| Year |
Citation |
Score |
| 2020 |
Zhang Z, Barros-Álvarez X, Gillespie JR, Ranade RM, Huang W, Shibata S, Molasky NMR, Faghih O, Mushtaq A, Choy RKM, de Hostos E, Hol WGJ, Verlinde CLMJ, Buckner FS, Fan E. Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against . Rsc Medicinal Chemistry. 11: 885-895. PMID 33479683 DOI: 10.1039/d0md00057d |
0.546 |
|
| 2020 |
Michaels SA, Shih HW, Zhang B, Navaluna ED, Zhang Z, Ranade RM, Gillespie JR, Merritt EA, Fan E, Buckner FS, Paredez AR, Ojo KK. Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model. The Journal of Antimicrobial Chemotherapy. PMID 32011682 DOI: 10.1093/Jac/Dkz567 |
0.311 |
|
| 2020 |
Barrett KF, Dranow DM, Phan I, Michaels SA, Shaheen S, Navaluna ED, Craig JK, Tillery LM, Choi R, Edwards TE, Conrady DG, Abendroth J, Horanyi PS, Lorimer DD, Van Voorhis WC, ... ... Fan E, et al. Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis. Protein Science : a Publication of the Protein Society. PMID 31930578 DOI: 10.1002/Pro.3824 |
0.338 |
|
| 2019 |
Buckner FS, Ranade RM, Gillespie JR, Shibata S, Hulverson MA, Zhang Z, Huang W, Choi R, Verlinde CLMJ, Hol WGJ, Ochida A, Akao Y, Choy RKM, Van Voorhis WC, Arnold SLM, ... ... Fan E, et al. Optimization of methionyl tRNA-synthetase inhibitors for treatment of infection. Antimicrobial Agents and Chemotherapy. PMID 30745384 DOI: 10.1128/Aac.02061-18 |
0.566 |
|
| 2019 |
Barrett K, Michaels S, Navaluna E, Siddaramaiah L, Wood G, Phan I, Zhang Z, Staker B, Subramanian S, Totten P, Soge O, Myler P, Suchland R, Barrett L, Voorhis WV, ... Fan E, et al. P316 Structure-based drug design for neisseria gonorrhoeae, chlamydia trachomatis, and mycoplasma genitalium Sexually Transmitted Infections. 95. DOI: 10.1136/Sextrans-2019-Sti.427 |
0.359 |
|
| 2018 |
Hulverson MA, Bruzual I, McConnell EV, Huang W, Vidadala RSR, Choi R, Arnold SLM, Whitman GR, McCloskey MC, Barrett LK, Rivas KL, Scheele S, DeRocher AE, Parsons M, Ojo KK, ... ... Fan E, et al. Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine and 5-Aminopyrazole-4-Carboximide Bumped Kinase Inhibitors against Toxoplasmosis. The Journal of Infectious Diseases. PMID 30423128 DOI: 10.1093/Infdis/Jiy664 |
0.345 |
|
| 2018 |
Barros-Álvarez X, Turley S, Ranade RM, Gillespie JR, Duster NA, Verlinde CLMJ, Fan E, Buckner FS, Hol WGJ. The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate. Acta Crystallographica. Section F, Structural Biology Communications. 74: 245-254. PMID 29633973 DOI: 10.1107/S2053230X18003151 |
0.376 |
|
| 2018 |
Herbst ZM, Shibata S, Fan E, Gelb MH. An Inexpensive, In-House-Made, Microdialysis Device for Measuring Drug-Protein Binding. Acs Medicinal Chemistry Letters. 9: 279-282. PMID 29541374 DOI: 10.1021/Acsmedchemlett.7B00316 |
0.519 |
|
| 2018 |
Vidadala RSR, Golkowski M, Hulverson MA, Choi R, McCloskey MC, Whitman GR, Huang W, Arnold SLM, Barrett LK, Fan E, Merritt EA, Van Voorhis WC, Ojo KK, Maly DJ. 7H-pyrrolo[2,3-d]pyrimidin-4-amine based inhibitors of calcium dependent protein kinase 1 have distinct inhibitory and oral pharmacokinetic characteristics compared with 1H-pyrazolo[3,4-d]pyrimidin-4-amine based inhibitors. Acs Infectious Diseases. PMID 29522315 DOI: 10.1021/Acsinfecdis.7B00224 |
0.351 |
|
| 2017 |
Jiménez-Meléndez A, Ojo KK, Wallace AM, Smith TR, Hemphill A, Balmer V, Regidor-Cerrillo J, Ortega-Mora LM, Hehl AB, Fan E, Maly DJ, Van Voorhis WC, Álvarez-García G. In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites. International Journal For Parasitology. PMID 28899692 DOI: 10.1016/J.Ijpara.2017.08.005 |
0.373 |
|
| 2017 |
