Dimitar Nikolov - Publications

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
Molecular Biology, Biochemistry

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Saha N, Robev D, Himanen JP, Nikolov DB. ADAM proteases: Emerging role and targeting of the non-catalytic domains. Cancer Letters. 467: 50-57. PMID 31593799 DOI: 10.1016/j.canlet.2019.10.003  0.68
2019 Laing ED, Navaratnarajah CK, Cheliout Da Silva S, Petzing SR, Xu Y, Sterling SL, Marsh GA, Wang LF, Amaya M, Nikolov DB, Cattaneo R, Broder CC, Xu K. Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus. Proceedings of the National Academy of Sciences of the United States of America. PMID 31548390 DOI: 10.1073/pnas.1911773116  0.68
2018 Saha N, Robev D, Mason E, Himanen JP, Nikolov DB. Therapeutic potential of targeting the Eph/ephrin signaling complex. The International Journal of Biochemistry & Cell Biology. PMID 30343150 DOI: 10.1016/j.biocel.2018.10.006  0.68
2018 Liu Y, Kaljunen H, Pavić A, Saarenpää T, Himanen JP, Nikolov DB, Goldman A. Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study. Plos One. 13: e0198291. PMID 29889908 DOI: 10.1371/journal.pone.0198291  0.68
2017 Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. Cell. 171: 1638-1648.e7. PMID 29224781 DOI: 10.1016/j.cell.2017.11.014  0.68
2016 Atapattu L, Saha N, Chheang C, Eissman MF, Xu K, Vail ME, Hii L, Llerena C, Liu Z, Horvay K, Abud HE, Kusebauch U, Moritz RL, Ding BS, Cao Z, ... ... Nikolov DB, et al. An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. The Journal of Experimental Medicine. PMID 27503072 DOI: 10.1084/jem.20151095  0.68
2015 Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB. Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. Plos Pathogens. 11: e1005322. PMID 26646856 DOI: 10.1371/journal.ppat.1005322  1
2015 Lamminmaki U, Nikolov D, Himanen J. Eph Receptors as Drug Targets: Single-Chain Antibodies and Beyond. Current Drug Targets. 16: 1021-30. PMID 26028047  1
2015 Xu K, Olsen O, Tzvetkova-Robev D, Tessier-Lavigne M, Nikolov DB. The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation. Genes & Development. 29: 785-90. PMID 25838500 DOI: 10.1101/gad.257675.114  1
2014 Nikolov DB, Xu K, Himanen JP. Homotypic receptor-receptor interactions regulating Eph signaling. Cell Adhesion & Migration. 8: 360-5. PMID 25530219 DOI: 10.4161/19336918.2014.971684  0.68
2014 Goldgur Y, Susi P, Karelehto E, Sanmark H, Lamminmäki U, Oricchio E, Wendel HG, Nikolov DB, Himanen JP. Generation and characterization of a single-chain anti-EphA2 antibody. Growth Factors (Chur, Switzerland). 32: 214-22. PMID 25494541 DOI: 10.3109/08977194.2014.983225  0.68
2014 Saha N, Kolev M, Nikolov DB. Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface. Neuroscience Research. 87: 1-7. PMID 24956133 DOI: 10.1016/j.neures.2014.06.003  0.32
2014 Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB. Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science (New York, N.Y.). 344: 1275-9. PMID 24876346 DOI: 10.1126/science.1255149  1
2014 Barton WA, Dalton AC, Seegar TCM, Himanen JP, Nikolov DB. Tie2 and Eph receptor tyrosine kinase activation and signaling Cold Spring Harbor Perspectives in Biology. 6. PMID 24478383 DOI: 10.1101/cshperspect.a009142  1
2013 Xu K, Rockx B, Xie Y, DeBuysscher BL, Fusco DL, Zhu Z, Chan YP, Xu Y, Luu T, Cer RZ, Feldmann H, Mokashi V, Dimitrov DS, Bishop-Lilly KA, Broder CC, ... Nikolov DB, et al. Crystal structure of the Hendra virus attachment G glycoprotein bound to a potent cross-reactive neutralizing human monoclonal antibody. Plos Pathogens. 9: e1003684. PMID 24130486 DOI: 10.1371/journal.ppat.1003684  1
2013 Paavilainen S, Grandy D, Karelehto E, Chang E, Susi P, Erdjument-Bromage H, Nikolov D, Himanen J. High-level expression of a full-length Eph receptor. Protein Expression and Purification. 92: 112-8. PMID 24036371 DOI: 10.1016/j.pep.2013.08.016  0.6
