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Erich E. Wanker - Publications

Affiliations: 
Max Delbruck Center for Molecular Medicine, Berlin, Berlin, Berlin, Germany 
Area:
Neurodegenerative diseases, proteomics
Website:
http://www.mdc-berlin.de/en/research/research_teams/proteomics_and_molecular_mechanisms_of_neurodegenerative_diseases/index.html
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168 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bonsor M, Ammar O, Schnoegl S, Wanker EE, Silva Ramos E. Polyglutamine disease proteins: Commonalities and differences in interaction profiles and pathological effects. Proteomics. e2300114. PMID 38615323 DOI: 10.1002/pmic.202300114  0.387
2023 Alteen MG, Deme JC, Alvarez CP, Loppnau P, Hutchinson A, Seitova A, Chandrasekaran R, Silva Ramos E, Secker C, Alqazzaz M, Wanker EE, Lea SM, Arrowsmith CH, Harding RJ. Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40. Structure (London, England : 1993). PMID 37390814 DOI: 10.1016/j.str.2023.06.002  0.344
2023 Secker C, Motzny AY, Kostova S, Buntru A, Helmecke L, Reus L, Steinfort R, Brusendorf L, Boeddrich A, Neuendorf N, Diez L, Schmieder P, Schulz A, Czekelius C, Wanker EE. The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation. Journal of Neurochemistry. PMID 37165774 DOI: 10.1111/jnc.15842  0.3
2023 Smith EJ, Sathasivam K, Landles C, Osborne GF, Mason MA, Gomez-Paredes C, Taxy BA, Milton RE, Ast A, Schindler F, Zhang C, Duan W, Wanker EE, Bates GP. Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches. Brain Communications. 5: fcad010. PMID 36756307 DOI: 10.1093/braincomms/fcad010  0.319
2022 Greco TM, Secker C, Ramos ES, Federspiel JD, Liu JP, Perez AM, Al-Ramahi I, Cantle JP, Carroll JB, Botas J, Zeitlin SO, Wanker EE, Cristea IM. Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell Systems. PMID 35148841 DOI: 10.1016/j.cels.2022.01.005  0.36
2021 Klockmeier K, Silva Ramos E, Raskó T, Martí Pastor A, Wanker EE. Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells. Journal of Molecular Biology. 167184. PMID 34364876 DOI: 10.1016/j.jmb.2021.167184  0.3
2021 Schindler F, Praedel N, Neuendorf N, Kunz S, Schnoegl S, Mason MA, Taxy BA, Bates GP, Khoshnan A, Priller J, Grimm J, Maier M, Boeddrich A, Wanker EE. Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington's Disease Knock-in Mice. Frontiers in Neuroscience. 15: 682172. PMID 34239412 DOI: 10.3389/fnins.2021.682172  0.325
2020 Poh J, Ponsford AH, Boyd J, Woodsmith J, Stelzl U, Wanker E, Harper N, MacEwan D, Sanderson CM. A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation. Redox Biology. 37: 101686. PMID 32911434 DOI: 10.1016/j.redox.2020.101686  0.325
2020 Haenig C, Atias N, Taylor AK, Mazza A, Schaefer MH, Russ J, Riechers SP, Jain S, Coughlin M, Fontaine JF, Freibaum BD, Brusendorf L, Zenkner M, Porras P, Stroedicke M, ... ... Wanker EE, et al. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Cell Reports. 32: 108050. PMID 32814053 DOI: 10.1016/J.Celrep.2020.108050  0.505
2020 Rieux M, Alpaugh M, Sciacca G, Saint-Pierre M, Masnata M, Denis HL, Lévesque SA, Herrmann F, Bazenet C, Garneau AP, Isenring P, Truant R, Oueslati A, Gould PV, Ast A, ... Wanker EE, et al. Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology. Molecular Psychiatry. PMID 32514103 DOI: 10.1038/s41380-020-0787-4  0.371
2020 Wiglenda T, Groenke N, Hoffmann W, Manz C, Diez L, Buntru A, Brusendorf L, Neuendorf N, Schnoegl S, Haenig C, Schmieder P, Pagel K, Wanker EE. Sclerotiorin stabilizes the assembly of non-fibrillar Abeta42 oligomers with low toxicity, seeding activity and beta-sheet content. Journal of Molecular Biology. PMID 32061932 DOI: 10.1016/j.jmb.2020.01.033  0.345
2019 Choi SG, Olivet J, Cassonnet P, Vidalain PO, Luck K, Lambourne L, Spirohn K, Lemmens I, Dos Santos M, Demeret C, Jones L, Rangarajan S, Bian W, Coutant EP, Janin YL, ... ... Wanker EE, et al. Maximizing binary interactome mapping with a minimal number of assays. Nature Communications. 10: 3907. PMID 31467278 DOI: 10.1038/S41467-019-11809-2  0.359
2019 Wanker EE, Ast A, Schindler F, Trepte P, Schnoegl S. The pathobiology of perturbed mutant huntingtin protein-protein interactions in Huntington's disease. Journal of Neurochemistry. PMID 31418858 DOI: 10.1111/jnc.14853  0.484
2019 Nowak M, Suenkel B, Porras P, Migotti R, Schmidt F, Kny M, Zhu X, Wanker EE, Dittmar G, Fielitz J, Sommer T. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Journal of Cell Science. PMID 31391242 DOI: 10.1242/jcs.233395  0.351
2019 Schilling J, Broemer M, Atanassov I, Duernberger Y, Vorberg I, Dieterich C, Dagane A, Dittmar G, Wanker E, van Roon-Mom W, Winter J, Krauß S. Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease. Journal of Molecular Biology. 431: 1869-1877. PMID 30711541 DOI: 10.1016/j.jmb.2019.01.034  0.348
2018 Boeddrich A, Babila JT, Wiglenda T, Diez L, Jacob M, Nietfeld W, Huska MR, Haenig C, Groenke N, Buntru A, Blanc E, Meier JC, Vannoni E, Erck C, Friedrich B, ... ... Wanker EE, et al. The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice. Cell Chemical Biology. PMID 30472115 DOI: 10.1016/J.Chembiol.2018.10.013  0.34
2018 Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, ... ... Wanker EE, et al. mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease. Molecular Cell. 71: 675-688.e6. PMID 30193095 DOI: 10.1016/J.Molcel.2018.07.032  0.388
2018 Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, ... ... Wanker E, et al. Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Elife. 7. PMID 30179155 DOI: 10.7554/Elife.38744  0.321
