| Year |
Citation |
Score |
| 2016 |
Huang W, Zhang Z, Barros-Álvarez X, Koh CY, Ranade RM, Gillespie JR, Creason SA, Shibata S, Verlinde CL, Hol WG, Buckner FS, Fan E. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. European Journal of Medicinal Chemistry. 124: 1081-1092. PMID 27788467 DOI: 10.1016/J.Ejmech.2016.10.024 |
0.786 |
|
| 2016 |
Zhang Z, Koh CY, Ranade RM, Shibata S, Gillespie JR, Hulverson MA, Huang W, Nguyen J, Pendem N, Gelb MH, Verlinde CL, Hol WG, Buckner FS, Fan E. 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infectious Diseases. 2: 399-404. PMID 27627628 DOI: 10.1021/Acsinfecdis.6B00036 |
0.602 |
|
| 2015 |
Ranade RM, Zhang Z, Gillespie JR, Shibata S, Verlinde CL, Hol WG, Fan E, Buckner FS. Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites. Antimicrobial Agents and Chemotherapy. 59: 7128-31. PMID 26324270 DOI: 10.1128/Aac.01573-15 |
0.578 |
|
| 2015 |
Koh CY, Siddaramaiah LK, Ranade RM, Nguyen J, Jian T, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallographica. Section D, Biological Crystallography. 71: 1684-98. PMID 26249349 DOI: 10.1107/S1399004715007683 |
0.651 |
|
| 2015 |
Pedró-Rosa L, Buckner FS, Ranade RM, Eberhart C, Madoux F, Gillespie JR, Koh CY, Brown S, Lohse J, Verlinde CL, Fan E, Bannister T, Scampavia L, Hol WG, Spicer T, et al. Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. Journal of Biomolecular Screening. 20: 122-30. PMID 25163684 DOI: 10.1177/1087057114548832 |
0.534 |
|
| 2014 |
Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness. Plos Neglected Tropical Diseases. 8: e2775. PMID 24743796 DOI: 10.1371/Journal.Pntd.0002775 |
0.691 |
|
| 2014 |
Vidadala RS, Ojo KK, Johnson SM, Zhang Z, Leonard SE, Mitra A, Choi R, Reid MC, Keyloun KR, Fox AM, Kennedy M, Silver-Brace T, Hume JC, Kappe S, Verlinde CL, et al. Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. European Journal of Medicinal Chemistry. 74: 562-73. PMID 24531197 DOI: 10.1016/J.Ejmech.2013.12.048 |
0.401 |
|
| 2014 |
Zhang Z, Ojo KK, Vidadala R, Huang W, Geiger JA, Scheele S, Choi R, Reid MC, Keyloun KR, Rivas K, Siddaramaiah LK, Comess KM, Robinson KP, Merta PJ, Kifle L, ... ... Verlinde CL, et al. Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. Acs Medicinal Chemistry Letters. 5: 40-44. PMID 24494061 DOI: 10.1021/Ml400315S |
0.57 |
|
| 2014 |
Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AM, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, ... Verlinde CL, et al. A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation. The Journal of Infectious Diseases. 209: 275-84. PMID 24123773 DOI: 10.1093/Infdis/Jit522 |
0.373 |
|
| 2014 |
Koh CY, Nguyen J, Shibata S, Zhang Z, Ranade R, Gillespie JR, Hodder P, Pedro-Rosa L, Bannister T, Buckner F, Verlinde C, Fan E, Hol W. Structure-based drug design against Trypanosoma brucei methionyl-tRNA synthetase Acta Crystallographica Section a Foundations and Advances. 70: C708-C708. DOI: 10.1107/S2053273314092912 |
0.613 |
|
| 2013 |
Suryadevara PK, Racherla KK, Olepu S, Norcross NR, Tatipaka HB, Arif JA, Planer JD, Lepesheva GI, Verlinde CL, Buckner FS, Gelb MH. Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents. Bioorganic & Medicinal Chemistry Letters. 23: 6492-9. PMID 24120539 DOI: 10.1016/J.Bmcl.2013.08.015 |
0.372 |
|
| 2013 |
