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Michael G. Zagorski, Ph.D. - Publications

Affiliations: 
1983-1986 Chemistry Columbia University, New York, NY 
 1989-1992 Suntory Institute for Bioorganic Research 
 1992- Chemistry Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
Protein misfolding, amyloid formation
Website:
http://chemistry.case.edu/faculty/michael-zagorski/
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60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Pappolla MA, Matsubara E, Vidal R, Pacheco-Quinto J, Poeggeler B, Zagorski M, Sambamurti K. Melatonin treatment enhances Aβ lymphatic clearance in a transgenic mouse model of amyloidosis. Current Alzheimer Research. PMID 29637859 DOI: 10.2174/1567205015666180411092551  0.349
2013 Hou L, Lee HG, Han F, Tedesco JM, Perry G, Smith MA, Zagorski MG. Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation. Journal of Alzheimer's Disease : Jad. 37: 9-18. PMID 23719512 DOI: 10.3233/Jad-122389  0.765
2013 Ono K, Li L, Takamura Y, Yoshiike Y, Ikeda T, Takasaki J, Nishijo H, Takashima A, Teplow D, Zagorski M, Yamada M. Phenolic compounds prevent beta-amyloid-protein oligomerization and synaptic dysfunction by site-specific binding Alzheimers & Dementia. 9: 361. DOI: 10.1016/J.Jalz.2013.05.690  0.314
2012 Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki J, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M. Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. The Journal of Biological Chemistry. 287: 14631-43. PMID 22393064 DOI: 10.1074/Jbc.M111.325456  0.325
2009 Bhaskar K, Miller M, Chludzinski A, Herrup K, Zagorski M, Lamb BT. The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Molecular Neurodegeneration. 4: 14. PMID 19291319 DOI: 10.1186/1750-1326-4-14  0.306
2009 Salomon R, Zagorski M. In Memoriam: Lawrence (Larry) M. Sayre Chemical Research in Toxicology. 22: 1369-1371. DOI: 10.1021/Tx900204Z  0.432
2009 Zagorski MG. O2-06-06: Micelle-like structures during the early-stages of Aβ(1-40) and Aβ(1-42) Association Alzheimer's & Dementia. 5: P116-P116. DOI: 10.1016/J.Jalz.2009.05.366  0.343
2008 Friedland RP, Tedesco JM, Wilson AC, Atwood CS, Smith MA, Perry G, Zagorski MG. Antibodies to potato virus Y bind the amyloid beta peptide: immunohistochemical and NMR studies. The Journal of Biological Chemistry. 283: 22550-6. PMID 18505725 DOI: 10.1074/Jbc.M802088200  0.759
2008 Zagorski MG, Li L, Hou L, Miller M, Bhaskar K, Anderson V, Mann J, Lamb B. P1-431: Production of micelle-like structures during the early stages of Aβ(1-40) and Aβ(1-42) association Alzheimer's & Dementia. 4: T346-T346. DOI: 10.1016/J.Jalz.2008.05.1013  0.585
2006 Hou L, Zagorski MG. NMR reveals anomalous copper(II) binding to the amyloid Abeta peptide of Alzheimer's disease. Journal of the American Chemical Society. 128: 9260-1. PMID 16848423 DOI: 10.1021/Ja046032U  0.62
2006 Apetri MM, Maiti NC, Zagorski MG, Carey PR, Anderson VE. Secondary structure of alpha-synuclein oligomers: characterization by raman and atomic force microscopy. Journal of Molecular Biology. 355: 63-71. PMID 16303137 DOI: 10.1016/J.Jmb.2005.10.071  0.773
2004 Srinivasan R, Marchant RE, Zagorski MG. ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 11: 10-3. PMID 15185493 DOI: 10.1080/13506120410001667872  0.629
2004 Maiti NC, Apetri MM, Zagorski MG, Carey PR, Anderson VE. Raman spectroscopic characterization of secondary structure in natively unfolded proteins: alpha-synuclein. Journal of the American Chemical Society. 126: 2399-408. PMID 14982446 DOI: 10.1021/Ja0356176  0.761
