Bruce R. Pitt - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Pathology, Physiology Biology, Cell Biology

131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt B, Thomson AW, Fan MH, Billiar TR, et al. IL-33-mediated IL-13 secretion by ST2+ Treg controls inflammation after lung injury. Jci Insight. PMID 30779711 DOI: 10.1172/Jci.Insight.123919  0.301
2019 Xia YF, Chang J, Yang JF, Ouyang W, Pitt B, Billiar T, Zhang LM. Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression. International Journal of Molecular Medicine. PMID 30664165 DOI: 10.3892/Ijmm.2019.4067  0.378
2018 Ding X, Tong Y, Jin S, Chen Z, Li T, Billiar TR, Pitt BR, Li Q, Zhang LM. Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1-αvβ5 integrin pathway in TLR4-mediated inflammation and injury. Critical Care (London, England). 22: 302. PMID 30445996 DOI: 10.1186/S13054-018-2237-0  0.378
2018 Ding X, Jin S, Shao Z, Xu L, Yu Z, Tong Y, Chen Z, Turnquist H, Pitt BR, Billiar TR, Zhang LM, Li Q. The IL-33-ST2 Pathway Contributes to Ventilator-Induced Lung Injury in Septic Mice in a Tidal Volume-Dependent Manner. Shock (Augusta, Ga.). PMID 30192340 DOI: 10.1097/Shk.0000000000001260  0.37
2016 Chen Z, Ding X, Jin S, Pitt B, Zhang L, Billiar T, Li Q. WISP1-αvβ3 integrin signaling positively regulates TLR-triggered inflammation response in sepsis induced lung injury. Scientific Reports. 6: 28841. PMID 27349568 DOI: 10.1038/Srep28841  0.38
2016 Buland JR, Wasserloos KJ, Tyurin VA, Tyurina YY, Amoscato AA, Mallampalli RK, Chen BB, Zhao J, Zhao Y, Ofori-Acquah S, Kagan VE, Pitt BR. Biosynthesis of Oxidized Lipid Mediators via Lipoprotein Associated Phospholipase A2 Hydrolysis of Extracellular Cardiolipin Induces Endothelial Toxicity. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00038.2016. PMID 27233995 DOI: 10.1152/Ajplung.00038.2016  0.389
2014 Tyurina YY, Poloyac SM, Tyurin VA, Kapralov AA, Jiang J, Anthonymuthu TS, Kapralova VI, Vikulina AS, Jung MY, Epperly MW, Mohammadyani D, Klein-Seetharaman J, Jackson TC, Kochanek PM, Pitt BR, et al. A mitochondrial pathway for biosynthesis of lipid mediators. Nature Chemistry. 6: 542-52. PMID 24848241 DOI: 10.1038/Nchem.1924  0.307
2014 Zimmerman MW, McQueeney KE, Isenberg JS, Pitt BR, Wasserloos KA, Homanics GE, Lazo JS. Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. The Journal of Biological Chemistry. 289: 5904-13. PMID 24403062 DOI: 10.1074/Jbc.M113.480038  0.344
2013 Li HH, Li J, Wasserloos KJ, Wallace C, Sullivan MG, Bauer PM, Stolz DB, Lee JS, Watkins SC, St Croix CM, Pitt BR, Zhang LM. Caveolae-dependent and -independent uptake of albumin in cultured rodent pulmonary endothelial cells. Plos One. 8: e81903. PMID 24312378 DOI: 10.1371/Journal.Pone.0081903  0.432
2013 Lee SM, McLaughlin JN, Frederick DR, Zhu L, Thambiayya K, Wasserloos KJ, Kaminski I, Pearce LL, Peterson J, Li J, Latoche JD, Peck Palmer OM, Stolz DB, Fattman CL, Alcorn JF, ... ... Pitt BR, et al. Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L350-60. PMID 23275622 DOI: 10.1152/Ajplung.00243.2012  0.742
2012 Thambiayya K, Kaynar AM, St Croix CM, Pitt BR. Functional role of intracellular labile zinc in pulmonary endothelium. Pulmonary Circulation. 2: 443-51. PMID 23372928 DOI: 10.4103/2045-8932.105032  0.754
2012 Darwiche SS, Pfeifer R, Menzel C, Ruan X, Hoffman M, Cai C, Chanthaphavong RS, Loughran P, Pitt BR, Hoffman R, Pape HC, Billiar TR. Inducible nitric oxide synthase contributes to immune dysfunction following trauma. Shock (Augusta, Ga.). 38: 499-507. PMID 23042189 DOI: 10.1097/Shk.0B013E31826C5Afe  0.315
2012 Li HH, Li Q, Liu P, Liu Y, Li J, Wasserloos K, Chao W, You M, Oury TD, Chhinder S, Hackam DJ, Billiar TR, Leikauf GD, Pitt BR, Zhang LM. WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. American Journal of Respiratory Cell and Molecular Biology. 47: 528-35. PMID 22700866 DOI: 10.1165/Rcmb.2012-0127Oc  0.421
2012 Thambiayya K, Wasserloos K, Kagan VE, Stoyanovsky D, Pitt BR. A critical role for increased labile zinc in reducing sensitivity of cultured sheep pulmonary artery endothelial cells to LPS-induced apoptosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 302: L1287-95. PMID 22523284 DOI: 10.1152/Ajplung.00385.2011  0.769
