Paul B. Savage - Publications

Affiliations: 
Chemistry Brigham Young University, Provo, UT, United States 
Area:
Organic Chemistry

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hacioglu M, Oyardi O, Bozkurt-Guzel C, Savage PB. Antibiofilm activities of ceragenins and antimicrobial peptides against fungal-bacterial mono and multispecies biofilms. The Journal of Antibiotics. PMID 32203127 DOI: 10.1038/S41429-020-0299-0  0.349
2020 Bozkurt-Guzel C, Inci G, Oyardi O, Savage PB. Synergistic Activity of Ceragenins Against Carbapenem-Resistant Acinetobacter baumannii Strains in Both Checkerboard and Dynamic Time-Kill Assays. Current Microbiology. PMID 32189050 DOI: 10.1007/S00284-020-01949-W  0.348
2020 Dao A, Mills R, Kamble S, Savage PB, Little DG, Schindeler A. The application of ceragenins (CSAs) to orthopedic surgery and medicine. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 31994754 DOI: 10.1002/Jor.24615  0.333
2020 Wnorowska U, Fiedoruk K, Piktel E, Prasad SV, Sulik M, Janion M, Daniluk T, Savage PB, Bucki R. Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications. Journal of Nanobiotechnology. 18: 3. PMID 31898542 DOI: 10.1186/S12951-019-0566-Z  0.31
2019 Hacioglu M, Haciosmanoglu E, Birteksoz-Tan AS, Bozkurt-Guzel C, Savage PB. Effects of ceragenins and conventional antimicrobials on Candida albicans and Staphylococcus aureus mono and multispecies biofilms. Diagnostic Microbiology and Infectious Disease. 114863. PMID 31471074 DOI: 10.1016/J.Diagmicrobio.2019.06.014  0.354
2019 Ozbek-Celik B, Damar-Celik D, Mataraci-Kara E, Bozkurt-Guzel C, Savage PB. Comparative In Vitro Activities of First and Second-Generation Ceragenins Alone and in Combination with Antibiotics Against Multidrug-Resistant Strains. Antibiotics (Basel, Switzerland). 8. PMID 31461867 DOI: 10.3390/Antibiotics8030130  0.319
2019 Wnorowska U, Piktel E, Durnaś B, Fiedoruk K, Savage PB, Bucki R. Use of ceragenins as a potential treatment for urinary tract infections. Bmc Infectious Diseases. 19: 369. PMID 31046689 DOI: 10.1186/S12879-019-3994-3  0.324
2019 Hashemi MM, Holden BS, Coburn J, Taylor MF, Weber S, Hilton B, Zaugg AL, McEwan C, Carson R, Andersen JL, Price JC, Deng S, Savage PB. Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins. Frontiers in Microbiology. 10: 210. PMID 30833936 DOI: 10.3389/Fmicb.2019.00210  0.314
2019 Birteksoz-Tan AS, Zeybek Z, Hacioglu M, Savage PB, Bozkurt-Guzel C. In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila. The Journal of Antibiotics. PMID 30755738 DOI: 10.1038/S41429-019-0148-1  0.324
2018 Hashemi MM, Mmuoegbulam AO, Holden BS, Coburn J, Wilson J, Taylor MF, Reiley J, Baradaran D, Stenquist T, Deng S, Savage PB. Susceptibility of Multidrug-Resistant Bacteria, Isolated from Water and Plants in Nigeria, to Ceragenins. International Journal of Environmental Research and Public Health. 15. PMID 30563216 DOI: 10.3390/Ijerph15122758  0.344
2018 Schmid H, Schneidawind C, Jahnke S, Kettemann F, Secker KA, Duerr-Stoerzer S, Keppeler H, Kanz L, Savage PB, Schneidawind D. Culture-Expanded Human Invariant Natural Killer T Cells Suppress T-Cell Alloreactivity and Eradicate Leukemia. Frontiers in Immunology. 9: 1817. PMID 30127790 DOI: 10.3389/Fimmu.2018.01817  0.339
2018 Piktel E, Prokop I, Wnorowska U, Król G, Cieśluk M, Niemirowicz K, Savage PB, Bucki R. Ceragenin CSA-13 as free molecules and attached to magnetic nanoparticle surfaces induce caspase-dependent apoptosis in human breast cancer cells via disruption of cell oxidative balance. Oncotarget. 9: 21904-21920. PMID 29774111 DOI: 10.18632/Oncotarget.25105  0.313
2018 Mills R, Cheng TL, Mikulec K, Peacock L, Isaacs D, Genberg C, Savage PB, Little DG, Schindeler A. CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model. Clinical Orthopaedics and Related Research. PMID 29698291 DOI: 10.1097/01.Blo.0000533624.79802.E1  0.307
2018 Bozkurt-Guzel C, Hacioglu M, Savage PB. Investigation of the in vitro antifungal and antibiofilm activities of ceragenins CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 against Candida species. Diagnostic Microbiology and Infectious Disease. PMID 29680320 DOI: 10.1016/J.Diagmicrobio.2018.03.014  0.307
2018 Hashemi MM, Holden BS, Taylor MF, Wilson J, Coburn J, Hilton B, Nance T, Gubler S, Genberg C, Deng S, Savage PB. Antibacterial and Antifungal Activities of Poloxamer Micelles Containing Ceragenin CSA-131 on Ciliated Tissues. Molecules (Basel, Switzerland). 23. PMID 29518893 DOI: 10.3390/Molecules23030596  0.327
