George K. Michalopoulos - Publications

University of Pittsburgh, Pittsburgh, PA, United States 
Pathology, Biochemistry

251 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Martucci NJ, Stoops J, Bowen W, Orr A, Cotner MC, Michalopoulos GK, Bhushan B, Mars WM. A novel role for the phosphatidylinositol-4,5-bisphosphate 3-kinase delta isoform in hepatocellular proliferation. The American Journal of Pathology. PMID 38705383 DOI: 10.1016/j.ajpath.2024.03.016  0.317
2022 Koral K, Bhushan B, Orr A, Stoops J, Bowen WC, Copeland MA, Locker J, Mars WM, Michalopoulos GK. Lymphocyte specific protein 1 suppresses xenobiotic-induced CAR and subsequent YAP activated hepatocyte proliferation. The American Journal of Pathology. PMID 35390317 DOI: 10.1016/j.ajpath.2022.03.010  0.332
2021 Molina LM, Zhu J, Li Q, Pradhan-Sundd T, Krutsenko Y, Sayed K, Jenkins N, Vats R, Bhushan B, Ko S, Hu S, Poddar M, Singh S, Tao J, Sundd P, ... ... Michalopoulos G, et al. Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors. Cell Reports. 36: 109310. PMID 34233187 DOI: 10.1016/j.celrep.2021.109310  0.319
2021 Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, ... ... Michalopoulos GK, et al. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. PMID 33930309 DOI: 10.1016/j.ccell.2021.03.012  0.317
2021 Michalopoulos GK. Novel insights into liver homeostasis and regeneration. Nature Reviews. Gastroenterology & Hepatology. PMID 33911225 DOI: 10.1038/s41575-021-00454-0  0.309
2021 Martucci NJ, Michalopoulos GK, Mars WM. Integrin Linked Kinase (ILK) and its Role in Liver Pathobiology. Gene Expression. PMID 33482930 DOI: 10.3727/105221621X16113475275710  0.317
2020 Bhushan B, Molina L, Koral K, Stoops JW, Mars WM, Banerjee S, Orr A, Paranjpe S, Monga SP, Locker J, Michalopoulos GK. Yap is crucial for CAR-driven hepatocyte proliferation, but not for induction of drug metabolism genes in mice. Hepatology (Baltimore, Md.). PMID 32794202 DOI: 10.1002/Hep.31521  0.377
2020 Michalopoulos GK, Bhushan B. Liver regeneration: biological and pathological mechanisms and implications. Nature Reviews. Gastroenterology & Hepatology. PMID 32764740 DOI: 10.1038/S41575-020-0342-4  0.445
2020 Palliyaguru DL, Yang L, Chartoumpekis DV, Wendell SG, Fazzari M, Skoko JJ, Liao Y, Oesterreich S, Michalopoulos GK, Kensler TW. Sulforaphane Diminishes the Formation of Mammary Tumors in Rats Exposed to 17β-Estradiol. Nutrients. 12. PMID 32751496 DOI: 10.3390/Nu12082282  0.322
2020 Florentino RM, Fraunhoffer NA, Morita K, Takeishi K, Ostrowska A, Achreja A, Animasahun O, Haep N, Arazov S, Agarwal N, Collin de l'Hortet A, Guzman-Lepe J, Tafaleng EN, Mukherjee A, Troy K, ... ... Michalopoulos GK, et al. Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans. Hepatology Communications. 4: 859-875. PMID 32490322 DOI: 10.1002/hep4.1505  0.326
2020 Xue Y, Bhushan B, Mars WM, Bowen W, Tao J, Orr A, Stoops J, Yu Y, Luo J, Duncan A, Michalopoulos GK. p-Ezrin (Thr567) regulates Hippo pathway and Yap in liver. The American Journal of Pathology. PMID 32289287 DOI: 10.1016/J.Ajpath.2020.03.014  0.4
2020 Bhushan B, Michalopoulos GK. Role of epidermal growth factor receptor in liver injury and lipid metabolism: Emerging new roles for an old receptor. Chemico-Biological Interactions. 324: 109090. PMID 32283070 DOI: 10.1016/J.Cbi.2020.109090  0.43
2020 Xue Y, Bhushan B, Mars WM, Bowen W, Tao J, Orr A, Stoops J, Yu Y, Luo J, Duncan A, Michalopoulos GK. p‐Ezrin (Thr567) regulates Hippo pathway and Yap in liver The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.08976  0.41
2020 Bhushan B, Koral K, Stoops JW, Mars WM, Apte UM, Michalopoulos GK. Hepatic deletion of MET aggravates acetaminophen hepatotoxicity and impairs liver regeneration in mice The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05879  0.397
2020 Koral K, Bhushan B, Stoops J, Orr A, Mars W, Michalopoulos G. Lymphocyte Specific Protein‐1 suppresses TCPOBOP induced hepatocellular proliferation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05213  0.311
2019 Bhushan B, Banerjee S, Paranjpe S, Koral K, Mars WM, Stoops JW, Orr A, Bowen WC, Locker J, Michalopoulos GK. Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Non-alcoholic Fatty Liver Disease in Murine Fast-food Diet Model. Hepatology (Baltimore, Md.). PMID 31063640 DOI: 10.1002/Hep.30696  0.379
2019 Yu Y, Tsung A, Liu S, Nalesnick M, Geller D, Michalopoulos G, Luo J. Detection of fusion transcripts in the serum samples of patients with hepatocellular carcinoma Oncotarget. 10: 3352-3360. DOI: 10.18632/Oncotarget.26918  0.323
2018 Koral K, Haynes M, Bowen WC, Orr A, Mars W, Michalopoulos GK. Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation. The American Journal of Pathology. 188: 2074-2086. PMID 30126548 DOI: 10.1016/J.Ajpath.2018.06.005  0.409
2018 Tsagianni A, Mars WM, Bhushan B, Bowen WC, Orr A, Stoops J, Paranjpe S, Tseng GC, Liu S, Michalopoulos GK. Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor (EGFR) Signaling Causes Liver Failure in Normal Mice. The American Journal of Pathology. PMID 30031724 DOI: 10.1016/J.Ajpath.2018.06.009  0.455
2018 Michalopoulos GK. The Regenerative Altruism of Hepatocytes and Cholangiocytes. Cell Stem Cell. 23: 11-12. PMID 29979985 DOI: 10.1016/J.Stem.2018.06.006  0.361
2018 Bhushan B, Stoops JW, Mars WM, Orr A, Bowen WC, Paranjpe S, Michalopoulos GK. TCPOBOP-induced hepatomegaly & hepatocyte proliferation is attenuated by combined disruption of MET & EGFR signaling. Hepatology (Baltimore, Md.). PMID 29888801 DOI: 10.1002/Hep.30109  0.418
2018 Yokota S, Ono Y, Nakao T, Zhang P, Michalopoulos GK, Khan Z. Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis. Journal of Visualized Experiments : Jove. PMID 29658929 DOI: 10.3791/56930  0.601
2017 Doffou M, Adams G, Bowen WC, Paranjpe S, Parihar HS, Nguyen H, Michalopoulos GK, Bhave V. Oct4 is crucial for transdifferentiation of hepatocytes to biliary epithelial cells in an in vitro organoid culture model. Gene Expression. PMID 29212575 DOI: 10.3727/105221617X15124876321401  0.391
2017 Kader M, El-Azher M, Vorhauer J, Kode BB, Wells JZ, Stolz D, Michalopoulos G, Wells A, Scott M, Ismail N. MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. Plos Pathogens. 13: e1006644. PMID 29049365 DOI: 10.1371/Journal.Ppat.1006644  0.354
2017 Khan Z, Orr A, Michalopoulos GK, Ranganathan S. Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease. Pediatric and Developmental Pathology : the Official Journal of the Society For Pediatric Pathology and the Paediatric Pathology Society. 20: 16-27. PMID 28276299 DOI: 10.1177/1093526616686244  0.615
2017 Chen ZH, Yu YP, Tao J, Liu S, Tseng G, Nalesnik M, Hamilton R, Bhargava R, Nelson JB, Pennathur A, Monga SP, Luketich JD, Michalopoulos GK, Luo JH. MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. Gastroenterology. PMID 28245430 DOI: 10.1053/J.Gastro.2016.12.036  0.403
2016 Michalopoulos GK. Hepatostat: Liver regeneration and normal liver tissue maintenance. Hepatology (Baltimore, Md.). PMID 27997988 DOI: 10.1002/Hep.28988  0.438
2016 Khan Z, Yokota S, Ono Y, Bell AW, Stolz DB, Michalopoulos GK. BILE DUCT LIGATION INDUCES ATZ GLOBULE CLEARANCE IN A MOUSE MODEL OF ALPHA-1 ANTITRYPSIN DEFICIENCY. Gene Expression. PMID 27543967 DOI: 10.3727/105221616X692991  0.562
