 DOI: 10.1167/Iovs.61.5.30  0.797
2019 Shakhmantsir I, Dooley SJ, Kishore S, Chen D, Pierce E, Bennett J, Sehgal A. RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation. Journal of Biological Rhythms. 748730419887876. PMID 31726916 DOI: 10.1177/0748730419887876  0.841
2019 Weed L, Ammar MJ, Zhou S, Wei Z, Serrano LW, Sun J, Lee V, Maguire AM, Bennett J, Aleman TS. Safety of Same-Eye Subretinal Sequential Readministration of in Non-human Primates. Molecular Therapy. Methods & Clinical Development. 15: 133-148. PMID 31660416 DOI: 10.1016/J.Omtm.2019.08.011  0.827
2019 Yang U, Gentleman S, Gai X, Gorin MB, Borchert MS, Lee TC, Villanueva A, Koenekoop R, Maguire AM, Bennett J, Redmond TM, Nagiel A. Utility of In Vitro Mutagenesis of RPE65 Protein for Verification of Mutational Pathogenicity Before Gene Therapy. Jama Ophthalmology. 1-9. PMID 31580392 DOI: 10.1001/Jamaophthalmol.2019.3914  0.4
2019 Maguire AM, Russell S, Wellman JA, Chung DC, Yu ZF, Tillman A, Wittes J, Pappas J, Elci O, Marshall KA, McCague S, Reichert H, Davis M, Simonelli F, Leroy BP, ... ... Bennett J, et al. Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials. Ophthalmology. 126: 1273-1285. PMID 31443789 DOI: 10.1016/J.Ophtha.2019.06.017  0.635
2019 Tuten WS, Vergilio GK, Young GJ, Bennett J, Maguire AM, Aleman TS, Brainard DH, Morgan JIW. Visual Function at the Atrophic Border in Choroideremia Assessed with Adaptive Optics Microperimetry. Ophthalmology. Retina. PMID 31235310 DOI: 10.1016/J.Oret.2019.05.002  0.785
2019 O'Neil E, Serrano L, Scoles D, Cunningham KE, Han G, Chiang J, Bennett J, Aleman TS. Detailed retinal phenotype of Boucher-Neuhäuser syndrome associated with mutations in mimicking choroideremia. Ophthalmic Genetics. 1-9. PMID 31135245 DOI: 10.1080/13816810.2019.1605392  0.495
2019 McDougald DS, Papp TE, Zezulin AU, Zhou S, Bennett J. AKT3 Gene Transfer Promotes Anabolic Reprogramming and Photoreceptor Neuroprotection in a Pre-clinical Model of Retinitis Pigmentosa. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31043342 DOI: 10.1016/J.Ymthe.2019.04.009  0.856
2019 McDougald DS, Duong TT, Palozola KC, Marsh A, Papp TE, Mills JA, Zhou S, Bennett J. CRISPR Activation Enhances Potency of AAV Vectors Driven by Tissue-Specific Promoters. Molecular Therapy. Methods & Clinical Development. 13: 380-389. PMID 31024980 DOI: 10.1016/J.Omtm.2019.03.004  0.795
2019 Pennesi ME, Birch DG, Duncan JL, Bennett J, Girach A. CHOROIDEREMIA: Retinal Degeneration With an Unmet Need. Retina (Philadelphia, Pa.). PMID 31021898 DOI: 10.1097/Iae.0000000000002553  0.516
2019 Duong TT, Lim J, Vasireddy V, Papp T, Nguyen H, Leo L, Pan J, Zhou S, Chen HI, Bennett J, Mills JA. Comparative AAV-eGFP Transgene Expression Using Vector Serotypes 1-9, 7m8, and 8b in Human Pluripotent Stem Cells, RPEs, and Human and Rat Cortical Neurons. Stem Cells International. 2019: 7281912. PMID 30800164 DOI: 10.1155/2019/7281912  0.81
2019 Isgrig K, McDougald DS, Zhu J, Wang HJ, Bennett J, Chien WW. AAV2.7m8 is a powerful viral vector for inner ear gene therapy. Nature Communications. 10: 427. PMID 30683875 DOI: 10.1038/S41467-018-08243-1  0.814
2019 Uyhazi KE, Bennett J. Blinded by the light: a nonhuman primate model of achromatopsia. The Journal of Clinical Investigation. PMID 30667378 DOI: 10.1172/Jci126205  0.844
2019 Drack AV, Bennett J, Russell S, High KA, Yu Z, Tillman A, Chung D, Reape KZ, Ciulla T, Maguire A. How long does gene therapy last? 4-year follow-up of phase 3 voretigene neparvovec trial in RPE65-associated LCA/inherited retinal disease Journal of Aapos. 23. DOI: 10.1016/J.Jaapos.2019.08.018  0.476
2018 Sochor MA, Vasireddy V, Drivas TG, Wojno A, Duong TT, Shpylchak I, Bennicelli J, Chung D, Bennett J, Lewis M. Author Correction: An Autogenously Regulated Expression System for Gene Therapeutic Ocular Applications. Scientific Reports. 8: 17286. PMID 30470797 DOI: 10.1038/S41598-018-35960-W  0.774
2018 Aleman TS, Uyhazi KE, Serrano LW, Vasireddy V, Bowman SJ, Ammar MJ, Pearson DJ, Maguire AM, Bennett J. RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function. Investigative Ophthalmology & Visual Science. 59: 5225-5236. PMID 30372751 DOI: 10.1167/Iovs.18-24708  0.833
2018 Dooley SJ, McDougald DS, Fisher KJ, Bennicelli JL, Mitchell LG, Bennett J. Spliceosome-Mediated Pre-mRNA trans-Splicing Can Repair CEP290 mRNA. Molecular Therapy. Nucleic Acids. 12: 294-308. PMID 30195768 DOI: 10.1016/J.Omtn.2018.05.014  0.842
2018 Bryant L, Lozynska O, Marsh A, Papp TE, van Gorder L, Serrano LW, Gai X, Maguire AM, Aleman TS, Bennett J. Identification of a novel pathogenic missense mutation in using whole exome sequencing: a case report. The British Journal of Ophthalmology. PMID 30030392 DOI: 10.1136/Bjophthalmol-2017-311405  0.723
2018 Silson EH, Aleman TS, Willett A, Serrano LW, Pearson DJ, Rauschecker AM, Maguire AM, Baker CI, Bennett J, Ashtari M. Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia. Investigative Ophthalmology & Visual Science. 59: 3249-3258. PMID 29971442 DOI: 10.1167/Iovs.18-23929  0.453
2018 Song JY, Aravand P, Nikonov S, Leo L, Lyubarsky A, Bennicelli JL, Pan J, Wei Z, Shpylchak I, Herrera P, Bennett DJ, Commins N, Maguire AM, Pham J, den Hollander AI, ... ... Bennett J, et al. Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29673930 DOI: 10.1016/J.Ymthe.2018.03.015  0.845
2018 McDougald DS, Dine KE, Zezulin AU, Bennett J, Shindler KS. SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. Investigative Ophthalmology & Visual Science. 59: 1212-1220. PMID 29494741 DOI: 10.1167/Iovs.17-22972  0.831
2018 Duong TT, Vasireddy V, Ramachandran P, Herrera PS, Leo L, Merkel C, Bennett J, Mills JA. Use of induced pluripotent stem cell models to probe the pathogenesis of Choroideremia and to develop a potential treatment. Stem Cell Research. 27: 140-150. PMID 29414605 DOI: 10.1016/J.Scr.2018.01.009  0.849
2018 Bryant L, Lozynska O, Maguire AM, Aleman TS, Bennett J. Prescreening whole exome sequencing results from patients with retinal degeneration for variants in genes associated with retinal degeneration. Clinical Ophthalmology (Auckland, N.Z.). 12: 49-63. PMID 29343940 DOI: 10.2147/Opth.S147684  0.766
2018 Argyriou C, Song JY, Polosa A, Cecyre B, Bouchard J, Lachapelle P, Bennett J, Braverman N. AB037. rAAV mediated PEX1 gene augmentation improves visual function in a mouse model for Zellweger spectrum disorder Annals of Eye Science. 3: AB037-AB037. DOI: 10.21037/Aes.2018.Ab037  0.371
2018 Russell S, Bennett J, Maguire AM, High KA. Voretigene neparvovec-rzyl for the treatment of biallelic RPE65 mutation–associated retinal dystrophy Expert Opinion On Orphan Drugs. 6: 457-464. DOI: 10.1080/21678707.2018.1508340  0.435
2018 Drack AV, Bennett J, Russell S, Wellman JA, Chung DC, High KA, Yu Z, Maguire AM. Year 3 results and age-stratified analyses for a phase 3 trial of voretigene neparvovec in RPE65 mutation-associated inherited retinal disease Journal of American Association For Pediatric Ophthalmology and Strabismus. 22: e13. DOI: 10.1016/J.Jaapos.2018.07.039  0.399