2018 Trepte P, Kruse S, Kostova S, Hoffmann S, Buntru A, Tempelmeier A, Secker C, Diez L, Schulz A, Klockmeier K, Zenkner M, Golusik S, Rau K, Schnoegl S, Garner CC, ... Wanker EE, et al. LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells. Molecular Systems Biology. 14: e8071. PMID 29997244 DOI: 10.15252/Msb.20178071  0.434
2018 Ast A, Schindler F, Buntru A, Schnoegl S, Wanker EE. A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples. Methods in Molecular Biology (Clifton, N.J.). 1780: 31-40. PMID 29856013 DOI: 10.1007/978-1-4939-7825-0_3  0.424
2018 Wagner AS, Politi AZ, Ast A, Bravo-Rodriguez K, Baum K, Buntru A, Strempel NU, Brusendorf L, Hänig C, Boeddrich A, Plassmann S, Klockmeier K, Ramirez-Anguita JM, Sanchez-Garcia E, Wolf J, ... Wanker EE, et al. Self-assembly of mutant huntingtin exon-1 fragments into large complex fibrillar structures involves nucleated branching. Journal of Molecular Biology. PMID 29601786 DOI: 10.1016/j.jmb.2018.03.017  0.366
2018 Matthes F, Hettich MM, Schilling J, Flores-Dominguez D, Blank N, Wiglenda T, Buntru A, Wolf H, Weber S, Vorberg I, Dagane A, Dittmar G, Wanker E, Ehninger D, Krauss S. Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis. Cell Death Discovery. 4: 4. PMID 29531801 DOI: 10.1038/s41420-017-0003-8  0.433
2018 Matthes F, Massari S, Bochicchio A, Schorpp K, Schilling J, Weber S, Offermann N, Desantis J, Wanker EE, Carloni P, Hadian K, Tabarrini O, Rossetti G, Krau Szlig S. Reducing mutant Huntingtin protein expression in living cells by a newly identified RNA CAG binder. Acs Chemical Neuroscience. PMID 29506378 DOI: 10.1021/Acschemneuro.8B00027  0.439
2018 Franko A, Rodriguez Camargo DC, Böddrich A, Garg D, Rodriguez Camargo A, Rathkolb B, Janik D, Aichler M, Feuchtinger A, Neff F, Fuchs H, Wanker EE, Reif B, Häring HU, Peter A, et al. Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice. Scientific Reports. 8: 1116. PMID 29348618 DOI: 10.1038/S41598-017-18807-8  0.343
2017 Kankowski S, Förstera B, Winkelmann A, Knauff P, Wanker EE, You XA, Semtner M, Hetsch F, Meier JC. A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy. Frontiers in Molecular Neuroscience. 10: 439. PMID 29375302 DOI: 10.3389/fnmol.2017.00439  0.301
2017 Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J. Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex. The Embo Journal. PMID 29212816 DOI: 10.15252/Embj.201797212  0.446
2017 Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, ... Wanker EE, et al. Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01. Journal of the American Chemical Society. PMID 28406616 DOI: 10.1021/Jacs.6B11039  0.361
2017 Sin O, de Jong T, Mata-Cabana A, Kudron M, Zaini MA, Aprile FA, Seinstra RI, Stroo E, Prins RW, Martineau CN, Wang HH, Hogewerf W, Steinhof A, Wanker EE, Vendruscolo M, et al. Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell. 65: 1096-1108.e6. PMID 28306505 DOI: 10.1016/J.Molcel.2017.02.022  0.48
2017 Rodriguez Camargo DC, Tripsianes K, Buday K, Franko A, Göbl C, Hartlmüller C, Sarkar R, Aichler M, Mettenleiter G, Schulz M, Böddrich A, Erck C, Martens H, Walch AK, Madl T, ... Wanker EE, et al. The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes. Scientific Reports. 7: 44041. PMID 28287098 DOI: 10.1038/Srep44041  0.315
2016 Andrich K, Hegenbart U, Kimmich C, Kedia N, Bergen HR, Schönland S, Wanker EE, Bieschke J. Aggregation of Full Length Immunoglobulin Light Chains from AL Amyloidosis Patients Is Remodeled by Epigallocatechin-3-gallate. The Journal of Biological Chemistry. PMID 28031465 DOI: 10.1074/Jbc.M116.750323  0.352
2016 Goerke S, Milde KS, Bukowiecki R, Kunz P, Klika KD, Wiglenda T, Mogk A, Wanker EE, Bukau B, Ladd ME, Bachert P, Zaiss M. Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins. Nmr in Biomedicine. PMID 27859838 DOI: 10.1002/Nbm.3665  0.439
2016 Arumughan A, Roske Y, Barth C, Forero LL, Bravo-Rodriguez K, Redel A, Kostova S, McShane E, Opitz R, Faelber K, Rau K, Mielke T, Daumke O, Selbach M, Sanchez-Garcia E, ... ... Wanker EE, et al. Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nature Communications. 7: 13047. PMID 27762274 DOI: 10.1038/Ncomms13047  0.371
2016 Lessard-Beaudoin M, Laroche M, Demers MJ, Duclos C, Denault JB, Grenier G, Riechers SP, Wanker EE, Graham RK. Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice. Biogerontology. PMID 27465500 DOI: 10.1007/S10522-016-9651-Y  0.348
2016 Jin S, Kedia N, Illes-Toth E, Haralampiev I, Prisner S, Herrmann A, Wanker EE, Bieschke J. Amyloid-β 1-42 Aggregation Initiates Its Cellular Uptake and Cytotoxicity. The Journal of Biological Chemistry. PMID 27458018 DOI: 10.1074/Jbc.M115.691840  0.362
2016 Mazza A, Klockmeier K, Wanker E, Sharan R. An integer programming framework for inferring disease complexes from network data. Bioinformatics (Oxford, England). 32: i271-i277. PMID 27307626 DOI: 10.1093/bioinformatics/btw263  0.362
2016 Buntru A, Trepte P, Klockmeier K, Schnoegl S, Wanker EE. Current Approaches Toward Quantitative Mapping of the Interactome. Frontiers in Genetics. 7: 74. PMID 27200083 DOI: 10.3389/fgene.2016.00074  0.387
2016 Klein AN, Ziehm T, Tusche M, Buitenhuis J, Bartnik D, Boeddrich A, Wiglenda T, Wanker E, Funke SA, Brener O, Gremer L, Kutzsche J, Willbold D. Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination. Plos One. 11: e0153035. PMID 27105346 DOI: 10.1371/journal.pone.0153035  0.306
