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Angela N. Koehler, Ph.D.

Affiliations: 
2014- Biological Engineering Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Chemical biology, Deregulated transcription in disease
Website:
https://koehler-lab.mit.edu
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"Angela Koehler"
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Parents

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Arthur Glasfeld research assistant 1993-1997 Reed College
 (Undergraduate thesis advisor)
Stuart L. Schreiber grad student 2003 Harvard
 (Small molecule microarrays: A high -throughput tool for discovering protein-small molecule interactions.)

Children

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Nick Davis grad student MIT
Chuanxu Liu grad student MIT
Qiaoyi Wang grad student MIT
David B. Freeman grad student 2016- MIT
David B. Freeman grad student 2016- MIT
Nicholas Struntz grad student 2016- MIT
John Paul Shen grad student 2004-2005 Broad Institute (MIT/Harvard)
Mary Kathryn Doud grad student 2007-2010 Broad Institute (MIT/Harvard)
Clementine Feau grad student 2010-2012 Broad Institute (MIT/Harvard)
Melissa M. Kemp grad student 2009-2013 Broad Institute (MIT/Harvard)
Cheng Zhong grad student 2013-2013 Broad Institute (MIT/Harvard)
Rohit Thummalapalli grad student 2013-2015 MIT (Neurotree)
Francisco Caballero grad student 2012-2016 MIT
Jiyoung A. Hong grad student 2013-2016 MIT
Marius Pop grad student 2014-2016 MIT
Eric Stefan grad student 2014-2016 MIT
Thijs Wildschut grad student 2015-2016 MIT
Helen Evans grad student 2015-2017 MIT
Andre Richters grad student 2015-2017 MIT
Rui Traquette grad student 2016-2017 MIT

Collaborators

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Publications

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Annand JR, Henderson AR, Cole KS, et al. (2020) Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα. Acs Medicinal Chemistry Letters. 11: 1913-1918
Quinnell SP, Leifer BS, Nestor ST, et al. (2020) A Small-Molecule Inhibitor to the Cytokine Interleukin-4. Acs Chemical Biology
Chen A, Koehler AN. (2020) Transcription Factor Inhibition: Lessons Learned and Emerging Targets. Trends in Molecular Medicine. 26: 508-518
Struntz NB, Chen A, Deutzmann A, et al. (2019) Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription. Cell Chemical Biology
Leifer BS, Doyle SK, Richters A, et al. (2018) An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives. Methods in Enzymology. 610: 191-218
Richters A, Koehler AN. (2017) Epigenetic Modulation using Small Molecules - Targeting Histone Acetyltransferases in Disease. Current Medicinal Chemistry
Evans HL, Doyle SK, Pop MS, et al. (2017) Abstract 5221: Target engagement approaches to validate small-molecule binders of the pioneering transcription factor FOXA1 Cancer Research. 77: 5221-5221
Wang Y, Wach JY, Sheehan P, et al. (2016) Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β. Acs Medicinal Chemistry Letters. 7: 852-6
Yang Z, Koehler AN, Wang L. (2016) A novel small molecule activator of nuclear receptor SHP inhibits HCC cell migration via suppressing Ccl2. Molecular Cancer Therapeutics
Boskovic ZV, Kemp MM, Freedy AM, et al. (2016) Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile. Acs Chemical Biology
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