Khamrui S, Turley S, Pardon E, Steyaert J, Fan E, Verlinde CL, Bergman LW, Hol WG. The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody. Molecular and Biochemical Parasitology. 190: 87-91. PMID 23831371 DOI: 10.1016/J.Molbiopara.2013.06.003 |
0.627 |
|
| 2013 |
Koh CY, Kim JE, Napoli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Hol WG. Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Molecular and Biochemical Parasitology. 189: 26-32. PMID 23665145 DOI: 10.1016/J.Molbiopara.2013.04.007 |
0.619 |
|
| 2013 |
Ranade RM, Gillespie JR, Shibata S, Verlinde CL, Fan E, Hol WG, Buckner FS. Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target. Antimicrobial Agents and Chemotherapy. 57: 3021-8. PMID 23587950 DOI: 10.1128/Aac.02578-12 |
0.535 |
|
| 2012 |
Larson ET, Kim JE, Napuli AJ, Verlinde CL, Fan E, Zucker FH, Van Voorhis WC, Buckner FS, Hol WG, Merritt EA. Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallographica. Section D, Biological Crystallography. 68: 1194-200. PMID 22948920 DOI: 10.1107/S0907444912024699 |
0.6 |
|
| 2012 |
Koh CY, Kim JE, Shibata S, Ranade RM, Yu M, Liu J, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure (London, England : 1993). 20: 1681-91. PMID 22902861 DOI: 10.1016/J.Str.2012.07.011 |
0.659 |
|
| 2012 |
Zhang Z, Ojo KK, Johnson SM, Larson ET, He P, Geiger JA, Castellanos-Gonzalez A, White AC, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E. Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1. Bioorganic & Medicinal Chemistry Letters. 22: 5264-7. PMID 22795629 DOI: 10.1016/J.Bmcl.2012.06.050 |
0.381 |
|
| 2012 |
Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH. Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib. Antimicrobial Agents and Chemotherapy. 56: 4914-21. PMID 22777048 DOI: 10.1128/Aac.06244-11 |
0.399 |
|
| 2012 |
Shibata S, Gillespie JR, Ranade RM, Koh CY, Kim JE, Laydbak JU, Zucker FH, Hol WG, Verlinde CL, Buckner FS, Fan E. Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. Journal of Medicinal Chemistry. 55: 6342-51. PMID 22720744 DOI: 10.1021/Jm300303E |
0.594 |
|
| 2012 |
Ojo KK, Pfander C, Mueller NR, Burstroem C, Larson ET, Bryan CM, Fox AM, Reid MC, Johnson SM, Murphy RC, Kennedy M, Mann H, Leibly DJ, Hewitt SN, Verlinde CL, et al. Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors. The Journal of Clinical Investigation. 122: 2301-5. PMID 22565309 DOI: 10.1172/Jci61822 |
0.333 |
|
| 2012 |
Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AM, Reid MC, Dale EJ, Perera BG, Kim J, Hewitt SN, Hol WG, Verlinde CL, et al. Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. Journal of Medicinal Chemistry. 55: 2803-10. PMID 22369268 DOI: 10.1021/Jm201725V |
0.587 |
|
| 2011 |
Shibata S, Zhang Z, Korotkov KV, Delarosa J, Napuli A, Kelley AM, Mueller N, Ross J, Zucker FH, Buckner FS, Merritt EA, Verlinde CL, Van Voorhis WC, Hol WG, Fan E. Screening a fragment cocktail library using ultrafiltration. Analytical and Bioanalytical Chemistry. 401: 1585-91. PMID 21750879 DOI: 10.1007/S00216-011-5225-7 |
0.594 |
|
| 2011 |
Larson ET, Kim JE, Castaneda LJ, Napuli AJ, Zhang Z, Fan E, Zucker FH, Verlinde CL, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA. The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. Journal of Molecular Biology. 409: 159-76. PMID 21420975 DOI: 10.1016/J.Jmb.2011.03.026 |
0.601 |
|
| 2011 |
