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Beshay N. Zordoky, Ph.D. - Publications

Affiliations: 
2012 University of Alberta, Edmonton, Alberta, Canada 
Area:
Pharmaceutical Chemistry, Physiology Biology
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34/56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Liu J, Curtin C, Lall R, Lane S, Wieke J, Ariza A, Sejour L, Vlachos I, Zordoky BN, Peterson RT, Asnani A. Inhibition of Cyp1a Protects Mice against Anthracycline Cardiomyopathy. Biorxiv : the Preprint Server For Biology. PMID 38645084 DOI: 10.1101/2024.04.10.588915  0.37
2024 Abdelgawad IY, George B, Grant MKO, Huang Y, Shan Y, Huang RS, Zordoky BN. Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice. Archives of Toxicology. PMID 38244039 DOI: 10.1007/s00204-023-03678-y  0.358
2022 Agostinucci K, Grant MKO, Seelig D, Yücel D, van Berlo J, Bartolomucci A, Dyck JRB, Zordoky BN. Divergent Cardiac Effects of Angiotensin II and Isoproterenol Following Juvenile Exposure to Doxorubicin. Frontiers in Cardiovascular Medicine. 9: 742193. PMID 35402534 DOI: 10.3389/fcvm.2022.742193  0.332
2020 Grant MKO, Abdelgawad IY, Lewis CA, Seelig D, Zordoky BN. Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction. Plos One. 15: e0232507. PMID 32645007 DOI: 10.1371/Journal.Pone.0232507  0.418
2020 Grant MKO, Abdelgawad IY, Lewis CA, Zordoky BN. Sexual Dimorphism in Doxorubicin-induced Systemic Inflammation: Implications for Hepatic Cytochrome P450 Regulation. International Journal of Molecular Sciences. 21. PMID 32074957 DOI: 10.3390/Ijms21041279  0.4
2019 Grant MKO, Seelig DM, Sharkey LC, Choi WSV, Abdelgawad IY, Zordoky BN. Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice. Plos One. 14: e0212486. PMID 30785938 DOI: 10.1371/Journal.Pone.0212486  0.389
2018 Matsumura N, Zordoky BN, Robertson IM, Hamza SM, Parajuli N, Soltys CM, Beker DL, Grant MK, Razzoli M, Bartolomucci A, Dyck JRB. Co-administration of resveratrol with doxorubicin in young mice attenuates detrimental late-occurring cardiovascular changes. Cardiovascular Research. PMID 29566148 DOI: 10.1093/Cvr/Cvy064  0.328
2017 Grant MK, Seelig DM, Sharkey LC, Zordoky BN. Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice. Biology of Sex Differences. 8: 1. PMID 28078076 DOI: 10.1186/S13293-016-0124-4  0.526
2015 Sung MM, Zordoky BN, Bujak AL, Lally JS, Fung D, Young ME, Horman S, Miller EJ, Light PE, Kemp BE, Steinberg GR, Dyck JR. AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism. Cardiovascular Research. 107: 235-45. PMID 26023060 DOI: 10.1093/Cvr/Cvv166  0.44
2015 Zordoky BN, Sung MM, Ezekowitz J, Mandal R, Han B, Bjorndahl TC, Bouatra S, Anderson T, Oudit GY, Wishart DS, Dyck JR. Metabolomic fingerprint of heart failure with preserved ejection fraction. Plos One. 10: e0124844. PMID 26010610 DOI: 10.1371/Journal.Pone.0124844  0.369
2013 Dolinsky VW, Chakrabarti S, Pereira TJ, Oka T, Levasseur J, Beker D, Zordoky BN, Morton JS, Nagendran J, Lopaschuk GD, Davidge ST, Dyck JR. Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice. Biochimica Et Biophysica Acta. 1832: 1723-33. PMID 23707558 DOI: 10.1016/J.Bbadis.2013.05.018  0.378
2013 Nagendran J, Kienesberger PC, Pulinilkunnil T, Zordoky BN, Sung MM, Kim T, Young ME, Dyck JR. Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female mice. Heart (British Cardiac Society). 99: 1041-7. PMID 23704323 DOI: 10.1136/Heartjnl-2013-303843  0.565