2004 Hou L, Shao H, Zhang Y, Li H, Menon NK, Neuhaus EB, Brewer JM, Byeon IJ, Ray DG, Vitek MP, Iwashita T, Makula RA, Przybyla AB, Zagorski MG. Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. Journal of the American Chemical Society. 126: 1992-2005. PMID 14971932 DOI: 10.1021/Ja036813F  0.724
2004 Hou L, Zagorski MG. Sorting out the driving forces for parallel and antiparallel alignment in the abeta peptide fibril structure. Biophysical Journal. 86: 1-2. PMID 14695243 DOI: 10.1016/S0006-3495(04)74077-1  0.665
2004 Zagorski MG, Hou L, Shao H, Zhang Y, Menon N. P1-200 Solution NMR studies of the AB(1-40) and AB(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation Neurobiology of Aging. 25: S153. DOI: 10.1016/S0197-4580(04)80513-X  0.712
2003 Srinivasan R, Jones EM, Liu K, Ghiso J, Marchant RE, Zagorski MG. pH-dependent amyloid and protofibril formation by the ABri peptide of familial British dementia. Journal of Molecular Biology. 333: 1003-23. PMID 14583196 DOI: 10.1016/J.Jmb.2003.09.001  0.631
2002 Hou L, Kang I, Marchant RE, Zagorski MG. Methionine 35 oxidation reduces fibril assembly of the amyloid abeta-(1-42) peptide of Alzheimer's disease. The Journal of Biological Chemistry. 277: 40173-6. PMID 12198111 DOI: 10.1074/Jbc.C200338200  0.643
2002 Adams PD, Chen Y, Ma K, Zagorski MG, Sönnichsen FD, McLaughlin ML, Barkley MD. Intramolecular quenching of tryptophan fluorescence by the peptide bond in cyclic hexapeptides. Journal of the American Chemical Society. 124: 9278-86. PMID 12149035 DOI: 10.1021/Ja0167710  0.338
2001 Poeggeler B, Miravalle L, Zagorski MG, Wisniewski T, Chyan YJ, Zhang Y, Shao H, Bryant-Thomas T, Vidal R, Frangione B, Ghiso J, Pappolla MA. Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide. Biochemistry. 40: 14995-5001. PMID 11732920 DOI: 10.1021/Bi0114269  0.634
2001 Zeng H, Zhang Y, Peng L, Shao H, Menon NK, Yang J, Salomon AR, Freidland RP, Zagorski MG. Nicotine and amyloid formation. Biological Psychiatry. 49: 248-57. PMID 11230876 DOI: 10.1016/S0006-3223(00)01111-2  0.656
2000 Zhang Y, Swietnicki W, Zagorski MG, Surewicz WK, Sönnichsen FD. Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases. The Journal of Biological Chemistry. 275: 33650-4. PMID 10954699 DOI: 10.1074/Jbc.C000483200  0.572
2000 Zagorski MG, Shao H, Ma K, Yang J, Li H, Zeng H, Zhang Y, Papolla M. Amyloid AB (1–40) and AB(1–42) adopt remarkably stable, monomeric, and extended structures in water solution at neutral pH Neurobiology of Aging. 21: 10-11. DOI: 10.1016/S0197-4580(00)82724-4  0.548
1999 Zagorski MG, Yang J, Shao H, Ma K, Zeng H, Hong A. Methodological and chemical factors affecting amyloid beta peptide amyloidogenicity. Methods in Enzymology. 309: 189-204. PMID 10507025 DOI: 10.1016/S0076-6879(99)09015-1  0.373
1999 Shao H, Jao S, Ma K, Zagorski MG. Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease. Journal of Molecular Biology. 285: 755-73. PMID 9878442 DOI: 10.1006/Jmbi.1998.2348  0.442
1999 Ma K, Clancy EL, Zhang Y, Ray DG, Wollenberg K, Zagorski MG. Residue-specific pK(a) measurements of the β-peptide and mechanism of pH-induced amyloid formation Journal of the American Chemical Society. 121: 8698-8706. DOI: 10.1021/Ja990864O  0.605
1998 Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. The Journal of Biological Chemistry. 273: 7185-8. PMID 9516407 DOI: 10.1074/Jbc.273.13.7185  0.423
1998 Marcinowski KJ, Shao H, Clancy EL, Zagorski MG. Solution structure model of residues 1-28 of the amyloid β-peptide when bound to micelles Journal of the American Chemical Society. 120: 11082-11091. DOI: 10.1021/Ja9738687  0.441
1997 Sayre LM, Zagorski MG, Surewicz WK, Krafft GA, Perry G. Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal. Chemical Research in Toxicology. 10: 518-26. PMID 9168248 DOI: 10.1021/Tx970009N  0.363
