Year |
Citation |
Score |
2020 |
Jílková A, Rubešová P, Fanfrlík J, Fajtová P, Řezáčová P, Brynda J, Lepšík M, Mertlíková-Kaiserová H, Emal CD, Renslo AR, Roush WR, Horn M, Caffrey CR, Mareš M. Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors. Acs Infectious Diseases. PMID 33175511 DOI: 10.1021/acsinfecdis.0c00501 |
0.475 |
|
2018 |
Reinke AA, Li SH, Warnock M, Shaydakov ME, Guntaka NS, Su EJ, Diaz JA, Emal CD, Lawrence DA. Dual-reporter high-throughput screen for small-molecule inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate. The Journal of Biological Chemistry. PMID 30510136 DOI: 10.1074/jbc.RA118.004885 |
0.372 |
|
2013 |
Li SH, Reinke AA, Sanders KL, Emal CD, Whisstock JC, Stuckey JA, Lawrence DA. Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proceedings of the National Academy of Sciences of the United States of America. 110: E4941-9. PMID 24297881 DOI: 10.1073/pnas.1216499110 |
0.34 |
|
2010 |
Cale JM, Li SH, Warnock M, Su EJ, North PR, Sanders KL, Puscau MM, Emal CD, Lawrence DA. Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1. The Journal of Biological Chemistry. 285: 7892-902. PMID 20061381 DOI: 10.1074/jbc.M109.067967 |
0.481 |
|
2010 |
El-Ayache NC, Li SH, Warnock M, Lawrence DA, Emal CD. Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1). Bioorganic & Medicinal Chemistry Letters. 20: 966-70. PMID 20056540 DOI: 10.1016/j.bmcl.2009.12.051 |
0.524 |
|
2003 |
Boitano A, Emal CD, Leonetti F, Blatt NB, Dineen TA, Ellman JA, Roush WR, Opipari AW, Glick GD. Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters. 13: 3327-30. PMID 12951119 DOI: 10.1016/S0960-894X(03)00683-8 |
0.426 |
|
2003 |
Shenai BR, Lee BJ, Alvarez-Hernandez A, Chong PY, Emal CD, Neitz RJ, Roush WR, Rosenthal PJ. Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones. Antimicrobial Agents and Chemotherapy. 47: 154-60. PMID 12499184 DOI: 10.1128/Aac.47.1.154-160.2003 |
0.477 |
|
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