2013 Xu K, Tzvetkova-Robev D, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB. Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proceedings of the National Academy of Sciences of the United States of America. 110: 14634-9. PMID 23959867 DOI: 10.1073/pnas.1311000110  0.68
2013 Xu K, Xu Y, Rajashankar KR, Robev D, Nikolov DB. Crystal structures of Lgr4 and its complex with R-spondin1. Structure (London, England : 1993). 21: 1683-9. PMID 23891289 DOI: 10.1016/j.str.2013.07.001  0.68
2013 Broder CC, Xu K, Nikolov DB, Zhu Z, Dimitrov DS, Middleton D, Pallister J, Geisbert TW, Bossart KN, Wang LF. A treatment for and vaccine against the deadly Hendra and Nipah viruses. Antiviral Research. 100: 8-13. PMID 23838047 DOI: 10.1016/j.antiviral.2013.06.012  1
2013 Ferluga S, Hantgan R, Goldgur Y, Himanen JP, Nikolov DB, Debinski W. Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase. The Journal of Biological Chemistry. 288: 18448-57. PMID 23661698 DOI: 10.1074/jbc.M113.464008  1
2013 Nikolov DB, Xu K, Himanen JP. Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation. Biochimica Et Biophysica Acta. 1834: 2160-5. PMID 23628727 DOI: 10.1016/j.bbapap.2013.04.020  0.68
2013 Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA. Structural basis for angiopoietin-1-mediated signaling initiation. Proceedings of the National Academy of Sciences of the United States of America. 110: 7205-10. PMID 23592718 DOI: 10.1073/pnas.1216890110  1
2013 Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, Van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling Faseb Journal. 27: 437-445. PMID 23070608 DOI: 10.1096/fj.12-20689  1
2012 Xu K, Chan YP, Rajashankar KR, Khetawat D, Yan L, Kolev MV, Broder CC, Nikolov DB. New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2. Plos One. 7: e48742. PMID 23144952 DOI: 10.1371/journal.pone.0048742  1
2012 Atapattu L, Saha N, Llerena C, Vail ME, Scott AM, Nikolov DB, Lackmann M, Janes PW. Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function. Journal of Cell Science. 125: 6084-93. PMID 23108669 DOI: 10.1242/jcs.112631  0.32
2012 Chan YP, Lu M, Dutta S, Yan L, Barr J, Flora M, Feng YR, Xu K, Nikolov DB, Wang LF, Skiniotis G, Broder CC. Biochemical, conformational, and immunogenic analysis of soluble trimeric forms of henipavirus fusion glycoproteins. Journal of Virology. 86: 11457-71. PMID 22915804 DOI: 10.1128/JVI.01318-12  1
2012 Broder CC, Geisbert TW, Xu K, Nikolov DB, Wang LF, Middleton D, Pallister J, Bossart KN. Immunization strategies against henipaviruses. Current Topics in Microbiology and Immunology. 359: 197-223. PMID 22481140 DOI: 10.1007/82_2012_213  1
2012 Steffen DL, Xu K, Nikolov DB, Broder CC. Henipavirus mediated membrane fusion, virus entry and targeted therapeutics. Viruses. 4: 280-308. PMID 22470837 DOI: 10.3390/v4020280  1
2012 Xu K, Broder CC, Nikolov DB. Ephrin-B2 and ephrin-B3 as functional henipavirus receptors. Seminars in Cell & Developmental Biology. 23: 116-23. PMID 22227101 DOI: 10.1016/j.semcdb.2011.12.005  1
2012 Colgrave ML, Snelling HJ, Shiell BJ, Feng YR, Chan YP, Bossart KN, Xu K, Nikolov DB, Broder CC, Michalski WP. Site occupancy and glycan compositional analysis of two soluble recombinant forms of the attachment glycoprotein of Hendra virus. Glycobiology. 22: 572-84. PMID 22171062 DOI: 10.1093/glycob/cwr180  1
2011 Saha N, Kolev MV, Semavina M, Himanen J, Nikolov DB. Ganglioside mediate the interaction between Nogo receptor 1 and LINGO-1. Biochemical and Biophysical Research Communications. 413: 92-7. PMID 21872576 DOI: 10.1016/j.bbrc.2011.08.060  0.56
2011 Singla N, Erdjument-Bromage H, Himanen JP, Muir TW, Nikolov DB. A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation. Chemistry & Biology. 18: 361-71. PMID 21439481 DOI: 10.1016/j.chembiol.2011.01.011  1
2011 Semavina M, Saha N, Kolev MV, Goldgur Y, Giger RJ, Himanen JP, Nikolov DB. Crystal structure of the Nogo-receptor-2. Protein Science : a Publication of the Protein Society. 20: 684-9. PMID 21308849 DOI: 10.1002/pro.597  1
2010 Singla N, Goldgur Y, Xu K, Paavilainen S, Nikolov DB, Himanen JP. Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations. Biochemical and Biophysical Research Communications. 399: 555-9. PMID 20678482 DOI: 10.1016/j.bbrc.2010.07.109  0.68
