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Christopher G. Nasveschuk, Ph.D. - Publications

Affiliations: 
2007 Colorado State University, Fort Collins, CO 
Area:
Organic Chemistry, Catalysis
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Crawford TD, Tsui V, Flynn EM, Wang S, Taylor AM, Côté A, Audia JE, Beresini MH, Burdick DJ, Cummings RT, Dakin LA, Duplessis M, Good AC, Hewitt MC, Huang HR, ... ... Nasveschuk CG, et al. Diving into the water: Inducible binding conformations for BRD4, TAF1(2), BRD9, and CECR2 bromodomains. Journal of Medicinal Chemistry. PMID 27219867 DOI: 10.1021/acs.jmedchem.6b00264  0.8
2016 Taylor AM, Côté A, Hewitt MC, Pastor R, Leblanc Y, Nasveschuk CG, Romero FA, Crawford TD, Cantone N, Jayaram H, Setser J, Murray J, Beresini MH, de Leon Boenig G, Chen Z, et al. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Medicinal Chemistry Letters. 7: 531-536. PMID 27190605 DOI: 10.1021/acsmedchemlett.6b00075  0.8
2016 Albrecht BK, Gehling VS, Hewitt MC, Vaswani RG, Cote A, Leblanc Y, Nasveschuk CG, Bellon S, Bergeron L, Campbell R, Cantone N, Cooper MR, Cummings RT, Jayaram H, Joshi S, et al. Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials. Journal of Medicinal Chemistry. PMID 26815195 DOI: 10.1021/acs.jmedchem.5b01882  0.8
2016 Taylor AM, Vaswani RG, Gehling VS, Hewitt MC, Leblanc Y, Audia JE, Bellon S, Cummings RT, Coîté A, Harmange JC, Jayaram H, Joshi S, Lora JM, Mertz JA, Neiss A, ... ... Nasveschuk CG, et al. Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains Acs Medicinal Chemistry Letters. 7: 145-150. DOI: 10.1021/ml500411h  0.8
2015 Hewitt MC, Leblanc Y, Gehling VS, Vaswani RG, Côté A, Nasveschuk CG, Taylor AM, Harmange JC, Audia JE, Pardo E, Cummings R, Joshi S, Sandy P, Mertz JA, Sims RJ, et al. Development of methyl isoxazoleazepines as inhibitors of BET. Bioorganic & Medicinal Chemistry Letters. 25: 1842-8. PMID 25851940 DOI: 10.1016/j.bmcl.2015.03.045  0.8
2015 Gehling VS, Vaswani RG, Nasveschuk CG, Duplessis M, Iyer P, Balasubramanian S, Zhao F, Good AC, Campbell R, Lee C, Dakin LA, Cook AS, Gagnon A, Harmange JC, Audia JE, et al. Discovery, design, and synthesis of indole-based EZH2 inhibitors Bioorganic and Medicinal Chemistry Letters. 25: 3644-3649. DOI: 10.1016/j.bmcl.2015.06.056  0.8
2014 Bradley WD, Arora S, Busby J, Balasubramanian S, Gehling VS, Nasveschuk CG, Vaswani RG, Yuan CC, Hatton C, Zhao F, Williamson KE, Iyer P, Méndez J, Campbell R, Cantone N, et al. EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation. Chemistry & Biology. 21: 1463-75. PMID 25457180 DOI: 10.1016/j.chembiol.2014.09.017  0.8
2014 Vaswani RG, Albrecht BK, Audia JE, Côté A, Dakin LA, Duplessis M, Gehling VS, Harmange JC, Hewitt MC, Leblanc Y, Nasveschuk CG, Taylor AM. A practical synthesis of indoles via a Pd-catalyzed C-N ring formation. Organic Letters. 16: 4114-7. PMID 25068576 DOI: 10.1021/ol5018118  0.8
2014 Nasveschuk CG, Gagnon A, Garapaty-Rao S, Balasubramanian S, Campbell R, Lee C, Zhao F, Bergeron L, Cummings R, Trojer P, Audia JE, Albrecht BK, Harmange JC. Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2. Acs Medicinal Chemistry Letters. 5: 378-83. PMID 24900844 DOI: 10.1021/ml400494b  0.8
