George K. Michalopoulos - Publications

University of Pittsburgh, Pittsburgh, PA, United States 
Pathology, Biochemistry

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Xue Y, Bhushan B, Mars WM, Bowen W, Tao J, Orr A, Stoops J, Yu Y, Luo J, Duncan A, Michalopoulos GK. p-Ezrin (Thr567) regulates Hippo pathway and Yap in liver. The American Journal of Pathology. PMID 32289287 DOI: 10.1016/j.ajpath.2020.03.014  0.76
2019 Norris CA, He M, Kang LI, Ding MQ, Radder JE, Haynes MM, Yang Y, Paranjpe S, Bowen WC, Orr A, Michalopoulos GK, Stolz DB, Mars WM. Correction: Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli. Plos One. 14: e0224498. PMID 31644563 DOI: 10.1371/journal.pone.0224498  0.76
2019 Bhushan B, Banerjee S, Paranjpe S, Koral K, Mars WM, Stoops JW, Orr A, Bowen WC, Locker J, Michalopoulos GK. Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Non-alcoholic Fatty Liver Disease in Murine Fast-food Diet Model. Hepatology (Baltimore, Md.). PMID 31063640 DOI: 10.1002/hep.30696  0.76
2019 Coudriet GM, Stoops J, Orr AV, Bhushan B, Koral K, Lee S, Previte DM, Dong HH, Michalopoulos GK, Mars WM, Piganelli JD. A Noncanonical Role for Plasminogen Activator Inhibitor Type 1 in Obesity-Induced Diabetes. The American Journal of Pathology. PMID 31054988 DOI: 10.1016/j.ajpath.2019.04.004  0.76
2018 Koral K, Haynes M, Bowen WC, Orr A, Mars W, Michalopoulos GK. Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation. The American Journal of Pathology. 188: 2074-2086. PMID 30126548 DOI: 10.1016/j.ajpath.2018.06.005  0.6
2018 Tsagianni A, Mars WM, Bhushan B, Bowen WC, Orr A, Stoops J, Paranjpe S, Tseng GC, Liu S, Michalopoulos GK. Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor (EGFR) Signaling Causes Liver Failure in Normal Mice. The American Journal of Pathology. PMID 30031724 DOI: 10.1016/j.ajpath.2018.06.009  0.76
2018 Bhushan B, Stoops JW, Mars WM, Orr A, Bowen WC, Paranjpe S, Michalopoulos GK. TCPOBOP-induced hepatomegaly & hepatocyte proliferation is attenuated by combined disruption of MET & EGFR signaling. Hepatology (Baltimore, Md.). PMID 29888801 DOI: 10.1002/hep.30109  0.76
2018 Yokota S, Ono Y, Nakao T, Zhang P, Michalopoulos GK, Khan Z. Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis. Journal of Visualized Experiments : Jove. PMID 29658929 DOI: 10.3791/56930  1
2018 Xue Y, Mars WM, Bowen W, Singhi AD, Stoops J, Michalopoulos GK. Hepatitis C Virus (HCV) Mimics Effects of Glypican-3 (GPC3) on CD81 and Promotes Development of Hepatocellular Carcinomas via Activation of Hippo Pathway in Hepatocytes. The American Journal of Pathology. PMID 29577937 DOI: 10.1016/j.ajpath.2018.02.013  0.76
2017 Doffou M, Adams G, Bowen WC, Paranjpe S, Parihar HS, Nguyen H, Michalopoulos GK, Bhave V. Oct4 is crucial for transdifferentiation of hepatocytes to biliary epithelial cells in an in vitro organoid culture model. Gene Expression. PMID 29212575 DOI: 10.3727/105221617X15124876321401  0.6
2017 Chen ZH, Yu YP, Zuo ZH, Nelson JB, Michalopoulos GK, Monga S, Liu S, Tseng G, Luo JH. Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene. Nature Biotechnology. PMID 28459452 DOI: 10.1038/nbt.3843  0.48
2017 Khan Z, Orr A, Michalopoulos GK, Ranganathan S. Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease. Pediatric and Developmental Pathology : the Official Journal of the Society For Pediatric Pathology and the Paediatric Pathology Society. 20: 16-27. PMID 28276299 DOI: 10.1177/1093526616686244  1
2017 Chen ZH, Yu YP, Tao J, Liu S, Tseng G, Nalesnik M, Hamilton R, Bhargava R, Nelson JB, Pennathur A, Monga SP, Luketich JD, Michalopoulos GK, Luo JH. MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. Gastroenterology. PMID 28245430 DOI: 10.1053/j.gastro.2016.12.036  0.48
2016 Khan Z, Yokota S, Ono Y, Bell AW, Stolz DB, Michalopoulos GK. BILE DUCT LIGATION INDUCES ATZ GLOBULE CLEARANCE IN A MOUSE MODEL OF ALPHA-1 ANTITRYPSIN DEFICIENCY. Gene Expression. PMID 27543967 DOI: 10.3727/105221616X692991  1
2016 Paranjpe S, Bowen WC, Mars WM, Orr A, Haynes MM, DeFrances MC, Liu S, Tseng GC, Tsagianni A, Michalopoulos GK. Combined systemic elimination of MET and EGFR signaling completely abolishes liver regeneration and leads to liver decompensation. Hepatology (Baltimore, Md.). PMID 27397846 DOI: 10.1002/hep.28721  0.76
2016 Yu C, Yan S, Khambu B, Chen X, Dong Z, Luo J, Michalopoulos GK, Wu S, Yin XM. Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. Plos One. 11: e0155211. PMID 27196317 DOI: 10.1371/journal.pone.0155211  0.36
2016 Bhushan B, Michalopoulos G, Apte U, Edwards G, Desai A. Liver-specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration after Acetaminophen Overdose. Gene Expression. PMID 27125733 DOI: 10.3727/105221616X691578  0.36
2016 Khan Z, Orr AV, Michalopoulos GK, Ranganathan S. IMMUNOHISTOCHEMICAL ANALYSIS OF THE STEM CELL MARKER LGR5 IN PEDIATRIC LIVER DISEASE. Pediatric and Developmental Pathology : the Official Journal of the Society For Pediatric Pathology and the Paediatric Pathology Society. PMID 27019151 DOI: 10.2350/15-07-1668-OA.1  1
2015 Michalopoulos GK, Khan Z. Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease. Gastroenterology. 149: 876-82. PMID 26278502 DOI: 10.1053/j.gastro.2015.08.004  1
2015 Kang LI, Isse K, Koral K, Bowen WC, Muratoglu S, Strickland DK, Michalopoulos GK, Mars WM. Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1. Laboratory Investigation; a Journal of Technical Methods and Pathology. 95: 1117-29. PMID 26237273 DOI: 10.1038/labinvest.2015.94  0.36
2015 Koral K, Paranjpe S, Bowen WC, Mars W, Luo J, Michalopoulos GK. Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma. Hepatology (Baltimore, Md.). 61: 537-47. PMID 25234543 DOI: 10.1002/hep.27444  1
