| Year |
Citation |
Score |
| 2024 |
van Veen BC, Clayden J. Intramolecular Nucleophilic Vinylic Substitution (SNV) by Carbon Nucleophiles: Conformationally Directed Formation of Dienes from N,N'-Diallyl Ureas. Chemistry (Weinheim An Der Bergstrasse, Germany). e202402352. PMID 38963681 DOI: 10.1002/chem.202402352 |
0.375 |
|
| 2024 |
Jesani MH, Schwarz M, Kim S, Evans FL, White A, Browning A, Abrams R, Clayden J. Selective defluorination of trifluoromethyl substituents by conformationally induced remote substitution. Angewandte Chemie (International Ed. in English). e202403477. PMID 38587304 DOI: 10.1002/anie.202403477 |
0.326 |
|
| 2024 |
Mallick RK, Žabka M, Clayden J. Benzo-fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re-contraction of Cyclic Ureas. Angewandte Chemie (International Ed. in English). e202318417. PMID 38261257 DOI: 10.1002/anie.202318417 |
0.352 |
|
| 2023 |
Morris DTJ, Wales SM, Echavarren J, Žabka M, Marsico G, Ward JW, Pridmore NE, Clayden J. Dynamic and Persistent Cyclochirality in Hydrogen-Bonded Derivatives of Medium-Ring Triamines. Journal of the American Chemical Society. 145: 19030-19041. PMID 37594473 DOI: 10.1021/jacs.3c06570 |
0.465 |
|
| 2023 |
Stammers E, Parsons CD, Clayden J, Lennox AJJ. Electrochemical synthesis of biaryls by reductive extrusion from N,N'-diarylureas. Nature Communications. 14: 4561. PMID 37507363 DOI: 10.1038/s41467-023-40237-6 |
0.336 |
|
| 2023 |
Saunthwal RK, Schwarz M, Mallick RK, Terry-Wright W, Clayden J. Enantioselective Intramolecular α-Arylation of Benzylamine Derivatives: Synthesis of a Precursor to Levocetirizine. Angewandte Chemie (International Ed. in English). PMID 36698284 DOI: 10.1002/anie.202216758 |
0.762 |
|
| 2022 |
Watts OFB, Berreur J, Collins BSL, Clayden J. Biocatalytic Enantioselective Synthesis of Atropisomers. Accounts of Chemical Research. PMID 36343339 DOI: 10.1021/acs.accounts.2c00572 |
0.796 |
|
| 2022 |
Wales SM, Saunthwal RK, Clayden J. C(sp)-Arylation by Conformationally Accelerated Intramolecular Nucleophilic Aromatic Substitution (SAr). Accounts of Chemical Research. 55: 1731-1747. PMID 35620846 DOI: 10.1021/acs.accounts.2c00184 |
0.792 |
|
| 2022 |
Saunthwal RK, Mortimer J, Orr-Ewing AJ, Clayden J. Enantioselective one-carbon expansion of aromatic rings by simultaneous formation and chromoselective irradiation of a transient coloured enolate. Chemical Science. 13: 2079-2085. PMID 35308841 DOI: 10.1039/d1sc06684f |
0.765 |
|
| 2021 |
Eagling L, Leonard DJ, Schwarz M, Urruzuno I, Boden G, Wailes JS, Ward JW, Clayden J. 'Reverse biomimetic' synthesis of l-arogenate and its stabilized analogues from l-tyrosine. Chemical Science. 12: 11394-11398. PMID 34667547 DOI: 10.1039/d1sc03554a |
0.478 |
|
| 2021 |
Morris DTJ, Wales SM, Tilly DP, Farrar EHE, Grayson MN, Ward JW, Clayden J. A molecular communication channel consisting of a single reversible chain of hydrogen bonds in a conformationally flexible oligomer. Chem. 7: 2460-2472. PMID 34553103 DOI: 10.1016/j.chempr.2021.06.022 |
0.43 |
|
| 2021 |
Leonard DJ, Zieleniewski F, Wellhöfer I, Baker EG, Ward JW, Woolfson DN, Clayden J. Scalable synthesis and coupling of quaternary α-arylated amino acids: α-aryl substituents are tolerated in α-helical peptides. Chemical Science. 12: 9386-9390. PMID 34349911 DOI: 10.1039/d1sc01378e |
0.484 |
|
| 2021 |
Abrams R, Jesani MH, Browning A, Clayden J. Triarylmethanes and their Medium-Ring Analogues by Unactivated Truce-Smiles Rearrangement of Benzanilides. Angewandte Chemie (International Ed. in English). PMID 33830592 DOI: 10.1002/anie.202102192 |
0.345 |
|
| 2020 |
Millward MJ, Ellis E, Ward JW, Clayden J. Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds. Chemical Science. 12: 2091-2096. PMID 34163972 DOI: 10.1039/d0sc06188c |
0.548 |
|
| 2020 |
Millward MJ, Ellis E, Ward JW, Clayden J. Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds. Chemical Science. 12: 2091-2096. PMID 34163972 DOI: 10.1039/d0sc06188c |
0.332 |
|
| 2020 |
Aggarwal VK, Armstrong SK, Caggiano L, Chibale K, Clayden J, Coldham I, Greeves N, Hartley RC, Knight JG, Kuhnert N, Mitchell HJ, Nelson A, O'Brien P, Thomas SP, Wyatt P. Stuart Warren (24 Dec 1938-22 Mar 2020). Organic & Biomolecular Chemistry. PMID 32936190 DOI: 10.1039/D0Ob90121K |
0.73 |
|
| 2020 |
Zieleniewski F, Woolfson DN, Clayden J. Automated solid-phase concatenation of Aib residues to form long, water-soluble, helical peptides. Chemical Communications (Cambridge, England). PMID 32902536 DOI: 10.1039/D0Cc04698A |
0.337 |
|
| 2020 |
Costil R, Sterling AJ, Duarte F, Clayden J. Atropisomerism in diarylamines: structural requirements and mechanisms of conformational interconversion. Angewandte Chemie (International Ed. in English). PMID 32633101 DOI: 10.1002/Anie.202007595 |
0.36 |
|
| 2020 |
Abrams R, Clayden J. Photocatalytic Difunctionalization of Vinyl Ureas by Radical Addition Polar Truce-Smiles Rearrangement Cascades. Angewandte Chemie (International Ed. in English). PMID 32227575 DOI: 10.1002/Anie.202003632 |
0.397 |
|
| 2020 |
Eccles N, Della Sala F, Le Bailly BAF, Whitehead GFS, Clayden J, Webb SJ. Molecular Recognition by Zn(II)-Capped Dynamic Foldamers. Chemistryopen. 9: 338-345. PMID 32195074 DOI: 10.1002/Open.201900362 |
0.384 |
|
| 2019 |
Amer MM, Olaizola O, Carter J, Abas H, Clayden J. An Aliphatic Bischler-Napieralski Reaction: Dihydropyridones by Cyclocarbonylation of 3-Allylimidazolidin-4-ones. Organic Letters. PMID 31846338 DOI: 10.1021/Acs.Orglett.9B04250 |
0.417 |
|
| 2019 |
Clayden J. Fluorinated compounds present opportunities for drug discovery. Nature. 573: 37-38. PMID 31485062 DOI: 10.1038/D41586-019-02611-7 |
0.318 |
|
| 2019 |
Eccles N, Le Bailly BAF, Della Sala F, Vitórica-Yrezábal IJ, Clayden J, Webb SJ. Remote conformational responses to enantiomeric excess in carboxylate-binding dynamic foldamers. Chemical Communications (Cambridge, England). PMID 31313773 DOI: 10.1039/C9Cc03895G |
0.318 |
|
| 2019 |
Amer MM, Abas H, Leonard DJ, Ward JW, Clayden J. Amino acid-derived trans-N-chloroformylimidazolidinones: scalable, stereoselective synthesis, structure, and utility. The Journal of Organic Chemistry. PMID 31090419 DOI: 10.1021/Acs.Joc.9B00727 |
0.613 |
|
| 2019 |
Saunthwal RK, Cornall MT, Abrams R, Ward JW, Clayden J. Connective synthesis of 5,5-disubstituted hydantoins by tandem α-amination and α-arylation of silyl ketene acetals. Chemical Science. 10: 3408-3412. PMID 30996929 DOI: 10.1039/C8Sc05263H |
0.816 |
|
| 2019 |
De Zotti M, Clayden J. Extended Diethylglycine Homopeptides Formed by Desulfurization of Their Tetrahydrothiopyran Analogues. Organic Letters. PMID 30859838 DOI: 10.1021/Acs.Orglett.9B00501 |
0.313 |
|
| 2019 |
Abas H, Amer MM, Olaizola O, Clayden J. N-Chloroformylimidazolidinone Enolates as 1,3-Dipolar Reagents for the Stereoselective Synthesis of 3,4-Dihydroisoquinolones. Organic Letters. PMID 30802074 DOI: 10.1021/Acs.Orglett.9B00548 |
0.498 |
|
| 2019 |
Abas H, Mas-Roselló J, Amer MM, Durand DJ, Groleau RR, Fey N, Clayden J. Asymmetric and Geometry-selective α-Alkenylation of α-Amino Acids. Angewandte Chemie (International Ed. in English). PMID 30600901 DOI: 10.1002/Anie.201813984 |
0.427 |
|
| 2018 |
Zawodny W, Marshall JR, Finnigan JD, Turner NJ, Clayden J, Montgomery SL. Chemoenzymatic synthesis of substituted azepanes by sequential biocatalytic reduction and organolithium-mediated rearrangement. Journal of the American Chemical Society. PMID 30521324 DOI: 10.1021/Jacs.8B11891 |
0.477 |
|
| 2018 |
Amer MM, Carrasco AC, Leonard DJ, Ward JW, Clayden J. Substituted Dihydroisoquinolinones by Iodide-Promoted Cyclocarbonylation of Aromatic α-Amino Acids. Organic Letters. PMID 30516389 DOI: 10.1021/Acs.Orglett.8B03551 |
0.577 |
|
| 2018 |
Lister FGA, Eccles N, Pike SJ, Brown RA, Whitehead GFS, Raftery J, Webb SJ, Clayden J. Bis-pyrene probes of foldamer conformation in solution and in phospholipid bilayers. Chemical Science. 9: 6860-6870. PMID 30310619 DOI: 10.1039/C8Sc02532K |
0.358 |
|
| 2018 |
Leonard DJ, Ward JW, Clayden J. Asymmetric α-arylation of amino acids. Nature. 562: 105-109. PMID 30283103 DOI: 10.1038/S41586-018-0553-9 |
0.569 |
|
| 2018 |
Mas-Roselló J, Okoh M, Clayden J. Enantioselectively functionalised phenytoin derivatives by auxiliary-directed N to C aryl migration in lithiated α-amino nitriles. Chemical Communications (Cambridge, England). PMID 30211399 DOI: 10.1039/C8Cc06833J |
0.463 |
|
| 2018 |
Hill JE, Lefebvre Q, Fraser LA, Clayden J. Polycyclic Indoline Derivatives by Dearomatizing Anionic Cyclization of Indole and Tryptamine-Derived Ureas. Organic Letters. PMID 30203980 DOI: 10.1021/Acs.Orglett.8B02468 |
0.433 |
|
| 2018 |
Abrams R, Lefebvre Q, Clayden J. Transition Metal-Free Cycloamination of Prenyl Carbamates and Ureas Promoted by Aryldiazonium Salts. Angewandte Chemie (International Ed. in English). PMID 30168287 DOI: 10.1002/Anie.201809323 |
0.37 |
|
| 2018 |