Faghih O, Zhang Z, Ranade RM, Gillespie JR, Creason SA, Huang W, Shibata S, Barros-Álvarez X, Verlinde CLMJ, Hol WGJ, Fan E, Buckner FS. Development of methionyl-tRNA synthetase inhibitors as antibiotics for Gram-positive bacterial infections. Antimicrobial Agents and Chemotherapy. PMID 28848016 DOI: 10.1128/Aac.00999-17 |
0.559 |
|
| 2017 |
Arnold SLM, Choi R, Hulverson MA, Schaefer DA, Vinayak S, Vidadala RSR, McCloskey MC, Whitman GR, Huang W, Barrett LK, Ojo KK, Fan E, Maly DJ, Riggs MW, Striepen B, et al. Bumped kinase inhibitor gastrointestinal exposure is necessary to treat Cryptosporidium infection. The Journal of Infectious Diseases. PMID 28541457 DOI: 10.1093/Infdis/Jix247 |
0.308 |
|
| 2017 |
Huang W, Choi R, Hulverson MA, Zhang Z, McCloskey MC, Schaefer DA, Whitman GR, Barrett LK, Vidadala RSR, Riggs MW, Maly DJ, Van Voorhis WC, Ojo KK, Fan E. 5-Aminopyrazole-4-carboxamide based compounds prevent the growth of Cryptosporidium parvum. Antimicrobial Agents and Chemotherapy. PMID 28533246 DOI: 10.1128/Aac.00020-17 |
0.357 |
|
| 2017 |
Huang W, Zhang Z, Ranade RM, Gillespie JR, Barros-Álvarez X, Creason SA, Shibata S, Verlinde CLMJ, Hol WGJ, Buckner FS, Fan E. Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28465105 DOI: 10.1016/J.Bmcl.2017.04.048 |
0.6 |
|
| 2017 |
Barros-Álvarez X, Kerchner KM, Koh CY, Turley S, Pardon E, Steyaert J, Ranade RM, Gillespie JR, Zhang Z, Verlinde CLMJ, Fan E, Buckner FS, Hol WGJ. Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. Biochimie. PMID 28427904 DOI: 10.1016/J.Biochi.2017.04.006 |
0.393 |
|
| 2017 |
Müller J, Aguado-Martínez A, Balmer V, Maly DJ, Fan E, Ortega-Mora LM, Ojo KK, Van Voorhis WC, Hemphill A. Two novel calcium-dependent kinase 1-inhibitors interfere with vertical transmission in mice infected with Neospora caninum tachyzoites. Antimicrobial Agents and Chemotherapy. PMID 28137808 DOI: 10.1128/Aac.02324-16 |
0.323 |
|
| 2017 |
Van Voorhis WC, Doggett JS, Parsons M, Hulverson MA, Choi R, Arnold S, Riggs MW, Hemphill A, Howe DK, Mealey RH, Lau AO, Merritt EA, Maly DJ, Fan E, Ojo KK. Extended-spectrum antiprotozoal bumped kinase inhibitors: A review. Experimental Parasitology. PMID 28065755 DOI: 10.1016/J.Exppara.2017.01.001 |
0.312 |
|
| 2016 |
Schaefer DA, Betzer DP, Smith KD, Millman ZG, Michalski HC, Menchaca SE, Zambriski JA, Ojo KK, Hulverson MA, Arnold SL, Rivas KL, Vidadala RS, Huang W, Barrett LK, Maly DJ, ... Fan E, et al. Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis. The Journal of Infectious Diseases. 214: 1856-1864. PMID 27923949 DOI: 10.1093/Infdis/Jiw488 |
0.329 |
|
| 2016 |
Huang W, Zhang Z, Barros-Álvarez X, Koh CY, Ranade RM, Gillespie JR, Creason SA, Shibata S, Verlinde CL, Hol WG, Buckner FS, Fan E. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. European Journal of Medicinal Chemistry. 124: 1081-1092. PMID 27788467 DOI: 10.1016/J.Ejmech.2016.10.024 |
0.558 |
|
| 2016 |
Huang W, Hulverson MA, Zhang Z, Choi R, Hart KJ, Kennedy M, Vidadala RS, Maly DJ, Van Voorhis WC, Lindner SE, Fan E, Ojo KK. 5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents. Bioorganic & Medicinal Chemistry Letters. PMID 27780638 DOI: 10.1016/J.Bmcl.2016.10.014 |
0.354 |
|
| 2016 |
Castellanos-Gonzalez A, Sparks H, Nava S, Huang W, Zhang Z, Rivas K, Hulverson M, Barrett L, Ojo KK, Fan E, Van Voorhis WC, White AC. A novel calcium dependent kinase inhibitor-1517 cures cryptosporidiosis in immunosuppressed mice. The Journal of Infectious Diseases. PMID 27738055 DOI: 10.1093/Infdis/Jiw481 |
0.351 |
|
| 2016 |