2018 Bucki R, Durnaś B, Wątek M, Piktel E, Cruz K, Wolak P, Savage PB, Janmey PA. Targeting polyelectrolyte networks in purulent body fluids to modulate bactericidal properties of some antibiotics. Infection and Drug Resistance. 11: 77-86. PMID 29391814 DOI: 10.2147/Idr.S145337  0.318
2018 Iweala OI, Savage PB, Commins SP. A Role for CD1d-restricted Invariant Natural Killer T Cells and Glycolipids in Alpha-Gal Allergy Journal of Allergy and Clinical Immunology. 141: AB288. DOI: 10.1016/J.Jaci.2017.12.918  0.318
2017 Durnaś B, Piktel E, Wątek M, Wollny T, Góźdź S, Smok-Kalwat J, Niemirowicz K, Savage PB, Bucki R. Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo. Bmc Microbiology. 17: 167. PMID 28747178 DOI: 10.1186/S12866-017-1075-6  0.328
2017 Pogoda K, Piktel E, Deptuła P, Savage PB, Lekka M, Bucki R. Stiffening of bacteria cells as a first manifestation of bactericidal attack. Micron (Oxford, England : 1993). 101: 95-102. PMID 28683405 DOI: 10.1016/J.Micron.2017.06.011  0.385
2017 Olekson MA, You T, Savage PB, Leung KP. Antimicrobial ceragenins inhibit biofilms and affect mammalian cell viability and migration in vitro. Febs Open Bio. 7: 953-967. PMID 28680809 DOI: 10.1002/2211-5463.12235  0.336
2017 Niemirowicz K, Durnaś B, Tokajuk G, Piktel E, Michalak G, Gu X, Kułakowska A, Savage PB, Bucki R. Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13. Scientific Reports. 7: 4610. PMID 28676673 DOI: 10.1038/S41598-017-04653-1  0.335
2017 Hashemi MM, Rovig J, Weber S, Hilton B, Forouzan MM, Savage PB. Susceptibility of colistin-resistant, Gram-negative bacteria to antimicrobial peptides and ceragenins. Antimicrobial Agents and Chemotherapy. PMID 28584137 DOI: 10.1128/Aac.00292-17  0.312
2017 Deng S, Kain L, Pereira CS, Mata S, Macedo MF, Bendelac A, Teyton L, Savage PB. Psychosine variants as antigens for natural killer T cells. Chemical Science. 8: 2204-2208. PMID 28507675 DOI: 10.1039/C6Sc04218J  0.343
2017 Piktel E, Pogoda K, Roman M, Niemirowicz K, Tokajuk G, Wróblewska M, Szynaka B, Kwiatek WM, Savage PB, Bucki R. Sporicidal activity of ceragenin CSA-13 against Bacillus subtilis. Scientific Reports. 7: 44452. PMID 28294162 DOI: 10.1038/Srep44452  0.334
2017 Polonskaya Z, Deng S, Sarkar A, Kain L, Comellas-Aragones M, McKay CS, Kaczanowska K, Holt M, McBride R, Palomo V, Self KM, Taylor S, Irimia A, Mehta SR, Dan JM, ... ... Savage PB, et al. T cells control the generation of nanomolar-affinity anti-glycan antibodies. The Journal of Clinical Investigation. PMID 28287405 DOI: 10.1172/Jci91192  0.32
2016 Li B, Siuta M, Bright V, Koktysh D, Matlock BK, Dumas ME, Zhu M, Holt A, Stec D, Deng S, Savage PB, Joyce S, Pham W. Improved proliferation of antigen-specific cytolytic T lymphocytes using a multimodal nanovaccine. International Journal of Nanomedicine. 11: 6103-6121. PMID 27895483 DOI: 10.2147/Ijn.S112432  0.305
2016 Niemirowicz K, Piktel E, Wilczewska AZ, Markiewicz KH, Durnaś B, Wątek M, Puszkarz I, Wróblewska M, Niklińska W, Savage PB, Bucki R. Core-shell magnetic nanoparticles display synergistic antibacterial effects against Pseudomonas aeruginosa and Staphylococcus aureus when combined with cathelicidin LL-37 or selected ceragenins. International Journal of Nanomedicine. 11: 5443-5455. PMID 27799768 DOI: 10.2147/Ijn.S113706  0.354
2016 Cruz Tleugabulova M, Escalante NK, Deng S, Fieve S, Ereño-Orbea J, Savage PB, Julien JP, Mallevaey T. Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming. Journal of Immunology (Baltimore, Md. : 1950). PMID 27798168 DOI: 10.4049/Jimmunol.1601382  0.334
2016 Durnaś B, Wnorowska U, Pogoda K, Deptuła P, Wątek M, Piktel E, Głuszek S, Gu X, Savage PB, Niemirowicz K, Bucki R. Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites. Plos One. 11: e0157242. PMID 27315208 DOI: 10.1371/Journal.Pone.0157242  0.375
2015 Bucki R, Niemirowicz K, Wnorowska U, Byfield FJ, Piktel E, Wątek M, Janmey PA, Savage PB. Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection. Antimicrobial Agents and Chemotherapy. 59: 6274-82. PMID 26248361 DOI: 10.1128/Aac.00653-15  0.367
2015 Kain L, Costanzo A, Webb B, Holt M, Bendelac A, Savage PB, Teyton L. Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides. Molecular Immunology. PMID 26141240 DOI: 10.1016/J.Molimm.2015.06.009  0.347