Lizio MG, Andrushchenko V, Pike SJ, Peters AD, Whitehead GFS, Vitórica-Yrezábal IJ, Mutter ST, Clayden J, Bouř P, Blanch EW, Webb SJ. Optically-Active Vibrational Spectroscopy of α-Aminoisobutyric Acid Foldamers in Organic Solvents and Phospholipid Bilayers. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29745985 DOI: 10.1002/Chem.201801121 |
0.32 |
|
| 2018 |
Costil R, Fernández-Nieto F, Atkinson RC, Clayden J. α-Methyl phenylglycines by asymmetric α-arylation of alanine and their effect on the conformational preference of helical Aib foldamers. Organic & Biomolecular Chemistry. PMID 29595846 DOI: 10.1039/C8Ob00551F |
0.396 |
|
| 2018 |
Hill J, Matlock J, Lefebvre Q, Cooper K, Clayden J. Ring expansion and re-contraction for the synthesis of 1-aryl tetrahydroisoquinolines and tetrahydrobenzazepines from readily available heterocyclic precursors. Angewandte Chemie (International Ed. in English). PMID 29539221 DOI: 10.1002/Anie.201802188 |
0.412 |
|
| 2018 |
Wechsel R, Žabka M, Ward JW, Clayden J. Competing Hydrogen-Bond Polarities in a Dynamic Oligourea Foldamer: A Molecular Spring Torsion Balance. Journal of the American Chemical Society. PMID 29494138 DOI: 10.1021/Jacs.8B00567 |
0.505 |
|
| 2017 |
Adam C, Peters AD, Lizio MG, Whitehead GFS, Diemer V, Cooper JA, Cockroft SL, Clayden J, Webb SJ. The Role of Terminal Functionality in the Membrane and Antibacterial Activity of Peptaibol-Mimetic Aib Foldamers. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29210477 DOI: 10.1002/Chem.201705299 |
0.335 |
|
| 2017 |
Costil R, Lefebvre Q, Clayden J. Medium-ring analogues of dibenzodiazepines by conformationally induced Smiles ring expansion. Angewandte Chemie (International Ed. in English). PMID 28967697 DOI: 10.1002/Anie.201708991 |
0.402 |
|
| 2017 |
Diemer V, Maury J, Le Bailly BAF, Webb SJ, Clayden J. Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers. Chemical Communications (Cambridge, England). PMID 28875189 DOI: 10.1039/C7Cc06427F |
0.302 |
|
| 2017 |
Costil R, Dale H, Fey N, Whitcombe G, Matlock J, Clayden J. Heavily Substituted Atropisomeric Diarylamines by Unactivated Smiles Rearrangement of N-Aryl Anthranilamides. Angewandte Chemie (International Ed. in English). PMID 28817222 DOI: 10.1002/Anie.201706341 |
0.47 |
|
| 2017 |
Mas-Roselló J, Hachisu S, Clayden J. Geometry-retentive C-alkenylation of lithiated α-aminonitriles: quaternary α-alkenyl amino acids and hydantoins. Angewandte Chemie (International Ed. in English). PMID 28649795 DOI: 10.1002/Anie.201704908 |
0.464 |
|
| 2017 |
Tomsett M, Maffucci I, Le Bailly BAF, Byrne L, Bijvoets SM, Lizio MG, Raftery J, Butts CP, Webb SJ, Contini A, Clayden J. A tendril perversion in a helical oligomer: trapping and characterizing a mobile screw-sense reversal. Chemical Science. 8: 3007-3018. PMID 28451368 DOI: 10.1039/C6Sc05474A |
0.323 |
|
| 2017 |
Gratzer K, Diemer V, Clayden J. Signal transduction in oligoamide foldamers by selective non-covalent binding of chiral phosphates at a urea binding site. Organic & Biomolecular Chemistry. PMID 28397923 DOI: 10.1039/C7Ob00660H |
0.3 |
|
| 2017 |
Maury J, Zawodny W, Clayden J. Stereospecific Intramolecular Arylation of 2- and 3-Pyridyl Substituted Alkylamines via Configurationally Stable α-Pyridyl Organolithiums. Organic Letters. PMID 28099031 DOI: 10.1021/Acs.Orglett.6B03603 |
0.475 |
|
| 2017 |
Corbet BP, Matlock JV, Mas-Roselló J, Clayden J. Intramolecular vinylation of carbanions using N -acyl benzomorpholines as masked vinylureas and vinylcarbamates Comptes Rendus Chimie. 20: 634-642. DOI: 10.1016/J.Crci.2017.01.006 |
0.477 |
|
| 2016 |
Staniland S, Adams RW, McDouall JJ, Maffucci I, Contini A, Grainger DM, Turner NJ, Clayden J. Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts. Angewandte Chemie (International Ed. in English). PMID 27504722 DOI: 10.1002/Anie.201605486 |
0.431 |
|
| 2016 |
Hall JE, Matlock JV, Ward JW, Gray KV, Clayden J. Medium-Ring Nitrogen Heterocycles through Migratory Ring Expansion of Metalated Ureas. Angewandte Chemie (International Ed. in English). PMID 27440757 DOI: 10.1002/Anie.201605714 |
0.604 |
|
| 2016 |
Wechsel R, Raftery J, Cavagnat D, Guichard G, Clayden J. The meso Helix: Symmetry and Symmetry-Breaking in Dynamic Oligourea Foldamers with Reversible Hydrogen-Bond Polarity. Angewandte Chemie (International Ed. in English). PMID 27298097 DOI: 10.1002/Anie.201604496 |
0.37 |
|
| 2016 |
Mazzier D, Crisma M, De Poli M, Marafon G, Peggion C, Clayden J, Moretto A. Helical foldamers incorporating photoswitchable residues for light-mediated modulation of conformational preference. Journal of the American Chemical Society. PMID 27258674 DOI: 10.1021/Jacs.6B04435 |
0.338 |
|
| 2016 |
Le Bailly BA, Byrne L, Clayden J. Refoldable Foldamers: Global Conformational Switching by Deletion or Insertion of a Single Hydrogen Bond. Angewandte Chemie (International Ed. in English). PMID 26762559 DOI: 10.1002/Anie.201510605 |
0.344 |
|
| 2016 |
Roselló JM, Staniland S, Turner NJ, Clayden J. Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation Tetrahedron. 72: 5172-5177. DOI: 10.1016/J.Tet.2016.01.037 |
0.435 |
|
| 2015 |
Le Bailly BAF, Byrne L, Diemer V, Foroozandeh M, Morris GA, Clayden J. Flaws in foldamers: conformational uniformity and signal decay in achiral helical peptide oligomers. Chemical Science. 6: 2313-2322. PMID 29308146 DOI: 10.1039/C4Sc03944K |
0.36 |
|
| 2015 |
Maffucci I, Clayden J, Contini A. Origin of Helical Screw Sense Selectivity Induced by Chiral Constrained Cα-Tetrasubstituted α-Amino Acids in Aib-based Peptides. The Journal of Physical Chemistry. B. 119: 14003-13. PMID 26457452 DOI: 10.1021/Acs.Jpcb.5B07050 |
0.34 |
|
| 2015 |
Maury J, Clayden J. α-Quaternary Proline Derivatives by Intramolecular Diastereoselective Arylation of N-Carboxamido Proline Ester Enolates. The Journal of Organic Chemistry. 80: 10757-68. PMID 26421443 DOI: 10.1021/Acs.Joc.5B01912 |
0.387 |
|
| 2015 |
Fernández-Nieto F, Mas Roselló J, Lenoir S, Hardy S, Clayden J. Palladium Catalyzed C-Arylation of Amino Acid Derived Hydantoins. Organic Letters. 17: 3838-41. PMID 26200165 DOI: 10.1021/Acs.Orglett.5B01803 |
0.442 |
|
| 2015 |
Maury J, Le Bailly BA, Raftery J, Clayden J. Conformational cooperativity between helical domains of differing geometry in oligoamide-oligourea foldamer chimeras. Chemical Communications (Cambridge, England). PMID 26107614 DOI: 10.1039/C5Cc02995C |
0.373 |
|
| 2015 |
Atkinson RC, Fernández-Nieto F, Mas Roselló J, Clayden J. Pseudoephedrine-Directed Asymmetric α-Arylation of α-Amino Acid Derivatives. Angewandte Chemie (International Ed. in English). PMID 26083236 DOI: 10.1002/anie.201502569 |
0.322 |
|
| 2015 |
Byrne L, Solà J, Clayden J. Screw sense alone can govern enantioselective extension of a helical peptide by kinetic resolution of a racemic amino acid. Chemical Communications (Cambridge, England). 51: 10965-8. PMID 26062815 DOI: 10.1039/C5Cc01790D |
0.595 |
|
| 2015 |
Brioche J, Pike SJ, Tshepelevitsh S, Leito I, Morris GA, Webb SJ, Clayden J. Conformational Switching of a Foldamer in a Multicomponent System by pH-Filtered Selection between Competing Noncovalent Interactions. Journal of the American Chemical Society. 137: 6680-91. PMID 25915163 DOI: 10.1021/Jacs.5B03284 |
0.774 |
|
| 2015 |
Tait MB, Butterworth S, Clayden J. 2,2- and 2,6-Diarylpiperidines by aryl migration within lithiated urea derivatives of tetrahydropyridines. Organic Letters. 17: 1236-9. PMID 25692395 DOI: 10.1021/Acs.Orglett.5B00199 |
0.464 |
|
| 2015 |
Castagnolo D, Degennaro L, Luisi R, Clayden J. Enantioselective carbolithiation of S-alkenyl-N-aryl thiocarbamates: kinetic and thermodynamic control. Organic & Biomolecular Chemistry. 13: 2330-40. PMID 25562487 DOI: 10.1039/C4Ob02329C |
0.444 |
|
| 2015 |
Maffucci I, Pellegrino S, Clayden J, Contini A. Mechanism of stabilization of helix secondary structure by constrained Cα-tetrasubstituted α-amino acids. The Journal of Physical Chemistry. B. 119: 1350-61. PMID 25528885 DOI: 10.1021/Jp510775E |
0.335 |
|
| 2015 |
Pike SJ, Boddaert T, Raftery J, Webb SJ, Clayden J. Participation of non-aminoisobutyric acid (Aib) residues in the 310 helical conformation of Aib-rich foldamers: A solid state study New Journal of Chemistry. 39: 3288-3294. DOI: 10.1039/C4Nj01547A |
0.744 |
|
| 2015 |
Day BM, McDouall JJW, Clayden J, Layfield RA. Directed Lithiation of Pentadienylsilanes Organometallics. 34: 2348-2355. DOI: 10.1021/Om501144F |
0.348 |
|
| 2015 |
Vincent MA, Maury J, Hillier IH, Clayden J. Lithium choreography determines contrasting stereochemical outcomes of aryl migrations in benzylic carbamates, ureas and thiocarbamates European Journal of Organic Chemistry. 2015: 953-959. DOI: 10.1002/Ejoc.201403572 |
0.393 |
|
| 2014 |
Wechsel R, Maury J, Fremaux J, France SP, Guichard G, Clayden J. Inducing achiral aliphatic oligoureas to fold into helical conformations. Chemical Communications (Cambridge, England). 50: 15006-9. PMID 25327885 DOI: 10.1039/C4Cc06754A |
0.362 |
|
| 2014 |
Pike SJ, Diemer V, Raftery J, Webb SJ, Clayden J. Designing foldamer-foldamer interactions in solution: the roles of helix length and terminus functionality in promoting the self-association of aminoisobutyric acid oligomers. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 15981-90. PMID 25280242 DOI: 10.1002/Chem.201403626 |