2017 Carvalho LS, Turunen HT, Wassmer SJ, Luna-Velez MV, Xiao R, Bennett J, Vandenberghe LH. Evaluating Efficiencies of Dual AAV Approaches for Retinal Targeting. Frontiers in Neuroscience. 11: 503. PMID 28943836 DOI: 10.3389/Fnins.2017.00503  0.846
2017 Bryant L, Lozynska O, Han G, Morgan JIW, Gai X, Maguire AM, Aleman T, Bennett J. On variants and disease-causing mutations: Case studies of a SEMA4A variant identified in inherited blindness. Ophthalmic Genetics. 1-3. PMID 28805479 DOI: 10.1080/13816810.2017.1354384  0.773
2017 Russell S, Bennett J, Wellman JA, Chung DC, Yu ZF, Tillman A, Wittes J, Pappas J, Elci O, McCague S, Cross D, Marshall KA, Walshire J, Kehoe TL, Reichert H, et al. Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. Lancet (London, England). PMID 28712537 DOI: 10.1016/S0140-6736(17)31868-8  0.636
2017 Chung DC, McCague S, Yu ZF, Thill S, DiStefano-Pappas J, Bennett J, Cross D, Marshall K, Wellman J, High KA. Novel mobility test to assess functional vision in patients with inherited retinal dystrophies. Clinical & Experimental Ophthalmology. PMID 28697537 DOI: 10.1111/Ceo.13022  0.628
2017 Aravand P, Ramachandran PS, Schpylchak I, Phelps NT, Nikonov S, Bennett J. Protocols for Visually Guided Navigation Assessment of Efficacy of Retina-Directed Cell or Gene Therapy in Canines. Frontiers in Neuroscience. 11: 215. PMID 28491015 DOI: 10.3389/Fnins.2017.00215  0.799
2017 Bennett J. Taking Stock of Retinal Gene Therapy: Looking Back and Moving Forward. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28391961 DOI: 10.1016/J.Ymthe.2017.03.008  0.478
2017 Ashtari M, Nikonova ES, Marshall KA, Young GJ, Aravand P, Pan W, Ying GS, Willett AE, Mahmoudian M, Maguire AM, Bennett J. The Role of the Human Visual Cortex in Assessment of the Long-Term Durability of Retinal Gene Therapy in Follow-on RPE65 Clinical Trial Patients. Ophthalmology. PMID 28237426 DOI: 10.1016/J.Ophtha.2017.01.029  0.455
2016 Aleman TS, Han G, Serrano LW, Fuerst NM, Charlson ES, Pearson DJ, Chung DC, Traband A, Pan W, Ying GS, Bennett J, Maguire AM, Morgan JI. Natural History of the Central Structural Abnormalities in Choroideremia: A Prospective Cross-Sectional Study. Ophthalmology. PMID 27986385 DOI: 10.1016/J.Ophtha.2016.10.022  0.675
2016 Ramachandran P, Lee V, Wei Z, Song JY, Casal G, Cronin T, Willett K, Huckfeldt R, Morgan JI, Aleman TS, Maguire AM, Bennett J. Evaluation of dose and safety of AAV7m8 and AAV8BP2 in the non-human primate retina. Human Gene Therapy. PMID 27750461 DOI: 10.1089/hum.2016.111  0.826
2016 MacLaren RE, Bennett J, Schwartz SD. Gene Therapy and Stem Cell Transplantation in Retinal Disease: The New Frontier. Ophthalmology. 123: S98-S106. PMID 27664291 DOI: 10.1016/J.Ophtha.2016.06.041  0.561
2016 Bennett J, Wellman J, Marshall KA, McCague S, Ashtari M, DiStefano-Pappas J, Elci OU, Chung DC, Sun J, Wright JF, Cross DR, Aravand P, Cyckowski LL, Bennicelli JL, Mingozzi F, et al. Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial. Lancet (London, England). PMID 27375040 DOI: 10.1016/S0140-6736(16)30371-3  0.652
2016 Duong TT, Vasireddy V, Mills JA, Bennett J. Retinas in a Dish Peek into Inherited Retinal Degeneration. Cell Stem Cell. 18: 688-9. PMID 27257755 DOI: 10.1016/J.Stem.2016.05.021  0.845
2016 Palfi A, Chadderton N, O'Reilly M, Nagel-Wolfrum K, Wolfrum U, Bennett J, Humphries P, Kenna P, Millington-Ward S, Farrar J. Corrigendum to "Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho-/- mouse". Molecular Therapy. Methods & Clinical Development. 3: 16032. PMID 27257610 DOI: 10.1038/Mtm.2016.32  0.424
2016 Garanto A, Chung DC, Duijkers L, Corral-Serrano JC, Messchaert M, Xiao R, Bennett J, Vandenberghe LH, Collin RW. In vitro and in vivo rescue of aberrant splicing in CEP290-associated LCA by antisense oligonucleotide delivery. Human Molecular Genetics. PMID 27106101 DOI: 10.1093/Hmg/Ddw118  0.759
2016 Mei X, Chaffiol A, Kole C, Yang Y, Millet-Puel G, Clérin E, Aït-Ali N, Bennett J, Dalkara D, Sahel JA, Duebel J, Leveillard T. The thioredoxin encoded by the Rod-derived Cone Viability Factor gene protects cone photoreceptors against oxidative stress. Antioxidants & Redox Signaling. PMID 27025156 DOI: 10.1089/ars.2015.6509  0.396
2016 Testa F, Maguire AM, Rossi S, Marshall K, Auricchio A, Melillo P, Bennett J, Simonelli F. Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes. Advances in Experimental Medicine and Biology. 854: 533-9. PMID 26427456 DOI: 10.1007/978-3-319-17121-0_71  0.442
2016 Leroy B, Maguire A, Russell S, Wellman J, Yu Z, Chung D, High K, Bennett J. Current gene therapy trials for inherited retinal disorders Acta Ophthalmologica. 94. DOI: 10.1111/J.1755-3768.2016.0160  0.52
2016 Duong TT, Vasireddy V, Merkel CE, Bennicelli JL, Bennett J. 556. Comparative In Vitro Transduction Efficiency of AAV Vector Serotypes 1-9 in Different Cellular Models Molecular Therapy. 24. DOI: 10.1016/S1525-0016(16)33364-0  0.834
2016 Vasireddy V, Duong TT, Bennicelli JL, Bennett J. 553. Comparision of AAV Serotypes for Gene Delivery to iPSC Derived RPE Molecular Therapy. 24. DOI: 10.1016/S1525-0016(16)33361-5  0.871
2016 Ramachandran PS, Nikonov S, Willett K, Huckfeldt R, Lyubarsky A, Morgan J, Aleman T, Maguire A, Bennett J. 270. Optogenetic Activation of Remnant Cone Cells Can Restore Ganglion Cell Light Responses in a Canine Model of Retinitis Pigmentosa Molecular Therapy. 24: S107. DOI: 10.1016/S1525-0016(16)33079-9  0.842
2016 Ashtari M, Cook P, Zhang H, Cyckowski L, Nikonova E, Young G, Marshall K, Gee J, Leopold D, Baker C, Maguire A, Bennett J. 265. Brain Pathways Enabling Vision in LCA Patients Before and After Gene Therapy Molecular Therapy. 24: S105. DOI: 10.1016/S1525-0016(16)33074-X  0.431
2016 Wielechowski E, Medina-Jaszek A, Ahonkhai O, Arif M, Bennett J, Maguire A, Tretiakova A, Wilson JM. 189. Therapeutic Gene Transfer as a Treatment Option for Age-Related Macular Degeneration Molecular Therapy. 24: S74. DOI: 10.1016/S1525-0016(16)32998-7  0.528
2016 Hui DJ, Chen Y, Antrilli T, Liu Y, Corbau R, Russell SR, Maguire AM, Bennett J, High KA. 185. Safety Study by Validated Immunoassays in a Phase III Study of Subjects with Inherited Retinal Dystrophy Due to Mutations in the Gene Encoding Human Retinal Pigment Epithelium-Specific Protein 65 (RPE65) Injected with Adeno-Associated Viral Vectors Molecular Therapy. 24: S72-S73. DOI: 10.1016/S1525-0016(16)32994-X  0.441
2016 Drack AV, Chung D, Russell S, Bennett J, Wellman J, Yu ZF, Maguire A, Stone EM, High K. Results of phase III clinical trial subretinal gene therapy for RPE65-mediated Leber congenital amaurosis (LCA) Journal of American Association For Pediatric Ophthalmology and Strabismus. 20: e4. DOI: 10.1016/J.Jaapos.2016.07.015  0.371