2015 Niemirowicz K, Prokop I, Wilczewska AZ, Wnorowska U, Piktel E, Wątek M, Savage PB, Bucki R. Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer cells. International Journal of Nanomedicine. 10: 3843-53. PMID 26082634 DOI: 10.2147/Ijn.S76104  0.325
2015 Niemirowicz K, Surel U, Wilczewska AZ, Mystkowska J, Piktel E, Gu X, Namiot Z, Ku?akowska A, Savage PB, Bucki R. Bactericidal activity and biocompatibility of ceragenin-coated magnetic nanoparticles. Journal of Nanobiotechnology. 13: 32. PMID 25929281 DOI: 10.1186/S12951-015-0093-5  0.333
2015 Wnorowska U, Niemirowicz K, Myint M, Diamond SL, Wróblewska M, Savage PB, Janmey PA, Bucki R. Bactericidal activities of cathelicidin LL-37 and select cationic lipids against the hypervirulent Pseudomonas aeruginosa strain LESB58. Antimicrobial Agents and Chemotherapy. 59: 3808-15. PMID 25870055 DOI: 10.1128/Aac.00421-15  0.325
2014 Bozkurt-Guzel C, Savage PB, Akcali A, Ozbek-Celik B. Potential synergy activity of the novel ceragenin, CSA-13, against carbapenem-resistant Acinetobacter baumannii strains isolated from bacteremia patients. Biomed Research International. 2014: 710273. PMID 24804236 DOI: 10.1155/2014/710273  0.324
2013 Anderson BL, Teyton L, Bendelac A, Savage PB. Stimulation of natural killer T cells by glycolipids. Molecules (Basel, Switzerland). 18: 15662-88. PMID 24352021 DOI: 10.3390/Molecules181215662  0.37
2013 Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells. Immunity. 39: 1032-42. PMID 24239091 DOI: 10.1016/J.Immuni.2013.11.001  0.339
2013 Chaudhary V, Albacker LA, Deng S, Chuang YT, Li Y, Umetsu DT, Savage PB. Synthesis of fungal glycolipid asperamide B and investigation of its ability to stimulate natural killer T cells. Organic Letters. 15: 5242-5. PMID 24111801 DOI: 10.1021/Ol4024375  0.571
2013 Bai L, Deng S, Reboulet R, Mathew R, Teyton L, Savage PB, Bendelac A. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proceedings of the National Academy of Sciences of the United States of America. 110: 16097-102. PMID 24043771 DOI: 10.1073/Pnas.1303218110  0.34
2013 Albacker LA, Chaudhary V, Chang YJ, Kim HY, Chuang YT, Pichavant M, DeKruyff RH, Savage PB, Umetsu DT. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nature Medicine. 19: 1297-304. PMID 23995283 DOI: 10.1038/Nm.3321  0.571
2013 Gu X, Jennings JD, Snarr J, Chaudhary V, Pollard JE, Savage PB. Optimization of ceragenins for prevention of bacterial colonization of hydrogel contact lenses. Investigative Ophthalmology & Visual Science. 54: 6217-23. PMID 23970466 DOI: 10.1167/Iovs.13-12664  0.548
2013 Nagant C, Pitts B, Stewart PS, Feng Y, Savage PB, Dehaye JP. Study of the effect of antimicrobial peptide mimic, CSA-13, on an established biofilm formed by Pseudomonas aeruginosa. Microbiologyopen. 2: 318-25. PMID 23436807 DOI: 10.1002/mbo3.77  0.459
2013 Leszczynska K, Namiot D, Byfield FJ, Cruz K, Zendzian-Piotrowska M, Fein DE, Savage PB, Diamond S, McCulloch CA, Janmey PA, Bucki R. Antibacterial activity of the human host defence peptide LL-37 and selected synthetic cationic lipids against bacteria associated with oral and upper respiratory tract infections. The Journal of Antimicrobial Chemotherapy. 68: 610-8. PMID 23134677 DOI: 10.1093/Jac/Dks434  0.344
2013 Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Crystal Structure of V delta 1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gamma delta T Cells. Immunity. 39: 1032-1042. DOI: 10.2210/Pdb4Mng/Pdb  0.316
2013 Zahoor R, Roohi S, Ahmad M, Iqbal Z, Amir N, Tariq S, Savage PB. Synthesis of 99mTc-cationic steroid antimicrobial-107 and in vitro evaluation Journal of Radioanalytical and Nuclear Chemistry. 295: 841-844. DOI: 10.1007/S10967-012-2016-3  0.319
2012 López-Sagaseta J, Kung JE, Savage PB, Gumperz J, Adams EJ. The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. Plos Biology. 10: e1001412. PMID 23109910 DOI: 10.1371/Journal.Pbio.1001412  0.342
2012 Freigang S, Landais E, Zadorozhny V, Kain L, Yoshida K, Liu Y, Deng S, Palinski W, Savage PB, Bendelac A, Teyton L. Scavenger receptors target glycolipids for natural killer T cell activation. The Journal of Clinical Investigation. 122: 3943-54. PMID 23064364 DOI: 10.1172/Jci62267  0.336
