Michael G. Zagorski, Ph.D. - Publications

1983-1986 Chemistry Columbia University, New York, NY 
 1989-1992 Suntory Institute for Bioorganic Research 
 1992- Chemistry Case Western Reserve University, Cleveland Heights, OH, United States 
Protein misfolding, amyloid formation

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Hou L, Lee HG, Han F, Tedesco JM, Perry G, Smith MA, Zagorski MG. Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation. Journal of Alzheimer's Disease : Jad. 37: 9-18. PMID 23719512 DOI: 10.3233/Jad-122389  1
2012 Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki J, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M. Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. The Journal of Biological Chemistry. 287: 14631-43. PMID 22393064 DOI: 10.1074/Jbc.M111.325456  1
2009 Bhaskar K, Miller M, Chludzinski A, Herrup K, Zagorski M, Lamb BT. The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Molecular Neurodegeneration. 4: 14. PMID 19291319 DOI: 10.1186/1750-1326-4-14  1
2008 Friedland RP, Tedesco JM, Wilson AC, Atwood CS, Smith MA, Perry G, Zagorski MG. Antibodies to potato virus Y bind the amyloid beta peptide: immunohistochemical and NMR studies. The Journal of Biological Chemistry. 283: 22550-6. PMID 18505725 DOI: 10.1074/Jbc.M802088200  1
2008 Gustaw KA, Garrett MR, Lee HG, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP, Smith MA. Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis. Journal of Neurochemistry. 106: 1350-6. PMID 18485104 DOI: 10.1111/J.1471-4159.2008.05477.X  1
2006 Hou L, Zagorski MG. NMR reveals anomalous copper(II) binding to the amyloid Abeta peptide of Alzheimer's disease. Journal of the American Chemical Society. 128: 9260-1. PMID 16848423 DOI: 10.1021/Ja046032U  1
2006 Apetri MM, Maiti NC, Zagorski MG, Carey PR, Anderson VE. Secondary structure of alpha-synuclein oligomers: characterization by raman and atomic force microscopy. Journal of Molecular Biology. 355: 63-71. PMID 16303137 DOI: 10.1016/J.Jmb.2005.10.071  1
2004 Srinivasan R, Marchant RE, Zagorski MG. ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 11: 10-3. PMID 15185493 DOI: 10.1080/13506120410001667872  1
2004 Maiti NC, Apetri MM, Zagorski MG, Carey PR, Anderson VE. Raman spectroscopic characterization of secondary structure in natively unfolded proteins: alpha-synuclein. Journal of the American Chemical Society. 126: 2399-408. PMID 14982446 DOI: 10.1021/Ja0356176  1
2004 Hou L, Shao H, Zhang Y, Li H, Menon NK, Neuhaus EB, Brewer JM, Byeon IJ, Ray DG, Vitek MP, Iwashita T, Makula RA, Przybyla AB, Zagorski MG. Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. Journal of the American Chemical Society. 126: 1992-2005. PMID 14971932 DOI: 10.1021/Ja036813F  1
2004 Hou L, Zagorski MG. Sorting out the driving forces for parallel and antiparallel alignment in the abeta peptide fibril structure. Biophysical Journal. 86: 1-2. PMID 14695243 DOI: 10.1016/S0006-3495(04)74077-1  1
2003 Srinivasan R, Jones EM, Liu K, Ghiso J, Marchant RE, Zagorski MG. pH-dependent amyloid and protofibril formation by the ABri peptide of familial British dementia. Journal of Molecular Biology. 333: 1003-23. PMID 14583196 DOI: 10.1016/J.Jmb.2003.09.001  1
2002 Hou L, Kang I, Marchant RE, Zagorski MG. Methionine 35 oxidation reduces fibril assembly of the amyloid abeta-(1-42) peptide of Alzheimer's disease. The Journal of Biological Chemistry. 277: 40173-6. PMID 12198111 DOI: 10.1074/Jbc.C200338200  1