Shibata S, Gillespie JR, Kelley AM, Napuli AJ, Zhang Z, Kovzun KV, Pefley RM, Lam J, Zucker FH, Van Voorhis WC, Merritt EA, Hol WG, Verlinde CL, Fan E, Buckner FS. Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrobial Agents and Chemotherapy. 55: 1982-9. PMID 21282428 DOI: 10.1128/Aac.01796-10 |
0.621 |
|
| 2011 |
Merritt EA, Arakaki TL, Gillespie R, Napuli AJ, Kim JE, Buckner FS, Van Voorhis WC, Verlinde CL, Fan E, Zucker F, Hol WG. Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Molecular and Biochemical Parasitology. 177: 20-8. PMID 21255615 DOI: 10.1016/J.Molbiopara.2011.01.003 |
0.572 |
|
| 2011 |
Ojo KK, Arakaki TL, Napuli AJ, Inampudi KK, Keyloun KR, Zhang L, Hol WG, Verlinde CL, Merritt EA, Van Voorhis WC. Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3. Molecular and Biochemical Parasitology. 176: 98-108. PMID 21195115 DOI: 10.1016/J.Molbiopara.2010.12.009 |
0.611 |
|
| 2011 |
Larson ET, Kim JE, Zucker FH, Kelley A, Mueller N, Napuli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG. Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie. 93: 570-82. PMID 21144880 DOI: 10.1016/J.Biochi.2010.11.015 |
0.619 |
|
| 2010 |
Murphy RC, Ojo KK, Larson ET, Castellanos-Gonzalez A, Perera BG, Keyloun KR, Kim JE, Bhandari JG, Muller NR, Verlinde CL, White AC, Merritt EA, Van Voorhis WC, Maly DJ. Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii. Acs Medicinal Chemistry Letters. 1: 331-335. PMID 21116453 DOI: 10.1021/Ml100096T |
0.328 |
|
| 2010 |
Arakaki TL, Carter M, Napuli AJ, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA. The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. Journal of Structural Biology. 171: 238-43. PMID 20438846 DOI: 10.1016/J.Jsb.2010.04.010 |
0.585 |
|
| 2010 |
Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, et al. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nature Structural & Molecular Biology. 17: 602-7. PMID 20436472 DOI: 10.1038/Nsmb.1818 |
0.6 |
|
| 2010 |
Kraus JM, Tatipaka HB, McGuffin SA, Chennamaneni NK, Karimi M, Arif J, Verlinde CL, Buckner FS, Gelb MH. Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. Journal of Medicinal Chemistry. 53: 3887-98. PMID 20429511 DOI: 10.1021/Jm9013136 |
0.42 |
|
| 2010 |
Zucker FH, Stewart C, dela Rosa J, Kim J, Zhang L, Xiao L, Ross J, Napuli AJ, Mueller N, Castaneda LJ, Nakazawa Hewitt SR, Arakaki TL, Larson ET, Subramanian E, Verlinde CL, et al. Prediction of protein crystallization outcome using a hybrid method. Journal of Structural Biology. 171: 64-73. PMID 20347992 DOI: 10.1016/J.Jsb.2010.03.016 |
0.554 |
|
| 2010 |
Galland N, de Walque S, Voncken FG, Verlinde CL, Michels PA. An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes. Molecular and Biochemical Parasitology. 171: 45-9. PMID 20138091 DOI: 10.1016/J.Molbiopara.2010.01.002 |
0.339 |
|
| 2010 |
Merritt EA, Arakaki TL, Gillespie JR, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CL, Fan E, Zucker F, Buckner FS, van Voorhis WC, Hol WG. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. Journal of Molecular Biology. 397: 481-94. PMID 20132829 DOI: 10.1016/J.Jmb.2010.01.051 |
0.626 |
|
| 2010 |
Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, et al. The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. Journal of Molecular Biology. 396: 1244-59. PMID 20070944 DOI: 10.1016/J.Jmb.2010.01.013 |