0.339 |
|
| 2014 |
Staniland S, Yuan B, Giménez-Agulló N, Marcelli T, Willies SC, Grainger DM, Turner NJ, Clayden J. Enzymatic desymmetrising redox reactions for the asymmetric synthesis of biaryl atropisomers. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 13084-8. PMID 25156181 DOI: 10.1002/Chem.201404509 |
0.345 |
|
| 2014 |
Berber H, Lameiras P, Denhez C, Antheaume C, Clayden J. Atropisomerism about aryl-Csp(3) bonds: the electronic and steric influence of ortho-substituents on conformational exchange in cannabidiol and linderatin derivatives. The Journal of Organic Chemistry. 79: 6015-27. PMID 24919056 DOI: 10.1021/Jo5006069 |
0.407 |
|
| 2014 |
Le Bailly BA, Clayden J. Controlling the sign and magnitude of screw-sense preference from the C-terminus of an achiral helical foldamer. Chemical Communications (Cambridge, England). 50: 7949-52. PMID 24918692 DOI: 10.1039/C4Cc03261F |
0.374 |
|
| 2014 |
Pike SJ, Raftery J, Webb SJ, Clayden J. Conformational analysis of helical aminoisobutyric acid (Aib) oligomers bearing C-terminal ester Schellman motifs. Organic & Biomolecular Chemistry. 12: 4124-31. PMID 24831537 DOI: 10.1039/C4Ob00268G |
0.364 |
|
| 2014 |
Mingat G, McDouall JJ, Clayden J. Dihydrothiophenes containing quaternary stereogenic centres by sequential stereospecific rearrangements and ring-closing metathesis. Chemical Communications (Cambridge, England). 50: 6754-7. PMID 24831495 DOI: 10.1039/C4Cc02596B |
0.431 |
|
| 2014 |
De Poli M, Byrne L, Brown RA, Solà J, Castellanos A, Boddaert T, Wechsel R, Beadle JD, Clayden J. Engineering the structure of an N-terminal β-turn to maximize screw-sense preference in achiral helical peptide chains. The Journal of Organic Chemistry. 79: 4659-75. PMID 24708302 DOI: 10.1021/Jo500714B |
0.802 |
|
| 2014 |
Mingat G, MacLellan P, Laars M, Clayden J. Tertiary thiols from allylic thiocarbamates by tandem enantioselective [3,3]-sigmatropic rearrangement and stereospecific arylation. Organic Letters. 16: 1252-5. PMID 24502387 DOI: 10.1021/Ol5002522 |
0.485 |
|
| 2014 |
Byrne L, Solà J, Boddaert T, Marcelli T, Adams RW, Morris GA, Clayden J. Foldamer-mediated remote stereocontrol: >1,60 asymmetric induction. Angewandte Chemie (International Ed. in English). 53: 151-5. PMID 24375739 DOI: 10.1002/Anie.201308264 |
0.796 |
|
| 2014 |
De Poli M, Clayden J. Thionoglycine as a multifunctional spectroscopic reporter of screw-sense preference in helical foldamers. Organic & Biomolecular Chemistry. 12: 836-43. PMID 24336870 DOI: 10.1039/C3Ob42167H |
0.321 |
|
| 2014 |
Tait MB, Ottersbach PA, Tetlow DJ, Clayden J. Synthesis of 1-arylcycloalkenamines by intramolecular arylation of lithiated ureas Organic Process Research and Development. 18: 1245-1252. DOI: 10.1021/Op500173Q |
0.796 |
|
| 2014 |
Fleary-Roberts N, Lemière G, Clayden J. Geometry-selective synthesis of the unsaturated side chains of the isodomoic acids Tetrahedron. DOI: 10.1016/J.Tet.2015.02.055 |
0.772 |
|
| 2014 |
Clayden J. Dearomatization and Aryl Migration in Organolithium Chemistry Lithium Compounds in Organic Synthesis: From Fundamentals to Applications. 375-396. DOI: 10.1002/9783527667512.Ch13 |
0.321 |
|
| 2013 |
Orcel U, De Poli M, De Zotti M, Clayden J. The N-terminal nonapeptide of cephaibols A and C: a naturally occurring example of mismatched helical screw-sense control. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 16357-65. PMID 24123376 DOI: 10.1002/Chem.201302648 |
0.404 |
|
| 2013 |
Atkinson RC, Leonard DJ, Maury J, Castagnolo D, Volz N, Clayden J. Intramolecular arylation of amino acid enolates. Chemical Communications (Cambridge, England). 49: 9734-6. PMID 24022183 DOI: 10.1039/C3Cc46193A |
0.46 |
|
| 2013 |
Fremaux J, Dolain C, Kauffmann B, Clayden J, Guichard G. Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers. Chemical Communications (Cambridge, England). 49: 7415-7. PMID 23862177 DOI: 10.1039/C3Cc40961A |
0.337 |
|
| 2013 |
Herbert SA, Castell DC, Clayden J, Arnott GE. Manipulating the diastereoselectivity of ortholithiation in planar chiral ferrocenes. Organic Letters. 15: 3334-7. PMID 23826677 DOI: 10.1021/Ol4013734 |
0.341 |
|
| 2013 |
Lefranc J, Minassi A, Clayden J. Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates. Beilstein Journal of Organic Chemistry. 9: 628-32. PMID 23616806 DOI: 10.3762/Bjoc.9.70 |
0.404 |
|
| 2013 |
Castagnolo D, Foley DJ, Berber H, Luisi R, Clayden J. Carbolithiation of S-alkenyl-N-aryl thiocarbamates: carbanion arylation in a connective route to tertiary thiols. Organic Letters. 15: 2116-9. PMID 23587101 DOI: 10.1021/Ol400570R |
0.469 |
|
| 2013 |
Pike SJ, De Poli M, Zawodny W, Raftery J, Webb SJ, Clayden J. Diastereotopic fluorine substituents as 19F NMR probes of screw-sense preference in helical foldamers. Organic & Biomolecular Chemistry. 11: 3168-76. PMID 23558640 DOI: 10.1039/C3Ob40463C |
0.335 |
|
| 2013 |
Senczyszyn J, Brice H, Clayden J. Spirocyclic dihydropyridines by electrophile-induced dearomatizing cyclization of N-alkenyl pyridinecarboxamides. Organic Letters. 15: 1922-5. PMID 23547947 DOI: 10.1021/Ol400571J |
0.419 |
|
| 2013 |
Tetlow DJ, Vincent MA, Hillier IH, Clayden J. Reversible aryl migrations in metallated ureas: controlled inversion of configuration at a quaternary carbon atom. Chemical Communications (Cambridge, England). 49: 1548-50. PMID 23324729 DOI: 10.1039/C2Cc38704B |
0.775 |
|
| 2013 |
De Poli M, De Zotti M, Raftery J, Aguilar JA, Morris GA, Clayden J. Left-handed helical preference in an achiral peptide chain is induced by an L-amino acid in an N-terminal type II β-turn. The Journal of Organic Chemistry. 78: 2248-55. PMID 23316729 DOI: 10.1021/Jo302705K |
0.353 |
|
| 2013 |
Tait M, Donnard M, Minassi A, Lefranc J, Bechi B, Carbone G, O'Brien P, Clayden J. Amines bearing tertiary substituents by tandem enantioselective carbolithiation-rearrangement of vinylureas. Organic Letters. 15: 34-7. PMID 23252812 DOI: 10.1021/Ol3029324 |
0.768 |
|
| 2013 |
Tait M, Donnard M, Minassi A, Lefranc J, Bechi B, Carbone G, O'Brien P, Clayden J. Erratum: Amines bearing tertiary substituents by tandem enantioselective carbolithiation - Rearrangement of vinylureas (Organic Letters (2013) 15 (34-37)) Organic Letters. 15: 974-976. DOI: 10.1021/Ol4002009 |
0.712 |
|
| 2013 |
Harvey RA, Karlubíková O, Parris S, Clayden J. Dearomatising cyclisation of lithiated allyl phenyl ethers: The role of an oxazoline substituent Tetrahedron Letters. 54: 4064-4066. DOI: 10.1016/J.Tetlet.2013.05.098 |
0.391 |
|
| 2012 |
Fournier AM, Nichols CJ, Vincent MA, Hillier IH, Clayden J. Lithium choreography: intramolecular arylations of carbamate-stabilised carbanions and their mechanisms probed by in situ IR spectroscopy and DFT calculations. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 16478-90. PMID 23097264 DOI: 10.1002/Chem.201201761 |
0.433 |
|
| 2012 |
Vincent MA, Smith AC, Donnard M, Harford PJ, Haywood J, Hillier IH, Clayden J, Wheatley AE. Lithiated tertiary carbanions display variable coordination modes: evidence from DFT and NMR studies. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 11036-45. PMID 22807104 DOI: 10.1002/Chem.201200734 |
0.71 |
|
| 2012 |
Lefranc J, Fournier AM, Mingat G, Herbert S, Marcelli T, Clayden J. Intramolecular vinylation of secondary and tertiary organolithiums. Journal of the American Chemical Society. 134: 7286-9. PMID 22480365 DOI: 10.1021/ja301591m |
0.35 |
|
| 2012 |
Wheatley AE, Clayden J, Hillier IH, Campbell Smith A, Vincent MA, Taylor LJ, Haywood J. On the control of secondary carbanion structure utilising ligand effects during directed metallation. Beilstein Journal of Organic Chemistry. 8: 50-60. PMID 22423271 DOI: 10.3762/Bjoc.8.5 |
0.41 |
|
| 2012 |
Boddaert T, Solà J, Helliwell M, Clayden J. Chemical communication: conductors and insulators of screw-sense preference between helical oligo(aminoisobutyric acid) domains. Chemical Communications (Cambridge, England). 48: 3397-9. PMID 22363936 DOI: 10.1039/C2Cc00060A |
0.758 |
|
| 2012 |
Brown RA, Marcelli T, De Poli M, Solà J, Clayden J. Induction of unexpected left-handed helicity by an N-terminal L-amino acid in an otherwise achiral peptide chain. Angewandte Chemie (International Ed. in English). 51: 1395-9. PMID 22294355 DOI: 10.1002/Anie.201107583 |
0.583 |
|
| 2012 |
Burke EW, Morris GA, Vincent MA, Hillier IH, Clayden J. Is nevirapine atropisomeric? Experimental and computational evidence for rapid conformational inversion. Organic & Biomolecular Chemistry. 10: 716-9. PMID 22159411 DOI: 10.1039/C1Ob06490H |
0.312 |
|
| 2012 |
Fournier AM, Clayden J. Tertiary alcohols by tandem β-carbolithiation and N→C aryl migration in enol carbamates. Organic Letters. 14: 142-5. PMID 22126329 DOI: 10.1021/Ol2029355 |
0.47 |
|
| 2012 |
Mingat G, Clayden J. S-allyl thiocarbamates from allylic alcohols by in situ [3,3]-sigmatropic rearrangement of a thiocarbonyldiimidazole adduct Synthesis (Germany). 44: 2723-2734. DOI: 10.1055/S-0032-1316746 |
0.41 |
|
| 2012 |