Ojo KK, Dangoudoubiyam S, Verma SK, Scheele S, DeRocher AE, Yeargan M, Choi R, Smith TR, Rivas KL, Hulverson MA, Barrett LK, Fan E, Maly DJ, Parsons M, Dubey JP, et al. Selective inhibition of Sarcocystis neurona calcium-cependent protein kinase 1 for equine protozoal myeloencephalitis therapy. International Journal For Parasitology. PMID 27729271 DOI: 10.1016/J.Ijpara.2016.08.003 |
0.363 |
|
| 2016 |
Zhang Z, Koh CY, Ranade RM, Shibata S, Gillespie JR, Hulverson MA, Huang W, Nguyen J, Pendem N, Gelb MH, Verlinde CL, Hol WG, Buckner FS, Fan E. 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infectious Diseases. 2: 399-404. PMID 27627628 DOI: 10.1021/Acsinfecdis.6B00036 |
0.57 |
|
| 2016 |
Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, Nakazawa Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner FS, Fan E, Van Voorhis WC. Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One. 11: e0160350. PMID 27500735 DOI: 10.1371/Journal.Pone.0160350 |
0.404 |
|
| 2016 |
Vidadala RS, Rivas KL, Ojo KK, Hulverson MA, Zambriski JA, Bruzual I, Schultz TL, Huang W, Zhang Z, Scheele S, DeRocher AE, Choi R, Barrett LK, Siddaramaiah LK, Hol WG, ... Fan E, et al. Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. Journal of Medicinal Chemistry. 59: 6531-46. PMID 27309760 DOI: 10.1021/Acs.Jmedchem.6B00760 |
0.355 |
|
| 2016 |
Li Z, Scott MJ, Fan EK, Li Y, Liu J, Xiao G, Li S, Billiar TR, Wilson MA, Jiang Y, Fan J. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death and Differentiation. PMID 26943325 DOI: 10.1038/cdd.2016.21 |
0.428 |
|
| 2015 |
Huang W, Ojo KK, Zhang Z, Rivas K, Vidadala RS, Scheele S, DeRocher AE, Choi R, Hulverson MA, Barrett LK, Bruzual I, Siddaramaiah LK, Kerchner KM, Kurnick MD, Freiberg GM, ... ... Fan E, et al. SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. Acs Medicinal Chemistry Letters. 6: 1184-1189. PMID 26693272 DOI: 10.1021/Acsmedchemlett.5B00319 |
0.356 |
|
| 2015 |
Ranade RM, Zhang Z, Gillespie JR, Shibata S, Verlinde CL, Hol WG, Fan E, Buckner FS. Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites. Antimicrobial Agents and Chemotherapy. 59: 7128-31. PMID 26324270 DOI: 10.1128/Aac.01573-15 |
0.566 |
|
| 2015 |
Koh CY, Siddaramaiah LK, Ranade RM, Nguyen J, Jian T, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallographica. Section D, Biological Crystallography. 71: 1684-98. PMID 26249349 DOI: 10.1107/S1399004715007683 |
0.43 |
|
| 2015 |
Winzer P, Müller J, Aguado-Martínez A, Rahman M, Balmer V, Manser V, Ortega-Mora LM, Ojo KK, Fan E, Maly DJ, Van Voorhis WC, Hemphill A. In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrobial Agents and Chemotherapy. 59: 6361-74. PMID 26248379 DOI: 10.1128/Aac.01236-15 |
0.326 |
|
| 2015 |
Crowther GJ, Weller SM, Jones JC, Weaver T, Fan E, Van Voorhis WC, Rosen H. The Bacterial Sec Pathway of Protein Export: Screening and Follow-Up. Journal of Biomolecular Screening. PMID 25987586 DOI: 10.1177/1087057115587458 |
0.322 |
|
| 2015 |
Pedró-Rosa L, Buckner FS, Ranade RM, Eberhart C, Madoux F, Gillespie JR, Koh CY, Brown S, Lohse J, Verlinde CL, Fan E, Bannister T, Scampavia L, Hol WG, Spicer T, et al. Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. Journal of Biomolecular Screening. 20: 122-30. PMID 25163684 DOI: 10.1177/1087057114548832 |
0.379 |
|
| 2014 |
Vaidya AB, Morrisey JM, Zhang Z, Das S, Daly TM, Otto TD, Spillman NJ, Wyvratt M, Siegl P, Marfurt J, Wirjanata G, Sebayang BF, Price RN, Chatterjee A, Nagle A, ... ... Fan E, et al. Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum. Nature Communications. 5: 5521. PMID 25422853 DOI: 10.1038/Ncomms6521 |
0.699 |
|
| 2014 |