2015 Han C, Michalopoulos GK, Wu T. Prostaglandin E2 Receptor EP1 Transactivates EGFR/MET Receptor Tyrosine Kinases and Enhances Invasiveness in Human Hepatocellular Carcinoma Cells Journal of Cellular Physiology. 230: 1401-1401. DOI: 10.1002/jcp.24869  1
2014 Yu YP, Ding Y, Chen Z, Liu S, Michalopoulos A, Chen R, Gulzar ZG, Yang B, Cieply KM, Luvison A, Ren BG, Brooks JD, Jarrard D, Nelson JB, Michalopoulos GK, et al. Novel fusion transcripts associate with progressive prostate cancer. The American Journal of Pathology. 184: 2840-9. PMID 25238935 DOI: 10.1016/j.ajpath.2014.06.025  1
2014 Michalopoulos GK. Advances in liver regeneration. Expert Review of Gastroenterology & Hepatology. 8: 897-907. PMID 24964729 DOI: 10.1586/17474124.2014.934358  1
2014 Norris CA, He M, Kang LI, Ding MQ, Radder JE, Haynes MM, Yang Y, Paranjpe S, Bowen WC, Orr A, Michalopoulos GK, Stolz DB, Mars WM. Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli. Plos One. 9: e96053. PMID 24763697 DOI: 10.1371/journal.pone.0096053  1
2014 Bowen WC, Michalopoulos AW, Orr A, Ding MQ, Stolz DB, Michalopoulos GK. Development of a chemically defined medium and discovery of new mitogenic growth factors for mouse hepatocytes: mitogenic effects of FGF1/2 and PDGF. Plos One. 9: e95487. PMID 24743506 DOI: 10.1371/journal.pone.0095487  1
2014 Michalopoulos GK. NRF2, not always friendly but perhaps misunderstood. Hepatology (Baltimore, Md.). 60: 461-3. PMID 24700292 DOI: 10.1002/hep.27090  1
2014 Michalopoulos GK. The liver is a peculiar organ when it comes to stem cells. The American Journal of Pathology. 184: 1263-7. PMID 24681248 DOI: 10.1016/j.ajpath.2014.02.020  1
2014 Davison JM, Yee M, Krill-Burger JM, Lyons-Weiler MA, Kelly LA, Sciulli CM, Nason KS, Luketich JD, Michalopoulos GK, LaFramboise WA. The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma. Plos One. 9: e79079. PMID 24454681 DOI: 10.1371/journal.pone.0079079  1
2013 Donthamsetty S, Bhave VS, Mars WM, Bowen WC, Orr A, Haynes MM, Wu C, Michalopoulos GK. Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. Plos One. 8: e74625. PMID 24058607 DOI: 10.1371/journal.pone.0074625  1
2013 Michalopoulos GK, Grompe M, Theise ND. Assessing the potential of induced liver regeneration. Nature Medicine. 19: 1096-7. PMID 24013747 DOI: 10.1038/nm.3325  1
2013 Michalopoulos GK. Principles of liver regeneration and growth homeostasis. Comprehensive Physiology. 3: 485-513. PMID 23720294 DOI: 10.1002/cphy.c120014  1
2013 Bhave VS, Mars W, Donthamsetty S, Zhang X, Tan L, Luo J, Bowen WC, Michalopoulos GK. Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. The American Journal of Pathology. 183: 153-9. PMID 23665349 DOI: 10.1016/j.ajpath.2013.03.013  1
2013 Nejak-Bowen KN, Orr AV, Bowen WC, Michalopoulos GK. Gliotoxin-induced changes in rat liver regeneration after partial hepatectomy. Liver International : Official Journal of the International Association For the Study of the Liver. 33: 1044-55. PMID 23552057 DOI: 10.1111/liv.12164  1
2013 Nejak-Bowen K, Orr A, Bowen WC, Michalopoulos GK. Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy. Plos One. 8: e59836. PMID 23527275 DOI: 10.1371/journal.pone.0059836  1
2013 Hattoum A, Rubin E, Orr A, Michalopoulos GK. Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failure. Human Pathology. 44: 743-9. PMID 23114924 DOI: 10.1016/j.humpath.2012.07.018  1
2012 Kang LI, Mars WM, Michalopoulos GK. Signals and cells involved in regulating liver regeneration. Cells. 1: 1261-92. PMID 24710554 DOI: 10.3390/cells1041261  0.76
2012 Nalesnik MA, Michalopoulos GK. Growth factor pathways in development and progression of hepatocellular carcinoma Frontiers in Bioscience - Scholar. 4: 1487-1515. PMID 22652888  1
2012 Michalopoulos GK. Phenotypic fidelity (or not?) of epithelial cells in the liver. Hepatology (Baltimore, Md.). 55: 2024-7. PMID 22407729 DOI: 10.1002/hep.25703  1
2012 Nalesnik MA, Tseng G, Ding Y, Xiang GS, Zheng ZL, Yu Y, Marsh JW, Michalopoulos GK, Luo JH. Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation. The American Journal of Pathology. 180: 1495-508. PMID 22326833 DOI: 10.1016/j.ajpath.2011.12.021  1
2012 Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ. A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology (Baltimore, Md.). 55: 609-21. PMID 21953681 DOI: 10.1002/hep.24713  1
2011 Donthamsetty S, Mars WM, Orr A, Wu C, Michalopoulos GK. Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice. Comparative Hepatology. 10: 11. PMID 22104495 DOI: 10.1186/1476-5926-10-11  1
2011 Bhave VS, Paranjpe S, Bowen WC, Donthamsetty S, Bell AW, Khillan JS, Michalopoulos GK. Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo. Hepatology (Baltimore, Md.). 54: 1360-70. PMID 21739467 DOI: 10.1002/hep.24507  1
2011 Lin CW, Mars WM, Paranjpe S, Donthamsetty S, Bhave VS, Kang LI, Orr A, Bowen WC, Bell AW, Michalopoulos GK. Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice. Hepatology (Baltimore, Md.). 54: 620-30. PMID 21574168 DOI: 10.1002/hep.24417  1
2011 Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, Stewart RE, Orr A, Wu C, Michalopoulos GK. Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene. Hepatology (Baltimore, Md.). 53: 587-95. PMID 21274879 DOI: 10.1002/hep.24040  1
2011 Michalopoulos GK. Liver regeneration: alternative epithelial pathways. The International Journal of Biochemistry & Cell Biology. 43: 173-9. PMID 19788929 DOI: 10.1016/j.biocel.2009.09.014  1
2010 Limaye PB, Bowen WC, Orr A, Apte UM, Michalopoulos GK. Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation. Comparative Hepatology. 9: 9. PMID 21126359 DOI: 10.1186/1476-5926-9-9  1
2010 Liu B, Bell AW, Paranjpe S, Bowen WC, Khillan JS, Luo JH, Mars WM, Michalopoulos GK. Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice. Hepatology (Baltimore, Md.). 52: 1060-7. PMID 20812357 DOI: 10.1002/hep.23794  1