Grainger DM, Campbell Smith A, Vincent MA, Hillier IH, Wheatley AEH, Clayden J. The mechanism of the stereospecific intramolecular arylation of lithiated ureas: The role of Li + probed by electronic structure calculations, and by NMR and IR spectroscopy European Journal of Organic Chemistry. 731-743. DOI: 10.1002/Ejoc.201101475 |
0.431 |
|
| 2011 |
Volz N, Clayden J. The urea renaissance. Angewandte Chemie (International Ed. in English). 50: 12148-55. PMID 22086455 DOI: 10.1002/Anie.201104037 |
0.345 |
|
| 2011 |
Page A, Clayden J. Carbamate-directed benzylic lithiation for the diastereo- and enantioselective synthesis of diaryl ether atropisomers. Beilstein Journal of Organic Chemistry. 7: 1327-33. PMID 22043243 DOI: 10.3762/Bjoc.7.156 |
0.338 |
|
| 2011 |
Fletcher SP, Solà J, Holt D, Brown RA, Clayden J. Synthesis of enantiomerically enriched (R)-C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine. Beilstein Journal of Organic Chemistry. 7: 1304-9. PMID 22043239 DOI: 10.3762/Bjoc.7.152 |
0.716 |
|
| 2011 |
Clayden J. Molecular devices: Communicating chirality. Nature Chemistry. 3: 842-3. PMID 22024878 DOI: 10.1038/Nchem.1181 |
0.318 |
|
| 2011 |
Smith AC, Donnard M, Haywood J, McPartlin M, Vincent MA, Hillier IH, Clayden J, Wheatley AE. Ligand effects in the formation of tertiary carbanions from substituted tertiary aromatic amides. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 8078-84. PMID 21647989 DOI: 10.1002/Chem.201100240 |
0.699 |
|
| 2011 |
Clayden J, Maclellan P. Asymmetric synthesis of tertiary thiols and thioethers. Beilstein Journal of Organic Chemistry. 7: 582-95. PMID 21647256 DOI: 10.3762/Bjoc.7.68 |
0.37 |
|
| 2011 |
Clayden J, Donnard M, Lefranc J, Tetlow DJ. Quaternary centres bearing nitrogen (α-tertiary amines) as products of molecular rearrangements. Chemical Communications (Cambridge, England). 47: 4624-39. PMID 21380444 DOI: 10.1039/C1Cc00049G |
0.804 |
|
| 2011 |
Solà J, Morris GA, Clayden J. Measuring screw-sense preference in a helical oligomer by comparison of 13C NMR signal separation at slow and fast exchange. Journal of the American Chemical Society. 133: 3712-5. PMID 21351795 DOI: 10.1021/Ja1097034 |
0.58 |
|
| 2011 |
Lemière G, Sedehizadeh S, Toueg J, Fleary-Roberts N, Clayden J. A general synthetic approach to the amnesic shellfish toxins: total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F. Chemical Communications (Cambridge, England). 47: 3745-7. PMID 21350768 DOI: 10.1039/C1Cc00048A |
0.749 |
|
| 2011 |
MacLellan P, Clayden J. Enantioselective synthesis of tertiary thiols by intramolecular arylation of lithiated thiocarbamates. Chemical Communications (Cambridge, England). 47: 3395-7. PMID 21331400 DOI: 10.1039/C0Cc04912C |
0.461 |
|
| 2011 |
Lefranc J, Tetlow DJ, Donnard M, Minassi A, Gálvez E, Clayden J. Geometry-selective synthesis of E or Z N-vinyl ureas (N-carbamoyl enamines). Organic Letters. 13: 296-9. PMID 21166427 DOI: 10.1021/Ol1027442 |
0.816 |
|
| 2011 |
Solà J, Helliwell M, Clayden J. Interruption of a 3(10)-helix by a single Gly residue in a poly-Aib motif: a crystallographic study. Biopolymers. 95: 62-9. PMID 20725951 DOI: 10.1002/Bip.21535 |
0.556 |
|
| 2011 |
Clayton J, Clayden J. Attack on fluorinated 2-aryloxazolines by organolithiums: Dearomatisation, lithiation or substitution Tetrahedron Letters. 52: 2436-2439. DOI: 10.1016/J.Tetlet.2011.02.091 |
0.394 |
|
| 2011 |
Lefranc J, Tetlow DJ, Donnard M, Minassi A, Galvez E, Clayden J. ChemInform Abstract: Geometry-Selective Synthesis of (E) or (Z) N-Vinyl Ureas (N-Carbamoyl Enamines). Cheminform. 42: no-no. DOI: 10.1002/chin.201115096 |
0.804 |
|
| 2010 |
Tetlow DJ, Hennecke U, Raftery J, Waring MJ, Clarke DS, Clayden J. Sequential double α-arylation of N-allylureas by asymmetric deprotonation and N→C aryl migration. Organic Letters. 12: 5442-5. PMID 21062018 DOI: 10.1021/Ol102155H |
0.832 |
|
| 2010 |
Clayden J, Hennecke U, Vincent MA, Hillier IH, Helliwell M. The origin of the conformational preference of N,N'-diaryl-N,N'-dimethyl ureas. Physical Chemistry Chemical Physics : Pccp. 12: 15056-64. PMID 20953510 DOI: 10.1039/C0Cp00571A |
0.686 |
|
| 2010 |
Yuan B, Page A, Worrall CP, Escalettes F, Willies SC, McDouall JJ, Turner NJ, Clayden J. Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases. Angewandte Chemie (International Ed. in English). 49: 7010-3. PMID 20715245 DOI: 10.1002/Anie.201002580 |
0.342 |
|
| 2010 |
Solà J, Fletcher SP, Castellanos A, Clayden J. Nanometer-range communication of stereochemical information by reversible switching of molecular helicity. Angewandte Chemie (International Ed. in English). 49: 6836-9. PMID 20687056 DOI: 10.1002/Anie.201001130 |
0.646 |
|
| 2010 |
Clayden J. Organometallic reagents: deconstructing THF. Nature Chemistry. 2: 523-4. PMID 20571566 DOI: 10.1038/Nchem.712 |
0.335 |
|
| 2010 |
Brice H, Clayden J, Hamilton SD. Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones. Beilstein Journal of Organic Chemistry. 6: 22. PMID 20502604 DOI: 10.3762/Bjoc.6.22 |
0.401 |
|
| 2010 |
Clayden J, Donnard M, Lefranc J, Minassi A, Tetlow DJ. Tandem beta-alkylation-alpha-arylation of amines by carbolithiation and rearrangement of N-carbamoyl enamines (vinyl ureas). Journal of the American Chemical Society. 132: 6624-5. PMID 20411935 DOI: 10.1021/Ja1007992 |
0.814 |
|
| 2010 |
Fournier AM, Brown RA, Farnaby W, Miyatake-Ondozabal H, Clayden J. Synthesis of (-)-(S,S)-clemastine by invertive N --> C aryl migration in a lithiated carbamate. Organic Letters. 12: 2222-5. PMID 20405879 DOI: 10.1021/Ol100627C |
0.358 |
|
| 2010 |
Solà J, Helliwell M, Clayden J. N-versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib(8)GlyAib(8). Journal of the American Chemical Society. 132: 4548-9. PMID 20232805 DOI: 10.1021/Ja100662D |
0.623 |
|
| 2010 |
Clayden J, Donnard M, Lefranc J, Minassi A, Tetlow DJ. N-C Aryl Transfer via Umpolung Carbolithiation ofVinyl Ureas Synfacts. 2010: 929-929. DOI: 10.1055/S-0030-1257749 |
0.753 |
|
| 2010 |
Clayden J, Fletcher SP, Senior J, Worrall CP. Hindered diarylether and diarylsulfone bisphosphine ligands: Atropisomerism and palladium complexes Tetrahedron Asymmetry. 21: 1355-1360. DOI: 10.1016/J.Tetasy.2010.06.017 |
0.564 |
|
| 2010 |
Clayden J, Donnard M, Lefranc J, Minassi A, Teltow DJ. ChemInform Abstract: Tandem β-Alkylation-α-Arylation of Amines by Carbolithiation and Rearrangement of N-Carbamoyl Enamines (Vinyl Ureas). Cheminform. 41: no-no. DOI: 10.1002/chin.201038061 |
0.665 |
|
| 2010 |
Clayden J, Menet CJ, Mansfield DJ. ChemInform Abstract: Asymmetric Deprotonation and Dearomatizing Cyclization of N-Benzyl Benzamides Using Chiral Lithium Amides: Formal Synthesis of (-)-Kainic Acid. Cheminform. 33: no-no. DOI: 10.1002/CHIN.200223122 |
0.377 |
|
| 2010 |
Clayden J, Johnson P, Pink JH. ChemInform Abstract: Asymmetric Synthesis of Enantiomerically Enriched Atropisomeric Amides by Desymmetrization of N,N-Dialkylmesitamides. Cheminform. 32: no-no. DOI: 10.1002/CHIN.200130028 |
0.317 |
|
| 2010 |
Ahmed A, Clayden J, Rowley M. ChemInform Abstract: 1,3,4,5-Tetrahydroazepin-2-ones by Dearomatizing Anionic Cyclization of N-Allyl-1-naphthamides. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200012169 |
0.332 |
|
| 2010 |
CLAYDEN J, JULIA M. ChemInform Abstract: Carbenoids from Primary Alkyl Chlorides by Heteroatom-Assisted Metalation. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199533062 |
0.42 |
|
| 2010 |
CLAYDEN J, COONEY JJA, JULIA M. ChemInform Abstract: Nickel-Catalyzed Substitutions of Aryl tert-Butyl Sulfones with Organometallic Reagents: Synthesis of ortho-Substituted Unsymmetrical Biaryls. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199525103 |
0.563 |
|
| 2010 |
CLAYDEN J, JULIA M. ChemInform Abstract: Homoallylic Alcohols from Samarium Diiodide Mediated Coupling of Allylic Sulfones with Carbonyl Compounds. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199511090 |
0.448 |
|
| 2010 |
CLAYDEN J, JULIA M. ChemInform Abstract: Allylic Sulfones as Allyl Anion Equivalents: Homoallylic Alcohols from Metal Catalyzed Reactions of Sulfones with Aldehydes and Ketones. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199503081 |
0.487 |
|
| 2010 |
CLAYDEN J, JULIA M. ChemInform Abstract: ortho-Substituted Unsymmetrical Biaryls from Aryl tert-Butyl Sulfones. Cheminform. 25: no-no. DOI: 10.1002/CHIN.199410148 |
0.546 |
|
| 2009 |
Clayden J, Rowbottom SJ, Ebenezer WJ, Hutchings MG. Direct synthesis of sulfonated azacalixarenes in water. Organic & Biomolecular Chemistry. 7: 4871-80. PMID 19907777 DOI: 10.1039/B911631A |
0.328 |
|
| 2009 |
Clayden J, Moran WJ, Edwards PJ, LaPlante SR. The challenge of atropisomerism in drug discovery. Angewandte Chemie (International Ed. in English). 48: 6398-401. PMID 19637174 DOI: 10.1002/Anie.200901719 |
0.586 |
|
| 2009 |
Clayden J, Senior J, Helliwell M. Atropisomerism at C-S bonds: asymmetric synthesis of diaryl sulfones by dynamic resolution under thermodynamic control. Angewandte Chemie (International Ed. in English). 48: 6270-3. PMID 19610006 DOI: 10.1002/Anie.200901718 |
0.777 |
|
| 2009 |
