Fraydoon Rastinejad
Affiliations: | 1995-2010 | University of Virginia, Charlottesville, VA | |
| 2018- | Nuffield Dept. of Medicine | University of Oxford, Oxford, United Kingdom |
Area:
Pharmacology, Medical Biophysics, BiochemistryWebsite:
https://www.bnc.ox.ac.uk/about-brasenose/academic-staff/592-professor-fraydoon-rastinejadGoogle:
"Fraydoon Rastinejad"Bio:
https://www.ndm.ox.ac.uk/team/fraydoon-rastinejad
https://www.proquest.com/openview/6a1356f7c2ae50bc3b21ef4df6e24c01/1
Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Ponzy Lu | grad student | 1992 | Penn | |
| (Gene expression: Protein-DNA interactions probed by fluorine-19 NMR) | ||||
| Paul B. Sigler | post-doc | 1992-1995 | Yale | |
Children
Sign in to add trainee| Michael L. Sierk | grad student | 2001 | UVA |
| Srikripa Devarakonda | grad student | 2004 | UVA |
| Li-Zhi Mi | grad student | 2004 | UVA |
| Srilatha Raghuram | grad student | 2008 | UVA |
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Publications
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| Diao X, Shang Q, Guo M, et al. (2025) Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex. Nature Communications. 16: 1282 |
| Rastinejad F. (2024) Allosteric communications between domains of nuclear receptors. Steroids. 214: 109551 |
| Zhuang J, Shang Q, Rastinejad F, et al. (2023) Decoding Allosteric Control in Hypoxia-Inducible Factors. Journal of Molecular Biology. 168352 |
| Rastinejad F. (2023) The protein architecture and allosteric landscape of HNF4α. Frontiers in Endocrinology. 14: 1219092 |
| Ondrová K, Zůvalová I, Vyhlídalová B, et al. (2023) Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice. Nature Communications. 14: 2728 |
| Sun X, Jing L, Li F, et al. (2022) Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208804119 |
| Rastinejad F. (2022) Retinoic acid receptor structures: the journey from single domains to the full-length complex. Journal of Molecular Endocrinology |
| Daniel B, Nagy G, Czimmerer Z, et al. (2018) The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory. Immunity. 49: 615-626.e6 |
| Chandra V, Wu D, Li S, et al. (2017) The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission. Nature Communications. 8: 868 |
| Wu D, Su X, Potluri N, et al. (2016) NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. Elife. 5 |