| Year |
Citation |
Score |
| 2019 |
Freedman LP. Multimeric Coactivator Complexes for Steroid/Nuclear Receptors. Trends in Endocrinology and Metabolism: Tem. 10: 403-407. PMID 10542397 DOI: 10.1016/S1043-2760(99)00208-8 |
0.493 |
|
| 2011 |
Shen Q, Bai Y, Chang KC, Wang Y, Burris TP, Freedman LP, Thompson CC, Nagpal S. Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes. The Journal of Biological Chemistry. 286: 14554-63. PMID 21349840 DOI: 10.1074/Jbc.M110.165704 |
0.302 |
|
| 2010 |
Berrodin TJ, Shen Q, Quinet EM, Yudt MR, Freedman LP, Nagpal S. Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. Molecular Pharmacology. 78: 1046-58. PMID 20837678 DOI: 10.1124/mol.110.065193 |
0.347 |
|
| 2010 |
Schmidt A, Kimmel DB, Bai C, Scafonas A, Rutledge S, Vogel RL, McElwee-Witmer S, Chen F, Nantermet PV, Kasparcova V, Leu CT, Zhang HZ, Duggan ME, Gentile MA, Hodor P, ... ... Freedman LP, et al. Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology. The Journal of Biological Chemistry. 285: 17054-64. PMID 20356837 DOI: 10.1074/jbc.M109.099002 |
0.368 |
|
| 2008 |
Cheskis BJ, Greger J, Cooch N, McNally C, Mclarney S, Lam HS, Rutledge S, Mekonnen B, Hauze D, Nagpal S, Freedman LP. MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways. Steroids. 73: 901-5. PMID 18261753 DOI: 10.1016/j.steroids.2007.12.028 |
0.312 |
|
| 2007 |
Cheskis BJ, Greger JG, Nagpal S, Freedman LP. Signaling by estrogens. Journal of Cellular Physiology. 213: 610-7. PMID 17886255 DOI: 10.1002/jcp.21253 |
0.313 |
|
| 2007 |
Greger JG, Fursov N, Cooch N, McLarney S, Freedman LP, Edwards DP, Cheskis BJ. Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 27: 1904-13. PMID 17194752 DOI: 10.1128/Mcb.01732-06 |
0.318 |
|
| 2006 |
Lipfert L, Fisher JE, Wei N, Scafonas A, Su Q, Yudkovitz J, Chen F, Warrier S, Birzin ET, Kim S, Chen HY, Tan Q, Schmidt A, Dininno F, Rohrer SP, ... ... Freedman LP, et al. Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation. Molecular Endocrinology (Baltimore, Md.). 20: 516-33. PMID 16223974 DOI: 10.1210/me.2005-0190 |
0.327 |
|
| 2005 |
Gamble MJ, Erdjument-Bromage H, Tempst P, Freedman LP, Fisher RP. The histone chaperone TAF-I/SET/INHAT is required for transcription in vitro of chromatin templates. Molecular and Cellular Biology. 25: 797-807. PMID 15632079 DOI: 10.1128/MCB.25.2.797-807.2005 |
0.343 |
|
| 2005 |
Nantermet PV, Masarachia P, Gentile MA, Pennypacker B, Xu J, Holder D, Gerhold D, Towler D, Schmidt A, Kimmel DB, Freedman LP, Harada S, Ray WJ. Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways. Endocrinology. 146: 564-78. PMID 15498879 DOI: 10.1210/En.2004-1132 |
0.304 |
|
| 2004 |
Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation. The Journal of Steroid Biochemistry and Molecular Biology. 89: 273-6. PMID 15225784 DOI: 10.1016/J.Jsbmb.2004.03.106 |
0.522 |
|
| 2004 |
Pineda Torra I, Freedman LP, Garabedian MJ. Identification of DRIP205 as a coactivator for the Farnesoid X receptor. The Journal of Biological Chemistry. 279: 36184-91. PMID 15187081 DOI: 10.1074/Jbc.M405126200 |
0.444 |
|
| 2003 |
Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation. Molecular Endocrinology (Baltimore, Md.). 17: 2329-39. PMID 12893881 DOI: 10.1210/Me.2003-0063 |