2015 Sochor MA, Vasireddy V, Drivas TG, Wojno A, Doung T, Shpylchak I, Bennicelli J, Chung D, Bennett J, Lewis M. An Autogenously Regulated Expression System for Gene Therapeutic Ocular Applications. Scientific Reports. 5: 17105. PMID 26597678 DOI: 10.1038/Srep17105  0.82
2015 Ashtari M, Zhang H, Cook PA, Cyckowski LL, Shindler KS, Marshall KA, Aravand P, Vossough A, Gee JC, Maguire AM, Baker CI, Bennett J. Plasticity of the human visual system after retinal gene therapy in patients with Leber's congenital amaurosis. Science Translational Medicine. 7: 296ra110. PMID 26180100 DOI: 10.1126/Scitranslmed.Aaa8791  0.458
2015 Vasireddy V, Mills JA, Gaddameedi R, Basner-Tschakarjan E, Kohnke M, Black AD, Alexandrov K, Zhou S, Maguire AM, Chung DC, Mac H, Sullivan L, Gadue P, Bennicelli JL, French DL, ... Bennett J, et al. Correction: AAV-Mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models. Plos One. 10: e0129982. PMID 26090960 DOI: 10.1371/Journal.Pone.0129982  0.807
2015 Drivas TG, Wojno AP, Tucker BA, Stone EM, Bennett J. Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis. Science Translational Medicine. 7: 291ra97. PMID 26062849 DOI: 10.1126/Scitranslmed.Aaa5370  0.805
2015 Palfi A, Chadderton N, O'Reilly M, Nagel-Wolfrum K, Wolfrum U, Bennett J, Humphries P, Kenna P, Millington-Ward S, Farrar J. Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho(-/-) mouse. Molecular Therapy. Methods & Clinical Development. 2: 15016. PMID 26029727 DOI: 10.1038/Mtm.2015.16  0.583
2015 Ramachandran PS, Song JY, Bennett J. Exploiting metabolic and antioxidant pathways to maintain vision in blinding disease. The Journal of Clinical Investigation. 125: 1390-2. PMID 25798615 DOI: 10.1172/Jci80821  0.845
2015 Pierce EA, Bennett J. The Status of RPE65 Gene Therapy Trials: Safety and Efficacy. Cold Spring Harbor Perspectives in Medicine. PMID 25635059 DOI: 10.1101/Cshperspect.A017285  0.552
2015 Elachouri G, Lee-Rivera I, Clérin E, Argentini M, Fridlich R, Blond F, Ferracane V, Yang Y, Raffelsberger W, Wan J, Bennett J, Sahel JA, Zack DJ, Léveillard T. Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage. Free Radical Biology & Medicine. 81: 22-9. PMID 25596499 DOI: 10.1016/J.Freeradbiomed.2015.01.003  0.449
2015 Ashtari M, Zhang H, Cook PA, Cyckowski LL, Shindler KS, Marshall KA, Aravand P, Vossough A, Gee JC, Maguire AM, Baker CI, Bennett J. Plasticity of the human visual system after retinal gene therapy in patients with Leber's congenital amaurosis Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aaa8791  0.388
2015 Hacia JG, Bennicelli J, Huang N, Braverman NE, Steinberg SJ, Bennett J. 499. Retinal Gene Therapy for Peroxisome Biogenesis Disorders Molecular Therapy. 23: S199. DOI: 10.1016/S1525-0016(16)34108-9  0.569
2014 Morgan JI, Han G, Klinman E, Maguire WM, Chung DC, Maguire AM, Bennett J. High-resolution adaptive optics retinal imaging of cellular structure in choroideremia. Investigative Ophthalmology & Visual Science. 55: 6381-97. PMID 25190651 DOI: 10.1167/Iovs.13-13454  0.694
2014 Bennett J. My career path for developing gene therapy for blinding diseases: the importance of mentors, collaborators, and opportunities. Human Gene Therapy. 25: 663-70. PMID 25136912 DOI: 10.1089/Hum.2014.2529  0.365
2014 Cronin T, Vandenberghe LH, Hantz P, Juttner J, Reimann A, Kacsó AE, Huckfeldt RM, Busskamp V, Kohler H, Lagali PS, Roska B, Bennett J. Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter. Embo Molecular Medicine. 6: 1175-90. PMID 25092770 DOI: 10.15252/Emmm.201404077  0.842
2014 Minella AL, Mowat FM, Willett KL, Sledge D, Bartoe JT, Bennett J, Petersen-Jones SM. Differential targeting of feline photoreceptors by recombinant adeno-associated viral vectors: implications for preclinical gene therapy trials. Gene Therapy. 21: 913-20. PMID 25056608 DOI: 10.1038/Gt.2014.65  0.835
2014 Black A, Vasireddy V, Chung DC, Maguire AM, Gaddameedi R, Tolmachova T, Seabra M, Bennett J. Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models. The Journal of Gene Medicine. 16: 122-30. PMID 24962736 DOI: 10.1002/Jgm.2768  0.855
2014 Drivas TG, Bennett J. CEP290 and the primary cilium. Advances in Experimental Medicine and Biology. 801: 519-25. PMID 24664739 DOI: 10.1007/978-1-4614-3209-8_66  0.742
2014 Hiebler S, Masuda T, Hacia JG, Moser AB, Faust PL, Liu A, Chowdhury N, Huang N, Lauer A, Bennett J, Watkins PA, Zack DJ, Braverman NE, Raymond GV, Steinberg SJ. The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder. Molecular Genetics and Metabolism. 111: 522-32. PMID 24503136 DOI: 10.1016/J.Ymgme.2014.01.008  0.408
2014 Huckfeldt RM, Bennett J. Promising first steps in gene therapy for choroideremia. Human Gene Therapy. 25: 96-7. PMID 24502407 DOI: 10.1089/hum.2014.2503  0.711
2014 Ashtari M, Cyckowski L, Yazdi A, Viands A, Marshall K, Bókkon I, Maguire A, Bennett J. fMRI of retina-originated phosphenes experienced by patients with Leber congenital amaurosis. Plos One. 9: e86068. PMID 24465873 DOI: 10.1371/Journal.Pone.0086068  0.426
2014 Canver MC, Canver AC, Revere KE, Amado D, Bennett J, Chung DC. Novel mathematical algorithm for pupillometric data analysis. Computer Methods and Programs in Biomedicine. 113: 221-5. PMID 24129048 DOI: 10.1016/J.Cmpb.2013.08.008  0.802
2014 Wojno A, Drivas T, Tucker B, Stone E, Bennett J. Basel exon skipping - a novel model of disease pathogenesis to explain CEP290-associated retinal degeneration and related ciliopathies Journal of Vision. 14: 85-85. DOI: 10.1167/14.15.85  0.831
2014 Nikonov S, Huckfeldt R, Willett K, Bennett J. Expression of halorhodopsin in bipolar cells can restore ganglion cell light responses in a large animal (canine) model of cone-rod dystrophy. Journal of Vision. 14: 37-37. DOI: 10.1167/14.15.37  0.815
2014 Mackay DS, Borman AD, Sui R, van den Born LI, Berson EL, Ocaka LA, Davidson AE, Heckenlively JR, Branham K, Ren H, Lopez I, Maria M, Azam M, Henkes A, Blokland E, ... ... Bennett J, et al. Screening of a Large Cohort of Leber Congenital Amaurosis and Retinitis Pigmentosa Patients Identifies Novel LCA5 Mutations and New Genotype-Phenotype Correlations. [34, 11, 1537-1546, 10.1002/humu.22398] Human Mutation. 35: 150-150. DOI: 10.1002/Humu.22467  0.378
2013 Drivas TG, Holzbaur EL, Bennett J. Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration. The Journal of Clinical Investigation. 123: 4525-39. PMID 24051377 DOI: 10.1172/Jci69448  0.736
2013 Willett K, Bennett J. Immunology of AAV-Mediated Gene Transfer in the Eye. Frontiers in Immunology. 4: 261. PMID 24009613 DOI: 10.3389/Fimmu.2013.00261  0.782
2013 Bennicelli JL, Bennett J. Stem cells set their sights on retinitis pigmentosa. Elife. 2: e01291. PMID 23991287 DOI: 10.7554/Elife.01291  0.431
2013 Mackay DS, Borman AD, Sui R, van den Born LI, Berson EL, Ocaka LA, Davidson AE, Heckenlively JR, Branham K, Ren H, Lopez I, Maria M, Azam M, Henkes A, Blokland E, ... ... Bennett J, et al. Screening of a large cohort of leber congenital amaurosis and retinitis pigmentosa patients identifies novel LCA5 mutations and new genotype-phenotype correlations. Human Mutation. 34: 1537-46. PMID 23946133 DOI: 10.1002/Humu.22398  0.404