2016 Paranjpe S, Bowen WC, Mars WM, Orr A, Haynes MM, DeFrances MC, Liu S, Tseng GC, Tsagianni A, Michalopoulos GK. Combined systemic elimination of MET and EGFR signaling completely abolishes liver regeneration and leads to liver decompensation. Hepatology (Baltimore, Md.). PMID 27397846 DOI: 10.1002/Hep.28721  0.433
2016 Yu C, Yan S, Khambu B, Chen X, Dong Z, Luo J, Michalopoulos GK, Wu S, Yin XM. Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. Plos One. 11: e0155211. PMID 27196317 DOI: 10.1371/Journal.Pone.0155211  0.306
2016 Bhushan B, Michalopoulos G, Apte U, Edwards G, Desai A. Liver-specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration after Acetaminophen Overdose. Gene Expression. PMID 27125733 DOI: 10.3727/105221616X691578  0.426
2016 Khan Z, Orr AV, Michalopoulos GK, Ranganathan S. IMMUNOHISTOCHEMICAL ANALYSIS OF THE STEM CELL MARKER LGR5 IN PEDIATRIC LIVER DISEASE. Pediatric and Developmental Pathology : the Official Journal of the Society For Pediatric Pathology and the Paediatric Pathology Society. PMID 27019151 DOI: 10.2350/15-07-1668-Oa.1  0.629
2015 Michalopoulos GK, Khan Z. Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease. Gastroenterology. 149: 876-82. PMID 26278502 DOI: 10.1053/J.Gastro.2015.08.004  0.619
2015 Kang LI, Isse K, Koral K, Bowen WC, Muratoglu S, Strickland DK, Michalopoulos GK, Mars WM. Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1. Laboratory Investigation; a Journal of Technical Methods and Pathology. 95: 1117-29. PMID 26237273 DOI: 10.1038/Labinvest.2015.94  0.314
2015 Xue Y, Michalopoulos G. Tregs: A Therapeutic Target for the Treatment of Portal Fibrosis? Digestive Diseases and Sciences. 60: 1878-80. PMID 25972149 DOI: 10.1007/S10620-015-3687-8  0.315
2015 Koral K, Paranjpe S, Bowen WC, Mars W, Luo J, Michalopoulos GK. Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma. Hepatology (Baltimore, Md.). 61: 537-47. PMID 25234543 DOI: 10.1002/Hep.27444  0.325
2014 Bowen WC, Michalopoulos AW, Orr A, Ding MQ, Stolz DB, Michalopoulos GK. Development of a chemically defined medium and discovery of new mitogenic growth factors for mouse hepatocytes: mitogenic effects of FGF1/2 and PDGF. Plos One. 9: e95487. PMID 24743506 DOI: 10.1371/journal.pone.0095487  0.339
2014 Michalopoulos GK. Regenerative responses to liver injury European Journal of Medical Research. 19. DOI: 10.1186/2047-783X-19-S1-S1  0.476
2013 Donthamsetty S, Bhave VS, Mars WM, Bowen WC, Orr A, Haynes MM, Wu C, Michalopoulos GK. Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. Plos One. 8: e74625. PMID 24058607 DOI: 10.1371/Journal.Pone.0074625  0.322
2013 Michalopoulos GK. Principles of liver regeneration and growth homeostasis. Comprehensive Physiology. 3: 485-513. PMID 23720294 DOI: 10.1002/cphy.c120014  0.375
2013 Nejak-Bowen KN, Orr AV, Bowen WC, Michalopoulos GK. Gliotoxin-induced changes in rat liver regeneration after partial hepatectomy. Liver International : Official Journal of the International Association For the Study of the Liver. 33: 1044-55. PMID 23552057 DOI: 10.1111/Liv.12164  0.367
2013 Nejak-Bowen K, Orr A, Bowen WC, Michalopoulos GK. Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy. Plos One. 8: e59836. PMID 23527275 DOI: 10.1371/Journal.Pone.0059836  0.483
2013 Zhang XY, Tang LZ, Ren BG, Yu YP, Nelson J, Michalopoulos G, Luo JH. Interaction of MCM7 and RACK1 for activation of MCM7 and cell growth. The American Journal of Pathology. 182: 796-805. PMID 23313748 DOI: 10.1016/J.Ajpath.2012.11.020  0.344
2013 Isse K, Lesniak A, Grama K, Maier J, Specht S, Castillo-Rama M, Lunz J, Roysam B, Michalopoulos G, Demetris AJ. Preexisting epithelial diversity in normal human livers: a tissue-tethered cytometric analysis in portal/periportal epithelial cells. Hepatology (Baltimore, Md.). 57: 1632-43. PMID 23150208 DOI: 10.1002/Hep.26131  0.409
2013 Hattoum A, Rubin E, Orr A, Michalopoulos GK. Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failure. Human Pathology. 44: 743-9. PMID 23114924 DOI: 10.1016/J.Humpath.2012.07.018  0.462
2012 Kang LI, Mars WM, Michalopoulos GK. Signals and cells involved in regulating liver regeneration. Cells. 1: 1261-92. PMID 24710554 DOI: 10.3390/Cells1041261  0.46
2012 Nalesnik MA, Michalopoulos GK. Growth factor pathways in development and progression of hepatocellular carcinoma Frontiers in Bioscience - Scholar. 4: 1487-1515. PMID 22652888 DOI: 10.2741/S348  0.391
2012 Wang H, Luo K, Tan LZ, Ren BG, Gu LQ, Michalopoulos G, Luo JH, Yu YP. p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3. The Journal of Biological Chemistry. 287: 16890-902. PMID 22461624 DOI: 10.1074/Jbc.M111.322636  0.307
2012 Michalopoulos GK. Phenotypic fidelity (or not?) of epithelial cells in the liver. Hepatology (Baltimore, Md.). 55: 2024-7. PMID 22407729 DOI: 10.1002/hep.25703  0.323
2012 Nalesnik MA, Tseng G, Ding Y, Xiang GS, Zheng ZL, Yu Y, Marsh JW, Michalopoulos GK, Luo JH. Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation. The American Journal of Pathology. 180: 1495-508. PMID 22326833 DOI: 10.1016/J.Ajpath.2011.12.021  0.38
2012 Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ. A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology (Baltimore, Md.). 55: 609-21. PMID 21953681 DOI: 10.1002/Hep.24713  0.373
2012 Michalopoulos GK. Hepatocyte primary cultures : currently used systems and their applications for studies of hepatocyte growth and differentiation. Methods in Molecular Medicine. 18: 227-43. PMID 21370180 DOI: 10.1385/0-89603-516-6:227  0.457
2011 Donthamsetty S, Mars WM, Orr A, Wu C, Michalopoulos GK. Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice. Comparative Hepatology. 10: 11. PMID 22104495 DOI: 10.1186/1476-5926-10-11  0.352
2011 Bhave VS, Paranjpe S, Bowen WC, Donthamsetty S, Bell AW, Khillan JS, Michalopoulos GK. Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo. Hepatology (Baltimore, Md.). 54: 1360-70. PMID 21739467 DOI: 10.1002/Hep.24507  0.421
2011 Lin CW, Mars WM, Paranjpe S, Donthamsetty S, Bhave VS, Kang LI, Orr A, Bowen WC, Bell AW, Michalopoulos GK. Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice. Hepatology (Baltimore, Md.). 54: 620-30. PMID 21574168 DOI: 10.1002/Hep.24417  0.391
2011 Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, Stewart RE, Orr A, Wu C, Michalopoulos GK. Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene. Hepatology (Baltimore, Md.). 53: 587-95. PMID 21274879 DOI: 10.1002/Hep.24040  0.416
2011 Hammond JS, Gilbert TW, Howard D, Zaitoun A, Michalopoulos G, Shakesheff KM, Beckingham IJ, Badylak SF. Scaffolds containing growth factors and extracellular matrix induce hepatocyte proliferation and cell migration in normal and regenerating rat liver. Journal of Hepatology. 54: 279-87. PMID 21126791 DOI: 10.1016/J.Jhep.2010.06.040  0.45
2011 Michalopoulos GK. Liver regeneration: alternative epithelial pathways. The International Journal of Biochemistry & Cell Biology. 43: 173-9. PMID 19788929 DOI: 10.1016/J.Biocel.2009.09.014  0.455
2010 Limaye PB, Bowen WC, Orr A, Apte UM, Michalopoulos GK. Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation. Comparative Hepatology. 9: 9. PMID 21126359 DOI: 10.1186/1476-5926-9-9  0.44
2010 Liu B, Bell AW, Paranjpe S, Bowen WC, Khillan JS, Luo JH, Mars WM, Michalopoulos GK. Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice. Hepatology (Baltimore, Md.). 52: 1060-7. PMID 20812357 DOI: 10.1002/Hep.23794  0.588
2010 Han C, Bowen WC, Li G, Demetris AJ, Michalopoulos GK, Wu T. Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth. Hepatology (Baltimore, Md.). 52: 644-55. PMID 20683962 DOI: 10.1002/Hep.23703  0.445