2016 Jung B, Messias AC, Schorpp K, Geerlof A, Schneider G, Saur D, Hadian K, Sattler M, Wanker EE, Hasenöder S, Lickert H. Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation. Scientific Reports. 6: 22540. PMID 26931153 DOI: 10.1038/srep22540  0.314
2016 Riechers SP, Butland S, Deng Y, Skotte N, Ehrnhoefer DE, Russ J, Laine J, Laroche M, Pouladi MA, Wanker EE, Hayden MR, Graham RK. Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD. Human Molecular Genetics. PMID 26908611 DOI: 10.1093/Hmg/Ddw036  0.459
2015 Bender J, Engeholm M, Ederer MS, Breu J, Møller TC, Michalakis S, Rasko T, Wanker EE, Biel M, Martinez KL, Wurst W, Deussing JM. Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. Plos One. 10: e0136768. PMID 26352593 DOI: 10.1371/Journal.Pone.0136768  0.358
2015 Trepte P, Buntru A, Klockmeier K, Willmore L, Arumughan A, Secker C, Zenkner M, Brusendorf L, Rau K, Redel A, Wanker EE. DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells. Journal of Molecular Biology. 427: 3375-88. PMID 26264872 DOI: 10.1016/j.jmb.2015.08.003  0.37
2015 Hosp F, Vossfeldt H, Heinig M, Vasiljevic D, Arumughan A, Wyler E, Landthaler M, Hubner N, Wanker EE, Lannfelt L, Ingelsson M, Lalowski M, Voigt A, Selbach M. Quantitative interaction proteomics of neurodegenerative disease proteins. Cell Reports. 11: 1134-46. PMID 25959826 DOI: 10.1016/J.Celrep.2015.04.030  0.451
2015 Stroedicke M, Bounab Y, Strempel N, Klockmeier K, Yigit S, Friedrich RP, Chaurasia G, Li S, Hesse F, Riechers SP, Russ J, Nicoletti C, Boeddrich A, Wiglenda T, Haenig C, ... ... Wanker EE, et al. Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity. Genome Research. 25: 701-13. PMID 25908449 DOI: 10.1101/Gr.182444.114  0.456
2015 Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, Brambilla R, Turco E, Rosenblum K, Wanker EE, et al. Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis. Cell Death and Differentiation. PMID 25678324 DOI: 10.1038/Cdd.2014.227  0.327
2015 Wobst HJ, Sharma A, Diamond MI, Wanker EE, Bieschke J. The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios. Febs Letters. 589: 77-83. PMID 25436420 DOI: 10.1016/J.Febslet.2014.11.026  0.391
2015 Gao M, Estel K, Seeliger J, Friedrich RP, Dogan S, Wanker EE, Winter R, Ebbinghaus S. Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones. Physical Chemistry Chemical Physics : Pccp. 17: 8338-48. PMID 25406896 DOI: 10.1039/C4Cp04682J  0.449
2015 Ito H, Shiwaku H, Yoshida C, Homma H, Luo H, Chen X, Fujita K, Musante L, Fischer U, Frints SG, Romano C, Ikeuchi Y, Shimamura T, Imoto S, Miyano S, ... ... Wanker EE, et al. In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Molecular Psychiatry. 20: 459-71. PMID 25070536 DOI: 10.1038/Mp.2014.69  0.319
2015 Hosp F, Vossfeldt H, Heinig M, Vasiljevic D, Arumughan A, Wyler E, Landthaler M, Hubner N, Wanker EE, Lannfelt L, Ingelsson M, Lalowski M, Voigt A, Selbach M. Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins Cell Reports. 11: 1134-1146. DOI: 10.1016/j.celrep.2015.04.030  0.336
2015 Illes-Toth TE, Shah M, Wu N, Verzini S, Selenko P, Wanker E. Ezrin is a Potent Modulator of Alpha-Synuclein Oligomerization Biophysical Journal. 108: 522a-523a. DOI: 10.1016/J.BPJ.2014.11.2865  0.429
2015 Andrich K, Hegenbart U, Schönland S, Wanker E, Bieschke J. Amyloidogenicity of Immunoglobulin Light Chains Biophysical Journal. 108: 386a. DOI: 10.1016/J.Bpj.2014.11.2117  0.386
2014 Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S. The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. The Journal of Biological Chemistry. 289: 31805-17. PMID 25278022 DOI: 10.1074/jbc.M113.541219  0.351
2014 Suratanee A, Schaefer MH, Betts MJ, Soons Z, Mannsperger H, Harder N, Oswald M, Gipp M, Ramminger E, Marcus G, Männer R, Rohr K, Wanker E, Russell RB, Andrade-Navarro MA, et al. Characterizing protein interactions employing a genome-wide siRNA cellular phenotyping screen. Plos Computational Biology. 10: e1003814. PMID 25255318 DOI: 10.1371/journal.pcbi.1003814  0.4
2014 Trepte P, Strempel N, Wanker EE. Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures. Essays in Biochemistry. 56: 167-80. PMID 25131594 DOI: 10.1042/bse0560167  0.504
2014 Kayatekin C, Matlack KE, Hesse WR, Guan Y, Chakrabortee S, Russ J, Wanker EE, Shah JV, Lindquist S. Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1. Proceedings of the National Academy of Sciences of the United States of America. 111: 12085-90. PMID 25092318 DOI: 10.1073/Pnas.1412504111  0.487
2014 Otte DM, Raskó T, Wang M, Dreiseidler M, Drews E, Schrage H, Wojtalla A, Höhfeld J, Wanker E, Zimmer A. Identification of the mitochondrial MSRB2 as a binding partner of LG72. Cellular and Molecular Neurobiology. 34: 1123-30. PMID 25078755 DOI: 10.1007/s10571-014-0087-0  0.322
2014 Butland SL, Sanders SS, Schmidt ME, Riechers SP, Lin DT, Martin DD, Vaid K, Graham RK, Singaraja RR, Wanker EE, Conibear E, Hayden MR. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Human Molecular Genetics. 23: 4142-60. PMID 24705354 DOI: 10.1093/Hmg/Ddu137  0.443
2014 Dathe C, Daigeler AL, Seifert W, Jankowski V, Mrowka R, Kalis R, Wanker E, Mutig K, Bachmann S, Paliege A. Annexin A2 mediates apical trafficking of renal Na⁺-K⁺-2Cl⁻ cotransporter. The Journal of Biological Chemistry. 289: 9983-97. PMID 24526686 DOI: 10.1074/jbc.M113.540948  0.359
2014 Heinemann U, Roske Y, Arumughan A, Wanker E. Remodeling of the AAA+ ATPase p97 by the UBX Adaptor Protein ASPL Acta Crystallographica Section a Foundations and Advances. 70: C430-C430. DOI: 10.1107/S2053273314095692  0.345