2013 Vasireddy V, Mills JA, Gaddameedi R, Basner-Tschakarjan E, Kohnke M, Black AD, Alexandrov K, Zhou S, Maguire AM, Chung DC, Mac H, Sullivan L, Gadue P, Bennicelli JL, French DL, ... Bennett J, et al. AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models. Plos One. 8: e61396. PMID 23667438 DOI: 10.1371/Journal.Pone.0061396  0.853
2013 Simonato M, Bennett J, Boulis NM, Castro MG, Fink DJ, Goins WF, Gray SJ, Lowenstein PR, Vandenberghe LH, Wilson TJ, Wolfe JH, Glorioso JC. Progress in gene therapy for neurological disorders. Nature Reviews. Neurology. 9: 277-91. PMID 23609618 DOI: 10.1038/Nrneurol.2013.56  0.667
2013 Testa F, Maguire AM, Rossi S, Pierce EA, Melillo P, Marshall K, Banfi S, Surace EM, Sun J, Acerra C, Wright JF, Wellman J, High KA, Auricchio A, Bennett J, et al. Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital Amaurosis type 2. Ophthalmology. 120: 1283-91. PMID 23474247 DOI: 10.1016/J.Ophtha.2012.11.048  0.703
2013 Wojno AP, Pierce EA, Bennett J. Seeing the light. Science Translational Medicine. 5: 175fs8. PMID 23467559 DOI: 10.1126/Scitranslmed.3005798  0.832
2013 Vandenberghe LH, Bell P, Maguire AM, Xiao R, Hopkins TB, Grant R, Bennett J, Wilson JM. AAV9 targets cone photoreceptors in the nonhuman primate retina. Plos One. 8: e53463. PMID 23382846 DOI: 10.1371/Journal.Pone.0053463  0.767
2013 Vandenberghe LH, Bell P, Maguire AM, Xiao R, Hopkins TB, Grant R, Bennett J, Wilson JM. Correction: AAV9 Targets Cone Photoreceptors in the Nonhuman Primate Retina Plos One. 8. DOI: 10.1371/Annotation/64B90996-4634-4C63-B737-634397B0B445  0.692
2013 Simonato M, Bennett J, Boulis NM, Castro MG, Fink D, Goins WF, Gray SJ, Lowenstein PR, Vandenberghe L, Wilson TJ, Wolfe JH, Glorioso JC. Correction: Progress in gene therapy for neurological disorders Nature Reviews Neurology. 9: 298-298. DOI: 10.1038/Nrneurol.2013.103  0.585
2012 Cronin T, Chung DC, Yang Y, Nandrot EF, Bennett J. The Signalling Role of the avβ5-Integrin Can Impact the Efficacy of AAV in Retinal Gene Therapy. Pharmaceuticals (Basel, Switzerland). 5: 447-59. PMID 24281556 DOI: 10.3390/Ph5050447  0.86
2012 Collin RW, den Hollander AI, van der Velde-Visser SD, Bennicelli J, Bennett J, Cremers FP. Antisense Oligonucleotide (AON)-based Therapy for Leber Congenital Amaurosis Caused by a Frequent Mutation in CEP290. Molecular Therapy. Nucleic Acids. 1: e14. PMID 23343883 DOI: 10.1038/Mtna.2012.3  0.387
2012 Branham K, Othman M, Brumm M, Karoukis AJ, Atmaca-Sonmez P, Yashar BM, Schwartz SB, Stover NB, Trzupek K, Wheaton D, Jennings B, Ciccarelli ML, Jayasundera KT, Lewis RA, Birch D, ... Bennett J, et al. Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease. Investigative Ophthalmology & Visual Science. 53: 8232-7. PMID 23150612 DOI: 10.1167/Iovs.12-11025  0.426
2012 Drivas TG, Bennett J. The bionic retina: a small molecule with big potential for visual restoration. Neuron. 75: 185-7. PMID 22841303 DOI: 10.1016/J.Neuron.2012.06.010  0.768
2012 Melillo P, Pecchia L, Testa F, Rossi S, Bennett J, Simonelli F. Pupillometric analysis for assessment of gene therapy in Leber Congenital Amaurosis patients Biomedical Engineering Online. 11. PMID 22812667 DOI: 10.1186/1475-925X-11-40  0.429
2012 Bennett J, Chung DC, Maguire A. Gene delivery to the retina: from mouse to man. Methods in Enzymology. 507: 255-74. PMID 22365778 DOI: 10.1016/B978-0-12-386509-0.00013-2  0.701
2012 Jaillard C, Mouret A, Niepon ML, Clérin E, Yang Y, Lee-Rivera I, Aït-Ali N, Millet-Puel G, Cronin T, Sedmak T, Raffelsberger W, Kinzel B, Trembleau A, Poch O, Bennett J, et al. Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity. Human Molecular Genetics. 21: 2298-311. PMID 22343139 DOI: 10.1093/Hmg/Dds050  0.82
2012 Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, et al. AAV2 gene therapy readministration in three adults with congenital blindness. Science Translational Medicine. 4: 120ra15. PMID 22323828 DOI: 10.1126/scitranslmed.3002865  0.641
2012 Cronin T, Lyubarsky A, Bennett J. Dark-rearing the rd10 mouse: implications for therapy. Advances in Experimental Medicine and Biology. 723: 129-36. PMID 22183325 DOI: 10.1007/978-1-4614-0631-0_18  0.84
2012 Bennett J, Maguire AM. Gene Therapy for Retinal Disease Retina Fifth Edition. 1: 652-668. DOI: 10.1016/B978-1-4557-0737-9.00034-5  0.43
2011 Chung DC, Fogelgren B, Park KM, Heidenberg J, Zuo X, Huang L, Bennett J, Lipschutz JH. Adeno-Associated Virus-Mediated Gene Transfer to Renal Tubule Cells via a Retrograde Ureteral Approach. Nephron Extra. 1: 217-23. PMID 22470395 DOI: 10.1159/000333071  0.609
2011 Stieger K, Cronin T, Bennett J, Rolling F. Adeno-associated virus mediated gene therapy for retinal degenerative diseases. Methods in Molecular Biology (Clifton, N.J.). 807: 179-218. PMID 22034031 DOI: 10.1007/978-1-61779-370-7_8  0.865
2011 Cronin T, Bennett J. Switching on the lights: the use of optogenetics to advance retinal gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1190-2. PMID 21720380 DOI: 10.1038/Mt.2011.115  0.84
2011 Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, Wang L, Castle MJ, Maguire AC, Grant R, Wolfe JH, Wilson JM, Bennett J. Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Science Translational Medicine. 3: 88ra54. PMID 21697530 DOI: 10.1126/Scitranslmed.3002103  0.785
2011 Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler KS, Bennett J. The human visual cortex responds to gene therapy-mediated recovery of retinal function. The Journal of Clinical Investigation. 121: 2160-8. PMID 21606598 DOI: 10.1172/Jci57377  0.662
2011 Boldt K, Mans DA, Won J, van Reeuwijk J, Vogt A, Kinkl N, Letteboer SJ, Hicks WL, Hurd RE, Naggert JK, Texier Y, den Hollander AI, Koenekoop RK, Bennett J, Cremers FP, et al. Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice. The Journal of Clinical Investigation. 121: 2169-80. PMID 21606596 DOI: 10.1172/Jci45627  0.397
2011 Millington-Ward S, Chadderton N, O'Reilly M, Palfi A, Goldmann T, Kilty C, Humphries M, Wolfrum U, Bennett J, Humphries P, Kenna PF, Farrar GJ. Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 642-9. PMID 21224835 DOI: 10.1038/Mt.2010.293  0.54
2011 Fradot M, Busskamp V, Forster V, Cronin T, Léveillard T, Bennett J, Sahel JA, Roska B, Picaud S. Gene therapy in ophthalmology: validation on cultured retinal cells and explants from postmortem human eyes. Human Gene Therapy. 22: 587-93. PMID 21142470 DOI: 10.1089/Hum.2010.157  0.851
2011 Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler KS, Bennett J. The human visual cortex responds to gene therapy-mediated recovery of retinal function (The Journal of Clinical Investigation (2011) 121, 6, (2160-2168) DOI: 10.1172/JCI57377) Journal of Clinical Investigation. 121: 2945. DOI: 10.1172/JCI59208  0.365
2011 Bennett J, Maguire AM. The evolution of retinal gene therapy: From DNA to FDA Retina Today. 55-58.  0.356