2010 Zhu ZH, Yu YP, Zheng ZL, Song Y, Xiang GS, Nelson J, Michalopoulos G, Luo JH. Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death. The American Journal of Pathology. 177: 1176-86. PMID 20651226 DOI: 10.2353/Ajpath.2010.091026  0.338
2010 Ni HM, Baty CJ, Li N, Ding WX, Gao W, Li M, Chen X, Ma J, Michalopoulos GK, Yin XM. Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis. Hepatology (Baltimore, Md.). 52: 338-48. PMID 20578150 DOI: 10.1002/Hep.23672  0.322
2010 Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C, Maurice N, Mukherjee A, Goldbach C, Watkins S, Michalopoulos G, Perlmutter DH. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science (New York, N.Y.). 329: 229-32. PMID 20522742 DOI: 10.1126/Science.1190354  0.38
2010 Dawes J, Liu B, Mars W, Michalopoulos G, Khillan JS. Multiple ovarian transplants to rescue a transgenic line of mice. Lab Animal. 39: 191-3. PMID 20485359 DOI: 10.1038/Laban0610-191  0.421
2010 Han YC, Yu YP, Nelson J, Wu C, Wang H, Michalopoulos GK, Luo JH. Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression. Cancer Research. 70: 4375-84. PMID 20460506 DOI: 10.1158/0008-5472.Can-09-4403  0.35
2010 Paranjpe S, Bowen WC, Tseng GC, Luo JH, Orr A, Michalopoulos GK. RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats. The American Journal of Pathology. 176: 2669-81. PMID 20395437 DOI: 10.2353/Ajpath.2010.090605  0.47
2010 Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. The American Journal of Pathology. 176: 2-13. PMID 20019184 DOI: 10.2353/Ajpath.2010.090675  0.422
2010 Donthamsetty S, Bowen W, Mars W, Bhave V, Luo JH, Wu C, Hurd J, Orr A, Bell A, Michalopoulos G. Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration. Toxicological Sciences : An Official Journal of the Society of Toxicology. 113: 358-66. PMID 19920070 DOI: 10.1093/Toxsci/Kfp281  0.444
2009 Ullrich A, Stolz DB, Ellis EC, Strom SC, Michalopoulos GK, Hengstler JG, Runge D. Long term cultures of primary human hepatocytes as an alternative to drug testing in animals. Altex. 26: 295-302. PMID 20383475 DOI: 10.14573/Altex.2009.4.295  0.359
2009 Apte U, Gkretsi V, Bowen WC, Mars WM, Luo JH, Donthamsetty S, Orr A, Monga SP, Wu C, Michalopoulos GK. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology (Baltimore, Md.). 50: 844-51. PMID 19575460 DOI: 10.1002/Hep.23059  0.472
2009 Liu B, Paranjpe S, Bowen WC, Bell AW, Luo JH, Yu YP, Mars WM, Michalopoulos GK. Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation. The American Journal of Pathology. 175: 717-24. PMID 19574424 DOI: 10.2353/Ajpath.2009.081129  0.494
2008 Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK. Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (Baltimore, Md.). 48: 1932-41. PMID 18846549 DOI: 10.1002/Hep.22537  0.471
2008 Limaye PB, Alarcón G, Walls AL, Nalesnik MA, Michalopoulos GK, Demetris AJ, Ochoa ER. Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 865-72. PMID 18574450 DOI: 10.1038/Labinvest.2008.56  0.469
2008 Giannopoulou M, Dai C, Tan X, Wen X, Michalopoulos GK, Liu Y. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. The American Journal of Pathology. 173: 30-41. PMID 18502824 DOI: 10.2353/Ajpath.2008.070583  0.342
2008 Limaye PB, Bowen WC, Orr AV, Luo J, Tseng GC, Michalopoulos GK. Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium. Hepatology (Baltimore, Md.). 47: 1702-13. PMID 18398918 DOI: 10.1002/Hep.22221  0.443
2008 Tan X, Yuan Y, Zeng G, Apte U, Thompson MD, Cieply B, Stolz DB, Michalopoulos GK, Kaestner KH, Monga SP. Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology (Baltimore, Md.). 47: 1667-79. PMID 18393386 DOI: 10.1002/Hep.22225  0.348
2008 Han C, Bowen WC, Michalopoulos GK, Wu T. Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes. Journal of Cellular Physiology. 216: 486-97. PMID 18314882 DOI: 10.1002/Jcp.21420  0.397
2007 Zou C, Ma J, Wang X, Guo L, Zhu Z, Stoops J, Eaker AE, Johnson CJ, Strom S, Michalopoulos GK, DeFrances MC, Zarnegar R. Lack of Fas antagonism by Met in human fatty liver disease. Nature Medicine. 13: 1078-85. PMID 17704785 DOI: 10.1038/Nm1625  0.435
2007 Zhao Y, Difrancesca D, Wang X, Zarnegar R, Michalopoulos GK, Yin XM. Promotion of Fas-mediated apoptosis in Type II cells by high doses of hepatocyte growth factor bypasses the mitochondrial requirement. Journal of Cellular Physiology. 213: 556-63. PMID 17620325 DOI: 10.1002/Jcp.21136  0.3
2007 Michalopoulos GK. Liver regeneration. Journal of Cellular Physiology. 213: 286-300. PMID 17559071 DOI: 10.1002/jcp.21172  0.354
2007 Ren B, Yu YP, Tseng GC, Wu C, Chen K, Rao UN, Nelson J, Michalopoulos GK, Luo JH. Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma. Journal of the National Cancer Institute. 99: 868-80. PMID 17551147 DOI: 10.1093/Jnci/Djk199  0.338
2007 Gkretsi V, Mars WM, Bowen WC, Barua L, Yang Y, Guo L, St-Arnaud R, Dedhar S, Wu C, Michalopoulos GK. Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis. Hepatology (Baltimore, Md.). 45: 1025-34. PMID 17385211 DOI: 10.1002/Hep.21540  0.424
2007 Uppal H, Saini SP, Moschetta A, Mu Y, Zhou J, Gong H, Zhai Y, Ren S, Michalopoulos GK, Mangelsdorf DJ, Xie W. Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology (Baltimore, Md.). 45: 422-32. PMID 17256725 DOI: 10.1002/Hep.21494  0.323
2007 Gkretsi V, Bowen WC, Yang Y, Wu C, Michalopoulos GK. Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation. Biochemical and Biophysical Research Communications. 353: 638-43. PMID 17194454 DOI: 10.1016/J.Bbrc.2006.12.091  0.357
2007 Ochoa ER, Alarcon G, Demetris AJ, Nalesnik MA, Walls A, Michalopoulos GK. HNF‐Regulated Epithelial Differentiation in Human Liver Diseases The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A72-A  0.389
2007 Limaye PB, Bowen WC, Luo J, Michalopoulos GK. Role of HGF and EGF signaling in transdifferentiation of hepatocytes to biliary epithelium in organoid cultures The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A71-A  0.361
2007 Ullrich A, Stolz DB, Ellis EC, Strom SC, Michalopoulos GK, Berg C, Hengstler JG, Runge D. Acetaminophen induces a reversible switch from rough to smooth endoplasmatic reticulum and leads to glycogen degradation in human hepatocytes The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A189  0.337
2007 Paranjpe S, Bowen WC, Luo J, Nejak‐Bowen K, Michalopoulos GK. Abnormal Gene Expression Patterns In Regenerating liver of Rats Treated With c‐Met Silencing Constructs The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A188  0.379
2006 Tan X, Behari J, Cieply B, Michalopoulos GK, Monga SP. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology. 131: 1561-72. PMID 17101329 DOI: 10.1053/J.Gastro.2006.08.042  0.435
2006 Luo JH, Ren B, Keryanov S, Tseng GC, Rao UN, Monga SP, Strom S, Demetris AJ, Nalesnik M, Yu YP, Ranganathan S, Michalopoulos GK. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology (Baltimore, Md.). 44: 1012-24. PMID 17006932 DOI: 10.1002/Hep.21328  0.317
2006 Khan Z, Michalopoulos GK, Stolz DB. Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. The American Journal of Pathology. 169: 1251-69. PMID 17003483 DOI: 10.2353/Ajpath.2006.060360  0.611
2006 Michalopoulos GK. Flexible lineage specifications of adult hepatic cells, associated molecular pathways, and their relationship to liver cancer. Cell Transplantation. 15: S67-8. PMID 16826797 DOI: 10.3727/000000006783982377  0.403