2012 Williams DL, Haymond BS, Beck JP, Savage PB, Chaudhary V, Epperson RT, Kawaguchi B, Bloebaum RD. In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection. Biomaterials. 33: 8641-56. PMID 22940221 DOI: 10.1016/J.Biomaterials.2012.08.003  0.532
2012 Pollard JE, Snarr J, Chaudhary V, Jennings JD, Shaw H, Christiansen B, Wright J, Jia W, Bishop RE, Savage PB. In vitro evaluation of the potential for resistance development to ceragenin CSA-13. The Journal of Antimicrobial Chemotherapy. 67: 2665-72. PMID 22899801 DOI: 10.1093/Jac/Dks276  0.58
2012 Bai L, Picard D, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR. European Journal of Immunology. 42: 2505-10. PMID 22829134 DOI: 10.1002/Eji.201242531  0.57
2012 Nagant C, Savage PB, Dehaye JP. Effect of pluronic acid F-127 on the toxicity towards eukaryotic cells of CSA-13, a cationic steroid analogue of antimicrobial peptides. Journal of Applied Microbiology. 112: 1173-83. PMID 22469097 DOI: 10.1111/J.1365-2672.2012.05297.X  0.337
2012 Lopez-Sagaseta J, Kung JE, Savage PB, Gumperz J, Adams EJ. The Molecular Basis for Recognition of CD1d/alpha-Galactosylceramide by a Human Non-Valpha24 T Cell Receptor Struct. Title Plos Biology. 10. DOI: 10.2210/Pdb4En3/Pdb  0.304
2011 Bozkurt-Guzel C, Savage PB, Gerceker AA. In vitro activities of the novel ceragenin CSA-13, alone or in combination with colistin, tobramycin, and ciprofloxacin, against Pseudomonas aeruginosa strains isolated from cystic fibrosis patients. Chemotherapy. 57: 505-10. PMID 22286090 DOI: 10.1159/000335588  0.325
2011 Byfield FJ, Kowalski M, Cruz K, Leszczy?ska K, Namiot A, Savage PB, Bucki R, Janmey PA. Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa Journal of Immunology. 187: 6402-6409. PMID 22095714 DOI: 10.4049/Jimmunol.1102185  0.371
2011 Scanlon ST, Thomas SY, Ferreira CM, Bai L, Krausz T, Savage PB, Bendelac A. Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation. The Journal of Experimental Medicine. 208: 2113-24. PMID 21930768 DOI: 10.1084/Jem.20110522  0.312
2011 Deng S, Mattner J, Zang Z, Bai L, Teyton L, Bendelac A, Savage PB. Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids. Organic & Biomolecular Chemistry. 9: 7659-62. PMID 21927724 DOI: 10.1039/C1Ob06276J  0.362
2011 Nagant C, Feng Y, Lucas B, Braeckmans K, Savage P, Dehaye JP. Effect of a low concentration of a cationic steroid antibiotic (CSA-13) on the formation of a biofilm by Pseudomonas aeruginosa. Journal of Applied Microbiology. 111: 763-72. PMID 21699631 DOI: 10.1111/J.1365-2672.2011.05085.X  0.486
2011 Chang YJ, Kim HY, Albacker LA, Lee HH, Baumgarth N, Akira S, Savage PB, Endo S, Yamamura T, Maaskant J, Kitano N, Singh A, Bhatt A, Besra GS, van den Elzen P, et al. Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. The Journal of Clinical Investigation. 121: 57-69. PMID 21157038 DOI: 10.1172/Jci44845  0.539
2011 Polat ZA, Savage PB, Genberg C. In vitro amoebicidal activity of a ceragenin, cationic steroid antibiotic-13, against Acanthamoeba castellanii and its cytotoxic potential. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. 27: 1-5. PMID 21142940 DOI: 10.1089/Jop.2010.0041  0.34
2011 Leszczy?ska K, Namiot A, Cruz K, Byfield FJ, Won E, Mendez G, Soko?owski W, Savage PB, Bucki R, Janmey PA. Potential of ceragenin CSA-13 and its mixture with pluronic F-127 as treatment of topical bacterial infections Journal of Applied Microbiology. 110: 229-238. PMID 20961363 DOI: 10.1111/J.1365-2672.2010.04874.X  0.329
2010 Lee HH, Meyer EH, Goya S, Pichavant M, Kim HY, Bu X, Umetsu SE, Jones JC, Savage PB, Iwakura Y, Casasnovas JM, Kaplan G, Freeman GJ, DeKruyff RH, Umetsu DT. Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. Journal of Immunology (Baltimore, Md. : 1950). 185: 5225-35. PMID 20889552 DOI: 10.4049/Jimmunol.1001116  0.33
2010 Braun NA, Mendez-Fernandez YV, Covarrubias R, Porcelli SA, Savage PB, Yagita H, Van Kaer L, Major AS. Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1758-65. PMID 20539017 DOI: 10.1161/Atvbaha.110.206045  0.347
2010 Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y, Savage PB, Bendelac A, Cravatt BF, Teyton L. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. The Journal of Clinical Investigation. 120: 1873-84. PMID 20484813 DOI: 10.1172/Jci40451  0.352