0.552 |
|
| 2010 |
Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG. Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Molecular and Biochemical Parasitology. 169: 95-100. PMID 19874856 DOI: 10.1016/J.Molbiopara.2009.10.005 |
0.588 |
|
| 2009 |
Verlinde CL, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki TL, Bosch J, Caruthers JM, Larson ET, Letrong I, Napuli A, et al. Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium. Current Topics in Medicinal Chemistry. 9: 1678-87. PMID 19929835 DOI: 10.2174/156802609790102383 |
0.571 |
|
| 2009 |
Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, et al. Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. Journal of Biomolecular Screening. 14: 700-7. PMID 19470714 DOI: 10.1177/1087057109335749 |
0.551 |
|
| 2009 |
Suryadevara PK, Olepu S, Lockman JW, Ohkanda J, Karimi M, Verlinde CL, Kraus JM, Schoepe J, Van Voorhis WC, Hamilton AD, Buckner FS, Gelb MH. Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. Journal of Medicinal Chemistry. 52: 3703-15. PMID 19463001 DOI: 10.1021/Jm900030H |
0.396 |
|
| 2009 |
Kraus JM, Verlinde CL, Karimi M, Lepesheva GI, Gelb MH, Buckner FS. Rational modification of a candidate cancer drug for use against Chagas disease. Journal of Medicinal Chemistry. 52: 1639-47. PMID 19239254 DOI: 10.1021/Jm801313T |
0.366 |
|
| 2008 |
Kline T, Jackson SR, Deng W, Verlinde CL, Miller SI. Design and synthesis of bis-carbamate analogs of cyclic bis-(3'-5')-diguanylic acid (c-di-GMP) and the acyclic dimer PGPG. Nucleosides, Nucleotides & Nucleic Acids. 27: 1282-300. PMID 19003573 DOI: 10.1080/15257770802554150 |
0.334 |
|
| 2008 |
Deng W, Verlinde CL. Evaluation of different virtual screening programs for docking in a charged binding pocket. Journal of Chemical Information and Modeling. 48: 2010-20. PMID 18821750 DOI: 10.1021/Ci800154W |
0.366 |
|
| 2008 |
Oslund RC, Cermak N, Verlinde CL, Gelb MH. Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA. Bioorganic & Medicinal Chemistry Letters. 18: 5415-9. PMID 18818074 DOI: 10.1016/J.Bmcl.2008.09.041 |
0.364 |
|
| 2008 |
Ojo KK, Gillespie JR, Riechers AJ, Napuli AJ, Verlinde CL, Buckner FS, Gelb MH, Domostoj MM, Wells SJ, Scheer A, Wells TN, Van Voorhis WC. Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. Antimicrobial Agents and Chemotherapy. 52: 3710-7. PMID 18644955 DOI: 10.1128/Aac.00364-08 |
0.365 |
|
| 2008 |
Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA. Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. Journal of Molecular Biology. 381: 975-88. PMID 18602399 DOI: 10.1016/J.Jmb.2008.06.048 |
0.618 |
|
| 2008 |
Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, et al. Structural genomics of pathogenic protozoa: an overview. Methods in Molecular Biology (Clifton, N.J.). 426: 497-513. PMID 18542886 DOI: 10.1007/978-1-60327-058-8_33 |
0.562 |
|
| 2008 |
Liu J, Begley D, Mitchell DD, Verlinde CL, Varani G, Fan E. Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions. Chemical Biology & Drug Design. 71: 408-19. PMID 18373548 DOI: 10.1111/J.1747-0285.2008.00648.X |
0.513 |
|
| 2008 |
Arakaki TL, Buckner FS, Gillespie JR, Malmquist NA, Phillips MA, Kalyuzhniy O, Luft JR, Detitta GT, Verlinde CL, Van Voorhis WC, Hol WG, Merritt EA. Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Molecular Microbiology. 68: 37-50. PMID 18312275 DOI: 10.1111/J.1365-2958.2008.06131.X |