2006 Bell AW, Michalopoulos GK. Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR. Hepatology (Baltimore, Md.). 44: 186-94. PMID 16799975 DOI: 10.1002/Hep.21234  0.383
2006 Xia JL, Dai C, Michalopoulos GK, Liu Y. Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation. The American Journal of Pathology. 168: 1500-12. PMID 16651617 DOI: 10.2353/Ajpath.2006.050747  0.48
2006 Giannopoulou M, Iszkula SC, Dai C, Tan X, Yang J, Michalopoulos GK, Liu Y. Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action. American Journal of Physiology. Renal Physiology. 290: F1234-40. PMID 16332928 DOI: 10.1152/Ajprenal.00388.2005  0.32
2006 Han C, Michalopoulos GK, Wu T. Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. Journal of Cellular Physiology. 207: 261-70. PMID 16331686 DOI: 10.1002/Jcp.20560  0.336
2005 Tan X, Apte U, Micsenyi A, Kotsagrelos E, Luo JH, Ranganathan S, Monga DK, Bell A, Michalopoulos GK, Monga SP. Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology. 129: 285-302. PMID 16012954 DOI: 10.1053/J.Gastro.2005.04.013  0.488
2005 Michalopoulos GK, DeFrances M. Liver regeneration. Advances in Biochemical Engineering/Biotechnology. 93: 101-34. PMID 15791946 DOI: 10.1007/b99968  0.363
2005 Michalopoulos GK, Barua L, Bowen WC. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology (Baltimore, Md.). 41: 535-44. PMID 15726663 DOI: 10.1002/Hep.20600  0.401
2005 Michalopoulos GK, Khan Z. Liver regeneration, growth factors, and amphiregulin. Gastroenterology. 128: 503-6. PMID 15685562 DOI: 10.1053/J.Gastro.2004.12.039  0.677
2004 Köhler C, Bell AW, Bowen WC, Monga SP, Fleig W, Michalopoulos GK. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology (Baltimore, Md.). 39: 1056-65. PMID 15057910 DOI: 10.1002/hep.20156  0.39
2004 Micsenyi A, Tan X, Sneddon T, Luo JH, Michalopoulos GK, Monga SP. Beta-catenin is temporally regulated during normal liver development. Gastroenterology. 126: 1134-46. PMID 15057752 DOI: 10.1053/J.Gastro.2003.12.047  0.404
2004 Hussain SZ, Sneddon T, Tan X, Micsenyi A, Michalopoulos GK, Monga SP. Wnt impacts growth and differentiation in ex vivo liver development. Experimental Cell Research. 292: 157-69. PMID 14720515 DOI: 10.1016/J.Yexcr.2003.08.020  0.459
2003 Leng J, Han C, Demetris AJ, Michalopoulos GK, Wu T. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology (Baltimore, Md.). 38: 756-68. PMID 12939602 DOI: 10.1053/Jhep.2003.50380  0.389
2003 Michalopoulos GK, Bowen WC, Mulè K, Luo J. HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Gene Expression. 11: 55-75. PMID 12837037 DOI: 10.3727/000000003108748964  0.462
2003 Han C, Demetris AJ, Michalopoulos GK, Zhan Q, Shelhamer JH, Wu T. PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway. Hepatology (Baltimore, Md.). 38: 167-77. PMID 12829999 DOI: 10.1053/Jhep.2003.50296  0.36
2003 Schoedel KE, Tyner VZ, Kim TH, Michalopoulos GK, Mars WM. HGF, MET, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 16: 14-21. PMID 12527708 DOI: 10.1097/01.Mp.0000043521.96995.Db  0.396
2003 Monga SP, Monga HK, Tan X, Mulé K, Pediaditakis P, Michalopoulos GK. Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology. 124: 202-16. PMID 12512043 DOI: 10.1053/Gast.2003.50000  0.746
2003 BELL A, MICHALOPOULOS G. 908 Molecular mechanisms of hepatic differentiation in-vitro Hepatology. 38: 596-596. DOI: 10.1016/S0270-9139(03)80947-3  0.327
2003 Sekhon SS, Sneddon T, Bowen W, Michalopoulos G, Monga SPS. Selective COX-2 inhibitor in liver cancer cells: Role and mechanism Gastroenterology. 124: A462. DOI: 10.1016/S0016-5085(03)82334-X  0.313
2003 Sekhon S, Tan X, Bowen W, Michalopoulos G, Monga SPS. Fibroblast growth factors promote hepatocyte stem cell renewal in embryonic liver cultures Gastroenterology. 124: A125. DOI: 10.1016/S0016-5085(03)80614-5  0.452
2003 Hussain S, Tan X, Michalopoulos G, Monga SPS. Wnt in liver development: Role in biliary cell survival and proliferation Gastroenterology. 124: A124. DOI: 10.1016/S0016-5085(03)80609-1  0.489
2002 Wu T, Han C, Lunz JG, Michalopoulos G, Shelhamer JH, Demetris AJ. Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells. Hepatology (Baltimore, Md.). 36: 363-73. PMID 12143044 DOI: 10.1053/Jhep.2002.34743  0.335
2002 Michalopoulos GK, Bowen WC, Mulè K, Lopez-Talavera JC, Mars W. Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology (Baltimore, Md.). 36: 278-83. PMID 12143035 DOI: 10.1053/Jhep.2002.34858  0.438
2002 Monga SP, Mars WM, Pediaditakis P, Bell A, Mulé K, Bowen WC, Wang X, Zarnegar R, Michalopoulos GK. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Research. 62: 2064-71. PMID 11929826  0.691
2002 Han C, Demetris AJ, Michalopoulos G, Shelhamer JH, Wu T. 85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 282: G586-97. PMID 11897617 DOI: 10.1152/Ajpgi.00305.2001  0.36
2002 Wang X, DeFrances MC, Dai Y, Pediaditakis P, Johnson C, Bell A, Michalopoulos GK, Zarnegar R. A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Molecular Cell. 9: 411-21. PMID 11864613 DOI: 10.1016/S1097-2765(02)00439-2  0.691
2002 Pediaditakis P, Monga SP, Mars WM, Michalopoulos GK. Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa. The Journal of Biological Chemistry. 277: 14109-15. PMID 11832492 DOI: 10.1074/Jbc.M112196200  0.713
2002 Koehler C, Bowen WC, Pediaditakis P, Monga SP, Walldorf J, Strom SC, Michalopoulos GK. Analyses of Jagged1 and Notch1 proteins in hepatocyte cultures and liver regeneration Journal of Hepatology. 36: 182-183. DOI: 10.1016/S0168-8278(02)80646-8  0.739
2001 Michalopoulos GK, Bowen WC, Mulè K, Stolz DB. Histological organization in hepatocyte organoid cultures. The American Journal of Pathology. 159: 1877-87. PMID 11696448 DOI: 10.1016/S0002-9440(10)63034-9  0.441
2001 Pediaditakis P, Lopez-Talavera JC, Petersen B, Monga SP, Michalopoulos GK. The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat. Hepatology (Baltimore, Md.). 34: 688-93. PMID 11584364 DOI: 10.1053/Jhep.2001.27811  0.744
2001 Kirimlioglu H, Dvorchick I, Ruppert K, Finkelstein S, Marsh JW, Iwatsuki S, Bonham A, Carr B, Nalesnik M, Michalopoulos G, Starzl T, Fung J, Demetris A. Hepatocellular carcinomas in native livers from patients treated with orthotopic liver transplantation: Biologic and therapeutic implications Hepatology. 34: 502-510. PMID 11526535 DOI: 10.1053/Jhep.2001.26633  0.35
2001 Monga SP, Pediaditakis P, Mule K, Stolz DB, Michalopoulos GK. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology (Baltimore, Md.). 33: 1098-109. PMID 11343237 DOI: 10.1053/Jhep.2001.23786  0.725
2001 Yang J, Chen S, Huang L, Michalopoulos GK, Liu Y. Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth Hepatology. 33: 848-859. PMID 11283849 DOI: 10.1053/Jhep.2001.23438  0.442
2001 Runge D, Jäger D, Schute G, Strom S, Michalopoulos G, Runge D. Low proliferative response of human hepatocytes to growth factors due to lack of cyclin D Journal of Hepatology. 34: 82. DOI: 10.1016/S0168-8278(01)81161-2  0.33
2001 Michalopoulos GK, Monga SP, Mars W, Bell A, Bowen WC, Mule K, Nejak K, Pediaditakis P. Hepatocyte growth factor induces wnt-1 independent nuclear translocation of beta-catenin through association of β-catenin and c-met in rat hepatocytes Gastroenterology. 120: A357. DOI: 10.1016/S0016-5085(08)81775-1  0.722
2001 Michalopoulos GK, Monga SP, Pediaditakis P, Stolz DB, Mule K. Changes in Wnt/β-catenin signaling during regulated growth in liver regeneration Gastroenterology. 120: A46. DOI: 10.1016/S0016-5085(08)80228-4  0.728