Clayden J, Castellanos A, Solà J, Morris GA. Quantifying end-to-end conformational communication of chirality through an achiral peptide chain. Angewandte Chemie (International Ed. in English). 48: 5962-5. PMID 19569153 DOI: 10.1002/Anie.200901892 |
0.558 |
|
| 2009 |
Clayden J, Fletcher SP, Rowbottom SJ, Helliwell M. Conformational preferences of a polar biaryl: a phase- and enantiomeric purity-dependent molecular hinge. Organic Letters. 11: 2313-6. PMID 19435372 DOI: 10.1021/Ol9006635 |
0.541 |
|
| 2009 |
Brice H, Clayden J. Doubly dearomatising intramolecular coupling of a nucleophilic and an electrophilic heterocycle. Chemical Communications (Cambridge, England). 1964-6. PMID 19333458 DOI: 10.1039/B901558B |
0.415 |
|
| 2009 |
Clayden J. Transmission of stereochemical information over nanometre distances in chemical reactions. Chemical Society Reviews. 38: 817-29. PMID 19322473 DOI: 10.1039/B801639A |
0.345 |
|
| 2009 |
Clayden J, Fletcher SP, McDouall JJ, Rowbottom SJ. Controlling axial conformation in 2-arylpyridines and 1-arylisoquinolines: application to the asymmetric synthesis of QUINAP by dynamic thermodynamic resolution. Journal of the American Chemical Society. 131: 5331-43. PMID 19309078 DOI: 10.1021/Ja900722Q |
0.612 |
|
| 2009 |
Clayden J, Pickworth M, Jones LH. Relaying stereochemistry through aromatic ureas: 1,9 and 1,15 remote stereocontrol. Chemical Communications (Cambridge, England). 547-9. PMID 19283286 DOI: 10.1039/B817527F |
0.466 |
|
| 2009 |
Clayden J, Farnaby W, Grainger DM, Hennecke U, Mancinelli M, Tetlow DJ, Hillier IH, Vincent MA. N to C aryl migration in lithiated carbamates: alpha-arylation of benzylic alcohols. Journal of the American Chemical Society. 131: 3410-1. PMID 19275248 DOI: 10.1021/Ja808959E |
0.807 |
|
| 2009 |
Clayden J, Clayton J, Harvey RA, KarlubÍková O. A one-pot synthesis of 2-Aryl-4,5-anti-diphenyloxazolines Synlett. 2836-2838. DOI: 10.1055/S-0029-1217985 |
0.386 |
|
| 2009 |
Bach R, Clayden J, Hennecke U. α-arylation of cyclic amines by aryl transfer in lithiated ureas Synlett. 421-424. DOI: 10.1055/S-0028-1087543 |
0.709 |
|
| 2009 |
Clayden J, Rowbottom SJM, Hutchings MG, Ebenezer WJ. Formation of water-soluble sulfonated azacalix[4]arenes from cyanuric chloride Tetrahedron Letters. 50: 3923-3925. DOI: 10.1016/J.Tetlet.2009.04.068 |
0.368 |
|
| 2009 |
Clayden J, Turner H. Enantiomerically enriched atropisomeric N,N′-diaryl ureas by oxidative kinetic resolution of their 2-sulfanyl derivatives Tetrahedron Letters. 50: 3216-3219. DOI: 10.1016/J.Tetlet.2009.02.021 |
0.409 |
|
| 2009 |
Clayden J, Farnaby W, Grainger DM, Hennecke U, Mancinelli M, Tetlow DJ, Hillier IH, Vincent MA. ChemInform Abstract: N to C Aryl Migration in Lithiated Carbamates: α-Arylation of Benzylic Alcohols. Cheminform. 40. DOI: 10.1002/CHIN.200929036 |
0.751 |
|
| 2009 |
Clayden J, Moran W, Edwards P, LaPlante S. Atropisomerie als Herausforderung in der Medikamentenentwicklung Angewandte Chemie. 121: 6516-6520. DOI: 10.1002/Ange.200901719 |
0.563 |
|
| 2008 |
Bracegirdle A, Clayden J, Lai LW. Asymmetric synthesis of biaryl atropisomers by dynamic resolution on condensation of biaryl aldehydes with (-)-ephedrine or a proline-derived diamine. Beilstein Journal of Organic Chemistry. 4: 47. PMID 19190743 DOI: 10.3762/Bjoc.4.47 |
0.4 |
|
| 2008 |
Clayden J, Lemiègre L, Morris GA, Pickworth M, Snape TJ, Jones LH. Helix persistence and breakdown in oligoureas of metaphenylenediamine: apparent diastereotopicity as a spectroscopic marker of helix length in solution. Journal of the American Chemical Society. 130: 15193-202. PMID 18844355 DOI: 10.1021/Ja805758V |
0.709 |
|
| 2008 |
Clayden J, Lemiègre L, Pickworth M, Jones L. Conformation and stereodynamics of 2,2'-disubstituted N,N'-diaryl ureas. Organic & Biomolecular Chemistry. 6: 2908-13. PMID 18688483 DOI: 10.1039/B802673D |
0.736 |
|
| 2008 |
Clayden J, Hennecke U. Alpha-pyridylation of chiral amines via urea coupling, lithiation and rearrangement. Organic Letters. 10: 3567-70. PMID 18642922 DOI: 10.1021/Ol801332N |
0.677 |
|
| 2008 |
Arnott G, Brice H, Clayden J, Blaney E. Electrophile-induced dearomatizing spirocyclization of N-arylisonicotinamides: a route to spirocyclic piperidines. Organic Letters. 10: 3089-92. PMID 18553971 DOI: 10.1021/Ol801092S |
0.436 |
|
| 2008 |
Clayden J, Parris S, Cabedo N, Payne AH. Stereoselective dearomatizing addition of nucleophiles to uncomplexed benzene rings: a route to carbocyclic sugar analogues. Angewandte Chemie (International Ed. in English). 47: 5060-2. PMID 18512216 DOI: 10.1002/Anie.200801078 |
0.399 |
|
| 2008 |
Clayden J, Turner H, Helliwell M, Moir E. N,N'-diarylureas: a new family of atropisomers exhibiting highly diastereoselective reactivity. The Journal of Organic Chemistry. 73: 4415-23. PMID 18399672 DOI: 10.1021/Jo702706C |
0.435 |
|
| 2008 |
Clayden J, Worrall CP, Moran WJ, Helliwell M. Enantioselective synthesis of an atropisomeric diaryl ether. Angewandte Chemie (International Ed. in English). 47: 3234-7. PMID 18348136 DOI: 10.1002/Anie.200705660 |
0.681 |
|
| 2008 |
Clayden J, Vallverdú L, Clayton J, Helliwell M. Conformational switching between diastereoisomeric atropisomers of arenedicarboxamides induced by complexation with Lewis acids. Chemical Communications (Cambridge, England). 561-3. PMID 18209789 DOI: 10.1039/B716105K |
0.311 |
|
| 2008 |
Clayden J, Lemiègre L, Pickworth M. Synthesis of enantiomerically enriched isotopically-labelled anilines by (-)-sparteine directed lithiation Tetrahedron Asymmetry. 19: 2218-2221. DOI: 10.1016/J.Tetasy.2008.09.014 |
0.334 |
|
| 2008 |
Clayden J, Hennecke U. ChemInform Abstract: α-Pyridylation of Chiral Amines via Urea Coupling, Lithiation and Rearrangement. Cheminform. 39. DOI: 10.1002/chin.200851138 |
0.642 |
|
| 2007 |
Clayden J, Vallverdú L, Helliwell M. Transmitting information along oligo-para-phenylenes: 1,12-stereochemical control in a terphenyl tetracarboxamide. Chemical Communications (Cambridge, England). 2357-9. PMID 17844745 DOI: 10.1039/B701682D |
0.315 |
|
| 2007 |
Clayden J, Dufour J, Grainger DM, Helliwell M. Substituted diarylmethylamines by stereospecific intramolecular electrophilic arylation of lithiated ureas. Journal of the American Chemical Society. 129: 7488-9. PMID 17521189 DOI: 10.1021/Ja071523A |
0.483 |
|
| 2007 |
Betson MS, Bracegirdle A, Clayden J, Helliwell M, Lund A, Pickworth M, Snape TJ, Worrall CP. Achieving conformational control over C-C, C-N and C-O bonds in biaryls, N,N'-diarylureas and diaryl ethers: advantages of a relay axis. Chemical Communications (Cambridge, England). 754-6. PMID 17392973 DOI: 10.1039/B614618J |
0.398 |
|
| 2007 |
Clayden J, Moran WJ. Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions. Organic & Biomolecular Chemistry. 5: 1028-30. PMID 17377655 DOI: 10.1039/B700353F |
0.696 |
|
| 2007 |
Clayden J, Lemiègre L, Helliwell M. Synthesis and stacked conformations of symmetrical and unsymmetrical oligo-ureas of metaphenylenediamine. The Journal of Organic Chemistry. 72: 2302-8. PMID 17343415 DOI: 10.1021/Jo061989W |
0.733 |
|
| 2007 |
Clayden J, Dufour J, Grainger DM, Helliwell M. Lithium-Mediated Synthesis of Substituted Diarylmethylamines Synfacts. 2007: 962-962. DOI: 10.1055/S-2007-968846 |
0.386 |
|
| 2007 |
Clayden J, Hebditch KR, Read B, Helliwell M. Oxidative fragmentation of bicyclic hydroxy silanes and stannanes: a strategy for the stereoselective synthesis of kainoids Tetrahedron Letters. 48: 8550-8553. DOI: 10.1016/J.Tetlet.2007.09.150 |
0.396 |
|
| 2006 |
Arnott G, Clayden J, Hamilton SD. Azabicyclic amino acids by stereoselective dearomatizing cyclization of the enolates of N-nicotinoyl glycine derivatives. Organic Letters. 8: 5325-8. PMID 17078709 DOI: 10.1021/Ol062126S |
0.451 |
|
| 2006 |
Clayden J, Moran WJ. The twisted amide 2-quinuclidone: 60 years in the making. Angewandte Chemie (International Ed. in English). 45: 7118-20. PMID 17009382 DOI: 10.1002/Anie.200603016 |
0.595 |
|
| 2006 |
Betson MS, Clayden J, Worrall CP, Peace S. Three groups good, four groups bad? Atropisomerism in ortho-substituted diaryl ethers. Angewandte Chemie (International Ed. in English). 45: 5803-7. PMID 16874829 DOI: 10.1002/Anie.200601866 |
0.302 |
|
| 2006 |
Clayden J, Stimson CC, Keenan M. Contra-Friedel-Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation Chemical Communications. 1393-1394. PMID 16550277 DOI: 10.1039/B600181E |
0.378 |
|
| 2006 |
Clayden J, Foricher YJY, Helliwell M, Johnson P, Mitjans D, Vinader V. Conformational arm-wrestling: Battles for stereochemical control in benzamides bearing matched and mismatched chiral 2- and 6-substituents Organic and Biomolecular Chemistry. 4: 444-454. PMID 16446801 DOI: 10.1039/B514558A |
0.439 |
|
| 2006 |
Betson MS, Clayden J, Helliwell M, Johnson P, Lai LW, Pink JH, Stimson CC, Vassiliou N, Westlund N, Yasin SA, Youssef LH. Conformational preference in aromatic amides bearing chiral ortho substituents: Its origin and application to relayed stereocontrol Organic and Biomolecular Chemistry. 4: 424-443. PMID 16446800 DOI: 10.1039/B514557K |
0.389 |
|