2010 Han C, Bowen WC, Li G, Demetris AJ, Michalopoulos GK, Wu T. Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth. Hepatology (Baltimore, Md.). 52: 644-55. PMID 20683962 DOI: 10.1002/hep.23703  1
2010 Ni HM, Baty CJ, Li N, Ding WX, Gao W, Li M, Chen X, Ma J, Michalopoulos GK, Yin XM. Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis. Hepatology (Baltimore, Md.). 52: 338-48. PMID 20578150 DOI: 10.1002/hep.23672  1
2010 Han YC, Yu YP, Nelson J, Wu C, Wang H, Michalopoulos GK, Luo JH. Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression. Cancer Research. 70: 4375-84. PMID 20460506 DOI: 10.1158/0008-5472.CAN-09-4403  1
2010 Paranjpe S, Bowen WC, Tseng GC, Luo JH, Orr A, Michalopoulos GK. RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats. The American Journal of Pathology. 176: 2669-81. PMID 20395437 DOI: 10.2353/ajpath.2010.090605  1
2010 Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. The American Journal of Pathology. 176: 2-13. PMID 20019184 DOI: 10.2353/ajpath.2010.090675  1
2010 Bae MH, Bissonette GB, Mars WM, Michalopoulos GK, Achim CL, Depireux DA, Powell EM. Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility. Experimental Neurology. 221: 129-35. PMID 19853606 DOI: 10.1016/j.expneurol.2009.10.011  1
2009 Ullrich A, Stolz DB, Ellis EC, Strom SC, Michalopoulos GK, Hengstler JG, Runge D. Long term cultures of primary human hepatocytes as an alternative to drug testing in animals. Altex. 26: 295-302. PMID 20383475  1
2009 Apte U, Gkretsi V, Bowen WC, Mars WM, Luo JH, Donthamsetty S, Orr A, Monga SP, Wu C, Michalopoulos GK. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology (Baltimore, Md.). 50: 844-51. PMID 19575460 DOI: 10.1002/hep.23059  1
2009 Liu B, Paranjpe S, Bowen WC, Bell AW, Luo JH, Yu YP, Mars WM, Michalopoulos GK. Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation. The American Journal of Pathology. 175: 717-24. PMID 19574424 DOI: 10.2353/ajpath.2009.081129  1
2009 Michalopoulos GK, DeFrances MC. Hepatic Regeneration Textbook of Gastroenterology, Fifth Edition. 1: 680-702. DOI: 10.1002/9781444303254.ch28  1
2008 Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK. Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (Baltimore, Md.). 48: 1932-41. PMID 18846549 DOI: 10.1002/hep.22537  1
2008 Limaye PB, Alarcón G, Walls AL, Nalesnik MA, Michalopoulos GK, Demetris AJ, Ochoa ER. Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 865-72. PMID 18574450 DOI: 10.1038/labinvest.2008.56  1
2008 Giannopoulou M, Dai C, Tan X, Wen X, Michalopoulos GK, Liu Y. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. The American Journal of Pathology. 173: 30-41. PMID 18502824 DOI: 10.2353/ajpath.2008.070583  1
2008 Limaye PB, Bowen WC, Orr AV, Luo J, Tseng GC, Michalopoulos GK. Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium. Hepatology (Baltimore, Md.). 47: 1702-13. PMID 18398918 DOI: 10.1002/hep.22221  1
2008 Tan X, Yuan Y, Zeng G, Apte U, Thompson MD, Cieply B, Stolz DB, Michalopoulos GK, Kaestner KH, Monga SP. Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology (Baltimore, Md.). 47: 1667-79. PMID 18393386 DOI: 10.1002/hep.22225  1
2008 Han C, Bowen WC, Michalopoulos GK, Wu T. Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes. Journal of Cellular Physiology. 216: 486-97. PMID 18314882 DOI: 10.1002/jcp.21420  1
2007 Song JS, Murase N, Demetris AJ, Michalopoulos GK, Ochoa ER. Protection from acute cellular injury using Sleeping Beauty mediated telomerase gene transfer. Biochemical and Biophysical Research Communications. 363: 253-6. PMID 17869215 DOI: 10.1016/j.bbrc.2007.05.213  1
2007 Zou C, Ma J, Wang X, Guo L, Zhu Z, Stoops J, Eaker AE, Johnson CJ, Strom S, Michalopoulos GK, DeFrances MC, Zarnegar R. Lack of Fas antagonism by Met in human fatty liver disease. Nature Medicine. 13: 1078-85. PMID 17704785 DOI: 10.1038/nm1625  1
2007 Zhao Y, Difrancesca D, Wang X, Zarnegar R, Michalopoulos GK, Yin XM. Promotion of Fas-mediated apoptosis in Type II cells by high doses of hepatocyte growth factor bypasses the mitochondrial requirement. Journal of Cellular Physiology. 213: 556-63. PMID 17620325 DOI: 10.1002/jcp.21136  1
2007 Michalopoulos GK. Liver regeneration. Journal of Cellular Physiology. 213: 286-300. PMID 17559071 DOI: 10.1002/jcp.21172  1
2007 Ren B, Yu YP, Tseng GC, Wu C, Chen K, Rao UN, Nelson J, Michalopoulos GK, Luo JH. Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma. Journal of the National Cancer Institute. 99: 868-80. PMID 17551147 DOI: 10.1093/jnci/djk199  1
2007 Paranjpe S, Bowen WC, Bell AW, Nejak-Bowen K, Luo JH, Michalopoulos GK. Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference. Hepatology (Baltimore, Md.). 45: 1471-7. PMID 17427161 DOI: 10.1002/hep.21570  1
2007 Gkretsi V, Mars WM, Bowen WC, Barua L, Yang Y, Guo L, St-Arnaud R, Dedhar S, Wu C, Michalopoulos GK. Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis. Hepatology (Baltimore, Md.). 45: 1025-34. PMID 17385211 DOI: 10.1002/hep.21540  1
2007 Uppal H, Saini SP, Moschetta A, Mu Y, Zhou J, Gong H, Zhai Y, Ren S, Michalopoulos GK, Mangelsdorf DJ, Xie W. Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology (Baltimore, Md.). 45: 422-32. PMID 17256725 DOI: 10.1002/hep.21494  1
2007 Gkretsi V, Bowen WC, Yang Y, Wu C, Michalopoulos GK. Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation. Biochemical and Biophysical Research Communications. 353: 638-43. PMID 17194454 DOI: 10.1016/j.bbrc.2006.12.091  1
2006 Tan X, Behari J, Cieply B, Michalopoulos GK, Monga SP. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology. 131: 1561-72. PMID 17101329 DOI: 10.1053/j.gastro.2006.08.042  1