2013 Dolinsky VW, Rogan KJ, Sung MM, Zordoky BN, Haykowsky MJ, Young ME, Jones LW, Dyck JR. Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. American Journal of Physiology. Endocrinology and Metabolism. 305: E243-53. PMID 23695218 DOI: 10.1152/Ajpendo.00044.2013  0.369
2013 Alsaad AM, Zordoky BN, Tse MM, El-Kadi AO. Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy. Drug Metabolism Reviews. 45: 173-95. PMID 23600686 DOI: 10.3109/03602532.2012.754460  0.598
2013 Anwar-Mohamed A, El-Sherbeni A, Kim SH, Elshenawy OH, Althurwi HN, Zordoky BN, El-Kadi AO. Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 719-29. PMID 23409951 DOI: 10.3109/00498254.2012.754113  0.622
2013 Althurwi HN, Tse MM, Abdelhamid G, Zordoky BN, Hammock BD, El-Kadi AO. Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy. British Journal of Pharmacology. 168: 1794-807. PMID 23176298 DOI: 10.1111/Bph.12066  0.647
2013 El-Sherbeni AA, Aboutabl ME, Zordoky BN, Anwar-Mohamed A, El-Kadi AO. Determination of the dominant arachidonic acid cytochrome p450 monooxygenases in rat heart, lung, kidney, and liver: protein expression and metabolite kinetics. The Aaps Journal. 15: 112-22. PMID 23139020 DOI: 10.1208/S12248-012-9425-7  0.782
2013 Chaudhary KR, Zordoky BN, Edin ML, Alsaleh N, El-Kadi AO, Zeldin DC, Seubert JM. Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. Prostaglandins & Other Lipid Mediators. 104: 8-17. PMID 22922020 DOI: 10.1016/j.prostaglandins.2012.08.001  0.528
2013 Dolinsky VW, Chakrabarti S, Pereira TJ, Oka T, Zordoky BN, Morton JS, Nagendran J, Opaschuk GD, Davidge ST, Dyck JR. Resveratrol Prevents Hypertension and Cardiac Hypertrophy in Hypertensive Rodents Canadian Journal of Diabetes. 37: S23. DOI: 10.1016/J.Jcjd.2013.08.070  0.332
2012 Alsaad AM, Zordoky BN, El-Sherbeni AA, El-Kadi AO. Chronic doxorubicin cardiotoxicity modulates cardiac cytochrome P450-mediated arachidonic acid metabolism in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2126-35. PMID 22867862 DOI: 10.1124/dmd.112.046631  0.74
2012 Anwar-Mohamed A, El-Sherbeni AA, Kim SH, Althurwi HN, Zordoky BN, El-Kadi AO. Acute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl/6 mouse heart. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 42: 1235-47. PMID 22680237 DOI: 10.3109/00498254.2012.693971  0.72
2011 Zordoky BN, Anwar-Mohamed A, Aboutabl ME, El-Kadi AO. Acute doxorubicin toxicity differentially alters cytochrome P450 expression and arachidonic acid metabolism in rat kidney and liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1440-50. PMID 21571947 DOI: 10.1124/Dmd.111.039123  0.798
2011 Aboutabl ME, Zordoky BN, Hammock BD, El-Kadi AO. Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene. Journal of Cardiovascular Pharmacology. 57: 273-81. PMID 21383588 DOI: 10.1097/Fjc.0B013E3182055Baf  0.787
2010 Zordoky BN, El-Kadi AO. Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases. Pharmacology & Therapeutics. 125: 446-63. PMID 20093140 DOI: 10.1016/j.pharmthera.2009.12.002  0.619
2010 Anwar-mohamed A, Zordoky BN, Aboutabl ME, El-Kadi AO. Alteration of cardiac cytochrome P450-mediated arachidonic acid metabolism in response to lipopolysaccharide-induced acute systemic inflammation. Pharmacological Research. 61: 410-8. PMID 20045729 DOI: 10.1016/J.Phrs.2009.12.015  0.807
2010 Zordoky BN, El-Kadi AO. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and beta-naphthoflavone induce cellular hypertrophy in H9c2 cells by an aryl hydrocarbon receptor-dependant mechanism. Toxicology in Vitro : An International Journal Published in Association With Bibra. 24: 863-71. PMID 19969063 DOI: 10.1016/j.tiv.2009.12.002  0.581
