Michael B. Lazarus, Ph.D.
Affiliations: | 2010 | Harvard University, Cambridge, MA, United States |
Area:
molecular mechanisms of various antibioticsGoogle:
"Michael Lazarus"Mean distance: 8.43 | S | N | B | C | P |
Parents
Sign in to add mentor| Daniel E. Kahne | grad student | 2010 | Harvard | |
| (The structure and inhibition of O-GlcNActransferase.) | ||||
| Kevan Michael Shokat | post-doc | 2012-2015 | UCSF | |
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Publications
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| Leandro J, Khamrui S, Suebsuwong C, et al. (2022) Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1. Open Biology. 12: 220179 |
| Baidin V, Owens TW, Lazarus MB, et al. (2021) Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. Journal of the American Chemical Society |
| Leandro J, Khamrui S, Wang H, et al. (2020) Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. Acs Chemical Biology |
| Kumar K, Wang P, Wilson J, et al. (2020) Synthesis and Biological Validation of a Harmine-based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor. Journal of Medicinal Chemistry |
| Khamrui S, Ung PMU, Secor C, et al. (2019) High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4. Journal of the American Chemical Society |
| Martin SES, Tan ZW, Itkonen HM, et al. (2018) Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. Journal of the American Chemical Society |
| May JM, Owens TW, Mandler MD, et al. (2017) The antibiotic novobiocin binds and activates the ATPase that powers lipopolysaccharide transport. Journal of the American Chemical Society |
| Lazarus MB, Levin RS, Shokat KM. (2017) Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. Cellular Signalling. 29: 78-83 |
| Janetzko J, Trauger SA, Lazarus MB, et al. (2016) How the glycosyltransferase OGT catalyzes amide bond cleavage. Nature Chemical Biology |
| Lazarus MB, Shokat KM. (2015) Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Bioorganic & Medicinal Chemistry. 23: 5483-8 |