2006 Luo JH, Ren B, Keryanov S, Tseng GC, Rao UN, Monga SP, Strom S, Demetris AJ, Nalesnik M, Yu YP, Ranganathan S, Michalopoulos GK. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology (Baltimore, Md.). 44: 1012-24. PMID 17006932 DOI: 10.1002/hep.21328  1
2006 Khan Z, Michalopoulos GK, Stolz DB. Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. The American Journal of Pathology. 169: 1251-69. PMID 17003483 DOI: 10.2353/ajpath.2006.060360  1
2006 Michalopoulos GK. Flexible lineage specifications of adult hepatic cells, associated molecular pathways, and their relationship to liver cancer. Cell Transplantation. 15: S67-8. PMID 16826797  1
2006 Bell AW, Michalopoulos GK. Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR. Hepatology (Baltimore, Md.). 44: 186-94. PMID 16799975 DOI: 10.1002/hep.21234  1
2006 Xia JL, Dai C, Michalopoulos GK, Liu Y. Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation. The American Journal of Pathology. 168: 1500-12. PMID 16651617 DOI: 10.2353/ajpath.2006.050747  1
2006 Giannopoulou M, Iszkula SC, Dai C, Tan X, Yang J, Michalopoulos GK, Liu Y. Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action. American Journal of Physiology. Renal Physiology. 290: F1234-40. PMID 16332928 DOI: 10.1152/ajprenal.00388.2005  1
2006 Han C, Michalopoulos GK, Wu T. Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. Journal of Cellular Physiology. 207: 261-70. PMID 16331686 DOI: 10.1002/jcp.20560  1
2005 Tan X, Apte U, Micsenyi A, Kotsagrelos E, Luo JH, Ranganathan S, Monga DK, Bell A, Michalopoulos GK, Monga SP. Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology. 129: 285-302. PMID 16012954 DOI: 10.1053/j.gastro.2005.04.013  1
2005 Michalopoulos GK, DeFrances M. Liver regeneration. Advances in Biochemical Engineering/Biotechnology. 93: 101-34. PMID 15791946 DOI: 10.1007/b99968  1
2005 Michalopoulos GK, Barua L, Bowen WC. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology (Baltimore, Md.). 41: 535-44. PMID 15726663 DOI: 10.1002/hep.20600  1
2005 Michalopoulos GK, Khan Z. Liver regeneration, growth factors, and amphiregulin. Gastroenterology. 128: 503-6. PMID 15685562 DOI: 10.1126/science.276.5309.60  1
2004 Yagi Y, Ahmed I, Gross W, Becich MJ, Demetris AJ, Wells A, Wiley CA, Michalopoulos GK, Yousem SA, Barnes B, Gilbertson JR. Webcasting pathology department conferences in a geographically distributed medical center. Human Pathology. 35: 790-7. PMID 15257541 DOI: 10.1016/j.humpath.2004.03.013  1
2004 Köhler C, Bell AW, Bowen WC, Monga SP, Fleig W, Michalopoulos GK. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology (Baltimore, Md.). 39: 1056-65. PMID 15057910 DOI: 10.1002/hep.20156  1
2004 Micsenyi A, Tan X, Sneddon T, Luo JH, Michalopoulos GK, Monga SP. Beta-catenin is temporally regulated during normal liver development. Gastroenterology. 126: 1134-46. PMID 15057752 DOI: 10.1053/j.gastro.2003.12.047  1
2004 Hussain SZ, Sneddon T, Tan X, Micsenyi A, Michalopoulos GK, Monga SP. Wnt impacts growth and differentiation in ex vivo liver development. Experimental Cell Research. 292: 157-69. PMID 14720515 DOI: 10.1016/j.yexcr.2003.08.020  1
2003 Leng J, Han C, Demetris AJ, Michalopoulos GK, Wu T. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology (Baltimore, Md.). 38: 756-68. PMID 12939602 DOI: 10.1053/jhep.2003.50380  1
2003 Michalopoulos GK, Bowen WC, Mulè K, Luo J. HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Gene Expression. 11: 55-75. PMID 12837037  1
2003 Han C, Demetris AJ, Michalopoulos GK, Zhan Q, Shelhamer JH, Wu T. PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway. Hepatology (Baltimore, Md.). 38: 167-77. PMID 12829999 DOI: 10.1053/jhep.2003.50296  1
2003 Ren B, Yu YP, Jing L, Liu L, Michalopoulos GK, Luo JH, Rao UN. Gene expression analysis of human soft tissue leiomyosarcomas. Human Pathology. 34: 549-58. PMID 12827608 DOI: 10.1016/S0046-8177(03)00014-5  1
2003 Schoedel KE, Tyner VZ, Kim TH, Michalopoulos GK, Mars WM. HGF, MET, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 16: 14-21. PMID 12527708 DOI: 10.1097/01.MP.0000043521.96995.DB  1
2003 Monga SP, Monga HK, Tan X, Mulé K, Pediaditakis P, Michalopoulos GK. Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology. 124: 202-16. PMID 12512043 DOI: 10.1053/gast.2003.50000  1
2002 Michalopoulos GK, Bowen WC, Mulè K, Lopez-Talavera JC, Mars W. Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology (Baltimore, Md.). 36: 278-83. PMID 12143035 DOI: 10.1053/jhep.2002.34858  1
2002 Monga SP, Mars WM, Pediaditakis P, Bell A, Mulé K, Bowen WC, Wang X, Zarnegar R, Michalopoulos GK. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Research. 62: 2064-71. PMID 11929826  1
2002 Wang X, DeFrances MC, Dai Y, Pediaditakis P, Johnson C, Bell A, Michalopoulos GK, Zarnegar R. A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Molecular Cell. 9: 411-21. PMID 11864613 DOI: 10.1016/S1097-2765(02)00439-2  1
2002 Pediaditakis P, Monga SP, Mars WM, Michalopoulos GK. Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa. The Journal of Biological Chemistry. 277: 14109-15. PMID 11832492 DOI: 10.1074/jbc.M112196200  1
2001 Michalopoulos GK, Bowen WC, Mulè K, Stolz DB. Histological organization in hepatocyte organoid cultures. The American Journal of Pathology. 159: 1877-87. PMID 11696448 DOI: 10.1016/S0002-9440(10)63034-9  1
2001 Pediaditakis P, Lopez-Talavera JC, Petersen B, Monga SP, Michalopoulos GK. The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat. Hepatology (Baltimore, Md.). 34: 688-93. PMID 11584364 DOI: 10.1053/jhep.2001.27811  1
2001 Monga SP, Pediaditakis P, Mule K, Stolz DB, Michalopoulos GK. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology (Baltimore, Md.). 33: 1098-109. PMID 11343237 DOI: 10.1053/jhep.2001.23786  1