0.592 |
|
| 2008 |
Bulbule VJ, Rivas K, Verlinde CL, Van Voorhis WC, Gelb MH. 2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability. Journal of Medicinal Chemistry. 51: 384-7. PMID 18198825 DOI: 10.1021/Jm7013138 |
0.36 |
|
| 2008 |
Olepu S, Suryadevara PK, Rivas K, Yokoyama K, Verlinde CL, Chakrabarti D, Van Voorhis WC, Gelb MH. 2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials. Bioorganic & Medicinal Chemistry Letters. 18: 494-7. PMID 18077162 DOI: 10.1016/J.Bmcl.2007.11.104 |
0.383 |
|
| 2007 |
Bendale P, Olepu S, Suryadevara PK, Bulbule V, Rivas K, Nallan L, Smart B, Yokoyama K, Ankala S, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Buckner FS, Chakrabarti D, ... Verlinde CL, et al. Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials. Journal of Medicinal Chemistry. 50: 4585-605. PMID 17722901 DOI: 10.1021/Jm0703340 |
0.459 |
|
| 2007 |
Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, et al. Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrobial Agents and Chemotherapy. 51: 3659-71. PMID 17606674 DOI: 10.1128/Aac.00246-07 |
0.335 |
|
| 2007 |
Eastman RT, White J, Hucke O, Yokoyama K, Verlinde CL, Hast MA, Beese LS, Gelb MH, Rathod PK, Van Voorhis WC. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Molecular and Biochemical Parasitology. 152: 66-71. PMID 17208314 DOI: 10.1016/J.Molbiopara.2006.11.012 |
0.402 |
|
| 2006 |
Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, ... ... Verlinde CL, et al. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. Journal of Medicinal Chemistry. 49: 5939-46. PMID 17004709 DOI: 10.1021/Jm060429M |
0.641 |
|
| 2006 |
Holmes MA, Buckner FS, Van Voorhis WC, Verlinde CL, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Earnest TN, Hol WG, et al. Structure of ribose 5-phosphate isomerase from Plasmodium falciparum. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 427-31. PMID 16682767 DOI: 10.1107/S1744309106010876 |
0.535 |
|
| 2006 |
Robien MA, Bosch J, Buckner FS, Van Voorhis WC, Worthey EA, Myler P, Mehlin C, Boni EE, Kalyuzhniy O, Anderson L, Lauricella A, Gulde S, Luft JR, DeTitta G, Caruthers JM, ... ... Verlinde CL, et al. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Proteins. 62: 570-7. PMID 16345073 DOI: 10.1002/Prot.20801 |
0.598 |
|
| 2005 |
Hucke O, Gelb MH, Verlinde CL, Buckner FS. The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease. Journal of Medicinal Chemistry. 48: 5415-8. PMID 16107140 DOI: 10.1021/Jm050441Z |
0.429 |
|
| 2005 |
Glenn MP, Chang SY, Hucke O, Verlinde CL, Rivas K, Hornéy C, Yokoyama K, Buckner FS, Pendyala PR, Chakrabarti D, Gelb M, Van Voorhis WC, Sebti SM, Hamilton AD. Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. Angewandte Chemie (International Ed. in English). 44: 4903-6. PMID 16007716 DOI: 10.1002/Anie.200500674 |
0.334 |
|
| 2005 |
Liu J, Zhang Z, Tan X, Hol WG, Verlinde CL, Fan E. Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets. Journal of the American Chemical Society. 127: 2044-5. PMID 15713072 DOI: 10.1021/Ja043817R |
0.587 |
|
| 2005 |
Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. The Journal of Biological Chemistry. 280: 13554-9. PMID 15661734 DOI: 10.1074/Jbc.M413556200 |
0.383 |
|
| 2004 |
Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL. Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases. Chemico-Biological Interactions. 151: 21-32. PMID 15607759 DOI: 10.1016/J.Cbi.2004.10.006 |
0.309 |
|
| 2004 |
Fan E, O'Neal CJ, Mitchell DD, Robien MA, Zhang Z, Pickens JC, Tan XJ, Korotkov K, Roach C, Krumm B, Verlinde CL, Merritt EA, Hol WG. Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin. International Journal of Medical Microbiology : Ijmm. 294: 217-23. PMID 15532979 DOI: 10.1016/J.Ijmm.2004.07.002 |
0.776 |
|
| 2004 |
Zhang Z, Liu J, Verlinde CL, Hol WG, Fan E. Large cyclic peptides as cores of multivalent ligands: application to inhibitors of receptor binding by cholera toxin. The Journal of Organic Chemistry. 69: 7737-40. PMID 15498005 DOI: 10.1021/Jo0489770 |
0.565 |
|
| 2004 |
Pickens JC, Mitchell DD, Liu J, Tan X, Zhang Z, Verlinde CL, Hol WG, Fan E. Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chemistry & Biology. 11: 1205-15. PMID 15380181 DOI: 10.1016/J.Chembiol.2004.06.008 |
0.787 |
|
| 2004 |
Abel EL, Opp SM, Verlinde CL, Bammler TK, Eaton DL. Characterization of atrazine biotransformation by human and murine glutathione S-transferases. Toxicological Sciences : An Official Journal of the Society of Toxicology. 80: 230-8. PMID 15115887 DOI: 10.1093/Toxsci/Kfh152 |
0.353 |
|
| 2003 |
Buckner FS, Joubert BM, Boyle SM, Eastman RT, Verlinde CL, Matsuda SP. Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase. Molecular and Biochemical Parasitology. 132: 75-81. PMID 14599667 DOI: 10.1016/J.Molbiopara.2003.07.004 |
0.353 |
|
| 2003 |
Hu X, Nguyen KT, Verlinde CL, Hol WG, Pei D. Structure-based design of a macrocyclic inhibitor for peptide deformylase. Journal of Medicinal Chemistry. 46: 3771-4. PMID 12930137 DOI: 10.1021/Jm034113F |
0.542 |
|
| 2003 |
Auerbach SS, Ramsden R, Stoner MA, Verlinde C, Hassett C, Omiecinski CJ. Alternatively spliced isoforms of the human constitutive androstane receptor. Nucleic Acids Research. 31: 3194-207. PMID 12799447 DOI: 10.1093/Nar/Gkg419 |
0.388 |
|
| 2002 |
Zhang Z, Merritt EA, Ahn M, Roach C, Hou Z, Verlinde CL, Hol WG, Fan E. Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin. Journal of the American Chemical Society. 124: 12991-8. PMID 12405825 DOI: 10.1021/Ja027584K |
0.619 |
|
| 2002 |
Pickens JC, Merritt EA, Ahn M, Verlinde CL, Hol WG, Fan E. Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Chemistry & Biology. 9: 215-24. PMID 11880036 DOI: 10.1016/S1074-5521(02)00097-2 |
0.813 |
|
| 2001 |
Verlinde CL, Hannaert V, Blonski C, Willson M, Périé JJ, Fothergill-Gilmore LA, Opperdoes FR, Gelb MH, Hol WG, Michels PA. Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 4: 50-65. PMID 11512153 DOI: 10.1054/Drup.2000.0177 |
0.61 |
|
| 2001 |
Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH. Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. Journal of Medicinal Chemistry. 44: 2080-93. PMID 11405646 DOI: 10.1021/Jm000472O |
0.595 |
|
| 2001 |
Suresh S, Bressi JC, Kennedy KJ, Verlinde CL, Gelb MH, Hol WG. Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors. Journal of Molecular Biology. 309: 423-35. PMID 11371162 DOI: 10.1006/Jmbi.2001.4588 |
0.679 |
|
| 2000 |
Fan E, Merritt EA, Verlinde CL, Hol WG. AB(5) toxins: structures and inhibitor design. Current Opinion in Structural Biology. 10: 680-6. PMID 11114505 DOI: 10.1016/S0959-440X(00)00152-4 |
