Geoffrey Wells, PhD

Affiliations: 
1998 Cancer Research Laboratories, School of Pharmaceutical Sciences University of Nottingham, Nottingham, England, United Kingdom 
 1998-2002 The School of Pharmacy University of London, London, England, United Kingdom 
 2002-2004 Pharminox Ltd 
 2007- School of Pharmacy University College London, London, United Kingdom 
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"Geoffrey Wells"
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Breen AF, Wells G, Turyanska L, et al. (2019) Development of novel apoferritin formulations for antitumour benzothiazoles. Cancer Reports (Hoboken, N.J.). 2: e1155
Breen AF, Scurr D, Cassioli ML, et al. (2019) Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery. International Journal of Nanomedicine. 14: 9525-9534
Shih PC, Yang Y, Parkinson GN, et al. (2018) A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3). Oncotarget. 9: 32690-32701
König J, Wyllie S, Wells G, et al. (2011) Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism. The Journal of Biological Chemistry. 286: 8523-33
McCarroll AJ, Matthews CS, Wells G, et al. (2010) Synthesis of antitumour (1H-1,2,3-triazol-4-yl)-4-hydroxycyclohexa-2,5-dien-1-ones by copper-catalysed Huisgen cycloadditions. Organic & Biomolecular Chemistry. 8: 2078-84
Aiello S, Wells G, Stone EL, et al. (2008) Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648). Journal of Medicinal Chemistry. 51: 5135-9
Lion CJ, Matthews CS, Wells G, et al. (2006) Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols'). Bioorganic & Medicinal Chemistry Letters. 16: 5005-8
Mortimer CG, Wells G, Crochard JP, et al. (2006) Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. Journal of Medicinal Chemistry. 49: 179-85
Bradshaw TD, Matthews CS, Cookson J, et al. (2005) Elucidation of thioredoxin as a molecular target for antitumor quinols. Cancer Research. 65: 3911-9
Berry JM, Bradshaw TD, Fichtner I, et al. (2005) Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents. Journal of Medicinal Chemistry. 48: 639-44
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