| Year |
Citation |
Score |
| 2020 |
Gmeiner WH. Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine. Molecules. 25: 3438. PMID 32751071 DOI: 10.3390/Molecules25153438 |
0.355 |
|
| 2020 |
Gmeiner WH, Miller LD, Chou JW, Dominijanni A, Mutkus L, Marini F, Ruiz J, Dotson T, Thomas KW, Parks G, Bellinger CR. Dysregulated Pyrimidine Biosynthesis Contributes to 5-FU Resistance in SCLC Patient-Derived Organoids but Response to a Novel Polymeric Fluoropyrimidine, CF10. Cancers. 12. PMID 32224870 DOI: 10.3390/Cancers12040788 |
0.32 |
|
| 2020 |
Thaker S, Gmeiner WH, Ji P, Zabaleta J, Reyes T, DiGiovanni M, Wang X, Williams JL. Abstract 1842: F10 and 5-fluorouracil: Chemotherapeutic potential of F10 in alleviating colon cancer racial health disparity Cancer Research. 80: 1842-1842. DOI: 10.1158/1538-7445.Am2020-1842 |
0.32 |
|
| 2019 |
Mani C, Gmeiner W, Palle K. Abstract 2087: Mechanistic studies reveal novel molecular insights on anticancer properties of F10 compound in human colon cancer cells Cancer Research. 79: 2087-2087. DOI: 10.1158/1538-7445.Sabcs18-2087 |
0.4 |
|
| 2019 |
Gmeiner WH, Manandhar M, Hinds AM, Holmes J, Vidi P, Tsunoda T, Shirasawa S. Abstract 2079: Enhanced potency of the polymeric fluoropyrimidine CF10 to KRAS-mutant colorectal cancer cells Cancer Research. 79: 2079-2079. DOI: 10.1158/1538-7445.Am2019-2079 |
0.336 |
|
| 2018 |
Mani C, Pai S, Papke CM, Palle K, Gmeiner WH. Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition. Neoplasia (New York, N.Y.). 20: 1236-1245. PMID 30439567 DOI: 10.1016/J.Neo.2018.10.006 |
0.349 |
|
| 2017 |
Melvin RL, Thompson WG, Godwin RC, Gmeiner WH, Salsbury FR. MutS's Multi-Domain Allosteric Response to Three DNA Damage Types Revealed by Machine Learning. Frontiers in Physics. 5. PMID 31938712 DOI: 10.3389/Fphy.2017.00010 |
0.356 |
|
| 2017 |
Ghosh S, Mallick S, Das U, Verma A, Pal U, Chatterjee S, Nandy A, Saha KD, Maiti NC, Baishya B, Suresh Kumar G, Gmeiner WH. Curcumin stably interacts with DNA hairpin through minor groove binding and demonstrates enhanced cytotoxicity in combination with FdU nucleotides. Biochimica Et Biophysica Acta. PMID 29107813 DOI: 10.1016/J.Bbagen.2017.10.018 |
0.404 |
|
| 2017 |
Godwin RC, Gmeiner WH, Salsbury FR. All-atom molecular dynamics comparison of disease-associated zinc fingers. Journal of Biomolecular Structure & Dynamics. 1-14. PMID 28814200 DOI: 10.1080/07391102.2017.1363662 |
0.3 |
|
| 2017 |
Melvin RL, Gmeiner WH, Salsbury FR. All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer. Physical Chemistry Chemical Physics : Pccp. PMID 28805211 DOI: 10.1039/C7Cp03479B |
0.32 |
|
| 2017 |
Melvin RL, Gmeiner WH, Salsbury FR. All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic. The Journal of Physical Chemistry. B. 121: 7803-7812. PMID 28745046 DOI: 10.1021/Acs.Jpcb.7B04724 |
0.342 |
|
| 2017 |
Godwin RC, Melvin RL, Gmeiner WH, Salsbury FR. Binding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-κB Essential Modulator). Biochemistry. 56: 623-633. PMID 28035815 DOI: 10.1021/Acs.Biochem.6B00755 |
0.322 |
|
| 2017 |
Gmeiner WH, Dominijanni A, Boyacioglu O, Forsyth S, Skardal A, Pasche B. Abstract 1214: The polymeric fluoropyrimidine F10 is effective towards cell and organoid models of 5-FU-resistant colorectal cancer Cancer Research. 77: 1214-1214. DOI: 10.1158/1538-7445.Am2017-1214 |
0.379 |
|
| 2016 |
Stuart CH, Riley KR, Boyacioglu O, Herpai DM, Debinski W, Qasem S, Marini FC, Colyer CL, Gmeiner WH. Selection of a Novel Aptamer Against Vitronectin Using Capillary Electrophoresis and Next Generation Sequencing. Molecular Therapy. Nucleic Acids. 5: e386. PMID 27845768 DOI: 10.1038/Mtna.2016.91 |
0.316 |
|
| 2016 |