Keyloun KR, Reid MC, Choi R, Song Y, Fox AM, Hillesland HK, Zhang Z, Vidadala R, Merritt EA, Lau AO, Maly DJ, Fan E, Barrett LK, VAN Voorhis WC, Ojo KK. The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites. Parasitology. 141: 1499-509. PMID 24927073 DOI: 10.1017/S0031182014000857 |
0.419 |
|
| 2014 |
Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness. Plos Neglected Tropical Diseases. 8: e2775. PMID 24743796 DOI: 10.1371/Journal.Pntd.0002775 |
0.708 |
|
| 2014 |
Doggett JS, Ojo KK, Fan E, Maly DJ, Van Voorhis WC. Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection. Antimicrobial Agents and Chemotherapy. 58: 3547-9. PMID 24687502 DOI: 10.1128/Aac.01823-13 |
0.329 |
|
| 2014 |
Ojo KK, Reid MC, Kallur Siddaramaiah L, Müller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A. Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy. Plos One. 9: e92929. PMID 24681759 DOI: 10.1371/Journal.Pone.0092929 |
0.394 |
|
| 2014 |
Vidadala RS, Ojo KK, Johnson SM, Zhang Z, Leonard SE, Mitra A, Choi R, Reid MC, Keyloun KR, Fox AM, Kennedy M, Silver-Brace T, Hume JC, Kappe S, Verlinde CL, ... Fan E, et al. Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. European Journal of Medicinal Chemistry. 74: 562-73. PMID 24531197 DOI: 10.1016/J.Ejmech.2013.12.048 |
0.392 |
|
| 2014 |
Zhang Z, Ojo KK, Vidadala R, Huang W, Geiger JA, Scheele S, Choi R, Reid MC, Keyloun KR, Rivas K, Siddaramaiah LK, Comess KM, Robinson KP, Merta PJ, Kifle L, ... ... Fan E, et al. Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. Acs Medicinal Chemistry Letters. 5: 40-44. PMID 24494061 DOI: 10.1021/Ml400315S |
0.366 |
|
| 2014 |
Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AM, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, ... ... Fan E, et al. A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation. The Journal of Infectious Diseases. 209: 275-84. PMID 24123773 DOI: 10.1093/Infdis/Jit522 |
0.374 |
|
| 2014 |
Koh CY, Nguyen J, Shibata S, Zhang Z, Ranade R, Gillespie JR, Hodder P, Pedro-Rosa L, Bannister T, Buckner F, Verlinde C, Fan E, Hol W. Structure-based drug design against Trypanosoma brucei methionyl-tRNA synthetase Acta Crystallographica Section a Foundations and Advances. 70: C708-C708. DOI: 10.1107/S2053273314092912 |
0.574 |
|
| 2013 |
Castellanos-Gonzalez A, White AC, Ojo KK, Vidadala RS, Zhang Z, Reid MC, Fox AM, Keyloun KR, Rivas K, Irani A, Dann SM, Fan E, Maly DJ, Van Voorhis WC. A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis. The Journal of Infectious Diseases. 208: 1342-8. PMID 23878324 DOI: 10.1093/Infdis/Jit327 |
0.366 |
|
| 2013 |
Khamrui S, Turley S, Pardon E, Steyaert J, Fan E, Verlinde CL, Bergman LW, Hol WG. The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody. Molecular and Biochemical Parasitology. 190: 87-91. PMID 23831371 DOI: 10.1016/J.Molbiopara.2013.06.003 |
0.389 |
|
| 2013 |
Koh CY, Kim JE, Napoli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Hol WG. Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Molecular and Biochemical Parasitology. 189: 26-32. PMID 23665145 DOI: 10.1016/J.Molbiopara.2013.04.007 |
0.404 |
|
| 2013 |
Ranade RM, Gillespie JR, Shibata S, Verlinde CL, Fan E, Hol WG, Buckner FS. Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target. Antimicrobial Agents and Chemotherapy. 57: 3021-8. PMID 23587950 DOI: 10.1128/Aac.02578-12 |
0.533 |
|
| 2012 |
Larson ET, Kim JE, Napuli AJ, Verlinde CL, Fan E, Zucker FH, Van Voorhis WC, Buckner FS, Hol WG, Merritt EA. Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallographica. Section D, Biological Crystallography. 68: 1194-200. PMID 22948920 DOI: 10.1107/S0907444912024699 |