2010 Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proceedings of the National Academy of Sciences of the United States of America. 107: 10860-5. PMID 20505120 DOI: 10.1073/pnas.1004148107  1
2010 Seegar TC, Eller B, Tzvetkova-Robev D, Kolev MV, Henderson SC, Nikolov DB, Barton WA. Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands. Molecular Cell. 37: 643-55. PMID 20227369 DOI: 10.1016/j.molcel.2010.02.007  1
2009 Lesner A, Shilpi R, Ivanova A, Gawinowicz MA, Lesniak J, Nikolov D, Simm M. Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity. Biochemical and Biophysical Research Communications. 389: 284-9. PMID 19720052 DOI: 10.1016/j.bbrc.2009.08.140  0.72
2009 Himanen JP, Goldgur Y, Miao H, Myshkin E, Guo H, Buck M, Nguyen M, Rajashankar KR, Wang B, Nikolov DB. Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. Embo Reports. 10: 722-8. PMID 19525919 DOI: 10.1038/embor.2009.91  1
2009 Goldgur Y, Paavilainen S, Nikolov D, Himanen JP. Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 71-4. PMID 19193989 DOI: 10.1107/S1744309108043078  1
2008 Xu K, Rajashankar KR, Chan YP, Himanen JP, Broder CC, Nikolov DB. Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3. Proceedings of the National Academy of Sciences of the United States of America. 105: 9953-8. PMID 18632560 DOI: 10.1073/pnas.0804797105  1
2008 Singla N, Himanen JP, Muir TW, Nikolov DB. Toward the semisynthesis of multidomain transmembrane receptors: modification of Eph tyrosine kinases. Protein Science : a Publication of the Protein Society. 17: 1740-7. PMID 18628240 DOI: 10.1110/ps.035659.108  1
2007 Himanen JP, Saha N, Nikolov DB. Cell-cell signaling via Eph receptors and ephrins. Current Opinion in Cell Biology. 19: 534-42. PMID 17928214 DOI: 10.1016/j.ceb.2007.08.004  1
2007 Nikolov D, Li C, Lackmann M, Jeffrey P, Himanen J. Crystal structure of the human ephrin-A5 ectodomain. Protein Science : a Publication of the Protein Society. 16: 996-1000. PMID 17400922 DOI: 10.1110/ps.062665807  1
2007 Pabbisetty KB, Yue X, Li C, Himanen JP, Zhou R, Nikolov DB, Hu L. Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay. Protein Science : a Publication of the Protein Society. 16: 355-61. PMID 17322526 DOI: 10.1110/ps.062608807  0.68
2006 Barton WA, Tzvetkova-Robev D, Erdjument-Bromage H, Tempst P, Nikolov DB. Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells. Protein Science : a Publication of the Protein Society. 15: 2008-13. PMID 16823037 DOI: 10.1110/ps.062244206  1
2006 Barton WA, Tzvetkova-Robev D, Miranda EP, Kolev MV, Rajashankar KR, Himanen JP, Nikolov DB. Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex. Nature Structural & Molecular Biology. 13: 524-32. PMID 16732286 DOI: 10.1038/nsmb1101  1
2005 Janes PW, Saha N, Barton WA, Kolev MV, Wimmer-Kleikamp SH, Nievergall E, Blobel CP, Himanen JP, Lackmann M, Nikolov DB. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell. 123: 291-304. PMID 16239146 DOI: 10.1016/j.cell.2005.08.014  1
2005 Nikolov DB, Li C, Barton WA, Himanen JP. Crystal structure of the ephrin-B1 ectodomain: implications for receptor recognition and signaling. Biochemistry. 44: 10947-53. PMID 16101278 DOI: 10.1021/bi050789w  1
2005 Day B, To C, Himanen JP, Smith FM, Nikolov DB, Boyd AW, Lackmann M. Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. The Journal of Biological Chemistry. 280: 26526-32. PMID 15901737 DOI: 10.1074/jbc.M504972200  1
2005 Barton WA, Tzvetkova D, Nikolov DB. Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition. Structure (London, England : 1993). 13: 825-32. PMID 15893672 DOI: 10.1016/j.str.2005.03.009  1
2004 Lesner A, Kartvelishvili A, Lesniak J, Nikolov D, Kartvelishvili M, Trillo-Pazos G, Zablotna E, Simm M. Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1. Biochemistry. 43: 16203-11. PMID 15610014 DOI: 10.1021/bi0492758  0.72