Melvin RL, Gmeiner WH, Salsbury FR. All-Atom Molecular Dynamics Reveals Mechanism of Zinc Complexation with Therapeutic F10. The Journal of Physical Chemistry. B. 120: 10269-10279. PMID 27606431 DOI: 10.1021/Acs.Jpcb.6B07753 |
0.348 |
|
| 2016 |
Gmeiner WH, Debinski W, Milligan C, Caudell D, Pardee TS. The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence. Future Oncology (London, England). PMID 27279153 DOI: 10.2217/Fon-2016-0091 |
0.317 |
|
| 2016 |
Yoho J, Wogensthal K, Bennett TL, Palmer J, Comfort KK, Kango-Singh M, Swavey S, Stuart CH, Gmeiner WH. Water-Soluble Zinc Porphyrin Capable of Light-Induced Photocleavage of DNA: Cell Localization Studies inDrosophila Melanogasterand Light Activated Treatment of Lung Cancer Cells European Journal of Inorganic Chemistry. 2017: 153-159. DOI: 10.1002/Ejic.201601077 |
0.351 |
|
| 2015 |
Gmeiner WH, Boyacioglu O, Stuart CH, Jennings-Gee J, Balaji KC. The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 Towards prostate cancer cells are enhanced by Zn2+-chelation and inhibiting the serine protease Omi/HtrA2 Prostate. 75: 360-369. PMID 25408502 DOI: 10.1002/Pros.22922 |
0.304 |
|
| 2014 |
Pardee TS, Stadelman K, Jennings-Gee J, Caudell DL, Gmeiner WH. The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells. Oncotarget. 5: 4170-9. PMID 24961587 DOI: 10.18632/Oncotarget.1937 |
0.309 |
|
| 2014 |
Ghosh S, Ucer KB, D'Agostino R, Grant K, Sirintrapun J, Thomas MJ, Hantgan R, Bharadwaj M, Gmeiner WH. Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity. Nanomedicine : Nanotechnology, Biology, and Medicine. 10: 451-61. PMID 23988714 DOI: 10.1016/J.Nano.2013.07.019 |
0.379 |
|
| 2013 |
Boyacioglu O, Stuart CH, Kulik G, Gmeiner WH. Dimeric DNA Aptamer Complexes for High-capacity-targeted Drug Delivery Using pH-sensitive Covalent Linkages. Molecular Therapy. Nucleic Acids. 2: e107. PMID 23860551 DOI: 10.1038/Mtna.2013.37 |
0.361 |
|
| 2013 |
Huang SY, Murai J, Dalla Rosa I, Dexheimer TS, Naumova A, Gmeiner WH, Pommier Y. TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs. Nucleic Acids Research. 41: 7793-803. PMID 23775789 DOI: 10.1093/Nar/Gkt483 |
0.333 |
|
| 2013 |
Wu SY, Chen TM, Gmeiner WH, Chu E, Schmitz JC. Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity. Nucleic Acids Research. 41: 4650-9. PMID 23449220 DOI: 10.1093/Nar/Gkt120 |
0.356 |
|
| 2013 |
Ghosh S, Salsbury FR, Horita DA, Gmeiner WH. Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA. Journal of Biomolecular Structure & Dynamics. 31: 1301-10. PMID 23153072 DOI: 10.1080/07391102.2012.732343 |
0.382 |
|
| 2013 |
Jennings-Gee J, Pardee TS, Gmeiner WH. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Experimental Hematology. 41: 180-188.e4. PMID 23085462 DOI: 10.1016/J.Exphem.2012.10.007 |
0.364 |
|
| 2013 |
Pardee T, Jennings-Gee J, Stadelman K, Caudell DL, Gmeiner W. The Poison Oligonucleotide F10 Is Efficiently Taken Up By, and Highly Effective Against, Acute Lymphoblastic Leukemia While Sparing Normal Hematopoietic Cells Blood. 122: 2674-2674. DOI: 10.1182/Blood.V122.21.2674.2674 |
0.323 |
|
| 2013 |
Gmeiner WH, Ghosh S, Ucer KB, Williams RT, D'Agostino R, Grant K, Sirintrapun J, Thomas M, Hantgan R, Bharadwaj M. Abstract LB-6: Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with pH-dependent DNA release and anti-tumor activity. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-6 |
0.377 |
|
| 2013 |
Huang SN, Murai J, Rosa ID, Dexheimer TS, Gmeiner WH, Pommier Y. Abstract C79: TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C79 |
0.344 |
|
| 2012 |
Pardee TS, Gomes E, Jennings-Gee J, Caudell D, Gmeiner WH. Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity. Blood. 119: 3561-70. PMID 22362039 DOI: 10.1182/Blood-2011-06-362442 |