2013 Mielcarek M, Landles C, Weiss A, Bradaia A, Seredenina T, Inuabasi L, Osborne GF, Wadel K, Touller C, Butler R, Robertson J, Franklin SA, Smith DL, Park L, Marks PA, ... Wanker EE, et al. HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration. Plos Biology. 11: e1001717. PMID 24302884 DOI: 10.1371/Journal.Pbio.1001717  0.446
2013 O'Rourke JG, Gareau JR, Ochaba J, Song W, Raskó T, Reverter D, Lee J, Monteys AM, Pallos J, Mee L, Vashishtha M, Apostol BL, Nicholson TP, Illes K, Zhu YZ, ... ... Wanker EE, et al. SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation. Cell Reports. 4: 362-75. PMID 23871671 DOI: 10.1016/J.Celrep.2013.06.034  0.443
2013 Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, ... ... Wanker EE, et al. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases. Nature Communications. 4: 1816. PMID 23652004 DOI: 10.1038/Ncomms2828  0.388
2013 Wallach T, Schellenberg K, Maier B, Kalathur RK, Porras P, Wanker EE, Futschik ME, Kramer A. Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. Plos Genetics. 9: e1003398. PMID 23555304 DOI: 10.1371/journal.pgen.1003398  0.376
2013 Petrakis S, Schaefer MH, Wanker EE, Andrade-Navarro MA. Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 35: 503-7. PMID 23483542 DOI: 10.1002/bies.201300001  0.501
2013 Weimann M, Grossmann A, Woodsmith J, Özkan Z, Birth P, Meierhofer D, Benlasfer N, Valovka T, Timmermann B, Wanker EE, Sauer S, Stelzl U. A Y2H-seq approach defines the human protein methyltransferase interactome. Nature Methods. 10: 339-42. PMID 23455924 DOI: 10.1038/Nmeth.2397  0.387
2013 Krauß S, Griesche N, Jastrzebska E, Chen C, Rutschow D, Achmuller C, Dorn S, Boesch SM, Lalowski M, Wanker E, Schneider R, Schweiger S. Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex Nature Communications. 4. PMID 23443539 DOI: 10.1038/ncomms2514  0.426
2013 Suter B, Fontaine JF, Yildirimman R, Raskó T, Schaefer MH, Rasche A, Porras P, Vázquez-Álvarez BM, Russ J, Rau K, Foulle R, Zenkner M, Saar K, Herwig R, Andrade-Navarro MA, ... Wanker EE, et al. Development and application of a DNA microarray-based yeast two-hybrid system. Nucleic Acids Research. 41: 1496-507. PMID 23275563 DOI: 10.1093/nar/gks1329  0.379
2013 Heinemann U, Arumughan A, Hanna J, Roske Y, Schütz A, Wanker EE. Structural studies of proteins involved in ER-associated protein degradation Acta Crystallographica Section a Foundations of Crystallography. 69: s57-s57. DOI: 10.1107/S0108767313099510  0.402
2013 Heinemann U, Arumughan A, Hanna J, Roske Y, Schütz A, Wanker EE. 213 Structures and interactions of proteins involved in ER-associated protein degradation Journal of Biomolecular Structure and Dynamics. 31: 139-139. DOI: 10.1080/07391102.2013.790144  0.395
2012 Petrakis S, Raskó T, Russ J, Friedrich RP, Stroedicke M, Riechers SP, Muehlenberg K, Möller A, Reinhardt A, Vinayagam A, Schaefer MH, Boutros M, Tricoire H, Andrade-Navarro MA, Wanker EE. Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1. Plos Genetics. 8: e1002897. PMID 22916034 DOI: 10.1371/journal.pgen.1002897  0.458
2012 Schaefer MH, Fontaine JF, Vinayagam A, Porras P, Wanker EE, Andrade-Navarro MA. HIPPIE: Integrating protein interaction networks with experiment based quality scores. Plos One. 7: e31826. PMID 22348130 DOI: 10.1371/journal.pone.0031826  0.394
2012 Lopez del Amo JM, Fink U, Dasari M, Grelle G, Wanker EE, Bieschke J, Reif B. Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers. Journal of Molecular Biology. 421: 517-24. PMID 22300765 DOI: 10.1016/J.Jmb.2012.01.013  0.35
2012 Schaefer MH, Wanker EE, Andrade-Navarro MA. Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks. Nucleic Acids Research. 40: 4273-87. PMID 22287626 DOI: 10.1093/nar/gks011  0.484
2012 Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, ... ... Wanker EE, et al. Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nature Chemical Biology. 8: 93-101. PMID 22101602 DOI: 10.1038/Nchembio.719  0.367
2012 Sommer AP, Bieschke J, Friedrich RP, Zhu D, Wanker EE, Fecht HJ, Mereles D, Hunstein W. 670 nm laser light and EGCG complementarily reduce amyloid-β aggregates in human neuroblastoma cells: basis for treatment of Alzheimer's disease? Photomedicine and Laser Surgery. 30: 54-60. PMID 22029866 DOI: 10.1089/Pho.2011.3073  0.319
2012 Priller J, Nicoletti C, Bounab Y, Grohmann M, Foulle R, Bieschke J, Zabel C, Lalowski M, Wanker E. B16 Collapsin response mediator protein 4 downregulates aggregation and toxicity of mutant huntingtin Journal of Neurology, Neurosurgery & Psychiatry. 83: A10.3-A10. DOI: 10.1136/jnnp-2012-303524.32  0.493
2012 Wanker E. B03 Systematic interactome mapping: understanding the molecular principles of neurodegenerative diseases Journal of Neurology, Neurosurgery & Psychiatry. 83: A6.2-A6. DOI: 10.1136/jnnp-2012-303524.19  0.478
2012 Mielcarek M, Landles C, Weiss A, Bradaia A, Seredenina T, Inuabasi L, Wadel K, Touller C, Butler R, Robertson J, Franklin S, Smith D, Park L, Marks P, Wanker E, et al. A12 HDAC4 interacts with huntington and HDAC4 reduction decreases cytoplamsic aggregation and rescues synaptic dysfunction in HD mouse models Journal of Neurology, Neurosurgery, and Psychiatry. 83. DOI: 10.1136/Jnnp-2012-303524.12  0.406
2011 Tamura T, Sone M, Iwatsubo T, Tagawa K, Wanker EE, Okazawa H. Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease. Plos One. 6: e27408. PMID 22096569 DOI: 10.1371/journal.pone.0027408  0.328