2013 Gehling VS, Hewitt MC, Vaswani RG, Leblanc Y, Côté A, Nasveschuk CG, Taylor AM, Harmange JC, Audia JE, Pardo E, Joshi S, Sandy P, Mertz JA, Sims RJ, Bergeron L, et al. Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors. Acs Medicinal Chemistry Letters. 4: 835-40. PMID 24900758 DOI: 10.1021/ml4001485  0.8
2013 Garapaty-Rao S, Nasveschuk C, Gagnon A, Chan EY, Sandy P, Busby J, Balasubramanian S, Campbell R, Zhao F, Bergeron L, Audia JE, Albrecht BK, Harmange JC, Cummings R, Trojer P. Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth. Chemistry & Biology. 20: 1329-39. PMID 24183969 DOI: 10.1016/j.chembiol.2013.09.013  0.8
2012 Ungermannova D, Parker SJ, Nasveschuk CG, Wang W, Quade B, Zhang G, Kuchta RD, Phillips AJ, Liu X. Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). Plos One. 7: e29208. PMID 22279528 DOI: 10.1371/journal.pone.0029208  0.8
2012 Ungermannova D, Parker SJ, Nasveschuk CG, Chapnick DA, Phillips AJ, Kuchta RD, Liu X. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. Journal of Biomolecular Screening. 17: 421-34. PMID 22274912 DOI: 10.1177/1087057111433843  0.8
2008 Nasveschuk CG, Ungermannova D, Liu X, Phillips AJ. A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships. Organic Letters. 10: 3595-8. PMID 18616341 DOI: 10.1021/ol8013478  0.8
2008 Nasveschuk CG, Rovis T. The [1, 3] O-to-C rearrangement: opportunities for stereoselective synthesis. Organic & Biomolecular Chemistry. 6: 240-54. PMID 18174990 DOI: 10.1039/b714881j  0.8
2008 Nasveschuk CG, Rovis T. A diastereoselective ring contraction of 1,3-dioxepins to 2,3,4-trisubstituted and tetrasubstituted tetrahydrofurans. The Journal of Organic Chemistry. 73: 612-7. PMID 18088144 DOI: 10.1021/jo702071v  0.8
2008 Nasveschuk CG, Rovis T. A rapid total synthesis of (±)-sylvone Synlett. 0126-0128. DOI: 10.1055/s-2007-990926  0.8
2007 Nasveschuk CG, Frein JD, Jui NT, Rovis T. A diastereoselective intermolecular heck reaction of 1,3-dioxepins. Organic Letters. 9: 5099-102. PMID 17958436 DOI: 10.1021/ol702294u  0.8
2006 Nasveschuk CG, Jui NT, Rovis T. A modular approach to the synthesis of 2,3,4-trisubstituted tetrahydrofurans. Chemical Communications (Cambridge, England). 3119-21. PMID 16855705 DOI: 10.1039/b605438b  0.8
2005 Nasveschuk CG, Rovis T. Regioselective Lewis acid-mediated [1,3] rearrangement of allylvinyl ethers. Organic Letters. 7: 2173-6. PMID 15901162 DOI: 10.1021/ol0505151  0.8
2005 Nasveschuk CG, Rovis T. Stereoselective Lewis acid mediated [1,3] ring contraction of 2,5-dihydrooxepins as a route to polysubstituted cyclopentenes. Angewandte Chemie (International Ed. in English). 44: 3264-7. PMID 15844118 DOI: 10.1002/anie.200500088  0.8
2004 Byers JH, DeWitt A, Nasveschuk CG, Swigor JE. Tandem radical-electrophilic annulations to pyrrole Tetrahedron Letters. 45: 6587-6590. DOI: 10.1016/j.tetlet.2004.07.037  0.8
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