1997 Jao SC, Ma K, Talafous J, Orlando R, Zagorski MG. Trifluoroacetic acid pretreatment reproducibly disaggregates the amyloid β-peptide Amyloid. 4: 240-252. DOI: 10.3109/13506129709003835  0.791
1996 Salomon AR, Marcinowski KJ, Friedland RP, Zagorski MG. Nicotine inhibits amyloid formation by the beta-peptide. Biochemistry. 35: 13568-78. PMID 8885836 DOI: 10.1021/Bi9617264  0.447
1996 Zagorski M, Marcinowski K, Jan S, Shao H, Salomon A, Clancy E, Ma K, Lantz M, Talafous J. 743 The solution structure of the amyloid β-(1–42) peptide provides a molecular approach for the treatment of Alzheimer's Disease Neurobiology of Aging. 17: S184-S185. DOI: 10.1016/S0197-4580(96)80745-7  0.782
1994 Talafous J, Marcinowski KJ, Klopman G, Zagorski MG. Solution structure of residues 1-28 of the amyloid beta-peptide. Biochemistry. 33: 7788-96. PMID 7516706 DOI: 10.1021/Bi00191A006  0.798
1992 Barrow CJ, Yasuda A, Kenny PT, Zagorski MG. Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra. Journal of Molecular Biology. 225: 1075-93. PMID 1613791 DOI: 10.1016/0022-2836(92)90106-T  0.427
1992 Zagorski MG, Barrow CJ. NMR studies of amyloid beta-peptides: proton assignments, secondary structure, and mechanism of an alpha-helix----beta-sheet conversion for a homologous, 28-residue, N-terminal fragment. Biochemistry. 31: 5621-31. PMID 1610809 DOI: 10.1021/Bi00139A028  0.459
1992 Orlando R, Kenny PT, Zagorski MG. Covalent modification of Alzheimer's amyloid beta-peptide in formic acid solutions. Biochemical and Biophysical Research Communications. 184: 686-91. PMID 1575742 DOI: 10.1016/0006-291X(92)90644-Z  0.435
1991 Zagorski MG, Norman DG, Barrow CJ, Iwashita T, Tachibana K, Patel DJ. Solution structure of pardaxin P-2. Biochemistry. 30: 8009-17. PMID 1868074 DOI: 10.1021/Bi00246A019  0.374
1991 Barrow CJ, Zagorski MG. Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition. Science (New York, N.Y.). 253: 179-82. PMID 1853202 DOI: 10.1126/Science.1853202  0.407
1989 Zagorski MG, Bowie JU, Vershon AK, Sauer RT, Patel DJ. NMR studies of Arc repressor mutants: proton assignments, secondary structure, and long-range contacts for the thermostable proline-8----leucine variant of Arc. Biochemistry. 28: 9813-25. PMID 2611267 DOI: 10.1021/Bi00451A041  0.386
1989 Lee MS, Qin GW, Nakanishi K, Zagorski MG. Biosynthetic studies of brevetoxins, potent neurotoxins produced by the dinoflagellate Gymnodinium breve Journal of the American Chemical Society. 111: 6234-6241. DOI: 10.1021/Ja00198A039  0.381
1988 Zagorski MG, Nakanishi K, Qin GW, Lee MS. Assignment of carbon-13 NMR peaks of brevetoxin A: application of two-dimensional Hartmann-Hahn spectroscopy Journal of Organic Chemistry. 53: 4156-4158. DOI: 10.1021/Jo00252A068  0.429
1988 Marston A, Zagorski MG, Hostettmann K. Antifungal Polyphenols fromCordia goetzeiGürke Helvetica Chimica Acta. 71: 1210-1219. DOI: 10.1002/Hlca.19880710532  0.468
1988 Zagorski MG, Nakanishi K, Qin GW, Lee MS. Assignment of 13C NMR peaks of brevetoxin A: Application of two-dimensional hartmann-hahn spectroscopy Journal of Organic Chemistry. 53: 4156-4158.  0.352
1987 Pawlak J, Tempesta MS, Golik J, Zagorski MG, Lee MS, Nakanishi K, Iwashita T, Gross ML, Tomer KB. Structure of brevetoxin A as constructed from NMR and mass spectral data Journal of the American Chemical Society. 109: 1144-1150. DOI: 10.1021/Ja00238A025  0.76
1987 Turner CJ, Tempesta MS, Taylor RB, Zagorski MG, Termini JS, Schroeder DR, Nakanishi K. An NMR spectroscopic study of azadirachtin and its trimethyl ether Tetrahedron. 43: 2789-2803. DOI: 10.1016/S0040-4020(01)86885-X  0.766
1987 PAWLAK J, TEMPESTA MS, GOLIK J, ZAGORSKI MG, LEE MS, NAKANISHI K, IWASHITA T, GROSS ML, TOMER KB. ChemInform Abstract: Structure of Brevetoxin A as Constructed from NMR and MS Data Cheminform. 18. DOI: 10.1002/chin.198726331  0.754