0.622 |
|
| 2000 |
Sokal I, Li N, Verlinde CL, Haeseleer F, Baehr W, Palczewski K. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Biochimica Et Biophysica Acta. 1498: 233-51. PMID 11108966 DOI: 10.1016/S0167-4889(00)00099-9 |
0.313 |
|
| 2000 |
Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. Journal of Medicinal Chemistry. 43: 4135-50. PMID 11063610 DOI: 10.1021/Jm000287A |
0.715 |
|
| 2000 |
Minke WE, Pickens J, Merritt EA, Fan E, Verlinde CL, Hol WG. Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes. Acta Crystallographica. Section D, Biological Crystallography. 56: 795-804. PMID 10930826 DOI: 10.1107/S090744490000514X |
0.784 |
|
| 2000 |
Haeseleer F, Sokal I, Verlinde CL, Erdjument-Bromage H, Tempst P, Pronin AN, Benovic JL, Fariss RN, Palczewski K. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. The Journal of Biological Chemistry. 275: 1247-60. PMID 10625670 DOI: 10.1074/Jbc.275.2.1247 |
0.313 |
|
| 1999 |
Minke WE, Hong F, Verlinde CL, Hol WG, Fan E. Using a galactose library for exploration of a novel hydrophobic pocket in the receptor binding site of the Escherichia coli heat-labile enterotoxin. The Journal of Biological Chemistry. 274: 33469-73. PMID 10559230 DOI: 10.1074/Jbc.274.47.33469 |
0.808 |
|
| 1999 |
Sokal I, Otto-Bruc AE, Surgucheva I, Verlinde CL, Wang CK, Baehr W, Palczewski K. Conformational changes in guanylyl cyclase-activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. The Journal of Biological Chemistry. 274: 19829-37. PMID 10391927 DOI: 10.1074/Jbc.274.28.19829 |
0.318 |
|
| 1999 |
Minke WE, Diller DJ, Hol WG, Verlinde CL. The role of waters in docking strategies with incremental flexibility for carbohydrate derivatives: heat-labile enterotoxin, a multivalent test case. Journal of Medicinal Chemistry. 42: 1778-88. PMID 10346930 DOI: 10.1021/Jm980472C |
0.794 |
|
| 1999 |
Minke WE, Roach C, Hol WG, Verlinde CL. Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists. Biochemistry. 38: 5684-92. PMID 10231518 DOI: 10.1021/Bi982649A |
0.803 |
|
| 1999 |
Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 96: 4273-8. PMID 10200252 DOI: 10.1073/Pnas.96.8.4273 |
0.627 |
|
| 1999 |
Hovey BT, Verlinde CL, Merritt EA, Hol WG. Structure-based discovery of a pore-binding ligand: towards assembly inhibitors for cholera and related AB5 toxins. Journal of Molecular Biology. 285: 1169-78. PMID 9887271 DOI: 10.1006/Jmbi.1998.2340 |
0.769 |
|
| 1999 |
Hol WG, Suresh S, Choe J, Chudzik D, Verlinde CL. Structural motifs in drug target proteins of global infectious agents Comparative Biochemistry and Physiology Part a: Molecular & Integrative Physiology. 124: S57. DOI: 10.1016/S1095-6433(99)90227-1 |
0.676 |
|
| 1998 |
Aronov AM, Verlinde CL, Hol WG, Gelb MH. Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design. Journal of Medicinal Chemistry. 41: 4790-9. PMID 9822549 DOI: 10.1021/Jm9802620 |
0.642 |
|
| 1996 |
Hol WGJ, Merritt E, van den Akker F, Feil I, Sarfaty S, Minke W, Verlinde C. Receptor recognition, protein-carbohydrate interactions and a search for receptor antagonists of the cholera toxin family Acta Crystallographica Section a Foundations of Crystallography. 52: C192-C192. DOI: 10.1107/S0108767396091647 |
0.762 |
|
| 1995 |
Qiu X, Verlinde CL, Zhang S, Schmitt MP, Holmes RK, Hol WG. Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors Structure. 3: 87-100. PMID 7743135 DOI: 10.1016/S0969-2126(01)00137-X |