2011 Grelle G, Otto A, Lorenz M, Frank RF, Wanker EE, Bieschke J. Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils. Biochemistry. 50: 10624-36. PMID 22054421 DOI: 10.1021/Bi2012383  0.376
2011 Kunde SA, Musante L, Grimme A, Fischer U, Müller E, Wanker EE, Kalscheuer VM. The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules. Human Molecular Genetics. 20: 4916-31. PMID 21933836 DOI: 10.1093/hmg/ddr430  0.385
2011 Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE. A directed protein interaction network for investigating intracellular signal transduction. Science Signaling. 4: rs8. PMID 21900206 DOI: 10.1126/scisignal.2001699  0.372
2010 Bieschke J, Russ J, Friedrich RP, Ehrnhoefer DE, Wobst H, Neugebauer K, Wanker EE. EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America. 107: 7710-5. PMID 20385841 DOI: 10.1073/Pnas.0910723107  0.377
2010 Goehler H, Dröge A, Lurz R, Schnoegl S, Chernoff YO, Wanker EE. Pathogenic polyglutamine tracts are potent inducers of spontaneous Sup35 and Rnq1 amyloidogenesis. Plos One. 5: e9642. PMID 20224794 DOI: 10.1371/Journal.Pone.0009642  0.404
2010 Wanker E, Strödicke M. S.15.02 Modulation of dysregulated protein-protein-interactions in Huntington's disease European Neuropsychopharmacology. 20: S184-S185. DOI: 10.1016/S0924-977X(10)70178-4  0.321
2010 Vinayagam A, Stelzl U, Wanker EE. Repeated two-hybrid screening detects transient protein-protein interactions Theoretical Chemistry Accounts. 125: 613-619. DOI: 10.1007/s00214-009-0651-8  0.32
2009 Palidwor GA, Shcherbinin S, Huska MR, Rasko T, Stelzl U, Arumughan A, Foulle R, Porras P, Sanchez-Pulido L, Wanker EE, Andrade-Navarro MA. Detection of alpha-rod protein repeats using a neural network and application to huntingtin. Plos Computational Biology. 5: e1000304. PMID 19282972 DOI: 10.1371/journal.pcbi.1000304  0.372
2009 Tamura T, Sone M, Yamashita M, Wanker EE, Okazawa H. Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models. Plos One. 4: e4262. PMID 19165334 DOI: 10.1371/journal.pone.0004262  0.348
2009 Chirasani SR, Markovic DS, Synowitz M, Eichler SA, Wisniewski P, Kaminska B, Otto A, Wanker E, Schäfer M, Chiarugi P, Meier JC, Kettenmann H, Glass R. Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells. Journal of Molecular Medicine (Berlin, Germany). 87: 153-67. PMID 19066835 DOI: 10.1007/S00109-008-0414-3  0.322
2009 Venkatesan K, Rual JF, Vazquez A, Stelzl U, Lemmens I, Hirozane-Kishikawa T, Hao T, Zenkner M, Xin X, Goh KI, Yildirim MA, Simonis N, Heinzmann K, Gebreab F, Sahalie JM, ... ... Wanker EE, et al. An empirical framework for binary interactome mapping. Nature Methods. 6: 83-90. PMID 19060904 DOI: 10.1038/Nmeth.1280  0.324
2009 Chaurasia G, Malhotra S, Russ J, Schnoegl S, Hänig C, Wanker EE, Futschik ME. UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome. Nucleic Acids Research. 37: D657-60. PMID 18984619 DOI: 10.1093/nar/gkn841  0.398
2008 Inagaki R, Tagawa K, Qi ML, Enokido Y, Ito H, Tamura T, Shimizu S, Oyanagi K, Arai N, Kanazawa I, Wanker EE, Okazawa H. Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease. The European Journal of Neuroscience. 28: 30-40. PMID 18662332 DOI: 10.1111/j.1460-9568.2008.06323.x  0.346
2008 Zolghadr K, Mortusewicz O, Rothbauer U, Kleinhans R, Goehler H, Wanker EE, Cardoso MC, Leonhardt H. A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells. Molecular & Cellular Proteomics : McP. 7: 2279-87. PMID 18622019 DOI: 10.1074/mcp.M700548-MCP200  0.301
2008 Ehrnhoefer DE, Bieschke J, Boeddrich A, Herbst M, Masino L, Lurz R, Engemann S, Pastore A, Wanker EE. EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nature Structural & Molecular Biology. 15: 558-66. PMID 18511942 DOI: 10.1038/Nsmb.1437  0.392
2008 Aranda-Orgillés B, Trockenbacher A, Winter J, Aigner J, Köhler A, Jastrzebska E, Stahl J, Müller EC, Otto A, Wanker EE, Schneider R, Schweiger S. The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex. Human Genetics. 123: 163-76. PMID 18172692 DOI: 10.1007/s00439-007-0456-6  0.387
2007 Herbst M, Wanker EE. Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy. Neuro-Degenerative Diseases. 4: 254-60. PMID 17596719 DOI: 10.1159/000101849  0.418
2007 Qi ML, Tagawa K, Enokido Y, Yoshimura N, Wada Y, Watase K, Ishiura S, Kanazawa I, Botas J, Saitoe M, Wanker EE, Okazawa H. Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases. Nature Cell Biology. 9: 402-14. PMID 17384639 DOI: 10.1038/Ncb1553  0.465
2007 Tagawa K, Marubuchi S, Qi ML, Enokido Y, Tamura T, Inagaki R, Murata M, Kanazawa I, Wanker EE, Okazawa H. The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 868-80. PMID 17251428 DOI: 10.1523/JNEUROSCI.4522-06.2007  0.371
2007 Chaurasia G, Iqbal Y, Hänig C, Herzel H, Wanker EE, Futschik ME. UniHI: an entry gate to the human protein interactome. Nucleic Acids Research. 35: D590-4. PMID 17158159 DOI: 10.1093/Nar/Gkl817  0.387
2007 Hübbers CU, Clemen CS, Kesper K, Böddrich A, Hofmann A, Kämäräinen O, Tolksdorf K, Stumpf M, Reichelt J, Roth U, Krause S, Watts G, Kimonis V, Wattjes MP, Reimann J, ... ... Wanker EE, et al. Pathological consequences of VCP mutations on human striated muscle. Brain : a Journal of Neurology. 130: 381-93. PMID 16984901 DOI: 10.1093/brain/awl238  0.366
2007 Chaurasia G, Iqbal Y, Hänig C, Herzel H, Wanker EE, Futschik ME. Flexible web-based integration of distributed large-scale human protein interaction maps Journal of Integrative Bioinformatics. 4: 40-50. DOI: 10.1515/Jib-2007-51  0.39