2011 Den Hollander AI, Black A, Bennett J, Cremers FPM. Lighting a candle in the dark: Advances in genetics and gene therapy of recessive retinal dystrophies (Journal of Clinical Investigation (2010) 120, 9 (3042-3053) DOI: 10.1172/JCI42258) Journal of Clinical Investigation. 121: 456.  0.382
2010 den Hollander AI, Black A, Bennett J, Cremers FP. Lighting a candle in the dark: advances in genetics and gene therapy of recessive retinal dystrophies. The Journal of Clinical Investigation. 120: 3042-53. PMID 20811160 DOI: 10.1172/Jci42258  0.855
2010 Amado D, Mingozzi F, Hui D, Bennicelli JL, Wei Z, Chen Y, Bote E, Grant RL, Golden JA, Narfstrom K, Syed NA, Orlin SE, High KA, Maguire AM, Bennett J. Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness. Science Translational Medicine. 2: 21ra16. PMID 20374996 DOI: 10.1126/Scitranslmed.3000659  0.828
2010 Simonelli F, Maguire AM, Testa F, Pierce EA, Mingozzi F, Bennicelli JL, Rossi S, Marshall K, Banfi S, Surace EM, Sun J, Redmond TM, Zhu X, Shindler KS, Ying GS, ... ... Bennett J, et al. Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 643-50. PMID 19953081 DOI: 10.1038/Mt.2009.277  0.778
2010 Canver MC, Canver AC, Revere KE, Amado D, Bennett J, Chung DC. Algorithm for pupillometric data analysis Proceedings of the 2010 Ieee 36th Annual Northeast Bioengineering Conference, Nebec 2010. DOI: 10.1109/NEBC.2010.5458283  0.746
2009 Bennett J. Gene therapy for color blindness. The New England Journal of Medicine. 361: 2483-4. PMID 20018970 DOI: 10.1056/Nejmcibr0908643  0.434
2009 Maguire AM, High KA, Auricchio A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli JL, Ying GS, Rossi S, Fulton A, Marshall KA, Banfi S, Chung DC, Morgan JI, ... ... Bennett J, et al. Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial. Lancet. 374: 1597-605. PMID 19854499 DOI: 10.1016/S0140-6736(09)61836-5  0.84
2009 Jacobs JB, Dell'Osso LF, Wang ZI, Acland GM, Bennett J. Using the NAFX to measure the effectiveness over time of gene therapy in canine LCA. Investigative Ophthalmology & Visual Science. 50: 4685-92. PMID 19458334 DOI: 10.1167/Iovs.09-3387  0.368
2009 Zhang Y, Singh MK, Degenhardt KR, Lu MM, Bennett J, Yoshida Y, Epstein JA. Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Developmental Biology. 325: 82-93. PMID 18992737 DOI: 10.1016/J.Ydbio.2008.09.031  0.358
2008 Maguire AM, Simonelli F, Pierce EA, Pugh EN, Mingozzi F, Bennicelli J, Banfi S, Marshall KA, Testa F, Surace EM, Rossi S, Lyubarsky A, Arruda VR, Konkle B, Stone E, ... ... Bennett J, et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. The New England Journal of Medicine. 358: 2240-8. PMID 18441370 DOI: 10.1056/Nejmoa0802315  0.764
2008 Allocca M, Doria M, Petrillo M, Colella P, Garcia-Hoyos M, Gibbs D, Kim SR, Maguire A, Rex TS, Di Vicino U, Cutillo L, Sparrow JR, Williams DS, Bennett J, Auricchio A. Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. The Journal of Clinical Investigation. 118: 1955-64. PMID 18414684 DOI: 10.1172/Jci34316  0.766
2008 Lebherz C, Maguire A, Tang W, Bennett J, Wilson JM. Novel AAV serotypes for improved ocular gene transfer. The Journal of Gene Medicine. 10: 375-82. PMID 18278824 DOI: 10.1002/Jgm.1126  0.6
2008 Bennicelli J, Wright JF, Komaromy A, Jacobs JB, Hauck B, Zelenaia O, Mingozzi F, Hui D, Chung D, Rex TS, Wei Z, Qu G, Zhou S, Zeiss C, Arruda VR, ... ... Bennett J, et al. Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 458-65. PMID 18209734 DOI: 10.1038/Sj.Mt.6300389  0.803
2008 Liu X, Rasmussen CA, Bennett J, Brandt CR, Gabelt BT, Kaufman PL. Progress and Prospects in Ocular Gene Therapy Ocular Therapeutics. 393-420. DOI: 10.1016/B978-012370585-3.50020-0  0.309
2007 Bennett J. Retinal progenitor cells--timing is everything. The New England Journal of Medicine. 356: 1577-9. PMID 17429090 DOI: 10.1056/Nejmcibr070209  0.399
2007 Zhang Z, Tang W, Zhou R, Shen X, Wei Z, Patel AM, Povlishock JT, Bennett J, Strauss JF. Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins. Cell Motility and the Cytoskeleton. 64: 360-76. PMID 17323374 DOI: 10.1002/Cm.20189  0.306
2007 Endo M, Zoltick PW, Chung DC, Bennett J, Radu A, Muvarak N, Flake AW. Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 579-87. PMID 17245352 DOI: 10.1038/sj.mt.6300092  0.603
2006 Shindler KS, Guan Y, Ventura E, Bennett J, Rostami A. Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 12: 526-32. PMID 17086896 DOI: 10.1177/1352458506070629  0.336
2006 Wilson DF, Vinogradov SA, Grosul P, Sund N, Vacarezza MN, Bennett J. Imaging oxygen pressure in the rodent retina by phosphorescence lifetime. Advances in Experimental Medicine and Biology. 578: 119-24. PMID 16927680 DOI: 10.1007/0-387-29540-2_19  0.416
2006 Jacobs JB, Dell'Osso LF, Hertle RW, Acland GM, Bennett J. Eye movement recordings as an effectiveness indicator of gene therapy in RPE65-deficient canines: implications for the ocular motor system. Investigative Ophthalmology & Visual Science. 47: 2865-75. PMID 16799026 DOI: 10.1167/Iovs.05-1233  0.449
2006 Bedrosian JC, Gratton MA, Brigande JV, Tang W, Landau J, Bennett J. In vivo delivery of recombinant viruses to the fetal murine cochlea: transduction characteristics and long-term effects on auditory function. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 328-35. PMID 16765094 DOI: 10.1016/J.Ymthe.2006.04.003  0.814
2006 Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Schwartz SB, Cideciyan AV, Zeiss CJ, Komaromy AM, Kaushal S, Roman AJ, Windsor EA, Sumaroka A, Pearce-Kelling SE, Conlon TJ, Chiodo VA, ... ... Bennett J, et al. Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 1074-84. PMID 16644289 DOI: 10.1016/J.Ymthe.2006.03.005  0.463
2006 Bennett J. Commentary: an aye for eye gene therapy. Human Gene Therapy. 17: 177-9. PMID 16454651 DOI: 10.1089/Hum.2006.17.177  0.417
2006 Zhang Z, Kostetskii I, Tang W, Haig-Ladewig L, Sapiro R, Wei Z, Patel AM, Bennett J, Gerton GL, Moss SB, Radice GL, Strauss JF. Deficiency of SPAG16L causes male infertility associated with impaired sperm motility. Biology of Reproduction. 74: 751-9. PMID 16382026 DOI: 10.1095/Biolreprod.105.049254  0.341
2006 Keiser NW, Maminishkis A, Bennicelli JL, Miller SS, Bennett J. 886. AAV-Mediated Somatic Gene Transfer as an Approach To Delineate Pathogenic Mechanisms in an Autosomal Dominant Blindness Disorder Resembling Age-Related Macular Degeneration (AMD) Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.975  0.798
2006 Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Boye SL, Schwartz SB, Cideciyan AV, Zeiss CJ, Komaromy AM, Roman AJ, Windsor EA, Sumaroka A, Pearce-Kelling SE, Conlon TJ, Li Q, ... ... Bennett J, et al. 881. Safety, Efficacy and Biodistribution of Recombinant AAV2-RPE65 Vector Delivered by Ocular Subretinal Injection Molecular Therapy. 13: S339. DOI: 10.1016/J.Ymthe.2006.08.970  0.429
2006 Bois GCD, Radoeva PD, Bennett J. 496. AAV-Mediated, Somatic Gene Transfer to RPE Cells in Order To Study the Pathogenesis of Macular Degeneration: Proteomic and Genomic Analysis Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.566  0.496