2000 Jo M, Stolz DB, Esplen JE, Dorko K, Michalopoulos GK, Strom SC. Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. The Journal of Biological Chemistry. 275: 8806-11. PMID 10722725 DOI: 10.1074/Jbc.275.12.8806  0.608
2000 Runge D, Runge DM, Jäger D, Lubecki KA, Beer Stolz D, Karathanasis S, Kietzmann T, Strom SC, Jungermann K, Fleig WE, Michalopoulos GK. Serum-free, long-term cultures of human hepatocytes: Maintenance of cell morphology, transcription factors, and liver-specific functions Biochemical and Biophysical Research Communications. 269: 46-53. PMID 10694475 DOI: 10.1006/Bbrc.2000.2215  0.429
1999 Runge DM, Runge D, Foth H, Strom SC, Michalopoulos GK. Stat 1α/1β, STAT 3 and STAT 5: Expression and association with c-MET and EGF-receptor in long-term cultures of human hepatocytes Biochemical and Biophysical Research Communications. 265: 376-381. PMID 10558875 DOI: 10.1006/Bbrc.1999.1681  0.338
1999 Stolz DB, Ross MA, Salem HM, Mars WM, Michalopoulos GK, Enomoto K. Cationic colloidal silica membrane perturbation as a means of examining changes at the sinusoidal surface during liver regeneration. The American Journal of Pathology. 155: 1487-98. PMID 10550305 DOI: 10.1016/S0002-9440(10)65464-8  0.43
1999 Stolz DB, Mars WM, Petersen BE, Kim TH, Michalopoulos GK. Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat Cancer Research. 59: 3954-3960. PMID 10463591  0.342
1999 Broten J, Michalopoulos G, Petersen B, Cruise J. Adrenergic stimulation of hepatocyte growth factor expression. Biochemical and Biophysical Research Communications. 262: 76-9. PMID 10448071 DOI: 10.1006/Bbrc.1999.1183  0.431
1999 Runge D, Runge DM, Daskalakis N, Lubecki KA, Bowen WC, Michalopoulos GK. Matrix-mediated changes in the expression of HNF-4alpha isoforms and in DNA-binding activity of ARP-1 in primary cultures of rat hepatocytes. Biochemical and Biophysical Research Communications. 259: 651-5. PMID 10364473 DOI: 10.1006/Bbrc.1999.0848  0.328
1999 Runge DM, Bowen WC, Katyal S, Runge D, Suski V, Michalopoulos GK. Expression of the human hepatocyte growth factor cDNA in primary cultures of rat hepatocytes. Biochemical and Biophysical Research Communications. 257: 199-205. PMID 10092533 DOI: 10.1006/bbrc.1998.9947  0.348
1999 Runge DM, Runge D, Dorko K, Pisarov LA, Leckel K, Kostrubsky VE, Thomas D, Strom SC, Michalopoulos GK. Epidermal growth factor- and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes Journal of Hepatology. 30: 265-274. PMID 10068107 DOI: 10.1016/S0168-8278(99)80073-7  0.301
1999 Bell A, Chen Q, DeFrances MC, Michalopoulos GK, Zarnegar R. The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice Oncogene. 18: 887-895. PMID 10023664 DOI: 10.1038/Sj.Onc.1202379  0.311
1999 Michalopoulos GK, Bowen WC, Zajac VF, Beer-Stolz D, Watkins S, Kostrubsky V, Strom SC. Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor. Hepatology (Baltimore, Md.). 29: 90-100. PMID 9862855 DOI: 10.1002/Hep.510290149  0.448
1998 Miyazaki M, Mars WM, Michalopoulos GK, Namba M. Dose-dependent biphasic effects of phenobarbital on growth and differentiation of primary culture rat hepatocytes. Journal of Gastroenterology and Hepatology. 13: S78-S82. PMID 28976694 DOI: 10.1111/Jgh.1998.13.S1.78  0.418
1998 Liu Z, Sakamoto T, Ezure T, Yokomuro S, Murase N, Michalopoulos G, Demetris AJ. Interleukin‐6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type i ductular reaction in mice: Interactions between the periductal inflammatory and stromal cells and the biliary epithelium Hepatology. 28: 1260-1268. PMID 9794910 DOI: 10.1002/Hep.510280514  0.386
1998 Runge D, Runge DM, Drenning SD, Bowen WC, Grandis JR, Michalopoulos GK. Growth and differentiation of rat hepatocytes: changes in transcription factors HNF-3, HNF-4, STAT-3, and STAT-5. Biochemical and Biophysical Research Communications. 250: 762-8. PMID 9784420 DOI: 10.1006/Bbrc.1998.9384  0.425
1998 Kim TH, Bowen WC, Stolz DB, Runge D, Mars WM, Michalopoulos GK. Differential expression and distribution of focal adhesion and cell adhesion molecules in rat hepatocyte differentiation. Experimental Cell Research. 244: 93-104. PMID 9770353 DOI: 10.1006/Excr.1998.4209  0.432
1998 Shima N, Stolz DB, Miyazaki M, Gohda E, Higashio K, Michalopoulos GK. Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor Journal of Cellular Physiology. 177: 130-136. PMID 9731753 DOI: 10.1002/(Sici)1097-4652(199810)177:1<130::Aid-Jcp14>3.0.Co;2-H  0.395
1998 Takeshita K, Bowen WC, Michalopoulos GK. Three-dimensional culture of hepatocytes in a continuously flowing medium. In Vitro Cellular & Developmental Biology. Animal. 34: 482-5. PMID 9661052 DOI: 10.1007/S11626-998-0082-1  0.391
1998 Miyazaki M, Mars WM, Runge D, Kim TH, Bowen WC, Michalopoulos GK. Phenobarbital suppresses growth and accelerates restoration of differentiation markers of primary culture rat hepatocytes in the chemically defined hepatocyte growth medium containing hepatocyte growth factor and epidermal growth factor. Experimental Cell Research. 241: 445-57. PMID 9637786 DOI: 10.1006/Excr.1998.4085  0.456
1998 Petersen BE, Zajac VF, Michalopoulos GK. Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats Hepatology. 27: 1030-1038. PMID 9537443 DOI: 10.1002/Hep.510270419  0.375
1998 Oshika E, Liu S, Singh G, Michalopoulos GK, Shinozuka H, Katyal SL. Antagonistic effects of dexamethasone and retinoic acid on rat lung morphogenesis. Pediatric Research. 43: 315-24. PMID 9505268 DOI: 10.1203/00006450-199803000-00002  0.311
1998 Oshika E, Liu S, Ung LP, Singh G, Shinozuka H, Michalopoulos GK, Katyal SL. Glucocorticoid-induced effects on pattern formation and epithelial cell differentiation in early embryonic rat lungs. Pediatric Research. 43: 305-14. PMID 9505267 DOI: 10.1203/00006450-199803000-00001  0.334
1998 Stolz DB, Michalopoulos GK. Differential modulation of hepatocyte growth factor-stimulated motility by transforming growth factor β1 on rat liver epithelial cells in vitro Journal of Cellular Physiology. 175: 30-40. PMID 9491778 DOI: 10.1002/(Sici)1097-4652(199804)175:1<30::Aid-Jcp4>3.0.Co;2-D  0.364
1998 Petersen BE, Goff JP, Greenberger JS, Michalopoulos GK. Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat Hepatology. 27: 433-445. PMID 9462642 DOI: 10.1002/Hep.510270218  0.395
1998 Miyazaki M, Mars WM, Michalopoulos GK, Namba M. Dose-dependent biphasic effects of phenobarbital on growth and differentiation of primary culture rat hepatocytes Journal of Gastroenterology and Hepatology (Australia). 13.  0.305
1997 Runge D, Runge DM, Bowen WC, Locker J, Michalopoulos GK. Matrix induced re-differentiation of cultured rat hepatocytes and changes of CCAAT/enhancer binding proteins. Biological Chemistry. 378: 873-81. PMID 9377484 DOI: 10.1515/Bchm.1997.378.8.873  0.382
1997 Rao UNM, Sonmez-Alpan E, Michalopoulos GK. Hepatocyte growth factor and c-MET in benign and malignant peripheral nerve sheath tumors Human Pathology. 28: 1066-1070. PMID 9308731 DOI: 10.1016/S0046-8177(97)90060-5  0.348
1997 Nakopoulou L, Vouriakou C, Papaliodi E, Lazaris AC, Stefanaski K, Michalopoulos G. Immunodetection of c-met-oncogene's protein product in renal cell neoplasia. Pathology Research and Practice. 193: 299-304. PMID 9258956 DOI: 10.1016/S0344-0338(97)80007-6  0.305
