Brian A. Sparling, Ph.D.
Affiliations: | 2013 | Chemistry and Chemical Biology | Harvard University, Cambridge, MA, United States |
Area:
Organic synthesisGoogle:
"Brian Sparling"Mean distance: 7.73
Parents
Sign in to add mentor| Matthew D. Shair | grad student | 2013 | Harvard | |
| (Total Synthesis of Hyperforin.) | ||||
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Publications
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| Daniels MH, Castro J, Lee YT, et al. (2025) Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9. Journal of Medicinal Chemistry |
| Gao H, Schneider S, Andrews P, et al. (2019) Virtual screening to identify potent sepiapterin reductase inhibitors. Bioorganic & Medicinal Chemistry Letters. 126793 |
| Sparling BA, Yi S, Able J, et al. (2017) Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent Na1.7 inhibitors. Medchemcomm. 8: 744-754 |
| Graceffa RF, Boezio AA, Able J, et al. (2017) Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust In Vivo Activity. Journal of Medicinal Chemistry |
| Sparling BA, Tucker JK, Moebius DC, et al. (2015) Total Synthesis of (-)-Nemorosone and (+)-Secohyperforin. Organic Letters. 17: 3398-401 |
| Sparling BA, Moebius DC, Shair MD. (2013) Enantioselective total synthesis of hyperforin. Journal of the American Chemical Society. 135: 644-7 |