2010 Zordoky BN, Anwar-Mohamed A, Aboutabl ME, El-Kadi AO. Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats. Toxicology and Applied Pharmacology. 242: 38-46. PMID 19796650 DOI: 10.1016/J.Taap.2009.09.012  0.805
2010 Zordoky B, El-Kadi A. Acute Doxorubicin Toxicity Differentially Alters Cytochrome P450 Expression in the Kidney and Liver of Male Sprague Dawley Rats Free Radical Biology and Medicine. 49: S75. DOI: 10.1016/J.Freeradbiomed.2010.10.187  0.656
2009 Aboutabl ME, Zordoky BN, El-Kadi AO. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. British Journal of Pharmacology. 158: 1808-19. PMID 19889059 DOI: 10.1111/J.1476-5381.2009.00461.X  0.79
2009 Zordoky BN, El-Kadi AO. Role of NF-kappaB in the regulation of cytochrome P450 enzymes. Current Drug Metabolism. 10: 164-78. PMID 19275551 DOI: 10.2174/138920009787522151  0.546
2008 Zordoky BN, Aboutabl ME, El-Kadi AO. Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2277-86. PMID 18725507 DOI: 10.1124/Dmd.108.023077  0.816
2008 Zordoky BN, El-Kadi AO. Induction of several cytochrome P450 genes by doxorubicin in H9c2 cells. Vascular Pharmacology. 49: 166-72. PMID 18707023 DOI: 10.1016/j.vph.2008.07.004  0.611
2008 Zordoky BN, El-Kadi AO. Modulation of cardiac and hepatic cytochrome P450 enzymes during heart failure. Current Drug Metabolism. 9: 122-8. PMID 18288954  0.645
2007 Zordoky BN, El-Kadi AO. H9c2 cell line is a valuable in vitro model to study the drug metabolizing enzymes in the heart. Journal of Pharmacological and Toxicological Methods. 56: 317-22. PMID 17662623 DOI: 10.1016/j.vascn.2007.06.001  0.568
Low-probability matches (unlikely to be authored by this person)
2021 Maayah ZH, Alam AS, Takahara S, Soni S, Ferdaoussi M, Matsumura N, Zordoky BN, Eisenstat DD, Dyck JRB. Resveratrol reduces cardiac NLRP3-inflammasome activation and systemic inflammation to lessen doxorubicin-induced cardiotoxicity in juvenile mice. Febs Letters. PMID 33876420 DOI: 10.1002/1873-3468.14091  0.298
2019 Grant M, Zordoky B. Abstract 266: Sex Differences in Anthracycline-Induced Cardiotoxicity in Young Mice Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.266  0.281
2022 Grant MKO, Razzoli M, Abdelgawad IY, Mansk R, Seelig D, Bartolomucci A, Zordoky BN. Juvenile exposure to doxorubicin alters the cardiovascular response to adult-onset psychosocial stress in mice. Stress (Amsterdam, Netherlands). 25: 291-304. PMID 35942624 DOI: 10.1080/10253890.2022.2104121  0.28
2023 Agostinucci K, Grant MKO, Melaku W, Nair C, Zordoky BN. Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in Male and Female Mice. Pharmaceuticals (Basel, Switzerland). 16. PMID 36986490 DOI: 10.3390/ph16030391  0.277
2018 Meiners B, Shenoy C, Zordoky BN. Clinical and preclinical evidence of sex-related differences in anthracycline-induced cardiotoxicity. Biology of Sex Differences. 9: 38. PMID 30157941 DOI: 10.1186/S13293-018-0198-2  0.271
2019 Abdelgawad IY, Grant MKO, Zordoky BN. Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology. Nutrients. 11. PMID 30875799 DOI: 10.3390/Nu11030627  0.265
2020 Abdelgawad IY, Grant MK, Lewis C, Popescu F, Largaespada D, Zordoky BN. Doxorubicin Cardiotoxicity in Young Tumor‐Bearing Mice The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06450  0.248
2014 Zordoky BN, Nagendran J, Pulinilkunnil T, Kienesberger PC, Masson G, Waller TJ, Kemp BE, Steinberg GR, Dyck JR. AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation. Circulation Research. 115: 518-24. PMID 25001074 DOI: 10.1161/CIRCRESAHA.115.304538  0.234
