Xuechen Li, Ph.D.

Affiliations: 
2007 Harvard University, Cambridge, MA, United States 
Area:
molecular mechanisms of various antibiotics
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"Xuechen Li"
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Parents

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Daniel E. Kahne grad student 2007 Harvard
 (Total synthesis of moenomycin A; exploring different reactive intermediates during sulfoxide glycosylation.)
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Publications

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Martins A, Judák F, Farkas Z, et al. (2025) Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance. Science Translational Medicine. 17: eadl2103
Kang W, Zou T, Liang Y, et al. (2024) An integrated preventive and therapeutic magnetic nanoparticle loaded with rhamnolipid and vancomycin for combating subgingival biofilms. Dental Materials : Official Publication of the Academy of Dental Materials
Xiao Y, Zhou H, Liu H, et al. (2024) Trifluoroacetic Acid Mediated Additive-Free Late-Stage Native Peptide Cyclization to Form Disulfide Mimetics via Thioketalization with Ketones. Organic Letters
Xiao Y, Zhou H, Shi P, et al. (2024) Clickable tryptophan modification for late-stage diversification of native peptides. Science Advances. 10: eadp9958
Liu S, Tang Y, Chen S, et al. (2024) Total Syntheses of Streptamidine and Klebsazolicin Using Biomimetic On-Resin Ring-Closing Amidine Formation. Angewandte Chemie (International Ed. in English). e202407952
Wu H, Sun Z, Li X. (2024) Selective Peptide Cysteine Manipulation on Demand and Difficult Protein Chemical Synthesis Enabled by Controllable Acidolysis of N,S-Benzylidene Thioacetals. Angewandte Chemie (International Ed. in English). 63: e202403396
Wu H, Sun Z, Li X. (2023) N,O-Benzylidene Acetal Dipeptides (NBDs) Enable the Synthesis of Difficult Peptides via a Kinked Backbone Strategy. Angewandte Chemie (International Ed. in English). 62: e202310624
Sun Z, Wei T, Cao Y, et al. (2023) Protocol for semisynthesis of serotonylated histone H3 by rapid protein desulfurization in tandem with native chemical ligation. Star Protocols. 4: 102042
Wu H, Tan Y, Ngai WL, et al. (2023) Total synthesis of interleukin-2 a tunable backbone modification strategy. Chemical Science. 14: 1582-1589
Cheung CHP, Chong TH, Wei T, et al. (2023) Guanidine Additive Enabled Intermolecular ortho-Phthalaldehyde-Amine-Thiol Three-Component Reactions for Modular Constructions. Angewandte Chemie (International Ed. in English)
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