1997 Presnell SC, Stolz DB, Mars WM, Jo M, Michalopoulos GK, Strom SC. Modifications of the hepatocyte growth factor/c-met pathway by constitutive expression of transforming growth factor-alpha in rat liver epithelial cells. Molecular Carcinogenesis. 18: 244-55. PMID 9142219 DOI: 10.1002/(Sici)1098-2744(199704)18:4<244::Aid-Mc8>3.0.Co;2-D  0.628
1997 Stolz DB, Michalopoulos GK. Synergistic enhancement of EGF, but not HGF, stimulated hepatocyte motility by TGF-β1 in vitro Journal of Cellular Physiology. 170: 57-68. PMID 9012785 DOI: 10.1002/(Sici)1097-4652(199701)170:1<57::Aid-Jcp7>3.0.Co;2-K  0.39
1996 Goff JP, Shields DS, Petersen BE, Zajac VF, Michalopoulos GK, Greenberger JS. Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are the result of c-met receptor expression Stem Cells. 14: 592-602. PMID 8888500 DOI: 10.1002/Stem.140592  0.333
1996 Yamaguchi K, Nalesnik MA, Michalopoulos GK. Hepatocyte growth factor mRNA in human liver cirrhosis as evidenced by in situ hybrdization Scandinavian Journal of Gastroenterology. 31: 921-927. PMID 8888442 DOI: 10.3109/00365529609052003  0.448
1996 Liu ZZ, Cui S, Billiar TR, Dorko K, Halfter W, Geller DA, Michalopoulos G, Beger HG, Albina J, Nussler AK. Effects of hepatocellular mitogens on cytokine-induced nitric oxide synthesis in human hepatocytes. Journal of Leukocyte Biology. 60: 382-8. PMID 8830795 DOI: 10.1002/Jlb.60.3.382  0.403
1996 Shiratori M, Oshika E, Ung LP, Singh G, Shinozuka H, Warburton D, Michalopoulos G, Katyal SL. Keratinocyte growth factor and embryonic rat lung morphogenesis. American Journal of Respiratory Cell and Molecular Biology. 15: 328-38. PMID 8810636 DOI: 10.1165/Ajrcmb.15.3.8810636  0.356
1996 Block GD, Locker J, Bowen WC, Petersen BE, Katyal S, Strom SC, Riley T, Howard TA, Michalopoulos GK. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. The Journal of Cell Biology. 132: 1133-49. PMID 8601590 DOI: 10.1083/Jcb.132.6.1133  0.485
1996 Runge DM, Michalopoulos GK. HGF, EGF, and retrovirus-mediated gene transfer into cultured rat hepatocytes Faseb Journal. 10.  0.319
1996 Petersen BE, Zaiac VF, Michalopoulos GK. Hepatic oval call activation disrupted when bile duct destruction occurs following methylene dianiline exposure Faseb Journal. 10.  0.307
1995 Zarnegar R, Michalopoulos GK. The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis Journal of Cell Biology. 129: 1177-1180. PMID 7775566 DOI: 10.1083/Jcb.129.5.1177  0.33
1995 Mars WM, Liu ML, Kitson RP, Goldfarb RH, Gabauer MK, Michalopoulos GK. Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration Hepatology. 21: 1695-1701. PMID 7768515 DOI: 10.1002/Hep.1840210631  0.459
1995 Liu ML, Mars WM, Michalopoulos GK. Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine Carcinogenesis. 16: 841-843. PMID 7728965 DOI: 10.1093/Carcin/16.4.841  0.412
1995 Rauk PN, Surti U, Roberts JM, Michalopoulos G. Mitogenic effect of basic fibroblast growth factor and estradiol on cultured human myometrial and leiomyoma cells American Journal of Obstetrics and Gynecology. 173: 571-577. PMID 7645636 DOI: 10.1016/0002-9378(95)90284-8  0.389
1995 Shiratori M, Michalopoulos G, Shinozuka H, Singh G, Ogasawara H, Katyal SL. Hepatocyte growth factor stimulates DNA synthesis in alveolar epithelial type II cells in vitro. American Journal of Respiratory Cell and Molecular Biology. 12: 171-80. PMID 7532419 DOI: 10.1165/Ajrcmb.12.2.7532419  0.399
1994 Liu ML, Mars WM, Zarnegar R, Michalopoulos GK. Uptake and distribution of hepatocyte growth factor in normal and regenerating adult rat liver American Journal of Pathology. 144: 129-140. PMID 8291602  0.351
1994 Liu ML, Mars WM, Zarnegar R, Michalopoulos GK. Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-α in adult rat liver Hepatology. 19: 1521-1527. PMID 8188184 DOI: 10.1002/Hep.1840190630  0.441
1994 Liu Y, Bell AW, Michalopoulos GK, Zarnegar R. The mouse hepatocyte growth factor-encoding gene: structural organization and evolutionary conservation Gene. 144: 179-187. PMID 8039703 DOI: 10.1016/0378-1119(94)90376-X  0.302
1994 Stolz DB, Michalopoulos GK. Comparative effects of hepatocyte growth factor and epidermal growth factor on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytes Journal of Cellular Biochemistry. 55: 445-464. PMID 7962176 DOI: 10.1002/Jcb.240550405  0.406
1994 Petersen B, Yee CJ, Bowen W, Zarnegar R, Michalopoulos GK. Distinct morphological and mito-inhibitory effects induced by TGF-β1, HGF and EGF on mouse, rat and human hepatocytes Cell Biology and Toxicology. 10: 219-230. PMID 7895151 DOI: 10.1007/Bf00756762  0.373
1994 Matsumoto K, Fujii H, Michalopoulos G, Fung JJ, Demetris AJ. Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro Hepatology. 20: 376-382. DOI: 10.1002/Hep.1840200217  0.427
1993 Michalopoulos GK, Appasamy R. Metabolism of HGF-SF and its role in liver regeneration Exs. 65: 275-283. PMID 8422547  0.315
1993 Michalopoulos GK, Bowen W, Nussler AK, Becich MJ, Howard TA. Comparative analysis of mitogenic and morphogenic effects of HGF and EGF on rat and human hepatocytes maintained in collagen gels Journal of Cellular Physiology. 156: 443-452. PMID 8360254 DOI: 10.1002/Jcp.1041560303  0.423
1993 Yee CJ, Defrances MC, Bell A, Bowen W, Petersen B, Michalopoulos GK, Zarnegar R. Expression and characterization of biologically active human hepatocyte growth factor (HGF) by insect cells infected with HGF-recombinant baculovirus Biochemistry. 32: 7922-7931. PMID 8347597 DOI: 10.1021/Bi00082A013  0.418
1993 Liu Y, Michalopoulos GK, Zarnegar R. Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor Bba - Gene Structure and Expression. 1216: 299-303. PMID 8241272 DOI: 10.1016/0167-4781(93)90159-B  0.343
1993 Michalopoulos G. HGF and liver regeneration. Gastroenterologia Japonica. 36-9; discussion 53-. PMID 7683618 DOI: 10.1007/Bf02782887  0.428
1993 Lindroos P, Michalopoulos GK. Response of phenobarbital- and ciprofibrate-exposed hepatocytes to growth factors in type I collagen gels Carcinogenesis. 14: 731-735. PMID 7682481 DOI: 10.1093/Carcin/14.4.731  0.427
1992 Zarnegar R, Petersen B, DeFrances MC, Michalopoulos G. Localization of hepatocyte growth factor (HGF) gene on human chromosome 7. Genomics. 12: 147-50. PMID 1531136 DOI: 10.1016/0888-7543(92)90417-Q  0.325
1992 Baffy G, Yang L, Michalopoulos GK, Williamson JR. Hepatocyte growth factor induces calcium mobilization and inositol phosphate production in rat hepatocytes Journal of Cellular Physiology. 153: 332-339. PMID 1429853 DOI: 10.1002/Jcp.1041530213  0.306
1992 Wolf HK, Michalopoulos GK. Hepatocyte regeneration in acute fulminant and nonfulminant hepatitis: A study of proliferating cell nuclear antigen expression Hepatology. 15: 707-713. PMID 1372584 DOI: 10.1002/Hep.1840150426  0.427
1992 Lindroos P, Tsai WH, Zarnegar R, Michalopoulos GK. Plasma levels of hgf in rats treated with tumor promoters Carcinogenesis. 13: 139-141. PMID 1370768 DOI: 10.1093/Carcin/13.1.139  0.426
1992 Hernandez J, Zarnegar R, Michalopoulos GK. Characterization of the effects of human placental HGF on rat hepatocytes Journal of Cellular Physiology. 150: 116-121. PMID 1370501 DOI: 10.1002/Jcp.1041500116  0.438
1992 Defrances MC, Wolf HK, Michalopoulos GK, Zarnegar R. The presence of hepatocyte growth factor in the developing rat Development. 116: 387-395. PMID 1286614  0.323
1991 Skouteris GG, Michalopoulos GK. Synthesis and phosphorylation of an extracellular polypeptide reacting with anti-MYC antisera in primary rat hepatocyte cultures Biochemical and Biophysical Research Communications. 180: 631-637. PMID 1953733 DOI: 10.1016/S0006-291X(05)81112-X  0.383