2010 Bucki R, Leszczynska K, Byfield FJ, Fein DE, Won E, Cruz K, Namiot A, Kulakowska A, Namiot Z, Savage PB, Diamond SL, Janmey PA. Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Antimicrobial Agents and Chemotherapy. 54: 2525-33. PMID 20308375 DOI: 10.1128/Aac.01682-09  0.371
2010 Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey DI, Savage PB, Knolle PA, Kolanus W, Förster I, Kurts C. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nature Immunology. 11: 313-20. PMID 20190758 DOI: 10.1038/Ni.1848  0.314
2010 Lara D, Feng Y, Bader J, Savage PB, Maldonado RA. Anti-trypanosomatid activity of ceragenins. The Journal of Parasitology. 96: 638-42. PMID 19958044 DOI: 10.1645/Ge-2329.1  0.539
2009 Morshed SR, Takahashi T, Savage PB, Kambham N, Strober S. Beta-galactosylceramide alters invariant natural killer T cell function and is effective treatment for lupus. Clinical Immunology (Orlando, Fla.). 132: 321-33. PMID 19564135 DOI: 10.1016/J.Clim.2009.05.018  0.318
2009 Howell MD, Streib JE, Kim BE, Lesley LJ, Dunlap AP, Geng D, Feng Y, Savage PB, Leung DY. Ceragenins: a class of antiviral compounds to treat orthopox infections. The Journal of Investigative Dermatology. 129: 2668-75. PMID 19516269 DOI: 10.1038/Jid.2009.120  0.484
2009 Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB, Bendelac A. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer. Proceedings of the National Academy of Sciences of the United States of America. 106: 10254-9. PMID 19506241 DOI: 10.1073/Pnas.0901228106  0.316
2009 Kim HY, Pichavant M, Matangkasombut P, Koh YI, Savage PB, DeKruyff RH, Umetsu DT. The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 3252-61. PMID 19234223 DOI: 10.4049/Jimmunol.0803339  0.307
2009 Yin N, Long X, Goff RD, Zhou D, Cantu C, Mattner J, Mezard PS, Teyton L, Bendelac A, Savage PB. Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells. Acs Chemical Biology. 4: 199-208. PMID 19175331 DOI: 10.1021/Cb800277N  0.754
2009 Farruggia G, Iotti S, Prodi L, Zaccheroni N, Montalti M, Savage PB, Andreani G, Trapani V, Wolf FI. A simple spectrofluorometric assay to measure total intracellular magnesium by a hydroxyquinoline derivative. Journal of Fluorescence. 19: 11-9. PMID 18528748 DOI: 10.1007/S10895-008-0374-6  0.335
2009 Pollard J, Wright J, Feng Y, Geng D, Genberg C, Savage PB. Activities of ceragenin CSA-13 against established biofilms in an in vitro model of catheter decolonization Anti-Infective Agents in Medicinal Chemistry. 8: 290-294. DOI: 10.2174/187152109789760225  0.503
2008 Epand RM, Epand RF, Savage PB. Ceragenins (cationic steroid compounds), a novel class of antimicrobial agents. Drug News & Perspectives. 21: 307-11. PMID 18836587 DOI: 10.1358/Dnp.2008.21.6.1246829  0.397
2008 Koh YI, Kim HY, Meyer EH, Pichavant M, Akbari O, Yasumi T, Savage PB, Dekruyff RH, Umetsu DT. Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 181: 4560-9. PMID 18802058 DOI: 10.4049/Jimmunol.181.7.4560  0.306
2008 Lai XZ, Feng Y, Pollard J, Chin JN, Rybak MJ, Bucki R, Epand RF, Epand RM, Savage PB. Ceragenins: cholic acid-based mimics of antimicrobial peptides. Accounts of Chemical Research. 41: 1233-40. PMID 18616297 DOI: 10.1021/Ar700270T  0.536
2008 Mattner J, Savage PB, Leung P, Oertelt SS, Wang V, Trivedi O, Scanlon ST, Pendem K, Teyton L, Hart J, Ridgway WM, Wicker LS, Gershwin ME, Bendelac A. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host & Microbe. 3: 304-15. PMID 18474357 DOI: 10.1016/J.Chom.2008.03.009  0.32
2008 Bucki R, Namiot DB, Namiot Z, Savage PB, Janmey PA. Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13. The Journal of Antimicrobial Chemotherapy. 62: 329-35. PMID 18456648 DOI: 10.1093/Jac/Dkn176  0.345
2008 Saha S, Savage PB, Bal M. Enhancement of the efficacy of erythromycin in multiple antibiotic-resistant gram-negative bacterial pathogens Journal of Applied Microbiology. 105: 822-828. PMID 18452533 DOI: 10.1111/J.1365-2672.2008.03820.X  0.354
2008 Matangkasombut P, Pichavant M, Yasumi T, Hendricks C, Savage PB, Dekruyff RH, Umetsu DT. Direct activation of natural killer T cells induces airway hyperreactivity in nonhuman primates. The Journal of Allergy and Clinical Immunology. 121: 1287-9. PMID 18355909 DOI: 10.1016/J.Jaci.2008.02.006  0.329
2008 Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L. Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids Journal of Molecular Biology. 377: 1104-1116. PMID 18295796 DOI: 10.1016/J.Jmb.2008.01.061  0.33