2012 Gorbunov NV, Atkins JL, Gurusamy N, Pitt BR. Iron-induced remodeling in cultured rat pulmonary artery endothelial cells. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 25: 203-17. PMID 22089858 DOI: 10.1007/S10534-011-9498-2  0.367
2011 Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, ... ... Pitt BR, et al. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nature Communications. 2: 497. PMID 21988913 DOI: 10.1038/Ncomms1499  0.33
2011 Bernal PJ, Bauer EM, Cao R, Maniar S, Mosher M, Chen J, Wang QJ, Glorioso JC, Pitt BR, Watkins SC, St Croix CM. A role for zinc in regulating hypoxia-induced contractile events in pulmonary endothelium. American Journal of Physiology. Lung Cellular and Molecular Physiology. 300: L874-86. PMID 21378023 DOI: 10.1152/Ajplung.00328.2010  0.773
2011 Tyurina YY, Tyurin VA, Kapralova VI, Wasserloos K, Mosher M, Epperly MW, Greenberger JS, Pitt BR, Kagan VE. Oxidative lipidomics of γ-radiation-induced lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Radiation Research. 175: 610-21. PMID 21338246 DOI: 10.1667/Rr2297.1  0.42
2011 Thambiayya K, Wasserloos KJ, Huang Z, Kagan VE, St Croix CM, Pitt BR. LPS-induced decrease in intracellular labile zinc, [Zn]i, contributes to apoptosis in cultured sheep pulmonary artery endothelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 300: L624-32. PMID 21239534 DOI: 10.1152/Ajplung.00376.2010  0.767
2011 Li HH, Xu J, Wasserloos KJ, Li J, Tyurina YY, Kagan VE, Wang X, Chen AF, Liu ZQ, Stoyanovsky D, Pitt BR, Zhang LM. Cytoprotective effects of albumin, nitrosated or reduced, in cultured rat pulmonary vascular cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 300: L526-33. PMID 21239532 DOI: 10.1152/Ajplung.00282.2010  0.461
2010 John E, Laskow TC, Buchser WJ, Pitt BR, Basse PH, Butterfield LH, Kalinski P, Lotze MT. Zinc in innate and adaptive tumor immunity. Journal of Translational Medicine. 8: 118. PMID 21087493 DOI: 10.1186/1479-5876-8-118  0.371
2010 Li H, Cao R, Wasserloos KJ, Bernal P, Liu ZQ, Pitt BR, St Croix CM. Nitric oxide and zinc homeostasis in pulmonary endothelium. Annals of the New York Academy of Sciences. 1203: 73-8. PMID 20716286 DOI: 10.1111/J.1749-6632.2010.05558.X  0.475
2010 Li H, Su X, Yan X, Wasserloos K, Chao W, Kaynar AM, Liu ZQ, Leikauf GD, Pitt BR, Zhang LM. Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice. Anesthesiology. 113: 619-29. PMID 20683250 DOI: 10.1097/Aln.0B013E3181E89Ab2  0.383
2010 Szczepaniak WS, Pitt BR, McVerry BJ. S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. American Journal of Physiology. Lung Cellular and Molecular Physiology. 299: L137-45. PMID 20435688 DOI: 10.1152/Ajplung.00233.2009  0.366
2010 Tyurina YY, Tyurin VA, Kaynar AM, Kapralova VI, Wasserloos K, Li J, Mosher M, Wright L, Wipf P, Watkins S, Pitt BR, Kagan VE. Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 299: L73-85. PMID 20418384 DOI: 10.1152/Ajplung.00035.2010  0.442
2010 Polk AA, Maul TM, McKeel DT, Snyder TA, Lehocky CA, Pitt B, Stolz DB, Federspiel WJ, Wagner WR. A biohybrid artificial lung prototype with active mixing of endothelialized microporous hollow fibers. Biotechnology and Bioengineering. 106: 490-500. PMID 20091735 DOI: 10.1002/Bit.22675  0.364
2009 Li J, Wilson A, Gao X, Kuruba R, Liu Y, Poloyac S, Pitt B, Xie W, Li S. Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine. The Journal of Pharmacology and Experimental Therapeutics. 331: 234-43. PMID 19605523 DOI: 10.1124/Jpet.109.153510  0.311
2009 Tyurin VA, Tyurina YY, Jung MY, Tungekar MA, Wasserloos KJ, Bayir H, Greenberger JS, Kochanek PM, Shvedova AA, Pitt B, Kagan VE. Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 877: 2863-72. PMID 19328050 DOI: 10.1016/J.Jchromb.2009.03.007  0.392
2009 Kagan VE, Bayir HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA, Borisenko G. Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radical Biology & Medicine. 46: 1439-53. PMID 19285551 DOI: 10.1016/J.Freeradbiomed.2009.03.004  0.308
2009 Nemec AA, Leikauf GD, Pitt BR, Wasserloos KJ, Barchowsky A. Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 41: 69-75. PMID 19097988 DOI: 10.1165/Rcmb.2008-0409Oc  0.747
2008 Bernal PJ, Leelavanichkul K, Bauer E, Cao R, Wilson A, Wasserloos KJ, Watkins SC, Pitt BR, St Croix CM. Nitric-oxide-mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone. Circulation Research. 102: 1575-83. PMID 18483408 DOI: 10.1161/Circresaha.108.171264  0.792