1987 Pawlak J, Tempesta MS, Golik J, Zagorski MG, Lee MS, Nakanishi K, Iwashita T, Gross ML, Tomer KB. Structure of brevetoxin A as constructed from NMR and MS data Journal of the American Chemical Society. 109: 1144-1150.  0.753
1986 Lee MS, Repeta DJ, Nakanishi K, Zagorski MG. Biosynthetic origins and assignments of carbon 13 NMR peaks of brevetoxin B. Journal of the American Chemical Society. 108: 7855-6. PMID 22283310 DOI: 10.1021/Ja00284A072  0.414
1986 Lee MS, Repeta DJ, Nakanishi K, Zagorski MG. Biosynthetic origins and assignments of 13C NMR peaks of brevetoxin B Journal of the American Chemical Society. 108: 7855-7856.  0.332
1985 Zagorski MG, Allan DS, Salomon RG, Clennan EL, Heah PC, L'Esperance RP. Oxygen-17 nuclear magnetic resonance chemical shifts of dialkyl peroxides: Large conformational effects Journal of Organic Chemistry. 50: 4484-4490. DOI: 10.1002/Chin.198618055  0.5
1985 SALOMON RG, MILLER DB, ZAGORSKI MG, COUGHLIN DJ. ChemInform Abstract: PROSTAGLANDIN ENDOPEROXIDES. 14. SOLVENT-INDUCED FRAGMENTATION OF PROSTAGLANDIN ENDOPEROXIDES. NEW ALDEHYDE PRODUCTS FROM PGH2 AND A NOVEL INTRAMOLECULAR 1,2-HYDRIDE SHIFT DURING ENDOPEROXIDE FRAGMENTATION IN AQUEOUS SOLUTION Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198504083  0.491
1984 Salomon RG, Miller DB, Zagorski MG, Coughlin DJ. Solvent-induced fragmentation of prostaglandin endoperoxides. New aldehyde products from PGH2 and a novel intramolecular 1,2-hydride shift during endoperoxide fragmentation in aqueous solution Journal of the American Chemical Society. 106: 6049-6060. DOI: 10.1021/Ja00332A049  0.488
1984 Zagorski MG, Salomon RG. Base-catalyzed fragmentation of 2,3-dioxabicyclo[2.2.1]heptane, the bicyclic peroxide nucleus of prostaglandin endoperoxides: Large secondary deuterium kinetic isotope effects Journal of the American Chemical Society. 106: 1750-1759. DOI: 10.1002/Chin.198426098  0.484
1982 Salomon RG, Ghosh S, Zagorski MG, Reitz M. Copper (I) catalysis of olefin photoreactions. 10. Synthesis of multicyclic carbon networks by photobicyclization Journal of Organic Chemistry. 47: 829-836. DOI: 10.1021/Jo00344A016  0.542
1982 Salomon RG, Coughlin DJ, Ghosh S, Zagorski MG. Copper(I) catalysis of olefin photoreactions. 9. Photobicyclization of .alpha.-, .beta.-, and .gamma.-alkenylallyl alcohols Journal of the American Chemical Society. 104: 998-1007. DOI: 10.1021/Ja00368A014  0.589
1982 Zagorski MG, Salomon RG. Prostaglandin endoperoxides. 12. Carboxylate catalysis and the effects of proton donors on the decomposition of 2,3-dioxabicyclo[2.2.1]heptane Journal of the American Chemical Society. 104: 3498-3503. DOI: 10.1002/Chin.198239116  0.468
1982 Salomon RG, Salomon MF, Zagorski MG, Reuter JM, Coughlin DJ. Total synthesis refutes the postulated structure of leucogenenol Journal of the American Chemical Society. 104: 1008-1013. DOI: 10.1002/Chin.198223168  0.525
1982 SALOMON RG, COUGHLIN DJ, GHOSH S, ZAGORSKI MG. ChemInform Abstract: COPPER(I) CATALYSIS OF OLEFIN PHOTOREACTIONS. 9. PHOTOBICYCLIZATION OF α-, β-, AND Γ-ALKENYLALLYL ALCOHOLS Chemischer Informationsdienst. 13. DOI: 10.1002/Chin.198223129  0.557
1980 Zagorski MG, Salomon RG. Prostaglandin endoperoxides. 11. Mechanism of amine-catalyzed fragmentation of 2,3-dioxabicyclo[2.2.1]heptane [33] Journal of the American Chemical Society. 102: 2501-2503. DOI: 10.1021/Ja00527A081  0.476
1980 Zagorski MG, Salomon RG. Prostaglandin Endoperoxides. 11. Mechanism Of Amine-Catalyzed Fragmentation Of 2,3-Dioxabicyclo(2.2.1)Heptane Cheminform. 11. DOI: 10.1002/Chin.198028122  0.476
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