Thomas A. Dineen - Publications

Affiliations: 
2005 University of Michigan, Ann Arbor, Ann Arbor, MI 

14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Chen JJ, Liu Q, Yuan C, Gore V, Lopez P, Ma V, Amegadzie A, Qian W, Judd TC, Minatti AE, Brown J, Cheng Y, Xue M, Zhong W, Dineen TA, et al. Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 25: 767-74. PMID 25613679 DOI: 10.1016/j.bmcl.2014.12.092  1
2014 Epstein O, Bryan MC, Cheng AC, Derakhchan K, Dineen TA, Hickman D, Hua Z, Human JB, Kreiman C, Marx IE, Weiss MM, Wahl RC, Wen PH, Whittington DA, Wood S, et al. Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors. Journal of Medicinal Chemistry. 57: 9796-810. PMID 25389560 DOI: 10.1021/jm501266w  1
2014 Dineen TA, Chen K, Cheng AC, Derakhchan K, Epstein O, Esmay J, Hickman D, Kreiman CE, Marx IE, Wahl RC, Wen PH, Weiss MM, Whittington DA, Wood S, Fremeau RT, et al. Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718). Journal of Medicinal Chemistry. 57: 9811-31. PMID 25363711 DOI: 10.1021/jm5012676  1
2012 Huang H, La DS, Cheng AC, Whittington DA, Patel VF, Chen K, Dineen TA, Epstein O, Graceffa R, Hickman D, Kiang YH, Louie S, Luo Y, Wahl RC, Wen PH, et al. Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease. Journal of Medicinal Chemistry. 55: 9156-69. PMID 22928914 DOI: 10.1021/jm300598e  1
2012 Wood S, Wen PH, Zhang J, Zhu L, Luo Y, Babu-Khan S, Chen K, Pham R, Esmay J, Dineen TA, Kaller MR, Weiss MM, Hitchcock SA, Citron M, Zhong W, et al. Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 343: 460-7. PMID 22911925 DOI: 10.1124/jpet.112.197954  1
2012 Dineen TA, Weiss MM, Williamson T, Acton P, Babu-Khan S, Bartberger MD, Brown J, Chen K, Cheng Y, Citron M, Croghan MD, Dunn RT, Esmay J, Graceffa RF, Harried SS, et al. Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors. Journal of Medicinal Chemistry. 55: 9025-44. PMID 22468684 DOI: 10.1021/jm300118s  1
2012 Weiss MM, Williamson T, Babu-Khan S, Bartberger MD, Brown J, Chen K, Cheng Y, Citron M, Croghan MD, Dineen TA, Esmay J, Graceffa RF, Harried SS, Hickman D, Hitchcock SA, et al. Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid. Journal of Medicinal Chemistry. 55: 9009-24. PMID 22468639 DOI: 10.1021/jm300119p  1
2011 Plant M, Dineen T, Cheng A, Long AM, Chen H, Morgenstern KA. Screening for lysine-specific demethylase-1 inhibitors using a label-free high-throughput mass spectrometry assay. Analytical Biochemistry. 419: 217-27. PMID 21855527 DOI: 10.1016/j.ab.2011.07.002  1
2009 Michaelis DJ, Dineen TA. Ring opening of aziridines with ortho-bromophenyl metal reagents: synthesis of 2-substituted indolines Tetrahedron Letters. 50: 1920-1923. DOI: 10.1016/j.tetlet.2009.02.047  1
2006 Dineen TA, Zajac MA, Myers AG. Efficient transamidation of primary carboxamides by in situ activation with N,N-dialkylformamide dimethyl acetals. Journal of the American Chemical Society. 128: 16406-9. PMID 17165798 DOI: 10.1021/ja066728i  0.52
2005 Dineen TA, Roush WR. Stereoselective synthesis of the octahydronaphthalene unit of integramycin via an intramolecular Diels-Alder reaction. Organic Letters. 7: 1355-8. PMID 15787505 DOI: 10.1021/ol050191g  1
2004 Dineen TA, Roush WR. Total synthesis of cochleamycin A. Organic Letters. 6: 2043-6. PMID 15176814 DOI: 10.1021/ol049331x  1
2003 Dineen TA, Roush WR. Probing the Lewis acid-catalyzed intramolecular Diels-Alder cyclizations of allylic alkoxy-substituted (Z)-1,3-dienes. Organic Letters. 5: 4725-8. PMID 14627425 DOI: 10.1021/ol035900+  1
2003 Boitano A, Emal CD, Leonetti F, Blatt NB, Dineen TA, Ellman JA, Roush WR, Opipari AW, Glick GD. Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters. 13: 3327-30. PMID 12951119 DOI: 10.1016/S0960-894X(03)00683-8  1
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