2006 Bedrosian JC, Anne Gratton M, Brigande JV, Tang W, Bennett J. 488. Adeno-Associated Viral Serotype 2/1 Is a Highly Efficient Vector for In Utero Gene Transfer to Hair Cell Precursors Molecular Therapy. 13: S189. DOI: 10.1016/J.Ymthe.2006.08.558  0.44
2006 Endo M, Zoltick PW, Chung DC, Bennett J, Flake AW. 92. Gene Transfer to Ocular Stem Cells by Early Gestational Intra-Amniotic Injection of Lentiviral Vector Molecular Therapy. 13: 579-587. DOI: 10.1016/J.Ymthe.2006.08.111  0.463
2005 Wilson DF, Vinogradov SA, Grosul P, Kuroki A, Bennett J. Imaging oxygen pressure in the retina of the mouse eye. Advances in Experimental Medicine and Biology. 566: 159-65. PMID 16594148 DOI: 10.1007/0-387-26206-7_22  0.794
2005 Rex TS, Peet JA, Surace EM, Calvert PD, Nikonov SS, Lyubarsky AL, Bendo E, Hughes T, Pugh EN, Bennett J. The distribution, concentration, and toxicity of enhanced green fluorescent protein in retinal cells after genomic or somatic (virus-mediated) gene transfer. Molecular Vision. 11: 1236-45. PMID 16402024  0.794
2005 Bennett J. Strategies for delivery of rod-derived cone viability factor. Retina (Philadelphia, Pa.). 25: S47. PMID 16374333 DOI: 10.1097/00006982-200512001-00020  0.332
2005 Keiser NW, Tang W, Wei Z, Bennett J. Spatial and temporal expression patterns of the choroideremia gene in the mouse retina. Molecular Vision. 11: 1052-60. PMID 16357828  0.816
2005 Cideciyan AV, Swider M, Aleman TS, Sumaroka A, Schwartz SB, Roman MI, Milam AH, Bennett J, Stone EM, Jacobson SG. ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina. Investigative Ophthalmology & Visual Science. 46: 4739-46. PMID 16303974 DOI: 10.1167/Iovs.05-0805  0.503
2005 Wang F, Tang W, McGraw HM, Bennett J, Enquist LW, Friedman HM. Herpes simplex virus type 1 glycoprotein e is required for axonal localization of capsid, tegument, and membrane glycoproteins. Journal of Virology. 79: 13362-72. PMID 16227258 DOI: 10.1128/Jvi.79.21.13362-13372.2005  0.321
2005 Acland GM, Aguirre GD, Bennett J, Aleman TS, Cideciyan AV, Bennicelli J, Dejneka NS, Pearce-Kelling SE, Maguire AM, Palczewski K, Hauswirth WW, Jacobson SG. Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 1072-82. PMID 16226919 DOI: 10.1016/J.Ymthe.2005.08.008  0.845
2005 Wilson DF, Vinogradov SA, Grosul P, Vaccarezza MN, Kuroki A, Bennett J. Oxygen distribution and vascular injury in the mouse eye measured by phosphorescence-lifetime imaging. Applied Optics. 44: 5239-48. PMID 16149347 DOI: 10.1364/Ao.44.005239  0.791
2005 Hahn P, Lindsten T, Tolentino M, Thompson CB, Bennett J, Dunaief JL. Persistent fetal ocular vasculature in mice deficient in bax and bak. Archives of Ophthalmology (Chicago, Ill. : 1960). 123: 797-802. PMID 15955981 DOI: 10.1001/Archopht.123.6.797  0.368
2005 Jacobson SG, Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Windsor EA, Traboulsi EI, Heon E, Pittler SJ, Milam AH, Maguire AM, Palczewski K, Stone EM, Bennett J. Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proceedings of the National Academy of Sciences of the United States of America. 102: 6177-82. PMID 15837919 DOI: 10.1073/Pnas.0500646102  0.581
2005 Zhang Z, Jones BH, Tang W, Moss SB, Wei Z, Ho C, Pollack M, Horowitz E, Bennett J, Baker ME, Strauss JF. Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16. Molecular & Cellular Proteomics : McP. 4: 914-23. PMID 15827353 DOI: 10.1074/Mcp.M400177-Mcp200  0.316
2005 Lebherz C, Maguire AM, Auricchio A, Tang W, Aleman TS, Wei Z, Grant R, Cideciyan AV, Jacobson SG, Wilson JM, Bennett J. Nonhuman primate models for diabetic ocular neovascularization using AAV2-mediated overexpression of vascular endothelial growth factor. Diabetes. 54: 1141-9. PMID 15793254 DOI: 10.2337/Diabetes.54.4.1141  0.49
2005 Lebherz C, Auricchio A, Maguire AM, Rivera VM, Tang W, Grant RL, Clackson T, Bennett J, Wilson JM. Long-term inducible gene expression in the eye via adeno-associated virus gene transfer in nonhuman primates. Human Gene Therapy. 16: 178-86. PMID 15761258 DOI: 10.1089/Hum.2005.16.178  0.6
2005 Schwartz SB, Aleman TS, Cideciyan AV, Windsor EA, Sumaroka A, Roman AJ, Rane T, Smilko EE, Bennett J, Stone EM, Kimberling WJ, Liu XZ, Jacobson SG. Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype. Investigative Ophthalmology & Visual Science. 46: 734-43. PMID 15671307 DOI: 10.1167/Iovs.04-1136  0.519
2005 Keiser NW, Chung DC, Tang W, Wei Z, Maguire A, Bennett J, Bennicelli JL. 135. AAV-Mediated Gene Delivery To Evaluate the Biology of an Inherited Macular Degeneration Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.140  0.833
2004 Schuettauf F, Vorwerk C, Naskar R, Orlin A, Quinto K, Zurakowski D, Dejneka NS, Klein RL, Meyer EM, Bennett J. Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity. Current Eye Research. 29: 379-86. PMID 15764082 DOI: 10.1080/02713680490517872  0.801
2004 Dejneka NS, Kuroki AM, Fosnot J, Tang W, Tolentino MJ, Bennett J. Systemic rapamycin inhibits retinal and choroidal neovascularization in mice. Molecular Vision. 10: 964-72. PMID 15623986  0.809
2004 Rex TS, Tsui I, Hahn P, Maguire AM, Duan D, Bennett J, Dunaief JL. Adenovirus-mediated delivery of catalase to retinal pigment epithelial cells protects neighboring photoreceptors from photo-oxidative stress. Human Gene Therapy. 15: 960-7. PMID 15585111 DOI: 10.1089/Hum.2004.15.960  0.713
2004 Wong WT, Rex TS, Auricchio A, Maguire AM, Chung D, Tang W, Bennett J. Effect of over-expression of pigment epithelium derived factor (PEDF) on developing retinal vasculature in the mouse. Molecular Vision. 10: 837-44. PMID 15547489  0.791
2004 Rex TS, Allocca M, Domenici L, Surace EM, Maguire AM, Lyubarsky A, Cellerino A, Bennett J, Auricchio A. Systemic but not intraocular Epo gene transfer protects the retina from light-and genetic-induced degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 855-61. PMID 15509503 DOI: 10.1016/J.Ymthe.2004.07.027  0.846
2004 Chen L, Wu W, Dentchev T, Zeng Y, Wang J, Tsui I, Tobias JW, Bennett J, Baldwin D, Dunaief JL. Light damage induced changes in mouse retinal gene expression. Experimental Eye Research. 79: 239-47. PMID 15325571 DOI: 10.1016/J.Exer.2004.05.002  0.442
2004 Aleman TS, Jacobson SG, Chico JD, Scott ML, Cheung AY, Windsor EA, Furushima M, Redmond TM, Bennett J, Palczewski K, Cideciyan AV. Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Investigative Ophthalmology & Visual Science. 45: 1259-71. PMID 15037595 DOI: 10.1167/Iovs.03-1230  0.41
2004 Dejneka NS, Surace EM, Aleman TS, Cideciyan AV, Lyubarsky A, Savchenko A, Redmond TM, Tang W, Wei Z, Rex TS, Glover E, Maguire AM, Pugh EN, Jacobson SG, Bennett J. In utero gene therapy rescues vision in a murine model of congenital blindness. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 182-8. PMID 14759802 DOI: 10.1016/J.Ymthe.2003.11.013  0.867
2004 Bennett J. Gene therapy for Leber congenital amaurosis. Novartis Foundation Symposium. 255: 195-202; discussion . PMID 14750605  0.462