| 2006 |
Clayden J, Stimson CC, Helliwell M, Keenan M. Addition of lithiated tertiary aromatic amides to epoxides and aziridines: Asymmetric synthesis of (S)-(+)-mellein Synlett. 873-876. DOI: 10.1055/S-2006-939043 |
0.428 |
|
| 2006 |
Betson MS, Clayden J. Synthesis of multiply ortho-substituted diaryl ethers via lithiation and oxidation of a dibenzosiloxane (phenoxasilin) Synlett. 745-746. DOI: 10.1055/S-2006-933111 |
0.344 |
|
| 2006 |
Clayden J, Vallverdú L, Helliwell M. Conformational communication between the Ar-CO and Ar-N axes in 2,2′-disubstituted benzanilides and their derivatives Organic and Biomolecular Chemistry. 4: 2106-2118. DOI: 10.1039/B602912D |
0.371 |
|
| 2006 |
Clayden J, Westlund N, Frampton CS, Helliwell M. Diastereoselective synthesis of atropisomers containing two non-biaryl stereogenic axes: Stereochemical relay through stereogenic centres in dihydrostilbene-2,2′-dicarboxamides Organic and Biomolecular Chemistry. 4: 455-461. DOI: 10.1039/B514561A |
0.449 |
|
| 2006 |
Clayden J, Dufour J. Lateral lithiation of N,N′-diaryl ureas Tetrahedron Letters. 47: 6945-6946. DOI: 10.1016/J.Tetlet.2006.07.134 |
0.46 |
|
| 2006 |
Clayden J, Moran WJ. Das gebogene Amid 2-Chinuclidon: Synthese nach 60 Jahren Angewandte Chemie. 118: 7276-7278. DOI: 10.1002/Ange.200603016 |
0.621 |
|
| 2005 |
Clayden J, Westlund N, Frampton CS, Helliwell M. Diastereoselective synthesis of atropisomers containing two non-biaryl stereogenic axes: stereochemical relay through stereogenic centres in dihydrostilbene-2,2'-dicarboxamides. Organic & Biomolecular Chemistry. 4: 455-61. PMID 16446802 DOI: 10.1039/b514561a |
0.335 |
|
| 2005 |
Adler T, Bonjoch J, Clayden J, Font-Bardía M, Pickworth M, Solans X, Solé D, Vallverdú L. Slow interconversion of enantiomeric conformers or atropisomers of anilide and urea derivatives of 2-substituted anilines Organic and Biomolecular Chemistry. 3: 3173-3183. PMID 16106298 DOI: 10.1039/B507202F |
0.437 |
|
| 2005 |
Clayden J, Hamilton SD, Mohammed RT. Cyclization of lithiated pyridine and quinoline carboxamides: Synthesis of partially saturated pyrrolopyridines and spirocyclic β-lactams Organic Letters. 7: 3673-3676. PMID 16092847 DOI: 10.1021/Ol051214U |
0.455 |
|
| 2005 |
Clayden J, Turner H, Pickworth M, Adler T. Ring-selective functionalization of N,N′-diarylureas by regioselective N-alkylation and directed ortho metalation Organic Letters. 7: 3147-3150. PMID 16018607 DOI: 10.1021/Ol0508025 |
0.433 |
|
| 2005 |
Clayden J, Knowles FE, Baldwin IR. The synthesis of (-)-isodomoic acid C Journal of the American Chemical Society. 127: 2412-2413. PMID 15724994 DOI: 10.1021/Ja042415G |
0.446 |
|
| 2005 |
Clayden J, Stimson CC, Keenan M. Asymmetric ortholithiation of amides by conformationally mediated chiral memory: An enantioselective route to naphtho- and benzofuranones Synlett. 1716-1720. DOI: 10.1055/S-2005-871554 |
0.417 |
|
| 2005 |
Betson MS, Clayden J, Helliwell M, Mitjans D. Kinetic and thermodynamic stereocontrol in the atroposelective formation of sulfoxides by oxidation of 2-sulfanyl-1-naphthamides Organic and Biomolecular Chemistry. 3: 3898-3904. DOI: 10.1039/B511452G |
0.338 |
|
| 2005 |
Clayden J, Turnbull R, Pinto I. Diastereoselective protonation of extended pyrrol-3-en-2-one enolates: An attempted 'de-epimerisation' Tetrahedron Asymmetry. 16: 2235-2241. DOI: 10.1016/J.Tetasy.2005.05.042 |
0.389 |
|
| 2005 |
Clayden J, Watson DW, Chambers M. Can relief of ring-strain in a cyclopropylmethyllithium drive the Brook rearrangement? Tetrahedron. 61: 3195-3203. DOI: 10.1016/J.Tet.2004.10.099 |
0.379 |
|
| 2005 |
Clayden J. Directed Metalation of Aromatic Compounds Cheminform. 36. DOI: 10.1002/9780470682531.Pat0306 |
0.319 |
|
| 2004 |
Clayden J, Turnbull R, Helliwell M, Pinto I. Dearomatising rearrangements of lithiated thiophenecarboxamides Chemical Communications. 10: 2430-2431. PMID 15514800 DOI: 10.1039/B409150G |
0.347 |
|
| 2004 |
Clayden J, Lund A, Vallverdú L, Helliwell M. Ultra-remote stereocontrol by conformational communication of information along a carbon chain. Nature. 431: 966-71. PMID 15496918 DOI: 10.1038/Nature02933 |
0.366 |
|
| 2004 |
Armstrong DR, Boss SR, Clayden J, Haigh R, Kirmani BA, Linton DJ, Schooler P, Wheatley AE. Controlling chemoselectivity in the lithiation of substituted aromatic tertiary amides. Angewandte Chemie (International Ed. in English). 43: 2135-8. PMID 15083465 DOI: 10.1002/Anie.200353324 |
0.388 |
|
| 2004 |
Clayden J, Turnbull R, Pinto I. Nucleophilic addition to electron-rich heteroaromatics: dearomatizing anionic cyclizations of pyrrolecarboxamides. Organic Letters. 6: 609-11. PMID 14961635 DOI: 10.1021/Ol0364071 |
0.441 |
|
| 2004 |
Clayden J, Kenworthy M. Cyclisations of Organolithiums onto Aromatic Rings Synthesis. 2004: 1721-1736. DOI: 10.1055/S-2004-829138 |
0.494 |
|
| 2004 |
Clayden J, Turnbull R, Pinto I. Nucleophilic Addition to Electron-Rich Heteroaromatics: Dearomatizing Anionic Cyclizations of Pyrrolecarboxamides Organic Letters. 6: 609-611. DOI: 10.1021/ol0364071 |
0.321 |
|
| 2004 |
Clayden J, Lai LW, Helliwell M. Dynamic resolution of atropisomeric amides using proline-derived imidazolines and ephedrine-derived oxazolidines Tetrahedron. 60: 4399-4412. DOI: 10.1016/J.Tet.2004.01.101 |
0.413 |
|
| 2004 |
Clayden J, Kubinski PM, Sammiceli F, Helliwell M, Diorazio L. Sulfoxides as ‘traceless’ resolving agents for the synthesis of atropisomers by dynamic or classical resolution Tetrahedron. 60: 4387-4397. DOI: 10.1016/J.Tet.2004.01.099 |
0.393 |
|
| 2003 |
Clayden J, Stimson CC, Keenan M, Wheatley AE. Fast racemisation and slow epimerisation of laterally lithiated amides: stereochemical evidence for the mechanism of inversion of amide-substituted benzyllithiums. Chemical Communications (Cambridge, England). 228-9. PMID 14737562 DOI: 10.1039/B310963A |
0.373 |
|
| 2003 |
Clayden J. Atropisomers and near-atropisomers: achieving stereoselectivity by exploiting the conformational preferences of aromatic amides. Chemical Communications (Cambridge, England). 127-35. PMID 14737515 DOI: 10.1039/B307976G |
0.397 |
|
| 2003 |
Clayden J, Watson DW, Helliwell M, Chambers M. Beta-lactams or gamma-lactams by 4-exo-trig or 5-endo-trig anionic cyclisation of lithiated acrylamide derivatives. Chemical Communications (Cambridge, England). 2582-3. PMID 14594291 DOI: 10.1039/B308029C |
0.306 |
|
| 2003 |
Clayden J, Knowles FE, Menet CJ. Stereospecific photochemical ring expansion of lithiated benzamides. Journal of the American Chemical Society. 125: 9278-9. PMID 12889941 DOI: 10.1021/Ja035827I |
0.437 |
|
| 2003 |
Clayden J, Kenworthy MN, Helliwell M. Dearomatizing cyclization of arylsulfonylalkoxymethyl lithiums: a route to the podophyllotoxin skeleton. Organic Letters. 5: 831-4. PMID 12633083 DOI: 10.1021/Ol0340585 |
0.432 |
|
| 2003 |
Clayden J, Purewal S, Helliwell M, Mantell SJ. Dearomatizing disrotatory electrocyclic ring closure of lithiated N-benzoyloxazolidines. Angewandte Chemie (International Ed. in English). 41: 1049-51. PMID 12491309 DOI: 10.1002/1521-3773(20020315)41:6<1049::Aid-Anie1049>3.0.Co;2-7 |
0.434 |
|
| 2003 |
Armstrong DR, Clayden J, Haigh R, Linton DJ, Schooler P, Wheatley AEH. Variations in the solid-state, solution and theoretical structures of a laterally deprotonated aromatic tertiary amide Chemical Communications. 9: 1694-1695. DOI: 10.1039/B302283H |
0.382 |
|
| 2003 |
Clayden J, Knowles FE, Menet CJ. Synthesis of α-methyl kainic acid by stereospecific lithiation–dearomatizing cyclization of a chiral benzamide Tetrahedron Letters. 44: 3397-3400. DOI: 10.1016/S0040-4039(03)00570-7 |
0.405 |
|
| 2003 |
Clayden J, Menet CJ. 2,3-Dihydroisoindolones by cyclisation and rearomatisation of lithiated benzamides Tetrahedron Letters. 44: 3059-3062. DOI: 10.1016/S0040-4039(03)00545-8 |
0.425 |
|
| 2003 |
Clayden J. Enantioselective Synthesis by Lithiation to Generate Planar or Axial Chirality Cheminform. 34. DOI: 10.1007/3-540-36117-0_8 |
0.36 |
|
| 2003 |
Clayden J, Menet CJ. 2,3-Dihydroisoindolones by Cyclization and Rearomatization of Lithiated Benzamides. Cheminform. 34. DOI: 10.1002/CHIN.200327104 |
0.312 |
|
| 2002 |
Clayden J, Foricher YJ, Lam HK. Carbolithiation of aromatic rings: cyclohexadienes from N-aroyl-2,2,6,6-tetramethylpiperidines. Chemical Communications (Cambridge, England). 2138-9. PMID 12357813 DOI: 10.1039/B206479K |
0.416 |
|
| 2002 |
Clayden J, Menet CJ, Mansfield DJ. Asymmetric deprotonation and dearomatising cyclisation of N-benzyl benzamides using chiral lithium amides: formal synthesis of (-)-kainic acid. Chemical Communications (Cambridge, England). 38-9. PMID 12120299 DOI: 10.1039/B109188C |
0.479 |
|
| 2002 |
Clayden J, Mitjans D, Youssef LH. Lithium-sulfoxide-lithium exchange for the asymmetric synthesis of atropisomers under thermodynamic control. Journal of the American Chemical Society. 124: 5266-7. PMID 11996557 DOI: 10.1021/Ja017702O |
0.405 |
|
| 2002 |
Bragg RA, Clayden J, Morris GA, Pink JH. Stereodynamics of bond rotation in tertiary aromatic amides. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 1279-89. PMID 11921211 DOI: 10.1002/1521-3765(20020315)8:6<1279::Aid-Chem1279>3.0.Co;2-7 |