2002 Adams PD, Chen Y, Ma K, Zagorski MG, Sönnichsen FD, McLaughlin ML, Barkley MD. Intramolecular quenching of tryptophan fluorescence by the peptide bond in cyclic hexapeptides. Journal of the American Chemical Society. 124: 9278-86. PMID 12149035 DOI: 10.1021/Ja0167710  1
2001 Poeggeler B, Miravalle L, Zagorski MG, Wisniewski T, Chyan YJ, Zhang Y, Shao H, Bryant-Thomas T, Vidal R, Frangione B, Ghiso J, Pappolla MA. Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide. Biochemistry. 40: 14995-5001. PMID 11732920 DOI: 10.1021/Bi0114269  1
2001 Zeng H, Zhang Y, Peng L, Shao H, Menon NK, Yang J, Salomon AR, Freidland RP, Zagorski MG. Nicotine and amyloid formation. Biological Psychiatry. 49: 248-57. PMID 11230876 DOI: 10.1016/S0006-3223(00)01111-2  1
2000 Zhang Y, Swietnicki W, Zagorski MG, Surewicz WK, Sönnichsen FD. Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases. The Journal of Biological Chemistry. 275: 33650-4. PMID 10954699 DOI: 10.1074/Jbc.C000483200  1
1999 Zagorski MG, Yang J, Shao H, Ma K, Zeng H, Hong A. Methodological and chemical factors affecting amyloid beta peptide amyloidogenicity. Methods in Enzymology. 309: 189-204. PMID 10507025 DOI: 10.1016/S0076-6879(99)09015-1  1
1999 Shao H, Jao S, Ma K, Zagorski MG. Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease. Journal of Molecular Biology. 285: 755-73. PMID 9878442 DOI: 10.1006/Jmbi.1998.2348  1
1999 Ma K, Clancy EL, Zhang Y, Ray DG, Wollenberg K, Zagorski MG. Residue-specific pK(a) measurements of the β-peptide and mechanism of pH-induced amyloid formation Journal of the American Chemical Society. 121: 8698-8706. DOI: 10.1021/Ja990864O  1
1998 Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. The Journal of Biological Chemistry. 273: 7185-8. PMID 9516407 DOI: 10.1074/Jbc.273.13.7185  1
1998 Marcinowski KJ, Shao H, Clancy EL, Zagorski MG. Solution structure model of residues 1-28 of the amyloid β-peptide when bound to micelles Journal of the American Chemical Society. 120: 11082-11091. DOI: 10.1021/Ja9738687  1
1997 Sayre LM, Zagorski MG, Surewicz WK, Krafft GA, Perry G. Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal. Chemical Research in Toxicology. 10: 518-26. PMID 9168248 DOI: 10.1021/Tx970009N  1
1997 Jao SC, Ma K, Talafous J, Orlando R, Zagorski MG. Trifluoroacetic acid pretreatment reproducibly disaggregates the amyloid β-peptide Amyloid. 4: 240-252. DOI: 10.3109/13506129709003835  1
1997 Adams PD, Ma K, Zagorski MG, Barkley MD. NMR and fluorescence spectroscopy studies of a somatostatin analog in aqueous solution Faseb Journal. 11: A1324.  1
1996 Salomon AR, Marcinowski KJ, Friedland RP, Zagorski MG. Nicotine inhibits amyloid formation by the beta-peptide. Biochemistry. 35: 13568-78. PMID 8885836 DOI: 10.1021/Bi9617264  1
1994 Schwarzman AL, Gregori L, Vitek MP, Lyubski S, Strittmatter WJ, Enghilde JJ, Bhasin R, Silverman J, Weisgraber KH, Coyle PK. Transthyretin sequesters amyloid beta protein and prevents amyloid formation. Proceedings of the National Academy of Sciences of the United States of America. 91: 8368-72. PMID 8078889 DOI: 10.1073/Pnas.91.18.8368  1
1994 Talafous J, Marcinowski KJ, Klopman G, Zagorski MG. Solution structure of residues 1-28 of the amyloid beta-peptide. Biochemistry. 33: 7788-96. PMID 7516706 DOI: 10.1021/Bi00191A006  1