2008 Kaynar AM, Houghton AM, Lum EH, Pitt BR, Shapiro SD. Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. American Journal of Respiratory Cell and Molecular Biology. 39: 53-60. PMID 18276796 DOI: 10.1165/Rcmb.2007-0315Oc  0.405
2008 Fattman CL, Gambelli F, Hoyle G, Pitt BR, Ortiz LA. Epithelial expression of TIMP-1 does not alter sensitivity to bleomycin-induced lung injury in C57BL/6 mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L572-81. PMID 18178676 DOI: 10.1152/Ajplung.00291.2007  0.378
2008 Kleinschmidt AM, Nassiri M, Stitt MS, Wasserloos K, Watkins SC, Pitt BR, Jahroudi N. Sequences in intron 51 of the von Willebrand factor gene target promoter activation to a subset of lung endothelial cells in transgenic mice. The Journal of Biological Chemistry. 283: 2741-50. PMID 18048367 DOI: 10.1074/Jbc.M705466200  0.36
2008 Li J, Wilson A, Kuruba R, Zhang Q, Gao X, He F, Zhang LM, Pitt BR, Xie W, Li S. FXR-mediated regulation of eNOS expression in vascular endothelial cells. Cardiovascular Research. 77: 169-77. PMID 18006476 DOI: 10.1093/Cvr/Cvm016  0.351
2008 Zhang Q, He F, Kuruba R, Gao X, Wilson A, Li J, Billiar TR, Pitt BR, Xie W, Li S. FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. Cardiovascular Research. 77: 560-9. PMID 18006431 DOI: 10.1093/Cvr/Cvm068  0.322
2008 Kagan V, Tyurina Y, Wasserlos K, Stewart R, Stitt M, Kaynar M, Pitt B. OXIDATIVE LIPIDOMICS OF HYPEROXIC LUNG INJURY Atherosclerosis Supplements. 9: 58. DOI: 10.1016/S1567-5688(08)70229-0  0.346
2007 Tyurina YY, Basova LV, Konduru NV, Tyurin VA, Potapovich AI, Cai P, Bayir H, Stoyanovsky D, Pitt BR, Shvedova AA, Fadeel B, Kagan VE. Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation. The Journal of Biological Chemistry. 282: 8498-509. PMID 17229723 DOI: 10.1074/Jbc.M606950200  0.41
2006 Zhang LM, St Croix C, Cao R, Wasserloos K, Watkins SC, Stevens T, Li S, Tyurin V, Kagan VE, Pitt BR. Cell-surface protein disulfide isomerase is required for transnitrosation of metallothionein by S-nitroso-albumin in intact rat pulmonary vascular endothelial cells. Experimental Biology and Medicine (Maywood, N.J.). 231: 1507-15. PMID 17018873 DOI: 10.1177/153537020623100909  0.42
2006 Stitt MS, Wasserloos KJ, Tang X, Liu X, Pitt BR, St Croix CM. Nitric oxide-induced nuclear translocation of the metal responsive transcription factor, MTF-1 is mediated by zinc release from metallothionein. Vascular Pharmacology. 44: 149-55. PMID 16423564 DOI: 10.1016/J.Vph.2005.10.004  0.454
2006 He F, Li J, Mu Y, Kuruba R, Ma Z, Wilson A, Alber S, Jiang Y, Stevens T, Watkins S, Pitt B, Xie W, Li S. Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells. Circulation Research. 98: 192-9. PMID 16357303 DOI: 10.1161/01.Res.0000200400.55539.85  0.352
2006 Jahroudi N, Nassiri M, Stitt MS, Wasserloos K, Watkins SC, Pitt BR, Kleinschmidt AM. Sequences in Intron 51 of the VWF Gene Target Promoter Activation to a Subset of Lung Endothelial Cells in Transgenic Mice. Blood. 108: 1798-1798. DOI: 10.1182/Blood.V108.11.1798.1798  0.347
2006 Matthay MA, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB. A new era of opportunities in lung research American Journal of Physiology - Lung Cellular and Molecular Physiology. 290. DOI: 10.1152/Ajplung.00381.2005  0.332
2005 St Croix CM, Stitt MS, Watkins SC, Pitt BR. Fluorescence resonance energy transfer-based assays for the real-time detection of nitric oxide signaling. Methods in Enzymology. 396: 317-26. PMID 16291241 DOI: 10.1016/S0076-6879(05)96026-6  0.352
2005 Stoyanovsky DA, Tyurina YY, Tyurin VA, Anand D, Mandavia DN, Gius D, Ivanova J, Pitt B, Billiar TR, Kagan VE. Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. Journal of the American Chemical Society. 127: 15815-23. PMID 16277524 DOI: 10.1021/Ja0529135  0.317
2005 St Croix CM, Leelavaninchkul K, Watkins SC, Kagan VE, Pitt BR. Nitric oxide and zinc homeostasis in acute lung injury. Proceedings of the American Thoracic Society. 2: 236-42. PMID 16222044 DOI: 10.1513/pats.200501-007AC  0.335
2005 Wilson A, He F, Li J, Ma Z, Pitt B, Li S. Targeted delivery of therapeutic oligonucleotides to pulmonary circulation. Advances in Genetics. 54: 21-41. PMID 16096006 DOI: 10.1016/S0065-2660(05)54002-1  0.34