0.312 |
|
| 2012 |
Pardee T, Jennings-Gee J, Alexander P, Gmeiner W. Thymidylate Synthase Inhibition with the Novel Fluoropyrimidine FdUMP[10] Is Highly Effective Against Acute Lymphoblastic Leukemia Blood. 120: 1505-1505. DOI: 10.1182/Blood.V120.21.1505.1505 |
0.329 |
|
| 2011 |
Gmeiner WH, Salsbury F, Olsen CM, Marky LA. The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs. Journal of Nucleic Acids. 2011: 631372. PMID 21904666 DOI: 10.4061/2011/631372 |
0.374 |
|
| 2011 |
Ghosh S, Salsbury FR, Horita DA, Gmeiner WH. Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif. Nucleic Acids Research. 39: 4490-8. PMID 21296761 DOI: 10.1093/Nar/Gkr029 |
0.385 |
|
| 2010 |
Pardee T, Gomes E, Jennings-Gee J, Caudell DL, Gmeiner W. The Novel Fluoropyrimidine FdUMP[10] Is Highly Active Against Acute Myeloid Leukemia Blood. 116: 3302-3302. DOI: 10.1182/Blood.V116.21.3302.3302 |
0.307 |
|
| 2009 |
Ghosh S, Dutta S, Gomes E, Carroll D, D'Agostino R, Olson J, Guthold M, Gmeiner WH. Increased heating efficiency and selective thermal ablation of malignant tissue with DNA-encased multiwalled carbon nanotubes. Acs Nano. 3: 2667-73. PMID 19655728 DOI: 10.1021/Nn900368B |
0.306 |
|
| 2005 |
Liao ZY, Sordet O, Zhang HL, Kohlhagen G, Antony S, Gmeiner WH, Pommier Y. A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes Cancer Research. 65: 4844-4851. PMID 15930305 DOI: 10.1158/0008-5472.Can-04-1302 |
0.368 |
|
| 2005 |
Gmeiner WH. Novel chemical strategies for thymidylate synthase inhibition. Current Medicinal Chemistry. 12: 191-202. PMID 15638735 DOI: 10.2174/0929867053363432 |
0.304 |
|
| 2004 |
Mao XA, Marky LA, Gmeiner WH. NMR structure of the thrombin-binding DNA aptamer stabilized by Sr 2+ Journal of Biomolecular Structure and Dynamics. 22: 25-33. PMID 15214802 DOI: 10.1080/07391102.2004.10506977 |
0.332 |
|
| 2004 |
Gmeiner WH, Trump E, Wei C. Enhanced DNA-directed effects of FdUMP[10] compared to 5FU. Nucleosides, Nucleotides & Nucleic Acids. 23: 401-10. PMID 15043163 DOI: 10.1081/Ncn-120028336 |
0.322 |
|
| 2003 |
Gmeiner WH, Yu S, Pon RT, Pourquier P, Pommier Y. Structural basis for topoisomerase I inhibition by nucleoside analogs. Nucleosides, Nucleotides & Nucleic Acids. 22: 653-8. PMID 14565246 DOI: 10.1081/Ncn-120022604 |
0.401 |
|
| 2002 |
Comolli LR, Ulyanov NB, Soto AM, Marky LA, James TL, Gmeiner WH. NMR structure of the 3' stem-loop from human U4 snRNA. Nucleic Acids Research. 30: 4371-9. PMID 12384583 DOI: 10.1093/Nar/Gkf560 |
0.312 |
|
| 2002 |
Gmeiner WH. Antimetabolite incorporation into DNA: structural and thermodynamic basis for anticancer activity. Biopolymers. 65: 180-9. PMID 12228923 DOI: 10.1002/Bip.10214 |
0.377 |
|
| 2002 |
Liu C, Willingham M, Liu J, Gmeiner WH. Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts. International Journal of Oncology. 21: 303-8. PMID 12118325 DOI: 10.3892/Ijo.21.2.303 |
0.303 |
|
| 2002 |
Soto AM, Gmeiner WH, Marky LA. Energetic and conformational contributions to the stability of Okazaki fragments. Biochemistry. 41: 6842-9. PMID 12022889 DOI: 10.1021/Bi025715O |
0.374 |
|
| 2002 |
Cui W, Gmeiner WH. Effect of 5-FU substitution and mutation on Sm protein binding to human U4 snRNA Nucleosides, Nucleotides and Nucleic Acids. 21: 139-154. PMID 11991141 DOI: 10.1081/Ncn-120003178 |
0.311 |
|
| 2002 |
Gmeiner WH. The structure and dynamics of the U4/U6 snRNP: implications for pre-mRNA splicing and use as a model system to investigate the RNA-mediated effects of (5F)Ura. Journal of Biomolecular Structure & Dynamics. 19: 853-62. PMID 11922840 DOI: 10.1080/07391102.2002.10506789 |
0.334 |
|
| 2002 |
