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William C. Groutas

Affiliations: 
Wichita State University, Wichita, KS, United States 
Area:
Biochemistry, Pharmaceutical Chemistry
Website:
https://www.wichita.edu/academics/fairmount_college_of_liberal_arts_and_sciences/chemistry/People/Groutas/main.php
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"William Groutas"
Bio:

https://books.google.com/books?id=bwsoAQAAIAAJ

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Parents

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John Miles Patterson grad student 1973 University of Kentucky
Walter T. Smith grad student 1973 University of Kentucky
 (Base-induced reactions of some activated halides in dipolar aprotic solvents.)

Children

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Shu He grad student 2000 Wichita State University
Pathum Weerawarna grad student 2011-2016 Wichita State University
Anushka Galasiti Kankanamalage grad student 2012-2017 Wichita State University
Athri D. Rathnayake grad student 2015-2020 Wichita State University

Collaborators

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Keyong O-K Chang collaborator Kansas State University
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Publications

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Kim Y, Pool E, Kim E, et al. (2024) Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus. Microbiology Spectrum. e0337223
Li P, Kim Y, Dampalla CS, et al. (2023) Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment. Mbio. e0287823
Dampalla CS, Miller MJ, Kim Y, et al. (2023) Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV). European Journal of Medicinal Chemistry. 254: 115376
Dampalla CS, Nguyen HN, Rathnayake AD, et al. (2022) Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies. Acs Pharmacology & Translational Science. 6: 181-194
Perera KD, Johnson D, Lovell S, et al. (2022) Potent Protease Inhibitors of Highly Pathogenic Lagoviruses: Rabbit Hemorrhagic Disease Virus and European Brown Hare Syndrome Virus. Microbiology Spectrum. e0014222
Dampalla CS, Rathnayake AD, Galasiti Kankanamalage AC, et al. (2022) Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease. Journal of Medicinal Chemistry. 65: 7818-7832
Dampalla CS, Rathnayake AD, Perera KD, et al. (2021) Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies. Journal of Medicinal Chemistry
Dampalla CS, Kim Y, Bickmeier N, et al. (2021) Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease. Journal of Medicinal Chemistry
Dampalla CS, Zheng J, Perera KD, et al. (2021) Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection. Proceedings of the National Academy of Sciences of the United States of America. 118
Rathnayake AD, Kim Y, Dampalla CS, et al. (2020) Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease. Journal of Medicinal Chemistry
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