2005 Wilson A, Zhou W, Champion HC, Alber S, Tang ZL, Kennel S, Watkins S, Huang L, Pitt B, Li S. Targeted delivery of oligodeoxynucleotides to mouse lung endothelial cells in vitro and in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 510-8. PMID 15953766 DOI: 10.1016/J.Ymthe.2005.04.005  0.414
2005 Ma Z, Li J, He F, Wilson A, Pitt B, Li S. Cationic lipids enhance siRNA-mediated interferon response in mice. Biochemical and Biophysical Research Communications. 330: 755-9. PMID 15809061 DOI: 10.1016/J.Bbrc.2005.03.041  0.301
2005 Gandley RE, Tyurin VA, Huang W, Arroyo A, Daftary A, Harger G, Jiang J, Pitt B, Taylor RN, Hubel CA, Kagan VE. S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma. Hypertension. 45: 21-7. PMID 15569857 DOI: 10.1161/01.Hyp.0000150158.42620.3E  0.307
2005 Wilson AS, Kennel SJ, Huang L, Pitt BR, Li S. 586. Novel Lipidic Vectors for Targeted Delivery of Functional Oligonucleotides to Pulmonary Endothelium Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.126  0.37
2004 Tyurina YY, Tyurin VA, Zhao Q, Djukic M, Quinn PJ, Pitt BR, Kagan VE. Oxidation of phosphatidylserine: a mechanism for plasma membrane phospholipid scrambling during apoptosis? Biochemical and Biophysical Research Communications. 324: 1059-64. PMID 15485662 DOI: 10.1016/J.Bbrc.2004.09.102  0.313
2004 St Croix CM, Stitt MS, Leelavanichkul K, Wasserloos KJ, Pitt BR, Watkins SC. Nitric oxide-induced modification of protein thiolate clusters as determined by spectral fluorescence resonance energy transfer in live endothelial cells. Free Radical Biology & Medicine. 37: 785-92. PMID 15304254 DOI: 10.1016/J.Freeradbiomed.2004.06.004  0.332
2004 Pitt BR, Ortiz LA. Stem cells in lung biology American Journal of Physiology - Lung Cellular and Molecular Physiology. 286. PMID 15003931 DOI: 10.1152/Ajplung.00392.2003  0.337
2004 Ma Z, Li J, Yang L, Mu Y, Xie W, Pitt B, Li S. Inhibition of LPS- and CpG DNA-induced TNF-alpha response by oxidized phospholipids. American Journal of Physiology. Lung Cellular and Molecular Physiology. 286: L808-16. PMID 14644758 DOI: 10.1152/Ajplung.00220.2003  0.308
2004 St Croix CM, Stitt MS, Wasserloos KJ, Pitt BR, Watkins SC. Spectral FRET to Measure Nitric Oxide (NO) Induced Modification of Protein Thiolate Clusters in Live Pulmonary Endothelial Cells Microscopy and Microanalysis. 10: 1236-1237. DOI: 10.1017/S1431927604880036  0.376
2002 Jiang J, St Croix CM, Sussman N, Zhao Q, Pitt BR, Kagan VE. Contribution of glutathione and metallothioneins to protection against copper toxicity and redox cycling: quantitative analysis using MT+/+ and MT-/- mouse lung fibroblast cells. Chemical Research in Toxicology. 15: 1080-7. PMID 12184792 DOI: 10.1021/Tx020022U  0.368
2002 Tang ZL, Wasserloos KJ, Liu X, Stitt MS, Reynolds IJ, Pitt BR, St Croix CM. Nitric oxide decreases the sensitivity of pulmonary endothelial cells to LPS-induced apoptosis in a zinc-dependent fashion. Molecular and Cellular Biochemistry. 234: 211-7. PMID 12162436 DOI: 10.1007/978-1-4615-1087-1_24  0.538
2002 Ma Z, Zhang J, Alber S, Dileo J, Negishi Y, Stolz D, Watkins S, Huang L, Pitt B, Li S. Lipid-mediated delivery of oligonucleotide to pulmonary endothelium. American Journal of Respiratory Cell and Molecular Biology. 27: 151-9. PMID 12151306 DOI: 10.1165/Ajrcmb.27.2.4653  0.422
2002 Fabisiak JP, Borisenko GG, Liu SX, Tyurin VA, Pitt BR, Kagan VE. Redox sensor function of metallothioneins. Methods in Enzymology. 353: 268-81. PMID 12078502 DOI: 10.1016/S0076-6879(02)53055-X  0.341
2002 Ma Z, Mi Z, Wilson A, Alber S, Robbins PD, Watkins S, Pitt B, Li S. Redirecting adenovirus to pulmonary endothelium by cationic liposomes Gene Therapy. 9: 176-182. PMID 11859420 DOI: 10.1038/Sj.Gt.3301636  0.366
2002 Pearce LL, Kanai AJ, Birder LA, Pitt BR, Peterson J. The catabolic fate of nitric oxide: the nitric oxide oxidase and peroxynitrite reductase activities of cytochrome oxidase. The Journal of Biological Chemistry. 277: 13556-62. PMID 11825895 DOI: 10.1074/Jbc.M109838200  0.307
2002 St Croix CM, Wasserloos KJ, Dineley KE, Reynolds IJ, Levitan ES, Pitt BR. Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L185-92. PMID 11792622 DOI: 10.1152/Ajplung.00267.2001  0.467
2002 Pitt BR, St Croix CM. Complex regulation of iNOS in lung. American Journal of Respiratory Cell and Molecular Biology. 26: 6-9. PMID 11751197 DOI: 10.1165/Ajrcmb.26.1.F224  0.44
