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Kyle R. Spinler, Ph.D. - Publications

Affiliations: 
Chemical and Biomolecular Engineering University of Pennsylvania, Philadelphia, PA, United States 
Area:
cell biophysics and polymer engineering
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Alvey CM, Spinler KR, Irianto J, Pfeifer CR, Hayes B, Xia Y, Cho S, Dingal PCPD, Hsu J, Smith L, Tewari M, Discher DE. SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors. Current Biology : Cb. PMID 28669759 DOI: 10.1016/J.Cub.2017.06.005  0.708
2017 Ivanovska IL, Swift J, Spinler K, Dingal D, Cho S, Discher DE. Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation. Molecular Biology of the Cell. PMID 28566555 DOI: 10.1091/Mbc.E17-01-0010  0.768
2016 Nair PR, Karthick SA, Spinler KR, Vakili MR, Lavasanifar A, Discher DE. Filomicelles from aromatic diblock copolymers increase paclitaxel-induced tumor cell death and aneuploidy compared with aliphatic copolymers. Nanomedicine (London, England). PMID 27177319 DOI: 10.2217/Nnm-2016-0007  0.755
2016 Alvey C, Spinler K, Tewari M, Discher D. 511. Engineered Donor Marrow Macrophages Phagocytose Cancer Cells and Aggressively Shrink Solid Tumor Xenografts Compared to Tumor Associated Macrophages Molecular Therapy. 24: S204. DOI: 10.1016/S1525-0016(16)33320-2  0.776
2016 Ivanovska IL, Swift J, Spinler K, Dingal D, Discher DE. Matrix and Soluble Factor Pathways to Lineage Specification Biophysical Journal. 110: 95a. DOI: 10.1016/J.Bpj.2015.11.570  0.604
2016 Nair PR, Spinler KR, Vakili MR, Lavasanifar A, Discher DE. Filovirus Mimics Deliver Effectively Biophysical Journal. 110: 504a. DOI: 10.1016/J.Bpj.2015.11.2694  0.775
2015 Sosale NG, Spinler KR, Alvey C, Discher DE. Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties. Current Opinion in Immunology. 35: 107-112. PMID 26172292 DOI: 10.1016/J.Coi.2015.06.013  0.724
2015 Spinler KR, Shin JW, Lambert MP, Discher DE. Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia. Blood. 125: 525-33. PMID 25395423 DOI: 10.1182/Blood-2014-05-576462  0.614
2015 Alvey CM, Spinler K, Tewari M, Discher D. Engineered Donor Marrow Macrophages Phagocytose Cancer Cells and Aggressively Shrink Solid Tumor Xenografts Compared to Tumor Associated Macrophages Blood. 126: 2214-2214. DOI: 10.1016/S1525-0016(16)33320-2  0.782
2015 Ivanovska IL, Swift J, Spinler K, Dingal PDP, Discher DE. Cross-Linked Matrix Rigidity and Soluble Factors Induce Differentiation via Distinct but Overlapping Pathways Biophysical Journal. 108: 560a-561a. DOI: 10.1016/J.Bpj.2014.11.3072  0.59
2014 Buxboim A, Swift J, Irianto J, Spinler KR, Dingal PC, Athirasala A, Kao YR, Cho S, Harada T, Shin JW, Discher DE. Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin. Current Biology : Cb. 24: 1909-17. PMID 25127216 DOI: 10.1016/J.Cub.2014.07.001  0.761
2014 Harada T, Swift J, Irianto J, Shin JW, Spinler KR, Athirasala A, Diegmiller R, Dingal PC, Ivanovska IL, Discher DE. Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. The Journal of Cell Biology. 204: 669-82. PMID 24567359 DOI: 10.1083/Jcb.201308029  0.721
2014 Shin JW, Buxboim A, Spinler KR, Swift J, Christian DA, Hunter CA, Léon C, Gachet C, Dingal PC, Ivanovska IL, Rehfeldt F, Chasis JA, Discher DE. Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell. 14: 81-93. PMID 24268694 DOI: 10.1016/J.Stem.2013.10.009  0.759
