Fraydoon Rastinejad

Affiliations: 
University of Virginia, Charlottesville, VA 
Area:
Pharmacology, Medical Biophysics, Biochemistry
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Children

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Michael L. Sierk grad student 2001 UVA
Srikripa Devarakonda grad student 2004 UVA
Li-Zhi Mi grad student 2004 UVA
Srilatha Raghuram grad student 2008 UVA
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Publications

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Zhuang J, Shang Q, Rastinejad F, et al. (2023) Decoding Allosteric Control in Hypoxia-Inducible Factors. Journal of Molecular Biology. 168352
Rastinejad F. (2023) The protein architecture and allosteric landscape of HNF4α. Frontiers in Endocrinology. 14: 1219092
Ondrová K, Zůvalová I, Vyhlídalová B, et al. (2023) Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice. Nature Communications. 14: 2728
Sun X, Jing L, Li F, et al. (2022) Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208804119
Rastinejad F. (2022) Retinoic acid receptor structures: the journey from single domains to the full-length complex. Journal of Molecular Endocrinology
Daniel B, Nagy G, Czimmerer Z, et al. (2018) The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory. Immunity. 49: 615-626.e6
Chandra V, Wu D, Li S, et al. (2017) The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission. Nature Communications. 8: 868
Wu D, Su X, Potluri N, et al. (2016) NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. Elife. 5
Wu D, Rastinejad F. (2016) Structural characterization of mammalian bHLH-PAS transcription factors. Current Opinion in Structural Biology. 43: 1-9
Khorasanizadeh S, Rastinejad F. (2016) Visualizing the Architectures and Interactions of Nuclear Receptors. Endocrinology. en20161559
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