2004 Cideciyan AV, Aleman TS, Swider M, Schwartz SB, Steinberg JD, Brucker AJ, Maguire AM, Bennett J, Stone EM, Jacobson SG. Mutations in ABCA4 result in accumulation of lipofuscin before slowing of the retinoid cycle: a reappraisal of the human disease sequence. Human Molecular Genetics. 13: 525-34. PMID 14709597 DOI: 10.1093/Hmg/Ddh048  0.471
2004 Lebherz C, Maguire AM, Auricchio A, Tang W, Aleman TS, Wei Z, Grant RL, Cideciyan AV, Jacobson SG, Wilson JM, Bennett J. 218. Nonhuman Primate Models for Retinal and Choroidal Neovascularization Using AAV2-Mediated Overexpression of Vascular Endothelial Growth Factor Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.160  0.533
2003 Liang FQ, Surace E, Dejneka NS, Maguire AM, Bennett J. Müller cell transduction by AAV2 in normal and degenerative retinas. Advances in Experimental Medicine and Biology. 533: 439-45. PMID 15180296 DOI: 10.1007/978-1-4615-0067-4_56  0.818
2003 Dejneka NS, Surace EM, Bennett J. Gene therapy for Leber congenital amaurosis. Advances in Experimental Medicine and Biology. 533: 415-22. PMID 15180293 DOI: 10.1007/978-1-4615-0067-4_53  0.807
2003 Hahn P, Lindsten T, Ying GS, Bennett J, Milam AH, Thompson CB, Dunaief JL. Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis. Investigative Ophthalmology & Visual Science. 44: 3598-605. PMID 12882813 DOI: 10.1167/Iovs.02-1113  0.452
2003 Dejneka NS, Rex TS, Bennett J. Gene therapy and animal models for retinal disease. Developments in Ophthalmology. 37: 188-98. PMID 12876838 DOI: 10.1159/000072047  0.855
2003 Surace EM, Auricchio A, Reich SJ, Rex T, Glover E, Pineles S, Tang W, O'Connor E, Lyubarsky A, Savchenko A, Pugh EN, Maguire AM, Wilson JM, Bennett J. Delivery of adeno-associated virus vectors to the fetal retina: impact of viral capsid proteins on retinal neuronal progenitor transduction. Journal of Virology. 77: 7957-63. PMID 12829835 DOI: 10.1128/Jvi.77.14.7957-7963.2003  0.853
2003 Reich SJ, Fosnot J, Kuroki A, Tang W, Yang X, Maguire AM, Bennett J, Tolentino MJ. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Molecular Vision. 9: 210-6. PMID 12789138  0.821
2003 Reich SJ, Bennett J. Gene therapy for ocular neovascularization: a cure in sight. Current Opinion in Genetics & Development. 13: 317-22. PMID 12787796 DOI: 10.1016/S0959-437X(03)00043-1  0.487
2003 Bennett J. Immune response following intraocular delivery of recombinant viral vectors Gene Therapy. 10: 977-982. PMID 12756418 DOI: 10.1038/Sj.Gt.3302030  0.437
2003 Chen L, Dentchev T, Wong R, Hahn P, Wen R, Bennett J, Dunaief JL. Increased expression of ceruloplasmin in the retina following photic injury. Molecular Vision. 9: 151-8. PMID 12724641  0.359
2003 Anand V, Barral DC, Zeng Y, Brunsmann F, Maguire AM, Seabra MC, Bennett J. Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus. Vision Research. 43: 919-26. PMID 12668061 DOI: 10.1016/S0042-6989(02)00389-9  0.492
2003 Reich SJ, Auricchio A, Hildinger M, Glover E, Maguire AM, Wilson JM, Bennett J. Efficient trans-splicing in the retina expands the utility of adeno-associated virus as a vector for gene therapy. Human Gene Therapy. 14: 37-44. PMID 12573057 DOI: 10.1089/10430340360464697  0.583
2003 Hansen KA, Sugino IK, Yagi F, Wang H, Tsukahara I, Gullapalli V, Bennett J, Zarbin MA. Adeno-associated virus encoding green fluorescent protein as a label for retinal pigment epithelium. Investigative Ophthalmology & Visual Science. 44: 772-80. PMID 12556413 DOI: 10.1167/Iovs.02-0091  0.42
2002 Behling KC, Surace EM, Bennett J. Pigment epithelium-derived factor expression in the developing mouse eye. Molecular Vision. 8: 449-54. PMID 12447163  0.825
2002 Ho TT, Maguire AM, Aguirre GD, Surace EM, Anand V, Zeng Y, Salvetti A, Hopwood JJ, Haskins ME, Bennett J. Phenotypic rescue after adeno-associated virus-mediated delivery of 4-sulfatase to the retinal pigment epithelium of feline mucopolysaccharidosis VI. The Journal of Gene Medicine. 4: 613-21. PMID 12439853 DOI: 10.1002/Jgm.302  0.767
2002 Auricchio A, Behling KC, Maguire AM, O'Connor EM, Bennett J, Wilson JM, Tolentino MJ. Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 490-4. PMID 12377190 DOI: 10.1006/Mthe.2002.0702  0.824
2002 Auricchio A, Rivera VM, Clackson T, O'Connor EE, Maguire AM, Tolentino MJ, Bennett J, Wilson JM. Pharmacological regulation of protein expression from adeno-associated viral vectors in the eye. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 238-42. PMID 12161190 DOI: 10.1006/Mthe.2002.0660  0.582
2002 Duncan JL, Aleman TS, Gardner LM, De Castro E, Marks DA, Emmons JM, Bieber ML, Steinberg JD, Bennett J, Stone EM, MacDonald IM, Cideciyan AV, Maguire MG, Jacobson SG. Macular pigment and lutein supplementation in choroideremia. Experimental Eye Research. 74: 371-81. PMID 12014918 DOI: 10.1006/Exer.2001.1126  0.47
2002 Jacobson SG, Cideciyan AV, Bennett J, Kingsley RM, Sheffield VC, Stone EM. Novel mutation in the TIMP3 gene causes Sorsby fundus dystrophy. Archives of Ophthalmology (Chicago, Ill. : 1960). 120: 376-9. PMID 11879143 DOI: 10.1001/Archopht.120.3.376  0.485
2002 Anand V, Duffy B, Yang Z, Dejneka NS, Maguire AM, Bennett J. A deviant immune response to viral proteins and transgene product is generated on subretinal administration of adenovirus and adeno-associated virus. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 125-32. PMID 11829519 DOI: 10.1006/Mthe.2002.0525  0.776
2001 Gupta AR, Dejneka NS, Maguire AM, Bennett J. Generation of transgenic mice for studies of ocular development and disease. Methods in Molecular Medicine. 47: 191-214. PMID 21394586 DOI: 10.1385/1-59259-085-3:191  0.812
2001 Liang F, Anand V, Maguire AM, Bennett J. Intraocular delivery of recombinant virus. Methods in Molecular Medicine. 47: 125-139. PMID 21394582 DOI: 10.1385/1-59259-085-3:125  0.525
2001 Auricchio A, Kobinger G, Anand V, Hildinger M, O'Connor E, Maguire AM, Wilson JM, Bennett J. Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model. Human Molecular Genetics. 10: 3075-81. PMID 11751689 DOI: 10.1093/Hmg/10.26.3075  0.596
2001 Liang FQ, Aleman TS, Dejneka NS, Dudus L, Fisher KJ, Maguire AM, Jacobson SG, Bennett J. Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 461-72. PMID 11708883 DOI: 10.1006/Mthe.2001.0473  0.823
2001 Dejneka NS, Bennett J. Gene therapy and retinitis pigmentosa: advances and future challenges Bioessays. 23: 662-668. PMID 11462220 DOI: 10.1002/Bies.1092  0.842
2001 Karakousis PC, John SK, Behling KC, Surace EM, Smith JE, Hendrickson A, Tang WX, Bennett J, Milam AH. Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues. Molecular Vision. 7: 154-63. PMID 11438800  0.819
2001 Gupta AR, Dejneka NS, D'Amato RJ, Yang Z, Syed N, Maguire AM, Bennett J. Strain-dependent anterior segment neovascularization following intravitreal gene transfer of basic fibroblast growth factor (bFGF). The Journal of Gene Medicine. 3: 252-9. PMID 11437330 DOI: 10.1002/1521-2254(200105/06)3:3<252::Aid-Jgm185>3.0.Co;2-S  0.814