2004 Barton WA, Himanen JP, Antipenko A, Nikolov DB. Structures of axon guidance molecules and their neuronal receptors. Advances in Protein Chemistry. 68: 65-106. PMID 15500859 DOI: 10.1016/S0065-3233(04)68003-X  1
2004 Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, Nikolov DB. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nature Neuroscience. 7: 501-9. PMID 15107857 DOI: 10.1038/nn1237  1
2004 Thorson JS, Barton WA, Hoffmeister D, Albermann C, Nikolov DB. Structure-based enzyme engineering and its impact on in vitro glycorandomization. Chembiochem : a European Journal of Chemical Biology. 5: 16-25. PMID 14695508 DOI: 10.1002/cbic.200300620  1
2003 Coyle JE, Nikolov DB. GABARAP: lessons for synaptogenesis. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 9: 205-16. PMID 15065816 DOI: 10.1177/1073858403009003013  1
2003 Lesniak J, Barton WA, Nikolov DB. Structural and functional features of the Escherichia coli hydroperoxide resistance protein OsmC. Protein Science : a Publication of the Protein Society. 12: 2838-43. PMID 14627744 DOI: 10.1110/ps.03375603  1
2003 Antipenko A, Himanen JP, van Leyen K, Nardi-Dei V, Lesniak J, Barton WA, Rajashankar KR, Lu M, Hoemme C, Püschel AW, Nikolov DB. Structure of the semaphorin-3A receptor binding module. Neuron. 39: 589-98. PMID 12925274 DOI: 10.1016/S0896-6273(03)00502-6  1
2003 Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. The Embo Journal. 22: 3291-302. PMID 12839991 DOI: 10.1093/emboj/cdg325  1
2003 Albermann C, Soriano A, Jiang J, Vollmer H, Biggins JB, Barton WA, Lesniak J, Nikolov DB, Thorson JS. Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization. Organic Letters. 5: 933-6. PMID 12633109 DOI: 10.1021/ol0341086  1
2003 Himanen JP, Nikolov DB. Eph signaling: a structural view. Trends in Neurosciences. 26: 46-51. PMID 12495863 DOI: 10.1016/S0166-2236(02)00005-X  1
2003 Himanen JP, Nikolov DB. Eph receptors and ephrins. The International Journal of Biochemistry & Cell Biology. 35: 130-4. PMID 12479863 DOI: 10.1016/S1357-2725(02)00096-1  1
2002 Lesniak J, Barton WA, Nikolov DB. Structural and functional characterization of the Pseudomonas hydroperoxide resistance protein Ohr. The Embo Journal. 21: 6649-59. PMID 12485986 DOI: 10.1093/emboj/cdf670  1
2002 Barton WA, Biggins JB, Jiang J, Thorson JS, Nikolov DB. Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering. Proceedings of the National Academy of Sciences of the United States of America. 99: 13397-402. PMID 12374866 DOI: 10.1073/pnas.192468299  1
2002 Himanen JP, Nikolov DB. Purification, crystallization and preliminary characterization of an Eph-B2/ephrin-B2 complex. Acta Crystallographica. Section D, Biological Crystallography. 58: 533-5. PMID 11856847 DOI: 10.1107/S0907444902000264  1
2002 Coyle JE, Qamar S, Rajashankar KR, Nikolov DB. Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding. Neuron. 33: 63-74. PMID 11779480  0.68
2001 Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB. Crystal structure of an Eph receptor-ephrin complex. Nature. 414: 933-8. PMID 11780069 DOI: 10.1038/414933a  1
2001 Barton WA, Lesniak J, Biggins JB, Jeffrey PD, Jiang J, Rajashankar KR, Thorson JS, Nikolov DB. Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization. Nature Structural Biology. 8: 545-51. PMID 11373625 DOI: 10.1038/88618  1
1998 Himanen JP, Henkemeyer M, Nikolov DB. Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2. Nature. 396: 486-91. PMID 9853759 DOI: 10.1038/24904  1
1997 Nikolov DB, Burley SK. RNA polymerase II transcription initiation: A structural view Proceedings of the National Academy of Sciences of the United States of America. 94: 15-22. PMID 8990153 DOI: 10.1073/pnas.94.1.15  1
1994 Nikolov DB, Burley SK. 2.1 Å resolution refined structure of a tata box-binding protein (TBP) Nature Structural Biology. 1: 621-637. PMID 7634102 DOI: 10.1038/nsb0994-621  1
1993 Kim JL, Nikolov DB, Burley SK. Co-crystal structure of TBP recognizing the minor groove of a TATA element. Nature. 365: 520-7. PMID 8413605 DOI: 10.1038/365520a0  1
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