1991 Francavilla A, Starzl TE, Porter K, Foglieni CS, Michalopoulos GK, Carrieri G, Trejo J, Azzarone A, Barone M, Zeng QH. Screening for candidate hepatic growth factors by selective portal infusion after canine Eck's fistula Hepatology. 14: 665-670. PMID 1916668 DOI: 10.1002/Hep.1840140415  0.375
1991 Wolf HK, Zarnegar R, Michalopoulos GK. Localization of hepatocyte growth factor in human and rat tissues: An immunohistochemical study Hepatology. 14: 488-494. PMID 1831438 DOI: 10.1002/Hep.1840140314  0.415
1991 Zarnegar R, DeFrances MC, Kost DP, Lindroos P, Michalopoulos GK. Expression of Hepatocyte Growth Factor mRNA in regenerating rat liver after partial hepatectomy Biochemical and Biophysical Research Communications. 177: 559-565. PMID 1828343 DOI: 10.1016/0006-291X(91)92020-K  0.485
1991 Kost DP, Michalopoulos GK. Effect of 2% dimethyl sulfoxide on the mitogenic properties of epidermal growth factor and hepatocyte growth factor in primary hepatocyte culture Journal of Cellular Physiology. 147: 274-280. PMID 1828251 DOI: 10.1002/Jcp.1041470212  0.422
1991 Michalopoulos GK, Zarnegar R, Houck K, Pediaditakis P. Hepatopoietins A and B and hepatocyte growth. Digestive Diseases and Sciences. 36: 681-6. PMID 1827065 DOI: 10.1007/Bf01297038  0.746
1991 Lindroos PM, Zarnegar R, Michalopoulos GK. Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration Hepatology. 13: 743-750. PMID 1826282  0.348
1991 Tsai WH, Zarnegar R, Michalopoulos GK. Long-term treatment with hepatic tumor promoters inhibits mitogenic responses of hepatocytes to acidic fibroblast growth factor and hepatocyte growth factor Cancer Letters. 59: 103-108. PMID 1715812 DOI: 10.1016/0304-3835(91)90173-F  0.449
1991 Tsai WH, Michalopoulos GK. Responsiveness of hepatocytes to epidermal growth factor, transforming growth factor-beta and norepinephrine during treatment with xenobiotic hepatic tumor promoters Cancer Letters. 57: 83-90. PMID 1709063 DOI: 10.1016/0304-3835(91)90067-R  0.381
1991 Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto Narsimhan CRP, Hartmann G, Zarnegar R, Michalopoulos GK, Birchmeier W, Comoglio PM. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor Embo Journal. 10: 2867-2878. PMID 1655405  0.31
1991 Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. The Embo Journal. 10: 2867-2878. DOI: 10.1002/J.1460-2075.1991.Tb07836.X  0.428
1990 Chan K, Kost DP, Michalopoulos G. Multiple sequential periods of DNA synthesis and quiescence in primary hepatocyte cultures maintained on the DMSO-EGF on/off protocol. Journal of Cellular Physiology. 141: 584-90. PMID 2592427 DOI: 10.1002/Jcp.1041410317  0.379
1990 Michalopoulos GK. Liver regeneration: Molecular mechanisms of growth control Faseb Journal. 4: 176-187. PMID 2404819 DOI: 10.1096/Fasebj.4.2.2404819  0.483
1990 Monteith DK, Michalopoulos G, Strom SC. Conjugation of chemical carcinogens by primary cultures of human hepatocytes Xenobiotica. 20: 753-763. PMID 2219959 DOI: 10.3109/00498259009046890  0.304
1990 Kost DP, Michalopoulos GK. Effect of epidermal growth factor on the expression of protooncogenes c-myc and c-Ha-ras in short-term primary hepatocyte culture Journal of Cellular Physiology. 144: 122-127. PMID 2195043 DOI: 10.1002/Jcp.1041440116  0.379
1990 Wolf HK, Burchette JL, Garcia JA, Michalopoulos G. Exocrine pancreatic tissue in human liver: a metaplastic process? The American Journal of Surgical Pathology. 14: 590-5. PMID 2186646 DOI: 10.1097/00000478-199006000-00011  0.349
1990 Zarnegar R, DeFrances MC, Oliver L, Michalopoulos G. Identification and partial characterization of receptor binding sites for HGF on rat hepatocytes. Biochemical and Biophysical Research Communications. 173: 1179-85. PMID 2148475 DOI: 10.1016/S0006-291X(05)80910-6  0.335
1990 Zarnegar R, Muga S, Rahija R, Michalopoulos G. Tissue distribution of hepatopoietin-A: a heparin-binding polypeptide growth factor for hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 87: 1252-6. PMID 2137248 DOI: 10.1073/Pnas.87.3.1252  0.386
1990 Monteith DK, Ding D, Chen YT, Michalopoulos G, Strom SC. Induction of cytochrome P1450 RNA and benzo[a]pyrene metabolism in primary human hepatocyte cultures with benzanthranene Toxicology and Applied Pharmacology. 105: 460-471. PMID 1700499 DOI: 10.1016/0041-008X(90)90149-O  0.324
1990 Houck KA, Zarnegar R, Muga SJ, Michalopoulos GK. Acidic fibroblast growth factor (HBGF-1) stimulates DNA synthesis in primary rat hepatocyte cultures Journal of Cellular Physiology. 143: 129-132. PMID 1690739 DOI: 10.1002/Jcp.1041430117  0.424
1989 Marselos M, Strom SC, Michalopoulos G. Enhancement of aldehyde dehydrogenase activity in human and rat hepatocyte cultures by 3-methylcholanthrene. Cell Biology and Toxicology. 2: 257-69. PMID 3267450 DOI: 10.1007/Bf00122694  0.37
1989 Houck KA, Michalopoulos GK. Altered responses of regenerating hepatocytes to norepinephrine and transforming growth factor type β Journal of Cellular Physiology. 141: 503-509. PMID 2574179 DOI: 10.1002/Jcp.1041410308  0.464
1989 Gebhardt R, Jirtle R, Moorman AF, Lamers WH, Michalopoulos G. Induction of glutamine synthetase and transient co-expression with carbamoylphosphate synthetase in hepatocytes transplanted into fat pads of syngeneic hosts. Histochemistry. 92: 337-42. PMID 2572574 DOI: 10.1007/Bf00500550  0.343
1989 Cruise JL, Muga SJ, Lee YS, Michalopoulos GK. Regulation of hepatocyte growth: Alpha-1 adrenergic receptor and ras p21 changes in liver regeneration Journal of Cellular Physiology. 140: 195-201. PMID 2545731 DOI: 10.1002/Jcp.1041400202  0.4
1989 Tsai WH, Cruise JL, Michalopoulos GK. Blockade of α-1 adrenergic receptor inhibits hepatic DNA synthesis stimulated by tumor promoters Carcinogenesis. 10: 73-78. PMID 2463115 DOI: 10.1093/Carcin/10.1.73  0.36
1988 Luetteke NC, Michalopoulos GK, Teixidó J, Gilmore R, Massagué J, Lee DC. Characterization of high molecular weight transforming growth factor α produced by rat hepatocellular carcinoma cells Biochemistry. 27: 6487-6494. PMID 3219349 DOI: 10.1021/Bi00417A043  0.37
1988 Monteith DK, Michalopoulos G, Strom SC. Metabolism of acetylaminofluorene in primary cultures of human hepatocytes: Dose-response over a four-log range Carcinogenesis. 9: 1835-1841. PMID 3168162 DOI: 10.1093/Carcin/9.10.1835  0.329
1988 Houck KA, Cruise JL, Michalopoulos G. Norepinephrine modulates the growth-inhibitory effect of transforming growth factor-beta in primary rat hepatocyte cultures. Journal of Cellular Physiology. 135: 551-5. PMID 3165094 DOI: 10.1002/Jcp.1041350327  0.411
1988 Cruise JL, Houck KA, Michalopoulos G. Early events in the regulation of hepatocyte DNA synthesis: the role of alpha-adrenergic stimulation. Scandinavian Journal of Gastroenterology. Supplement. 151: 19-30. PMID 2852400 DOI: 10.3109/00365528809095910  0.425
1987 Marselos M, Michalopoulos G. Phenobarbital enhances the aldehyde dehydrogenase activity of rat hepatocytes in vitro and in vivo. Acta Pharmacologica Et Toxicologica. 59: 403-9. PMID 3811968 DOI: 10.1111/J.1600-0773.1986.Tb00191.X  0.357
1987 Marselos M, Michalopoulos G. Changes in the pattern of aldehyde dehydrogenase activity in primary and metastatic adenocarcinomas of the human colon. Cancer Letters. 34: 27-37. PMID 3802067 DOI: 10.1016/0304-3835(87)90070-X  0.335
1987 Monteith DK, Novotny A, Michalopoulos G, Strom SC. Metabolism of benzo[a]pyrene in primary cultures of human hepatocytes: Dose-response over a four-log range Carcinogenesis. 8: 983-988. PMID 3594730 DOI: 10.1093/Carcin/8.7.983  0.304