2001 Finder JD, Petrus JL, Hamilton A, Villavicencio RT, Pitt BR, Sebti SM. Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 281: L816-23. PMID 11557585 DOI: 10.1152/Ajplung.2001.281.4.L816  0.329
2001 Tang ZL, Wasserloos K, St Croix CM, Pitt BR. Role of zinc in pulmonary endothelial cell response to oxidative stress. American Journal of Physiology. Lung Cellular and Molecular Physiology. 281: L243-9. PMID 11404267 DOI: 10.1152/Ajplung.2001.281.1.L243  0.488
2001 Pearce LL, Epperly MW, Greenberger JS, Pitt BR, Peterson J. Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide. Nitric Oxide : Biology and Chemistry. 5: 128-36. PMID 11292362 DOI: 10.1006/Niox.2001.0338  0.301
2001 Hauser GJ, Wasserloos K, Dayao EK, Pitt BR. Effect of sodium arsenite on iNOS expression and vascular hyporeactivity associated with cecal ligation and puncture in the rat. Shock (Augusta, Ga.). 15: 73-6. PMID 11198361 DOI: 10.1097/00024382-200115010-00012  0.343
2001 Liu SX, Kawai K, Tyurin VA, Tyurina YY, Borisenko GG, Fabisiak JP, Quinn PJ, Pitt BR, Kagan VE. Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate Biochemical Journal. 354: 397-406. PMID 11171119 DOI: 10.1042/0264-6021:3540397  0.378
2000 Kawai K, Liu SX, Tyurin VA, Tyurina YY, Borisenko GG, Jiang JF, St Croix CM, Fabisiak JP, Pitt BR, Kagan VE. Antioxidant and antiapoptotic function of metallothioneins in HL-60 cells challenged with copper nitrilotriacetate Chemical Research in Toxicology. 13: 1275-1286. PMID 11123969 DOI: 10.1021/tx000119l  0.307
2000 Merker MP, Pitt BR, Choi AM, Hassoun PM, Dawson CA, Fisher AB. Lung redox homeostasis: emerging concepts. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L413-7. PMID 10956613 DOI: 10.1152/Ajplung.2000.279.3.L413  0.423
2000 Erukhimov JA, Tang ZL, Johnson BA, Donahoe MP, Razzack JA, Gibson KF, Lee WM, Wasserloos KJ, Watkins SA, Pitt BR. Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cells. American Journal of Respiratory and Critical Care Medicine. 162: 288-94. PMID 10903256 DOI: 10.1164/Ajrccm.162.1.9806088  0.379
2000 Villavicencio RT, Liu S, Kibbe MR, Williams DL, Ganster RW, Dyer KF, Tweardy DJ, Billiar TR, Pitt BR. Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression. Shock (Augusta, Ga.). 13: 441-5. PMID 10847630 DOI: 10.1097/00024382-200006000-00004  0.323
2000 Pearce LL, Wasserloos K, St Croix CM, Gandley R, Levitan ES, Pitt BR. Metallothionein, nitric oxide and zinc homeostasis in vascular endothelial cells. The Journal of Nutrition. 130: 1467S-70S. PMID 10801961 DOI: 10.1093/Jn/130.5.1467S  0.444
2000 Schwarz MA, Zhang F, Lane JE, Schachtner S, Jin Y, Deutsch G, Starnes V, Pitt BR. Angiogenesis and morphogenesis of murine fetal distal lung in an allograft model American Journal of Physiology - Lung Cellular and Molecular Physiology. 278: L1000-L1007. PMID 10781431 DOI: 10.1152/Ajplung.2000.278.5.L1000  0.364
2000 Li S, Tan Y, Viroonchatapan E, Pitt BR, Huang L. Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody. American Journal of Physiology. Lung Cellular and Molecular Physiology. 278: L504-11. PMID 10710522 DOI: 10.1152/Ajplung.2000.278.3.L504  0.374
2000 Johnson BA, Pitt BR, Davies P. Pulmonary arterial smooth muscle cells modulate cytokine- and LPS-induced cytotoxicity in endothelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 278: L460-8. PMID 10710517 DOI: 10.1152/Ajplung.2000.278.3.L460  0.415
2000 Boota A, Johnson B, Lee KL, Blaskovich MA, Liu SX, Kagan VE, Hamilton A, Pitt B, Sebti SM, Davies P. Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle American Journal of Physiology - Lung Cellular and Molecular Physiology. 278. PMID 10666117 DOI: 10.1152/Ajplung.2000.278.2.L329  0.34
2000 Pearce LL, Gandley RE, Han W, Wasserloos K, Stitt M, Kanai AJ, McLaughlin MK, Pitt BR, Levitan ES. Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein. Proceedings of the National Academy of Sciences of the United States of America. 97: 477-82. PMID 10618443 DOI: 10.1073/Pnas.97.1.477  0.365
2000 Pearce LL, Pitt BR, Peterson J. The peroxynitrite reductase activity of cytochrome c oxidase involves a two-electron redox reaction at the heme a(3)-Cu(B) site. The Journal of Biological Chemistry. 274: 35763-7. PMID 10585458 DOI: 10.1074/Jbc.274.50.35763  0.301
1999 Fabisiak JP, Pearce LL, Borisenko GG, Tyurina YY, Tyurin VA, Razzack J, Lazo JS, Pitt BR, Kagan VE. Bifunctional Anti-/Prooxidant Potential of Metallothionein: Redox Signaling of Copper Binding and Release Antioxidants and Redox Signaling. 1: 349-364. PMID 11229446 DOI: 10.1089/Ars.1999.1.3-349  0.307