2007 Herbst M, Bieschke J, Wang Q, Lurz R, Boeddrich A, Otto A, Anwyl R, Walsh D, Wanker E. Induction of fibril-like beta-amyloid aggregates by a natural substance decreases soluble oligomers and protects from neurotoxicity Aktuelle Neurologie. 34. DOI: 10.1055/s-2007-987948  0.313
2006 Chaurasia G, Herzel H, Wanker EE, Futschik ME. Systematic functional assessment of human protein-protein interaction maps. Genome Informatics. International Conference On Genome Informatics. 17: 36-45. PMID 17503354 DOI: 10.11234/Gi1990.17.36  0.386
2006 Weidemann W, Stelzl U, Lisewski U, Bork K, Wanker EE, Hinderlich S, Horstkorte R. The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis. Febs Letters. 580: 6649-54. PMID 17118363 DOI: 10.1016/j.febslet.2006.11.015  0.439
2006 Stelzl U, Wanker EE. The value of high quality protein-protein interaction networks for systems biology. Current Opinion in Chemical Biology. 10: 551-8. PMID 17055769 DOI: 10.1016/j.cbpa.2006.10.005  0.404
2006 Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE. Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Human Molecular Genetics. 15: 2743-51. PMID 16893904 DOI: 10.1093/Hmg/Ddl210  0.495
2006 Herbst M, Wanker EE. Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation. Current Pharmaceutical Design. 12: 2543-55. PMID 16842177 DOI: 10.2174/138161206777698828  0.46
2006 Horn SC, Lalowski M, Goehler H, Dröge A, Wanker EE, Stelzl U. Huntingtin interacts with the receptor sorting family protein GASP2. Journal of Neural Transmission (Vienna, Austria : 1996). 113: 1081-90. PMID 16835690 DOI: 10.1007/s00702-006-0514-6  0.447
2006 Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert BO, Müller EC, Lurz R, Breuer P, Schugardt N, Plassmann S, Xu K, Warrick JM, Suopanki J, Wüllner U, ... ... Wanker EE, et al. An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. The Embo Journal. 25: 1547-58. PMID 16525503 DOI: 10.1038/sj.emboj.7601043  0.424
2006 Hoshino M, Qi ML, Yoshimura N, Miyashita T, Tagawa K, Wada Y, Enokido Y, Marubuchi S, Harjes P, Arai N, Oyanagi K, Blandino G, Sudol M, Rich T, Kanazawa I, ... Wanker EE, et al. Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. The Journal of Cell Biology. 172: 589-604. PMID 16461361 DOI: 10.1083/Jcb.200509132  0.325
2006 Suopanki J, Götz C, Lutsch G, Schiller J, Harjes P, Herrmann A, Wanker EE. Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease. Journal of Neurochemistry. 96: 870-84. PMID 16405500 DOI: 10.1111/J.1471-4159.2005.03620.X  0.382
2006 Grelle G, Kostka S, Otto A, Kersten B, Genser KF, Müller EC, Wälter S, Böddrich A, Stelzl U, Hänig C, Volkmer-Engert R, Landgraf C, Alberti S, Höhfeld J, Strödicke M, ... Wanker EE, et al. Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Molecular & Cellular Proteomics : McP. 5: 234-44. PMID 16275660 DOI: 10.1074/mcp.M500198-MCP200  0.449
2006 Hockly E, Tse J, Barker AL, Moolman DL, Beunard JL, Revington AP, Holt K, Sunshine S, Moffitt H, Sathasivam K, Woodman B, Wanker EE, Lowden PA, Bates GP. Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease. Neurobiology of Disease. 21: 228-36. PMID 16111888 DOI: 10.1016/j.nbd.2005.07.007  0.409
2006 Stelzl U, Wanker E. Protein-Wechselwirkungsnetzwerke: Aufklärung der Funktion von Proteinen Biologie in Unserer Zeit. 36: 12-13. DOI: 10.1002/BIUZ.200690002  0.401
2005 Mirgorodskaya E, Wanker E, Otto A, Lehrach H, Gobom J. Method for qualitative comparisons of protein mixtures based on enzyme-catalyzed stable-isotope incorporation. Journal of Proteome Research. 4: 2109-16. PMID 16335956 DOI: 10.1021/Pr050219I  0.523
2005 Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, ... ... Wanker EE, et al. A human protein-protein interaction network: a resource for annotating the proteome. Cell. 122: 957-68. PMID 16169070 DOI: 10.1016/J.Cell.2005.08.029  0.56
2005 Ralser M, Goehler H, Wanker EE, Lehrach H, Krobitsch S. Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis. Biotechniques. 39: 165-6, 168. PMID 16116786 DOI: 10.2144/05392BM01  0.572
2005 Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker EE, Lehrach H, Krobitsch S. Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. Human Molecular Genetics. 14: 2893-909. PMID 16115810 DOI: 10.1093/hmg/ddi321  0.532
2005 Kersten B, Wanker EE, Hoheisel JD, Angenendt P. Multiplex approaches in protein microarray technology. Expert Review of Proteomics. 2: 499-510. PMID 16097884 DOI: 10.1586/14789450.2.4.499  0.31
2005 Karapetian RN, Evstafieva AG, Abaeva IS, Chichkova NV, Filonov GS, Rubtsov YP, Sukhacheva EA, Melnikov SV, Schneider U, Wanker EE, Vartapetian AB. Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes. Molecular and Cellular Biology. 25: 1089-99. PMID 15657435 DOI: 10.1128/MCB.25.3.1089-1099.2005  0.315
2005 Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, et al. A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 892-7. PMID 15642944 DOI: 10.1073/pnas.0408936102  0.424
2005 Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker E, Lehrach H, Krobitsch S. Functional association of the polyglutamine proteins ataxin-2 and huntingtin Gbm Annual Fall Meeting Berlin/Potsdam 2005. 2005. DOI: 10.1240/SAV_GBM_2005_H_001239  0.464
2005 Lücking C, Dächsel J, Deeg S, Schulz E, Casademunt E, Hampe C, Patenge N, Corti O, Vaupel K, Dichgans M, Kahle P, Genser K, Brice A, Wanker E, Gasser T. Identifikation eines neuen Parkin-Protein-Interaktors Aktuelle Neurologie. 32. DOI: 10.1055/S-2005-866696  0.303