1992 Barrow CJ, Yasuda A, Kenny PT, Zagorski MG. Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra. Journal of Molecular Biology. 225: 1075-93. PMID 1613791 DOI: 10.1016/0022-2836(92)90106-T  1
1992 Zagorski MG, Barrow CJ. NMR studies of amyloid beta-peptides: proton assignments, secondary structure, and mechanism of an alpha-helix----beta-sheet conversion for a homologous, 28-residue, N-terminal fragment. Biochemistry. 31: 5621-31. PMID 1610809 DOI: 10.1021/Bi00139A028  1
1992 Orlando R, Kenny PT, Zagorski MG. Covalent modification of Alzheimer's amyloid beta-peptide in formic acid solutions. Biochemical and Biophysical Research Communications. 184: 686-91. PMID 1575742 DOI: 10.1016/0006-291X(92)90644-Z  1
1992 Zagorski MG. Improved lineshapes and water suppression in 2D NMR spectra using composite 90° pulses to compensate RF imperfections Journal of Magnetic Resonance (1969). 99: 403-407. DOI: 10.1016/0022-2364(92)90194-C  1
1991 Zagorski MG, Norman DG, Barrow CJ, Iwashita T, Tachibana K, Patel DJ. Solution structure of pardaxin P-2. Biochemistry. 30: 8009-17. PMID 1868074 DOI: 10.1021/Bi00246A019  1
1991 Barrow CJ, Zagorski MG. Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition. Science (New York, N.Y.). 253: 179-82. PMID 1853202 DOI: 10.1126/Science.1853202  1
1991 Nakayama T, Amachi T, Murao S, Sakai T, Shin T, Kenny PTM, Iwashita T, Zagorski M, Komura H, Nomoto K. Structure of trehalostatin: a potent and specific inhibitor of trehalase Journal of the Chemical Society, Chemical Communications. 919-921. DOI: 10.1039/C39910000919  0.56
1991 Zagorski MG. Further reduction of the water "Hump" using the GROPE-16 sequence Journal of Magnetic Resonance (1969). 91: 141-147. DOI: 10.1016/0022-2364(91)90417-R  1
1990 Zagorski MG. How to obtain accurate CAMELSPIN or ROESY spectra with identical low-power pulses for both the preparation and the mixing intervals Journal of Magnetic Resonance (1969). 89: 608-614. DOI: 10.1016/0022-2364(90)90346-B  1
1990 Zagorski MG. Improved frequency selectivity for presaturation of H2O in 2D NMR spectra of proteins Journal of Magnetic Resonance (1969). 86: 400-405. DOI: 10.1016/0022-2364(90)90272-B  1
1989 Kalnik MW, Norman DG, Zagorski MG, Swann PF, Patel DJ. Conformational transitions in cytidine bulge-containing deoxytridecanucleotide duplexes: extra cytidine equilibrates between looped out (low temperature) and stacked (elevated temperature) conformations in solution. Biochemistry. 28: 294-303. PMID 2706253 DOI: 10.1021/Bi00427A040  1
1989 Zagorski MG, Bowie JU, Vershon AK, Sauer RT, Patel DJ. NMR studies of Arc repressor mutants: proton assignments, secondary structure, and long-range contacts for the thermostable proline-8----leucine variant of Arc. Biochemistry. 28: 9813-25. PMID 2611267 DOI: 10.1021/Bi00451A041  1
1989 Lee MS, Qin GW, Nakanishi K, Zagorski MG. Biosynthetic studies of brevetoxins, potent neurotoxins produced by the dinoflagellate Gymnodinium breve Journal of the American Chemical Society. 111: 6234-6241. DOI: 10.1021/Ja00198A039  1
1989 Zagorski MG, Norman DG. Assignments of 31P and 1H resonances in oligonucleotides by two-dimensional hartmann-hahn spectroscopy Journal of Magnetic Resonance (1969). 83: 167-172. DOI: 10.1016/0022-2364(89)90301-6  1