1999 Davidge ST, Pitt BR, McLaughlin MK, Roberts JM, Johnson BA. Biphasic stimulation of prostacyclin by endogenous nitric oxide (NO) in endothelial cells transfected with inducible NO synthase. General Pharmacology. 33: 383-7. PMID 10553879 DOI: 10.1016/S0306-3623(99)00033-6  0.414
1999 Tan Y, Li S, Pitt BR, Huang L. The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Human Gene Therapy. 10: 2153-61. PMID 10498247 DOI: 10.1089/10430349950017149  0.357
1999 Li S, Wu SP, Whitmore M, Loeffert EJ, Wang L, Watkins SC, Pitt BR, Huang L. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors. The American Journal of Physiology. 276: L796-804. PMID 10330036 DOI: 10.1152/Ajplung.1999.276.5.L796  0.385
1999 Fabisiak JP, Tyurin VA, Tyurina YY, Borisenko GG, Korotaeva A, Pitt BR, Lazo JS, Kagan VE. Redox regulation of copper-metallothionein Archives of Biochemistry and Biophysics. 363: 171-181. PMID 10049512 DOI: 10.1006/Abbi.1998.1077  0.312
1999 Villavicencio R, Schwarz N, Baust J, Liu S, Hierholzer C, Pitt B, Billiar T. TIME COURSE OF INDUCIBLE NITRIC OXIDE SYNTHASE AND CYCLOOXYGENASE-2 UPREGULATION DURING HEMORRHAGIC SHOCK Shock. 11: 77. DOI: 10.1097/00024382-199906001-00266  0.307
1998 Ceneviva GD, Tzeng E, Hoyt DG, Yee E, Gallagher A, Engelhardt JF, Kim YM, Billiar TR, Watkins SA, Pitt BR. Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 275: L717-L728. PMID 29585641 DOI: 10.1152/ajplung.1998.275.4.L717  0.33
1998 Ceneviva GD, Tzeng E, Hoyt DG, Yee E, Gallagher A, Engelhardt JF, Kim YM, Billiar TR, Watkins SA, Pitt BR. Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells. The American Journal of Physiology. 275: L717-28. PMID 9755104 DOI: 10.1152/Ajplung.1998.275.4.L717  0.437
1998 Stark WW, Blaskovich MA, Johnson BA, Qian Y, Vasudevan A, Pitt B, Hamilton AD, Sebti SM, Davies P. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells American Journal of Physiology - Lung Cellular and Molecular Physiology. 275. PMID 9688935 DOI: 10.1152/Ajplung.1998.275.1.L55  0.384
1998 Lazo JS, Kuo SM, Woo ES, Pitt BR. The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs. Chemico-Biological Interactions. 255-62. PMID 9679559 DOI: 10.1016/S0009-2797(97)00165-8  0.404
1997 Pitt BR, Schwarz M, Woo ES, Yee E, Wasserloos K, Tran S, Weng W, Mannix RJ, Watkins SA, Tyurina YY, Tyurin VA, Kagan VE, Lazo JS. Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 273: L856-L865. PMID 29585845 DOI: 10.1152/ajplung.1997.273.4.L856  0.317
1997 Pitt BR, Schwarz M, Woo ES, Yee E, Wasserloos K, Tran S, Weng W, Mannix RJ, Watkins SA, Tyurina YY, Tyurin VA, Kagan VE, Lazo JS. Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury. The American Journal of Physiology. 273: L856-65. PMID 9357862 DOI: 10.1152/Ajplung.1997.273.4.L856  0.424
1997 Hoyt DG, Rizzo M, Gerritsen ME, Pitt BR, Lazo JS. Integrin activation protects pulmonary endothelial cells from the genotoxic effects of bleomycin. The American Journal of Physiology. 273: L612-7. PMID 9316496 DOI: 10.1152/Ajplung.1997.273.3.L612  0.334
1997 Tzeng E, Kim YM, Pitt BR, Lizonova A, Kovesdi I, Billiar TR. Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis. Surgery. 122: 255-63. PMID 9288130 DOI: 10.1016/S0039-6060(97)90016-7  0.38
1997 Kondo Y, Rusnak JM, Hoyt DG, Settineri CE, Pitt BR, Lazo JS. Enhanced apoptosis in metallothionein null cells. Molecular Pharmacology. 52: 195-201. PMID 9271341 DOI: 10.1124/Mol.52.2.195  0.378
1997 Pitt BR, Robbins PD. Retrovirus-mediated gene therapy to fetal lung. Molecular Human Reproduction. 2: 467-9. PMID 9239652 DOI: 10.1093/Molehr/2.7.467  0.311
1997 Wong HR, Mannix RJ, Rusnak JM, Boota A, Zar H, Watkins SC, Lazo JS, Pitt BR. The heat-shock response attenuates lipopolysaccharide-mediated apoptosis in cultured sheep pulmonary artery endothelial cells. American Journal of Respiratory Cell and Molecular Biology. 15: 745-51. PMID 8969269 DOI: 10.1165/Ajrcmb.15.6.8969269  0.383
1997 Baker PN, Davidge ST, Pitt BR, Davies P, Roberts JM. Plasma from Preeclamptic Women Causes a Rapid, Calcium-Sensitive Release of Nitric Oxide from Vascular Smooth Muscle Cells Hypertension in Pregnancy. 16: 47-63. DOI: 10.3109/10641959709069089  0.321