0.349 |
|
| 2012 |
Koh CY, Kim JE, Shibata S, Ranade RM, Yu M, Liu J, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure (London, England : 1993). 20: 1681-91. PMID 22902861 DOI: 10.1016/J.Str.2012.07.011 |
0.698 |
|
| 2012 |
Zhang Z, Ojo KK, Johnson SM, Larson ET, He P, Geiger JA, Castellanos-Gonzalez A, White AC, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E. Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1. Bioorganic & Medicinal Chemistry Letters. 22: 5264-7. PMID 22795629 DOI: 10.1016/J.Bmcl.2012.06.050 |
0.363 |
|
| 2012 |
Shibata S, Gillespie JR, Ranade RM, Koh CY, Kim JE, Laydbak JU, Zucker FH, Hol WG, Verlinde CL, Buckner FS, Fan E. Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. Journal of Medicinal Chemistry. 55: 6342-51. PMID 22720744 DOI: 10.1021/Jm300303E |
0.583 |
|
| 2012 |
Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AM, Reid MC, Dale EJ, Perera BG, Kim J, Hewitt SN, Hol WG, Verlinde CL, ... Fan E, et al. Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. Journal of Medicinal Chemistry. 55: 2803-10. PMID 22369268 DOI: 10.1021/Jm201725V |
0.379 |
|
| 2012 |
Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, et al. Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. Journal of Medicinal Chemistry. 55: 2416-26. PMID 22320388 DOI: 10.1021/Jm201713H |
0.355 |
|
| 2011 |
Shibata S, Zhang Z, Korotkov KV, Delarosa J, Napuli A, Kelley AM, Mueller N, Ross J, Zucker FH, Buckner FS, Merritt EA, Verlinde CL, Van Voorhis WC, Hol WG, Fan E. Screening a fragment cocktail library using ultrafiltration. Analytical and Bioanalytical Chemistry. 401: 1585-91. PMID 21750879 DOI: 10.1007/S00216-011-5225-7 |
0.561 |
|
| 2011 |
Larson ET, Kim JE, Castaneda LJ, Napuli AJ, Zhang Z, Fan E, Zucker FH, Verlinde CL, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA. The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. Journal of Molecular Biology. 409: 159-76. PMID 21420975 DOI: 10.1016/J.Jmb.2011.03.026 |
0.354 |
|
| 2011 |
Shibata S, Gillespie JR, Kelley AM, Napuli AJ, Zhang Z, Kovzun KV, Pefley RM, Lam J, Zucker FH, Van Voorhis WC, Merritt EA, Hol WG, Verlinde CL, Fan E, Buckner FS. Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrobial Agents and Chemotherapy. 55: 1982-9. PMID 21282428 DOI: 10.1128/Aac.01796-10 |
0.602 |
|
| 2011 |
Merritt EA, Arakaki TL, Gillespie R, Napuli AJ, Kim JE, Buckner FS, Van Voorhis WC, Verlinde CL, Fan E, Zucker F, Hol WG. Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Molecular and Biochemical Parasitology. 177: 20-8. PMID 21255615 DOI: 10.1016/J.Molbiopara.2011.01.003 |
0.312 |
|
| 2011 |
Larson ET, Kim JE, Zucker FH, Kelley A, Mueller N, Napuli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG. Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie. 93: 570-82. PMID 21144880 DOI: 10.1016/J.Biochi.2010.11.015 |
0.378 |
|
| 2010 |
Arakaki TL, Carter M, Napuli AJ, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA. The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. Journal of Structural Biology. 171: 238-43. PMID 20438846 DOI: 10.1016/J.Jsb.2010.04.010 |
0.322 |
|
| 2010 |
Merritt EA, Arakaki TL, Gillespie JR, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CL, Fan E, Zucker F, Buckner FS, van Voorhis WC, Hol WG. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. Journal of Molecular Biology. 397: 481-94. PMID 20132829 DOI: 10.1016/J.Jmb.2010.01.051 |
0.373 |
|
| 2010 |
Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, et al. The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. Journal of Molecular Biology. 396: 1244-59. PMID 20070944 DOI: 10.1016/J.Jmb.2010.01.013 |
