☰ Chemistry Tree

Carl O. Pabo

Affiliations:

Massachusetts Institute of Technology, Cambridge, MA, United States

Area:

protein-DNA recognition

Website:

http://www.hhmi.org/research/investigators/pabo_bio.html

Google:

Bio:

http://www.nasonline.org/member-directory/members/59647.html
http://www.proteanfutures.com/

Mean distance: 7.74

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Parents

Mark Ptashne	grad student	1980	Harvard
(Structural study of the lambda repressor)
Stephen C. Harrison	post-doc		Harvard
Don C. Wiley	post-doc		Harvard

Children

Ernest Fraenkel	grad student		MIT (Plant Biology Tree)
Alan D. Frankel	grad student
Jin-Soo Kim	grad student
Nikola P. Pavletich	grad student	1991	Johns Hopkins Medical School
Lisa C. Tucker-Kellogg	grad student	1993-1997	(Neurotree)
Nikola P. Pavletich	post-doc		MIT
Cynthia Wolberger	post-doc		Johns Hopkins
H. Eric Xu	post-doc

Collaborators

BETA: Related publications

Publications

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Nguyen-Hackley DH, Ramm E, Taylor CM, et al. (2004) Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. Biochemistry. 43: 3880-90
Wolfe SA, Grant RA, Pabo CO. (2003) Structure of a designed dimeric zinc finger protein bound to DNA. Biochemistry. 42: 13401-9
Hurt JA, Thibodeau SA, Hirsh AS, et al. (2003) Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection. Proceedings of the National Academy of Sciences of the United States of America. 100: 12271-6
Peisach E, Pabo CO. (2003) Constraints for zinc finger linker design as inferred from X-ray crystal structure of tandem Zif268-DNA complexes. Journal of Molecular Biology. 330: 1-7
Jamieson AC, Miller JC, Pabo CO. (2003) Drug discovery with engineered zinc-finger proteins. Nature Reviews. Drug Discovery. 2: 361-8
Miller JC, Pabo CO. (2001) Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition. Journal of Molecular Biology. 313: 309-15
Wolfe SA, Grant RA, Elrod-Erickson M, et al. (2001) Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes. Structure (London, England : 1993). 9: 717-23
Wang BS, Grant RA, Pabo CO. (2001) Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA. Nature Structural Biology. 8: 589-93
Pabo CO, Peisach E, Grant RA. (2001) Design and selection of novel Cys2His2 zinc finger proteins. Annual Review of Biochemistry. 70: 313-40
Pabo CO, Nekludova L. (2000) Geometric analysis and comparison of protein-DNA interfaces: why is there no simple code for recognition? Journal of Molecular Biology. 301: 597-624

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