2004 Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, ... ... Wanker EE, et al. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Molecular Cell. 15: 853-65. PMID 15383276 DOI: 10.1016/J.Molcel.2004.09.016  0.598
2004 Albrecht AN, Kornak U, Böddrich A, Süring K, Robinson PN, Stiege AC, Lurz R, Stricker S, Wanker EE, Mundlos S. A molecular pathogenesis for transcription factor associated poly-alanine tract expansions. Human Molecular Genetics. 13: 2351-9. PMID 15333588 DOI: 10.1093/Hmg/Ddh277  0.462
2004 Tagawa K, Hoshino M, Okuda T, Ueda H, Hayashi H, Engemann S, Okado H, Ichikawa M, Wanker EE, Okazawa H. Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein. Journal of Neurochemistry. 89: 974-87. PMID 15140196 DOI: 10.1111/J.1471-4159.2004.02372.X  0.368
2004 Qin ZH, Wang Y, Sapp E, Cuiffo B, Wanker E, Hayden MR, Kegel KB, Aronin N, DiFiglia M. Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 269-81. PMID 14715959 DOI: 10.1523/Jneurosci.1409-03.2004  0.441
2004 Herbst M, Engemann S, Walther J, Lurz R, Heiser V, Wanker EE. Compounds that inhibit amyloid formation of Huntington's and Alzheimer's disease proteins imply a common aggregation pathway Aktuelle Neurologie. 31. DOI: 10.1055/S-2004-832977  0.418
2003 Laurine E, Grégoire C, Fändrich M, Engemann S, Marchal S, Thion L, Mohr M, Monsarrat B, Michel B, Dobson CM, Wanker E, Érard M, Verdier JM. Lithostathine Quadruple-helical Filaments Form Proteinase K-resistant Deposits in Creutzfeldt-Jakob Disease Journal of Biological Chemistry. 278: 51770-51778. PMID 13129929 DOI: 10.1074/Jbc.M306767200  0.405
2003 Hoshino M, Tagawa K, Okuda T, Murata M, Oyanagi K, Arai N, Mizutani T, Kanazawa I, Wanker EE, Okazawa H. Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein. Journal of Neurochemistry. 87: 257-67. PMID 12969272 DOI: 10.1046/J.1471-4159.2003.01991.X  0.421
2003 Harjes P, Wanker EE. The hunt for huntingtin function: interaction partners tell many different stories. Trends in Biochemical Sciences. 28: 425-33. PMID 12932731 DOI: 10.1016/S0968-0004(03)00168-3  0.489
2003 Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease. The Journal of Biological Chemistry. 278: 41452-61. PMID 12888569 DOI: 10.1074/Jbc.M303354200  0.555
2003 Boeddrich A, Lurz R, Wanker EE. Huntingtin fragments form aggresome-like inclusion bodies in mammalian cells. Methods in Molecular Biology (Clifton, N.J.). 232: 217-29. PMID 12840552 DOI: 10.1385/1-59259-394-1:217  0.334
2003 Ross CA, Poirier MA, Wanker EE, Amzel M. Polyglutamine fibrillogenesis: the pathway unfolds. Proceedings of the National Academy of Sciences of the United States of America. 100: 1-3. PMID 12509507 DOI: 10.1073/Pnas.0237018100  0.345
2002 Heiser V, Engemann S, Bröcker W, Dunkel I, Boeddrich A, Waelter S, Nordhoff E, Lurz R, Schugardt N, Rautenberg S, Herhaus C, Barnickel G, Böttcher H, Lehrach H, Wanker EE. Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay. Proceedings of the National Academy of Sciences of the United States of America. 99: 16400-6. PMID 12200548 DOI: 10.1073/Pnas.182426599  0.567
2002 Möncke-Buchner E, Reich S, Mücke M, Reuter M, Messer W, Wanker EE, Krüger DH. Counting CAG repeats in the Huntington's disease gene by restriction endonuclease EcoP15I cleavage. Nucleic Acids Research. 30: e83. PMID 12177311 DOI: 10.1093/Nar/Gnf082  0.332
2002 Perutz MF, Pope BJ, Owen D, Wanker EE, Scherzinger E. Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques. Proceedings of the National Academy of Sciences of the United States of America. 99: 5596-600. PMID 11960015 DOI: 10.1073/pnas.042681599  0.368
2002 Wanker EE. Hip1 and Hippi participate in a novel cell death-signaling pathway. Developmental Cell. 2: 126-8. PMID 11832235 DOI: 10.1016/S1534-5807(02)00121-1  0.326
2001 Lehrach H, Wanker EE. Huntington's disease: from gene to potential therapy. Dialogues in Clinical Neuroscience. 3: 17-23. PMID 22034471  0.469
2001 Smith DL, Portier R, Woodman B, Hockly E, Mahal A, Klunk WE, Li XJ, Wanker E, Murray KD, Bates GP. Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles. Neurobiology of Disease. 8: 1017-26. PMID 11741397 DOI: 10.1006/nbdi.2001.0438  0.383
2001 Sathasivam K, Woodman B, Mahal A, Bertaux F, Wanker EE, Shima DT, Bates GP. Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients. Human Molecular Genetics. 10: 2425-35. PMID 11689489 DOI: 10.1093/Hmg/10.21.2425  0.338
2001 Waelter S, Scherzinger E, Hasenbank R, Nordhoff E, Lurz R, Goehler H, Gauss C, Sathasivam K, Bates GP, Lehrach H, Wanker EE. The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. Human Molecular Genetics. 10: 1807-17. PMID 11532990 DOI: 10.1093/Hmg/10.17.1807  0.517
2001 Sittler A, Lurz R, Lueder G, Priller J, Lehrach H, Hayer-Hartl MK, Hartl FU, Wanker EE. Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Human Molecular Genetics. 10: 1307-15. PMID 11406612 DOI: 10.1093/Hmg/10.12.1307  0.52
2001 Waelter S, Boeddrich A, Lurz R, Scherzinger E, Lueder G, Lehrach H, Wanker EE. Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. Molecular Biology of the Cell. 12: 1393-407. PMID 11359930 DOI: 10.1091/Mbc.12.5.1393  0.587
2000 Wanker EE. Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations. Biological Chemistry. 381: 937-42. PMID 11076024 DOI: 10.1515/BC.2000.114  0.446
2000 Wanker EE. Protein aggregation in Huntington's and Parkinson's disease: implications for therapy. Molecular Medicine Today. 6: 387-91. PMID 11006527 DOI: 10.1016/S1357-4310(00)01761-5  0.463