0.314 |
|
| 2010 |
Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG. Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Molecular and Biochemical Parasitology. 169: 95-100. PMID 19874856 DOI: 10.1016/J.Molbiopara.2009.10.005 |
0.329 |
|
| 2010 |
HAMILTON AD, FAN E, VAN ARMAN S, VICENT C, TELLADO FG, GEIB SJ. ChemInform Abstract: Molecular Recognition. Design of New Receptors for Complexation and Catalysis Cheminform. 25: no-no. DOI: 10.1002/chin.199426309 |
0.403 |
|
| 2010 |
HIRST SC, TECILLA P, GEIB SJ, FAN E, HAMILTON AD. ChemInform Abstract: Molecular Recognition of Phosphate Esters: A Balance of Hydrogen Bonding and Proton Transfer Interactions. Cheminform. 24: no-no. DOI: 10.1002/chin.199310045 |
0.383 |
|
| 2010 |
CHANG S, VAN ENGEN D, FAN E, HAMILTON AD. ChemInform Abstract: Hydrogen Bonding and Molecular Recognition: Synthetic, Complexation, and Structural Studies on Barbiturate Binding to an Artificial Receptor Cheminform. 23: no-no. DOI: 10.1002/chin.199201057 |
0.467 |
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| 2009 |
Verlinde CL, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki TL, Bosch J, Caruthers JM, Larson ET, Letrong I, Napuli A, et al. Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium. Current Topics in Medicinal Chemistry. 9: 1678-87. PMID 19929835 DOI: 10.2174/156802609790102383 |
0.538 |
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| 2009 |
Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, et al. Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. Journal of Biomolecular Screening. 14: 700-7. PMID 19470714 DOI: 10.1177/1087057109335749 |
0.324 |
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| 2008 |
Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA. Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. Journal of Molecular Biology. 381: 975-88. PMID 18602399 DOI: 10.1016/J.Jmb.2008.06.048 |
0.397 |
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| 2008 |
Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, et al. Structural genomics of pathogenic protozoa: an overview. Methods in Molecular Biology (Clifton, N.J.). 426: 497-513. PMID 18542886 DOI: 10.1007/978-1-60327-058-8_33 |
0.302 |
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| 2008 |
Liu J, Begley D, Mitchell DD, Verlinde CL, Varani G, Fan E. Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions. Chemical Biology & Drug Design. 71: 408-19. PMID 18373548 DOI: 10.1111/J.1747-0285.2008.00648.X |
0.621 |
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| 2006 |
Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, ... ... Fan E, et al. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. Journal of Medicinal Chemistry. 49: 5939-46. PMID 17004709 DOI: 10.1021/Jm060429M |
0.421 |
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| 2005 |
Liu J, Zhang Z, Tan X, Hol WG, Verlinde CL, Fan E. Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets. Journal of the American Chemical Society. 127: 2044-5. PMID 15713072 DOI: 10.1021/Ja043817R |
0.554 |
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| 2004 |
Moyersoen J, Choe J, Fan E, Hol WG, Michels PA. Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target. Fems Microbiology Reviews. 28: 603-43. PMID 15539076 DOI: 10.1016/J.Femsre.2004.06.004 |
0.36 |
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| 2004 |
Fan E, O'Neal CJ, Mitchell DD, Robien MA, Zhang Z, Pickens JC, Tan XJ, Korotkov K, Roach C, Krumm B, Verlinde CL, Merritt EA, Hol WG. Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin. International Journal of Medical Microbiology : Ijmm. 294: 217-23. PMID 15532979 DOI: 10.1016/J.Ijmm.2004.07.002 |