Konerding D, James TL, Trump E, Soto AM, Marky LA, Gmeiner WH. NMR structure of a gemcitabine-substituted model Okazaki fragment. Biochemistry. 41: 839-46. PMID 11790105 DOI: 10.1021/Bi015678L |
0.383 |
|
| 2001 |
Liu J, Kolar C, Lawson TA, Gmeiner WH. Targeted drug delivery to chemoresistant cells: Folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-fu-resistant human colorectal tumor cells Journal of Organic Chemistry. 66: 5655-5663. PMID 11511236 DOI: 10.1021/Jo005757N |
0.311 |
|
| 2000 |
Guo J, Daizadeh I, Gmeiner WH. Structure of the Sm binding site from human U4 snRNA derived from a 3 ns PME molecular dynamics simulation. Journal of Biomolecular Structure & Dynamics. 18: 335-344. PMID 11149510 DOI: 10.1080/07391102.2000.10506670 |
0.309 |
|
| 2000 |
Gmeiner WH, Cui W, Sharma S, Soto AM, Marky LA, Lown JW. Shape-selective binding of geometrically-constrained bis-distamycins to a DNA duplex and a model Okazaki fragment of identical sequence Nucleosides, Nucleotides and Nucleic Acids. 19: 1365-1379. PMID 11097065 DOI: 10.1080/15257770008033058 |
0.314 |
|
| 1999 |
Gmeiner WH, Cui W, Konerding DE, Keifer PA, Sharma SK, Soto AM, Marky LA, Lown JW. Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins Journal of Biomolecular Structure and Dynamics. 17: 507-518. PMID 10636085 DOI: 10.1080/07391102.1999.10508381 |
0.36 |
|
| 1999 |
Liu J, Kolath J, Anderson J, Kolar C, Lawson TA, Talmadge J, Gmeiner WH. Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation Antisense and Nucleic Acid Drug Development. 9: 481-486. PMID 10555156 DOI: 10.1089/Oli.1.1999.9.481 |
0.327 |
|
| 1999 |
Liu J, Skradis A, Kolar C, Kolath J, Anderson J, Lawson T, Talmadge J, Gmeiner WH. Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU Nucleosides and Nucleotides. 18: 1789-1802. PMID 10478484 DOI: 10.1080/07328319908044843 |
0.304 |
|
| 1999 |
Gmeiner WH, Skradis A, Pon RT, Liu J. Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP. Nucleosides, Nucleotides & Nucleic Acids. 18: 1729-1730. PMID 10474257 DOI: 10.1080/07328319908044836 |
0.319 |
|
| 1999 |
Gmeiner WH, Konerding D, James TL. Effect of cytarabine on the NMR structure of a model okazaki fragment from the SV40 genome. Biochemistry. 38: 1166-75. PMID 9930976 DOI: 10.1021/Bi981702S |
0.383 |
|
| 1998 |
Gmeiner WH, Skradis A, Pon RT, Liu J. Cytarabine-induced destabilization of a model Okazaki fragment. Nucleic Acids Research. 26: 2359-2365. PMID 9580686 DOI: 10.1093/Nar/26.10.2359 |
0.367 |
|
| 1997 |
Sahasrabudhe PV, Gmeiner WH. Solution structures of 5-fluorouracil-substituted RNA duplexes containing G-U wobble base pairs. Biochemistry. 36: 5981-5991. PMID 9166768 DOI: 10.1021/Bi9700577 |
0.308 |
|
| 1996 |
Sahasrabudhe PV, Pon RT, Gmeiner WH. Solution structures of 5-fluorouracil-substituted DNA and RNA decamer duplexes. Biochemistry. 35: 13597-13608. PMID 8885839 DOI: 10.1021/Bi960535Y |
0.361 |
|
| 1995 |
Sahasrabudhe PV, Pon RT, Gmeiner WH. Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA Nucleic Acids Research. 23: 3916-3921. PMID 7479036 DOI: 10.1093/Nar/23.19.3916 |
0.354 |
|
| 1994 |
Gmeiner WH, Anderson J, Sahasrabudhe P. NMR Studies Show Monomeric 5-Fluorouridine Forms Base Pairs of Increased Stability Compared with Uridine in Non-Aqueous Solvents Nucleosides, Nucleotides & Nucleic Acids. 13: 2329-2344. DOI: 10.1080/15257779408013224 |
0.342 |
|
| 1994 |
Gmeiner WH, Sahasrabudhe P, Pon RT. Synthesis of 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine 3'-(Cyanoethyl N,N-diisopropylphosphoramidite) and Its Use in the Synthesis of RNA Journal of Organic Chemistry. 59: 5779-5783. DOI: 10.1021/Jo00098A044 |
0.305 |
|
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