1996 Boota A, Zar H, Kim YM, Johnson B, Pitt B, Davies P. IL-1 beta stimulates superoxide and delayed peroxynitrite production by pulmonary vascular smooth muscle cells American Journal of Physiology-Lung Cellular and Molecular Physiology. 271. PMID 8997263 DOI: 10.1152/Ajplung.1996.271.6.L932  0.322
1996 Hoyt DG, Mannix RJ, Gerritsen ME, Watkins SC, Lazo JS, Pitt BR. Integrins inhibit LPS-induced DNA strand breakage in cultured lung endothelial cells. The American Journal of Physiology. 270: L689-94. PMID 8928830 DOI: 10.1152/Ajplung.1996.270.4.L689  0.361
1996 Yee EL, Pitt BR, Billiar TR, Kim YM. Effect of nitric oxide on heme metabolism in pulmonary artery endothelial cells. The American Journal of Physiology. 271: L512-8. PMID 8897897 DOI: 10.1152/Ajplung.1996.271.4.L512  0.411
1996 Wong HR, Finder JD, Wasserloos K, Lowenstein CJ, Geller DA, Billiar TR, Pitt BR, Davies P. Transcriptional regulation of iNOS by IL-1 beta in cultured rat pulmonary artery smooth muscle cells. The American Journal of Physiology. 271: L166-71. PMID 8760147 DOI: 10.1152/Ajplung.1996.271.1.L166  0.307
1996 Harbrecht BG, Shears L, Pitt B, Billiar TR. PGI2 REGULATES NITRIC OXIDE SYNTHESIS IN RAT PULMONARY ARTERY VASCULAR SMOOTH MUSCLE Shock. 5: 57. DOI: 10.1097/00024382-199606002-00181  0.34
1996 Tzeng E, Shears LL, Robbins PD, Pitt BR, Geller DA, Watkins SC, Simmons RL, Billiar TR. Vascular Gene Transfer of the Human Inducible Nitric Oxide Synthase: Characterization of Activity and Effects on Myointimal Hyperplasia Molecular Medicine. 2: 211-225. DOI: 10.1007/Bf03401618  0.378
1995 Wong HR, Finder JD, Wasserloos K, Pitt BR. Expression of iNOS in cultured rat pulmonary artery smooth muscle cells is inhibited by the heat shock response. The American Journal of Physiology. 269: L843-8. PMID 8572246 DOI: 10.1152/Ajplung.1995.269.6.L843  0.302
1995 Kim YM, Bergonia HA, Müller C, Pitt BR, Watkins WD, Lancaster JR. Nitric oxide and intracellular heme. Advances in Pharmacology (San Diego, Calif.). 34: 277-91. PMID 8562440 DOI: 10.1016/S1054-3589(08)61092-3  0.323
1995 Kim YM, Bergonia HA, Müller C, Pitt BR, Watkins WD, Lancaster JR. Loss and degradation of enzyme-bound heme induced by cellular nitric oxide synthesis. The Journal of Biological Chemistry. 270: 5710-3. PMID 7890697 DOI: 10.1074/Jbc.270.11.5710  0.315
1995 Lazo JS, Kondo Y, Dellapiazza D, Michalska AE, Choo KH, Pitt BR. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. The Journal of Biological Chemistry. 270: 5506-10. PMID 7890668 DOI: 10.1074/Jbc.270.10.5506  0.373
1995 Tyurina YY, Tyurin VA, Yalowich JC, Quinn PJ, Claycamp HG, Schor NF, Pitt BR, Kagan VE. Phenoxyl Radicals of Etoposide (VP-16) Can Directly Oxidize Intracellular Thiols: Protective Versus Damaging Effects of Phenolic Antioxidants Toxicology and Applied Pharmacology. 131: 277-288. PMID 7716769 DOI: 10.1006/Taap.1995.1070  0.303
1995 Wong HR, Pitt BR, Su GL, Rossignol DP, Steve AR, Billiar TR, Wang SC. Induction of lipopolysaccharide-binding protein gene expression in cultured rat pulmonary artery smooth muscle cells by interleukin 1 beta. American Journal of Respiratory Cell and Molecular Biology. 12: 449-54. PMID 7695925 DOI: 10.1165/Ajrcmb.12.4.7695925  0.361
1995 Hoyt DG, Mannix RJ, Rusnak JM, Pitt BR, Lazo JS. Collagen is a survival factor against LPS-induced apoptosis in cultured sheep pulmonary artery endothelial cells. The American Journal of Physiology. 269: L171-7. PMID 7653577 DOI: 10.1152/Ajplung.1995.269.2.L171  0.381
1995 Thomae KR, Nakayama DK, Billiar TR, Simmons RL, Pitt BR, Davies P. The effect of nitric oxide on fetal pulmonary artery smooth muscle growth. The Journal of Surgical Research. 59: 337-43. PMID 7643591 DOI: 10.1006/Jsre.1995.1173  0.379
1995 Lazo JS, Pitt BR. Metallothioneins and cell death by anticancer drugs. Annual Review of Pharmacology and Toxicology. 35: 635-53. PMID 7598510 DOI: 10.1146/Annurev.Pa.35.040195.003223  0.326
1995 Gutierrez HH, Pitt BR, Schwarz M, Watkins SC, Lowenstein C, Caniggia I, Chumley P, Freeman BA. Pulmonary alveolar epithelial inducible NO synthase gene expression: regulation by inflammatory mediators. The American Journal of Physiology. 268: L501-8. PMID 7534997 DOI: 10.1152/Ajplung.1995.268.3.L501  0.452