2008 Liu Y, Deng S, Bai L, Freigang S, Mattner J, Teyton L, Bendelac A, Savage PB. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties. Bioorganic & Medicinal Chemistry Letters. 18: 3052-5. PMID 18206371 DOI: 10.1016/J.Bmcl.2007.12.067  0.33
2008 Chin JN, Jones RN, Sader HS, Savage PB, Rybak MJ. Potential synergy activity of the novel ceragenin, CSA-13, against clinical isolates of Pseudomonas aeruginosa, including multidrug-resistant P. aeruginosa. The Journal of Antimicrobial Chemotherapy. 61: 365-70. PMID 18079128 DOI: 10.1093/Jac/Dkm457  0.322
2008 Bhat S, Savage P, Li C, Taotafa U, Ding B, Guan Q, Milner SM. 139
Antimicrobial Activity of Synthetic Cationic Steroids on Burn Wound Pathogens Wound Repair and Regeneration. 13: A28-A48. DOI: 10.1111/J.1067-1927.2005.130216Aq.X  0.748
2007 Long X, Deng S, Mattner J, Zang Z, Zhou D, McNary N, Goff RD, Teyton L, Bendelac A, Savage PB. Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids. Nature Chemical Biology. 3: 559-64. PMID 17660835 DOI: 10.1038/Nchembio.2007.19  0.728
2007 Epand RF, Savage PB, Epand RM. Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (Ceragenins). Biochimica Et Biophysica Acta. 1768: 2500-9. PMID 17599802 DOI: 10.1016/J.Bbamem.2007.05.023  0.363
2007 Schrantz N, Sagiv Y, Liu Y, Savage PB, Bendelac A, Teyton L. The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. The Journal of Experimental Medicine. 204: 841-52. PMID 17389239 DOI: 10.1084/Jem.20061562  0.32
2007 Chin JN, Rybak MJ, Cheung CM, Savage PB. Antimicrobial activities of ceragenins against clinical isolates of resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 51: 1268-73. PMID 17210765 DOI: 10.1128/Aac.01325-06  0.333
2007 Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annual Review of Immunology. 25: 297-336. PMID 17150027 DOI: 10.1146/Annurev.Immunol.25.022106.141711  0.361
2006 Savage PB, Teyton L, Bendelac A. Glycolipids for natural killer T cells. Chemical Society Reviews. 35: 771-9. PMID 16936925 DOI: 10.1039/B510638A  0.342
2006 Sagiv Y, Hudspeth K, Mattner J, Schrantz N, Stern RK, Zhou D, Savage PB, Teyton L, Bendelac A. Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein. Journal of Immunology (Baltimore, Md. : 1950). 177: 26-30. PMID 16785493 DOI: 10.4049/Jimmunol.177.1.26  0.311
2006 Campos-Martín Y, Colmenares M, Gozalbo-López B, López-Núñez M, Savage PB, Martínez-Naves E. Immature human dendritic cells infected with Leishmania infantum are resistant to NK-mediated cytolysis but are efficiently recognized by NKT cells. Journal of Immunology (Baltimore, Md. : 1950). 176: 6172-9. PMID 16670326 DOI: 10.4049/Jimmunol.176.10.6172  0.329
2006 Wei DG, Curran SA, Savage PB, Teyton L, Bendelac A. Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition. The Journal of Experimental Medicine. 203: 1197-207. PMID 16651387 DOI: 10.1084/Jem.20060418  0.356
2006 Liu Y, Goff RD, Zhou D, Mattner J, Sullivan BA, Khurana A, Cantu C, Ravkov EV, Ibegbu CC, Altman JD, Teyton L, Bendelac A, Savage PB. A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells. Journal of Immunological Methods. 312: 34-9. PMID 16647712 DOI: 10.1016/j.jim.2006.02.009  0.708
2006 Meyer EH, Goya S, Akbari O, Berry GJ, Savage PB, Kronenberg M, Nakayama T, DeKruyff RH, Umetsu DT. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 2782-7. PMID 16478801 DOI: 10.1073/Pnas.0510282103  0.354
2006 Mattner J, DeBord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, ... Savage PB, et al. Correction: Corrigendum: Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections Nature. 439: 502-502. DOI: 10.1038/Nature04475  0.752
2005 Kichler A, Leborgne C, Savage PB, Danos O. Cationic steroid antibiotics demonstrate DNA delivery properties. Journal of Controlled Release : Official Journal of the Controlled Release Society. 107: 174-82. PMID 16126297 DOI: 10.1016/J.Jconrel.2005.08.002  0.363
2005 Lua YY, Yang L, Pew CA, Zhang F, Fillmore WJ, Bronson RT, Sathyapalan A, Savage PB, Whittaker JD, Davis RC, Linford MR. Polyelectrolytes as new matrices for secondary ion mass spectrometry. Journal of the American Society For Mass Spectrometry. 16: 1575-82. PMID 16085420 DOI: 10.1016/J.Jasms.2005.05.007  0.501
2005 Zajonc DM, Cantu C, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nature Immunology. 6: 810-8. PMID 16007091 DOI: 10.1038/Ni1224  0.355
