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Jason C. Pickens, Ph.D. - Publications

Affiliations: 
2003 University of Washington, Seattle, Seattle, WA 
Area:
protein crystallography for structure-based design of drugs for tropical diseases
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10 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2007 Lu RJ, Tucker JA, Zinevitch T, Kirichenko O, Konoplev V, Kuznetsova S, Sviridov S, Pickens J, Tandel S, Brahmachary E, Yang Y, Wang J, Freel S, Fisher S, Sullivan A, et al. Design and synthesis of human immunodeficiency virus entry inhibitors: sulfonamide as an isostere for the alpha-ketoamide group. Journal of Medicinal Chemistry. 50: 6535-44. PMID 18052117 DOI: 10.1021/Jm070650E  0.334
2004 Fan E, O'Neal CJ, Mitchell DD, Robien MA, Zhang Z, Pickens JC, Tan XJ, Korotkov K, Roach C, Krumm B, Verlinde CL, Merritt EA, Hol WG. Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin. International Journal of Medical Microbiology : Ijmm. 294: 217-23. PMID 15532979 DOI: 10.1016/J.Ijmm.2004.07.002  0.56
2004 Pickens JC, Mitchell DD, Liu J, Tan X, Zhang Z, Verlinde CL, Hol WG, Fan E. Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chemistry & Biology. 11: 1205-15. PMID 15380181 DOI: 10.1016/J.Chembiol.2004.06.008  0.682
2004 Zhang Z, Pickens JC, Hol WG, Fan E. Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design. Organic Letters. 6: 1377-80. PMID 15101746 DOI: 10.1021/Ol049835V  0.554
2004 Mitchell DD, Pickens JC, Korotkov K, Fan E, Hol WG. 3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies. Bioorganic & Medicinal Chemistry. 12: 907-20. PMID 14980603 DOI: 10.1016/J.Bmc.2003.12.019  0.681
2002 Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WG, Fan E. Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. Journal of the American Chemical Society. 124: 8818-24. PMID 12137534 DOI: 10.1021/Ja0202560  0.701
2002 Pickens JC, Merritt EA, Ahn M, Verlinde CL, Hol WG, Fan E. Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Chemistry & Biology. 9: 215-24. PMID 11880036 DOI: 10.1016/S1074-5521(02)00097-2  0.733
2002 Hol WGJ, Fan E, Minke WE, Hovey B, Zhang Z, Pickens J, Van den Akker F, O'Neal C, Ahn M, Korotkov K, Verlinde CLMJ, Merritt EA. Inhibitor design and the cholera toxin family - from water puzzles to 10 kD spiders Acta Crystallographica Section a Foundations of Crystallography. 58: c1-c1. DOI: 10.1107/S0108767302085148  0.605
2001 Fan E, Merritt EA, Zhang Z, Pickens JC, Roach C, Ahn M, Hol WG. Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallographica. Section D, Biological Crystallography. 57: 201-12. PMID 11173465 DOI: 10.1107/S0907444900016814  0.685
2000 Minke WE, Pickens J, Merritt EA, Fan E, Verlinde CL, Hol WG. Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes. Acta Crystallographica. Section D, Biological Crystallography. 56: 795-804. PMID 10930826 DOI: 10.1107/S090744490000514X  0.69
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