0.427 |
|
| 2002 |
Clayden J, Kenworthy MN. Dearomatizing annelation of five-membered rings to naphthalenes by organolithium cyclization. Organic Letters. 4: 787-90. PMID 11869128 DOI: 10.1021/Ol0172626 |
0.405 |
|
| 2002 |
Clayden J, Lund A, Youssef LH. Conformational preference and remote (1,10) stereocontrol in biphenyl-2,2'-dicarboxamides. Organic Letters. 3: 4133-6. PMID 11784160 DOI: 10.1021/Ol0167457 |
0.47 |
|
| 2002 |
Clayden J, Helliwell M, Pink JH, Westlund N. Stereospecificity and stereoselectivity in electrophilic substitution reactions of non-alpha-heterosubstituted organolithiums and stannanes: a rotationally restricted amide as an internal stereochemical marker. Journal of the American Chemical Society. 123: 12449-57. PMID 11741407 DOI: 10.1021/Ja0112590 |
0.401 |
|
| 2002 |
Anstiss M, Clayden J, Grube A, Youssef LH. Lithiation and Stereoselective Transformations of 3-Aroyl-2,2,4,4-tetramethyloxazolidines (TMO Amides), a New Class of Acid-labile Atropisomeric Amides Synlett. 2002: 0290-0294. DOI: 10.1055/S-2002-19748 |
0.405 |
|
| 2002 |
Clayden J, Pink JH, Westlund N, Frampton CS. Atroposelectivity in the electrophilic substitution reactions of laterally lithiated and silylated tertiary amides Journal of the Chemical Society-Perkin Transactions 1. 901-917. DOI: 10.1039/B200358A |
0.42 |
|
| 2002 |
Clayden J, Yasin SA. Pathways for decomposition of THF by organolithiums: the role of HMPA New Journal of Chemistry. 26: 191-192. DOI: 10.1039/B109604D |
0.318 |
|
| 2002 |
Clayden J. Chapter 9 - Organolithiums in Synthesis Tetrahedron Organic Chemistry Series. 23. DOI: 10.1016/S1460-1567(02)80040-X |
0.327 |
|
| 2002 |
Clayden J. Chapter 7 – Regio- and Stereoselective Addition Reactions of Organolithiums Tetrahedron Organic Chemistry Series. 23: 273-335. DOI: 10.1016/S1460-1567(02)80038-1 |
0.324 |
|
| 2002 |
Clayden J. Chapter 6 - Stereoselective and Stereospecific Substitution Reactions of Organolithiums Tetrahedron Organic Chemistry Series. 23: 241-271. DOI: 10.1016/S1460-1567(02)80037-X |
0.354 |
|
| 2002 |
Clayden J. Chapter 5 - Stereoselective and Stereospecific Synthesis of Organolithiums Tetrahedron Organic Chemistry Series. 23: 169-240. DOI: 10.1016/S1460-1567(02)80036-8 |
0.362 |
|
| 2002 |
Clayden J. Chapter 4 - Regioselective Synthesis of Organolithiums by C–X Reduction Tetrahedron Organic Chemistry Series. 23: 149-168. DOI: 10.1016/S1460-1567(02)80035-6 |
0.353 |
|
| 2002 |
Clayden J. Chapter 2 - Regioselective Synthesis of Organolithiums by Deprotonation Tetrahedron Organic Chemistry Series. 23. DOI: 10.1016/S1460-1567(02)80033-2 |
0.367 |
|
| 2002 |
Bragg RA, Clayden J, Menet CJ. 'meso-Selective' functionalisation of N-benzyl-α-methylbenzylamine derivatives by α-lithiation and alkylation Tetrahedron Letters. 43: 1955-1959. DOI: 10.1016/S0040-4039(02)00154-5 |
0.405 |
|
| 2002 |
Clayden J, Menet CJ, Tchabanenko K. Synthesis of (−)-kainic acid using chiral lithium amides in an asymmetric dearomatizing cyclization Tetrahedron. 58: 4727-4733. DOI: 10.1016/S0040-4020(02)00379-4 |
0.48 |
|
| 2002 |
Clayden J, Foricher Y, Lam H. Intermolecular Dearomatising Addition of Organolithium Compounds to N-Benzoylamides of 2,2,6,6-Tetramethylpiperidine European Journal of Organic Chemistry. 2002: 3558-3565. DOI: 10.1002/1099-0690(200211)2002:21<3558::Aid-Ejoc3558>3.0.Co;2-5 |
0.466 |
|
| 2001 |
Clayden J, Davies RP, Hendy MA, Snaith R, Wheatley AE. The First Crystallographic Evidence for the Structures of ortho-Lithiated Aromatic Tertiary Amides This work was supported by the UK EPSRC (M.A.H.), and St. Catharine's (R.P.D.) and Gonville & Caius (A.E.H.W.) Colleges, Cambridge. Angewandte Chemie (International Ed. in English). 40: 1238-1240. PMID 11301436 DOI: 10.1002/1521-3773(20010401)40:7<1238::Aid-Anie1238>3.0.Co;2-G |
0.387 |
|
| 2001 |
Bond AD, Clayden J, Wheatley AEH. N,N-Diisopropyl-1-naphthamide Acta Crystallographica Section E Structure Reports Online. 57: o292-o294. DOI: 10.1107/S1600536801003580 |
0.361 |
|
| 2001 |
Clayden J, Johnson P, Pink JH. Asymmetric synthesis of enantiomerically enriched atropisomeric amides by desymmetrisation of N,N-dialkylmesitamides Journal of the Chemical Society-Perkin Transactions 1. 371-375. DOI: 10.1039/B008678I |
0.44 |
|
| 2001 |
Clayden J, Lai LW, Helliwell M. Using amide conformation to ‘project’ the stereochemistry of an (−)-ephedrine-derived oxazolidine: a pair of pseudoenantiomeric chiral amido-phosphine ligands Tetrahedron: Asymmetry. 12: 695-698. DOI: 10.1016/S0957-4166(01)00110-0 |
0.386 |
|
| 2001 |
Bragg RA, Clayden J, Bladon M, Ichihara O. Dearomatising cyclisation of lithiated 1-naphthamides with a phenylglycinol-derived chiral auxiliary: Asymmetric synthesis of an arylkainoid and a kainoid-like pyroglutamate Tetrahedron Letters. 42: 3411-3414. DOI: 10.1016/S0040-4039(01)00502-0 |
0.449 |
|
| 2001 |
Ahmed A, Bragg RA, Clayden J, Tchabanenko K. Synthesis of a potent (±)-4-(2-hydroxyphenyl) analogue of the acromelic acids by dearomatising cyclisation of a lithiated N-p-methoxybenzyl-4-methoxy-1-naphthamide Tetrahedron Letters. 42: 3407-3410. DOI: 10.1016/S0040-4039(01)00501-9 |
0.449 |
|
| 2001 |
Clayden J, Lai LW. (−)-Ephedrine as an auxiliary for the asymmetric synthesis of atropisomeric amides by dynamic resolution under thermodynamic control Tetrahedron Letters. 42: 3163-3166. DOI: 10.1016/S0040-4039(01)00416-6 |
0.442 |
|
| 2001 |
Clayden J, Menet CJ, Mansfield DJ. ChemInform Abstract: Dearomatizing Anionic Cyclization of Substituted N-Cumyl-N-benzylbenzamides on Treatment with LDA: Synthesis of Partially Saturated Substituted Isoindolones. Cheminform. 32: no-no. DOI: 10.1002/CHIN.200116130 |
0.338 |
|
| 2001 |
Clayden J, Davies RP, Hendy MA, Snaith R, Wheatley AEH. Kristallographische Befunde zur Struktur ortholithiierter aromatischer tertiärer Amide Angewandte Chemie. 113: 1282-1285. DOI: 10.1002/1521-3757(20010401)113:7<1282::Aid-Ange1282>3.0.Co;2-I |
0.397 |
|
| 2000 |
Clayden J, Menet CJ, Mansfield DJ. Dearomatizing Anionic Cyclization of Substituted N-Cumyl-N-benzyl- benzamides on Treatment with LDA: Synthesis of Partially Saturated Substituted Isoindolones Organic Letters. 2: 4229-4232. PMID 11150206 DOI: 10.1021/Ol006786N |
0.433 |
|
| 2000 |
Clayden J, Johnson P, Pink JH, Helliwell M. Atropisomeric Amides as Chiral Ligands: Using (-)-Sparteine-Directed Enantioselective Silylation to Control the Conformation of a Stereogenic Axis Journal of Organic Chemistry. 65: 7033-7040. PMID 11031025 DOI: 10.1021/Jo0007074 |
0.459 |
|
| 2000 |
Bragg RA, Clayden J. Using symmetry to monitor geared bond rotation in aromatic amides by dynamic NMR Organic Letters. 2: 3351-3354. PMID 11029208 DOI: 10.1021/Ol0064462 |
0.364 |
|
| 2000 |
Clayden J, Helliwell M, McCarthy C, Westlund N. Atropisomeric benzamides and naphthamides as chiral auxiliaries Journal of the Chemical Society-Perkin Transactions 1. 3232-3249. DOI: 10.1039/B004682P |
0.434 |
|
| 2000 |
Clayden J, Westlund N, Frampton CS. Atropisomeric diastereoisomers from nucleophilic attack on 8-acyl-1-naphthamides Journal of the Chemical Society-Perkin Transactions 1. 1379-1385. DOI: 10.1039/B000670J |
0.427 |
|
| 2000 |
Clayden J, McCarthy C, Westlund N, Frampton CS. Atroposelective attack of nucleophiles on 2-formyl-1-naphthamides and their derivatives: chelation and non-chelation control Journal of the Chemical Society-Perkin Transactions 1. 1363-1378. DOI: 10.1039/B000669F |
0.401 |
|
| 2000 |
Clayden J, Tchabanenko K. Synthesis of (±)-kainic acid by dearomatising cyclisation of a lithiated N-benzyl p-anisamide Chemical Communications. 317-318. DOI: 10.1039/A909325G |
0.359 |
|
| 2000 |
Clayden J, Kenworthy MN, Youssef LH, Helliwell M. Axial chirality in xanthene-4,5-dicarboxamides: 1,9-stereocontrol mediated by remote interactions between conformationally constrained amide groups Tetrahedron Letters. 41: 5171-5175. DOI: 10.1016/S0040-4039(00)00833-9 |
0.389 |
|
| 2000 |
Clayden J, McCarthy C, Cumming JG. Dynamically resolved peri-substituted 2-formyl naphthamides: a new class of atropisomeric chiral auxiliary Tetrahedron Letters. 41: 3279-3283. DOI: 10.1016/S0040-4039(00)00397-X |
0.448 |
|
| 1999 |
Ahmed A, Clayden J, Rowley M. 1,3,4,5-Tetrahydroazepin-2-ones by Dearomatising Anionic Cyclisation of N-Allyl-1-Naphthamides Synlett. 1999: 1954-1956. DOI: 10.1055/S-1999-2977 |
0.408 |
|
| 1999 |
Clayden J, McCarthy C, Helliwell M. Bonded peri-interactions govern the rate of racemisation of atropisomeric 8-substituted 1-naphthamides† Chemical Communications. 2059-2060. DOI: 10.1039/A906398F |
0.369 |
|
| 1999 |
Ahmed A, Clayden J, Yasin SA. Dearomatising cyclisations of lithiated N-benzylbenzamides Chemical Communications. 231-232. DOI: 10.1039/A808218I |
0.435 |
|
| 1999 |
Bragg RA, Clayden J. Diastereoselective ortholithiation and conformational control in stereospecific dearomatising anionic cyclisations Tetrahedron Letters. 40: 8327-8331. DOI: 10.1016/S0040-4039(99)01766-9 |
0.454 |
|
| 1999 |