2005 Mattner J, Debord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, ... Savage PB, et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 434: 525-9. PMID 15791258 DOI: 10.1038/Nature03408  0.77
2005 Bronson RT, Michaelis DJ, Lamb RD, Husseini GA, Farnsworth PB, Linford MR, Izatt RM, Bradshaw JS, Savage PB. Efficient immobilization of a cadmium chemosensor in a thin film: generation of a cadmium sensor prototype. Organic Letters. 7: 1105-8. PMID 15760150 DOI: 10.1021/Ol050027T  0.477
2004 Zhou D, Mattner J, Cantu C, Schrantz N, Yin N, Gao Y, Sagiv Y, Hudspeth K, Wu YP, Yamashita T, Teneberg S, Wang D, Proia RL, Levery SB, Savage PB, et al. Lysosomal glycosphingolipid recognition by NKT cells. Science (New York, N.Y.). 306: 1786-9. PMID 15539565 DOI: 10.1126/Science.1103440  0.564
2004 Ding B, Yin N, Liu Y, Cardenas-Garcia J, Evanson R, Orsak T, Fan M, Turin G, Savage PB. Origins of cell selectivity of cationic steroid antibiotics. Journal of the American Chemical Society. 126: 13642-8. PMID 15493921 DOI: 10.1021/Ja046909P  0.574
2004 Goff RD, Gao Y, Mattner J, Zhou D, Yin N, Cantu C, Teyton L, Bendelac A, Savage PB. Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Journal of the American Chemical Society. 126: 13602-3. PMID 15493902 DOI: 10.1021/Ja045385Q  0.753
2004 Ding B, Taotofa U, Orsak T, Chadwell M, Savage PB. Synthesis and characterization of peptide-cationic steroid antibiotic conjugates. Organic Letters. 6: 3433-6. PMID 15387516 DOI: 10.1021/Ol048845T  0.381
2003 Cantu C, Benlagha K, Savage PB, Bendelac A, Teyton L. The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs. Journal of Immunology (Baltimore, Md. : 1950). 170: 4673-82. PMID 12707346 DOI: 10.4049/Jimmunol.170.9.4673  0.337
2003 Yin N, Marshall RL, Matheson S, Savage PB. Synthesis of lipid A derivatives and their interactions with polymyxin B and polymyxin B nonapeptide. Journal of the American Chemical Society. 125: 2426-35. PMID 12603130 DOI: 10.1021/Ja0284456  0.514
2002 Savage PB, Li C, Taotafa U, Ding B, Guan Q. Antibacterial properties of cationic steroid antibiotics. Fems Microbiology Letters. 217: 1-7. PMID 12445638 DOI: 10.1111/J.1574-6968.2002.Tb11448.X  0.766
2002 Bendelac A, Teyton L, Savage PB. Lipid presentation by CD1: the short and the long lipid story. Nature Immunology. 3: 421-2. PMID 11976717 DOI: 10.1038/Ni0502-421  0.3
2002 Zhou XT, Forestier C, Goff RD, Li C, Teyton L, Bendelac A, Savage PB. Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramides. Organic Letters. 4: 1267-70. PMID 11950339 DOI: 10.1021/Ol025565+  0.755
2002 Ding B, Guan Q, Walsh JP, Boswell JS, Winter TW, Winter ES, Boyd SS, Li C, Savage PB. Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics. Journal of Medicinal Chemistry. 45: 663-9. PMID 11806717 DOI: 10.1021/Jm0105070  0.556
2002 Chiu YH, Park SH, Benlagha K, Forestier C, Jayawardena-Wolf J, Savage PB, Teyton L, Bendelac A. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nature Immunology. 3: 55-60. PMID 11731798 DOI: 10.1038/Ni740  0.305
2002 Savage P. Cationic Steroid Antibiotics Current Medicinal Chemistry -Anti-Infective Agents. 1: 293-304. DOI: 10.2174/1568012023354776  0.332
2002 Savage PB. Design, synthesis and characterization of cationic peptide and steroid antibiotics European Journal of Organic Chemistry. 759-768. DOI: 10.1002/1099-0690(200203)2002:5<759::Aid-Ejoc759>3.0.Co;2-J  0.392
2001 Bronson RT, Bradshaw JS, Savage PB, Fuangswasdi S, Sang Chul Lee, Krakowiak KE, Izatt RM. Bis-8-hydroxyquinoline-armed diazatrithia-15-crown-5 and diazatrithia-16-crown-5 ligands: Possible fluorophoric metal ion sensors Journal of Organic Chemistry. 66: 4752-4758. PMID 11442399 DOI: 10.1021/Jo0017584  0.523
2001 Savage PB. Multidrug-resistant bacteria: Overcoming antibiotic permeability barriers of Gram-negative bacteria Annals of Medicine. 33: 167-171. PMID 11370769 DOI: 10.3109/07853890109002073  0.383
2001 Schmidt EJ, Boswell JS, Walsh JP, Schellenberg MM, Winter TW, Li C, Allman GW, Savage PB. Activities of cholic acid-derived antimicrobial agents against multidrug-resistant bacteria. The Journal of Antimicrobial Chemotherapy. 47: 671-4. PMID 11328782 DOI: 10.1093/Jac/47.5.671  0.536
2001 Song HC, Bradshaw JS, Chen YW, Xue GP, Chiara JA, Krakowiak KE, Savage PB, Xue ZL, Izatt RM. Syntheses of diazadithiacrown ethers containing two 8-hydroxyquinoline side arms Arkivoc. 2001: 25-35. DOI: 10.3998/Ark.5550190.0002.504  0.307