2014 Harada T, Swift J, Irianto J, Shin JW, Spinler KR, Athirasala A, Diegmiller R, Dingal PCDP, Ivanovska IL, Discher DE. Nuclear lamin stiffness is a barrier to 3D-migration, but softness can limit survival Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972810  0.628
2014 Discher DE, Swift J, Spinler K, Shin J. Lamins Regulate Cell Trafficking and Lineage Maturation of Hematopoietic Cells Biophysical Journal. 106: 571a. DOI: 10.1016/J.Bpj.2013.11.3169  0.675
2013 Shin JW, Spinler KR, Swift J, Chasis JA, Mohandas N, Discher DE. Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 18892-7. PMID 24191023 DOI: 10.1073/Pnas.1304996110  0.675
2013 Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PC, Pinter J, Pajerowski JD, Spinler KR, Shin JW, Tewari M, Rehfeldt F, Speicher DW, Discher DE. Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science (New York, N.Y.). 341: 1240104. PMID 23990565 DOI: 10.1126/Science.1240104  0.74
2013 Shin JW, Swift J, Ivanovska I, Spinler KR, Buxboim A, Discher DE. Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation; Research in Biological Diversity. 86: 77-86. PMID 23790394 DOI: 10.1016/J.Diff.2013.05.001  0.662
2013 Spinler K, Tian A, Christian DA, Pantano DA, Baumgart T, Discher DE. Dynamic domains in polymersomes: mixtures of polyanionic and neutral diblocks respond more rapidly to changes in calcium than to pH. Langmuir : the Acs Journal of Surfaces and Colloids. 29: 7499-508. PMID 23327600 DOI: 10.1021/La304602E  0.637
2013 Spinler KR, Shin J, Discher DE. Platelet-Like-Particles Sheared From Myosin-II-Inhibited Megakaryocytes Highlights The Elevated Thrombocrit Of May-Hegglin Anomaly Blood. 122: 2426-2426. DOI: 10.1182/Blood.V122.21.2426.2426  0.618
2013 Shin J, Spinler KR, Swift J, Discher DE. Hierarchical Determination of Nuclear Deformability by Lamin Isoforms during Adult Hematopoiesis: Implications in Blood Cell Trafficking Biophysical Journal. 104: 150a-151a. DOI: 10.1016/j.bpj.2012.11.854  0.446
2013 Spinler K, Shin J, Discher DE. Shear-Optimized Platelet-Like-Particles from High Ploidy MKS: From Segregation to Composition and Activation Biophysical Journal. 104: 142a. DOI: 10.1016/j.bpj.2012.11.806  0.388
2012 Shin J, Spinler KR, Swift J, Discher DE. Hierarchical Determination of Nuclear Deformability by Lamin Isoforms During Adult Hematopoiesis: Implications in Blood Cell Trafficking Blood. 120: 1200-1200. DOI: 10.1182/Blood.V120.21.1200.1200  0.661
2012 Spinler K, Shin JW, Discher DE. Platelet generation under shear force modulated by site-specific phosphorylation of myosin-IIA heavy chain 2012 38th Annual Northeast Bioengineering Conference, Nebec 2012. 217-218. DOI: 10.1182/Blood.V118.21.3262.3262  0.626
2012 Spinler KR, Shin J, Discher DE. Shear-Optimized Platelet-Like-Particles From High Ploidy Mks: From Segregation to Composition and Activation Blood. 120: 3456-3456. DOI: 10.1016/J.Bpj.2012.11.806  0.643
2011 Shin JW, Swift J, Spinler KR, Discher DE. Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proceedings of the National Academy of Sciences of the United States of America. 108: 11458-63. PMID 21709232 DOI: 10.1073/Pnas.1017474108  0.66
2011 Shin J, Spinler KR, Swift J, Discher DE. Differentiation of Hematopoietic Stem Cell Modulated by Actomyosin Forces Biophysical Journal. 100: 442a-443a. DOI: 10.1016/J.Bpj.2010.12.2606  0.686
2010 Shin J, Spinler KR, Swift J, Discher DE. Myosin-II Plays Central Roles In Cell Life and Death Decisions During Adult Hematopoiesis. Blood. 116: 1595-1595. DOI: 10.1182/Blood.V116.21.1595.1595  0.682
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