0.522 |
|
| 2003 |
Lau JF, Nusinzon I, Burakov D, Freedman LP, Horvath CM. Role of metazoan mediator proteins in interferon-responsive transcription. Molecular and Cellular Biology. 23: 620-8. PMID 12509459 DOI: 10.1128/Mcb.23.2.620-628.2003 |
0.787 |
|
| 2002 |
Maeda Y, Rachez C, Hawel L, Byus CV, Freedman LP, Sladek FM. Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205. Molecular Endocrinology (Baltimore, Md.). 16: 1502-10. PMID 12089346 DOI: 10.1210/Mend.16.7.0883 |
0.502 |
|
| 2002 |
Burakov D, Crofts LA, Chang CP, Freedman LP. Reciprocal recruitment of DRIP/mediator and p160 coactivator complexes in vivo by estrogen receptor. The Journal of Biological Chemistry. 277: 14359-62. PMID 11893728 DOI: 10.1074/Jbc.C200099200 |
0.791 |
|
| 2002 |
Barletta F, Freedman LP, Christakos S. Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex. Molecular Endocrinology (Baltimore, Md.). 16: 301-14. PMID 11818502 DOI: 10.1210/mend.16.2.0764 |
0.418 |
|
| 2002 |
Staeva-Vieira TP, Freedman LP. 1,25-dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 168: 1181-9. PMID 11801653 DOI: 10.4049/Jimmunol.168.3.1181 |
0.689 |
|
| 2001 |
Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD, Freedman LP. The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor. Blood. 98: 3290-300. PMID 11719366 DOI: 10.1182/Blood.V98.12.3290 |
0.452 |
|
| 2001 |
Rachez C, Freedman LP. Mediator complexes and transcription. Current Opinion in Cell Biology. 13: 274-80. PMID 11343897 DOI: 10.1016/S0955-0674(00)00209-X |
0.362 |
|
| 2001 |
Yang W, Shen J, Wu M, Arsura M, FitzGerald M, Suldan Z, Kim DW, Hofmann CS, Pianetti S, Romieu-Mourez R, Freedman LP, Sonenshein GE. Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc. Oncogene. 20: 1688-702. PMID 11313917 DOI: 10.1038/Sj.Onc.1204245 |
0.378 |
|
| 2000 |
Bromleigh VC, Freedman LP. p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells. Genes & Development. 14: 2581-6. PMID 11040212 |
0.724 |
|
| 2000 |
Yang W, Rachez C, Freedman LP. Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators. Molecular and Cellular Biology. 20: 8008-17. PMID 11027271 DOI: 10.1128/MCB.20.21.8008-8017.2000 |
0.462 |
|
| 2000 |
Burakov D, Wong CW, Rachez C, Cheskis BJ, Freedman LP. Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. The Journal of Biological Chemistry. 275: 20928-34. PMID 10770935 DOI: 10.1074/Jbc.M002013200 |
0.798 |
|
| 2000 |
Rachez C, Freedman LP. Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions. Gene. 246: 9-21. PMID 10767523 DOI: 10.1016/S0378-1119(00)00052-4 |
0.526 |
|
| 2000 |
Chiba N, Suldan Z, Freedman LP, Parvin JD. Binding of liganded vitamin D receptor to the vitamin D receptor interacting protein coactivator complex induces interaction with RNA polymerase II holoenzyme. The Journal of Biological Chemistry. 275: 10719-22. PMID 10753860 DOI: 10.1074/JBC.275.15.10719 |
0.416 |
|
| 2000 |
Rachez C, Gamble M, Chang CPB, Atkins GB, Lazar MA, Freedman LP. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes Molecular and Cellular Biology. 20: 2718-2726. PMID 10733574 DOI: 10.1128/Mcb.20.8.2718-2726.2000 |
