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Frederick Cohen, Ph.D. - Publications

Affiliations: 
2001 University of California, Irvine, Irvine, CA 
Area:
synthesis of natural products
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kroeck KG, Sacco MD, Smith EW, Zhang X, Shoun D, Akhtar A, Darch SE, Cohen F, Andrews LD, Knox JE, Chen Y. Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography. Scientific Reports. 9: 15450. PMID 31664082 DOI: 10.1038/S41598-019-51844-Z  0.319
2019 Krause KM, Haglund CM, Hebner C, Serio AW, Lee G, Nieto V, Cohen F, Kane TR, Machajewski TD, Hildebrandt D, Pillar C, Thwaites M, Hall D, Miesel L, Hackel M, et al. Potent LpxC Inhibitors with Activity Against Multi-Drug Resistant . Antimicrobial Agents and Chemotherapy. PMID 31451507 DOI: 10.1128/Aac.00977-19  0.313
2018 Wertz I, Kategaya L, Lello PD, Rouge L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton J, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, ... ... Cohen F, et al. Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Sy23-03  0.366
2017 Di Lello P, Pastor R, Murray JM, Blake RA, Cohen F, Crawford TD, Drobnick J, Drummond J, Kategaya L, Kleinheinz T, Maurer T, Rouge L, Zhao X, Wertz I, Ndubaku C, et al. Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and In-Silico Techniques. Journal of Medicinal Chemistry. PMID 29166018 DOI: 10.1021/Acs.Jmedchem.7B01293  0.331
2017 Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, ... ... Cohen F, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. PMID 29045385 DOI: 10.1038/Nature24006  0.349
2015 Patel S, Cohen F, Dean BJ, De La Torre K, Deshmukh G, Estrada AA, Ghosh AS, Gibbons P, Gustafson A, Huestis MP, Le Pichon CE, Lin H, Liu W, Liu X, Liu Y, et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. Journal of Medicinal Chemistry. 58: 401-18. PMID 25341110 DOI: 10.1021/Jm5013984  0.315
2012 Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, et al. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One. 7: e50864. PMID 23227217 DOI: 10.1371/Journal.Pone.0050864  0.347
2011 Cohen F, Bergeron P, Blackwood E, Bowman KK, Chen H, Dipasquale AG, Epler JA, Koehler MF, Lau K, Lewis C, Liu L, Ly CQ, Malek S, Nonomiya J, Ortwine DF, et al. Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine. Journal of Medicinal Chemistry. 54: 3426-35. PMID 21495671 DOI: 10.1021/Jm200215Y  0.317
2006 Cohen F, Overman LE. Enantioselective total synthesis of batzelladine F and definition of its structure. Journal of the American Chemical Society. 128: 2604-8. PMID 16492044 DOI: 10.1021/Ja057433S  0.469
2006 Cohen F, Overman LE. Evolution of a strategy for the synthesis of structurally complex batzelladine alkaloids. Enantioselective total synthesis of the proposed structure of batzelladine F and structural revision. Journal of the American Chemical Society. 128: 2594-603. PMID 16492043 DOI: 10.1021/Ja0574320  0.479
2006 Overman L, Cohen F. Synthesis of Batzelladine F Synfacts. 2006: 0646-0646. DOI: 10.1055/S-2006-941835  0.451
2004 Olszewski A, Sato K, Aron ZD, Cohen F, Harris A, McDougall BR, Robinson WE, Overman LE, Weiss GA. Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck. Proceedings of the National Academy of Sciences of the United States of America. 101: 14079-84. PMID 15371598 DOI: 10.1073/Pnas.0406040101  0.627
2004 Bewley CA, Ray S, Cohen F, Collins SK, Overman LE. Inhibition of HIV-1 envelope-mediated fusion by synthetic batzelladine analogues. Journal of Natural Products. 67: 1319-24. PMID 15332849 DOI: 10.1021/Np049958O  0.51
2003 Cohen F, Collins SK, Overman LE. Assembling polycyclic bisguanidine motifs resembling batzelladine alkaloids by double tethered Biginelli condensations. Organic Letters. 5: 4485-8. PMID 14602031 DOI: 10.1021/Ol0357999  0.443
2001 Cohen F, Overman LE. Enantioselective total synthesis of batzelladine F: structural revision and stereochemical definition. Journal of the American Chemical Society. 123: 10782-3. PMID 11674029 DOI: 10.1021/Ja017067M  0.414
2001 Cohen F, MacMillan DW, Overman LE, Romero A. Stereoselection in the Prins-pinacol synthesis of acyltetrahydrofurans. Organic Letters. 3: 1225-8. PMID 11348200 DOI: 10.1021/Ol0157003  0.607
1999 Cohen F, Overman LE, Sakata SK. Asymmetric total synthesis of batzelladine D. Organic Letters. 1: 2169-72. PMID 10836070 DOI: 10.1021/Ol991269U  0.472
1998 Cohen F, Overman LE. Planar-chiral cyclopalladated ferrocenyl amines and imines as enantioselective catalysts for allylic imidate rearrangements Tetrahedron Asymmetry. 9: 3213-3222. DOI: 10.1016/S0957-4166(98)00341-3  0.429
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