John C. Lukesh, Ph.D.
Affiliations: | 2017- | Department of Chemistry | Wake Forest University, Winston-Salem, NC, United States |
Area:
Medicinal Chemistry, Chemical BiologyWebsite:
https://lukeshjc.sites.wfu.eduGoogle:
"John Lukesh"Mean distance: 8.25 | S | N | B | C | P |
Parents
Sign in to add mentor| Ronald T. Raines | grad student | 2014 | UW Madison | |
| (Thiol–disulfide interchange: Design, synthesis, and evaluation of reagents and organocatalysts for chemical biology) | ||||
| Dale L. Boger | post-doc | 2014-2017 | Scripps Institute | |
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Publications
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| Hankins RA, Suarez SI, Kalk MA, et al. (2020) An Innovative Hydrogen Peroxide-Sensing Scaffold and Insight Towards its Potential as an ROS-Activated Persulfide Donor. Angewandte Chemie |
| Suarez SI, Warner CC, Brown-Harding H, et al. (2019) Highly selective staining and quantification of intracellular lipid droplets with a compact push-pull fluorophore based on benzothiadiazole. Organic & Biomolecular Chemistry |
| Suarez SI, Ambrose R, Kalk MA, et al. (2019) Selenosulfides Tethered to Gem-Dimethyl Esters: A Robust and Highly Versatile Framework for H₂S Probe Development. Chemistry (Weinheim An Der Bergstrasse, Germany) |
| Windsor IW, Palte MJ, Lukesh JC, et al. (2018) Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid. Journal of the American Chemical Society |
| Lukesh JC, Carney DW, Dong H, et al. (2017) Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance. Journal of Medicinal Chemistry |
| Yang S, Sankar K, Skepper CK, et al. (2017) Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity. Chemical Science. 8: 1560-1569 |
| Carney DW, Lukesh JC, Brody DM, et al. (2016) Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface. Proceedings of the National Academy of Sciences of the United States of America |
| Allemann O, Brutsch M, Lukesh JC, et al. (2016) Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity. Journal of the American Chemical Society |
| Lukesh JC, Andersen KA, Wallin KK, et al. (2014) Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase. Organic & Biomolecular Chemistry. 12: 8598-602 |
| Lukesh JC, Wallin KK, Raines RT. (2014) Pyrazine-derived disulfide-reducing agent for chemical biology. Chemical Communications (Cambridge, England). 50: 9591-4 |