Bragg RA, Clayden J. Stereospecific formation of tetrasubstituted centres from trisubstituted centres during dearomatising anionic cyclisations Tetrahedron Letters. 40: 8323-8326. DOI: 10.1016/S0040-4039(99)01765-7 |
0.468 |
|
| 1999 |
Clayden J, Westlund N, Wilson FX. Diastereoisomeric atropisomers of peri-substituted naphthamides: synthesis, stereoselectivity and stability Tetrahedron Letters. 40: 7883-7887. DOI: 10.1016/S0040-4039(99)01644-5 |
0.371 |
|
| 1999 |
Clayden J, Westlund N, Wilson FX. Synthesis of atropisomeric diamides with remotely related stereogenic axes by stereoselective additions to imines Tetrahedron Letters. 40: 3331-3334. DOI: 10.1016/S0040-4039(99)00520-1 |
0.434 |
|
| 1999 |
Clayden J, Westlund N, Wilson FX. Synthesis of atropisomeric 2-(1-aminoalkyl)-1-naphthamides by stereoselective addition of organolithiums to a 2-imino-1-naphthamide Tetrahedron Letters. 40: 3329-3330. DOI: 10.1016/S0040-4039(99)00519-5 |
0.427 |
|
| 1999 |
Clayden J, Frampton CS, McCarthy C, Westlund N. Perilithiation and the synthesis of 8-substituted-1-naphthamides Tetrahedron. 55: 14161-14184. DOI: 10.1016/S0040-4020(99)00881-9 |
0.373 |
|
| 1998 |
Clayden J. Stereocontrol with Rotationally Restricted Amides Synlett. 1998: 810-816. DOI: 10.1055/S-1998-1784 |
0.369 |
|
| 1998 |
Clayden J, Warren S. Control of stereochemistry with phosphine oxides: asymmetric synthesis of 4-alkenyloxazolidin-2-ones with 1,4-related stereogenic centres across a double bond Journal of the Chemical Society-Perkin Transactions 1. 2923-2932. DOI: 10.1039/A802577K |
0.573 |
|
| 1998 |
Ahmed A, Clayden J, Rowley M. Anionic cyclisations of an N-benzyl naphthamide: a route to benzo[e]isoindolones Chemical Communications. 297-298. DOI: 10.1039/A707683E |
0.416 |
|
| 1998 |
Clayden J, McCarthy C, Cumming JG. (S)-2-(Dibenzylamino)-3-phenylpropanal as a chiral auxiliary: a new strategy for the asymmetric synthesis of 2-substituted alcohols Tetrahedron: Asymmetry. 9: 1427-1440. DOI: 10.1016/S0957-4166(98)00120-7 |
0.393 |
|
| 1998 |
Clayden J, Pink JH, Westlund N, Wilson FX. Controlling the regioselectivity of lithiation using kinetic isotope effects: Deuterium as a protecting group for carbon Tetrahedron Letters. 39: 8377-8380. DOI: 10.1016/S0040-4039(98)01930-3 |
0.369 |
|
| 1998 |
Ahmed A, Clayden J, Rowley M. Anion translocation in organolithiums: A mechanism for the lithiation and cyclisation of tertiary naphthamides Tetrahedron Letters. 39: 6103-6106. DOI: 10.1016/S0040-4039(98)01291-X |
0.322 |
|
| 1998 |
Clayden J, Pink JH, Yasin SA. Conformationally Interlocked Amides: Remote Asymmetric Induction by Mechanical Transfer of Stereochemical Information Tetrahedron Letters. 39: 105-108. DOI: 10.1016/S0040-4039(97)10443-9 |
0.411 |
|
| 1998 |
Ahmed A, Bragg RA, Clayden J, Lai LW, McCarthy C, Pink JH, Westlund N, Yasin SA. Barriers to rotation about the chiral axis of tertiary aromatic amides Tetrahedron. 54: 13277-13294. DOI: 10.1016/S0040-4020(98)00814-X |
0.37 |
|
| 1998 |
Clayden J, Pink JH. Concerted Rotation in a Tertiary Aromatic Amide: Towards a Simple Molecular Gear Angewandte Chemie International Edition. 37: 1937-1939. DOI: 10.1002/(Sici)1521-3773(19980803)37:13/14<1937::Aid-Anie1937>3.0.Co;2-4 |
0.311 |
|
| 1997 |
Bowles P, Clayden J, Helliwell M, McCarthy C, Tomkinson M, Westlund N. Atroposelectivity In The Reactions Of Ortholithiated Aromatic Tertiary Amides With Aldehydes Journal of the Chemical Society-Perkin Transactions 1. 2607-2616. DOI: 10.1039/A701671I |
0.44 |
|
| 1997 |
Clayden J, Darbyshire M, Pink JH, Westlund N, Wilson FX. Remote stereocontrol using rotationally restricted amides: (1,5)-asymmetric induction Tetrahedron Letters. 38: 8587-8590. DOI: 10.1016/S0040-4039(97)10289-1 |
0.398 |
|
| 1997 |
Clayden J, Nelson A, Warren S. Diastereoselective reactions of optically active γ-substituted vinyl phosphine oxides Tetrahedron Letters. 38: 3471-3474. DOI: 10.1016/S0040-4039(97)00658-8 |
0.516 |
|
| 1997 |
Clayden* J, Pink JH. Configurational Stability and Stereospecificity in the Reactions of Amide-Stabilised Organolithiums: A Non-Stereospecific Tin-Lithium Exchange Tetrahedron Letters. 38: 2565-2568. DOI: 10.1016/S0040-4039(97)00402-4 |
0.353 |
|
| 1997 |
Clayden J, Pink JH. Atroposelectivity in the Reactions of Laterally Lithiated Tertiary Amides Tetrahedron Letters. 38: 2561-2564. DOI: 10.1016/S0040-4039(97)00401-2 |
0.402 |
|
| 1996 |
Clayden J, Westlund N, Wilson FX. Asymmetric induction using atropisomers: Diastereoselective additions to 2-acyl-1-naphthamides Tetrahedron Letters. 37: 5577-5580. DOI: 10.1016/0040-4039(96)01129-X |
0.443 |
|
| 1996 |
Clayden J, Warren S. Stereocontrol in Organic Synthesis Using the Diphenylphosphoryl Group Angewandte Chemie International Edition in English. 35: 241-270. DOI: 10.1002/Anie.199602411 |
0.525 |
|
| 1996 |
Clayden J, Warren S. Stereokontrolle in der organischen Synthese durch Verwendung der Diphenylphosphorylgruppe Angewandte Chemie. 108: 261-291. DOI: 10.1002/Ange.19961080304 |
0.498 |
|
| 1995 |
Clayden J, Julia M. Carbenoids from Primary Alkyl Chlorides by Heteroatom-Assisted Metallation Synlett. 1995: 103-104. DOI: 10.1055/S-1995-4849 |
0.475 |
|
| 1995 |
Clayden J, McElroy AB, Warren S. Control over absolute (R,S), relative (syn,anti) and geometrical (E,Z) stereochemistry in the synthesis of allylically substituted alkenes from diphenylphosphinoyl epoxy alcohols Journal of the Chemical Society, Perkin Transactions 1. 1913-1934. DOI: 10.1039/P19950001913 |
0.531 |
|
| 1995 |
Clayden J, Cooney JJA, Julia M. Nickel-catalysed substitutions of aryl tert-butyl sulfones with organometallic reagents: synthesis of ortho-substituted unsymmetrical biaryls Journal of the Chemical Society-Perkin Transactions 1. 7-14. DOI: 10.1039/P19950000007 |
0.592 |
|
| 1995 |
Bowles P, Clayden J, Tomkinson M. Diastereoisomeric atropisomers from the addition of lithiated N,N-dialkyl-l-naphthamides to aldehydes Tetrahedron Letters. 36: 9219-9222. DOI: 10.1016/0040-4039(95)01945-E |
0.409 |
|
| 1994 |
Clayden J, Warren S. Asymmetric epoxidation and kinetic resolution of allylic phosphine oxides Journal of the Chemical Society-Perkin Transactions 1. 2811-2823. DOI: 10.1039/P19940002811 |
0.544 |
|
| 1994 |
Clayden J, Collington EW, Egert E, McElroy AB, Warren S. Diastereoselective epoxidation of allylic phosphine oxides Journal of the Chemical Society-Perkin Transactions 1. 2801-2810. DOI: 10.1039/P19940002801 |
0.481 |
|
| 1994 |
Clayden J, Warren S. Additions of lithiated β-hydroxy alkyldiphenylphosphine oxides to aldehydes, and palladium(II)-catalysed allylic transpositions of bis-acetoxy alkyldiphenylphosphine oxides: synthesis of O-protected (E,E)- and (E,Z)hepta-2,4-dien-1-ol and of alkyldiphenylphosphine oxides bearing remotely related chiral centres Journal of the Chemical Society-Perkin Transactions 1. 1529-1539. DOI: 10.1039/P19940001529 |
0.506 |
|
| 1994 |
Clayden J, Julia M. Homoallylic alcohols from samarium diiodide-mediated coupling of allylic sulfones with carbonyl compounds Journal of the Chemical Society, Chemical Communications. 2261-2262. DOI: 10.1039/C39940002261 |
0.513 |
|
| 1994 |
Clayden J, Julia M. Allylic sulfones as allyl anion equivalents: homoallylic alcohols from metal catalysed reactions of sulfones with aldehydes and ketones Journal of the Chemical Society, Chemical Communications. 1905-1906. DOI: 10.1039/C39940001905 |
0.545 |
|
| 1993 |
Clayden J, Collington EW, Elliott J, Martin SJ, McElroy AB, Warren S, Waterson D. Stereochemical control (E/Z and syn/anti) by the diphenylphosphinoyl group in the synthesis of allylic alcohols by allylic rearrangement and by 1,4-diastereoselective reduction of enones Journal of the Chemical Society-Perkin Transactions 1. 1849-1859. DOI: 10.1039/P19930001849 |
0.566 |
|
| 1993 |
Clayden J, Julia M. ortho-Substituted unsymmetrical biaryls from aryl tert-butyl sulfones Journal of the Chemical Society, Chemical Communications. 1682-1683. DOI: 10.1039/C39930001682 |
0.6 |
|
| 1993 |
Clayden J, Collington EW, Warren S. Stereocontrolled synthesis of R or S E or Z unsaturated α—amino acids by enantio- and diastereoselective epoxidation of δ-hydroxy allylic phosphine oxides Tetrahedron Letters. 34: 1327-1330. DOI: 10.1016/S0040-4039(00)91787-8 |
0.541 |
|
| 1993 |
Clayden J, Collington EW, Lamount R, Warren S. Alkenyl oxazolidinones by stereoselective epoxidation of δ-hydroxy allylic phosphine oxides: Synthesis of any isomer (RR, RS, SR or SS; E or Z) bearing 1,4-related chiral centres across a double bond Tetrahedron Letters. 34: 2203-2206. DOI: 10.1016/S0040-4039(00)60383-0 |
0.581 |
|
| 1992 |
Clayden J, Collington EW, Warren S. Asymmetric epoxidations and kinetic resolutions of δ-hydroxy allylic phosphine oxides Tetrahedron Letters. 33: 7043-7046. DOI: 10.1016/S0040-4039(00)60928-0 |
0.567 |
|
| 1992 |
Clayden J, Collington EW, Warren S. The synthesis of δ-hydroxy allylic phosphine oxides by palladium(II)-catalysed allylic transposition Tetrahedron Letters. 33: 7039-7042. DOI: 10.1016/S0040-4039(00)60927-9 |
0.563 |
|
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