2001 Yang J, Chen S, Huang L, Michalopoulos GK, Liu Y. Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth Hepatology. 33: 848-859. PMID 11283849 DOI: 10.1053/jhep.2001.23438  1
2001 Rao UNM, Gollin SM, Beaves S, Cieply K, Nalesnik M, Michalopoulos GK. Comparative genomic hybridization of hepatocellular carcinoma: Correlation with fluorescence In Situ hybridization in paraffin-embedded tissue Molecular Diagnosis. 6: 27-37. PMID 11257209 DOI: 10.1054/modi.2001.22021  1
2000 Runge D, Michalopoulos GK, Strom SC, Runge DM. Recent advances in human hepatocyte culture systems Biochemical and Biophysical Research Communications. 274: 1-3. PMID 10903886 DOI: 10.1006/bbrc.2000.2912  1
2000 Runge D, Köhler C, Kostrubsky VE, Jäger D, Lehmann T, Runge DM, May U, Stolz DB, Strom SC, Fleig WE, Michalopoulos GK. Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes Biochemical and Biophysical Research Communications. 273: 333-341. PMID 10873607 DOI: 10.1006/bbrc.2000.2902  1
2000 Runge D, Fleig WE, Michalopoulos GK, Strom SC, Runge DM. Transplantation of hepatocytes. Possibilities and examples of clinical application Deutsche Medizinische Wochenschrift. 125: 397-400. PMID 10778401  1
2000 Jo M, Stolz DB, Esplen JE, Dorko K, Michalopoulos GK, Strom SC. Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. The Journal of Biological Chemistry. 275: 8806-11. PMID 10722725 DOI: 10.1074/jbc.275.12.8806  1
2000 Runge D, Runge DM, Jäger D, Lubecki KA, Beer Stolz D, Karathanasis S, Kietzmann T, Strom SC, Jungermann K, Fleig WE, Michalopoulos GK. Serum-free, long-term cultures of human hepatocytes: Maintenance of cell morphology, transcription factors, and liver-specific functions Biochemical and Biophysical Research Communications. 269: 46-53. PMID 10694475 DOI: 10.1006/bbrc.2000.2215  1
2000 Kim TH, Mars WM, Stolz DB, Michalopoulos GK. Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration Hepatology. 31: 75-82. PMID 10613731  1
1999 Runge DM, Runge D, Foth H, Strom SC, Michalopoulos GK. Stat 1α/1β, STAT 3 and STAT 5: Expression and association with c-MET and EGF-receptor in long-term cultures of human hepatocytes Biochemical and Biophysical Research Communications. 265: 376-381. PMID 10558875 DOI: 10.1006/bbrc.1999.1681  1
1999 Stolz DB, Ross MA, Salem HM, Mars WM, Michalopoulos GK, Enomoto K. Cationic colloidal silica membrane perturbation as a means of examining changes at the sinusoidal surface during liver regeneration. The American Journal of Pathology. 155: 1487-98. PMID 10550305 DOI: 10.1016/S0002-9440(10)65464-8  1
1999 Welch WC, Kornblith PL, Michalopoulos GK, Petersen BE, Beedle A, Gollin SM, Goldfarb RH. Hepatocyte growth factor (HGF) and receptor (c-met) in normal and malignant astrocytic cells. Anticancer Research. 19: 1635-40. PMID 10470094  1
1999 Stolz DB, Mars WM, Petersen BE, Kim TH, Michalopoulos GK. Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat Cancer Research. 59: 3954-3960. PMID 10463591  1
1999 Runge D, Runge DM, Daskalakis N, Lubecki KA, Bowen WC, Michalopoulos GK. Matrix-mediated changes in the expression of HNF-4alpha isoforms and in DNA-binding activity of ARP-1 in primary cultures of rat hepatocytes. Biochemical and Biophysical Research Communications. 259: 651-5. PMID 10364473 DOI: 10.1006/bbrc.1999.0848  1
1999 Runge DM, Bowen WC, Katyal S, Runge D, Suski V, Michalopoulos GK. Expression of the human hepatocyte growth factor cDNA in primary cultures of rat hepatocytes. Biochemical and Biophysical Research Communications. 257: 199-205. PMID 10092533 DOI: 10.1006/bbrc.1998.9947  1
1999 Runge DM, Runge D, Dorko K, Pisarov LA, Leckel K, Kostrubsky VE, Thomas D, Strom SC, Michalopoulos GK. Epidermal growth factor- and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes Journal of Hepatology. 30: 265-274. PMID 10068107 DOI: 10.1016/S0168-8278(99)80073-7  1
1999 Bell A, Chen Q, DeFrances MC, Michalopoulos GK, Zarnegar R. The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice Oncogene. 18: 887-895. PMID 10023664 DOI: 10.1038/sj.onc.1202379  1
1999 Michalopoulos GK, Bowen WC, Zajac VF, Beer-Stolz D, Watkins S, Kostrubsky V, Strom SC. Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor. Hepatology (Baltimore, Md.). 29: 90-100. PMID 9862855 DOI: 10.1002/hep.510290149  1
1998 Miyazaki M, Mars WM, Michalopoulos GK, Namba M. Dose-dependent biphasic effects of phenobarbital on growth and differentiation of primary culture rat hepatocytes. Journal of Gastroenterology and Hepatology. 13: S78-S82. PMID 28976694 DOI: 10.1111/jgh.1998.13.s1.78  0.76
1998 Runge D, Runge DM, Drenning SD, Bowen WC, Grandis JR, Michalopoulos GK. Growth and differentiation of rat hepatocytes: changes in transcription factors HNF-3, HNF-4, STAT-3, and STAT-5. Biochemical and Biophysical Research Communications. 250: 762-8. PMID 9784420 DOI: 10.1006/bbrc.1998.9384  1
1998 Kim TH, Bowen WC, Stolz DB, Runge D, Mars WM, Michalopoulos GK. Differential expression and distribution of focal adhesion and cell adhesion molecules in rat hepatocyte differentiation. Experimental Cell Research. 244: 93-104. PMID 9770353 DOI: 10.1006/excr.1998.4209  1
1998 Shima N, Stolz DB, Miyazaki M, Gohda E, Higashio K, Michalopoulos GK. Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor Journal of Cellular Physiology. 177: 130-136. PMID 9731753 DOI: 10.1002/(SICI)1097-4652(199810)177:1<130::AID-JCP14>3.0.CO;2-H  1
1998 Takeshita K, Bowen WC, Michalopoulos GK. Three-dimensional culture of hepatocytes in a continuously flowing medium. In Vitro Cellular & Developmental Biology. Animal. 34: 482-5. PMID 9661052  1
1998 Miyazaki M, Mars WM, Runge D, Kim TH, Bowen WC, Michalopoulos GK. Phenobarbital suppresses growth and accelerates restoration of differentiation markers of primary culture rat hepatocytes in the chemically defined hepatocyte growth medium containing hepatocyte growth factor and epidermal growth factor. Experimental Cell Research. 241: 445-57. PMID 9637786 DOI: 10.1006/excr.1998.4085  1
