James Staunton

Affiliations: 
Chemistry University of Cambridge, Cambridge, England, United Kingdom 
Website:
http://www.ch.cam.ac.uk/person/js24
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"James Staunton"
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Publications

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Hong H, Leadlay PF, Staunton J. (2009) The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry. The Febs Journal. 276: 7057-69
Kellenberger L, Galloway IS, Sauter G, et al. (2008) A polylinker approach to reductive loop swaps in modular polyketide synthases. Chembiochem : a European Journal of Chemical Biology. 9: 2740-9
Demydchuk Y, Sun Y, Hong H, et al. (2008) Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. Chembiochem : a European Journal of Chemical Biology. 9: 1136-45
Harvey BM, Hong H, Jones MA, et al. (2006) Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin. Chembiochem : a European Journal of Chemical Biology. 7: 1435-42
Gallimore AR, Stark CB, Bhatt A, et al. (2006) Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis. Chemistry & Biology. 13: 453-60
Siskos AP, Baerga-Ortiz A, Bali S, et al. (2005) Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chemistry & Biology. 12: 1145-53
Bhatt A, Stark CB, Harvey BM, et al. (2005) Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked. Angewandte Chemie (International Ed. in English). 44: 7075-8
Hong H, Appleyard AN, Siskos AP, et al. (2005) Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry. The Febs Journal. 272: 2373-87
Moseley JD, Staunton J. (2005) Preparation of dicarboxylate analogues of Cerulenin Journal of Heterocyclic Chemistry. 42: 819-830
Boakes S, Oliynyk M, Cortés J, et al. (2004) A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea. Journal of Molecular Microbiology and Biotechnology. 8: 73-80
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