2001 Acland GM, Aguirre GD, Ray J, Zhang Q, Aleman TS, Cideciyan AV, Pearce-Kelling SE, Anand V, Zeng Y, Maguire AM, Jacobson SG, Hauswirth WW, Bennett J. Gene therapy restores vision in a canine model of childhood blindness. Nature Genetics. 28: 92-5. PMID 11326284 DOI: 10.1038/Ng0501-92  0.577
2001 Liang F, Aleman TS, Zaixinyang, Cideciyan AV, Jacobson SG, Bennett J. Melatonin delays photoreceptor degeneration in the rds/rds mouse. Neuroreport. 12: 1011-1014. PMID 11303736 DOI: 10.1097/00001756-200104170-00029  0.489
2001 Liang FQ, Dejneka NS, Cohen DR, Krasnoperova NV, Lem J, Maguire AM, Dudus L, Fisher KJ, Bennett J. AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 241-8. PMID 11237681 DOI: 10.1006/Mthe.2000.0252  0.835
2000 Bennett J, Maguire AM. Gene therapy for ocular disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 501-5. PMID 10933974 DOI: 10.1006/Mthe.2000.0080  0.42
2000 Bennett J, Anand V, Acland GM, Maguire AM. Cross-species comparison of in vivo reporter gene expression after recombinant adeno-associated virus-mediated retinal transduction. Methods in Enzymology. 316: 777-89. PMID 10800714 DOI: 10.1016/S0076-6879(00)16762-X  0.448
2000 Bennett J, Zeng Y, Gupta AR, Maguire AM. Application of adenoviral vectors. Analysis of eye development. Methods in Molecular Biology (Clifton, N.J.). 135: 525-35. PMID 10791347 DOI: 10.1385/1-59259-685-1:525  0.602
2000 Anand V, Chirmule N, Fersh M, Maguire AM, Bennett J. Additional transduction events after subretinal readministration of recombinant adeno-associated virus. Human Gene Therapy. 11: 449-457. PMID 10697119 DOI: 10.1089/10430340050015914  0.312
2000 Haider NB, Jacobson SG, Cideciyan AV, Swiderski R, Streb LM, Searby C, Beck G, Hockey R, Hanna DB, Gorman S, Duhl D, Carmi R, Bennett J, Weleber RG, Fishman GA, et al. Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate. Nature Genetics. 24: 127-31. PMID 10655056 DOI: 10.1038/72777  0.52
1999 Nesbit M, Nesbit HK, Bennett J, Andl T, Hsu MY, Dejesus E, McBrian M, Gupta AR, Eck SL, Herlyn M. Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes. Oncogene. 18: 6469-76. PMID 10597249 DOI: 10.1038/Sj.Onc.1203066  0.567
1999 Dreyer EB, Vorwerk CK, Zurakowski D, Simon PD, Bennett J. Infection with adeno-associated virus may protect against excitotoxicity. Neuroreport. 10: 2887-90. PMID 10549791 DOI: 10.1097/00001756-199909290-00002  0.537
1999 Bennett J, Maguire AM, Cideciyan AV, Schnell M, Glover E, Anand V, Aleman TS, Chirmule N, Gupta AR, Huang Y, Gao GP, Nyberg WC, Tazelaar J, Hughes J, Wilson JM, et al. Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina. Proceedings of the National Academy of Sciences of the United States of America. 96: 9920-5. PMID 10449795 DOI: 10.1073/Pnas.96.17.9920  0.779
1999 Simon PD, Vorwerk CK, Mansukani SS, Chen SJ, Wilson JM, Zurakowski D, Bennett J, Dreyer EB. bcl-2 gene therapy exacerbates excitotoxicity. Human Gene Therapy. 10: 1715-20. PMID 10428216 DOI: 10.1089/10430349950017716  0.515
1999 Dudus L, Anand V, Acland GM, Chen SJ, Wilson JM, Fisher KJ, Maguire AM, Bennett J. Persistent transgene product in retina, optic nerve and brain after intraocular injection of rAAV. Vision Research. 39: 2545-53. PMID 10396623 DOI: 10.1016/S0042-6989(98)00308-3  0.577
1998 Bennett J, Zeng Y, Bajwa R, Klatt L, Li Y, Maguire A. Adenovirus-mediated delivery of rhodopsin-promoted bcl-2 results in a delay in photoreceptor cell death in the rd/rd mouse Gene Therapy. 5: 1156-1164. PMID 9930315 DOI: 10.1038/Sj.Gt.3300733  0.501
1998 Zeng Y, Rosborough RC, Li Y, Gupta AR, Bennett J. Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding gene. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 211: 228-37. PMID 9520110 DOI: 10.1002/(Sici)1097-0177(199803)211:3<228::Aid-Aja4>3.0.Co;2-J  0.614
1997 Buraczynska M, Wu W, Fujita R, Buraczynska K, Phelps E, Andréasson S, Bennett J, Birch DG, Fishman GA, Hoffman DR, Inana G, Jacobson SG, Musarella MA, Sieving PA, Swaroop A. Spectrum of mutations in the RPGR gene that are identified in 20% of families with X-linked retinitis pigmentosa. American Journal of Human Genetics. 61: 1287-92. PMID 9399904 DOI: 10.1086/301646  0.414
1997 Travis GH, Bennett J. The ABCs of AMD Nature Medicine. 3: 1196-1197. PMID 9359689 DOI: 10.1038/Nm1197-1196  0.321
1997 Forsythe P, Maguire A, Fujita R, Moen C, Swaroop A, Bennett J. A carboxy-terminal truncation of 99 amino acids resulting from a novel mutation (Arg555-->stop) in the CHM gene leads to choroideremia Experimental Eye Research. 64: 487-490. PMID 9196401 DOI: 10.1006/Exer.1996.0200  0.321
1997 Bennett J, Pakola S, Zeng Y, Maguire A. Humoral response after administration of E1-deleted adenoviruses: immune privilege of the subretinal space. Human Gene Therapy. 7: 1763-9. PMID 8886847 DOI: 10.1089/Hum.1996.7.14-1763  0.426
1996 Jacobson SG, Cideciyan AV, Maguire AM, Bennett J, Sheffield VC, Stone EM. Preferential rod and cone photoreceptor abnormalities in heterozygotes with point mutations in the RDS gene Experimental Eye Research. 63: 603-608. PMID 8994365 DOI: 10.1006/Exer.1996.0152  0.421
1996 Bennett J, Tanabe T, Sun D, Zeng Y, Kjeldbye H, Gouras P, Maguire AM. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy. Nature Medicine. 2: 649-54. PMID 8640555 DOI: 10.1038/Nm0696-649  0.47
1996 Bennett J, Sun D, Karikó K. Sequence analysis of the 5.34-kb 5' flanking region of the human rhodopsin-encoding gene. Gene. 167: 317-20. PMID 8566799 DOI: 10.1016/0378-1119(95)00688-5  0.353
1996 Bennett J, Tanabe T, Sun D, Zeng Y, Kjeldbye H, Gouras P. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy American Journal of Ophthalmology. 122: 607. DOI: 10.1016/S0002-9394(14)72143-9  0.536
1992 Wang Y, Macke JP, Merbs SL, Zack DJ, Klaunberg B, Bennett J, Gearhart J, Nathans J. A locus control region adjacent to the human red and green visual pigment genes. Neuron. 9: 429-40. PMID 1524826 DOI: 10.1016/0896-6273(92)90181-C  0.663
1991 Zack DJ, Bennett J, Wang Y, Davenport C, Klaunberg B, Gearhart J, Nathans J. Unusual topography of bovine rhodopsin promoter-lacZ fusion gene expression in transgenic mouse retinas. Neuron. 6: 187-99. PMID 1899580 DOI: 10.1016/0896-6273(91)90355-4  0.388
1984 Bennett J, Pedersen RA. Early mouse embryos exhibit strain variation in radiation-induced sister-chromatid exchange: relationship with DNA repair. Mutation Research. 126: 153-7. PMID 6538931 DOI: 10.1016/0027-5107(84)90057-5  0.49
1981 Bennett J, Mazia D. Fusion of fertilized and unfertilized sea urchin eggs. Maintenance of cell surface integrity. Experimental Cell Research. 134: 494-8. PMID 7196840 DOI: 10.1016/0014-4827(81)90454-7  0.549
1981 Bennett J, Mazia D. Interspecific fusion of sea urchin eggs. Surface events and cytoplasmic mixing. Experimental Cell Research. 131: 197-207. PMID 7004457 DOI: 10.1016/0014-4827(81)90419-5  0.552
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