0.518 |
|
| 2000 |
Freedman LP. Strategies for transcriptional activation by steroid/nuclear receptors. Journal of Cellular Biochemistry. 103-9. PMID 10629109 DOI: 10.1002/(SICI)1097-4644(1999)75:32+<103::AID-JCB13>3.0.CO;2-W |
0.508 |
|
| 2000 |
Shao W, Rosenauer A, Mann K, Chang CB, Rachez C, Freedman LP, Miller WH. Ligand-inducible interaction of the DRIP/TRAP coactivator complex with retinoid receptors in retinoic acid–sensitive and –resistant acute promyelocytic leukemia cells Blood. 96: 2233-2239. DOI: 10.1182/blood.v96.6.2233.h8002233_2233_2239 |
0.436 |
|
| 2000 |
Shao W, Rosenauer A, Mann K, Chang CB, Rachez C, Freedman LP, Miller WH. Ligand-inducible interaction of the DRIP/TRAP coactivator complex with retinoid receptors in retinoic acid–sensitive and –resistant acute promyelocytic leukemia cells Blood. 96: 2233-2239. DOI: 10.1182/Blood.V96.6.2233 |
0.436 |
|
| 1999 |
Lemon BD, Freedman LP. Nuclear receptor cofactors as chromatin remodelers. Current Opinion in Genetics & Development. 9: 499-504. PMID 10508693 DOI: 10.1016/S0959-437X(99)00010-6 |
0.484 |
|
| 1999 |
Hittelman AB, Burakov D, Iñiguez-Lluhí JA, Freedman LP, Garabedian MJ. Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. The Embo Journal. 18: 5380-8. PMID 10508170 DOI: 10.1093/Emboj/18.19.5380 |
0.799 |
|
| 1999 |
Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA. Coactivators for the orphan nuclear receptor RORalpha. Molecular Endocrinology (Baltimore, Md.). 13: 1550-7. PMID 10478845 DOI: 10.1210/Mend.13.9.0343 |
0.458 |
|
| 1999 |
Yang W, Freedman LP. 20-Epi analogues of 1,25-dihydroxyvitamin D3 are highly potent inducers of DRIP coactivator complex binding to the vitamin D3 receptor. The Journal of Biological Chemistry. 274: 16838-45. PMID 10358028 DOI: 10.1074/JBC.274.24.16838 |
0.479 |
|
| 1999 |
Towers TL, Staeva TP, Freedman LP. A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun. Molecular and Cellular Biology. 19: 4191-9. PMID 10330159 DOI: 10.1128/MCB.19.6.4191 |
0.436 |
|
| 1999 |
Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature. 398: 824-8. PMID 10235266 DOI: 10.1038/19783 |
0.748 |
|
| 1999 |
Freedman LP. Increasing the complexity of coactivation in nuclear receptor signaling. Cell. 97: 5-8. PMID 10199396 DOI: 10.1016/S0092-8674(00)80708-4 |
0.315 |
|
| 1999 |
Freedman LP. Transcriptional targets of the vitamin D3 receptor-mediating cell cycle arrest and differentiation. The Journal of Nutrition. 129: 581S-586S. PMID 10064337 DOI: 10.1093/jn/129.2.581S |
0.418 |
|
| 1999 |
Rots NY, Iavarone A, Bromleigh V, Freedman LP. Induced Differentiation of U937 Cells by 1,25-dihydroxyvitamin D3 Involves Cell Cycle Arrest in G1 That Is Preceded by a Transient Proliferative Burst and an Increase in Cyclin Expression Blood. 93: 2721-2729. DOI: 10.1182/Blood.V93.8.2721.408K28_2721_2729 |
0.711 |
|
| 1998 |
Raval-Pandya M, Freedman LP, Li H, Christakos S. Thyroid hormone receptor does not heterodimerize with the vitamin D receptor but represses vitamin D receptor-mediated transactivation. Molecular Endocrinology (Baltimore, Md.). 12: 1367-79. PMID 9731705 DOI: 10.1210/mend.12.9.0165 |
0.423 |
|
| 1998 |