2001 Kawakami J, Bronson RT, Xue G, Bradshaw JS, Izatt RM, Savage PB. Characterization of bis-8-hydroxyquinoline-armed diazatrithia-16-crown-5 and diazadibenzo-18-crown-6 ligands as fluorescent chemosensors for zinc Journal of Supramolecular Chemistry. 1: 221-227. DOI: 10.1016/S1472-7862(02)00029-1  0.499
2000 Taotafa U, McMullin DB, Lee SC, Hansen LD, Savage PB. Anionic facial amphiphiles from cholic acid. Organic Letters. 2: 4117-20. PMID 11150178 DOI: 10.1021/Ol0064056  0.738
2000 Savage PB, Li C. Cholic acid derivatives: novel antimicrobials. Expert Opinion On Investigational Drugs. 9: 263-72. PMID 11060676 DOI: 10.1517/13543784.9.2.263  0.55
2000 Zhou XT, Rehman A, Li C, Savage PB. Preparation of a protected triamino analogue of cholic acid and sequential incorporation of amino acids in solution and on a solid support. Organic Letters. 2: 3015-8. PMID 10986096 DOI: 10.1021/Ol006336V  0.485
2000 Guan Q, Li C, Schmidt EJ, Boswell JS, Walsh JP, Allman GW, Savage PB. Preparation and characterization of cholic acid-derived antimicrobial agents with controlled stabilities. Organic Letters. 2: 2837-40. PMID 10964378 DOI: 10.1021/ol0062704  0.475
1999 Yang Z, Bradshaw JS, Zhang XX, Savage PB, Krakowiak KE, Dalley NK, Su N, Bronson RT, Izatt RM. New Tetraazacrown Ethers Containing Two Pyridine, Quinoline, 8-Hydroxyquinoline, or 8-Aminoquinoline Sidearms. The Journal of Organic Chemistry. 64: 3162-3170. PMID 11674416 DOI: 10.1021/Jo982292G  0.474
1999 Li C, Lewis MR, Gilbert AB, Noel MD, Scoville DH, Allman GW, Savage PB. Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives. Antimicrobial Agents and Chemotherapy. 43: 1347-9. PMID 10348750 DOI: 10.1128/Aac.43.6.1347  0.547
1999 Li C, Budge LP, Driscoll CD, Willardson BM, Allman GW, Savage PB. Incremental conversion of outer-membrane permeabilizers into potent antibiotics for gram-negative bacteria Journal of the American Chemical Society. 121: 931-940. DOI: 10.1021/Ja982938M  0.541
1999 Li C, Atiq-ur-Rehman, Dalley NK, Savage PB. Short syntheses of triamine derivatives of cholic acid Tetrahedron Letters. 40: 1861-1864. DOI: 10.1016/S0040-4039(99)00076-3  0.46
1999 Atiq-ur-Rehman, Li C, Budge LP, Street SE, Savage PB. Preparation of amino acid-appended cholic acid derivatives as sensitizers of Gram-negative bacteria Tetrahedron Letters. 40: 1865-1868. DOI: 10.1016/S0040-4039(99)00075-1  0.487
1998 Li C, Peters AS, Meredith EL, Allman GW, Savage PB. Design and Synthesis of Potent Sensitizers of Gram-Negative Bacteria Based on a Cholic Acid Scaffolding Journal of the American Chemical Society. 120: 2961-2962. DOI: 10.1021/Ja973881R  0.501
1997 Bordunov AV, Bradshaw JS, Pastushok VN, Zhang XX, Kou X, Dalley NK, Yang Z, Savage PB, Izatt RM. Azacrown ethers containing oximic an Schiff base sidearms - Potential heteronuclear metal ion receptors Tetrahedron. 53: 17595-17606. DOI: 10.1016/S0040-4020(97)10229-0  0.301
1997 Holmgren SK, Savage PB, Desper JM, Schladetzky KD, Powell DR, Gellman SH. Steric control of oxidation selectivity in macrycyclic phosphine oxide-dithioethers Tetrahedron. 53: 12249-12262. DOI: 10.1016/S0040-4020(97)00557-7  0.432
1994 Savage PB, Holmgren SK, Gellman SH. Anion and ion pair complexation by a macrocyclic phosphine oxide disulfoxide Journal of the American Chemical Society. 116: 4069-4070. DOI: 10.1021/Ja00088A049  0.444
1993 Savage PB, Holmgren SK, Desper JM, Gellman SH. Macrocycles containing sulfur and phosphorus: Structure and complexation properties Pure and Applied Chemistry. 65: 461-466. DOI: 10.1351/Pac199365030461  0.455
1993 Savage PB, Gellman SH. Complexation of hexosammonium ions: evidence for contributions from OH.cntdot..cntdot..cntdot.OH hydrogen bonds in a hydroxylic medium Journal of the American Chemical Society. 115: 10448-10449. DOI: 10.1021/Ja00075A106  0.435
1993 Savage PB, Holmgren SK, Gellman SH. Optimization of a phosphine oxide disulfoxide array for multipoint hydrogen bonding to ammonium ions Journal of the American Chemical Society. 115: 7900-7901. DOI: 10.1021/Ja00070A055  0.423
1992 Savage PB, Desper JM, Gellman SH. Stereoselective oxidation of an eleven-membered heterocycle Tetrahedron Letters. 33: 2107-2110. DOI: 10.1016/0040-4039(92)88152-U  0.437
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