0.376 |
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| 2004 |
Zhang Z, Liu J, Verlinde CL, Hol WG, Fan E. Large cyclic peptides as cores of multivalent ligands: application to inhibitors of receptor binding by cholera toxin. The Journal of Organic Chemistry. 69: 7737-40. PMID 15498005 DOI: 10.1021/Jo0489770 |
0.547 |
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| 2004 |
Pickens JC, Mitchell DD, Liu J, Tan X, Zhang Z, Verlinde CL, Hol WG, Fan E. Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chemistry & Biology. 11: 1205-15. PMID 15380181 DOI: 10.1016/J.Chembiol.2004.06.008 |
0.577 |
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| 2004 |
Zhang Z, Pickens JC, Hol WG, Fan E. Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design. Organic Letters. 6: 1377-80. PMID 15101746 DOI: 10.1021/Ol049835V |
0.301 |
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| 2004 |
Mitchell DD, Pickens JC, Korotkov K, Fan E, Hol WG. 3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies. Bioorganic & Medicinal Chemistry. 12: 907-20. PMID 14980603 DOI: 10.1016/J.Bmc.2003.12.019 |
0.428 |
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| 2003 |
Choe J, Moyersoen J, Roach C, Carter TL, Fan E, Michels PA, Hol WG. Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei. Biochemistry. 42: 10915-22. PMID 12974625 DOI: 10.1021/Bi034248N |
0.36 |
|
| 2003 |
Li J, Zhang G, Zhang Z, Fan E. TFA-sensitive arylsulfonylthiourea-assisted synthesis of N,N'-substituted guanidines. The Journal of Organic Chemistry. 68: 1611-4. PMID 12585918 DOI: 10.1021/Jo026807M |
0.48 |
|
| 2002 |
Fan E, Merritt EA. Combating infectious diseases through multivalent design. Current Drug Targets. Infectious Disorders. 2: 161-7. PMID 12462146 DOI: 10.2174/1568005023342588 |
0.372 |
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| 2002 |
Zhang Z, Merritt EA, Ahn M, Roach C, Hou Z, Verlinde CL, Hol WG, Fan E. Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin. Journal of the American Chemical Society. 124: 12991-8. PMID 12405825 DOI: 10.1021/Ja027584K |
0.383 |
|
| 2002 |
Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WG, Fan E. Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. Journal of the American Chemical Society. 124: 8818-24. PMID 12137534 DOI: 10.1021/Ja0202560 |
0.435 |
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| 2002 |
Pickens JC, Merritt EA, Ahn M, Verlinde CL, Hol WG, Fan E. Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Chemistry & Biology. 9: 215-24. PMID 11880036 DOI: 10.1016/S1074-5521(02)00097-2 |
0.417 |
|
| 2001 |
Linton BR, Goodman MS, Fan E, van Arman SA, Hamilton AD. Thermodynamic aspects of dicarboxylate recognition by simple artificial receptors. The Journal of Organic Chemistry. 66: 7313-9. PMID 11681943 DOI: 10.1021/Jo010413Y |
0.721 |
|
| 2001 |
Fan E, Merritt EA, Zhang Z, Pickens JC, Roach C, Ahn M, Hol WG. Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallographica. Section D, Biological Crystallography. 57: 201-12. PMID 11173465 DOI: 10.1107/S0907444900016814 |
0.426 |
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| 2000 |
Fan E, Merritt EA, Verlinde CL, Hol WG. AB(5) toxins: structures and inhibitor design. Current Opinion in Structural Biology. 10: 680-6. PMID 11114505 DOI: 10.1016/S0959-440X(00)00152-4 |
0.417 |
|
| 2000 |
Minke WE, Pickens J, Merritt EA, Fan E, Verlinde CL, Hol WG. Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes. Acta Crystallographica. Section D, Biological Crystallography. 56: 795-804. PMID 10930826 DOI: 10.1107/S090744490000514X |