Rachez C, Suldan Z, Ward J, Chang CP, Burakov D, Erdjument-Bromage H, Tempst P, Freedman LP. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes & Development. 12: 1787-800. PMID 9637681 DOI: 10.1101/Gad.12.12.1787 |
0.811 |
|
| 1998 |
Towers TL, Freedman LP. Granulocyte-macrophage colony-stimulating factor gene transcription is directly repressed by the vitamin D3 receptor. Implications for allosteric influences on nuclear receptor structure and function by a DNA element. The Journal of Biological Chemistry. 273: 10338-48. PMID 9553089 DOI: 10.1074/JBC.273.17.10338 |
0.441 |
|
| 1998 |
Rots NY, Liu M, Anderson EC, Freedman LP. A differential screen for ligand-regulated genes: identification of HoxA10 as a target of vitamin D3 induction in myeloid leukemic cells. Molecular and Cellular Biology. 18: 1911-8. PMID 9528762 DOI: 10.1128/MCB.18.4.1911 |
0.43 |
|
| 1997 |
Lemon BD, Fondell JD, Freedman LP. Retinoid X receptor:vitamin D3 receptor heterodimers promote stable preinitiation complex formation and direct 1,25-dihydroxyvitamin D3-dependent cell-free transcription. Molecular and Cellular Biology. 17: 1923-37. PMID 9121440 DOI: 10.1128/MCB.17.4.1923 |
0.504 |
|
| 1997 |
Liu M, Iavarone A, Freedman LP. Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation. The Journal of Biological Chemistry. 271: 31723-8. PMID 8940196 DOI: 10.1074/jbc.271.49.31723 |
0.433 |
|
| 1996 |
Yamauchi M, Ogata Y, Kim RH, Li JJ, Freedman LP, Sodek J. AP-1 regulation of the rat bone sialoprotein gene transcription is mediated through a TPA response element within a glucocorticoid response unit in the gene promoter. Matrix Biology : Journal of the International Society For Matrix Biology. 15: 119-30. PMID 8837013 DOI: 10.1016/S0945-053X(96)90153-5 |
0.335 |
|
| 1996 |
Kim RH, Li JJ, Ogata Y, Yamauchi M, Freedman LP, Sodek J. Identification of a vitamin D3-response element that overlaps a unique inverted TATA box in the rat bone sialoprotein gene. The Biochemical Journal. 318: 219-26. PMID 8761475 DOI: 10.1042/Bj3180219 |
0.357 |
|
| 1996 |
Lemon BD, Freedman LP. Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo. Molecular and Cellular Biology. 16: 1006-16. PMID 8622645 DOI: 10.1128/MCB.16.3.1006 |
0.485 |
|
| 1996 |
Cheskis B, Lemon BD, Uskokovic M, Lomedico PT, Freedman LP. Vitamin D3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogs of 1,25-dihydroxyvitamin D3. Molecular Endocrinology (Baltimore, Md.). 9: 1814-24. PMID 8614417 DOI: 10.1210/mend.9.12.8614417 |
0.358 |
|
| 1996 |
Cheskis B, Freedman LP. Modulation of nuclear receptor interactions by ligands: kinetic analysis using surface plasmon resonance. Biochemistry. 35: 3309-18. PMID 8605168 DOI: 10.1021/bi952283r |
0.394 |
|
| 1996 |
Liu M, Lee MH, Cohen M, Bommakanti M, Freedman LP. Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes & Development. 10: 142-53. PMID 8566748 DOI: 10.1101/Gad.10.2.142 |
0.49 |
|
| 1995 |
Luisi BF, Schwabe JW, Freedman LP. The steroid/nuclear receptors: from three-dimensional structure to complex function. Vitamins and Hormones. 49: 1-47. PMID 7810069 DOI: 10.1016/S0083-6729(08)61145-0 |
0.308 |
|
| 1995 |