1995 Wong HR, Finder J, Geller D, Billiar TR, Davies P, Pitt BR. THE 5ʼ FLANKING PROMOTER REGION OF MURINE INDUCIBLE NITRIC OXIDE SYNTHASE GENE MEDIATES INDUCTION BY INTERLEUKIN-1β IN CULTURED RAT PULMONARY ARTERY SMOOTH MUSCLE CELLS Critical Care Medicine. 23: A229. DOI: 10.1097/00003246-199501001-00403  0.365
1995 Wong HR, Pitt BR. INDUCTION OF iNOS GENE EXPRESSION VIA INTERLEUKIN-1β IN CULTURED RAT PULMONARY ARTERY SMOOTH MUSCLE CELLS IS INHIBITED BY ARSENITE INDUCED HEAT SHOCK RESPONSE Critical Care Medicine. 23: A229. DOI: 10.1097/00003246-199501001-00402  0.339
1994 Weng W, Reynolds IJ, Jani JP, Blaskovich M, Sebti SM, Davies P, Pitt BR. Desensitization of 5HT2 receptors by protein kinase C activation in distal pulmonary vascular smooth muscle cells in culture. Microcirculation (New York, N.Y. : 1994). 1: 129-35. PMID 8790584 DOI: 10.3109/10739689409148268  0.336
1994 Evans RR, Calmels TP, Pitt BR, Brookens MA, Johnson CS, Modzelewski RA, Lazo JS. Gene therapy and endothelial cell targeting for cancer Annals of the New York Academy of Sciences. 716: 257-264. PMID 7517652 DOI: 10.1111/J.1749-6632.1994.Tb21717.X  0.31
1994 Johnson BA, Lowenstein CJ, Schwarz MA, Nakayama DK, Pitt BR, Davies P. Culture of pulmonary microvascular smooth muscle cells from intraacinar arteries of the rat: characterization and inducible production of nitric oxide. American Journal of Respiratory Cell and Molecular Biology. 10: 604-12. PMID 7516171 DOI: 10.1165/Ajrcmb.10.6.7516171  0.422
1994 Wong HR, Pitt BR, Su GL, Billiar TR, Wang SC. INDUCTION OF LIPOPOLYSACCHARIDE BINDING PROTEIN mRNA IN CULTURED RAT PULMONARY ARTERY SMOOTH MUSCLE CELLS BY INTERLEUKIN-l?? Critical Care Medicine. 22: A121. DOI: 10.1097/00003246-199401000-00228  0.341
1992 Kubiak J, Mitra MM, Steve AR, Hunt JD, Davies P, Pitt BR. Transforming growth factor-alpha gene expression in late-gestation fetal rat lung. Pediatric Research. 31: 286-90. PMID 1561017 DOI: 10.1203/00006450-199203000-00019  0.31
1992 Pitt BR, Brookens MA, Steve AR, Atlas AB, Davies P, Kuo SM, Lazo JS. Expression of pulmonary metallothionein genes in late gestational lambs. Pediatric Research. 32: 424-30. PMID 1437395 DOI: 10.1203/00006450-199210000-00011  0.388
1992 Nakayama DK, Geller DA, Lowenstein CJ, Chern HD, Davies P, Pitt BR, Simmons RL, Billiar TR. Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle. American Journal of Respiratory Cell and Molecular Biology. 7: 471-6. PMID 1384580 DOI: 10.1165/Ajrcmb/7.5.471  0.382
1991 Pitt BR, Lister G, Pérez Fontán JJ, Davies P. Functional assessment of pulmonary capillary surface area in the 2-mo-old lamb. Journal of Applied Physiology (Bethesda, Md. : 1985). 70: 1677-85. PMID 1711522 DOI: 10.1152/Jappl.1991.70.4.1677  0.315
1990 Weng W, Pitt BR. Activation of protein kinase C inhibits extraction of serotonin by perfused rat lung in situ American Journal of Physiology - Lung Cellular and Molecular Physiology. 258. PMID 2360642 DOI: 10.1152/Ajplung.1990.258.6.L289  0.345
1990 Lazo JS, Hoyt DG, Sebti SM, Pitt BR. Bleomycin: A pharmacologic tool in the study of the pathogenesis of interstitial pulmonary fibrosis Pharmacology and Therapeutics. 47: 347-358. PMID 1705351 DOI: 10.1016/0163-7258(90)90061-6  0.37
1989 Havill AM, Riggs D, Pitt BR, Gillis CN. Resolution of impaired pulmonary function and pulmonary hypertension after phorbol ester administration in rabbits American Review of Respiratory Disease. 140: 782-788. PMID 2551205 DOI: 10.1164/Ajrccm/140.3.782  0.354
1988 Riggs D, Havill AM, Pitt BR, Gillis CN. Pulmonary angiotensin-converting enzyme kinetics after acute lung injury in the rabbit Journal of Applied Physiology. 64: 2508-2516. PMID 2841274 DOI: 10.1152/Jappl.1988.64.6.2508  0.318
1987 Pitt BR, Ryan JW, Chung AY, Woodford M, Yeates DB, Gillis CN. In-line measurement of pulmonary metabolic function in the anesthetized rabbit Journal of Applied Physiology. 62: 2500-2506. PMID 3610941 DOI: 10.1152/Jappl.1987.62.6.2500  0.364
1982 Gillis CN, Pitt BR. The fate of circulating amines within the pulmonary circulation Annual Review of Physiology. 44: 269-281. PMID 7041795 DOI: 10.1146/Annurev.Ph.44.030182.001413  0.386
1981 Yeates DB, Pitt BR, Spektor DM, Karron GA, Albert RE. Coordination of mucociliary transport in human trachea and intrapulmonary airways. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 51: 1057-64. PMID 7298443 DOI: 10.1152/Jappl.1981.51.5.1057  0.311
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