2000 Muchowski PJ, Schaffar G, Sittler A, Wanker EE, Hayer-Hartl MK, Hartl FU. Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proceedings of the National Academy of Sciences of the United States of America. 97: 7841-6. PMID 10859365 DOI: 10.1073/Pnas.140202897  0.434
2000 Heiser V, Scherzinger E, Boeddrich A, Nordhoff E, Lurz R, Schugardt N, Lehrach H, Wanker EE. Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. Proceedings of the National Academy of Sciences of the United States of America. 97: 6739-44. PMID 10829068 DOI: 10.1073/Pnas.110138997  0.584
2000 Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H, Wanker EE, Bates GP, Housman DE, Thompson LM. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proceedings of the National Academy of Sciences of the United States of America. 97: 6763-8. PMID 10823891 DOI: 10.1073/pnas.100110097  0.467
1999 Starikov EB, Lehrach H, Wanker EE. Folding of oligoglutamines: a theoretical approach based upon thermodynamics and molecular mechanics. Journal of Biomolecular Structure & Dynamics. 17: 409-27. PMID 10636078 DOI: 10.1080/07391102.1999.10508374  0.473
1999 Davies SW, Sathasivam K, Hobbs C, Doherty P, Mangiarini L, Scherzinger E, Wanker EE, Bates GP. Detection of polyglutamine aggregation in mouse models. Methods in Enzymology. 309: 687-701. PMID 10507055 DOI: 10.1016/S0076-6879(99)09045-X  0.384
1999 Wanker EE, Scherzinger E, Heiser V, Sittler A, Eickhoff H, Lehrach H. Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates. Methods in Enzymology. 309: 375-86. PMID 10507036 DOI: 10.1016/S0076-6879(99)09026-6  0.597
1999 Hollenbach B, Scherzinger E, Schweiger K, Lurz R, Lehrach H, Wanker EE. Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 991-4. PMID 10434297 DOI: 10.1098/Rstb.1999.0450  0.596
1999 Scherzinger E, Sittler A, Schweiger K, Heiser V, Lurz R, Hasenbank R, Bates GP, Lehrach H, Wanker EE. Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology. Proceedings of the National Academy of Sciences of the United States of America. 96: 4604-9. PMID 10200309 DOI: 10.1073/Pnas.96.8.4604  0.561
1999 Sathasivam K, Hobbs C, Turmaine M, Mangiarini L, Mahal A, Bertaux F, Wanker EE, Doherty P, Davies SW, Bates GP. Formation of polyglutamine inclusions in non-CNS tissue. Human Molecular Genetics. 8: 813-22. PMID 10196370 DOI: 10.1093/Hmg/8.5.813  0.404
1999 Sieradzan KA, Mechan AO, Jones L, Wanker EE, Nukina N, Mann DM. Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein. Experimental Neurology. 156: 92-9. PMID 10192780 DOI: 10.1006/Exnr.1998.7005  0.364
1998 Zechner U, Scheel S, Hemberger M, Hopp M, Haaf T, Fundele R, Wanker EE, Lehrach H, Wedemeyer N, Himmelbauer H. Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2. Genomics. 54: 505-10. PMID 9878254 DOI: 10.1006/Geno.1998.5584  0.523
1998 Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE. SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. Molecular Cell. 2: 427-36. PMID 9809064 DOI: 10.1016/S1097-2765(00)80142-2  0.613
1998 Bates GP, Mangiarini L, Wanker EE, Davies SW. Polyglutamine expansion and Huntington's disease. Biochemical Society Transactions. 26: 471-5. PMID 9765898 DOI: 10.1042/Bst0260471  0.308
1998 Georgalis Y, Starikov EB, Hollenbach B, Lurz R, Scherzinger E, Saenger W, Lehrach H, Wanker EE. Huntingtin aggregation monitored by dynamic light scattering. Proceedings of the National Academy of Sciences of the United States of America. 95: 6118-21. PMID 9600927 DOI: 10.1073/Pnas.95.11.6118  0.479
1998 Bertaux F, Sharp AH, Ross CA, Lehrach H, Bates GP, Wanker E. HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice. Febs Letters. 426: 229-32. PMID 9599014 DOI: 10.1016/S0014-5793(98)00352-4  0.575
1998 Tait D, Riccio M, Sittler A, Scherzinger E, Santi S, Ognibene A, Maraldi NM, Lehrach H, Wanker EE. Ataxin-3 is transported into the nucleus and associates with the nuclear matrix. Human Molecular Genetics. 7: 991-7. PMID 9580663 DOI: 10.1093/Hmg/7.6.991  0.535
1998 Himmelbauer H, Wedemeyer N, Haaf T, Wanker EE, Schalkwyk LC, Lehrach H. IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse chromosome 5. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 26-31. PMID 9434941 DOI: 10.1007/S003359900674  0.511
1997 Wedemeyer N, Peoples R, Himmelbauer H, Lehrach H, Francke U, Wanker EE. Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11.23. Genomics. 46: 313-5. PMID 9417924 DOI: 10.1006/Geno.1997.5027  0.405
1997 Scherzinger E, Lurz R, Turmaine M, Mangiarini L, Hollenbach B, Hasenbank R, Bates GP, Davies SW, Lehrach H, Wanker EE. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell. 90: 549-58. PMID 9267034 DOI: 10.1016/S0092-8674(00)80514-0  0.593
1997 Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, Ross CA, Scherzinger E, Wanker EE, Mangiarini L, Bates GP. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell. 90: 537-48. PMID 9267033 DOI: 10.1016/S0092-8674(00)80513-9  0.379
1997 Wanker EE, Rovira C, Scherzinger E, Hasenbank R, Wälter S, Tait D, Colicelli J, Lehrach H. HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system. Human Molecular Genetics. 6: 487-95. PMID 9147654 DOI: 10.1093/Hmg/6.3.487  0.549
1995 Wanker EE, Sun Y, Savitz AJ, Meyer DI. Functional characterization of the 180-kD ribosome receptor in vivo. The Journal of Cell Biology. 130: 29-39. PMID 7790375 DOI: 10.1083/jcb.130.1.29  0.529
1995 Wanker E, Klingsbichel E, Schwab H. Efficient secretion of bacillus subtilis levanase by saccharomyces cerevisiae Gene. 161: 45-49. PMID 7642135 DOI: 10.1016/0378-1119(95)00284-D  0.34
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