0.364 |
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| 2000 |
Fan E, Zhang Z, Minke WE, Hou Z, Verlinde CLMJ, Hol WGJ. High-Affinity Pentavalent Ligands ofEscherichia coliHeat-Labile Enterotoxin by Modular Structure-Based Design Journal of the American Chemical Society. 122: 2663-2664. DOI: 10.1021/Ja993388A |
0.328 |
|
| 2000 |
Fan E, Hamilton AD. ChemInform Abstract: Molecular Recognition: Synthetic Approaches to Artificial Receptors Cheminform. 31: no-no. DOI: 10.1002/chin.200041258 |
0.382 |
|
| 1999 |
Minke WE, Hong F, Verlinde CL, Hol WG, Fan E. Using a galactose library for exploration of a novel hydrophobic pocket in the receptor binding site of the Escherichia coli heat-labile enterotoxin. The Journal of Biological Chemistry. 274: 33469-73. PMID 10559230 DOI: 10.1074/Jbc.274.47.33469 |
0.41 |
|
| 1996 |
Fan E, Oei Y, Sweet E, Uno T, Schultz PG. Antibodies with thiol-S-transferase activity Journal of the American Chemical Society. 118: 5474-5475. DOI: 10.1021/Ja9602105 |
0.712 |
|
| 1995 |
Fan E, Yang J, Geib SJ, Stoner TC, Hopkins MD, Hamilton AD. Hydrogen-bonding control of molecular aggregation: Self-complementary subunits lead to rod-shaped structures in the solid state Journal of the Chemical Society, Chemical Communications. 1251-1252. DOI: 10.1039/C39950001251 |
0.397 |
|
| 1994 |
Fan E, Vicent C, Geib SJ, Hamilton AD. Molecular Recognition in the Solid State: Hydrogen-Bonding Control of Molecular Aggregation Chemistry of Materials. 6: 1113-1117. DOI: 10.1021/Cm00044A009 |
0.374 |
|
| 1993 |
Hamilton AD, Fan E, Arman SV, Vicent C, Tellado FG, Geib SJ. Molecular recognition. Design of new receptors for complexation and catalysis Supramolecular Chemistry. 1: 247-252. DOI: 10.1080/10610279308035167 |
0.481 |
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| 1993 |
Yang J, Fan E, Geib SJ, Hamilton AD. Hydrogen-bonding control of molecular self-assembly: formation of a 2 + 2 complex in solution and in the solid state Journal of the American Chemical Society. 115: 5314-5315. DOI: 10.1021/Ja00065A061 |
0.37 |
|
| 1993 |
Fan E, Van Arman SA, Kincaid S, Hamilton AD. Molecular recognition: hydrogen-bonding receptors that function in highly competitive solvents Journal of the American Chemical Society. 115: 369-370. DOI: 10.1021/Ja00054A066 |
0.403 |
|
| 1993 |
Geib SJ, Vicent C, Fan E, Hamilton AD. A Self-Assembling, Hydrogen-Bonded Helix Angewandte Chemie International Edition in English. 32: 119-121. DOI: 10.1002/Anie.199301191 |
0.346 |
|
| 1993 |
Geib SJ, Vicent C, Fan E, Hamilton AD. Selbstorganisation zu einer Helix durch Wasserstoffbrückenbindungen Angewandte Chemie. 105: 83-85. DOI: 10.1002/Ange.19931050115 |
0.335 |
|
| 1992 |
Vicent C, Fan E, Hamilton AD. Molecular recognition: directed hydrogen bonding receptors for acylamino acid carboxylates Tetrahedron Letters. 33: 4269-4272. DOI: 10.1016/S0040-4039(00)74235-3 |
0.44 |
|
| 1992 |
Hirst SC, Tecilla P, Geib SJ, Fan E, Hamilton AD. Molecular Recognition of Phosphate Esters: A Balance of Hydrogen Bonding and Proton Transfer Interactions Israel Journal of Chemistry. 32: 105-111. DOI: 10.1002/Ijch.199200014 |
0.45 |
|
| 1991 |
Chang SK, Van Engen D, Fan E, Hamilton AD. Hydrogen bonding and molecular recognition: synthetic, complexation, and structural studies on barbiturate binding to an artificial receptor Journal of the American Chemical Society. 113: 7640-7645. DOI: 10.1021/Ja00020A027 |
0.467 |
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