1998 Petersen BE, Zajac VF, Michalopoulos GK. Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats Hepatology. 27: 1030-1038. PMID 9537443 DOI: 10.1002/hep.510270419  1
1998 Oshika E, Liu S, Singh G, Michalopoulos GK, Shinozuka H, Katyal SL. Antagonistic effects of dexamethasone and retinoic acid on rat lung morphogenesis. Pediatric Research. 43: 315-24. PMID 9505268 DOI: 10.1203/00006450-199804001-01874  1
1998 Oshika E, Liu S, Ung LP, Singh G, Shinozuka H, Michalopoulos GK, Katyal SL. Glucocorticoid-induced effects on pattern formation and epithelial cell differentiation in early embryonic rat lungs. Pediatric Research. 43: 305-14. PMID 9505267 DOI: 10.1203/00006450-199804001-01814  1
1998 Stolz DB, Michalopoulos GK. Differential modulation of hepatocyte growth factor-stimulated motility by transforming growth factor β1 on rat liver epithelial cells in vitro Journal of Cellular Physiology. 175: 30-40. PMID 9491778 DOI: 10.1002/(SICI)1097-4652(199804)175:1<30::AID-JCP4>3.0.CO;2-D  1
1998 Petersen BE, Goff JP, Greenberger JS, Michalopoulos GK. Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat Hepatology. 27: 433-445. PMID 9462642 DOI: 10.1002/hep.510270218  1
1998 Miyazaki M, Mars WM, Michalopoulos GK, Namba M. Dose-dependent biphasic effects of phenobarbital on growth and differentiation of primary culture rat hepatocytes Journal of Gastroenterology and Hepatology (Australia). 13.  1
1998 Mars WM, Stolz DB, Kim TY, Runge DM, Michalopoulos GK. Activation of HGF occurs in a complex with c-MET, LRP (A2MR), single chain u-PA and u-PAR Faseb Journal. 12.  1
1998 Runge DM, Runge D, Dorko K, Pisarov LA, Leckel K, Kostrubsky VE, Strom SC, Michalopoulos GK. Effects of dexamethasone and nicotinamide on DNA synthesis and growth factor receptor expression in long-term cultures of human hepatocytes Faseb Journal. 12.  1
1997 Runge D, Runge DM, Bowen WC, Locker J, Michalopoulos GK. Matrix induced re-differentiation of cultured rat hepatocytes and changes of CCAAT/enhancer binding proteins. Biological Chemistry. 378: 873-81. PMID 9377484  1
1997 Achim CL, Katyal S, Wiley CA, Shiratori M, Wang G, Oshika E, Petersen BE, Li JM, Michalopoulos GK. Expression of HGF and cMet in the developing and adult brain. Brain Research. Developmental Brain Research. 102: 299-303. PMID 9352114 DOI: 10.1016/S0165-3806(97)00108-9  1
1997 Kim TH, Mars WM, Stolz DB, Petersen BE, Michalopoulos GK. Extracellular matrix remodeling at the early stages of liver regeneration in the rat Hepatology. 26: 896-904. PMID 9328311  1
1997 Petersen BE, Zajac VF, Michalopoulos GK. Bile ductular damage induced by methylene dianiline inhibits oval cell activation American Journal of Pathology. 151: 905-909. PMID 9327722  1
1997 Rao UNM, Sonmez-Alpan E, Michalopoulos GK. Hepatocyte growth factor and c-MET in benign and malignant peripheral nerve sheath tumors Human Pathology. 28: 1066-1070. PMID 9308731 DOI: 10.1016/S0046-8177(97)90060-5  1
1997 Presnell SC, Stolz DB, Mars WM, Jo M, Michalopoulos GK, Strom SC. Modifications of the hepatocyte growth factor/c-met pathway by constitutive expression of transforming growth factor-alpha in rat liver epithelial cells. Molecular Carcinogenesis. 18: 244-55. PMID 9142219 DOI: 10.1002/(SICI)1098-2744(199704)18:4<244::AID-MC8>3.0.CO;2-D  1
1997 Stolz DB, Michalopoulos GK. Synergistic enhancement of EGF, but not HGF, stimulated hepatocyte motility by TGF-β1 in vitro Journal of Cellular Physiology. 170: 57-68. PMID 9012785 DOI: 10.1002/(SICI)1097-4652(199701)170:1<57::AID-JCP7>3.0.CO;2-K  1
1997 Wagner WR, Muzzio DJ, Rilo HR, Deglau T, Ataai MM, Michalopoulos GK, Block GD. Effect of growth factors and defined medium on primary hepatocyte culture on polyester carriers with varying surface treatment Tissue Engineering. 3: 289-301. DOI: 10.1089/ten.1997.3.289  1
1996 Yamaguchi K, Nalesnik MA, Michalopoulos GK. Expression of HGF mRNA in human rejecting kidney as evidenced by in situ hybridization Urological Research. 24: 349-354. PMID 9008328 DOI: 10.1007/BF00389792  1
1996 Goff JP, Shields DS, Petersen BE, Zajac VF, Michalopoulos GK, Greenberger JS. Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are the result of c-met receptor expression Stem Cells. 14: 592-602. PMID 8888500  1
1996 Yamaguchi K, Nalesnik MA, Michalopoulos GK. Hepatocyte growth factor mRNA in human liver cirrhosis as evidenced by in situ hybrdization Scandinavian Journal of Gastroenterology. 31: 921-927. PMID 8888442  1
1996 Mars WM, Kim TH, Stolz DB, Liu ML, Michalopoulos GK. Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor Cancer Research. 56: 2837-2843. PMID 8665523  1
1996 Block GD, Locker J, Bowen WC, Petersen BE, Katyal S, Strom SC, Riley T, Howard TA, Michalopoulos GK. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. The Journal of Cell Biology. 132: 1133-49. PMID 8601590 DOI: 10.1083/jcb.132.6.1133  1
1996 Runge DM, Michalopoulos GK. HGF, EGF, and retrovirus-mediated gene transfer into cultured rat hepatocytes Faseb Journal. 10.  1
1996 Takeshita K, Bowen WC, Michalopoulos GK. Three dimensional culture of hepatocytes in continuously flowing medium: Early enhanced DNA-synthesis and viability Faseb Journal. 10.  1
1996 Bell A, Liu Y, Michalopoulos GK, Zarnegar R. Transcriptional regulation of the hepatocyte growth factor (HGF) gene in transgenic mice: Identification of cis-acting elements mediating tissue specific and inducible expression in response to tissue regeneration Faseb Journal. 10.  1
1996 Petersen BE, Zaiac VF, Michalopoulos GK. Hepatic oval call activation disrupted when bile duct destruction occurs following methylene dianiline exposure Faseb Journal. 10.  1