1988 Zagorski MG, Nakanishi K, Qin GW, Lee MS. Assignment of carbon-13 NMR peaks of brevetoxin A: application of two-dimensional Hartmann-Hahn spectroscopy Journal of Organic Chemistry. 53: 4156-4158. DOI: 10.1021/Jo00252A068  0.72
1988 Zagorski MG, Nakanishi K, Qin GW, Lee MS. Assignment of 13C NMR peaks of brevetoxin A: Application of two-dimensional hartmann-hahn spectroscopy Journal of Organic Chemistry. 53: 4156-4158.  1
1988 Marston A, Zagorski MG, Hostettmann K. Antifungal polyphenols from Cordia goetzei Gurke Helvetica Chimica Acta. 71: 1210-1219.  0.56
1987 Turner CJ, Tempesta MS, Taylor RB, Zagorski MG, Termini JS, Schroeder DR, Nakanishi K. An NMR spectroscopic study of azadirachtin and its trimethyl ether Tetrahedron. 43: 2789-2803. DOI: 10.1016/S0040-4020(01)86885-X  1
1987 Pawlak J, Tempesta MS, Golik J, Zagorski MG, Lee MS, Nakanishi K, Iwashita T, Gross ML, Tomer KB. Structure of brevetoxin A as constructed from NMR and MS data Journal of the American Chemical Society. 109: 1144-1150.  1
1986 Lee MS, Repeta DJ, Nakanishi K, Zagorski MG. Biosynthetic origins and assignments of carbon 13 NMR peaks of brevetoxin B. Journal of the American Chemical Society. 108: 7855-6. PMID 22283310 DOI: 10.1021/Ja00284A072  0.72
1986 Lee MS, Repeta DJ, Nakanishi K, Zagorski MG. Biosynthetic origins and assignments of 13C NMR peaks of brevetoxin B Journal of the American Chemical Society. 108: 7855-7856.  1
1985 Zagorski MG, Allan DS, Salomon RG, Clennan EL, Heah PC, L'Esperance RP. Oxygen-17 nuclear magnetic resonance chemical shifts of dialkyl peroxides: Large conformational effects Journal of Organic Chemistry. 50: 4484-4490. DOI: 10.1002/Chin.198618055  1
1984 Salomon RG, Miller DB, Zagorski MG, Coughlin DJ. Solvent-induced fragmentation of prostaglandin endoperoxides. New aldehyde products from PGH2 and a novel intramolecular 1,2-hydride shift during endoperoxide fragmentation in aqueous solution Journal of the American Chemical Society. 106: 6049-6060. DOI: 10.1021/Ja00332A049  1
1984 Zagorski MG, Salomon RG. Base-catalyzed fragmentation of 2,3-dioxabicyclo[2.2.1]heptane, the bicyclic peroxide nucleus of prostaglandin endoperoxides: Large secondary deuterium kinetic isotope effects Journal of the American Chemical Society. 106: 1750-1759. DOI: 10.1002/Chin.198426098  1
1982 Salomon RG, Ghosh S, Zagorski MG, Reitz M. Copper (I) catalysis of olefin photoreactions. 10. Synthesis of multicyclic carbon networks by photobicyclization Journal of Organic Chemistry. 47: 829-836. DOI: 10.1021/Jo00344A016  1
1982 Zagorski MG, Salomon RG. Prostaglandin endoperoxides. 12. Carboxylate catalysis and the effects of proton donors on the decomposition of 2,3-dioxabicyclo[2.2.1]heptane Journal of the American Chemical Society. 104: 3498-3503. DOI: 10.1002/Chin.198239116  1
1982 Salomon RG, Salomon MF, Zagorski MG, Reuter JM, Coughlin DJ. Total synthesis refutes the postulated structure of leucogenenol Journal of the American Chemical Society. 104: 1008-1013. DOI: 10.1002/Chin.198223168  1
1980 Zagorski MG, Salomon RG. Prostaglandin endoperoxides. 11. Mechanism of amine-catalyzed fragmentation of 2,3-dioxabicyclo[2.2.1]heptane [33] Journal of the American Chemical Society. 102: 2501-2503. DOI: 10.1021/Ja00527A081  1
1980 Zagorski MG, Salomon RG. Prostaglandin Endoperoxides. 11. Mechanism Of Amine-Catalyzed Fragmentation Of 2,3-Dioxabicyclo(2.2.1)Heptane Cheminform. 11. DOI: 10.1002/Chin.198028122  1
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