0.541 |
|
| 1995 |
Verlinde CL, Dijkstra BW. Drug or tool, design or serendipity? Nature Structural Biology. 2: 429-32. PMID 7664101 DOI: 10.1038/Nsb0695-429 |
0.376 |
|
| 1995 |
Kim H, Feil IK, Verlinde CL, Petra PH, Hol WG. Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site. Biochemistry. 34: 14975-86. PMID 7578111 DOI: 10.1021/Bi00046A004 |
0.614 |
|
| 1995 |
Van Calenbergh S, Verlinde CL, Soenens J, De Bruyn A, Callens M, Blaton NM, Peeters OM, Rozenski J, Hol WG, Herdewijn P. Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase. Journal of Medicinal Chemistry. 38: 3838-49. PMID 7562915 DOI: 10.1021/Jm00019A014 |
0.559 |
|
| 1994 |
Verlinde CL, Callens M, Van Calenbergh S, Van Aerschot A, Herdewijn P, Hannaert V, Michels PA, Opperdoes FR, Hol WG. Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. Journal of Medicinal Chemistry. 37: 3605-13. PMID 7932587 DOI: 10.1021/Jm00047A017 |
0.539 |
|
| 1994 |
Verlinde CL, Hol WG. Structure-based drug design: progress, results and challenges. Structure (London, England : 1993). 2: 577-87. PMID 7922037 DOI: 10.1016/S0969-2126(00)00060-5 |
0.506 |
|
| 1994 |
Verlinde CL, Merritt EA, Van den Akker F, Kim H, Feil I, Delboni LF, Mande SC, Sarfaty S, Petra PH, Hol WG. Protein crystallography and infectious diseases. Protein Science : a Publication of the Protein Society. 3: 1670-86. PMID 7849584 DOI: 10.1002/Pro.5560031006 |
0.763 |
|
| 1994 |
Van Calenbergh S, Van Den Eeckhout E, Herdewijn P, De Bruyn A, Verlinde C, Hol W, Callens M, Van Aerschot A, Rozenski J. Synthesis and Conformational Analysis of 2?-Deoxy-2?-(3-methoxybenzamido)adenosine, a rational-designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH) Helvetica Chimica Acta. 77: 631-644. DOI: 10.1002/Hlca.19940770306 |
0.577 |
|
| 1993 |
Van Calenbergh S, Verlinde C, De Bruyn A, Callens M, Van Den Eeckhout E, Van Aerschot A, Michels P, Opperdoes F, Hol W, Herdewijn P. 2'-Substituted adenosine analogues as trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH) inhibitors Collection of Czechoslovak Chemical Communications. 58: 52-55. DOI: 10.1135/Cccc1993S052 |
0.55 |
|
| 1992 |
Verlinde CL, Rudenko G, Hol WG. In search of new lead compounds for trypanosomiasis drug design: a protein structure-based linked-fragment approach. Journal of Computer-Aided Molecular Design. 6: 131-47. PMID 1624956 DOI: 10.1007/Bf00129424 |
0.581 |
|
| 1992 |
Verlinde CL, Witmans CJ, Pijning T, Kalk KH, Hol WG, Callens M, Opperdoes FR. Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation. Protein Science : a Publication of the Protein Society. 1: 1578-84. PMID 1304889 DOI: 10.1002/Pro.5560011205 |
0.65 |
|
| 1991 |
Verlinde CL, Noble ME, Kalk KH, Groendijk H, Wierenga RK, Hol WG. Anion binding at the active site of trypanosomal triosephosphate isomerase. Monohydrogen phosphate does not mimic sulphate. European Journal of Biochemistry / Febs. 198: 53-7. PMID 2040290 DOI: 10.1111/J.1432-1033.1991.Tb15985.X |
0.609 |
|
| 1991 |
Noble ME, Verlinde CL, Groendijk H, Kalk KH, Wierenga RK, Hol WG. Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate. Journal of Medicinal Chemistry. 34: 2709-18. PMID 1895291 DOI: 10.1021/Jm00113A007 |
0.633 |
|
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