Andrew D. Mesecar

Molecular Biosciences Purdue University, West Lafayette, IN, United States 
molecular mechanisms and function of therapeutic enzymes and proteins
"Andrew D. Mesecar"

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Thomas L. Nowak grad student 1995 Notre Dame
 (Kinetic responses and conformational changes required for yeast pyruvate kinase activation and catalysis)
Daniel E. Koshland post-doc 1995-1998 UC Berkeley
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Ghosh AK, Shahabi D, Imhoff MEC, et al. (2023) SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads. Bioorganic & Medicinal Chemistry Letters. 96: 129489
Bose S, Steussy CN, López-Pérez D, et al. (2023) Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor. Communications Biology. 6: 360
Ghosh AK, Shahabi D, Yadav M, et al. (2021) Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors. Molecules (Basel, Switzerland). 26
Ghosh AK, Raghavaiah J, Shahabi D, et al. (2021) Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. Journal of Medicinal Chemistry
Yen YC, Kammeyer A, Jensen KC, et al. (2019) Development of an efficient enzyme production and structure-based discovery platform for BACE1 inhibitors. Biochemistry
Hjortland NM, Mesecar AD. (2016) Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme. Archives of Biochemistry and Biophysics. 612: 35-45
St John SE, Tomar S, Stauffer SR, et al. (2015) Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). Bioorganic & Medicinal Chemistry. 23: 6036-48
Báez-Santos YM, St John SE, Mesecar AD. (2015) The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds. Antiviral Research. 115: 21-38
Zhai X, Go MK, O'Donoghue AC, et al. (2014) Enzyme architecture: the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase. Biochemistry. 53: 3486-501
Báez-Santos YM, Barraza SJ, Wilson MW, et al. (2014) X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. Journal of Medicinal Chemistry. 57: 2393-412
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