1987 Michalopoulos GK, Eckl PM, Cruise JL, Novicki DL, Jirtle RL. Mechanisms of Rodent Liver Carcinogenesis Toxicology and Industrial Health. 3: 119-128. PMID 3303445 DOI: 10.1177/074823378700300209  0.347
1987 Eckl PM, Strom SC, Michalopoulos G, Jirtle RL. Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly and indirectly acting mutagens/carcinogens. Carcinogenesis. 8: 1077-83. PMID 3111742 DOI: 10.1093/Carcin/8.8.1077  0.31
1987 Marselos M, Strom SC, Michalopoulos G. Effect of phenobarbital and 3-methylcholanthrene on aldehyde dehydrogenase activity in cultures of HepG2 cells and normal human hepatocytes. Chemico-Biological Interactions. 62: 75-88. PMID 3034438 DOI: 10.1016/0009-2797(87)90080-9  0.343
1987 Rosenberg MR, Michalopoulos G. Kidney proximal tubular cells isolated by collagenase perfusion grow in defined media in the absence of growth factors. Journal of Cellular Physiology. 131: 107-13. PMID 2883190 DOI: 10.1002/Jcp.1041310116  0.327
1987 Cruise JL, Knechtle SJ, Bollinger RR, Kuhn C, Michalopoulos G. Alpha 1-adrenergic effects and liver regeneration. Hepatology (Baltimore, Md.). 7: 1189-94. PMID 2824312 DOI: 10.1002/Hep.1840070604  0.459
1986 Loury DJ, Smith-Oliver T, Strom S, Jirtle R, Michalopoulos G, Butterworth BE. Assessment of unscheduled and replicative DNA synthesis in hepatocytes treated in vivo and in vitro with unleaded gasoline or 2,2,4-trimethylpentane. Toxicology and Applied Pharmacology. 85: 11-23. PMID 3726884 DOI: 10.1016/0041-008X(86)90383-2  0.397
1986 Jirtle RL, Michalopoulos G. Enhancement of the clonability of adult parenchymal hepatocytes with the liver tumor promoter phenobarbital. Carcinogenesis. 7: 1813-7. PMID 3533304 DOI: 10.1093/Carcin/7.11.1813  0.401
1986 Cruise JL, Cotecchia S, Michalopoulos G. Norepinephrine decreases EGF binding in primary rat hepatocyte cultures. Journal of Cellular Physiology. 127: 39-44. PMID 3007540 DOI: 10.1002/Jcp.1041270106  0.371
1986 Gebhardt R, Cruise J, Houck KA, Luetteke NC, Novotny A, Thaler F, Michalopoulos GK. Differential effect of growth factors on growth stimulation and phenotypic stability of glutamine-synthetase-positive and -negative hepatocytes in primary culture. Differentiation; Research in Biological Diversity. 33: 45-55. PMID 2880778 DOI: 10.1111/J.1432-0436.1986.Tb00409.X  0.439
1985 Bartolome J, Grignolo A, Bartolome M, Trepanier P, Lerea L, Weigel S, Whitmore W, Michalopoulos G, Kavlock R, Slotkin T. Postnatal methyl mercury exposure: effects on ontogeny of renal and hepatic ornithine decarboxylase responses to trophic stimuli. Toxicology and Applied Pharmacology. 80: 147-54. PMID 4024102 DOI: 10.1016/0041-008X(85)90109-7  0.318
1985 Cruise JL, Michalopoulos G. Norepinephrine and epidermal growth factor: dynamics of their interaction in the stimulation of hepatocyte DNA synthesis. Journal of Cellular Physiology. 125: 45-50. PMID 3876347 DOI: 10.1002/Jcp.1041250107  0.379
1985 Houck KA, Michalopoulos G. Proline is required for the stimulation of DNA synthesis in hepatocyte cultures by EGF. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 21: 121-4. PMID 3874201 DOI: 10.1007/Bf02620953  0.322
1985 Luetteke NC, Michalopoulos GK. Partial Purification and Characterization of a Hepatocyte Growth Factor Produced by Rat Hepatocellular Carcinoma Cells Cancer Research. 45: 6331-6337. PMID 2998598  0.334
1985 Cruise JL, Houck KA, Michalopoulos GK. Induction of DNA synthesis in cultured rat hepatocytes through stimulation of α1 adrenoreceptor by norepinephrine Science. 227: 749-751. PMID 2982212 DOI: 10.1126/Science.2982212  0.343
1985 Feldman SR, Rosenberg MR, Ney KA, Michalopoulos G, Pizzo SV. Binding of alpha 2-macroglobulin to hepatocytes: mechanism of in vivo clearance. Biochemical and Biophysical Research Communications. 128: 795-802. PMID 2581569 DOI: 10.1016/0006-291X(85)90117-2  0.383
1984 Butterworth BE, Bermudez E, Smith-Oliver T, Earle L, Cattley R, Martin J, Popp JA, Strom S, Jirtle R, Michalopoulos G. Lack of genotoxic activity of di(2-ethylhexyl)phthalate (DEHP) in rat and human hepatocytes. Carcinogenesis. 5: 1329-35. PMID 6488454 DOI: 10.1093/Carcin/5.10.1329  0.373
1983 Strom SC, Jirtle RL, Michalopoulos G. Genotoxic effects of 2-acetylaminofluorene on rat and human hepatocytes. Environmental Health Perspectives. 49: 165-70. PMID 6832090 DOI: 10.1289/Ehp.8349165  0.361
1983 Butterworth BE, Earle LL, Strom S, Jirtle R, Michalopoulos G. Induction of DNA repair in human and rat hepatocytes by 1,6-dinitropyrene. Mutation Research. 122: 73-80. PMID 6621596 DOI: 10.1016/0165-7992(83)90145-8  0.313
1983 Strom SC, Novicki DL, Novotny A, Jirtle RL, Michalopoulos G. Human hepatocyte-mediated mutagenesis and DNA repair activity. Carcinogenesis. 4: 683-6. PMID 6407771 DOI: 10.1093/Carcin/4.6.683  0.359
1983 Novicki DL, Jirtle RL, Michalopoulos G. Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol. In Vitro. 19: 191-202. PMID 6131863 DOI: 10.1007/Bf02618059  0.354
1983 Rosenberg MR, Strom SC, Michalopoulos G. Effect of hydrocortisone and nicotinamide on gamma glutamyltransferase in primary cultures of rat hepatocytes. In Vitro. 18: 775-82. PMID 6129190 DOI: 10.1007/Bf02796501  0.418
1982 Kligerman AD, Strom SC, Michalopoulos G. Sister chromatid exchange studies in human fibroblast-rat hepatocyte co-cultures: a new in vitro system to study SCEs. Environmental Mutagenesis. 2: 157-65. PMID 7327165 DOI: 10.1002/Em.2860020208  0.364
1982 Novicki DL, Irons GP, Strom SC, Jirtle R, Michalopoulos G. Cryopreservation of isolated rat hepatocytes. In Vitro. 18: 393-9. PMID 7118127 DOI: 10.1007/Bf02796340  0.347
1982 Strom SC, Jirtle RL, Jones RS, Novicki DL, Rosenberg MR, Novotny A, Irons G, McLain JR, Michalopoulos G. Isolation, Culture, and Transplantation of Human Hepatocytes Journal of the National Cancer Institute. 68: 771-778. DOI: 10.1093/Jnci/68.5.771  0.42
1982 Strom SC, Michalopoulos G. [29] Collagen as a substrate for cell growth and differentiation Methods in Enzymology. 82: 544-555. DOI: 10.1016/0076-6879(82)82086-7  0.332
1981 Strom S, Kligerman AD, Michalopoulos G. Comparisons of the effects of chemical carcinogens in mixed cultures of rat hepatocytes and human fibroblasts Carcinogenesis. 2: 709-715. PMID 6269772 DOI: 10.1093/Carcin/2.8.709  0.345
1980 Michalopoulos G, Russell F, Biles C. Primary cultures of hepatocytes on human fibroblasts. In Vitro. 15: 796-806. PMID 118106 DOI: 10.1007/Bf02618306  0.353
1979 Fahl WE, Michalopoulos G, Sattler GL, Jefcoate CR, Pitot HC. Characteristcs of microsomal enzyme controls in primary cultures of rat hepatocytes. Archives of Biochemistry and Biophysics. 192: 61-72. PMID 107860 DOI: 10.1016/0003-9861(79)90071-7  0.417
1976 Michalopoulos G, Sattler CA, Sattler GL, Pitot HC. Cytochrome P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes. Science (New York, N.Y.). 193: 907-9. PMID 948753 DOI: 10.1126/Science.948753  0.37
1976 Michalopoulos G, Sattler GL, Pitot HC. Maintenance of microsomal cytochromes b5 and P-450 in primary cultures of parenchymal liver cells on collagen membranes. Life Sciences. 18: 1139-44. PMID 933703 DOI: 10.1016/0024-3205(76)90149-1  0.354
1976 Michalopoulos G, Pitot HC. Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. Experimental Cell Research. 94: 70-8. PMID 243 DOI: 10.1016/0014-4827(75)90532-7  0.438
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