2018 Grant M, Razzoli M, Bartolomucci A, Zordoky B. Psychosocial stress unmasks latent doxorubicin-induced cardiotoxicity Journal of Molecular and Cellular Cardiology. 124: 93-94. DOI: 10.1016/J.Yjmcc.2018.07.038  0.229
2020 Carrera AN, Grant MKO, Zordoky BN. CYP1B1 as a therapeutic target in cardio-oncology. Clinical Science (London, England : 1979). 134: 2897-2927. PMID 33185690 DOI: 10.1042/CS20200310  0.226
2022 Abdelgawad IY, Agostinucci K, Ismail SG, Grant MKO, Zordoky BN. EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263. Cells. 11. PMID 35805077 DOI: 10.3390/cells11131992  0.202
2015 Zordoky BN, Robertson IM, Dyck JR. Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases. Biochimica Et Biophysica Acta. 1852: 1155-1177. PMID 25451966 DOI: 10.1016/j.bbadis.2014.10.016  0.199
2023 Abdelgawad IY, Agostinucci K, Sadaf B, Grant MKO, Zordoky BN. Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells. Frontiers in Aging. 4: 1170434. PMID 37168843 DOI: 10.3389/fragi.2023.1170434  0.186
2016 Zordoky BN, Radin MJ, Heller L, Tobias A, Matise I, Apple FS, McCune SA, Sharkey LC. The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity. Cardio-Oncology. 2. PMID 28758028 DOI: 10.1186/s40959-016-0013-3  0.178
2021 Abdelgawad IY, Grant MKO, Popescu FE, Largaespada DA, Zordoky BN. Doxorubicin Paradoxically Ameliorates Tumor-Induced Inflammation in Young Mice. International Journal of Molecular Sciences. 22. PMID 34445729 DOI: 10.3390/ijms22169023  0.177
2023 Dabour MS, Abdelgawad IY, Grant MKO, El-Sawaf ES, Zordoky BN. Canagliflozin mitigates carfilzomib-induced endothelial apoptosis via an AMPK-dependent pathway. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 164: 114907. PMID 37247463 DOI: 10.1016/j.biopha.2023.114907  0.171
2020 Abdelgawad IY, Sadak KT, Lone DW, Dabour MS, Niedernhofer LJ, Zordoky BN. Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence. Pharmacology & Therapeutics. 107751. PMID 33275998 DOI: 10.1016/j.pharmthera.2020.107751  0.129
2021 Walters K, Stornetta A, Jacobs F, Villalta PW, Razzoli M, Grant M, Zordoky B, Bartolomucci A, Borgatti A, Balbo S. Identification of new candidate biomarkers to support doxorubicin treatments in canine cancer patients. Bmc Veterinary Research. 17: 378. PMID 34876121 DOI: 10.1186/s12917-021-03062-x  0.09
2022 Abdelgawad IY, Agostinucci K, Zordoky BN. Cardiovascular ramifications of therapy-induced endothelial cell senescence in cancer survivors. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 1868: 166352. PMID 35041996 DOI: 10.1016/j.bbadis.2022.166352  0.079
2023 Blaes AH, Nair C, Everson-Rose S, Jewett P, Wolf J, Zordoky B. Psychological measures of stress and biomarkers of inflammation, aging, and endothelial dysfunction in breast cancer survivors on aromatase inhibitors. Scientific Reports. 13: 1677. PMID 36717689 DOI: 10.1038/s41598-023-28895-4  0.079
2014 Zordoky BN, Bark D, Soltys CL, Sung MM, Dyck JR. The anti-proliferative effect of metformin in triple-negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: implications for cancer therapy and prevention. Biochimica Et Biophysica Acta. 1840: 1943-57. PMID 24462945 DOI: 10.1016/j.bbagen.2014.01.023  0.074
2021 Blaes A, Konety S, Zordoky B. Response to Schoormans. Journal of the National Cancer Institute. 113: 214-215. PMID 33057689 DOI: 10.1093/jnci/djaa158  0.026
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