Luisi B, Freedman L. Nuclear receptors. Dymer, dymer binding tight. Nature. 375: 359-60. PMID 7760925 DOI: 10.1038/375359A0 |
0.427 |
|
| 1995 |
Liu M, Freedman LP. Transcriptional synergism between the vitamin D3 receptor and other nonreceptor transcription factors. Molecular Endocrinology (Baltimore, Md.). 8: 1593-604. PMID 7708050 DOI: 10.1210/mend.8.12.7708050 |
0.441 |
|
| 1995 |
Ogata Y, Yamauchi M, Kim RH, Li JJ, Freedman LP, Sodek J. Glucocorticoid regulation of bone sialoprotein (BSP) gene expression. Identification of a glucocorticoid response element in the bone sialoprotein gene promoter. European Journal of Biochemistry / Febs. 230: 183-92. PMID 7601099 DOI: 10.1111/j.1432-1033.1995.0183i.x |
0.343 |
|
| 1995 |
Alroy I, Towers TL, Freedman LP. Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Molecular and Cellular Biology. 15: 5789-99. PMID 7565732 DOI: 10.1128/MCB.15.10.5789 |
0.447 |
|
| 1995 |
Sodek J, Kim RH, Ogata Y, Li J, Yamauchi M, Zhang Q, Freedman LP. Regulation of bone sialoprotein gene transcription by steroid hormones. Connective Tissue Research. 32: 209-17. PMID 7554919 DOI: 10.3109/03008209509013725 |
0.319 |
|
| 1994 |
Cheskis B, Freedman LP. Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers. Molecular and Cellular Biology. 14: 3329-38. PMID 8164684 DOI: 10.1128/MCB.14.5.3329 |
0.406 |
|
| 1994 |
Freedman LP, Arce V, Perez Fernandez R. DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor. Molecular Endocrinology (Baltimore, Md.). 8: 265-73. PMID 8015545 DOI: 10.1210/mend.8.3.8015545 |
0.326 |
|
| 1993 |
Freedman LP, Luisi BF. On the mechanism of DNA binding by nuclear hormone receptors: a structural and functional perspective. Journal of Cellular Biochemistry. 51: 140-50. PMID 8440748 DOI: 10.1002/jcb.240510205 |
0.336 |
|
| 1993 |
Towers TL, Luisi BF, Asianov A, Freedman LP. DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element. Proceedings of the National Academy of Sciences of the United States of America. 90: 6310-4. PMID 8392196 DOI: 10.1073/pnas.90.13.6310 |
0.357 |
|
| 1993 |
Perez-Fernandez R, Arce V, Freedman LP. Delineation of a DNA recognition element for the vitamin D3 receptor by binding site selection. Biochemical and Biophysical Research Communications. 192: 728-37. PMID 8387288 DOI: 10.1006/bbrc.1993.1475 |
0.342 |
|
| 1992 |
Freedman LP, Towers TL. DNA binding properties of the vitamin D3 receptor zinc finger region. Molecular Endocrinology (Baltimore, Md.). 5: 1815-26. PMID 1665202 DOI: 10.1210/mend-5-12-1815 |
0.369 |
|
| 1989 |
Schena M, Freedman LP, Yamamoto KR. Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities. Genes & Development. 3: 1590-601. PMID 2515114 DOI: 10.1101/Gad.3.10.1590 |
0.356 |
|
| 1989 |
Freedman LP, Yoshinaga SK, Vanderbilt JN, Yamamoto KR. In vitro transcription enhancement by purified derivatives of the glucocorticoid receptor. Science (New York, N.Y.). 245: 298-301. PMID 2473529 DOI: 10.1126/Science.2473529 |
0.416 |
|
| 1988 |
Freedman LP, Luisi BF, Korszun ZR, Basavappa R, Sigler PB, Yamamoto KR. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Nature. 334: 543-6. PMID 3043231 DOI: 10.1038/334543A0 |
0.309 |
|
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