1995 Michalopoulos GK. HGF in liver regeneration and tumor promotion Progress in Clinical and Biological Research. 391: 179-185. PMID 8532715  1
1995 Zarnegar R, Michalopoulos GK. The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis Journal of Cell Biology. 129: 1177-1180. PMID 7775566 DOI: 10.1083/jcb.129.5.1177  1
1995 Mars WM, Liu ML, Kitson RP, Goldfarb RH, Gabauer MK, Michalopoulos GK. Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration Hepatology. 21: 1695-1701. PMID 7768515 DOI: 10.1016/0270-9139(95)90477-8  1
1995 Liu ML, Mars WM, Michalopoulos GK. Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine Carcinogenesis. 16: 841-843. PMID 7728965 DOI: 10.1093/carcin/16.4.841  1
1994 Liu Y, Michalopoulos GK, Zarnegar R. Structural and functional characterization of the mouse hepatocyte growth factor gene promoter Journal of Biological Chemistry. 269: 4152-4160. PMID 8307976  1
1994 Liu ML, Mars WM, Zarnegar R, Michalopoulos GK. Uptake and distribution of hepatocyte growth factor in normal and regenerating adult rat liver American Journal of Pathology. 144: 129-140. PMID 8291602  1
1994 Liu ML, Mars WM, Zarnegar R, Michalopoulos GK. Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-α in adult rat liver Hepatology. 19: 1521-1527. PMID 8188184  1
1994 Liu Y, Bell AW, Michalopoulos GK, Zarnegar R. The mouse hepatocyte growth factor-encoding gene: structural organization and evolutionary conservation Gene. 144: 179-187. PMID 8039703 DOI: 10.1016/0378-1119(94)90376-X  1
1994 Stolz DB, Michalopoulos GK. Comparative effects of hepatocyte growth factor and epidermal growth factor on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytes Journal of Cellular Biochemistry. 55: 445-464. PMID 7962176  1
1994 Petersen B, Yee CJ, Bowen W, Zarnegar R, Michalopoulos GK. Distinct morphological and mito-inhibitory effects induced by TGF-β1, HGF and EGF on mouse, rat and human hepatocytes Cell Biology and Toxicology. 10: 219-230. PMID 7895151 DOI: 10.1007/BF00756762  1
1994 Michalopoulos GK. Control mechanisms of liver regeneration Journal of Gastroenterology. 29: 23-29. PMID 7522836  1
1994 Evans BA, Song KC, Strom SC, Zarnegar R, Bahnson R, Bisceglia MH, Michalopoulos GK, Becich MJ. Optimizing immunohistochemical staining for the HGF receptor c-MET in formalin-fixed paraffin-embedded archival human tissue Proceedings - Annual Meeting, Microscopy Society of America. 230-231.  1
1993 Michalopoulos GK. Pathology and molecular diagnostics: Issues of structure and organization American Journal of Pathology. 142: 1297-1299. PMID 8476000  1
1993 Appasamy R, Tanabe M, Murase N, Zarnegar R, Venkataramanan R, Van Thiel DH, Michalopoulos GK. Hepatocyte growth factor, blood clearance, organ uptake, and biliary excretion in normal and partially hepatectomized rats Laboratory Investigation. 68: 270-276. PMID 8450646  1
1993 Michalopoulos GK, Appasamy R. Metabolism of HGF-SF and its role in liver regeneration Exs. 65: 275-283. PMID 8422547  1
1993 Mars WM, Zarnegar R, Michalopoulos GK. Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA American Journal of Pathology. 143: 949-958. PMID 8362987  1
1993 Michalopoulos GK, Bowen W, Nussler AK, Becich MJ, Howard TA. Comparative analysis of mitogenic and morphogenic effects of HGF and EGF on rat and human hepatocytes maintained in collagen gels Journal of Cellular Physiology. 156: 443-452. PMID 8360254  1
1993 Yee CJ, Defrances MC, Bell A, Bowen W, Petersen B, Michalopoulos GK, Zarnegar R. Expression and characterization of biologically active human hepatocyte growth factor (HGF) by insect cells infected with HGF-recombinant baculovirus Biochemistry. 32: 7922-7931. PMID 8347597  1
1993 Liu Y, Michalopoulos GK, Zarnegar R. Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor Bba - Gene Structure and Expression. 1216: 299-303. PMID 8241272 DOI: 10.1016/0167-4781(93)90159-B  1
1993 Lindroos P, Michalopoulos GK. Response of phenobarbital- and ciprofibrate-exposed hepatocytes to growth factors in type I collagen gels Carcinogenesis. 14: 731-735. PMID 7682481 DOI: 10.1093/carcin/14.4.731  1
1992 Baffy G, Yang L, Michalopoulos GK, Williamson JR. Hepatocyte growth factor induces calcium mobilization and inositol phosphate production in rat hepatocytes Journal of Cellular Physiology. 153: 332-339. PMID 1429853  1
1992 Wolf HK, Michalopoulos GK. Hepatocyte regeneration in acute fulminant and nonfulminant hepatitis: A study of proliferating cell nuclear antigen expression Hepatology. 15: 707-713. PMID 1372584  1
1992 Lindroos P, Tsai WH, Zarnegar R, Michalopoulos GK. Plasma levels of hgf in rats treated with tumor promoters Carcinogenesis. 13: 139-141. PMID 1370768 DOI: 10.1093/carcin/13.1.139  1
1992 Hernandez J, Zarnegar R, Michalopoulos GK. Characterization of the effects of human placental HGF on rat hepatocytes Journal of Cellular Physiology. 150: 116-121. PMID 1370501  1
1992 Wolf HK, Michalopoulos GK. Proliferating cell nuclear antigen in human placenta and trophoblastic disease Fetal and Pediatric Pathology. 12: 147-154. PMID 1349168 DOI: 10.3109/15513819209023291  1
1992 Kost DP, DeFrances MC, Lee CR, Michalopoulos GK. Patterns of alpha-1-adrenergic receptor expression in regenerating and neoplastic hepatic tissue. Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology. 60: 303-8. PMID 1337829  1
1992 Defrances MC, Wolf HK, Michalopoulos GK, Zarnegar R. The presence of hepatocyte growth factor in the developing rat Development. 116: 387-395. PMID 1286614  1
1991 Skouteris GG, Michalopoulos GK. Synthesis and phosphorylation of an extracellular polypeptide reacting with anti-MYC antisera in primary rat hepatocyte cultures Biochemical and Biophysical Research Communications. 180: 631-637. PMID 1953733 DOI: 10.1016/S0006-291X(05)81112-X  1
