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Henry Efrem Pelish

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2004 Harvard University, Cambridge, MA, United States 
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"Henry Pelish"
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Matthew D. Shair grad student 2004 Harvard
 (The chemistry and biology of secramine.)

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Liu ZJ, Thom C, Nitulescu II, et al. (2024) CDK8/19 inhibition triggers a switch from mitosis to endomitosis in cord blood megakaryocytes. British Journal of Haematology
Lin JJ, Horan JC, Tangpeerachaikul A, et al. (2024) NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. Cancer Discovery. OF1-OF20
Drilon A, Horan JC, Tangpeerachaikul A, et al. (2022) NVL-520 is a selective, TRK-sparing, and brain-penetrant inhibitor of ROS1 fusions and secondary resistance mutations. Cancer Discovery
Nitulescu II, Meyer SC, Wen QJ, et al. (2017) Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation. Ebiomedicine. 26: 112-125
Tahara T, Streit U, Pelish HE, et al. (2017) STAT3 Inhibitory Activity of Structurally Simplified Withaferin A Analogues. Organic Letters
Poss ZC, Ebmeier CC, Odell AT, et al. (2016) Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics. Cell Reports
Pelish HE, Liau BB, Nitulescu II, et al. (2015) Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature. 526: 273-6
Liu Z, Nitulescu I, Pelish H, et al. (2015) Mediator Kinase Inhibition Triggers a Phenotypic Switch from Neonatal to Adult-like Megakaryopoiesis Blood. 126: 1171-1171
Marks KM, Park ES, Arefolov A, et al. (2011) The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes. Journal of Natural Products. 74: 567-73
Kirchhausen T, Macia E, Pelish HE. (2008) Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods in Enzymology. 438: 77-93
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