1991 Francavilla A, Starzl TE, Porter K, Foglieni CS, Michalopoulos GK, Carrieri G, Trejo J, Azzarone A, Barone M, Zeng QH. Screening for candidate hepatic growth factors by selective portal infusion after canine Eck's fistula Hepatology. 14: 665-670. PMID 1916668  1
1991 Wolf HK, Zarnegar R, Oliver L, Michalopoulos GK. Hepatocyte growth factor in human placenta and trophoblastic disease. The American Journal of Pathology. 138: 1035-43. PMID 1849357  1
1991 Wolf HK, Zarnegar R, Michalopoulos GK. Localization of hepatocyte growth factor in human and rat tissues: An immunohistochemical study Hepatology. 14: 488-494. PMID 1831438  1
1991 Zarnegar R, DeFrances MC, Kost DP, Lindroos P, Michalopoulos GK. Expression of Hepatocyte Growth Factor mRNA in regenerating rat liver after partial hepatectomy Biochemical and Biophysical Research Communications. 177: 559-565. PMID 1828343 DOI: 10.1016/0006-291X(91)92020-K  1
1991 Kost DP, Michalopoulos GK. Effect of 2% dimethyl sulfoxide on the mitogenic properties of epidermal growth factor and hepatocyte growth factor in primary hepatocyte culture Journal of Cellular Physiology. 147: 274-280. PMID 1828251  1
1991 Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK, Comoglio PM. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET Oncogene. 6: 501-504. PMID 1827664  1
1991 Michalopoulos GK, Zarnegar R, Houck K, Pediaditakis P. Hepatopoietins A and B and hepatocyte growth. Digestive Diseases and Sciences. 36: 681-6. PMID 1827065 DOI: 10.1007/BF01297038  1
1991 Lindroos PM, Zarnegar R, Michalopoulos GK. Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration Hepatology. 13: 743-750. PMID 1826282  1
1991 Tsai WH, Zarnegar R, Michalopoulos GK. Long-term treatment with hepatic tumor promoters inhibits mitogenic responses of hepatocytes to acidic fibroblast growth factor and hepatocyte growth factor Cancer Letters. 59: 103-108. PMID 1715812 DOI: 10.1016/0304-3835(91)90173-F  1
1991 Tsai WH, Michalopoulos GK. Responsiveness of hepatocytes to epidermal growth factor, transforming growth factor-beta and norepinephrine during treatment with xenobiotic hepatic tumor promoters Cancer Letters. 57: 83-90. PMID 1709063 DOI: 10.1016/0304-3835(91)90067-R  1
1991 Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto Narsimhan CRP, Hartmann G, Zarnegar R, Michalopoulos GK, Birchmeier W, Comoglio PM. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor Embo Journal. 10: 2867-2878. PMID 1655405  1
1990 Michalopoulos GK. Liver regeneration: Molecular mechanisms of growth control Faseb Journal. 4: 176-187. PMID 2404819  1
1990 Kost DP, Michalopoulos GK. Effect of epidermal growth factor on the expression of protooncogenes c-myc and c-Ha-ras in short-term primary hepatocyte culture Journal of Cellular Physiology. 144: 122-127. PMID 2195043 DOI: 10.1002/jcp.1041440116  1
1990 Houck KA, Zarnegar R, Muga SJ, Michalopoulos GK. Acidic fibroblast growth factor (HBGF-1) stimulates DNA synthesis in primary rat hepatocyte cultures Journal of Cellular Physiology. 143: 129-132. PMID 1690739  1
1989 Houck KA, Michalopoulos GK, Strom SC. Introduction of a Ha-ras oncogene into rat liver epithelial cells and parenchymal hepatocytes confers resistance to the growth inhibitory effects of TGF-β Oncogene. 4: 19-25. PMID 2783773  1
1989 Houck KA, Michalopoulos GK. Altered responses of regenerating hepatocytes to norepinephrine and transforming growth factor type β Journal of Cellular Physiology. 141: 503-509. PMID 2574179 DOI: 10.1002/jcp.1041410308  1
1989 Cruise JL, Muga SJ, Lee YS, Michalopoulos GK. Regulation of hepatocyte growth: Alpha-1 adrenergic receptor and ras p21 changes in liver regeneration Journal of Cellular Physiology. 140: 195-201. PMID 2545731  1
1989 Tsai WH, Cruise JL, Michalopoulos GK. Blockade of α-1 adrenergic receptor inhibits hepatic DNA synthesis stimulated by tumor promoters Carcinogenesis. 10: 73-78. PMID 2463115 DOI: 10.1093/carcin/10.1.73  1
1988 Luetteke NC, Michalopoulos GK, Teixidó J, Gilmore R, Massagué J, Lee DC. Characterization of high molecular weight transforming growth factor α produced by rat hepatocellular carcinoma cells Biochemistry. 27: 6487-6494. PMID 3219349 DOI: 10.1021/bi00417a043  1
1987 Michalopoulos GK, Eckl PM, Cruise JL, Novicki DL, Jirtle RL. Mechanisms of Rodent Liver Carcinogenesis Toxicology and Industrial Health. 3: 119-128. PMID 3303445 DOI: 10.1177/074823378700300209  1
1985 Thaler FJ, Michalopoulos GK. Hepatopoietin A: Partial Characterization and Trypsin Activation of a Hepatocyte Growth Factor Cancer Research. 45: 2545-2549. PMID 3157446  1
1985 Luetteke NC, Michalopoulos GK. Partial Purification and Characterization of a Hepatocyte Growth Factor Produced by Rat Hepatocellular Carcinoma Cells Cancer Research. 45: 6331-6337. PMID 2998598  1
1985 Cruise JL, Houck KA, Michalopoulos GK. Induction of DNA synthesis in cultured rat hepatocytes through stimulation of α1 adrenoreceptor by norepinephrine Science. 227: 749-751. PMID 2982212  1
1985 Luetteke NC, Houck KA, Thaler FJ, Michalopoulos GK. Stimulation of hepatocyte proliferation by protein factors derived from serum and hepatoma cells Proceedings of the American Association For Cancer Research 1
1984 Fuchs HE, Michalopoulos GK, Pizzo SV. Hepatocyte uptake of α1-proteinase inhibitor-trypsin complexes in vitro: Evidence for a shared uptake mechanism for proteinase complexes of α1-proteinase inhibitor and antithrombin III Journal of Cellular Biochemistry. 25: 231-243. PMID 6334690  1
1983 Levine SE, Budwit DA, Michalopoulos GK, Georgiade GS, McCarty KS. γ-Glutamyl transpeptidase activity in benign and malignant human mammary epithelial lesions. Histochemical evaluation Archives of Pathology and Laboratory Medicine. 107: 423-427. PMID 6135407  1
Show low-probability matches.